TWAS hub - ADAM28

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellar Hemisphere	0.4710	0.0900	2.1e-05	0.015	NA	0.005	NA	-0.009	1.3e-01	NA	2.3e-01	NA	6.4e-01
2	GTEx	Whole Blood	0.1040	0.0440	9.9e-04	0.004	NA	-0.003	NA	0.000	1.3e-01	NA	7.0e-01	NA	3.5e-01
3	NTR	Blood	0.0176	0.0083	5.5e-03	0.003	0.002	0.009	0.003	0.009	3.6e-02	6.0e-02	3.8e-04	0.037	5.4e-04
4	YFS	Blood	0.0484	0.0143	1.1e-07	0.006	0.024	0.024	NA	0.026	4.8e-03	1.5e-08	1.7e-08	NA	5.8e-09
5	TCGA	Breast Invasive Carcinoma	0.0562	0.0197	1.1e-14	0.063	0.080	0.078	NA	0.078	8.2e-13	4.4e-16	1.1e-15	NA	1.1e-15
6	TCGA	Colon Adenocarcinoma	0.0560	0.0350	7.6e-03	0.043	0.016	0.042	NA	0.028	1.7e-03	3.8e-02	1.8e-03	NA	9.8e-03
7	TCGA	Glioblastoma Multiforme	0.1960	0.0890	1.4e-05	0.154	0.176	0.109	NA	0.178	2.1e-05	4.9e-06	3.5e-04	NA	4.3e-06
8	TCGA	Head and Neck Squamous Cell Carcinoma	0.0471	0.0248	7.9e-05	0.026	0.033	0.018	NA	0.024	5.9e-04	1.1e-04	3.4e-03	NA	9.4e-04
9	TCGA	Kidney Renal Clear Cell Carcinoma	0.0559	0.0241	4.9e-07	0.067	0.064	0.060	NA	0.056	5.6e-08	9.5e-08	2.3e-07	NA	6.1e-07
10	TCGA	Brain Lower Grade Glioma	0.0851	0.0369	2.3e-09	0.092	0.093	0.105	NA	0.092	1.2e-10	1.0e-10	6.6e-12	NA	1.2e-10
11	TCGA	Lung Adenocarcinoma	0.0238	0.0143	3.8e-03	0.018	0.021	0.011	NA	0.016	3.1e-03	1.5e-03	1.6e-02	NA	5.3e-03
12	TCGA	Lung Squamous Cell Carcinoma	0.0227	0.0135	2.9e-03	0.030	0.021	0.024	NA	0.028	1.9e-04	1.7e-03	8.6e-04	NA	3.5e-04
13	TCGA	Prostate Adenocarcinoma	0.0801	0.0335	4.1e-10	0.075	0.113	0.095	NA	0.087	3.1e-08	7.0e-12	3.5e-10	NA	2.3e-09
14	TCGA	Thyroid Carcinoma	0.0550	0.0370	1.3e-03	0.029	0.020	0.021	NA	0.028	7.2e-04	4.4e-03	3.4e-03	NA	8.9e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	2	3	4	5	6	7	8	9	10	11	12	13	14
Ever had stillbirth, spontaneous miscarriage or termination	6.8	7.3	15.8	-0.3	-0.2	1.5	3.0	1.7	4.0	2.8	3.2	3.4	3.3	3.9	3.5	2.1
Height	6.3	120.6	201.6	0.9	1.6	6.6	11.7	13.1	13.5	14.2	11.4	12.9	14.0	12.6	12.3	12.1
Standing height	5.2	51.9	87.0	0.1	0.3	3.6	7.3	8.6	9.1	9.3	7.5	8.9	9.0	8.5	8.4	7.7
Supplements: Vitamin C	4.4	5.2	9.1	-0.4	-1.3	-2.2	-2.7	-1.6	-2.7	-2.6	-3.0	-3.0	-2.8	-2.9	-2.2	-2.0
HbA1C	4.2	4.7	9.4	-0.4	1.1	1.4	2.1	3.1	2.6	2.9	1.8	2.4	2.3	2.2	2.9	2.5
Ever had hysterectomy (womb removed)	3.9	4.4	8.0	-0.9	-2.1	-2.1	-2.8	-1.8	-2.4	-1.6	-2.3	-1.8	-2.4	-2.4	-2.1	-2.8
Hand grip strength (left)	3.7	9.8	21.6	-1.4	0.4	1.1	2.6	4.4	3.5	4.6	3.2	4.2	3.3	3.3	4.0	3.0
Mother’s age at death	3.7	4.7	9.1	-0.4	2.7	0.7	-1.3	-1.9	-2.9	-2.1	-2.0	-2.3	-2.4	-2.6	-2.7	-3.0
Forced expiratory volume in 1-second (FEV1), predicted	3.6	7.6	12.4	-0.3	0.5	2.0	3.3	2.9	3.5	3.5	3.0	3.1	3.5	3.2	3.0	3.0
Reason for reducing amount of alcohol drunk: Health precaution	3.4	3.9	7.6	-1.0	-1.2	-2.0	-2.4	-1.8	-2.1	-1.8	-2.4	-2.1	-2.4	-2.3	-1.8	-2.8
Risk taking	3.4	5.0	9.9	-1.8	0.1	0.6	2.1	2.8	2.8	3.1	1.8	2.1	2.2	2.4	2.8	3.1
Leg pain on walking	3.2	4.0	7.1	-1.6	-0.4	-2.7	-2.6	-1.1	-2.0	-1.2	-2.6	-2.5	-2.1	-2.4	-1.9	-2.3
Medication for cholesterol	3.0	4.5	8.2	0.9	0.5	1.6	2.3	2.8	2.6	2.5	2.1	2.3	2.9	2.1	2.3	2.4
Medication: Simvastatin	2.9	4.2	7.4	-1.9	-2.5	-2.6	-2.6	-1.8	-2.3	-1.7	-2.0	-2.0	-2.7	-2.1	-1.3	-1.5
Medication: Ibuprofen (e.g. Nurofen)	2.9	3.6	7.6	1.2	0.1	-0.1	-1.7	-2.1	-2.7	-2.3	-1.7	-1.4	-2.2	-2.5	-2.8	-2.5
Hearing aid user	2.9	3.3	7.2	-0.6	2.4	1.8	1.9	0.8	1.9	1.7	2.3	2.7	1.6	2.1	2.1	1.5
Supplements: Fish oil (including cod liver oil)	2.8	3.6	6.0	-1.0	0.2	-1.2	-2.3	-2.4	-2.4	-2.3	-1.7	-2.0	-2.4	-2.2	-1.9	-2.1
