TWAS hub - ACHE

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.3510	0.0570	4.8e-15	0.311	NA	0.324	NA	0.319	1.3e-17	NA	1.9e-18	NA	3.7e-18
2	GTEx	Artery Tibial	0.0980	0.0365	1.6e-03	0.088	NA	0.068	NA	0.079	2.0e-07	NA	5.1e-06	NA	9.2e-07
3	GTEx	Esophagus Mucosa	0.0830	0.0320	7.9e-04	0.033	NA	0.018	NA	0.035	2.8e-03	NA	2.1e-02	NA	2.2e-03
4	GTEx	Heart Atrial Appendage	0.1880	0.0610	3.1e-04	0.192	NA	0.126	NA	0.175	5.4e-09	NA	2.9e-06	NA	2.6e-08
5	GTEx	Nerve Tibial	0.2777	0.0578	6.2e-10	0.233	NA	0.205	NA	0.225	1.8e-16	NA	1.6e-14	NA	6.1e-16
6	GTEx	Skin Sun Exposed Lower leg	0.0740	0.0320	2.7e-03	0.102	NA	0.056	NA	0.094	8.6e-09	NA	2.0e-05	NA	3.5e-08
7	GTEx	Thyroid	0.1920	0.0490	9.2e-08	0.101	NA	0.136	NA	0.094	3.8e-08	NA	1.5e-10	NA	1.1e-07
8	GTEx	Whole Blood	0.0770	0.0320	3.0e-03	0.000	NA	0.017	NA	0.010	2.8e-01	NA	9.2e-03	NA	4.0e-02
9	TCGA	Breast Invasive Carcinoma	0.0259	0.0157	3.2e-03	0.010	0.011	0.009	NA	0.009	3.6e-03	0.00180	5.3e-03	NA	4.3e-03
10	TCGA	Thyroid Carcinoma	0.0390	0.0220	2.6e-03	0.041	0.031	0.029	NA	0.033	6.7e-05	0.00048	7.1e-04	NA	3.0e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Pulse rate, automated reading	88.8	287.0	342.2	18.4	18.4	17.2	18.4	18.1	18.2	16.2	9.5	14.3	18.5
Pulse rate	53.5	90.3	112.4	10.2	10.5	9.4	10.5	10.6	10.4	8.4	5.2	8.1	10.3
Diastolic blood pressure, automated reading	14.9	46.2	52.8	7.3	7.0	7.0	6.9	7.2	7.0	6.4	5.9	6.1	7.0
Average weekly fortified wine intake	6.7	7.9	10.9	-3.3	-2.8	-3.2	-3.0	-2.8	-2.9	-2.7	-2.5	-1.7	-2.8
Hand grip strength (right)	6.2	17.0	21.9	3.9	4.7	3.0	4.7	4.4	4.7	4.4	0.9	4.5	4.5
Hair/balding pattern: Pattern 3	6.0	9.0	13.0	-3.3	-3.1	-3.3	-3.1	-2.8	-3.0	-3.6	-2.2	-2.4	-2.9
Hypothyroidism/myxoedema (self-reported)	6.0	11.7	15.5	-3.4	-3.5	-3.7	-3.9	-3.8	-3.8	-2.5	-1.4	-3.8	-3.5
Stomach or abdominal pain in last month	5.9	7.4	11.0	-2.7	-2.7	-3.3	-2.8	-2.6	-2.6	-2.9	-1.6	-2.6	-2.9
Medication: Atorvastatin	5.6	7.0	9.0	3.0	2.6	2.6	2.7	2.5	2.7	2.8	1.7	2.6	2.8
Hand grip strength (left)	5.3	14.1	17.8	3.5	4.2	2.9	4.2	4.1	4.2	4.2	1.1	4.0	3.9
Fasting Glucose	5.2	6.2	9.3	-2.5	-2.8	-1.0	-2.9	-2.8	-2.9	-2.5	-1.1	-2.3	-3.0
Type 2 Diabetes (T2D) (2018)	5.0	9.3	13.3	-3.0	-3.2	-3.4	-3.2	-3.1	-3.0	-3.0	-1.2	-3.6	-3.1
Supplements: Glucosamine	5.0	6.5	10.1	-2.4	-2.6	-2.6	-3.2	-3.0	-3.1	-2.0	-0.4	-2.4	-2.6
Forced vital capacity (FVC), Best measure	4.5	16.4	20.8	4.6	4.5	4.3	4.4	4.2	4.3	4.4	1.3	3.6	3.8
Forced vital capacity (FVC)	4.4	17.0	20.7	4.5	4.5	4.3	4.5	4.5	4.5	4.6	1.4	3.5	3.9
Irritable Bowel Disease (IBD)	4.2	9.9	15.1	3.7	3.6	2.8	3.9	3.8	3.9	2.2	0.9	0.5	3.8
Medication: Metformin	4.2	5.9	16.4	-1.9	-2.9	-1.6	-2.5	-2.6	-2.4	-1.6	-0.4	-4.1	-2.5
Ever smoked	4.2	7.4	10.4	-2.8	-3.2	-2.2	-3.2	-3.2	-3.2	-2.1	-0.6	-2.4	-3.1
Heel T-Score	4.1	32.9	57.3	-7.4	-5.0	-7.6	-5.3	-4.9	-5.1	-5.9	-5.5	-4.8	-5.1
Past tobacco smoking	4.1	7.5	10.6	2.7	3.2	2.2	3.2	3.1	3.1	2.5	-0.6	2.4	3.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	4.1	4.8	6.5	2.4	2.5	2.5	2.4	2.5	2.4	1.3	0.6	2.0	2.5
Supplements: Zinc	3.9	4.2	6.4	-2.1	-2.1	-2.5	-2.2	-2.2	-2.1	-1.6	-1.6	-2.1	-1.8
Smoking status: Previous	3.9	5.8	8.2	-2.4	-2.8	-2.0	-2.9	-2.6	-2.8	-2.1	0.9	-2.0	-2.8
Hypothyroidism (self reported)	3.8	8.8	13.2	-2.9	-3.1	-3.4	-3.6	-3.4	-3.6	-1.4	-0.8	-3.0	-3.1
Heart disease (siblings)	3.8	4.7	6.9	2.5	2.1	2.6	2.1	2.2	2.1	2.2	2.1	1.4	2.0
Long-standing illness, disability or infirmity	3.7	5.6	8.2	-2.3	-2.3	-2.7	-2.8	-2.4	-2.7	-1.9	-0.5	-2.9	-2.3
Medication: Levothyroxine sodium	3.6	6.0	8.4	-2.6	-2.3	-2.9	-2.8	-2.7	-2.7	-1.6	-0.9	-2.8	-2.5
LDL Cholesterol	3.4	5.3	7.8	2.0	2.4	2.3	2.8	2.7	2.7	2.1	1.1	2.2	2.4
Diabetes (father)	3.3	4.1	5.2	-2.2	-2.0	-2.2	-2.0	-2.0	-2.0	-2.0	-1.3	-1.9	-2.3
Mineral and other dietary supplements	3.3	4.4	7.6	1.8	2.4	1.5	2.7	2.7	2.8	0.8	0.2	2.1	2.2
HDL Cholesterol	3.2	5.3	9.0	2.2	2.3	3.0	2.2	2.3	2.2	2.4	1.9	2.2	2.1
