[Hub]/) : Traits : Forced vital capacity (FVC) :

chr16:29,580,611-31,833,122

Best TWAS P=3.73e-14 · Best GWAS P=2.33e-12 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex HSD3B7 0.05 0.06 lasso 4 0.07 5.5e-09 -6.0 -6.0 1.5e-09 0.34 0.56 0.44 FALSE
2 GTEx Adipose Subcutaneous RP11-196G11.2 0.23 0.20 lasso 9 0.21 4.2e-17 -6.1 -6.2 5.4e-10 0.38 0.45 0.55 FALSE
3 GTEx Adipose Visceral Omentum KAT8 0.07 0.02 lasso 5 0.02 4.0e-02 5.1 -5.1 2.7e-07 0.18 0.38 0.04 FALSE
4 GTEx Adipose Visceral Omentum RP11-196G11.2 0.08 0.07 enet 16 0.08 8.4e-05 -5.9 -5.7 1.5e-08 0.31 0.56 0.36 FALSE
5 GTEx Adrenal Gland HSD3B7 0.21 0.17 lasso 4 0.13 2.9e-05 -6.0 -5.5 3.2e-08 0.37 0.32 0.25 FALSE
6 GTEx Artery Aorta STX1B 0.17 0.18 lasso 6 0.15 1.9e-08 -5.9 -6.0 2.2e-09 0.36 0.57 0.42 FALSE
7 GTEx Artery Aorta RP11-196G11.2 0.10 0.16 lasso 2 0.14 7.1e-08 -6.1 -6.1 8.1e-10 0.38 0.47 0.52 FALSE
8 GTEx Artery Coronary RP11-196G11.2 0.12 0.06 lasso 6 0.06 3.4e-03 -6.1 -6.7 2.8e-11 0.48 0.09 0.74 FALSE
9 GTEx Artery Tibial RP11-196G11.2 0.08 0.04 lasso 4 0.03 3.8e-03 -6.1 -5.3 1.0e-07 0.27 0.41 0.48 FALSE
10 GTEx Brain Cerebellar Hemisphere STX1B 0.13 0.11 lasso 5 0.10 1.5e-03 -5.8 -5.9 3.7e-09 0.39 0.10 0.26 FALSE
11 GTEx Brain Cerebellar Hemisphere RP11-196G11.2 0.18 0.06 lasso 6 0.10 1.7e-03 -6.0 -6.3 4.1e-10 0.33 0.12 0.52 FALSE
12 GTEx Brain Cerebellum STX1B 0.24 0.16 lasso 11 0.18 4.8e-06 -6.2 -5.7 1.6e-08 0.36 0.44 0.48 TRUE
13 GTEx Brain Cerebellum STX4 0.14 0.25 lasso 1 0.24 8.3e-08 -6.0 -6.0 2.1e-09 0.37 0.40 0.51 FALSE
14 GTEx Brain Cerebellum RP11-196G11.2 0.31 0.30 lasso 4 0.36 1.3e-11 -6.0 -6.1 9.9e-10 0.38 0.42 0.58 FALSE
15 GTEx Brain Nucleus accumbens basal ganglia STX4 0.19 0.11 enet 14 0.09 2.6e-03 -6.0 6.3 3.6e-10 -0.54 0.07 0.55 FALSE
16 GTEx Breast Mammary Tissue STX1B 0.08 0.00 enet 11 0.02 5.1e-02 -3.8 -5.1 2.9e-07 0.29 0.11 0.40 FALSE
17 GTEx Breast Mammary Tissue RP11-196G11.2 0.13 0.16 lasso 4 0.17 5.0e-09 -6.2 -6.2 5.3e-10 0.37 0.35 0.65 FALSE
18 GTEx Breast Mammary Tissue (Male) RP11-196G11.2 0.15 0.16 lasso 4 0.09 3.9e-03 -6.2 -6.2 5.0e-10 0.36 0.28 0.34 FALSE
19 GTEx Cells Transformed fibroblasts RP11-196G11.2 0.14 0.14 lasso 6 0.13 2.9e-10 -5.9 -6.2 6.7e-10 0.38 0.54 0.46 FALSE
20 GTEx Colon Transverse HSD3B7 0.16 0.15 enet 20 0.19 2.1e-09 -5.9 -5.4 6.3e-08 0.38 0.59 0.41 FALSE
21 GTEx Colon Transverse STX4 0.10 0.09 lasso 3 0.06 6.6e-04 -6.2 -6.2 5.5e-10 0.36 0.24 0.38 FALSE
22 GTEx Colon Transverse RP11-196G11.2 0.24 0.11 lasso 5 0.15 1.9e-07 -6.1 -6.0 2.4e-09 0.33 0.48 0.52 FALSE