Triglycerides	2.6	4.3	8.7	-1.2	0.2	1.2	2.1	2.2	2.4	3.0	2.3	2.5	2.3	2.2	2.3	2.5
Basal cell carcinoma (self-reported)	2.5	3.0	6.2	1.9	0.6	1.6	2.0	2.2	1.9	1.3	1.4	1.4	2.0	1.8	1.8	2.5
Trunk predicted mass	2.4	13.5	22.6	0.8	0.9	2.6	3.9	3.7	4.4	4.7	4.3	4.8	4.6	4.3	3.5	4.0
Depression (Nagel 2018)	2.3	3.4	9.9	1.1	1.4	0.7	-1.3	-3.1	-2.0	-2.3	-0.8	-0.9	-1.7	-1.9	-2.7	-2.8
Hearing difficulty/problems: Yes	2.3	3.6	7.1	0.8	1.4	-1.1	-2.0	-2.6	-2.0	-2.5	-1.8	-1.7	-1.9	-1.9	-2.1	-2.7
Trunk fat-free mass	2.3	13.4	22.8	0.8	0.9	2.6	3.9	3.7	4.4	4.8	4.3	4.8	4.5	4.3	3.5	4.0
Ever depressed for a whole week	2.3	2.9	6.0	-0.8	0.0	0.7	1.5	0.8	2.5	1.8	2.3	2.4	1.7	2.4	2.4	1.5
Hand grip strength (right)	2.2	5.9	12.9	-1.3	-0.3	0.7	1.9	2.7	2.7	3.5	3.0	3.6	2.3	2.9	3.2	2.2
Comparative height size at age 10	2.2	12.4	23.3	1.2	0.3	2.8	4.0	4.8	4.0	4.8	3.3	4.2	4.7	3.6	3.1	3.6
Comparative body size at age 10	2.1	5.8	9.4	-0.2	-1.3	-2.2	-2.8	-2.8	-2.8	-2.6	-2.7	-2.9	-3.1	-2.9	-2.9	-1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.1	2.5	4.1	-0.9	-0.2	-1.0	-1.5	-1.7	-1.9	-1.4	-1.9	-2.0	-1.8	-2.0	-1.9	-1.8
Arm predicted mass (left)	2.1	10.5	16.3	1.0	1.2	2.8	3.6	3.1	3.8	3.9	4.0	4.0	3.9	3.8	3.1	3.6
Heel bone mineral density (BMD) T-score, automated (left)	2.0	4.5	7.5	-1.9	-1.3	-2.6	-2.7	-2.5	-2.2	-1.7	-2.1	-2.0	-2.7	-2.0	-1.7	-2.6
Headache pain in last month	2.0	3.4	5.9	-0.9	-1.2	-2.4	-2.4	-1.7	-1.9	-1.4	-2.2	-1.7	-2.0	-2.3	-1.9	-2.1
Myopia	2.0	2.8	6.7	1.9	0.5	-0.2	-1.3	-2.1	-1.9	-2.6	-1.6	-2.2	-1.6	-1.8	-2.0	-1.5
Eye problems/disorders: Diabetes related eye disease	1.9	2.1	8.0	1.3	0.1	1.4	1.7	1.5	1.4	1.1	1.3	1.3	1.6	1.3	1.1	2.8
Medication: Co-codamol	1.9	2.2	4.5	1.2	0.4	-0.1	-1.2	-1.5	-2.1	-1.6	-1.5	-2.1	-1.5	-1.8	-2.1	-1.3
Sitting height	1.9	13.6	20.6	0.5	0.8	2.2	3.9	4.2	4.5	4.5	4.2	4.5	4.5	4.3	4.2	4.3
Eye problems/disorders: None of the above	1.9	2.2	4.1	1.4	0.5	1.8	2.0	1.2	1.9	1.4	1.5	1.3	2.0	1.6	1.2	1.5
Whole body water mass	1.9	10.9	18.1	0.9	0.9	2.7	3.6	3.3	3.9	4.2	4.0	4.3	4.0	3.9	3.1	3.6
Commuting to job workplace: Public transport	1.9	2.3	17.0	4.1	0.6	2.6	1.8	-0.0	0.5	-0.5	0.9	0.4	1.3	0.5	-0.2	0.8
Arm fat-free mass (left)	1.9	9.6	15.3	0.8	1.1	2.5	3.4	3.1	3.6	3.9	3.7	3.9	3.8	3.6	3.0	3.5
Neuroticism (2016)	1.8	2.6	5.7	-0.5	-0.1	-1.2	-2.2	-2.4	-1.9	-1.9	-1.4	-1.4	-2.2	-1.8	-1.6	-1.6
Medication: Ibuprofen	1.8	2.1	4.5	1.1	-0.1	-0.0	-1.2	-1.5	-2.1	-1.9	-1.2	-1.2	-1.8	-2.0	-2.0	-1.6
Arm predicted mass (right)	1.8	9.3	14.6	0.9	0.9	2.5	3.4	3.0	3.5	3.8	3.7	3.8	3.7	3.6	3.0	3.3
Whole body fat-free mass	1.8	10.1	17.1	0.9	0.9	2.5	3.4	3.1	3.8	4.0	3.8	4.1	3.9	3.8	3.0	3.5
Basal metabolic rate	1.8	9.8	17.0	1.1	1.0	2.8	3.4	2.9	3.6	3.8	3.9	4.1	3.8	3.7	2.8	3.4
Average weekly spirits intake	1.6	2.0	5.4	0.5	0.7	0.2	-1.2	-2.3	-1.8	-1.7	-0.9	-0.8	-1.5	-1.4	-1.8	-2.3
Happiness	1.6	2.0	6.1	1.3	1.3	2.5	1.7	0.5	1.3	1.1	1.9	1.6	1.6	1.5	0.6	1.1
Ever highly irritable/argumentative for 2 days	1.6	1.9	4.5	0.7	1.1	0.3	-0.8	-1.7	-1.4	-1.5	-1.3	-1.7	-1.1	-1.4	-2.1	-2.1
Arm fat-free mass (right)	1.6	8.0	13.0	0.7	0.8	2.3	3.1	2.7	3.3	3.6	3.5	3.6	3.4	3.4	2.8	3.1
Number of full sisters	1.6	1.9	7.8	-1.3	-2.3	-2.8	-2.2	-0.4	-0.7	-0.5	-1.3	-0.4	-1.4	-0.8	-0.1	-1.5
Loneliness, isolation	1.6	2.2	9.8	3.1	2.8	2.6	0.9	-0.9	-0.4	-1.0	0.5	0.0	0.5	-0.2	-1.8	-0.3
Mineral and other dietary supplements	1.6	2.1	4.2	0.6	-1.7	-0.0	1.3	2.0	1.9	1.8	1.0	1.6	1.9	1.6	1.6	1.3
HDL Cholesterol	1.5	2.4	4.6	0.9	1.3	-0.2	-1.1	-1.5	-2.0	-2.1	-1.6	-1.9	-1.7	-1.7	-2.1	-1.8