Schizophrenia (2014)	3.2	7.1	11.8	2.7	2.9	2.6	3.4	3.4	3.4	1.1	1.8	0.7	2.8
Other serious medical condition/disability diagnosed by doctor	3.1	4.1	6.2	-2.1	-2.1	-2.1	-2.2	-2.1	-2.2	-1.6	-0.1	-2.5	-2.2
Father’s age at death	3.1	4.2	6.5	-2.1	-2.5	-0.9	-2.4	-2.4	-2.5	-1.6	0.5	-2.2	-2.3
Diabetes diagnosed by doctor	3.1	5.1	10.5	-2.1	-2.6	-2.4	-2.4	-2.4	-2.3	-1.2	-0.9	-3.2	-2.2
Ulcerative Colitis	3.0	4.4	6.5	2.5	2.1	2.0	2.5	2.5	2.6	1.9	1.2	-0.5	2.1
Diabetes (self-reported)	3.0	4.7	8.2	-2.0	-2.2	-2.9	-2.0	-2.0	-1.9	-1.6	-2.0	-2.7	-1.9
Ever had stillbirth, spontaneous miscarriage or termination	3.0	3.2	6.5	-1.8	-1.6	-2.5	-1.7	-1.5	-1.5	-2.4	-1.3	-1.8	-1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.0	6.3	9.3	3.0	2.7	2.6	2.8	2.7	2.7	2.3	1.9	1.8	2.3
Medication: Omeprazole (e.g. Zanprol)	3.0	3.6	5.6	-2.1	-2.1	-2.3	-2.1	-2.0	-2.1	-1.3	-0.6	-1.1	-2.4
Bipolar Disorder or Schizophrenia	2.9	7.2	12.7	2.5	3.2	1.9	3.5	3.5	3.6	1.8	0.9	0.7	3.2
Ulcerative Colitis (UC)	2.9	5.4	8.6	2.8	2.2	2.9	2.6	2.5	2.6	2.6	0.9	-0.4	2.3
Height	2.9	56.1	81.9	7.5	8.1	7.2	7.6	7.4	7.6	9.1	2.8	8.4	7.5
Medication: Omeprazole	2.9	3.4	5.9	-2.0	-2.0	-2.4	-1.9	-1.7	-1.8	-1.6	-0.8	-1.4	-2.2
Deep venous thrombosis (DVT) (self-reported)	2.9	3.7	6.0	-1.2	-2.0	-1.2	-2.2	-2.1	-2.1	-2.4	-1.1	-2.4	-1.9
Crohns Disease (2017)	2.8	6.2	10.1	2.8	3.0	1.6	3.2	3.2	3.2	0.7	0.9	0.7	3.2
Medication: Seretide 50 evohaler	2.8	3.2	5.5	2.3	1.8	1.5	1.9	1.9	1.9	1.4	1.9	1.2	2.0
Blood Red Count	2.6	24.8	102.0	-1.7	4.4	-5.4	2.9	5.7	4.6	-10.1	-3.4	0.4	4.5
Hair Pigment	2.6	73.8	121.0	-7.6	-10.7	-2.0	-10.6	-10.7	-10.7	-5.6	1.8	-8.1	-11.0
Serious illness, injury or assault of a close relative in last 2 years	2.6	3.0	7.2	-1.7	-1.4	-2.5	-1.4	-1.4	-1.4	-2.0	-2.7	-0.8	-1.0
Medication: Gliclazide	2.6	2.9	7.9	-1.6	-1.6	-2.0	-1.7	-1.6	-1.6	-1.3	-0.6	-2.8	-1.6
Schizophrenia (2018)	2.5	5.2	9.7	2.2	2.7	1.8	3.0	3.0	3.1	0.6	1.1	1.0	2.5
Average weekly red wine intake	2.5	3.7	5.9	-2.1	-2.2	-0.8	-2.1	-2.1	-2.1	-1.6	0.9	-2.1	-2.4
Supplements: Fish oil (including cod liver oil)	2.5	3.2	6.3	-1.3	-2.2	-0.6	-2.2	-2.2	-2.3	-0.7	-0.4	-2.5	-1.9
Cholesterol lowering medication	2.5	3.7	6.5	1.9	1.8	2.1	1.9	2.0	1.9	2.5	1.8	0.7	2.1
Townsend deprivation index at recruitment	2.4	3.3	6.0	1.1	2.0	0.1	2.1	2.0	2.1	0.7	-2.4	2.4	1.7
Blood clot in the leg (DVT)	2.4	3.1	4.6	-1.1	-1.8	-1.1	-2.0	-2.0	-2.0	-2.1	-1.0	-2.1	-1.8
Age at first live birth	2.4	4.3	7.5	-2.3	-2.4	-1.8	-2.5	-2.4	-2.6	-0.9	-0.3	-1.4	-2.7
Mean time to correctly identify matches	2.4	4.6	7.8	2.0	2.5	1.6	2.3	2.4	2.4	2.8	1.2	0.7	2.5
Suffer from ‘nerves’	2.4	3.8	5.7	2.1	2.2	1.7	2.3	2.2	2.3	1.5	0.8	1.4	2.4
Standing height	2.3	22.8	31.8	4.9	5.3	5.0	4.8	4.8	4.9	5.6	1.2	5.0	4.8
Pulse wave reflection index	2.3	2.9	5.3	-2.0	-1.5	-1.9	-1.6	-1.6	-1.6	-2.3	-1.4	-1.4	-1.4
Number of operations (self-reported)	2.2	3.3	9.2	-1.7	-1.0	-2.1	-1.3	-0.9	-1.1	-3.0	-2.9	-1.9	-0.7
Lung FEV1/FVC ratio	2.1	10.7	14.7	-3.8	-3.8	-2.2	-3.4	-3.5	-3.5	-3.8	0.7	-3.1	-3.4
Pack years adult smoking proportion	2.1	3.2	7.5	-2.3	-1.4	-2.7	-1.4	-1.2	-1.4	-1.9	-2.4	-0.8	-1.1
Heart attack	2.1	2.7	5.0	-1.6	-1.6	-2.0	-1.8	-1.5	-1.7	-2.2	-1.2	-1.0	-1.4
Illnesses of siblings	2.1	3.0	6.7	-1.9	-1.5	-2.6	-1.6	-1.6	-1.5	-2.0	-2.0	-0.6	-1.3
Alzheimer’s Disease (in father)	2.0	2.2	4.1	-1.5	-1.3	-2.0	-1.2	-1.4	-1.2	-1.8	-1.3	-1.3	-1.5
Crohns Disease (2012)	2.0	3.2	6.5	1.2	2.3	-0.3	2.4	2.5	2.5	-0.1	-0.5	0.7	2.4
Sensitivity / hurt feelings	2.0	3.5	5.3	-2.3	-2.1	-1.4	-2.1	-2.2	-2.1	-1.4	-1.2	-1.3	-2.2
Medication: Ibuprofen (e.g. Nurofen)	2.0	2.6	5.3	-1.9	-1.3	-2.3	-1.3	-1.3	-1.2	-2.1	-2.0	-1.0	-1.0
Forced expiratory volume in 1-second (FEV1), Best measure	2.0	6.3	8.7	2.8	2.8	3.0	2.7	2.6	2.6	2.7	0.8	2.1	2.3
Medication: Ibuprofen	2.0	2.4	5.6	-1.8	-1.0	-2.4	-1.1	-1.1	-1.1	-2.1	-2.2	-0.8	-0.8
Lupus	1.9	2.8	5.2	-1.5	-1.7	-1.2	-1.8	-1.7	-1.8	-2.1	0.9	-2.3	-1.2
