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chr12:109,670,468-113,517,494

Best TWAS P=8.86e-21 · Best GWAS P=2.55e-18 conditioned to 0.00617

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ALDH2	0.05	0.11	blup	223	0.10	1.8e-12	-5.3	6.2	5.0e-10	0.42	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	ATXN2	0.02	0.03	enet	8	0.02	4.8e-04	-6.6	7.9	3.6e-15	0.56	0.25	0.66	FALSE
3	GTEx	Adipose Subcutaneous	HECTD4	0.06	0.00	enet	15	0.02	1.0e-02	-5.2	6.2	6.7e-10	0.65	0.07	0.82	FALSE
4	GTEx	Adipose Subcutaneous	MAPKAPK5-AS1	0.08	0.01	enet	26	0.03	2.1e-03	-7.1	-6.6	4.6e-11	-0.44	0.96	0.03	FALSE
5	GTEx	Adipose Subcutaneous	AC003029.1	0.08	0.07	enet	30	0.05	1.2e-04	-5.3	-6.6	3.9e-11	-0.47	1.00	0.00	FALSE
6	GTEx	Adrenal Gland	MAPKAPK5-AS1	0.10	0.08	lasso	12	0.03	3.0e-02	-5.3	-5.4	6.2e-08	-0.39	0.55	0.07	FALSE
7	GTEx	Adrenal Gland	AC003029.1	0.12	0.10	lasso	13	0.07	2.0e-03	-5.3	-5.4	6.8e-08	-0.39	0.79	0.04	FALSE
8	GTEx	Artery Aorta	AC003029.1	0.07	0.01	lasso	7	0.01	5.4e-02	-7.2	-6.1	1.1e-09	-0.43	0.23	0.16	FALSE
9	GTEx	Artery Tibial	ALDH2	0.08	0.09	lasso	2	0.07	2.7e-06	-5.2	5.5	3.6e-08	0.41	0.94	0.03	FALSE
10	GTEx	Artery Tibial	HECTD4	0.05	0.02	lasso	3	0.01	3.1e-02	7.0	6.7	2.4e-11	0.78	0.02	0.91	FALSE
11	GTEx	Artery Tibial	AC003029.1	0.05	0.04	lasso	12	0.03	3.6e-03	-5.3	-5.4	8.5e-08	-0.38	0.58	0.04	FALSE
12	GTEx	Brain Cerebellar Hemisphere	NAA25	0.11	0.02	enet	10	0.00	2.5e-01	-4.2	-6.0	2.3e-09	-0.33	0.14	0.06	FALSE
13	GTEx	Brain Cerebellum	NAA25	0.12	-0.01	lasso	12	0.00	3.0e-01	-4.4	-5.9	2.9e-09	-0.34	0.12	0.07	FALSE
14	GTEx	Brain Frontal Cortex BA9	ALDH2	0.33	0.04	enet	24	0.09	2.0e-03	-6.8	5.6	1.7e-08	0.33	0.09	0.08	FALSE
15	GTEx	Brain Frontal Cortex BA9	TMEM116	0.10	0.09	lasso	7	0.18	1.9e-05	-5.4	-5.4	6.7e-08	-0.36	0.38	0.04	FALSE
16	GTEx	Brain Putamen basal ganglia	ALDH2	0.12	0.00	lasso	14	0.02	1.3e-01	-6.7	6.1	1.1e-09	0.39	0.16	0.18	FALSE
17	GTEx	Breast Mammary Tissue	HECTD4	0.06	0.08	lasso	1	0.07	1.6e-04	-5.3	5.3	1.2e-07	0.38	0.30	0.22	FALSE
18	GTEx	Cells Transformed fibroblasts	HECTD4	0.04	0.01	lasso	5	0.00	4.5e-01	-4.3	5.3	1.1e-07	0.35	0.20	0.10	FALSE