Waist Hip Ratio (WHR)	1.5	6.7	19.9	-0.4	-1.5	0.0	1.9	4.5	3.4	3.8	1.3	2.6	3.4	2.5	3.4	2.1
Medication: Metformin	1.5	2.1	4.4	0.2	-0.1	0.9	1.3	1.4	1.5	1.8	1.8	1.9	1.5	1.7	1.7	2.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.5	2.0	7.2	0.2	1.0	0.2	-1.3	-2.7	-1.6	-1.8	-0.5	-0.5	-1.5	-1.3	-2.0	-1.9
Relative age voice broke	1.5	2.3	5.6	-1.1	0.4	0.5	1.2	1.3	2.0	2.0	1.9	2.4	1.7	1.9	2.0	0.3
Ever unenthusiastic/disinterested for a whole week	1.5	1.8	3.7	0.4	1.0	1.8	1.6	0.6	1.6	1.4	1.6	1.9	1.7	1.6	1.3	0.7
Medication: Seretide 50 evohaler	1.5	1.7	4.1	-0.7	0.9	0.7	1.0	1.3	1.4	1.6	1.8	2.0	1.4	1.5	1.3	1.4
Wears glasses or contact lenses	1.5	1.7	4.0	-0.4	-2.0	-1.2	-1.2	-1.2	-1.2	-1.1	-1.6	-1.8	-1.1	-1.4	-1.4	-1.2
Hearing difficulty/problems with background noise	1.4	2.2	4.0	0.5	0.3	-1.2	-1.8	-2.0	-1.7	-1.9	-1.3	-1.3	-1.6	-1.6	-1.9	-2.0
Suffer from ‘nerves’	1.4	2.2	6.0	-0.7	0.3	-0.3	-1.5	-2.5	-1.9	-1.8	-0.8	-0.8	-1.9	-1.7	-2.0	-1.9
Rheumatoid Arthritis	1.3	1.7	5.2	-0.4	-2.3	-2.0	-1.5	0.1	-1.1	-0.6	-1.9	-1.4	-1.0	-1.3	-0.9	-1.5
Lung FVC	1.3	6.7	12.7	0.2	1.5	0.0	-1.8	-3.5	-3.5	-3.6	-1.8	-3.1	-3.1	-3.0	-3.3	-2.8
Had other major operations	1.3	1.6	3.0	0.0	1.5	1.7	1.6	1.1	1.2	1.3	1.5	1.2	1.1	1.2	1.0	1.6
Medication for cholesterol, blood pressure or diabetes	1.3	2.2	6.6	2.4	0.0	0.7	-0.6	-1.3	-1.5	-1.6	-1.6	-1.6	-0.8	-1.8	-2.6	-1.6
Number of children fathered	1.3	1.4	3.8	-1.6	-0.4	0.3	0.7	1.8	1.2	1.9	1.1	1.3	0.9	1.1	1.6	0.9
Neck or shoulder pain in last month	1.3	1.8	3.8	-0.5	0.4	-1.3	-1.9	-1.8	-1.6	-1.3	-1.3	-1.1	-1.8	-1.5	-1.4	-1.3
Diabetes (father)	1.2	1.4	3.0	0.8	0.6	1.1	1.6	1.7	1.5	1.3	0.6	0.7	1.7	1.2	1.2	1.2
Taking other prescription medications	1.2	1.9	4.9	0.5	1.2	2.1	1.6	0.6	1.1	0.8	2.2	1.6	1.1	1.6	1.2	1.7
Commuting to job workplace: Car/motor vehicle	1.2	1.4	4.1	-2.0	-0.1	-0.7	0.5	0.8	1.4	1.5	1.2	1.4	0.9	1.6	1.7	0.2
Ever had bowel cancer screening	1.2	1.4	3.9	-0.6	-1.0	-0.5	0.3	1.4	1.3	1.4	1.2	1.5	1.0	1.5	2.0	1.1
Back pain experienced in last month	1.2	1.7	4.6	1.8	1.3	2.1	1.9	0.5	1.2	0.7	1.5	1.3	1.6	1.5	0.1	0.4
Miserableness	1.2	2.0	4.9	1.1	-0.3	-0.1	-1.3	-1.6	-1.8	-1.6	-1.5	-1.0	-1.4	-1.8	-2.2	-1.8
Eye problems/disorders: Glaucoma	1.2	1.4	3.0	-1.0	-0.5	-1.1	-1.3	-1.7	-1.3	-1.3	-0.9	-1.2	-1.4	-1.0	-1.0	-1.5
Medication: Lisinopril	1.2	1.5	3.6	-1.9	-0.2	-0.0	0.7	1.1	1.4	1.7	1.2	1.5	0.8	1.4	1.8	1.3
Schizophrenia vs Biploar Disorder	1.1	1.5	4.7	-2.2	-1.4	-1.6	-0.3	0.8	1.0	1.3	0.9	1.4	0.3	1.1	1.6	1.2
Reaction Time	1.1	2.0	5.2	0.4	1.4	0.1	-1.3	-1.0	-1.8	-1.3	-1.6	-0.7	-1.4	-1.9	-2.3	-2.2
Ovarian Cancer	1.1	1.4	3.2	-0.5	0.6	0.9	1.5	1.8	1.1	1.6	1.2	1.1	1.5	1.3	1.2	1.3
Bilateral oophorectomy (both ovaries removed)	1.1	1.2	3.1	0.2	-1.4	-0.8	-1.3	-1.5	-1.1	-1.2	-1.0	-0.9	-1.1	-1.0	-0.8	-1.8
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.6	4.4	1.1	-0.3	-0.1	-1.2	-1.7	-1.6	-1.6	-1.1	-1.0	-1.1	-1.5	-2.1	-1.5
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.2	2.8	0.2	-1.4	-1.1	-1.6	-1.7	-1.3	-1.2	-0.8	-0.6	-1.3	-1.0	-1.3	-0.2
Medication: Paracetamol	1.1	1.8	4.8	-0.7	-0.9	-0.9	-1.5	-2.2	-1.6	-1.7	-1.0	-1.2	-1.8	-1.3	-1.3	-1.4
Leg predicted mass (right)	1.1	5.8	10.7	0.7	0.6	2.2	2.6	2.2	2.8	3.0	3.0	3.3	2.8	2.8	2.2	2.5
Cholesterol lowering medication	1.1	1.7	4.7	-1.3	-2.2	-1.5	-1.4	-0.3	-1.2	-0.4	-1.7	-1.3	-1.5	-1.3	-0.7	-1.3
Smoking Status	1.0	2.4	4.5	-0.1	1.0	-0.5	-1.4	-2.0	-2.0	-2.1	-1.3	-1.9	-2.0	-1.7	-1.9	-1.2