23 GTEx Esophagus Gastroesophageal Junction RP11-196G11.2 0.13 0.11 enet 8 0.14 1.2e-05 -6.1 -6.0 2.2e-09 0.35 0.42 0.45 FALSE
24 GTEx Esophagus Mucosa STX1B 0.12 0.03 lasso 5 0.05 1.7e-04 -6.1 -5.2 2.6e-07 0.38 0.35 0.60 FALSE
25 GTEx Esophagus Mucosa HSD3B7 0.38 0.32 lasso 5 0.36 1.2e-24 -6.0 -5.8 6.7e-09 0.33 0.67 0.33 FALSE
26 GTEx Esophagus Mucosa STX4 0.08 0.00 enet 21 0.02 1.0e-02 -6.0 -6.9 5.3e-12 0.72 0.05 0.92 TRUE
27 GTEx Esophagus Mucosa BCKDK 0.05 0.05 enet 6 0.06 8.7e-05 4.4 5.3 9.7e-08 -0.28 0.43 0.06 FALSE
28 GTEx Esophagus Mucosa RP11-196G11.2 0.09 0.03 enet 13 0.05 1.5e-04 -6.1 -6.8 1.2e-11 0.46 0.26 0.59 FALSE
29 GTEx Esophagus Muscularis STX4 0.05 0.05 lasso 3 0.03 6.7e-03 -6.1 -6.1 9.7e-10 0.37 0.28 0.44 FALSE
30 GTEx Esophagus Muscularis RP11-196G11.2 0.14 0.14 lasso 6 0.13 3.7e-08 -6.1 -6.2 7.5e-10 0.35 0.52 0.48 FALSE
31 GTEx Heart Atrial Appendage KAT8 0.12 0.02 lasso 4 0.01 1.6e-01 4.9 -5.2 1.7e-07 0.32 0.12 0.08 FALSE
32 GTEx Heart Left Ventricle HSD3B7 0.12 0.08 lasso 3 0.07 2.0e-04 -5.9 -6.2 7.3e-10 0.40 0.54 0.32 FALSE
33 GTEx Lung RP11-196G11.2 0.21 0.12 enet 22 0.14 1.6e-10 -6.1 -5.3 1.4e-07 0.40 0.37 0.63 FALSE
34 GTEx Muscle Skeletal HSD3B7 0.15 0.13 enet 19 0.14 5.5e-14 -6.0 -5.9 4.5e-09 0.37 0.55 0.45 FALSE
35 GTEx Muscle Skeletal STX4 0.04 0.04 lasso 3 0.03 2.9e-04 -5.9 -5.8 7.9e-09 0.32 0.51 0.42 FALSE
36 GTEx Muscle Skeletal RP11-196G11.2 0.15 0.10 enet 10 0.12 1.0e-11 -6.2 -5.7 1.6e-08 0.39 0.45 0.55 FALSE
37 GTEx Nerve Tibial STX1B 0.21 0.14 enet 17 0.18 1.6e-12 -6.2 -6.1 7.9e-10 0.39 0.38 0.62 FALSE
38 GTEx Nerve Tibial HSD3B7 0.09 0.05 lasso 3 0.03 2.4e-03 -6.1 -5.9 3.2e-09 0.38 0.20 0.25 FALSE
39 GTEx Nerve Tibial STX4 0.07 0.04 enet 16 0.04 9.4e-04 -6.1 -5.7 9.3e-09 0.37 0.54 0.30 FALSE
40 GTEx Nerve Tibial RP11-196G11.2 0.17 0.22 lasso 6 0.22 2.3e-15 -6.1 -6.7 2.4e-11 0.48 0.51 0.49 FALSE
41 GTEx Ovary RP11-196G11.2 0.41 0.22 lasso 10 0.25 6.0e-07 -6.2 -6.2 6.0e-10 0.41 0.51 0.46 FALSE
42 GTEx Pancreas STX1B 0.23 0.18 lasso 3 0.16 2.8e-07 -6.2 -6.2 5.5e-10 0.36 0.36 0.64 FALSE
43 GTEx Pancreas RP11-196G11.2 0.13 0.11 lasso 1 0.11 2.5e-05 -6.1 -6.1 1.0e-09 0.37 0.36 0.52 FALSE
44 GTEx Pituitary HSD3B7 0.13 0.07 lasso 7 0.05 2.1e-02 -5.8 -5.9 3.5e-09 0.39 0.30 0.17 FALSE
45 GTEx Pituitary RP11-196G11.2 0.21 0.28 lasso 6 0.23 1.4e-06 -6.1 -6.0 1.7e-09 0.38 0.39 0.42 FALSE
46 GTEx Skin Not Sun Exposed Suprapubic HSD3B7 0.11 0.12 enet 6 0.10 5.9e-06 -6.0 -5.7 1.3e-08 0.33 0.67 0.31 FALSE
