TWAS hub - TRPV4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0794	0.0336	0.00170	0.009	0.002	0.02	0.016	0.012	0.01300	1.3e-01	4.9e-04	0.0016	0.00490
2	TCGA	Brain Lower Grade Glioma	0.0485	0.0213	0.00013	0.031	0.038	0.04	NA	0.030	0.00015	3.7e-05	2.1e-05	NA	0.00021

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Vitamin and mineral supplements	6.1	8.3	14.3	1.5	3.8
Systolic Blood Pressure	5.9	29.3	58.7	0.0	7.7
Blood Platelet Count	5.5	64.3	73.6	8.6	7.4
Systolic blood pressure, automated reading	5.3	15.4	30.4	-0.7	5.5
Medication: Lansoprazole	5.0	5.7	6.2	2.3	2.5
Diastolic blood pressure, automated reading	4.7	14.4	28.8	0.1	5.4
Chronic bronchitis/emphysema (mother)	4.5	5.2	8.1	2.8	1.6
Blood Eosinophil Count	4.2	32.3	50.0	3.8	7.1
Illnesses of siblings: Diabetes	4.0	5.0	7.3	1.6	2.7
Coronary Artery Disease (CAD)	3.9	4.7	9.3	0.1	3.1
Medication: Ibuprofen (e.g. Nurofen)	3.7	4.7	9.0	-0.6	-3.0
Seen a psychiatrist for nerves, anxiety, tension or depression	3.7	4.8	9.0	0.7	-3.0
Diabetes (mother)	3.5	4.4	5.4	2.3	1.9
Illnesses of siblings	3.5	4.9	7.7	-1.5	-2.8
Seen doctor (GP) for nerves, anxiety, tension or depression	3.5	5.4	10.7	-0.1	-3.3
Alcohol intake versus 10 years previously	3.4	5.1	10.0	-0.5	-3.2
Exposure to tobacco smoke at home	3.4	3.8	3.9	2.0	1.9
Fractured/broken bones in last 5 years	3.4	4.3	4.5	2.0	-2.1
Alcohol usually taken with meals	3.3	5.4	9.3	-1.2	-3.0
Had other major operations	3.3	4.1	4.4	2.1	-1.9
Number of full sisters	3.3	4.0	5.0	2.2	1.7
Multivitamins +/- minerals	3.1	3.9	7.1	-0.8	-2.7
Birth weight	3.1	6.8	13.5	0.3	-3.7
Neck or shoulder pain in last month	3.1	4.4	6.3	1.6	-2.5
Comparative height size at age 10	3.1	16.8	17.2	-4.0	-4.2
Ever depressed for a whole week	3.1	3.8	7.4	0.5	-2.7
Current tobacco smoking	3.0	4.9	9.9	3.1	-0.1
Medication: Seretide 50 evohaler	3.0	3.5	4.7	-1.5	-2.2
Ever had stillbirth, spontaneous miscarriage or termination	3.0	3.2	3.3	1.8	1.8
Hearing aid user	3.0	3.3	6.4	2.5	-0.5
Serious illness, injury or assault to yourself	2.9	3.5	3.5	1.9	-1.9
Heart disease (mother)	2.9	3.5	6.6	-0.7	2.6
Pulse rate, automated reading	2.9	9.4	16.0	1.7	4.0
Medication: Ibuprofen	2.8	3.4	6.3	0.7	-2.5
Relative age voice broke	2.7	4.2	7.8	0.7	2.8
Medication: Atenolol	2.6	3.3	6.2	0.6	2.5
Nervous feelings	2.6	4.9	6.0	1.9	2.4
Supplements: Vitamin C	2.6	3.1	5.9	-0.6	-2.4
Falls in the last year	2.5	3.4	4.1	1.6	-2.0
Pulse rate	2.5	4.1	7.5	0.9	2.7
Hearing difficulty/problems with background noise	2.4	3.8	7.4	0.5	2.7
Breastfed as a baby	2.4	3.0	6.0	0.2	-2.5