Leg fat-free mass (left)	1.0	5.0	9.7	0.9	0.3	2.1	2.4	1.9	2.6	2.7	2.9	3.1	2.6	2.6	2.0	2.4
Weight	1.0	4.9	9.4	1.9	1.4	2.6	2.5	1.5	2.4	2.1	3.0	3.1	2.6	2.5	1.5	2.2
Birth weight of first child	1.0	1.8	3.7	0.8	-0.1	1.5	1.8	1.6	1.4	1.5	1.1	1.5	1.9	1.3	1.3	1.2
Medication: Amlodipine	1.0	1.4	5.7	1.0	2.4	0.5	-0.3	-1.6	-1.1	-1.5	-0.6	-1.3	-0.8	-0.9	-1.5	-0.9
Pulse wave peak to peak time	1.0	1.2	2.6	1.3	-0.3	1.1	1.6	0.4	1.3	0.6	1.3	0.5	1.3	1.4	1.1	1.4
Health satisfaction	1.0	1.4	3.9	-0.0	-1.7	-0.8	-1.5	-2.0	-1.3	-1.2	-0.7	-0.8	-1.4	-0.9	-1.2	-1.0
Medication: Omeprazole	1.0	1.2	2.4	0.9	0.4	1.4	1.4	0.9	1.0	0.7	1.3	0.8	1.6	1.2	1.1	1.4
Leg fat-free mass (right)	1.0	5.5	10.1	0.7	0.6	2.2	2.6	2.1	2.8	2.9	2.9	3.2	2.7	2.7	2.1	2.5
Average weekly red wine intake	1.0	1.4	3.1	-1.1	-1.2	-0.2	1.0	1.7	1.4	1.6	0.5	0.5	1.2	1.2	1.8	1.6
Medication: Blood pressure	1.0	1.9	3.3	-0.2	-0.5	-1.1	-1.6	-1.4	-1.6	-1.5	-1.7	-1.5	-1.8	-1.6	-1.3	-1.8
Pain experienced in last month	1.0	1.6	3.0	-0.2	0.4	1.2	1.7	1.7	1.3	1.5	1.3	1.0	1.4	1.4	1.6	1.4
Primary Biliary Cirrhosis	0.9	1.3	4.2	-1.8	-1.1	-2.0	-1.6	-0.4	-0.8	-0.3	-1.3	-0.6	-1.1	-1.0	-0.5	-0.9
Lung FEV1/FVC ratio	0.9	4.6	10.2	1.1	-0.1	-1.3	-1.8	-2.2	-2.3	-2.5	-2.7	-3.2	-2.1	-2.5	-2.9	-2.4
Frequency of depressed mood in last 2 weeks	0.9	1.2	3.9	1.3	0.2	0.4	-0.9	-1.6	-1.3	-1.4	-0.5	-0.2	-0.8	-1.2	-2.0	-1.3
Leg predicted mass (left)	0.9	4.9	9.6	0.9	0.3	2.0	2.4	1.9	2.6	2.7	2.8	3.1	2.6	2.6	2.0	2.3
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	5.8	-1.8	-1.2	-2.4	-1.9	-1.5	-1.2	-0.7	-1.4	-1.4	-1.7	-1.1	-0.6	-1.3
Medication: Cholesterol lowering	0.9	1.4	9.0	-3.0	-0.9	-2.4	-1.5	-0.2	-0.5	0.1	-0.1	0.2	-1.2	-0.2	0.8	-0.1
Depression (self-reported)	0.9	1.0	2.1	-1.3	-0.1	-1.0	-1.5	-1.3	-1.0	-0.9	-0.9	-0.6	-1.3	-0.9	-0.7	-1.4
Medication: Blood pressure	0.9	1.5	3.8	-0.9	0.9	0.2	1.0	0.9	1.4	1.0	1.7	1.5	1.0	1.7	1.9	1.6
Migraine (self-reported)	0.9	1.1	2.5	-1.0	-1.3	-0.6	-1.3	-0.6	-1.3	-0.6	-0.9	-0.8	-1.2	-1.3	-1.0	-1.6
Had major operations	0.9	1.1	3.1	0.3	1.3	0.0	-1.0	-1.8	-1.2	-1.6	-0.5	-0.8	-1.0	-0.9	-1.0	-1.1
Commuting to job workplace: Walk	0.9	0.9	2.0	0.2	-0.5	-0.3	-1.0	-1.4	-1.2	-1.4	-0.8	-1.2	-1.1	-1.0	-1.0	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	2.9	0.2	-0.4	0.0	-0.7	-1.7	-1.3	-1.6	-0.6	-1.1	-1.1	-1.1	-1.4	-0.6
Fractured/broken bones in last 5 years	0.9	1.2	3.3	-0.6	-1.1	-0.8	0.6	1.8	1.5	1.5	0.4	0.8	1.1	1.3	1.5	0.5
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.4	0.8	0.4	1.5	1.5	0.7	1.0	0.7	1.4	0.6	1.5	1.2	0.9	1.3
Mean Putamen Volume	0.8	0.9	5.4	0.1	-0.9	-2.3	-1.5	0.7	-0.4	0.1	-1.3	-0.4	-0.5	-1.0	-0.0	0.6
Medication for hormone replacement therapy	0.8	0.9	2.2	-1.0	-0.6	-1.2	-1.2	-1.3	-1.1	-1.1	-0.4	-0.9	-1.5	-0.6	-0.5	-0.4
Serious illness, injury or assault to yourself	0.8	0.9	1.7	0.6	-0.2	-0.5	-1.1	-1.3	-1.2	-1.3	-0.8	-1.0	-1.2	-0.9	-1.3	-1.0
Alcohol usually taken with meals	0.8	1.3	3.5	0.1	0.2	0.2	1.2	1.7	1.6	1.2	0.7	0.5	1.4	1.3	1.9	1.3
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	4.0	0.9	0.4	-0.2	-1.0	-2.0	-1.2	-1.5	-0.9	-1.1	-1.1	-1.1	-1.6	-1.4
Medication for pain relief, constipation, heartburn	0.8	1.3	3.6	0.0	0.2	0.2	1.0	1.9	1.6	1.7	0.7	1.1	1.6	1.2	1.1	1.1
Eye problems/disorders: Cataract	0.8	0.9	1.4	-0.0	-0.7	-0.8	-1.2	-0.9	-1.1	-1.1	-1.2	-1.0	-1.2	-1.0	-1.1	-1.0
High cholesterol (Self-reported)	0.8	1.4	4.5	-2.1	-2.0	-2.1	-1.3	0.7	-0.6	0.6	-1.2	-0.4	-0.9	-0.7	0.1	-0.9
Alzheimer’s Disease (in mother)	0.7	0.8	3.8	-0.7	-1.9	-1.3	-1.2	-0.4	-0.7	-0.2	-1.0	-0.4	-0.6	-0.9	-0.4	-0.8
