Hub : Genes

CYB5B

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.1360	0.0550	0.0008	0.050	NA	0.061	NA	0.080	1.2e-04	NA	2.2e-05	NA	1.3e-06
2	GTEx	Nerve Tibial	0.1535	0.0602	0.0033	0.045	NA	0.070	NA	0.079	4.0e-04	NA	1.1e-05	NA	3.0e-06
3	GTEx	Skin Sun Exposed Lower leg	0.1230	0.0540	0.0062	-0.001	NA	0.022	NA	0.012	4.5e-01	NA	5.4e-03	NA	3.4e-02
4	METSIM	Adipose	0.0334	0.0169	0.0072	0.025	0.016	0.013	0.017	0.013	1.1e-04	1.5e-03	3.5e-03	1.2e-03	4.1e-03
5	YFS	Blood	0.1804	0.0388	0.0000	0.016	0.078	0.089	0.081	0.084	4.7e-06	2.2e-24	1.8e-27	4.0e-25	5.4e-26
6	TCGA	Thyroid Carcinoma	0.0410	0.0200	0.0017	0.019	0.023	0.038	NA	0.033	5.7e-03	2.2e-03	1.3e-04	NA	3.4e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	3.7	5.8	9.7	-3.0	-3.1	-1.6	1.6	1.3	-3.0
Bipolar Disorder or Schizophrenia	1.6	3.8	10.4	-1.9	-1.8	-1.0	3.2	1.0	-1.9
Depressed Affect (Nagel 2018)	1.9	4.1	12.7	-1.0	0.1	-1.5	-2.9	-3.6	-0.4
Depression (Nagel 2018)	1.4	2.1	8.4	-0.7	0.9	-1.1	-0.9	-2.9	0.8
Intelligence (Savage-Jansen 2018)	0.4	1.4	3.3	-0.6	-0.7	1.6	-1.8	1.0	-0.7
Neuroticism (Nagel 2018)	1.7	4.0	9.7	-0.7	1.0	-2.4	-2.6	-3.1	0.3
Schizophrenia (2018)	0.6	1.3	7.5	0.0	0.1	0.1	2.7	-0.3	0.0
Schizophrenia vs Biploar Disorder	1.6	2.2	3.7	1.5	1.9	1.4	0.3	-1.3	1.8
Worry (Nagel 2018)	1.5	3.1	12.2	-1.0	0.6	-3.5	-1.1	-1.9	-0.4
Alzheimer’s Disease (in mother)	0.0	0.1	0.2	0.1	-0.2	0.3	-0.4	0.2	0.0
Alzheimer’s Disease (in father)	2.0	2.2	4.4	-2.1	-1.8	-1.8	0.1	0.1	-1.5
Alzheimer’s Disease (including proxy)	0.5	0.7	1.4	-1.1	-1.2	-1.0	-0.5	-0.1	-0.9
Crohns Disease (2017)	1.0	2.2	4.6	1.0	1.5	1.2	-0.8	2.2	1.9
Irritable Bowel Disease (IBD)	1.5	3.5	10.0	0.9	0.4	2.3	1.5	3.2	1.5
Ulcerative Colitis (UC)	2.0	3.8	8.9	0.4	-0.8	2.6	2.5	3.0	0.2
Major Depression (MDD)	0.8	0.9	1.9	1.0	1.1	0.6	-0.8	-0.4	1.4
Reaction Time	0.2	0.3	1.6	-0.1	-0.3	-1.3	0.3	-0.1	0.2
Verbal and Numeric Reasoning (VNR)	0.6	1.5	4.9	0.1	0.2	2.2	-1.8	0.8	0.4
Breast Cancer	0.3	0.7	3.0	-0.4	-0.7	-1.7	0.5	-0.1	-0.4
Ovarian Cancer	0.7	0.9	1.9	-0.4	-1.4	-0.5	-1.1	0.5	-1.4
Prostate Cancer	0.1	0.2	0.6	0.1	-0.4	0.8	-0.3	0.7	-0.0
Age at First Birth	0.3	0.5	1.2	0.9	0.7	1.1	-0.2	-0.1	0.5
Bipolar Disorder (2011)	1.8	1.7	2.6	-1.6	-1.5	-1.3	1.0	1.1	-1.3
Body Mass Index (BMI) (2010)	0.2	0.3	1.1	-0.4	-0.4	0.2	-1.1	0.3	-0.2
Coronary Artery Disease (CAD)	0.6	0.7	1.8	-0.8	-0.4	-1.0	0.1	1.3	-0.7
Crohns Disease (2012)	0.9	1.4	4.8	-0.0	0.4	1.0	-1.3	2.2	0.8
Mean Putamen Volume	0.2	0.3	0.9	0.2	-0.3	1.0	-0.3	0.5	0.4
Fasting Glucose	0.4	0.4	1.7	0.4	0.4	1.3	0.1	-0.1	0.7
HbA1C	0.6	0.7	1.9	0.2	-0.6	1.0	-0.7	1.4	-0.2
HDL Cholesterol	0.5	0.8	3.7	-0.7	0.6	-1.9	0.5	-0.1	0.2
LDL Cholesterol	0.2	0.3	1.5	-0.1	-1.2	-0.1	-0.3	0.6	-0.3
Lupus	0.6	0.9	3.5	0.9	1.9	-0.0	0.3	0.1	0.9
Neuroticism (2016)	1.9	2.8	7.1	1.2	1.6	-0.3	-1.5	-2.7	1.8
Primary Biliary Cirrhosis	0.4	0.6	1.5	-0.5	-1.1	-0.1	1.2	-0.1	-0.8
Rheumatoid Arthritis	0.3	0.4	0.9	-0.8	0.1	-1.0	0.9	-0.1	-0.3
Schizophrenia (2014)	0.5	1.0	4.9	-0.8	-0.1	-0.5	2.2	-0.2	-0.6
Triglycerides	0.6	1.0	1.7	-0.7	-0.8	1.1	-1.3	-1.0	-0.9