Lung FVC	1.9	9.7	15.6	3.2	3.2	3.4	3.4	3.2	3.2	4.0	1.3	2.6	2.9
Hair/balding pattern: Pattern 2	1.9	2.4	5.7	1.9	0.9	2.1	1.1	0.9	1.0	2.3	2.4	0.1	1.1
Pulse wave Arterial Stiffness index	1.9	2.2	4.7	1.2	1.9	0.5	1.6	1.7	1.7	0.1	-0.6	1.8	2.2
Medication: Aspirin	1.9	2.5	4.5	-1.2	-2.1	-0.7	-1.9	-2.1	-1.9	-0.5	-0.8	-1.8	-1.8
Age at First Birth	1.8	2.6	4.7	-1.9	-1.8	-0.8	-2.0	-2.2	-2.1	-0.6	-1.0	-1.2	-1.8
Had other major operations	1.8	2.2	4.9	-1.4	-1.4	-1.3	-1.2	-1.1	-1.1	-2.2	-1.6	-1.7	-1.4
Forced expiratory volume in 1-second (FEV1)	1.8	6.0	8.5	2.6	2.6	2.9	2.7	2.6	2.6	2.7	1.0	1.9	2.1
Mood swings	1.8	3.2	6.3	-2.1	-1.3	-2.5	-1.6	-1.6	-1.6	-1.4	-2.4	-1.4	-1.6
Fluid intelligence score	1.7	3.5	5.5	1.9	2.1	0.9	2.3	2.2	2.3	1.5	0.7	2.0	2.0
Heart attack/myocardial infarction (self-reported)	1.7	2.3	4.2	-1.4	-1.4	-1.9	-1.6	-1.4	-1.6	-2.1	-1.2	-0.8	-1.3
Reaction Time	1.6	3.1	5.7	1.6	2.2	1.0	2.0	2.1	2.0	2.4	0.6	0.5	1.9
Birth weight	1.6	3.4	8.9	1.3	1.7	2.0	1.7	1.6	1.7	3.0	-1.1	1.7	1.9
Pack years of smoking	1.6	2.4	5.0	-2.1	-1.3	-2.2	-1.3	-1.2	-1.3	-1.4	-2.2	-0.7	-1.0
Bipolar Disorder (2018)	1.5	2.3	4.1	1.2	1.8	0.8	1.8	1.9	1.8	2.0	0.1	-0.2	2.0
Medication: Aspirin	1.5	1.9	3.2	-1.0	-1.8	-0.4	-1.7	-1.8	-1.6	-0.5	-0.5	-1.8	-1.5
Number of children fathered	1.4	1.5	2.2	-0.6	-1.3	-1.4	-1.5	-1.2	-1.4	-1.1	0.6	-1.4	-1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.6	2.7	-0.9	-1.6	-1.6	-1.3	-1.3	-1.3	-1.4	-0.1	-1.1	-1.5
Mother’s age at death	1.4	1.8	3.9	-1.7	-1.0	-2.0	-1.2	-1.0	-1.1	-1.5	-1.6	-0.8	-1.0
Mean Putamen Volume	1.3	1.5	3.8	-1.7	-1.2	-2.0	-1.0	-1.2	-0.9	-0.7	-1.3	-0.3	-1.1
Trunk fat mass	1.3	5.5	8.3	2.4	2.6	2.1	2.4	2.7	2.5	1.6	2.9	1.5	2.3
Had menopause	1.3	1.6	3.1	1.2	1.4	1.3	1.4	1.2	1.3	1.8	0.2	0.5	1.5
Pulse wave peak to peak time	1.3	1.6	3.6	-1.0	-1.6	-0.2	-1.4	-1.5	-1.4	0.0	0.5	-1.4	-1.9
Health satisfaction	1.3	1.7	2.9	-1.3	-1.5	-0.9	-1.3	-1.3	-1.2	-1.1	0.7	-1.7	-1.6
Breast Cancer	1.2	2.8	7.1	-2.5	-1.2	-2.7	-1.5	-1.1	-1.4	-1.0	-2.1	-0.5	-1.5
Diabetes (mother)	1.2	1.5	3.2	-1.3	-1.3	-0.2	-1.2	-1.1	-1.2	-1.8	-0.5	-1.5	-1.4
Impedance of leg (left)	1.2	5.8	9.6	2.8	2.5	3.1	2.5	2.5	2.4	2.4	0.7	1.8	2.5
Comparative body size at age 10	1.2	3.3	6.7	-2.6	-1.8	-2.4	-1.6	-1.7	-1.6	-1.1	-1.2	-1.8	-1.7
Whole body fat mass	1.2	5.2	8.6	2.3	2.5	1.9	2.3	2.6	2.4	1.4	2.9	1.4	2.3
Arm predicted mass (right)	1.2	6.0	9.1	2.3	3.0	1.8	2.8	2.7	2.8	2.1	1.5	2.6	2.5
Handedness (chirality/laterality): Left-handed	1.2	1.4	4.9	1.1	1.2	0.5	1.3	1.1	1.2	2.2	0.1	1.1	1.0
Loneliness, isolation	1.2	1.7	2.9	0.6	1.7	-0.4	1.6	1.6	1.6	0.8	-0.5	1.7	1.6
Ever taken oral contraceptive pill	1.2	1.3	3.2	-0.7	-0.8	-0.9	-1.3	-1.4	-1.3	-0.6	-1.8	-1.1	-0.8
Trunk fat percentage	1.1	4.3	8.2	2.1	2.2	2.0	2.1	2.4	2.1	1.2	2.9	1.1	2.0
Prospective memory result	1.1	1.4	4.0	1.0	0.9	1.1	1.0	0.8	0.9	2.0	1.8	0.8	0.7
Ever highly irritable/argumentative for 2 days	1.1	1.3	3.9	-0.9	-1.1	-0.7	-1.2	-1.2	-1.2	-0.8	0.4	-2.0	-1.1
Illnesses of siblings: Diabetes	1.1	1.4	3.9	-1.1	-0.9	-1.3	-0.6	-0.6	-0.6	-2.0	-0.6	-1.9	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.4	8.3	1.8	1.0	2.9	1.1	0.8	1.0	2.5	0.9	1.0	0.5
Supplements: Calcium	1.1	1.3	3.2	-1.4	-0.7	-1.4	-0.8	-0.9	-0.8	-1.5	-1.8	-0.0	-0.8
Basal cell carcinoma (self-reported)	1.1	1.3	3.0	1.2	1.4	1.2	0.9	0.9	0.8	0.8	-0.6	1.7	1.3
Systolic Blood Pressure	1.0	4.9	8.8	-1.1	-3.0	0.2	-2.7	-2.6	-2.7	0.1	2.1	-2.1	-2.9
Average weekly spirits intake	1.0	1.2	2.4	-0.8	-1.3	-0.5	-1.0	-1.0	-1.0	-0.7	1.6	-1.4	-1.3
Bilateral oophorectomy (both ovaries removed)	1.0	1.1	3.2	-1.3	-0.8	-0.3	-0.8	-0.8	-0.8	-1.8	-1.5	-1.2	-0.5
High blood pressure	1.0	2.7	9.1	1.8	0.7	2.5	0.8	0.8	0.8	2.1	3.0	0.6	1.1
Sitting height	1.0	7.4	11.5	2.8	3.3	1.7	2.8	2.9	2.9	2.7	-0.1	3.4	3.0
Time employed in main current job	1.0	1.1	1.5	1.1	1.1	1.0	1.1	1.1	1.1	1.2	0.5	1.0	1.2
Medication for pain relief, constipation, heartburn	1.0	1.8	2.5	1.3	1.5	1.4	1.5	1.6	1.4	0.8	0.6	1.2	1.6