19	GTEx	Cells Transformed fibroblasts	MAPKAPK5-AS1	0.06	0.04	lasso	12	0.02	9.5e-03	-5.3	-5.3	9.6e-08	-0.38	0.53	0.03	FALSE
20	GTEx	Cells Transformed fibroblasts	AC003029.1	0.06	0.05	lasso	1	0.03	2.1e-03	-5.3	-5.3	1.2e-07	-0.38	0.66	0.02	FALSE
21	GTEx	Colon Sigmoid	MAPKAPK5-AS1	0.17	0.05	lasso	15	0.07	1.5e-03	-5.3	-5.5	4.9e-08	-0.37	0.51	0.05	FALSE
22	GTEx	Colon Sigmoid	AC003029.1	0.17	0.08	lasso	14	0.09	3.8e-04	-5.3	-5.3	8.9e-08	-0.35	0.60	0.06	FALSE
23	GTEx	Colon Transverse	FAM109A	0.21	0.00	lasso	4	0.01	1.3e-01	-6.9	6.2	5.9e-10	0.41	0.06	0.06	FALSE
24	GTEx	Colon Transverse	MAPKAPK5-AS1	0.16	0.09	lasso	13	0.06	7.1e-04	-5.3	-5.2	2.2e-07	-0.39	0.82	0.01	FALSE
25	GTEx	Colon Transverse	AC003029.1	0.15	0.09	lasso	12	0.07	2.1e-04	-5.3	-5.2	1.7e-07	-0.39	0.81	0.02	FALSE
26	GTEx	Esophagus Mucosa	ALDH2	0.05	0.06	lasso	6	0.07	1.7e-05	-5.3	5.7	1.1e-08	0.43	0.93	0.04	FALSE
27	GTEx	Esophagus Muscularis	HECTD4	0.06	0.03	lasso	4	0.02	1.8e-02	-5.3	5.9	3.5e-09	0.41	0.48	0.21	FALSE
28	GTEx	Esophagus Muscularis	MAPKAPK5-AS1	0.04	0.02	enet	7	0.02	2.7e-02	-5.3	-5.3	9.0e-08	-0.39	0.35	0.03	FALSE
29	GTEx	Nerve Tibial	ALDH2	0.05	0.04	lasso	3	0.05	2.4e-04	-5.3	5.4	8.1e-08	0.39	0.76	0.02	FALSE
30	GTEx	Nerve Tibial	HECTD4	0.05	0.01	enet	6	0.01	3.6e-02	-6.4	6.3	2.6e-10	0.41	0.19	0.53	FALSE
31	GTEx	Nerve Tibial	AC003029.1	0.04	0.00	lasso	23	0.00	4.2e-01	-4.4	-5.7	9.9e-09	-0.38	0.18	0.07	FALSE
32	GTEx	Pituitary	ADAM1A	0.18	0.22	enet	42	0.20	9.6e-06	-4.3	5.8	5.3e-09	0.35	0.81	0.02	FALSE
33	GTEx	Pituitary	RP3-462E2.5	0.15	0.12	lasso	3	0.14	2.3e-04	-5.2	6.4	1.2e-10	0.43	0.23	0.06	FALSE
34	GTEx	Skin Not Sun Exposed Suprapubic	ALDH2	0.13	0.18	lasso	9	0.16	5.0e-09	-5.3	5.7	9.3e-09	0.40	1.00	0.00	FALSE
35	GTEx	Skin Not Sun Exposed Suprapubic	MAPKAPK5-AS1	0.04	0.00	enet	30	0.00	7.0e-01	-5.3	-6.3	3.0e-10	-0.53	0.22	0.12	FALSE
36	GTEx	Skin Sun Exposed Lower leg	ALDH2	0.10	0.09	enet	13	0.13	6.7e-11	-5.3	7.4	1.3e-13	0.62	0.96	0.04	FALSE
37	GTEx	Skin Sun Exposed Lower leg	MAPKAPK5-AS1	0.09	0.10	lasso	4	0.10	1.1e-08	-5.3	-5.4	7.2e-08	-0.39	1.00	0.00	FALSE
38	GTEx	Skin Sun Exposed Lower leg	AC003029.1	0.09	0.10	lasso	2	0.10	8.8e-09	-5.3	-5.4	7.8e-08	-0.39	1.00	0.00	FALSE