Type 2 Diabetes (T2D) (2012)	1.2	1.4	4.2	1.3	-0.2	1.2	-0.2	2.1	0.9
Ulcerative Colitis	1.9	2.7	11.1	-1.1	-0.7	0.8	1.6	3.3	-0.4
Blood Eosinophil Count	0.6	4.5	17.3	0.7	-1.2	4.2	-2.3	-1.4	-0.9
Blood Platelet Count	0.0	0.2	0.5	-0.1	-0.7	0.0	-0.4	0.5	-0.4
Blood Red Count	0.4	4.2	11.6	1.3	-0.2	2.9	-1.8	3.4	0.1
Blood White Count	0.4	3.3	10.0	0.1	-1.5	3.2	0.0	2.6	-0.7
Heel T-Score	1.8	14.2	25.6	-4.8	-4.2	-5.1	0.7	1.3	-4.0
BMI	1.2	7.1	28.8	-0.1	-1.9	5.4	-1.9	2.6	0.1
Height	0.9	16.5	71.4	0.3	4.4	-8.4	-1.8	-1.5	1.6
Waist Hip Ratio (WHR)	1.1	4.9	8.3	2.7	2.9	1.4	-1.9	-0.9	2.7
Systolic Blood Pressure	0.2	1.0	2.8	-0.5	-1.7	0.2	-1.0	0.9	-1.0
Smoking Status	1.1	2.7	6.7	1.1	0.7	1.8	-1.0	-2.6	1.9
Allergy or Eczema	0.3	0.7	1.6	-0.8	-1.3	-1.1	0.3	0.6	-0.6
Cardiovascular Disease	0.6	2.0	4.8	1.2	0.5	2.2	-2.1	0.4	0.8
Hypothyroidism (self reported)	1.4	3.2	11.2	-1.5	-0.9	-0.2	-3.4	-1.6	-1.5
Respiratory disease	0.7	1.5	3.5	-1.2	-1.6	-0.1	0.5	-1.9	-1.0
Type 2 Diabetes (T2D) (2018)	2.0	3.8	16.3	2.0	0.5	4.0	-0.3	0.8	1.3
Lung FEV1/FVC ratio	0.5	2.7	4.8	1.8	0.8	1.7	1.3	2.2	1.6
Lung FVC	0.8	4.0	13.6	0.6	1.5	-3.7	1.3	-0.9	2.2
Neuroticism	1.5	3.6	10.5	0.2	1.5	-1.7	-2.3	-3.2	0.7
Chronotype (morning person)	0.8	1.9	3.5	1.2	1.6	-1.0	1.9	-0.1	1.6
Hair Pigment	0.1	2.3	4.4	2.0	1.7	0.8	1.1	0.7	2.1
Tanning	0.1	0.8	3.1	-0.5	-0.9	-0.6	0.2	-1.8	-0.5
Hand grip strength (left)	1.4	3.6	17.1	-1.4	-0.6	-4.1	1.3	0.2	-0.8
Number of treatments/medications taken	1.7	3.0	8.1	0.8	1.3	2.2	-2.8	-1.5	0.8
Average weekly spirits intake	1.6	2.0	4.8	-0.6	-1.9	1.4	0.4	2.2	-1.0
Sensitivity / hurt feelings	1.5	2.5	5.9	0.9	2.4	-1.1	-1.4	-1.4	1.9
Frequency of depressed mood in last 2 weeks	1.7	2.3	8.2	0.0	1.7	-0.5	-0.7	-2.9	1.5
Hearing difficulty/problems: Yes	0.5	0.7	1.7	0.5	0.0	1.2	1.3	0.7	0.6
Relative age of first facial hair	1.2	2.6	7.1	-1.5	-2.7	-1.4	0.3	-0.2	-2.0
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	2.2	0.6	1.4	1.1	-0.3	-1.5	1.1
Ever used hormone-replacement therapy (HRT)	0.4	0.6	1.8	-0.1	-0.7	-1.3	-0.7	-0.8	0.2
Ever had hysterectomy (womb removed)	0.6	0.7	2.0	-0.9	-0.4	0.2	-1.4	-0.9	-0.5
Systolic blood pressure, automated reading	0.5	1.4	3.8	-0.1	-1.9	0.9	-0.4	1.9	-0.7
Eye problems/disorders: Diabetes related eye disease	1.7	1.8	6.0	1.1	-0.2	2.5	0.3	1.9	0.5
Angina	1.5	2.0	5.3	0.3	1.4	1.5	-2.3	-1.1	1.1
Medication for hormone replacement therapy	1.7	2.0	7.1	-0.1	0.2	-1.6	-1.4	-2.7	-0.0
Vitamin and mineral supplements	0.7	0.9	1.7	-1.0	-1.3	-0.0	-0.1	1.1	-1.2
Supplements: Zinc	0.6	0.7	1.7	-0.8	-0.1	-1.3	-1.1	-0.5	-0.1
Medication: Co-codamol	2.4	2.8	5.0	1.6	2.2	1.4	-1.6	-1.1	1.9
Medication: Metformin	2.3	3.2	9.2	1.7	1.4	3.0	-1.7	0.6	1.5
Diabetes (father)	1.5	1.9	3.8	1.2	2.0	1.7	0.4	-1.2	1.1
Diabetes (mother)	0.3	0.4	1.3	0.0	0.6	1.1	-0.7	-0.4	0.5
Severe depression (siblings)	0.3	0.3	0.6	-0.8	-0.5	-0.8	0.4	-0.3	-0.6
Pack years adult smoking proportion	0.6	1.0	4.6	0.7	-0.5	2.1	-0.1	0.8	0.2
Impedance of leg (right)	0.7	3.2	12.2	-1.1	-0.4	-3.5	-0.5	-1.9	-1.4
Leg fat-free mass (left)	0.8	4.4	9.0	2.3	2.8	1.8	-0.8	0.4	3.0