Neck or shoulder pain in last month	1.0	1.5	3.1	-1.2	-1.0	-1.5	-1.3	-1.2	-1.3	-1.8	-0.8	-0.9	-0.7
Leg fat mass (right)	1.0	3.8	7.0	1.9	2.2	1.2	2.0	2.3	2.1	1.0	2.6	1.3	2.1
Comparative height size at age 10	1.0	5.7	10.8	2.6	2.3	2.6	2.3	2.1	2.4	3.3	1.1	2.6	2.1
Vascular/heart problems diagnosed by doctor	1.0	2.8	8.7	-2.0	-0.8	-2.6	-0.8	-0.8	-0.8	-2.1	-3.0	-0.4	-1.1
Alcohol drinker status: Previous	1.0	1.2	2.9	1.2	1.3	0.9	1.0	1.0	0.9	1.7	0.8	0.7	0.9
Leg fat mass (left)	1.0	3.8	7.5	1.9	2.2	1.2	2.0	2.3	2.1	1.0	2.7	1.2	2.0
Arm predicted mass (left)	1.0	5.1	7.6	2.0	2.8	1.6	2.4	2.5	2.5	2.1	1.6	2.5	2.4
Verbal and Numeric Reasoning (VNR)	0.9	2.2	5.9	1.6	1.4	0.5	1.6	1.5	1.6	1.1	0.8	2.4	1.5
HbA1C	0.9	1.0	2.5	-1.0	-1.0	-0.6	-0.8	-0.7	-0.6	-1.4	0.7	-1.6	-0.9
Triglycerides	0.9	1.5	3.2	1.2	1.4	0.1	1.8	1.8	1.7	0.0	-0.4	0.4	1.6
Blood Platelet Count	0.9	10.2	32.4	4.7	0.9	5.7	1.4	0.7	0.8	4.6	4.6	-0.6	0.8
Impedance of leg (right)	0.9	4.1	6.5	2.2	2.1	2.6	2.1	2.2	2.0	2.2	0.1	1.7	2.2
Relative age voice broke	0.9	1.3	5.8	0.7	1.2	2.4	1.2	1.0	1.1	0.8	-0.1	-0.7	0.9
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	3.2	0.5	1.7	-0.4	1.2	1.3	1.3	0.7	-0.8	1.4	1.8
Lung cancer (father)	0.9	1.0	3.3	1.7	0.6	1.8	0.7	0.5	0.7	0.7	0.9	0.4	0.7
Arm fat-free mass (right)	0.9	4.4	6.6	1.8	2.6	1.5	2.4	2.3	2.4	1.7	1.5	2.3	2.1
Worry too long after embarrassment	0.9	1.5	2.1	1.0	1.5	1.3	1.3	1.3	1.3	1.4	-0.2	1.4	1.3
High cholesterol (Self-reported)	0.9	1.5	5.3	1.1	1.1	1.4	0.9	1.1	0.9	2.3	1.0	0.7	1.2
Arm fat-free mass (left)	0.9	4.8	6.9	1.9	2.6	1.6	2.3	2.3	2.4	2.2	1.8	2.3	2.3
Average weekly beer plus cider intake	0.9	1.3	3.0	1.7	1.2	0.9	0.9	1.0	0.8	1.4	0.2	1.2	1.3
Fractured/broken bones in last 5 years	0.9	1.2	1.9	0.9	1.2	1.3	0.9	1.2	0.9	0.7	1.4	0.8	1.3
Age started oral contraceptive pill	0.9	1.2	3.8	1.2	1.1	0.7	0.9	0.9	0.8	1.9	0.2	1.1	1.2
Blood White Count	0.8	6.0	13.4	-2.4	-2.3	-2.1	-2.1	-2.1	-1.9	-3.7	-1.9	-3.3	-2.2
Cardiovascular Disease	0.8	2.8	6.8	2.0	1.4	2.6	1.5	1.3	1.5	1.9	1.5	0.9	1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.0	1.7	0.5	1.1	0.2	1.2	1.2	1.2	0.6	-1.0	1.1	1.3
Taking other prescription medications	0.8	1.2	2.5	-1.6	-0.9	-1.5	-0.8	-0.9	-0.7	-0.8	-0.9	-1.5	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.8	5.2	-1.4	-0.7	-2.3	-1.0	-0.9	-0.9	-1.5	-2.1	-0.9	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	4.3	-1.5	-0.8	-1.9	-1.0	-1.1	-0.9	-1.5	-2.1	-1.4	-0.8
Weight	0.8	4.2	5.9	1.9	2.4	1.5	2.1	2.3	2.2	1.8	2.4	1.7	2.0
Worrier / anxious feelings	0.8	1.5	2.4	1.3	1.5	0.7	1.4	1.3	1.4	0.8	-1.0	1.0	1.5
Tense / ‘highly strung’	0.8	1.3	2.2	0.2	1.5	-0.6	1.2	1.3	1.2	0.3	-1.4	1.0	1.5
Gout (self-reported)	0.8	1.1	4.7	1.1	0.5	1.5	0.3	0.6	0.2	1.1	2.2	0.5	0.7
Body fat percentage	0.8	3.3	7.5	1.8	1.9	1.6	1.8	2.1	1.9	0.8	2.7	0.9	1.8
Number of full sisters	0.8	1.0	1.7	1.0	1.1	0.4	1.1	1.0	1.1	1.3	-0.3	1.3	1.0
Hypertension (Self-reported)	0.8	2.2	7.4	1.6	0.6	2.3	0.7	0.7	0.7	2.0	2.7	0.4	0.9
Guilty feelings	0.8	1.1	2.2	0.7	1.4	0.4	1.1	1.3	1.2	0.7	-0.0	1.1	1.5
Medication: Lisinopril	0.8	1.0	1.7	-1.1	-1.2	-0.1	-1.3	-1.3	-1.2	0.4	-0.5	-1.1	-0.9
Basal metabolic rate	0.8	4.6	6.6	1.9	2.6	1.6	2.3	2.3	2.4	2.1	1.7	2.3	2.1
Worry (Nagel 2018)	0.7	1.4	2.8	1.1	1.6	0.5	1.4	1.3	1.4	0.9	-0.3	1.2	1.7
Type 2 Diabetes (T2D) (2012)	0.7	0.8	3.5	-1.0	-0.4	-0.9	-0.3	-0.4	-0.3	-1.0	-1.9	-0.8	-0.5
Frequency of depressed mood in last 2 weeks	0.7	1.0	2.8	-0.3	1.0	-0.6	1.0	0.9	1.1	0.8	-1.1	1.7	0.9
Severe depression (siblings)	0.7	0.8	1.6	0.7	1.0	-0.5	1.3	1.3	1.3	-0.5	-0.1	0.2	1.1
Falls in the last year	0.7	0.9	5.7	-0.7	-0.1	-1.4	-0.5	-0.5	-0.5	-0.7	-2.4	-0.5	0.3
Number of live births	0.7	1.0	1.9	1.0	1.0	1.0	1.4	1.1	1.4	0.4	0.0	-0.4	1.2
Medication: Cholesterol lowering	0.7	1.1	2.8	-0.4	-1.2	0.3	-1.2	-1.4	-1.3	-0.1	-0.4	-1.7	-1.0
Mouth/teeth dental problems: Bleeding gums	0.7	1.0	1.5	-1.0	-1.0	-0.9	-1.1	-0.8	-1.1	-0.8	0.4	-1.2	-1.2