Medication for cholesterol, blood pressure or diabetes	2.4	3.9	6.8	1.0	-2.6
Smoking status: Current	2.3	3.6	7.2	2.7	0.0
High blood pressure	2.2	6.0	11.4	-0.8	3.4
Illnesses of mother	2.2	2.7	5.3	-0.3	-2.3
Ever taken oral contraceptive pill	2.2	2.4	4.8	2.2	0.2
Supplements: Calcium	2.2	2.5	4.4	2.1	-0.7
Arm fat-free mass (right)	2.1	10.6	17.9	-1.8	-4.2
Hypertension (Self-reported)	2.1	5.7	10.3	-1.1	3.2
Number of incorrect matches in round	2.0	3.4	5.0	-2.2	1.3
Medication: Ventolin 100micrograms inhaler	2.0	2.5	5.1	0.1	-2.3
Forced expiratory volume in 1-second (FEV1), predicted	2.0	4.2	4.2	-2.1	-2.0
Verbal and Numeric Reasoning (VNR)	1.9	4.7	6.7	-1.6	-2.6
Body Mass Index (BMI) (2010)	1.9	2.6	4.2	1.0	-2.1
Stomach or abdominal pain in last month	1.9	2.4	4.3	0.7	-2.1
Trunk fat-free mass	1.9	11.1	14.6	-2.8	-3.8
Trunk predicted mass	1.9	10.8	13.9	-2.8	-3.7
Medication: Blood pressure	1.9	3.4	6.0	-1.0	2.4
Leg fat-free mass (right)	1.9	9.9	16.2	-1.9	-4.0
Whole body water mass	1.9	10.7	15.9	-2.3	-4.0
Unable to work because of sickness or disability	1.9	2.5	4.4	2.1	-0.8
Depression (Nagel 2018)	1.8	2.7	5.4	-0.2	-2.3
Schizophrenia (2018)	1.8	3.7	6.6	-2.6	0.9
Triglycerides	1.8	3.0	5.6	0.6	2.4
Leg fat-free mass (left)	1.8	9.4	15.1	-2.0	-3.9
Leg predicted mass (left)	1.8	9.4	15.3	-1.9	-3.9
Impedance of arm (right)	1.8	8.3	16.4	-0.2	4.1
Headache pain in last month	1.8	3.0	5.6	-0.7	-2.4
Arm predicted mass (right)	1.8	9.4	16.4	-1.6	-4.0
Alcohol intake frequency.	1.8	4.2	6.3	-1.5	-2.5
Whole body fat-free mass	1.8	10.2	15.1	-2.3	-3.9
Leg predicted mass (right)	1.8	9.7	15.9	-1.9	-4.0
Age started oral contraceptive pill	1.8	2.3	4.4	2.1	-0.4
Pack years of smoking	1.8	2.6	3.9	-2.0	-1.2
Major Depression (MDD)	1.7	2.1	4.0	-0.4	-2.0
Mean Putamen Volume	1.7	2.0	3.8	-2.0	0.3
Length of working week for main job	1.7	1.8	3.1	0.7	1.8
Mouth/teeth dental problems: Bleeding gums	1.7	2.1	4.2	-0.3	2.0
High blood pressure (siblings)	1.7	2.5	4.3	0.8	2.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.7	2.0	2.4	-1.3	1.5
Medication: Paracetamol	1.7	2.6	4.3	2.1	0.9
Arm predicted mass (left)	1.7	8.9	14.9	-1.7	-3.9
Cardiovascular Disease	1.6	5.4	10.7	-0.2	3.3
Ever unenthusiastic/disinterested for a whole week	1.6	2.0	3.6	0.5	-1.9
Impedance of arm (left)	1.6	7.3	14.6	0.0	3.8
Number of children fathered	1.6	1.8	2.4	1.1	1.6
Basal metabolic rate	1.6	9.0	13.2	-2.2	-3.6
Arm fat-free mass (left)	1.6	8.3	13.2	-1.9	-3.6
Hypothyroidism (self reported)	1.5	3.4	6.4	-0.7	2.5
Sensitivity / hurt feelings	1.5	2.5	4.9	2.2	0.3