Trunk fat percentage	1.7	6.7	24.0	1.4	1.6	4.9	-2.7	0.3	2.1
Hand grip strength (right)	1.1	3.1	12.7	-1.2	-0.9	-3.6	1.6	0.0	-1.0
Townsend deprivation index at recruitment	0.5	0.7	2.2	-0.4	-0.6	1.5	0.9	-0.4	-0.7
Current tobacco smoking	0.6	1.0	2.4	0.4	-0.2	1.5	-0.6	-1.5	1.0
Average weekly fortified wine intake	0.4	0.5	1.6	0.4	0.1	-0.1	1.0	1.2	0.5
Maternal smoking around birth	3.4	5.0	12.0	1.8	1.6	3.5	-1.1	-2.6	2.0
Fed-up feelings	1.4	2.5	9.2	-0.1	0.8	-1.2	-1.9	-3.0	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.9	2.6	10.2	-0.4	0.6	-0.7	-2.0	-3.2	0.6
Relative age voice broke	1.5	2.2	6.8	-1.3	-1.5	-2.6	1.2	-0.9	-0.8
Taking other prescription medications	2.1	3.3	5.4	1.3	2.3	1.7	-1.7	-2.1	1.5
Age when periods started (menarche)	1.5	3.7	6.9	1.0	1.8	-2.6	2.4	-1.8	1.4
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.7	0.2	1.3	-0.3	-0.6	0.3	0.5
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.1	5.0	-1.8	-2.0	-1.9	0.4	2.2	-1.7
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	1.3	-1.0	0.2	-0.7	1.2	0.1	-0.3
Qualifications: CSEs or equivalent	1.7	2.3	5.3	-0.9	1.0	-2.1	1.4	-2.3	0.0
Serious illness, injury or assault to yourself	2.6	3.2	10.8	0.8	1.3	3.3	-2.1	-0.5	1.3
High blood pressure	1.1	2.9	5.6	1.7	1.3	2.4	-2.1	-0.2	1.6
Hayfever, allergic rhinitis or eczema	0.7	1.6	4.3	-1.3	-1.4	-2.1	0.2	1.0	-0.7
Multivitamins +/- minerals	0.1	0.1	0.2	0.5	0.1	0.1	0.2	-0.3	0.2
Stomach or abdominal pain in last month	1.6	1.9	4.4	1.1	1.3	-0.7	-1.6	-2.1	1.1
Supplements: Glucosamine	0.8	1.0	2.7	1.0	-0.6	1.3	1.7	0.2	0.3
Diverticular disease/diverticulitis (self-reported)	1.3	1.6	3.6	1.9	1.0	1.3	0.8	1.2	1.0
Medication: Atenolol	2.1	2.6	6.4	1.7	1.5	2.5	-1.3	-0.3	1.6
Medication: Levothyroxine sodium	1.0	1.7	2.7	-1.4	-0.5	-1.1	-1.6	-1.6	-1.2
Sitting height	1.8	13.1	42.5	1.4	4.6	-6.5	-1.1	-1.6	3.0
Chronic bronchitis/emphysema (father)	0.3	0.4	1.8	0.1	0.7	1.4	-0.2	0.3	0.1
High blood pressure (mother)	0.2	0.3	0.5	-0.6	-0.6	-0.3	-0.5	0.1	-0.7
Body mass index (BMI)	1.8	7.7	35.9	1.8	0.7	6.0	-1.0	1.0	2.2
Impedance of leg (left)	0.8	4.1	15.8	-1.5	-0.3	-4.0	-0.3	-1.9	-1.6
Leg predicted mass (left)	0.8	4.3	8.9	2.3	2.8	1.8	-0.8	0.5	3.0
Trunk fat mass	1.5	6.4	18.7	1.9	2.0	4.3	-2.3	0.2	2.6
Waist circumference	2.5	9.1	26.0	2.8	2.5	5.1	-1.5	1.0	3.3
Number of incorrect matches in round	0.3	0.5	2.0	-0.4	0.2	-0.6	1.4	0.6	0.1
Past tobacco smoking	0.8	1.5	3.9	-0.5	-0.7	-1.7	2.0	0.9	-0.8
Alcohol usually taken with meals	0.4	0.7	3.3	0.2	0.4	-0.8	-0.2	1.8	0.3
Nervous feelings	1.9	3.5	18.8	-1.3	0.3	-4.3	-0.3	-0.5	-0.3
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.3	8.8	-1.0	0.1	-1.9	0.1	-3.0	-0.4
Hearing difficulty/problems with background noise	0.6	1.0	1.4	0.9	1.2	0.8	-0.6	-1.1	1.2
Hair/balding pattern: Pattern 2	1.1	1.4	5.0	-0.6	-1.0	0.2	2.2	1.2	-0.7
Had menopause	0.6	0.7	2.0	-0.4	-1.0	-1.4	-0.3	0.6	-0.7
Had other major operations	0.7	0.9	2.4	0.2	0.9	0.3	-1.5	-1.3	0.5
Forced vital capacity (FVC)	1.9	7.4	33.4	-0.1	2.6	-5.8	-0.1	-1.4	1.5