Medication: Amlodipine	0.7	1.0	2.8	0.8	0.8	1.7	0.8	0.5	0.7	1.4	1.3	0.3	0.8
Leg pain on walking	0.7	0.9	1.6	-0.8	-1.1	-1.1	-1.3	-1.0	-1.2	-0.5	0.1	-0.7	-1.1
Knee pain experienced in last month	0.7	1.0	2.0	-0.9	-0.9	-1.2	-1.4	-1.2	-1.4	-0.2	-0.7	-1.0	-0.6
Whole body fat-free mass	0.7	3.8	5.7	1.7	2.4	1.3	2.1	2.1	2.2	1.9	1.2	2.3	2.0
Wears glasses or contact lenses	0.7	0.8	1.7	0.7	0.9	0.4	0.9	0.9	1.0	0.8	1.3	0.7	1.0
Financial situation satisfaction	0.7	0.9	2.4	1.3	0.2	1.6	0.5	0.0	0.4	1.5	1.3	0.5	0.4
Impedance of whole body	0.7	3.4	7.5	2.2	1.8	2.7	1.9	2.0	1.8	1.8	0.2	1.4	1.7
Depression (Nagel 2018)	0.6	0.9	1.9	0.4	1.1	0.5	1.2	1.1	1.2	0.4	-0.2	0.9	1.4
Schizophrenia vs Biploar Disorder	0.6	0.7	1.2	0.9	1.0	0.3	1.0	1.1	1.1	-0.2	0.8	1.0	0.6
Leg fat-free mass (left)	0.6	2.9	4.5	1.5	2.1	1.1	1.8	2.0	2.0	1.3	1.3	2.0	1.7
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.2	0.9	1.0	0.8	0.8	1.1	0.9	0.3	-0.1	0.0	1.1
Medication: Simvastatin	0.6	0.9	2.2	-0.3	-1.0	-0.1	-1.2	-1.1	-1.3	0.1	-0.3	-1.5	-0.9
Trunk fat-free mass	0.6	3.7	5.5	1.6	2.3	1.3	2.0	2.0	2.1	2.3	0.9	2.3	2.0
Happiness	0.6	0.7	2.4	-1.1	-0.5	-1.6	-0.4	-0.6	-0.3	-1.0	-1.2	-0.7	-0.3
Asthma	0.6	1.2	3.2	1.1	1.2	0.8	1.2	1.2	1.2	1.8	0.2	0.5	0.9
Trunk predicted mass	0.6	3.5	5.1	1.6	2.3	1.2	1.9	1.9	2.0	2.2	0.9	2.3	1.9
Exposure to tobacco smoke at home	0.6	0.6	1.1	-1.1	-0.7	-0.8	-0.9	-0.9	-0.9	-0.4	-0.9	-0.3	-0.8
Shortness of breath walking on level ground	0.6	0.7	1.5	-1.0	-1.0	-1.2	-0.7	-0.9	-0.7	0.0	-0.2	-0.5	-1.1
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	2.6	0.7	0.4	1.2	0.7	0.5	0.6	1.2	1.6	0.8	-0.0
Supplements: Vitamin C	0.6	0.7	2.2	-0.8	-0.7	-1.5	-0.7	-0.9	-0.7	-0.7	-1.0	-0.5	-0.6
Ever had bowel cancer screening	0.6	0.7	1.8	0.6	1.0	0.4	0.6	0.9	0.6	1.0	1.3	-0.3	0.9
Friendships satisfaction	0.6	0.8	1.8	0.4	1.1	-0.5	1.1	1.0	1.2	0.2	-0.7	0.6	1.3
Asthma (self-reported)	0.6	1.3	3.1	1.1	1.2	1.0	1.2	1.3	1.3	1.8	0.2	0.5	1.0
Osteoarthritis (self-reported)	0.6	0.7	2.3	-1.0	-0.6	-1.5	-1.0	-0.7	-0.9	0.1	0.2	-0.9	-0.5
Illnesses of father: None of the above (group 1)	0.6	0.7	2.4	1.6	0.9	0.7	0.6	0.6	0.6	-0.3	-0.2	0.3	1.4
Whole body water mass	0.6	3.6	5.5	1.6	2.3	1.3	2.0	2.0	2.1	1.9	1.2	2.2	1.9
Leg fat percentage (left)	0.6	2.0	6.9	1.4	1.4	0.7	1.4	1.6	1.4	0.2	2.6	0.4	1.5
Commuting to job workplace: Cycle	0.6	0.7	1.7	0.9	0.8	0.5	0.6	0.9	0.6	1.1	1.3	0.8	0.8
Systolic blood pressure, automated reading	0.5	1.4	7.1	0.3	-0.9	0.5	-1.0	-1.0	-1.1	1.3	2.7	-0.0	-0.6
Leg predicted mass (left)	0.5	2.7	4.2	1.5	2.0	1.1	1.8	1.9	1.9	1.2	1.2	1.9	1.6
Hearing difficulty/problems with background noise	0.5	0.7	2.1	0.6	1.0	-0.1	0.7	1.0	0.7	1.5	0.9	0.6	0.8
Mouth/teeth dental problems: Dentures	0.5	0.8	3.2	0.8	0.6	0.3	0.6	0.4	0.6	1.3	0.3	1.8	1.0
Depression (self-reported)	0.5	0.6	2.3	-1.5	-0.3	-1.2	-0.3	-0.4	-0.3	0.9	-0.9	0.2	-0.5
Arm fat mass (right)	0.5	2.1	6.1	1.3	1.5	1.1	1.4	1.6	1.5	0.8	2.5	0.8	1.3
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.0	0.6	0.7	0.9	1.0	1.0	1.0	0.7	0.1	0.2	0.8
Leg fat percentage (right)	0.5	1.9	5.7	1.2	1.4	0.7	1.3	1.7	1.4	0.3	2.4	0.5	1.5
Eye problems/disorders: None of the above	0.5	0.6	1.1	0.9	0.7	1.0	0.9	0.8	0.9	0.4	0.0	0.3	0.9
Had major operations	0.5	0.6	2.0	-0.3	0.0	-1.3	-0.3	0.0	-0.2	-1.4	-1.2	-0.4	0.2
Family relationship satisfaction	0.5	0.7	3.4	-0.6	0.4	-1.4	0.1	-0.1	0.1	0.3	-1.8	0.7	0.4
Leg fat-free mass (right)	0.5	2.6	3.8	1.6	1.9	1.2	1.7	1.8	1.8	1.2	1.4	1.8	1.4
Commuting to job workplace: Walk	0.5	0.5	1.2	-0.5	-0.7	-0.3	-0.8	-0.9	-0.8	1.1	-0.3	-0.7	-0.5
Leg predicted mass (right)	0.5	2.5	3.6	1.5	1.9	1.2	1.7	1.7	1.8	1.2	1.4	1.8	1.4
Arm fat mass (left)	0.5	2.1	6.7	1.3	1.4	1.1	1.4	1.6	1.5	0.7	2.6	0.7	1.2
Intelligence (Savage-Jansen 2018)	0.4	1.4	6.9	0.7	0.8	0.1	1.0	0.9	0.9	1.4	0.6	2.6	0.9
Alzheimer’s Disease (in mother)	0.4	0.5	3.3	0.3	0.5	-0.6	0.2	0.6	0.2	-0.1	0.4	1.8	0.5