47 GTEx Skin Not Sun Exposed Suprapubic RP11-196G11.2 0.22 0.21 lasso 9 0.26 3.2e-14 -6.1 -6.5 1.1e-10 0.44 0.48 0.52 FALSE
48 GTEx Skin Sun Exposed Lower leg STX1B 0.05 0.04 enet 4 0.05 7.2e-05 -6.2 -6.2 6.6e-10 0.37 0.37 0.55 FALSE
49 GTEx Skin Sun Exposed Lower leg HSD3B7 0.12 0.17 lasso 5 0.16 2.7e-13 -6.0 -6.0 2.1e-09 0.39 0.68 0.32 FALSE
50 GTEx Skin Sun Exposed Lower leg RP11-196G11.2 0.16 0.15 lasso 7 0.15 4.0e-12 -6.2 -6.8 1.4e-11 0.49 0.45 0.55 FALSE
51 GTEx Small Intestine Terminal Ileum RP11-196G11.2 0.18 0.07 enet 15 0.06 1.5e-02 -6.1 -5.8 5.2e-09 0.44 0.08 0.36 FALSE
52 GTEx Stomach RP11-196G11.2 0.25 0.16 enet 21 0.14 4.6e-07 -5.4 -6.2 6.7e-10 0.67 0.20 0.80 FALSE
53 GTEx Testis STX1B 0.26 0.23 lasso 5 0.25 1.2e-11 -6.0 -5.8 8.7e-09 0.37 0.49 0.51 FALSE
54 GTEx Testis STX4 0.15 0.02 lasso 6 0.01 8.2e-02 -6.0 -6.1 1.2e-09 0.39 0.12 0.33 FALSE
55 GTEx Testis RP11-196G11.2 0.14 0.11 lasso 4 0.13 3.1e-06 -6.1 -6.2 7.0e-10 0.37 0.46 0.52 FALSE
56 GTEx Thyroid STX1B 0.11 0.16 enet 19 0.16 3.9e-12 -6.0 -6.0 1.6e-09 0.37 0.47 0.53 FALSE
57 GTEx Thyroid MIR4519 0.09 0.00 lasso 6 0.01 3.7e-02 -6.9 7.6 3.7e-14 -0.98 0.01 0.92 TRUE
58 GTEx Thyroid RP11-196G11.2 0.11 0.14 lasso 2 0.14 3.5e-11 -6.1 -6.2 6.9e-10 0.37 0.40 0.60 FALSE
59 GTEx Uterus TBX6 0.29 0.04 lasso 6 0.10 4.5e-03 3.9 5.9 3.4e-09 -0.24 0.02 0.64 TRUE
60 GTEx Uterus RP11-196G11.2 0.18 0.16 lasso 20 0.15 5.4e-04 -6.1 -6.1 8.6e-10 0.40 0.37 0.35 FALSE
61 GTEx Whole Blood RP11-196G11.2 0.07 0.05 lasso 3 0.06 1.4e-06 -6.1 -7.0 2.1e-12 0.58 0.29 0.70 FALSE
62 METSIM Adipose RP11-196G11.2 0.13 0.17 lasso 9 0.16 2.2e-23 -6.0 -6.0 1.8e-09 0.35 0.54 0.46 FALSE
63 NTR Blood BCKDK 0.01 0.00 bslmm 242 0.01 2.5e-03 4.9 5.3 9.4e-08 -0.30 0.41 0.04 TRUE
64 ROSMAP Brain Pre-frontal Cortex STX1B 0.08 0.10 lasso 7 0.10 3.0e-12 -5.9 -5.9 4.1e-09 0.40 0.78 0.22 FALSE
65 ROSMAP Brain Pre-frontal Cortex HSD3B7 0.03 0.05 lasso 6 0.02 3.0e-04 -6.0 -5.8 5.0e-09 0.30 0.50 0.47 FALSE
66 ROSMAP Brain Pre-frontal Cortex STX4 0.06 0.11 lasso 10 0.11 1.4e-13 -6.0 6.0 2.6e-09 -0.38 0.51 0.49 FALSE
67 ROSMAP Brain Pre-frontal Cortex VKORC1 0.05 0.02 enet 12 0.05 1.2e-06 -5.1 5.8 8.4e-09 -0.47 0.40 0.58 TRUE
68 ROSMAP Brain Pre-frontal Cortex RP11-196G11.2 0.12 0.12 lasso 4 0.12 1.1e-14 -6.0 -6.0 1.9e-09 0.34 0.46 0.55 FALSE
69 YFS Blood STX4 0.03 0.06 lasso 2 0.05 4.3e-17 -5.9 -6.0 2.5e-09 0.36 0.42 0.58 FALSE
70 The Cancer Genome Atlas Bladder Urothelial Carcinoma HSD3B7 0.04 0.02 enet 13 0.03 2.1e-03 -5.9 -6.9 3.7e-12 0.65 0.02 0.53 FALSE