Severe depression (siblings)	0.7	0.7	4.1	-0.8	-2.0	-1.2	-0.9	-0.5	0.2	0.1	0.4	1.0	-0.3	0.5	0.8	-0.8
Impedance of leg (right)	0.7	3.2	6.3	0.2	-0.1	0.5	1.8	2.3	2.3	1.8	1.6	1.8	2.5	2.1	2.5	2.2
Impedance of leg (left)	0.7	3.4	6.8	-0.3	0.2	0.4	1.9	2.4	2.3	2.0	1.6	1.8	2.5	2.1	2.6	2.2
Trunk fat mass	0.7	3.1	6.0	1.8	1.2	2.2	1.9	1.0	1.8	1.3	2.5	2.4	2.0	2.0	1.2	1.7
Hip circumference	0.7	3.0	9.6	3.1	2.1	2.8	1.9	-0.2	1.2	0.3	2.2	1.8	1.6	1.6	-0.1	1.5
Hair/balding pattern: Pattern 4	0.7	1.7	6.0	0.7	2.3	2.5	1.7	0.9	0.6	0.6	1.6	1.0	1.1	0.9	0.7	1.4
Mouth/teeth dental problems: Loose teeth	0.7	0.9	2.8	0.1	1.2	-0.1	-0.7	-0.8	-1.2	-0.6	-0.9	-1.0	-0.9	-1.2	-1.7	-0.7
Chest pain or discomfort	0.7	1.1	2.7	-0.9	1.6	0.7	1.1	0.7	1.0	1.2	1.4	0.7	0.8	1.2	0.8	1.3
Medication: Bendroflumethiazide	0.7	1.0	2.6	-1.6	-0.0	-1.6	-1.2	-0.3	-0.8	-0.4	-1.2	-1.0	-1.0	-0.8	-0.3	-1.6
Medication: Atorvastatin	0.7	0.9	2.1	-0.4	1.0	0.6	0.9	1.4	0.8	1.3	1.0	1.1	0.9	1.0	1.1	0.5
Age started oral contraceptive pill	0.7	0.9	1.5	0.5	0.6	0.9	1.2	1.1	0.9	0.9	1.0	0.7	1.1	1.1	1.0	1.2
Alcohol drinker status: Previous	0.7	0.8	2.5	-1.6	-1.3	-0.4	0.2	0.0	1.0	0.8	0.9	1.1	0.4	1.2	1.3	-0.2
Alzheimer’s Disease (including proxy)	0.6	0.9	1.8	-0.3	-1.2	-1.1	-1.2	-1.2	-1.0	-1.0	-0.9	-0.4	-1.0	-0.8	-0.8	-1.3
LDL Cholesterol	0.6	0.9	3.0	0.8	0.3	0.7	1.0	1.7	1.2	0.9	0.8	1.0	1.2	0.8	1.1	0.9
Relative age of first facial hair	0.6	1.2	2.5	-0.2	0.3	0.4	1.3	1.5	1.6	1.4	1.0	1.2	1.4	1.4	1.3	0.8
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.7	0.5	0.8	0.2	-0.8	-1.2	-1.2	-0.9	-0.8	-1.0	-0.9	-1.1	-1.3	-1.0
Ever used hormone-replacement therapy (HRT)	0.6	0.8	2.7	1.5	-0.3	0.5	-0.1	-1.6	-0.9	-1.6	0.2	-0.8	-0.8	-0.3	-0.9	0.5
Age when periods started (menarche)	0.6	1.5	3.6	0.0	0.7	1.0	1.3	1.3	1.2	1.2	1.3	1.4	1.1	1.4	1.6	1.9
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	4.1	1.0	2.0	0.8	0.1	-1.0	-0.6	-0.8	0.0	-0.6	-0.2	-0.5	-1.0	-0.4
Medication: Levothyroxine sodium	0.6	1.0	2.7	0.3	0.5	1.1	0.9	0.5	1.1	0.8	1.6	1.6	1.0	1.3	1.0	1.0
Hair/balding pattern: Pattern 2	0.6	0.7	2.3	0.4	0.4	0.5	1.0	0.8	1.1	1.0	0.8	1.5	1.0	0.7	0.4	1.0
Pain all over the body in last month	0.6	0.6	4.7	2.2	0.4	0.9	-0.1	-0.9	-0.1	-0.9	0.1	0.3	0.2	-0.1	-0.6	-0.7
Time employed in main current job	0.6	0.7	4.0	2.0	0.4	1.0	0.1	-1.5	-0.6	-1.3	0.2	-0.0	-0.0	-0.3	-0.9	-0.2
Pulse rate	0.6	1.1	2.4	-0.1	-0.7	-1.1	-1.5	-1.2	-1.2	-1.0	-0.9	-0.6	-1.2	-1.2	-0.9	-1.5
Prospective memory result	0.6	0.7	1.3	-0.7	-1.0	-1.0	-1.1	-1.0	-1.1	-0.8	-0.5	-0.3	-1.1	-0.9	-0.6	-0.6
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	2.0	0.5	-1.1	-0.6	-0.9	-0.8	-0.8	-0.9	-1.0	-0.9	-0.8	-0.8	-0.8	-1.4
Exposure to tobacco smoke outside home	0.6	0.9	6.8	2.6	1.1	1.0	0.5	-0.8	-0.1	-1.2	0.5	-0.2	-0.0	0.1	-0.6	0.1
Whole body fat mass	0.6	2.5	4.9	1.9	1.5	2.2	1.7	0.5	1.5	0.9	2.2	2.1	1.7	1.7	0.8	1.4
Overall health rating	0.6	1.2	2.3	1.1	-1.2	-0.8	-1.4	-1.2	-1.2	-1.5	-1.1	-0.8	-1.1	-1.0	-1.3	-0.9
Asthma (self-reported)	0.6	1.3	3.7	-0.9	0.4	0.6	0.9	0.9	1.3	1.3	1.5	1.9	0.8	1.4	1.3	1.0
Medication: Gliclazide	0.6	0.7	2.1	-0.4	0.9	0.1	-0.8	-0.8	-1.4	-0.6	-0.8	-0.3	-1.1	-1.4	-1.1	-0.6
Smoking status: Current	0.6	0.9	2.2	0.5	1.0	0.2	-0.2	-1.5	-1.0	-1.4	-0.7	-1.4	-0.9	-0.7	-1.4	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	3.4	0.7	1.4	0.6	-0.4	-1.3	-1.2	-1.3	-0.8	-0.9	-0.8	-1.2	-1.8	-1.5
Average weekly beer plus cider intake	0.6	0.9	2.4	-0.5	0.4	-0.2	0.7	0.8	1.2	1.0	1.3	1.3	0.8	1.5	1.2	0.7