Supplements: Zinc	1.5	1.6	2.6	-0.8	-1.6
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	1.8	-1.3	-1.4
Number of live births	1.5	2.1	2.3	-1.4	1.5
Hypothyroidism/myxoedema (self-reported)	1.5	2.9	5.2	-0.8	2.3
Pulse wave peak to peak time	1.5	1.8	2.4	-1.6	1.1
Worry (Nagel 2018)	1.4	3.0	5.0	2.2	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.9	3.7	-0.1	-1.9
Hayfever/allergic rhinitis (self-reported)	1.4	1.9	2.1	-1.5	1.3
Prospective memory result	1.4	1.7	3.5	-1.9	-0.1
Blood clot in the leg (DVT)	1.4	1.8	3.5	1.9	0.2
Emphysema/chronic bronchitis	1.4	1.6	2.4	-0.9	-1.6
Chest pain or discomfort	1.4	2.1	4.1	0.1	-2.0
Commuting to job workplace: Cycle	1.4	1.7	3.1	-0.4	-1.8
Vascular/heart problems diagnosed by doctor	1.4	3.9	7.2	0.7	-2.7
Impedance of whole body	1.4	6.9	13.7	0.4	3.7
Frequency of depressed mood in last 2 weeks	1.3	1.8	3.6	0.1	-1.9
Medication for hormone replacement therapy	1.3	1.5	1.6	1.3	1.2
Hair/balding pattern: Pattern 2	1.3	1.7	2.9	-0.7	1.7
Standing height	1.3	13.1	15.6	-4.0	-3.2
Medication: Paracetamol	1.3	2.1	4.1	2.0	0.3
Medication: Omeprazole	1.3	1.5	2.8	1.7	0.5
Medication: Aspirin	1.3	1.7	3.2	-1.8	-0.5
Ever had bowel cancer screening	1.3	1.6	3.0	-1.7	-0.3
Back pain experienced in last month	1.3	1.9	3.8	1.9	-0.2
Miserableness	1.3	2.2	3.6	1.9	-0.9
Waist Hip Ratio (WHR)	1.2	5.3	6.6	2.0	2.6
Severe depression (siblings)	1.2	1.3	2.1	-0.7	-1.5
Impedance of leg (right)	1.2	5.6	10.8	0.7	3.3
Had menopause	1.2	1.5	2.5	1.6	0.6
Qualifications: None of the above	1.2	2.6	4.9	-2.2	-0.5
Pulse wave Arterial Stiffness index	1.2	1.4	1.7	1.0	-1.3
Wears glasses or contact lenses	1.2	1.3	2.7	0.1	-1.6
Risk taking	1.2	1.8	2.5	1.6	-1.1
Bipolar Disorder or Schizophrenia	1.1	2.6	5.1	-2.3	-0.2
Alzheimer’s Disease (in mother)	1.1	1.3	2.5	-0.3	1.6
Schizophrenia (2014)	1.1	2.5	4.4	-2.1	0.7
Hearing difficulty/problems: Yes	1.1	1.6	2.0	1.4	1.1
Medication: Co-codamol	1.1	1.2	2.2	1.5	-0.5
Pack years adult smoking proportion	1.1	1.8	2.3	-1.5	-1.1
Neuroticism score	1.1	2.3	4.5	2.1	-0.3
Eye problems/disorders: Glaucoma	1.1	1.3	1.7	-1.3	-1.0
Illnesses of father: High blood pressure	1.1	1.4	1.6	1.1	1.3
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	2.2	1.5	0.7
Neuroticism (2016)	1.0	1.5	2.2	1.5	0.9
Height	1.0	19.7	27.8	-5.3	-3.4
Fed-up feelings	1.0	1.8	3.0	1.7	-0.8
Taking other prescription medications	1.0	1.6	1.9	-1.1	-1.4
Sitting height	1.0	7.0	7.7	-2.8	-2.5
Impedance of leg (left)	1.0	5.0	9.8	0.5	3.1
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	2.4	0.8	-1.6
Forced expiratory volume in 1-second (FEV1)	1.0	3.3	6.1	-0.8	-2.5