Prostate Cancer	0.4	0.6	1.2	0.6	0.7	0.8	0.9	0.8	0.9	-0.6	1.1	0.4	0.8
Coronary Artery Disease (CAD)	0.4	0.5	3.1	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.8	1.2
Smoking Status	0.4	0.9	1.3	-0.5	-1.0	-0.5	-1.1	-1.1	-1.1	-0.9	0.9	-0.5	-1.1
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	0.5	-0.7	-0.7	-0.6	-0.7	-0.7	-0.7	-0.4	-0.4	-0.7	-0.7
Vitamin and mineral supplements	0.4	0.6	1.9	0.7	0.5	1.0	0.8	0.6	0.7	0.7	1.4	0.1	0.6
Qualifications: CSEs or equivalent	0.4	0.5	1.3	1.2	0.7	1.0	0.8	0.7	0.7	0.2	-0.3	0.1	0.7
Serious illness, injury or assault to yourself	0.4	0.5	1.0	0.6	0.9	0.5	0.7	1.0	0.8	0.7	0.0	-0.3	0.9
Medication: Atenolol	0.4	0.5	1.1	-0.2	-0.9	-0.1	-0.7	-0.8	-0.7	-0.3	0.7	-1.0	-0.9
Hair/balding pattern: Pattern 4	0.4	1.1	5.1	-0.3	0.7	-1.5	0.4	0.4	0.4	-0.6	-2.3	1.2	0.6
Birth weight of first child	0.4	0.8	1.9	0.5	0.8	1.4	1.0	0.9	1.0	1.1	-0.2	0.9	0.6
Peak expiratory flow (PEF)	0.4	1.0	1.6	1.0	1.1	1.1	1.1	1.3	1.1	0.6	0.7	0.7	0.9
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.4	0.2	1.0	0.8	0.7	0.8	0.7	1.1	0.2	1.2	0.5
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	1.5	-0.9	0.4	-1.2	0.4	0.5	0.5	-0.9	-0.8	1.1	0.3
High blood pressure (siblings)	0.4	0.6	1.1	-0.6	-0.7	1.1	-0.6	-0.7	-0.7	0.8	1.1	-0.7	-0.8
Wheeze or whistling in the chest in last year	0.4	0.6	1.4	0.5	1.2	0.6	0.8	1.1	0.9	0.5	0.2	0.2	1.2
Qualifications: College or University degree	0.4	1.3	3.4	-1.3	-0.8	-1.8	-1.3	-1.0	-1.2	0.1	0.9	-0.6	-1.2
Qualifications: nursing, teaching	0.4	0.7	3.0	0.4	0.6	-0.3	0.7	0.9	0.7	0.5	1.7	1.0	0.5
Ever depressed for a whole week	0.4	0.5	1.1	-0.7	-0.7	-0.4	-0.7	-1.0	-0.6	-0.3	-1.0	-0.9	-0.6
Depressed Affect (Nagel 2018)	0.3	0.6	1.5	-1.1	-0.4	-1.2	-0.6	-0.7	-0.6	-1.1	-0.7	-0.6	-0.3
Alzheimer’s Disease (including proxy)	0.3	0.5	2.2	-0.3	-0.1	-1.5	-0.2	-0.1	-0.2	-0.6	-1.3	0.5	-0.1
Major Depression (MDD)	0.3	0.4	3.1	0.2	-0.0	0.2	0.3	0.2	0.4	0.2	-0.3	-1.8	-0.2
Neuroticism (2016)	0.3	0.4	1.4	-0.0	-0.6	0.2	-0.6	-0.8	-0.7	-0.3	-0.9	-1.2	-0.6
Maternal smoking around birth	0.3	0.4	1.5	-0.4	-0.5	-0.3	-0.7	-0.7	-0.6	-1.2	-0.6	-0.6	-0.5
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.5	0.5	1.2	-0.5	0.8	1.1	1.0	-0.3	-0.2	-0.3	0.9
Chronic bronchitis/emphysema (father)	0.3	0.3	0.5	0.3	0.7	0.5	0.6	0.6	0.6	0.7	0.4	0.4	0.6
High blood pressure (mother)	0.3	0.5	2.0	0.5	-0.3	1.4	-0.3	-0.2	-0.3	0.9	0.9	-0.5	-0.1
Alcohol usually taken with meals	0.3	0.5	1.4	-1.2	-0.5	-1.1	-0.5	-0.3	-0.4	-0.2	-1.1	-0.1	-0.3
Financial difficulties in last 2 years	0.3	0.4	2.3	0.4	0.5	-0.4	0.3	0.5	0.3	0.0	0.1	1.5	0.6
Hip circumference	0.3	1.1	4.1	0.6	1.2	0.1	0.9	1.1	1.0	0.7	2.0	1.1	0.8
Illnesses of mother	0.3	0.3	1.3	0.1	0.7	-1.1	0.3	0.3	0.4	-0.6	-0.7	0.5	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.5	-0.6	0.5	-1.2	0.2	0.3	0.3	0.1	-1.2	0.3	0.4
Glaucoma (self-reported)	0.3	0.4	0.8	0.1	0.9	0.2	0.6	0.8	0.6	-0.1	-0.2	0.8	0.8
Medication: Ventolin 100micrograms inhaler	0.3	0.4	2.4	0.4	-0.0	1.5	-0.2	-0.2	-0.2	1.1	0.4	0.1	-0.2
Number of full brothers	0.3	0.3	1.0	-0.2	-0.7	0.2	-0.5	-0.6	-0.5	-0.7	-0.1	-1.0	-0.5
Medication: Allopurinol	0.3	0.4	1.5	-0.1	-0.7	0.1	-0.7	-0.6	-0.7	0.0	1.2	-0.5	-0.3
Alcohol intake frequency.	0.3	0.8	2.2	-0.6	-0.6	-0.9	-0.6	-0.6	-0.6	-1.0	-1.5	-1.5	-0.5
Illnesses of father: Heart disease	0.3	0.4	2.0	-0.2	0.5	-0.1	0.5	0.3	0.5	1.4	0.4	1.1	0.2
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.9	0.2	-0.4	-0.4	-0.4	-0.5	-0.5	0.9	-1.0	0.7	-0.1
Commuting to job workplace: Public transport	0.3	0.4	0.8	-0.3	-0.7	-0.9	-0.8	-0.8	-0.8	0.3	0.2	0.2	-0.5
Medication: Blood pressure	0.3	0.5	2.3	-0.5	-0.9	0.1	-0.7	-0.6	-0.6	-0.0	1.5	-0.8	-0.4
Medication: Paracetamol	0.3	0.5	2.2	-0.8	0.0	-1.5	-0.3	-0.3	-0.2	-0.6	-1.3	0.2	-0.1
Irritability	0.3	0.5	1.4	-1.1	-0.3	-1.2	-0.3	-0.2	-0.3	-0.5	-1.1	-0.8	-0.4
Risk taking	0.3	0.4	1.2	-0.2	0.0	-1.1	-0.5	-0.1	-0.4	-1.0	0.6	-1.1	0.0