Crohns Disease (2017)	0.5	1.1	5.5	1.0	2.3	2.2	1.1	0.1	0.0	0.3	1.1	0.9	0.6	0.1	0.3	0.4
Crohns Disease (2012)	0.5	0.8	1.9	0.6	1.3	1.3	-0.3	-1.4	-1.2	-0.9	-0.0	-0.5	-0.7	-1.0	-1.0	-1.1
BMI	0.5	3.0	9.5	0.6	1.2	0.1	-1.5	-3.1	-2.2	-2.3	-0.5	-1.1	-2.3	-1.6	-2.3	-1.9
Number of treatments/medications taken	0.5	0.9	3.7	-0.2	1.1	0.3	-0.7	-1.9	-1.2	-1.7	0.4	-0.2	-1.4	-0.5	-0.6	-0.1
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	3.9	1.4	2.0	1.3	0.5	-0.7	-0.2	-0.7	0.3	-0.3	-0.1	0.1	-0.5	0.0
Body mass index (BMI)	0.5	2.2	5.8	2.0	1.4	1.1	-0.7	-2.4	-1.7	-2.1	-0.3	-0.9	-1.4	-1.2	-2.3	-1.1
Waist circumference	0.5	2.0	3.7	1.9	1.0	1.8	1.6	1.1	1.5	1.2	1.5	1.8	1.8	1.5	0.7	1.2
Number of incorrect matches in round	0.5	0.8	2.3	-1.4	-0.9	-1.5	-1.1	0.4	-0.6	-0.0	-1.2	-0.8	-1.0	-0.8	-0.1	-0.7
Medication: Ventolin 100micrograms inhaler	0.5	0.7	2.3	-1.5	-0.5	-0.1	0.1	0.5	0.6	0.9	1.1	1.4	0.2	0.8	1.0	0.1
Emphysema/chronic bronchitis	0.5	0.6	1.4	-0.5	-1.2	-0.7	-0.1	1.0	0.5	1.2	0.4	1.2	0.5	0.5	0.6	0.9
Alcohol intake frequency.	0.5	1.1	2.2	1.2	-1.2	0.8	1.1	0.1	1.3	0.5	1.2	1.1	1.5	1.4	1.2	0.8
Family relationship satisfaction	0.5	0.7	1.7	1.0	1.1	1.3	1.1	0.6	0.8	0.6	0.7	0.6	1.0	0.9	-0.1	-0.0
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.3	-0.9	0.8	-0.9	-0.8	0.2	-0.8	-0.4	-1.1	-0.7	-0.6	-1.1	-0.9	-0.6
Mood swings	0.5	1.0	3.1	0.4	0.6	1.6	1.2	0.2	0.9	0.7	1.5	1.8	1.2	1.1	0.3	0.1
Osteoporosis (self-reported)	0.5	0.6	2.6	-0.5	-1.6	-0.7	-0.5	0.8	-0.7	-0.1	-1.0	-0.9	-0.4	-0.8	0.1	-0.9
Financial situation satisfaction	0.5	0.6	2.5	0.6	0.9	1.6	0.8	0.1	0.3	0.4	1.2	1.2	0.6	0.8	0.4	0.3
Supplements: Calcium	0.5	0.5	2.7	-0.2	1.6	1.0	0.1	-0.3	-0.7	-0.6	-0.5	-0.9	-0.4	-0.9	-0.7	-0.3
Schizophrenia (2018)	0.4	0.8	3.5	-1.5	-1.9	-1.7	-0.9	0.3	-0.1	0.3	-0.5	0.1	-0.6	-0.0	0.7	-0.3
Irritable Bowel Disease (IBD)	0.4	0.9	3.4	0.2	1.3	1.9	1.3	0.1	0.5	0.7	1.6	0.9	0.7	0.7	0.9	0.8
Fasting Glucose	0.4	0.4	1.7	-1.3	-0.9	-0.7	-0.1	0.7	0.7	0.8	0.1	0.8	0.3	0.5	0.8	-0.0
Blood Eosinophil Count	0.4	3.0	5.7	-1.5	-0.0	-1.9	-2.4	-1.4	-1.8	-1.1	-2.1	-1.5	-2.2	-1.9	-1.7	-2.3
Neuroticism	0.4	0.9	5.9	0.5	2.4	1.4	0.1	-0.7	-0.8	-0.7	0.2	0.1	-0.3	-0.6	-1.2	-0.9
Supplements: Zinc	0.4	0.4	3.6	0.4	1.9	0.7	0.5	0.5	0.0	-0.0	-0.3	-0.8	0.1	-0.2	-0.3	-0.4
Pack years adult smoking proportion	0.4	0.6	2.3	-0.1	0.2	1.0	0.9	0.8	0.4	0.8	1.1	0.8	0.3	0.6	0.6	1.5
Current tobacco smoking	0.4	0.7	1.6	0.2	1.0	0.2	-0.2	-1.3	-0.8	-1.2	-0.5	-1.2	-0.9	-0.6	-1.1	-0.3
Average weekly fortified wine intake	0.4	0.4	1.2	0.5	-0.3	0.4	0.6	0.2	0.9	0.3	0.9	1.1	1.0	1.0	0.5	-0.6
Hayfever, allergic rhinitis or eczema	0.4	0.9	2.0	-0.8	0.9	-0.5	-1.2	-1.1	-1.1	-0.8	-0.8	-0.6	-1.4	-0.9	-0.9	-1.1
Chronic bronchitis/emphysema (father)	0.4	0.4	2.8	0.0	1.7	1.4	0.5	-0.1	-0.2	-0.1	0.7	0.4	0.1	0.1	-0.2	0.5
Nervous feelings	0.4	0.8	2.2	-0.5	0.2	0.1	-0.8	-0.9	-1.5	-1.1	-0.7	-0.7	-1.3	-1.3	-1.1	-0.8
Neuroticism score	0.4	0.9	2.8	0.3	1.1	0.6	-0.6	-1.0	-1.3	-0.9	-0.3	-0.1	-0.8	-1.1	-1.7	-1.2
Alcohol intake versus 10 years previously	0.4	0.6	3.9	2.0	-0.7	1.3	0.7	0.1	0.4	-0.1	0.7	0.5	0.8	0.5	-0.6	0.4
Falls in the last year	0.4	0.6	1.9	1.2	1.1	0.1	-0.2	-1.4	-0.2	-1.3	-0.2	-0.9	-0.2	-0.1	-0.8	-0.4
Hair/balding pattern: Pattern 3	0.4	0.6	2.1	0.1	-0.0	-0.4	-0.7	-1.4	-0.7	-1.1	-0.8	-0.9	-0.9	-0.7	-1.0	-1.0
Mouth/teeth dental problems: Dentures	0.4	0.7	4.5	0.2	2.1	1.5	0.4	-1.0	-0.4	-0.8	0.9	0.3	-0.2	0.1	-0.3	-0.3