Depression (self-reported)	1.0	1.2	2.2	0.5	-1.5
Number of full brothers	1.0	1.2	2.1	-0.6	-1.4
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	1.5	0.9	1.2
Mineral and other dietary supplements	1.0	1.4	2.5	-0.5	1.6
Medication: Aspirin	1.0	1.3	2.5	-1.6	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.0	3.9	-0.4	-2.0
Deep venous thrombosis (DVT) (self-reported)	1.0	1.2	2.4	1.6	-0.3
Alcohol drinker status: Previous	1.0	1.1	1.6	-0.8	-1.3
Reaction Time	0.9	1.8	3.5	0.4	1.9
Forced vital capacity (FVC)	0.9	3.6	5.2	-1.4	-2.3
Medication: Ramipril	0.9	1.2	2.1	-1.4	-0.6
Weight	0.9	4.3	5.9	-1.6	-2.4
Hair/balding pattern: Pattern 3	0.9	1.3	2.6	-1.6	-0.1
Medication: Allopurinol	0.9	1.3	2.4	-0.4	1.5
Illnesses of father: None of the above (group 1)	0.9	1.1	1.9	-0.5	-1.4
Number of self-reported non-cancer illnesses	0.9	1.6	1.7	-1.2	1.3
Financial situation satisfaction	0.9	1.1	1.9	-1.4	0.5
Intelligence (Savage-Jansen 2018)	0.8	2.5	2.7	-1.6	-1.5
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	1.5	1.2	-0.6
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	1.2	-0.7	1.1
Medication: Levothyroxine sodium	0.8	1.4	2.5	-0.6	1.6
Pain all over the body in last month	0.8	0.9	1.1	0.8	1.0
Medication: Simvastatin	0.8	1.2	2.2	0.6	1.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.6	4.8	-0.6	-2.2
Birth weight of first child	0.8	1.5	1.7	-1.3	-1.1
Pulse wave reflection index	0.8	1.0	1.4	0.8	-1.2
Ever highly irritable/argumentative for 2 days	0.8	0.9	1.8	1.3	0.1
Glaucoma (self-reported)	0.8	0.9	1.1	-1.0	-0.8
Gout (self-reported)	0.8	1.1	1.8	-0.7	1.3
Worry too long after embarrassment	0.8	1.3	2.6	1.6	0.1
Age at first live birth	0.8	1.4	2.7	0.3	-1.6
Smoking status: Previous	0.8	1.2	1.2	-1.1	1.1
Handedness (chirality/laterality): Left-handed	0.8	0.9	1.6	-0.5	1.3
Loneliness, isolation	0.8	1.1	1.8	0.7	-1.4
Guilty feelings	0.8	1.2	2.2	0.5	-1.5
High cholesterol (Self-reported)	0.8	1.4	1.7	-1.1	1.3
Irritability	0.8	1.4	2.6	1.6	0.4
Bipolar Disorder (2018)	0.7	1.2	1.9	-0.6	-1.4
Depressed Affect (Nagel 2018)	0.7	1.5	2.7	0.6	-1.6
Alzheimer’s Disease (in father)	0.7	0.8	1.1	-0.7	-1.0
Lupus	0.7	1.0	2.0	0.3	1.4
Lung FVC	0.7	3.6	5.2	1.4	-2.3
Diabetes (father)	0.7	0.8	1.0	-1.0	0.8
Time employed in main current job	0.7	0.9	1.4	-1.2	-0.5
Worrier / anxious feelings	0.7	1.3	1.8	1.3	-0.8
Happiness	0.7	0.9	1.7	0.0	-1.3
Qualifications: A levels/AS levels or equivalent	0.7	1.5	2.0	-1.4	-1.0
Lung cancer (father)	0.7	0.8	1.7	-1.3	0.2
Migraine (self-reported)	0.7	0.8	0.9	0.8	1.0