Body Mass Index (BMI) (2010)	0.2	0.2	0.9	-0.3	0.2	-1.0	0.4	0.4	0.4	-0.3	-0.7	-0.3	0.1
BMI	0.2	1.2	3.6	-1.1	-0.5	-1.9	-0.5	-0.4	-0.3	-1.8	1.3	-1.0	-0.6
Tanning	0.2	1.9	6.7	0.8	1.4	-0.6	1.0	1.3	1.1	-0.7	-2.6	1.8	1.5
Number of treatments/medications taken	0.2	0.3	0.5	-0.7	-0.5	-0.6	-0.6	-0.7	-0.6	0.4	-0.2	-0.6	-0.4
Relative age of first facial hair	0.2	0.4	1.2	-0.3	-0.4	1.1	-0.4	-0.4	-0.4	0.7	0.4	-0.7	-0.7
Ever used hormone-replacement therapy (HRT)	0.2	0.3	1.4	-0.4	-0.3	0.4	-0.4	-0.5	-0.4	-1.2	0.0	-0.5	-0.2
Ever had hysterectomy (womb removed)	0.2	0.2	0.9	-0.3	-0.2	-0.0	-0.3	-0.5	-0.2	-0.6	-0.9	-0.9	-0.0
Fed-up feelings	0.2	0.3	1.3	-0.8	0.1	-0.9	0.1	0.1	0.1	-0.7	-1.1	0.1	0.2
Age when periods started (menarche)	0.2	0.5	4.1	0.7	-0.1	2.0	0.1	-0.2	-0.0	0.7	0.2	0.4	-0.3
Multivitamins +/- minerals	0.2	0.2	0.5	-0.4	-0.4	-0.7	-0.4	-0.4	-0.4	-0.5	-0.7	-0.1	-0.6
Number of incorrect matches in round	0.2	0.4	0.9	-0.7	-0.3	-0.8	-0.2	-0.5	-0.2	-0.7	-0.9	-0.7	0.0
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	1.0	0.2	0.5	0.2	0.7	0.4	0.7	0.5	-1.0	0.1	0.6
Mouth/teeth dental problems	0.2	0.3	1.3	-0.2	-0.3	0.4	-0.4	-0.3	-0.3	-1.0	-0.4	-1.1	-0.4
Allergy	0.2	0.6	1.4	-0.6	-1.2	0.5	-0.7	-1.0	-0.8	-0.3	0.8	-0.1	-0.9
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	1.2	-1.1	-0.5	-0.2	-0.6	-0.5	-0.5	-0.3	-0.2	-0.6	-0.5
Arm fat percentage (right)	0.2	0.7	4.0	0.6	0.7	0.3	0.6	1.0	0.7	-0.1	2.0	-0.0	0.6
Noisy workplace	0.2	0.3	1.1	0.4	-0.4	0.5	-0.5	-0.6	-0.5	-0.0	0.5	-1.0	-0.1
Impedance of arm (left)	0.2	0.8	2.4	0.9	0.6	1.6	0.8	0.9	0.8	0.8	-0.7	0.6	0.5
Breastfed as a baby	0.2	0.2	0.9	-0.8	-0.3	-0.9	-0.6	-0.3	-0.5	0.1	-0.3	0.2	-0.1
Loud music exposure frequency	0.2	0.2	0.5	0.2	0.6	0.1	0.4	0.5	0.4	0.5	0.2	0.6	0.7
Medication: Paracetamol	0.2	0.3	1.8	-0.6	0.3	-1.3	0.0	0.1	0.1	-0.3	-1.0	0.0	0.0
Headache pain in last month	0.2	0.3	1.2	-0.7	-0.1	-0.8	-0.3	-0.3	-0.3	-0.3	-1.1	-0.6	-0.2
Exposure to tobacco smoke outside home	0.2	0.3	1.2	-0.2	-0.4	1.1	-0.4	-0.5	-0.4	-0.1	0.6	-0.9	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	1.5	0.4	0.2	0.4	0.1	0.1	0.1	1.0	1.2	0.2	0.3
Emphysema/chronic bronchitis	0.2	0.3	0.8	0.9	0.3	0.8	0.2	0.3	0.2	0.4	0.2	0.8	0.3
Medication: Blood pressure	0.2	0.4	0.9	0.8	-0.3	0.8	-0.4	-0.4	-0.4	1.0	0.6	-0.7	-0.3
Migraine (self-reported)	0.2	0.2	0.4	0.3	0.5	-0.2	0.5	0.5	0.5	0.5	0.5	0.6	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	1.3	0.0	-0.0	0.2	0.2	0.1	0.1	-0.0	1.2	-0.5	-0.4
Overall health rating	0.2	0.4	0.6	0.8	0.7	0.6	0.4	0.5	0.5	-0.2	0.8	-0.7	0.7
Age at last live birth	0.2	0.3	1.5	-0.0	-0.4	0.7	0.0	-0.2	-0.1	1.2	0.6	-0.3	-0.7
Arm fat percentage (left)	0.2	0.9	4.4	0.7	0.8	0.5	0.8	1.1	0.9	-0.2	2.1	-0.1	0.6
Mouth/teeth dental problems: Mouth ulcers	0.2	0.2	1.0	-0.6	0.1	-1.0	-0.1	-0.2	-0.1	-0.2	-0.9	0.1	0.3
Medication for cholesterol	0.2	0.3	1.4	-0.5	-0.3	-1.2	-0.5	-0.3	-0.5	-0.5	-0.6	0.3	-0.7
Breast cancer (self-reported)	0.2	0.2	0.5	0.7	0.3	0.7	0.6	0.3	0.5	-0.4	-0.1	-0.3	0.3
Number of self-reported non-cancer illnesses	0.2	0.3	1.5	0.0	-0.0	-0.0	-0.3	-0.2	-0.2	1.2	0.8	-0.6	0.0
Average weekly champagne plus white wine intake	0.2	0.3	1.9	-0.6	-0.2	-0.4	-0.5	-0.2	-0.5	0.0	1.4	0.4	-0.2
Hearing aid user	0.2	0.2	0.7	0.6	0.7	0.0	0.4	0.4	0.4	0.2	-0.2	-0.4	0.8
Alcohol drinker status: Never	0.2	0.2	0.9	0.2	-0.3	-0.9	-0.1	-0.1	-0.1	-0.7	0.3	-0.4	0.0
Unable to work because of sickness or disability	0.2	0.2	0.5	0.3	0.7	0.3	0.5	0.5	0.5	0.4	-0.3	0.4	0.5
Pain experienced in last month	0.2	0.3	1.8	0.4	0.0	0.3	0.2	0.3	0.2	0.3	1.4	0.5	-0.2
Neuroticism (Nagel 2018)	0.1	0.2	0.5	-0.2	0.4	-0.5	0.2	0.2	0.3	-0.1	-0.6	0.3	0.7
Ovarian Cancer	0.1	0.2	1.2	0.4	0.1	0.2	0.0	0.1	0.0	0.7	1.1	-0.1	0.1
Primary Biliary Cirrhosis	0.1	0.2	0.6	-0.2	-0.8	-0.5	-0.4	-0.5	-0.5	-0.1	-0.3	0.2	-0.5
Rheumatoid Arthritis	0.1	0.2	0.7	0.9	0.3	-0.0	-0.2	-0.1	-0.2	0.5	0.8	-0.4	0.2