Heel bone mineral density (BMD) T-score, automated (right)	1.9	4.3	7.8	-2.3	-2.8	-2.3	-0.2	1.3	-2.4
Ever unenthusiastic/disinterested for a whole week	2.9	3.5	6.9	1.7	2.5	1.8	-0.1	-1.3	2.6
Qualifications: None of the above	0.5	1.1	2.1	0.8	1.4	-0.2	1.0	-1.0	1.5
Financial difficulties in last 2 years	2.7	3.6	5.3	2.1	2.3	2.1	-0.3	-2.0	1.9
Mouth/teeth dental problems	2.9	4.5	8.2	-2.1	-2.6	-0.6	0.4	2.9	-2.8
Heart attack	0.6	0.8	1.9	0.4	0.5	1.0	-0.9	-1.4	0.8
Allergy	0.9	2.0	3.7	1.9	1.9	1.6	0.5	-0.2	1.4
Pain all over the body in last month	1.9	2.1	6.7	0.4	1.5	0.2	-1.4	-2.6	1.1
Diabetes (self-reported)	3.8	5.9	16.9	2.5	1.9	4.1	-1.6	0.2	2.5
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.2	0.1	0.4	-1.1	-0.1	1.0	0.0
Medication: Ramipril	0.9	1.1	4.2	1.4	0.4	2.1	0.0	-0.1	0.7
Medication: Simvastatin	0.8	1.2	4.8	0.4	0.1	2.2	-1.4	-0.2	0.5
Fluid intelligence score	1.0	2.1	5.5	-0.1	-0.3	2.3	-2.3	1.2	-0.2
Illnesses of siblings	0.3	0.5	1.3	-0.4	-1.1	-0.4	0.7	0.4	-0.7
Neuroticism score	2.3	4.7	14.2	0.9	2.4	-1.4	-1.7	-3.8	1.7
Weight	1.3	6.2	11.2	2.6	2.8	3.2	-1.1	0.4	3.4
Impedance of arm (right)	0.2	0.9	4.6	0.2	0.9	-0.2	-2.1	0.1	0.3
Arm fat percentage (right)	2.2	8.7	39.4	1.5	0.4	6.3	-2.2	1.4	1.8
Trunk fat-free mass	0.4	2.6	5.5	1.9	2.3	-1.0	0.4	-0.1	2.3
Hip circumference	1.2	5.1	17.1	1.8	1.6	4.1	-0.9	1.2	2.4
Time employed in main current job	0.8	0.9	2.7	-0.0	-1.2	0.5	-0.5	1.6	-0.9
Alcohol intake versus 10 years previously	0.4	0.5	2.1	0.2	0.2	0.9	-1.4	-0.2	-0.6
Father’s age at death	1.2	1.6	5.4	-1.4	-0.7	-2.3	0.6	0.7	-1.0
Worrier / anxious feelings	1.2	2.2	6.5	0.5	1.6	-2.6	0.7	-1.7	0.7
Frequency of tiredness / lethargy in last 2 weeks	1.9	3.1	8.3	-1.3	0.2	0.4	-2.8	-2.9	-0.6
Falls in the last year	1.7	2.3	6.3	1.2	1.0	2.5	-1.8	-0.7	1.3
Hair/balding pattern: Pattern 3	1.5	2.2	7.8	0.6	1.2	0.7	-2.8	-1.5	0.9
Number of live births	0.4	0.6	2.4	0.0	-0.6	0.1	1.6	-0.4	-0.7
Forced expiratory volume in 1-second (FEV1)	1.7	5.6	18.8	0.6	3.0	-4.3	0.7	-0.7	2.2
Pulse rate	1.0	1.6	5.3	0.1	0.6	2.0	-2.3	-0.1	0.2
Happiness	0.4	0.5	0.8	0.6	-0.6	-0.5	0.9	-0.9	0.5
Noisy workplace	0.4	0.5	1.0	1.0	0.6	0.0	0.7	-0.5	0.9
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.6	0.1	-0.3	0.8	0.1	0.5	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	2.5	-1.6	-0.6	0.0	-0.3	0.6	-1.0
Mouth/teeth dental problems: Dentures	2.2	3.7	8.4	2.9	1.0	2.4	0.5	-1.3	2.2
Asthma	0.6	1.2	4.0	-0.8	-1.3	0.0	-0.3	-2.0	-0.7
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	3.8	-1.4	-0.6	-0.8	-0.2	-1.9	-1.5
Medication: Cholesterol lowering	0.9	1.4	5.5	-0.6	0.2	1.5	-2.4	-0.3	0.3
Depression (self-reported)	0.9	1.0	5.4	-0.7	0.2	-0.2	-0.3	-2.3	-0.2
Medication: Lansoprazole	1.4	1.6	2.9	0.9	1.5	1.0	-1.7	0.7	1.5
Prospective memory result	0.2	0.3	0.7	0.2	0.5	-0.4	-0.5	-0.5	0.8
Lung cancer (father)	0.5	0.6	1.7	-0.4	-1.1	-0.7	1.3	0.6	-0.2
Illnesses of mother	0.6	0.7	1.7	1.0	0.1	0.2	1.3	1.0	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	1.5	4.9	21.2	0.4	2.2	-4.6	0.6	-0.6	1.5
Pulse wave Arterial Stiffness index	0.1	0.1	0.3	-0.5	0.1	0.0	-0.5	0.3	0.4