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	1.2	-1.1	-0.7
Neuroticism (Nagel 2018)	0.6	1.4	2.5	1.6	-0.4
Schizophrenia vs Biploar Disorder	0.6	0.8	1.6	-0.2	1.3
Crohns Disease (2017)	0.6	1.2	2.4	1.5	-0.2
Primary Biliary Cirrhosis	0.6	0.9	1.7	-0.1	-1.3
Rheumatoid Arthritis	0.6	0.8	1.6	0.1	1.2
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.4	-1.2	-0.2
Blood Red Count	0.6	6.2	10.5	1.4	3.2
Blood White Count	0.6	4.4	5.4	2.3	1.8
Respiratory disease	0.6	1.4	1.5	-1.1	-1.2
Neuroticism	0.6	1.4	2.8	1.7	-0.4
Tanning	0.6	7.8	12.1	3.5	1.9
Relative age of first facial hair	0.6	1.3	1.4	1.2	1.1
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.3	1.1	0.5
Medication: Metformin	0.6	0.9	1.0	1.0	0.9
Chronic bronchitis/emphysema (father)	0.6	0.7	1.1	-1.1	-0.6
Asthma	0.6	1.1	2.1	-0.4	-1.4
Medication: Cholesterol lowering	0.6	1.0	1.2	-0.8	1.1
Medication: Amlodipine	0.6	0.8	1.7	-0.1	1.3
Forced vital capacity (FVC), Best measure	0.6	2.4	2.8	-1.4	-1.7
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	1.9	0.1	-1.4
Medication: Atorvastatin	0.6	0.7	1.1	-1.1	-0.6
Average weekly beer plus cider intake	0.6	0.9	1.5	1.2	0.6
Cholesterol lowering medication	0.6	0.8	1.2	1.1	0.7
Basal cell carcinoma (self-reported)	0.6	0.7	1.0	-0.7	-1.0
Leg fat mass (left)	0.6	2.5	4.5	-0.7	-2.1
Alzheimer’s Disease (including proxy)	0.5	0.7	1.4	-0.2	1.2
Crohns Disease (2012)	0.5	0.7	1.5	1.2	-0.1
BMI	0.5	2.6	4.8	0.7	-2.2
Lung FEV1/FVC ratio	0.5	2.6	5.2	0.2	-2.3
Number of treatments/medications taken	0.5	1.0	1.7	-0.5	-1.3
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.9	1.4	0.5	-1.2
Financial difficulties in last 2 years	0.5	0.7	0.7	-0.8	0.8
Fluid intelligence score	0.5	1.0	1.5	-0.7	-1.2
Peak expiratory flow (PEF)	0.5	1.1	2.2	0.1	-1.5
Mouth/teeth dental problems: Loose teeth	0.5	0.5	1.0	-0.2	1.0
Angina (self-reported)	0.5	0.7	0.7	0.8	-0.9
Mean time to correctly identify matches	0.5	1.0	2.0	-0.1	1.4
Leg fat mass (right)	0.5	2.0	3.8	-0.5	-1.9
Illnesses of father: Heart disease	0.5	0.7	1.3	0.2	1.2
Average weekly red wine intake	0.5	0.8	1.3	1.1	-0.6
Diabetes diagnosed by doctor	0.5	0.9	1.7	-0.3	1.3
Qualifications: nursing, teaching	0.5	0.8	1.2	1.1	-0.6
Medication for cholesterol	0.5	0.7	1.2	-1.1	-0.5
Asthma (self-reported)	0.5	1.1	1.9	-0.5	-1.4
Medication: Blood pressure	0.5	0.9	1.7	0.3	1.3
Supplements: Fish oil (including cod liver oil)	0.5	0.6	0.9	-0.6	-0.9
Age at First Birth	0.4	0.5	1.0	-0.2	1.0
Heel T-Score	0.4	3.2	6.2	-2.5	-0.5
Smoking Status	0.4	1.0	1.4	1.2	0.8
Type 2 Diabetes (T2D) (2018)	0.4	0.8	1.6	0.1	1.3
