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chr8:21,249,296-26,469,222

Best TWAS P=1.1e-20 · Best GWAS P=3.39e-26 conditioned to 8e-17

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adrenal Gland	KCTD9	0.23	-0.01	lasso	6	0.00	3.8e-01	-6.4	-6.0	1.7e-09	0.09	0.08	0.23	FALSE
2	GTEx	Brain Putamen basal ganglia	LOXL2	0.48	0.01	enet	8	0.00	3.8e-01	3.0	6.0	2.6e-09	0.33	0.05	0.42	TRUE
3	GTEx	Esophagus Gastroesophageal Junction	PIWIL2	0.13	0.07	lasso	3	0.03	2.4e-02	-4.9	-5.4	8.5e-08	0.03	0.16	0.07	FALSE
4	GTEx	Esophagus Muscularis	LOXL2	0.19	0.06	lasso	6	0.07	6.0e-05	8.1	6.7	2.2e-11	0.84	0.02	0.98	TRUE
5	GTEx	Muscle Skeletal	KCTD9	0.11	0.07	lasso	5	0.06	7.9e-07	-7.3	-7.7	1.6e-14	0.07	0.16	0.84	FALSE
6	GTEx	Skin Sun Exposed Lower leg	R3HCC1	0.16	0.08	enet	14	0.11	2.0e-09	5.4	-6.2	6.0e-10	-0.49	0.98	0.01	FALSE
7	GTEx	Testis	PPP3CC	0.38	0.20	enet	12	0.28	6.4e-13	5.3	-5.3	1.2e-07	-0.01	0.92	0.08	FALSE
8	METSIM	Adipose	ADAMDEC1	0.05	0.02	blup	358	0.02	1.6e-04	3.9	5.2	2.5e-07	-0.02	0.25	0.12	FALSE
9	NTR	Blood	R3HCC1	0.02	0.01	enet	13	0.02	6.7e-06	-5.3	5.9	2.7e-09	0.42	0.88	0.08	FALSE
10	ROSMAP	Brain Pre-frontal Cortex	FAM160B2	0.07	0.01	blup	430	0.04	2.2e-05	5.4	5.3	1.5e-07	0.05	0.13	0.06	FALSE
11	ROSMAP	Brain Pre-frontal Cortex	BMP1	0.05	0.00	bslmm	471	0.02	2.0e-03	5.3	5.9	4.3e-09	0.00	0.09	0.06	FALSE
12	YFS	Blood	KCTD9	0.04	0.04	lasso	8	0.04	7.8e-12	-6.4	6.4	1.3e-10	-0.07	1.00	0.00	FALSE
13	YFS	Blood	R3HCC1	0.03	0.01	lasso	6	0.01	5.3e-04	-5.7	5.4	8.2e-08	0.28	0.81	0.01	FALSE
14	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	SLC39A14	0.04	0.02	enet	6	0.03	1.1e-03	5.2	-5.3	1.1e-07	-0.07	0.03	0.68	FALSE
15	The Cancer Genome Atlas	Breast Invasive Carcinoma	ADAM28	0.06	0.06	blup	73	0.08	4.4e-16	-8.5	7.3	3.7e-13	0.03	0.95	0.05	FALSE
16	The Cancer Genome Atlas	Breast Invasive Carcinoma	PPP3CC	0.02	0.01	lasso	4	0.01	1.1e-02	5.0	-5.6	2.4e-08	-0.06	0.03	0.88	FALSE
17	The Cancer Genome Atlas	Breast Invasive Carcinoma	SLC39A14	0.02	0.01	blup	64	0.01	1.6e-03	5.0	-5.9	3.0e-09	-0.01	0.07	0.88	TRUE
18	The Cancer Genome Atlas	Breast Invasive Carcinoma	STC1	0.04	0.05	enet	7	0.06	8.9e-12	-6.0	5.6	2.1e-08	-0.04	0.00	1.00	TRUE
19	The Cancer Genome Atlas	Colon Adenocarcinoma	ADAM28	0.06	0.04	enet	5	0.04	1.9e-03	-8.4	8.6	1.1e-17	0.02	0.09	0.17	FALSE
20	The Cancer Genome Atlas	Glioblastoma Multiforme	ADAM28	0.20	0.15	lasso	5	0.18	4.3e-06	-8.2	9.1	1.4e-19	0.03	0.24	0.70	FALSE
21	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ADAM28	0.05	0.03	blup	73	0.03	1.1e-04	-8.4	9.3	1.1e-20	0.05	0.24	0.70	TRUE
22	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ADAM28	0.06	0.07	blup	73	0.06	9.5e-08	-8.5	7.5	4.4e-14	0.04	0.97	0.03	FALSE
23	The Cancer Genome Atlas	Brain Lower Grade Glioma	ADAM28	0.09	0.09	enet	10	0.10	6.6e-12	-8.1	8.9	5.8e-19	0.06	0.99	0.01	FALSE
24	The Cancer Genome Atlas	Lung Adenocarcinoma	ADAM28	0.02	0.02	blup	73	0.02	1.5e-03	-8.4	9.0	1.7e-19	0.03	0.10	0.42	FALSE
25	The Cancer Genome Atlas	Lung Adenocarcinoma	KCTD9	0.03	0.01	blup	75	0.01	1.1e-02	-8.5	-8.8	1.5e-18	0.08	0.02	0.74	TRUE
26	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ADAM28	0.02	0.03	lasso	1	0.03	3.5e-04	-8.5	8.5	2.5e-17	0.04	0.31	0.16	FALSE
27	The Cancer Genome Atlas	Prostate Adenocarcinoma	ADAM28	0.08	0.07	blup	73	0.11	7.0e-12	-8.5	8.4	4.7e-17	0.02	0.32	0.68	FALSE
28	The Cancer Genome Atlas	Prostate Adenocarcinoma	CHMP7	0.03	0.03	blup	89	0.01	3.8e-02	2.6	-6.3	2.2e-10	-0.46	0.06	0.10	FALSE
29	The Cancer Genome Atlas	Thyroid Carcinoma	ADAM28	0.06	0.03	lasso	2	0.03	8.9e-04	-7.0	7.7	1.7e-14	0.04	0.16	0.61	FALSE
30	The Cancer Genome Atlas	Thyroid Carcinoma	CHMP7	0.10	0.02	lasso	6	0.04	5.4e-05	2.6	-6.1	1.0e-09	-0.38	0.24	0.22	TRUE
31	The Cancer Genome Atlas	Thyroid Carcinoma	PPP2R2A	0.13	0.01	blup	582	0.05	2.3e-05	-4.8	5.5	4.1e-08	0.04	0.46	0.02	TRUE