Impedance of arm (left)	0.3	1.2	5.4	-0.5	0.8	-0.7	-2.3	-0.2	-0.4
Arm fat mass (right)	1.8	7.3	27.5	2.1	1.4	5.2	-1.8	0.9	2.5
Trunk predicted mass	0.5	2.6	5.5	1.9	2.3	-0.9	0.5	-0.0	2.4
Standing height	1.2	11.8	27.5	2.2	5.1	-5.2	-0.6	-1.8	3.1
Length of working week for main job	1.2	1.3	6.0	0.1	-0.2	1.1	2.5	0.7	-0.0
Exposure to tobacco smoke at home	0.3	0.3	0.6	-0.3	-0.5	-0.6	0.6	-0.8	-0.4
Breastfed as a baby	0.2	0.2	0.5	-0.5	-0.6	-0.4	-0.3	-0.3	-0.7
Tense / ‘highly strung’	1.3	2.2	6.9	0.4	1.2	-1.0	-1.6	-2.6	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	2.2	0.7	1.1	0.0	0.5	-1.5	0.8
Hair/balding pattern: Pattern 4	0.5	1.2	1.9	1.1	1.4	0.9	0.7	-1.0	1.4
Birth weight of first child	0.1	0.1	0.5	0.0	-0.0	0.4	-0.1	0.7	-0.4
Peak expiratory flow (PEF)	0.9	2.1	4.7	0.6	1.5	-2.2	1.7	0.4	1.5
Pulse wave reflection index	0.6	0.7	2.0	0.5	0.7	-0.7	0.0	-1.0	1.4
Ever highly irritable/argumentative for 2 days	1.3	1.5	3.4	0.7	1.9	0.6	-0.6	-1.6	1.4
Loud music exposure frequency	1.4	1.5	3.4	1.7	0.4	0.7	0.8	1.8	1.2
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	1.5	-0.2	0.6	1.2	-0.6	0.4	-0.2
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	2.7	-0.0	1.4	-0.8	-1.7	-0.8	1.2
Blood clot in the leg (DVT)	0.4	0.5	2.0	-0.5	0.1	0.4	-0.7	-1.4	-0.3
Medication: Paracetamol	1.9	3.1	9.8	-0.2	2.1	-0.4	-2.0	-3.1	0.5
Headache pain in last month	1.2	2.0	6.8	-0.9	0.5	-0.5	-2.0	-2.6	-0.4
Medication for cholesterol, blood pressure or diabetes	1.6	2.7	10.7	-0.3	-0.1	-2.3	3.3	-0.0	-0.5
Glaucoma (self-reported)	0.6	0.7	2.3	0.2	1.5	0.6	-0.7	0.9	0.4
Gout (self-reported)	1.4	1.9	3.6	-1.4	-1.8	-0.1	-1.6	0.4	-1.9
Hypothyroidism/myxoedema (self-reported)	1.1	2.1	7.5	-0.9	-0.4	0.0	-2.7	-1.8	-0.8
Medication: Amlodipine	0.3	0.5	2.2	0.3	-0.0	1.5	-0.3	0.2	0.7
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.8	0.3	-1.3	0.4	0.9	0.4	-0.9
Birth weight	0.6	1.4	3.1	0.5	1.8	-1.6	-0.3	-1.5	0.5
Chronic bronchitis/emphysema (mother)	2.4	2.8	6.2	1.0	2.5	0.7	0.4	-2.5	1.7
High blood pressure (siblings)	0.7	1.0	1.6	-1.3	-1.2	-1.1	-0.1	0.6	-1.3
Forced vital capacity (FVC), Best measure	1.9	7.0	33.8	0.1	2.3	-5.8	0.2	-1.2	1.2
Body fat percentage	1.7	6.6	26.6	1.4	1.2	5.2	-2.3	0.3	2.0
Leg fat percentage (right)	1.3	4.7	23.1	1.4	0.1	4.8	-0.9	0.2	1.5
Arm fat-free mass (right)	0.3	1.7	4.2	1.2	2.0	-1.0	0.1	-0.8	1.7
Exposure to tobacco smoke outside home	0.9	1.1	2.8	1.1	0.8	0.3	0.3	-1.4	1.7
Comparative body size at age 10	0.5	1.4	6.1	0.3	-0.8	2.5	-0.7	1.0	0.2
Number of full brothers	1.3	1.6	4.3	-0.6	1.3	-1.7	-0.5	-2.1	0.3
Worry too long after embarrassment	1.4	2.3	6.0	1.7	2.5	-0.4	-0.5	-1.3	1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	1.0	2.5	-0.6	-0.6	-0.4	1.2	-1.6	-0.9
Wheeze or whistling in the chest in last year	1.0	1.8	4.7	1.1	0.7	2.2	-0.9	-0.8	1.8
Number of children fathered	0.7	0.8	2.3	-0.4	0.4	-1.5	-0.4	-1.4	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	2.9	-1.3	0.6	-1.4	-0.3	1.7	-0.6
Age at first live birth	0.7	1.2	2.5	-1.2	-0.7	-1.5	-0.8	0.1	-1.6