Hand grip strength (left)	0.4	0.9	1.2	-1.1	-0.8
Angina	0.4	0.6	1.0	0.4	-1.0
Supplements: Glucosamine	0.4	0.5	1.0	1.0	0.1
High blood pressure (mother)	0.4	0.6	1.2	0.1	1.1
Hip circumference	0.4	1.7	2.9	-0.7	-1.7
Noisy workplace	0.4	0.4	0.5	0.7	-0.7
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	0.6	0.6	0.8
Health satisfaction	0.4	0.6	0.7	-0.8	-0.7
Medication for pain relief, constipation, heartburn	0.4	0.6	1.1	-0.4	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	0.9	0.4	-0.9
Pain type(s) experienced in last month: Hip pain	0.4	0.5	0.7	-0.8	0.6
Alcohol drinker status: Never	0.4	0.5	0.5	0.7	-0.7
Number of operations (self-reported)	0.4	0.7	1.0	1.0	-0.6
Ever had prostate specific antigen (PSA) test	0.4	0.5	0.6	-0.6	0.8
Heart attack/myocardial infarction (self-reported)	0.4	0.6	1.1	-1.1	-0.0
Heart disease (siblings)	0.4	0.5	0.9	1.0	0.0
Chronotype (morning person)	0.3	0.7	1.1	1.0	0.5
Trunk fat mass	0.3	1.2	1.6	-1.3	-0.9
Past tobacco smoking	0.3	0.5	0.8	0.4	-0.9
Heart attack	0.3	0.4	0.8	-0.9	-0.1
Diabetes (self-reported)	0.3	0.4	0.6	-0.4	0.8
Mouth/teeth dental problems: Dentures	0.3	0.5	0.9	0.9	0.3
Hair/balding pattern: Pattern 4	0.3	0.8	0.8	-0.9	-0.9
Eye problems/disorders: None of the above	0.3	0.3	0.4	-0.6	-0.6
Whole body fat mass	0.3	1.3	1.4	-1.1	-1.2
Suffer from ‘nerves’	0.3	0.4	0.6	0.8	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	0.7	0.8	0.3
Friendships satisfaction	0.3	0.3	0.6	-0.7	-0.4
Medication: Gliclazide	0.3	0.3	0.6	0.3	0.8
Average weekly champagne plus white wine intake	0.3	0.4	0.5	0.7	0.6
Myopia	0.3	0.5	0.8	-0.9	0.2
Irritable Bowel Disease (IBD)	0.2	0.5	0.8	0.9	0.4
Fasting Glucose	0.2	0.3	0.4	-0.4	-0.6
LDL Cholesterol	0.2	0.3	0.4	0.4	0.7
Ulcerative Colitis	0.2	0.2	0.2	0.5	0.5
Ever had hysterectomy (womb removed)	0.2	0.2	0.3	-0.6	0.3
Hand grip strength (right)	0.2	0.7	1.3	-1.1	0.3
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.5	0.3	0.7
Body mass index (BMI)	0.2	0.7	1.4	0.2	-1.2
Father’s age at death	0.2	0.3	0.6	0.8	-0.1
Arm fat mass (right)	0.2	0.8	1.1	-0.7	-1.0
Tense / ‘highly strung’	0.2	0.4	0.7	0.9	0.2
Loud music exposure frequency	0.2	0.2	0.4	0.6	0.3
Comparative body size at age 10	0.2	0.5	0.6	0.8	-0.7
Wheeze or whistling in the chest in last year	0.2	0.4	0.8	0.2	-0.9
Qualifications: College or University degree	0.2	0.7	0.8	-0.7	-0.9
Had major operations	0.2	0.3	0.5	-0.7	-0.0
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.4	-0.6	-0.1
Knee pain experienced in last month	0.2	0.3	0.4	0.7	-0.4
Mood swings	0.2	0.4	0.8	0.9	-0.0