Blood Eosinophil Count	0.1	1.0	1.8	1.0	1.1	1.2	1.0	1.1	1.1	-0.4	1.4	-0.3	1.0
Waist Hip Ratio (WHR)	0.1	0.5	1.2	0.1	-0.8	-0.0	-1.0	-0.8	-1.1	0.6	-0.0	-0.2	-1.1
Allergy or Eczema	0.1	0.3	0.6	0.3	0.8	-0.6	0.4	0.7	0.5	-0.1	0.0	-0.6	0.5
Respiratory disease	0.1	0.2	0.6	0.8	0.5	0.3	0.5	0.7	0.6	0.5	0.0	-0.3	0.3
Neuroticism	0.1	0.2	0.6	-0.2	0.5	-0.8	0.4	0.1	0.4	-0.4	-0.8	0.2	0.6
Chronotype (morning person)	0.1	0.2	0.6	-0.3	0.4	-0.7	0.4	0.4	0.5	0.4	-0.2	-0.4	0.8
Hearing difficulty/problems: Yes	0.1	0.1	0.4	0.3	0.0	-0.4	-0.1	-0.1	-0.2	0.6	0.6	0.0	0.0
Angina	0.1	0.2	0.8	0.3	0.0	-0.9	-0.3	-0.3	-0.3	-0.4	-0.5	-0.6	-0.0
Medication for hormone replacement therapy	0.1	0.2	0.6	0.1	0.3	0.8	0.4	0.1	0.4	-0.2	-0.5	0.5	-0.0
Medication: Co-codamol	0.1	0.1	0.3	0.4	0.3	-0.4	0.1	0.3	0.2	-0.2	-0.3	-0.0	0.5
Current tobacco smoking	0.1	0.1	0.7	0.1	-0.1	-0.5	-0.0	-0.1	-0.0	-0.8	-0.6	0.0	0.0
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.8	-0.3	0.3	0.1	0.0	-0.0	0.0	0.2	-0.0	0.9	0.2
Body mass index (BMI)	0.1	0.6	4.3	-0.2	0.1	-0.6	0.0	0.2	0.1	-0.7	2.1	-0.5	-0.0
Waist circumference	0.1	0.4	3.3	0.3	0.5	-0.1	0.2	0.4	0.3	0.6	1.8	0.3	0.2
Nervous feelings	0.1	0.2	0.5	0.1	0.6	0.3	0.2	0.2	0.2	0.7	-0.3	0.4	0.6
Qualifications: None of the above	0.1	0.3	1.1	1.0	0.1	1.0	0.3	0.1	0.3	0.6	-0.1	-0.2	0.2
Pain all over the body in last month	0.1	0.1	0.4	-0.0	0.3	0.0	0.1	0.1	0.2	-0.6	0.2	-0.2	0.3
Medication: Ramipril	0.1	0.2	0.3	0.1	-0.4	0.1	-0.2	-0.5	-0.3	0.6	0.4	-0.4	-0.6
Neuroticism score	0.1	0.2	0.8	-0.2	0.5	-0.5	0.4	0.3	0.4	0.1	-0.9	0.4	0.5
Impedance of arm (right)	0.1	0.7	1.5	0.7	0.6	1.2	0.6	0.9	0.6	1.0	-1.0	0.6	0.7
Alcohol intake versus 10 years previously	0.1	0.2	0.5	-0.2	-0.4	-0.4	-0.5	-0.7	-0.5	-0.2	-0.7	-0.5	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	1.0	0.2	0.2	-1.0	0.3	0.3	0.3	-0.3	-0.1	-0.5	0.1
Qualifications: A levels/AS levels or equivalent	0.1	0.3	1.4	-0.3	-0.1	-0.9	-0.2	-0.0	-0.1	1.2	-0.1	0.8	-0.4
Medication: Lansoprazole	0.1	0.2	0.4	-0.3	-0.3	-0.5	-0.3	-0.4	-0.3	-0.5	-0.2	-0.6	-0.2
Length of working week for main job	0.1	0.1	0.4	0.3	0.5	0.7	0.2	0.3	0.2	-0.2	-0.5	0.0	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.4	0.3	0.2	-0.4	-0.1	0.1	-0.0	0.1	-0.5	0.0	0.6
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.3	0.2	0.3	-0.4	0.4	0.6	0.4	-0.3	-0.1	-0.3	0.1
Angina (self-reported)	0.1	0.2	0.6	0.4	0.0	-0.8	-0.3	-0.3	-0.3	-0.5	-0.3	-0.6	-0.0
Heart disease (mother)	0.1	0.2	0.4	-0.3	-0.5	0.0	-0.4	-0.4	-0.4	0.1	-0.4	-0.5	-0.7
Chest pain or discomfort	0.1	0.1	0.3	0.3	0.2	-0.5	-0.0	0.3	0.1	-0.2	0.1	-0.5	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.7	-0.0	-0.3	0.5	-0.2	-0.2	-0.2	0.3	0.8	-0.3	-0.4
Commuting to job workplace: Car/motor vehicle	0.1	0.2	1.2	-0.3	-0.2	-0.2	-0.3	-0.2	-0.2	-1.1	0.2	-0.3	-0.1
Eye problems/disorders: Cataract	0.1	0.2	0.7	0.5	0.3	0.5	0.3	0.1	0.3	0.2	0.8	0.4	-0.1
Osteoporosis (self-reported)	0.1	0.1	0.5	-0.0	0.2	0.7	0.4	0.3	0.3	-0.2	0.7	0.1	0.1
Miserableness	0.1	0.2	1.3	-0.7	-0.2	-1.1	-0.0	-0.2	-0.1	-0.5	-0.5	-0.3	-0.1
Eye problems/disorders: Glaucoma	0.1	0.1	0.2	0.0	0.4	0.2	-0.0	0.1	-0.0	-0.1	0.3	0.5	0.4
Pain type(s) experienced in last month: Hip pain	0.1	0.2	0.5	-0.4	-0.2	-0.7	-0.1	-0.1	-0.0	-0.5	0.3	-0.6	-0.3
Medication: Bendroflumethiazide	0.1	0.2	0.4	0.1	-0.5	0.3	-0.6	-0.6	-0.6	0.3	0.6	-0.0	-0.4
Illnesses of father: High blood pressure	0.1	0.1	0.3	-0.5	-0.2	0.4	-0.3	-0.2	-0.4	-0.3	0.1	-0.3	-0.2
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.5	-0.6	0.0	0.1	0.0	0.1	0.0	0.4	0.7	0.7	0.1
Myopia	0.1	0.2	0.7	-0.4	-0.3	0.6	-0.3	-0.2	-0.2	-0.1	-0.8	-0.3	-0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Back pain experienced in last month	0.0	0.1	0.2	0.1	0.1	-0.1	-0.3	-0.3	-0.2	0.4	0.1	0.3	0.4
Smoking status: Current	0.0	0.1	0.4	0.3	-0.0	-0.3	0.1	-0.1	0.1	-0.6	-0.2	-0.0	0.0

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Trait associations