Pulse wave peak to peak time	0.1	0.2	0.3	0.6	0.0	-0.3	0.4	-0.4	-0.4
Health satisfaction	0.8	1.1	5.0	0.2	0.1	-0.5	0.8	-2.2	0.7
Shortness of breath walking on level ground	0.4	0.5	1.6	0.4	-0.2	1.3	0.3	0.9	0.4
Qualifications: College or University degree	0.2	0.8	2.2	0.5	-0.0	1.5	-1.3	0.6	-0.2
Eye problems/disorders: None of the above	1.4	1.7	3.7	1.1	1.9	-0.4	1.2	-0.9	1.7
Mouth/teeth dental problems: Loose teeth	0.9	1.1	3.9	-0.8	-0.2	0.1	-1.3	-2.0	-0.3
Emphysema/chronic bronchitis	3.9	4.4	11.0	-2.3	-3.3	-1.3	1.2	0.7	-2.6
Medication for pain relief, constipation, heartburn	1.6	2.8	13.2	0.1	-1.2	-0.1	1.5	3.6	0.1
Neck or shoulder pain in last month	1.4	2.0	4.9	0.9	1.5	1.1	-1.1	-2.2	1.2
Medication: Blood pressure	1.4	2.5	9.5	0.6	-0.3	2.3	-3.1	-0.0	0.3
Angina (self-reported)	1.6	2.2	4.3	0.6	1.6	1.6	-2.1	-1.2	1.3
Migraine (self-reported)	0.6	0.7	3.4	0.0	0.8	0.1	0.0	-1.8	0.5
Medication: Ibuprofen	0.5	0.7	2.8	-0.6	-0.2	0.1	0.5	-1.7	-0.7
Medication: Allopurinol	2.2	2.9	5.6	-1.8	-2.4	-0.1	-1.6	0.6	-2.4
Medication: Omeprazole	1.1	1.3	2.3	1.5	0.8	1.5	0.9	0.5	1.0
Medication: Seretide 50 evohaler	1.3	1.6	3.4	-0.6	-1.6	0.9	1.8	1.0	-1.1
Mean time to correctly identify matches	0.1	0.2	0.8	-0.1	0.1	-0.9	-0.2	-0.2	0.3
Heart disease (mother)	0.4	0.5	1.6	-0.8	0.0	-1.3	0.2	-0.7	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	2.0	-0.3	-0.0	0.5	-0.1	-1.4	0.3
Whole body fat mass	1.6	6.5	22.4	1.9	1.6	4.7	-1.9	0.2	2.5
Leg fat mass (right)	1.4	5.3	19.5	1.8	1.3	4.4	-1.5	0.2	2.3
Arm predicted mass (right)	0.4	2.2	5.4	1.5	2.3	-0.7	0.2	-0.6	2.2
Pulse rate, automated reading	1.0	3.1	8.3	-1.2	-1.3	2.2	-2.9	-0.6	-1.6
Alcohol intake frequency.	0.3	0.7	2.2	0.1	-0.0	1.2	1.5	0.0	-0.5
Comparative height size at age 10	0.8	4.6	10.6	1.8	3.2	-0.2	-1.7	-1.4	3.0
Number of full sisters	0.2	0.3	0.9	-0.1	0.8	-1.0	-0.2	-0.1	-0.1
Suffer from ‘nerves’	0.8	1.2	5.8	-0.3	0.9	-2.4	-0.1	-0.4	0.4
Overall health rating	0.8	1.7	6.9	0.9	0.7	0.9	-0.3	-2.6	1.2
Chest pain or discomfort	2.7	3.9	6.9	1.0	2.6	1.6	-1.3	-2.6	2.2
Had major operations	3.1	3.7	4.9	1.6	2.2	2.0	-2.1	-1.2	2.2
Age at last live birth	0.3	0.5	1.0	-0.3	-0.2	-0.1	-1.0	-0.8	-1.0
Family relationship satisfaction	0.4	0.4	1.0	0.4	-0.1	0.8	-1.0	-0.9	0.3
Leg pain on walking	0.6	0.8	1.1	1.0	0.8	1.0	0.5	-1.0	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.8	-0.4	-0.2	-1.3	-0.3	-0.6	-0.2
Commuting to job workplace: Car/motor vehicle	0.7	0.8	2.3	1.1	0.2	1.5	-0.6	-0.9	0.0
Illness, injury, bereavement, stress in last 2 years	1.1	1.3	2.7	-1.0	-1.5	-1.7	0.8	0.6	-0.8
Medication: Aspirin	0.7	0.9	2.6	0.1	0.7	1.4	-1.6	-0.6	0.2
Supplements: Vitamin C	1.3	1.5	3.7	0.7	1.6	-1.3	0.9	0.1	1.9
Knee pain experienced in last month	4.3	6.7	15.1	3.1	2.3	3.9	0.4	-0.9	3.1
Hypertension (Self-reported)	1.0	2.8	6.3	1.7	1.1	2.5	-2.1	0.3	1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.7	2.0	3.6	1.4	1.9	1.7	-1.1	-0.3	1.4
Illnesses of father: Heart disease	1.6	2.2	7.0	-1.6	-0.1	-0.9	-1.3	-2.6	-1.2
Illnesses of siblings: Diabetes	1.1	1.3	2.3	0.8	1.4	1.0	-0.2	-1.5	1.4