39	GTEx	Stomach	TMEM116	0.13	0.03	lasso	7	0.03	1.6e-02	-4.4	-6.4	1.4e-10	-0.46	0.07	0.15	FALSE
40	GTEx	Testis	BRAP	0.06	0.03	enet	13	0.01	8.7e-02	-5.3	-5.9	4.5e-09	-0.41	0.44	0.07	FALSE
41	GTEx	Testis	MAPKAPK5-AS1	0.07	0.04	lasso	1	0.03	1.3e-02	-5.3	-5.3	1.1e-07	-0.38	0.18	0.16	FALSE
42	GTEx	Testis	AC003029.1	0.10	0.10	lasso	14	0.09	5.8e-05	-5.3	-5.4	6.9e-08	-0.38	0.62	0.14	FALSE
43	GTEx	Thyroid	BRAP	0.07	0.02	lasso	7	0.03	1.1e-03	-7.2	-6.9	5.3e-12	-0.54	0.27	0.57	FALSE
44	GTEx	Thyroid	ALDH2	0.06	0.04	lasso	4	0.05	9.7e-05	-7.2	7.5	9.2e-14	0.47	0.88	0.06	FALSE
45	GTEx	Thyroid	MAPKAPK5-AS1	0.04	0.04	lasso	2	0.03	1.5e-03	-5.3	-5.3	1.3e-07	-0.38	0.62	0.02	FALSE
46	GTEx	Thyroid	AC003029.1	0.04	0.05	lasso	3	0.04	8.3e-04	-5.3	-5.3	8.7e-08	-0.39	0.81	0.04	FALSE
47	NTR	Blood	ALDH2	0.06	0.01	blup	222	0.02	4.3e-08	-3.1	-5.7	1.5e-08	-0.43	0.99	0.00	FALSE
48	NTR	Blood	GIT2	0.02	0.01	lasso	11	0.01	1.8e-05	-4.5	-5.3	8.9e-08	-0.03	0.04	0.96	FALSE
49	YFS	Blood	SH2B3	0.05	0.01	enet	22	0.02	3.3e-07	-7.2	9.3	8.9e-21	0.64	0.52	0.48	TRUE
50	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C12orf47	0.07	0.04	lasso	2	0.03	1.0e-04	-5.2	-5.3	9.5e-08	-0.36	0.56	0.26	FALSE
51	The Cancer Genome Atlas	Brain Lower Grade Glioma	ACAD10	0.02	0.02	lasso	3	0.01	7.0e-03	-5.9	-5.9	2.8e-09	-0.50	0.02	0.75	FALSE
52	The Cancer Genome Atlas	Brain Lower Grade Glioma	ALDH2	0.03	0.03	lasso	1	0.03	3.1e-04	-5.3	5.3	1.4e-07	0.38	0.06	0.14	FALSE
53	The Cancer Genome Atlas	Brain Lower Grade Glioma	TMEM116	0.03	0.03	blup	43	0.03	8.0e-05	-4.4	-5.8	8.0e-09	-0.43	0.52	0.21	FALSE
54	The Cancer Genome Atlas	Brain Lower Grade Glioma	TRPV4	0.05	0.03	enet	15	0.04	2.1e-05	2.0	5.5	3.7e-08	0.12	0.05	0.60	TRUE
55	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	TMEM116	0.04	0.02	blup	43	0.02	3.5e-02	-4.3	-5.5	3.6e-08	-0.39	0.03	0.12	FALSE
56	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TMEM116	0.12	0.07	blup	43	0.10	7.6e-05	-4.4	-5.2	1.7e-07	-0.37	0.36	0.21	FALSE
57	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	ERP29	0.11	0.03	blup	25	0.05	5.0e-03	-5.3	-6.6	3.4e-11	-0.60	0.01	0.75	FALSE