71 The Cancer Genome Atlas Breast Invasive Carcinoma HSD3B7 0.03 0.03 blup 31 0.04 5.2e-08 -5.9 -5.3 1.1e-07 0.24 0.06 0.94 FALSE
72 The Cancer Genome Atlas Breast Invasive Carcinoma PRSS53 0.03 0.03 blup 38 0.02 6.8e-06 -6.1 5.1 2.9e-07 -0.23 0.01 0.99 FALSE
73 The Cancer Genome Atlas Glioblastoma Multiforme MYST1 0.18 0.07 blup 35 0.11 4.2e-04 4.4 -5.9 4.7e-09 0.28 0.05 0.70 FALSE
74 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma BCL7C 0.04 0.01 blup 29 0.02 6.9e-03 -6.0 7.4 1.3e-13 -0.72 0.04 0.48 TRUE
75 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma MYST1 0.08 0.04 blup 34 0.07 7.2e-08 5.1 -5.6 2.0e-08 0.20 0.01 0.99 FALSE
76 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma ZNF668 0.02 0.02 blup 32 0.02 2.9e-03 4.4 5.1 2.8e-07 -0.19 0.10 0.55 FALSE
77 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma RNF40 0.07 0.00 blup 11 0.02 2.8e-02 -6.9 5.6 2.3e-08 -0.82 0.00 0.49 TRUE
78 The Cancer Genome Atlas Brain Lower Grade Glioma PRSS53 0.07 0.04 enet 12 0.04 2.8e-05 -6.2 5.5 4.6e-08 -0.32 0.01 0.99 FALSE
79 The Cancer Genome Atlas Brain Lower Grade Glioma ZNF668 0.02 0.01 enet 8 0.02 3.1e-03 4.4 5.9 3.8e-09 -0.29 0.03 0.68 FALSE
80 The Cancer Genome Atlas Liver Hepatocellular Carcinoma HSD3B7 0.08 0.05 blup 31 0.05 1.8e-03 -6.0 -5.5 3.4e-08 0.33 0.06 0.85 FALSE
81 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma HSD3B7 0.04 0.04 blup 31 0.05 3.6e-04 -6.0 -5.6 2.8e-08 0.27 0.03 0.77 FALSE
82 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma MYST1 0.03 0.05 blup 34 0.03 2.1e-03 4.4 -5.4 6.5e-08 0.21 0.08 0.62 FALSE
83 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma STX1B 0.02 0.01 blup 32 0.01 5.5e-02 -6.2 -6.3 2.2e-10 0.41 0.02 0.52 FALSE
84 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma HSD3B7 0.09 0.12 blup 31 0.11 4.1e-05 -5.9 -6.2 5.9e-10 0.41 0.06 0.88 FALSE
85 The Cancer Genome Atlas Prostate Adenocarcinoma HSD3B7 0.24 0.27 lasso 6 0.26 2.0e-27 -6.0 -6.0 2.4e-09 0.40 0.06 0.94 TRUE
86 The Cancer Genome Atlas Prostate Adenocarcinoma PRSS53 0.06 0.02 enet 7 0.04 4.7e-05 -6.1 5.9 3.4e-09 -0.36 0.01 0.99 FALSE
87 The Cancer Genome Atlas Prostate Adenocarcinoma STX1B 0.04 0.03 blup 32 0.04 9.5e-05 -5.9 -5.7 1.0e-08 0.39 0.06 0.92 FALSE
88 The Cancer Genome Atlas Thyroid Carcinoma HSD3B7 0.20 0.27 lasso 12 0.28 1.8e-27 -5.9 -5.8 6.1e-09 0.37 0.08 0.92 FALSE
89 The Cancer Genome Atlas Thyroid Carcinoma PRSS53 0.11 0.04 enet 8 0.05 9.7e-06 -5.9 6.3 3.5e-10 -0.52 0.01 0.97 FALSE