Lung cancer (father)	0.4	0.5	1.1	0.8	-0.1	0.3	0.7	-0.1	1.1	0.0	1.0	0.9	0.6	1.1	1.0	0.8
Pulse wave Arterial Stiffness index	0.4	0.5	2.2	-1.5	0.2	-1.0	-1.1	0.3	-0.6	0.2	-0.7	0.3	-0.6	-0.7	-0.3	-0.7
Length of working week for main job	0.4	0.4	1.3	0.8	1.0	1.1	0.8	-0.0	0.4	0.2	0.8	0.6	0.6	0.6	0.1	0.1
Tense / ‘highly strung’	0.4	0.7	2.4	-1.6	0.4	-1.0	-1.2	-0.1	-0.9	-0.0	-0.7	-0.2	-0.8	-0.9	-0.7	-1.3
Loud music exposure frequency	0.4	0.4	1.9	-1.4	-0.7	-0.9	-0.7	-1.1	-0.0	-0.4	0.1	0.0	-0.5	-0.0	0.2	-0.7
Glaucoma (self-reported)	0.4	0.5	1.2	-0.5	0.1	-0.5	-0.7	-1.1	-0.7	-1.0	-0.5	-1.1	-1.0	-0.6	-0.3	-0.8
Mean time to correctly identify matches	0.4	0.7	2.2	-0.1	1.2	0.1	-0.8	-0.5	-1.0	-0.6	-0.9	-0.3	-0.7	-0.9	-1.2	-1.5
Leg fat mass (right)	0.4	1.5	4.7	2.1	1.5	2.2	1.2	-0.3	0.6	0.1	1.6	1.3	1.0	0.9	-0.1	1.0
Age at last live birth	0.4	0.5	1.3	-0.0	-0.4	0.7	1.0	0.4	1.0	0.7	0.8	1.1	1.1	1.1	0.4	0.2
Illnesses of siblings: Diabetes	0.4	0.5	1.3	-0.4	-1.1	-0.8	-1.1	-0.1	-0.7	-0.4	-0.9	-0.2	-0.7	-0.8	-0.3	-0.6
Illnesses of father: None of the above (group 1)	0.4	0.4	2.2	-0.6	-0.6	-1.2	-0.3	1.5	0.2	0.9	0.1	0.3	0.2	0.2	0.8	-0.1
Number of operations (self-reported)	0.4	0.7	1.8	-0.0	0.0	0.2	0.6	0.2	1.1	0.7	1.2	1.2	0.8	1.2	1.3	0.7
Impedance of whole body	0.4	1.9	4.9	-0.7	-0.7	-0.1	1.1	2.1	1.8	1.5	0.9	1.4	1.8	1.5	2.2	1.3
Leg fat mass (left)	0.4	1.6	4.9	2.0	1.6	2.2	1.4	-0.2	0.8	0.3	1.8	1.4	1.1	1.0	0.0	1.1
Depressed Affect (Nagel 2018)	0.3	0.7	3.0	1.6	1.2	1.7	0.6	-0.5	-0.2	-0.4	0.5	0.6	0.4	-0.1	-0.8	-0.8
Ulcerative Colitis (UC)	0.3	0.6	1.7	-0.7	-0.2	0.8	1.0	0.0	0.8	0.7	1.2	0.4	0.7	1.0	1.3	0.9
Body Mass Index (BMI) (2010)	0.3	0.4	1.2	0.3	0.1	0.3	-0.3	-0.7	-0.8	-0.7	-0.7	-0.7	-0.5	-0.9	-1.1	-0.9
Coronary Artery Disease (CAD)	0.3	0.3	2.6	-0.5	-1.6	-0.7	-0.3	0.2	0.1	-0.1	-0.3	-0.2	-0.1	0.2	0.7	0.3
Lupus	0.3	0.5	1.6	-1.1	-0.6	-1.3	-0.7	0.7	-0.3	0.7	-1.1	-0.5	-0.3	-0.7	-0.2	-0.1
Schizophrenia (2014)	0.3	0.6	2.0	-1.2	-1.3	-1.4	-1.0	-0.1	-0.4	-0.2	-0.4	-0.0	-0.7	-0.3	0.2	-0.8
Allergy or Eczema	0.3	0.7	1.6	-0.9	0.4	-1.0	-1.3	-0.6	-0.9	-0.4	-0.8	-0.4	-1.2	-0.8	-0.5	-1.0
Cardiovascular Disease	0.3	0.9	2.1	-0.3	-1.4	-1.4	-1.4	-1.1	-0.9	-1.0	-0.5	-0.2	-1.1	-0.7	-0.3	-1.1
Chronotype (morning person)	0.3	0.6	1.7	-0.4	0.4	-0.1	-0.6	-0.6	-1.2	-0.7	-1.0	-1.0	-1.1	-1.3	-0.9	-0.6
Angina	0.3	0.4	1.3	0.1	0.3	0.9	0.8	0.1	0.5	0.4	1.0	0.5	0.3	0.8	0.7	1.1
Vitamin and mineral supplements	0.3	0.4	2.0	1.4	0.5	0.6	0.7	0.4	0.3	0.4	0.4	0.8	0.8	0.5	-0.4	0.3
Trunk fat percentage	0.3	1.1	2.9	1.7	1.1	1.6	1.0	-0.0	0.8	0.1	1.5	1.3	0.9	1.0	0.3	0.7
Townsend deprivation index at recruitment	0.3	0.4	3.0	1.7	0.7	0.8	0.5	0.2	0.3	-0.2	0.4	0.1	0.4	0.3	0.0	1.1
Qualifications: CSEs or equivalent	0.3	0.4	1.8	-0.1	-0.1	-0.3	-0.5	-1.4	-0.7	-0.7	-0.2	-0.4	-0.7	-0.5	-1.0	-0.5
Multivitamins +/- minerals	0.3	0.4	4.0	-2.0	-0.1	-0.0	-0.2	0.0	0.3	0.6	0.5	0.6	-0.3	0.2	0.9	-0.0
Stomach or abdominal pain in last month	0.3	0.4	2.5	-1.6	0.9	-0.4	-0.3	-0.3	-0.6	-0.2	-0.5	-0.8	-0.8	-0.4	-0.3	-0.2
Supplements: Glucosamine	0.3	0.4	1.0	-0.9	1.0	0.6	-0.1	-0.8	-0.7	-0.4	-0.1	-0.6	-0.7	-0.4	-0.5	-0.3
Medication: Atenolol	0.3	0.3	1.9	1.4	0.1	0.7	0.7	-0.6	0.2	-0.9	0.3	-0.5	0.1	0.4	-0.1	0.5
Had menopause	0.3	0.4	1.0	0.6	0.5	0.0	-0.4	-0.8	-1.0	-1.0	-0.2	-0.7	-0.7	-0.6	-0.7	0.1
Forced vital capacity (FVC)	0.3	1.3	3.1	-0.2	0.1	1.4	1.3	0.7	1.2	1.5	1.5	1.7	1.4	1.2	1.0	0.9
Mouth/teeth dental problems	0.3	0.5	1.4	-0.6	-1.2	-1.2	-0.2	0.7	0.7	0.7	-0.1	0.4	0.3	0.4	0.9	0.7