Smoking status: Previous	1.5	2.2	4.6	1.1	1.4	1.7	-2.1	-1.3	1.1
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.1	5.0	1.8	2.2	-0.8	0.6	-0.8	1.5
Whole body fat-free mass	0.5	2.9	6.8	2.1	2.6	0.1	-0.2	0.0	2.6
Leg fat-free mass (right)	0.7	3.7	7.8	2.1	2.8	1.4	-0.6	0.5	2.8
Arm fat percentage (left)	1.9	7.8	35.8	1.1	0.3	6.0	-2.4	1.4	1.4
Average weekly red wine intake	0.3	0.4	0.8	0.6	0.9	-0.1	-0.7	0.5	0.8
Handedness (chirality/laterality): Left-handed	3.8	4.6	9.9	3.2	2.5	1.1	1.0	0.1	3.0
Mood swings	1.8	3.3	12.0	-0.2	0.5	-1.2	-2.5	-3.5	0.0
Loneliness, isolation	4.1	5.6	15.8	1.9	2.3	1.0	-1.1	-4.0	2.5
Long-standing illness, disability or infirmity	1.6	2.5	5.8	0.9	1.2	2.4	-2.3	0.3	1.2
Ever had bowel cancer screening	0.4	0.5	1.0	0.1	0.8	-1.0	-0.8	0.1	0.7
Diabetes diagnosed by doctor	3.0	4.9	16.0	2.1	1.4	4.0	-1.8	-0.4	1.9
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	2.5	-1.2	-0.5	-0.8	1.6	0.0	-0.6
Friendships satisfaction	0.2	0.2	0.7	0.0	-0.8	-0.6	0.3	-0.5	0.0
Qualifications: nursing, teaching	0.9	1.4	4.7	0.5	-0.3	2.2	1.3	1.2	-0.3
Commuting to job workplace: Walk	0.9	0.9	2.3	-1.5	-0.8	-1.0	0.9	-0.4	-0.9
Eye problems/disorders: Cataract	2.1	2.4	7.0	-1.5	-2.6	-0.1	-1.5	-0.1	-1.7
Mouth/teeth dental problems: Mouth ulcers	0.7	1.0	2.5	0.5	1.3	-0.2	-1.2	-1.6	0.6
Medication for cholesterol	0.7	1.1	2.8	-0.8	-0.8	-0.3	1.7	1.4	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.8	2.2	6.6	-1.2	-1.2	-1.4	0.5	-2.6	-1.1
Back pain experienced in last month	1.6	2.3	7.8	1.0	0.7	-1.4	1.2	-2.8	1.3
Mineral and other dietary supplements	0.8	1.0	1.8	-1.2	-0.5	-1.2	-1.3	-0.3	-1.1
Breast cancer (self-reported)	0.4	0.5	2.2	-0.5	-0.1	0.1	-0.4	-1.5	-0.6
Asthma (self-reported)	0.5	1.1	5.0	-0.5	-0.9	0.1	-0.3	-2.2	-0.3
Osteoporosis (self-reported)	0.5	0.7	1.6	1.3	0.4	0.9	-1.0	-0.2	0.5
Osteoarthritis (self-reported)	2.1	2.7	4.9	1.7	1.9	2.2	-0.8	-0.7	1.9
Medication: Aspirin	1.0	1.3	3.4	0.6	1.0	1.8	-1.4	-0.6	0.8
Medication: Gliclazide	0.8	0.9	2.5	0.7	1.0	1.6	-1.0	-0.1	0.6
Illnesses of father: None of the above (group 1)	0.9	1.1	2.6	1.6	-0.3	-0.0	1.3	0.8	1.2
Smoking status: Current	0.7	1.1	2.9	0.3	-0.2	1.6	-0.7	-1.7	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	2.0	6.0	0.2	1.1	-2.4	1.8	-0.3	1.2
Whole body water mass	0.5	3.0	6.9	2.0	2.6	0.0	-0.2	-0.1	2.6
Leg predicted mass (right)	0.7	3.9	8.4	2.1	2.9	1.4	-0.7	0.4	2.8
Arm fat mass (left)	1.5	6.0	23.7	1.6	1.0	4.9	-2.0	0.8	2.0
Number of self-reported non-cancer illnesses	2.0	3.4	10.7	0.7	1.3	2.4	-3.3	-1.1	0.9
Average weekly champagne plus white wine intake	1.4	1.9	3.6	-1.4	-1.6	-1.9	0.2	1.1	-1.4
Miserableness	1.2	2.1	8.4	-0.5	0.9	-0.4	-1.7	-2.9	0.1
Guilty feelings	1.4	2.1	7.7	0.7	1.6	-0.8	0.8	-2.8	0.9
Wears glasses or contact lenses	0.7	0.8	1.7	1.1	-0.2	1.3	-0.8	1.1	0.1
Ever taken oral contraceptive pill	0.5	0.6	1.4	0.6	0.9	1.2	-0.8	-0.3	0.2
Hearing aid user	0.8	0.9	2.9	-0.4	-1.0	0.9	0.6	-1.7	-0.4
Mother’s age at death	0.5	0.6	1.2	0.1	0.8	-0.9	-1.1	0.6	0.7
Financial situation satisfaction	0.8	1.0	2.9	0.4	-0.1	-0.6	1.5	-1.7	0.3