Long-standing illness, disability or infirmity	0.2	0.2	0.3	0.3	-0.6
Eye problems/disorders: Cataract	0.2	0.2	0.3	0.6	0.2
Osteoporosis (self-reported)	0.2	0.3	0.5	0.3	-0.7
Arm fat mass (left)	0.2	0.7	1.1	-0.6	-1.0
Mother’s age at death	0.2	0.3	0.5	0.1	-0.7
Commuting to job workplace: Public transport	0.2	0.2	0.3	0.6	-0.2
Medication: Lisinopril	0.2	0.2	0.5	0.0	0.7
Ever smoked	0.2	0.3	0.6	0.8	-0.1
Ulcerative Colitis (UC)	0.1	0.2	0.4	-0.1	0.6
HbA1C	0.1	0.2	0.3	-0.6	0.1
Average weekly spirits intake	0.1	0.1	0.3	0.5	-0.1
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.1	0.3	-0.3
Trunk fat percentage	0.1	0.2	0.3	-0.4	0.6
Townsend deprivation index at recruitment	0.1	0.2	0.3	-0.2	-0.5
Maternal smoking around birth	0.1	0.1	0.2	0.4	0.3
Qualifications: CSEs or equivalent	0.1	0.1	0.1	0.2	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.3	0.5	0.5
Allergy	0.1	0.3	0.3	-0.6	0.5
Arm fat percentage (right)	0.1	0.3	0.6	-0.3	0.7
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.1	0.4	0.2
Exposure to tobacco smoke outside home	0.1	0.1	0.1	-0.3	-0.3
Shortness of breath walking on level ground	0.1	0.1	0.2	0.4	0.0
Overall health rating	0.1	0.2	0.4	-0.2	-0.6
Age at last live birth	0.1	0.2	0.3	-0.2	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.3	-0.5	-0.0
Osteoarthritis (self-reported)	0.1	0.1	0.1	-0.3	0.3
Tinnitus: Yes, now most or all of the time	0.1	0.2	0.3	0.2	-0.5
Medication: Bendroflumethiazide	0.1	0.1	0.1	-0.3	0.3
Pain experienced in last month	0.1	0.2	0.4	-0.3	-0.6
Breast Cancer	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	0.0	0.0	0.0	-0.0	-0.2
Prostate Cancer	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
HDL Cholesterol	0.0	0.0	0.1	0.1	-0.3
Allergy or Eczema	0.0	0.0	0.0	0.1	0.1
Hair Pigment	0.0	0.2	0.4	0.6	0.3
Average weekly fortified wine intake	0.0	0.0	0.0	-0.0	-0.0
Age when periods started (menarche)	0.0	0.0	0.1	-0.2	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.1	0.1	0.3	-0.3
Hayfever, allergic rhinitis or eczema	0.0	0.0	0.0	0.2	0.1
Waist circumference	0.0	0.2	0.3	-0.1	-0.6
Mouth/teeth dental problems	0.0	0.1	0.1	0.3	-0.3
Body fat percentage	0.0	0.1	0.2	-0.3	0.5
Leg fat percentage (right)	0.0	0.2	0.3	0.6	0.1
Family relationship satisfaction	0.0	0.0	0.0	-0.1	0.1
Leg pain on walking	0.0	0.1	0.1	-0.3	-0.0
Arm fat percentage (left)	0.0	0.1	0.2	-0.2	0.5
Commuting to job workplace: Walk	0.0	0.0	0.1	-0.2	0.1
Breast cancer (self-reported)	0.0	0.0	0.0	-0.2	0.2
Leg fat percentage (left)	0.0	0.0	0.1	0.3	-0.1

Hub : Genes

TRPV4

Models

Trait associations