Tinnitus: Yes, now most or all of the time	0.6	0.7	2.0	1.4	0.4	0.9	0.6	-0.3	0.8
Commuting to job workplace: Public transport	0.6	0.7	2.4	-0.3	-0.6	-0.2	-1.1	1.6	0.2
Eye problems/disorders: Glaucoma	0.8	0.9	2.6	0.8	1.6	0.8	-0.5	0.8	0.9
Medication: Blood pressure	0.7	1.3	2.6	1.2	1.1	1.3	-1.6	0.5	0.9
Pain type(s) experienced in last month: Hip pain	2.9	3.6	8.1	1.1	2.1	1.3	-2.8	-1.3	2.2
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.9	0.9	0.2	0.6	0.7	-0.2	0.7
High cholesterol (Self-reported)	0.2	0.4	0.7	-0.6	-0.7	0.7	-0.8	0.4	-0.6
Medication: Bendroflumethiazide	0.3	0.4	0.7	0.4	0.9	0.8	-0.4	0.5	0.6
Medication: Paracetamol	1.1	1.7	7.3	-0.2	1.3	-0.1	-1.1	-2.7	0.1
Medication: Lisinopril	0.8	1.0	2.4	-0.2	-1.4	1.5	-1.0	-0.5	-0.7
Medication: Atorvastatin	0.4	0.5	2.7	-0.2	-0.1	0.3	-0.4	1.6	0.2
Illnesses of father: High blood pressure	0.5	0.6	1.5	-1.2	1.2	-0.9	-0.1	-0.1	-0.1
Alcohol drinker status: Never	0.1	0.1	0.1	-0.0	0.2	0.4	0.3	0.3	-0.4
Ever smoked	0.3	0.4	1.0	0.3	0.4	1.0	-0.8	-0.1	0.9
Basal metabolic rate	0.6	3.2	7.3	2.1	2.6	0.8	-0.4	0.1	2.7
Leg fat percentage (left)	1.2	4.3	21.5	1.2	0.1	4.6	-0.8	0.2	1.4
Arm fat-free mass (left)	0.5	2.5	5.5	1.9	2.3	-0.2	0.1	-0.6	2.4
Number of operations (self-reported)	2.2	3.3	7.8	1.0	2.4	1.0	-2.8	-1.6	1.3
Average weekly beer plus cider intake	0.5	0.7	1.4	-1.2	-0.6	-0.6	0.7	-0.5	-1.0
Irritability	1.4	2.3	6.3	0.3	0.9	0.3	-2.4	-2.5	0.9
Risk taking	0.7	1.0	2.4	0.3	0.9	1.2	-1.6	-0.7	0.8
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.9	0.1	-0.8	-0.1	0.6	-1.0	0.1
Fractured/broken bones in last 5 years	0.7	0.9	2.5	1.4	0.4	1.6	-0.8	0.5	0.3
Age started oral contraceptive pill	0.9	1.1	2.8	0.4	-0.3	-1.4	1.7	1.2	0.1
Diastolic blood pressure, automated reading	0.8	2.4	4.5	1.8	1.3	0.8	-2.1	0.9	1.9
Ever depressed for a whole week	0.5	0.6	1.1	0.7	0.6	1.1	-0.9	-0.1	0.9
Unable to work because of sickness or disability	0.5	0.7	1.7	-1.2	0.1	0.3	-0.7	-1.3	-0.4
Commuting to job workplace: Cycle	2.5	3.0	6.0	-1.8	-1.7	-2.5	-0.4	1.6	-1.8
Myopia	1.0	1.5	3.5	1.4	1.9	0.0	-0.5	0.6	1.7
Vascular/heart problems diagnosed by doctor	1.4	3.9	7.7	-2.0	-1.5	-2.8	2.5	0.9	-1.6
Cholesterol lowering medication	0.8	1.2	3.7	1.0	0.4	1.9	0.8	0.8	0.9
Medication: Omeprazole (e.g. Zanprol)	1.6	2.0	3.8	2.0	1.7	1.5	0.4	-0.2	1.6
Pain experienced in last month	2.0	3.3	10.4	-0.9	-2.0	-0.2	0.6	3.2	-2.1
Supplements: Calcium	0.2	0.2	0.6	0.8	-0.2	0.1	-0.6	0.1	0.3
Basal cell carcinoma (self-reported)	1.4	1.6	4.0	2.0	0.9	1.6	0.2	1.3	0.9
Heart attack/myocardial infarction (self-reported)	0.7	0.9	2.3	0.4	0.5	1.0	-1.1	-1.5	0.7
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.3	-0.6	-0.1	0.3	-0.7	-1.1	-0.4
Heart disease (siblings)	0.6	0.8	1.4	0.7	1.1	1.2	-0.8	0.0	1.0
Alcohol drinker status: Previous	0.2	0.3	0.5	-0.5	0.3	0.7	-0.3	0.4	-0.7
Pack years of smoking	0.8	1.2	5.0	0.9	-0.3	2.2	0.0	1.1	0.5
Impedance of whole body	0.5	2.5	7.0	-1.4	0.2	-2.6	-1.7	-1.2	-1.3
Leg fat mass (left)	1.3	5.0	18.3	1.7	1.3	4.3	-1.3	0.2	2.3
Arm predicted mass (left)	0.5	2.3	5.3	1.9	2.2	-0.1	0.0	-0.4	2.3