Allergy	0.3	0.7	1.6	1.3	-0.0	1.2	1.2	0.4	0.9	0.2	0.9	0.4	1.2	0.9	0.6	0.6
Hayfever/allergic rhinitis (self-reported)	0.3	0.3	1.7	-1.3	0.3	0.3	0.4	0.6	0.4	0.7	0.6	0.2	0.1	0.6	0.9	0.4
Illnesses of siblings	0.3	0.4	3.2	-1.8	-0.2	-0.9	-0.5	0.2	-0.1	0.5	-0.7	-0.1	-0.3	-0.4	0.2	-0.7
Impedance of arm (right)	0.3	1.2	2.7	-0.4	-0.5	-0.1	0.9	1.6	1.6	1.2	0.6	1.2	1.5	1.2	1.6	1.1
Worrier / anxious feelings	0.3	0.6	1.2	-1.1	-0.5	-1.0	-1.0	-1.1	-0.7	-0.7	-0.5	-0.3	-1.1	-0.6	-0.6	-1.1
Noisy workplace	0.3	0.3	1.0	-0.6	0.6	0.7	0.4	0.4	0.3	0.8	0.7	1.0	0.3	0.4	0.3	0.3
Asthma	0.3	0.5	2.2	-0.8	0.7	0.5	0.5	0.4	0.7	0.7	1.0	1.5	0.3	0.9	0.7	0.5
Arm fat mass (right)	0.3	1.2	4.4	2.1	1.3	2.0	1.1	-0.3	0.6	0.1	1.3	1.1	0.9	0.8	-0.4	0.6
Breastfed as a baby	0.3	0.4	2.1	0.8	1.4	1.1	0.6	-0.7	0.1	-0.3	0.4	0.4	0.2	0.2	-0.1	0.3
Pulse wave reflection index	0.3	0.4	2.8	0.2	1.7	1.3	0.6	-0.3	-0.5	-0.4	0.2	-0.4	-0.2	-0.2	-0.4	0.2
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.8	-1.3	-0.8	-0.2	-0.1	1.2	0.3	1.2	-0.4	0.5	0.2	-0.0	0.7	0.5
Gout (self-reported)	0.3	0.4	3.6	1.9	0.7	0.3	0.2	0.3	0.1	-0.3	-0.1	0.0	0.4	0.1	-0.4	0.6
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.9	0.5	1.1	1.2	0.4	-0.6	0.2	-0.2	1.4	1.1	0.1	0.6	0.4	0.4
Forced vital capacity (FVC), Best measure	0.3	1.2	2.5	-0.2	0.5	1.2	1.3	1.1	1.3	1.6	1.2	1.3	1.5	1.1	1.1	1.0
Leg fat percentage (right)	0.3	1.0	3.9	2.0	1.3	1.2	-0.1	-1.5	-0.8	-1.4	0.2	-0.3	-0.5	-0.5	-1.4	-0.3
Worry too long after embarrassment	0.3	0.5	2.1	-1.4	-0.7	-1.0	-1.0	-0.2	-0.6	0.1	-0.2	0.2	-0.7	-0.5	-0.5	-0.8
Angina (self-reported)	0.3	0.4	1.2	0.1	0.5	0.9	0.8	-0.1	0.5	0.2	1.0	0.5	0.2	0.8	0.6	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	1.1	0.2	-0.8	0.1	0.4	0.5	0.5	0.5	0.6	0.6	0.6	0.5	0.8	1.1
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.8	1.3	0.6	1.0	0.8	-0.3	0.3	-0.7	0.7	0.1	0.3	0.6	-0.2	0.0
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	2.0	-1.4	-0.3	-1.0	-0.2	0.8	0.5	0.6	-0.4	0.0	0.2	0.0	0.6	-0.8
Illnesses of father: Heart disease	0.3	0.4	1.4	0.2	-0.6	0.5	-0.3	-1.2	-0.7	-0.8	-0.4	-0.5	-0.6	-0.7	-1.1	-0.5
Long-standing illness, disability or infirmity	0.3	0.4	4.4	0.3	2.1	0.4	-0.1	-0.5	-0.4	-0.5	0.3	-0.1	-0.3	0.0	-0.4	0.3
Friendships satisfaction	0.3	0.4	1.9	-0.3	0.4	0.6	-0.3	-0.9	-0.5	-0.0	-0.3	-0.0	-0.3	-0.5	-1.2	-1.4
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	1.7	0.2	0.5	0.1	-0.4	-0.6	-0.9	-0.4	-0.6	-0.5	-0.5	-0.9	-1.3	-0.8
Breast cancer (self-reported)	0.3	0.3	2.7	0.3	-1.7	-0.3	0.1	0.4	0.4	0.2	0.2	0.4	0.1	0.6	0.9	0.3
Arm fat mass (left)	0.3	1.2	4.6	2.1	1.5	2.0	1.0	-0.3	0.5	0.1	1.3	1.2	0.8	0.8	-0.4	0.6
Average weekly champagne plus white wine intake	0.3	0.4	3.6	1.9	0.8	0.3	-0.1	0.1	-0.2	-0.5	-0.7	-0.2	0.3	-0.6	-0.6	-0.5
Ever taken oral contraceptive pill	0.3	0.4	1.0	-0.7	0.1	-0.8	-0.6	-0.7	-0.5	-0.7	-0.4	-0.7	-1.0	-0.6	-0.4	0.1
Tinnitus: Yes, now most or all of the time	0.3	0.4	2.1	-1.1	1.4	0.7	0.2	0.0	0.1	0.5	0.5	0.7	-0.0	0.4	0.0	-0.6
Medication: Paracetamol	0.3	0.5	1.3	-0.6	-0.8	-0.7	-0.7	-1.1	-0.7	-0.9	-0.2	-0.5	-0.9	-0.5	-0.2	-0.8
Ever smoked	0.3	0.5	1.1	0.0	0.5	-0.1	-0.4	-0.6	-0.8	-0.8	-0.9	-1.0	-0.6	-0.7	-0.9	-0.9
Ever had prostate specific antigen (PSA) test	0.3	0.4	1.7	-1.3	0.4	-0.7	-0.6	-0.2	0.3	0.4	0.4	1.0	0.0	0.3	0.9	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.7	1.3	-0.3	-0.4	-0.4	-0.1	-0.5	-0.6	-0.7	-1.1	-0.1	-0.7	-0.6	-0.0
Intelligence (Savage-Jansen 2018)	0.2	0.6	3.5	0.6	-0.2	-0.2	0.8	1.9	0.9	0.9	-0.1	0.0	1.0	0.7	0.6	0.7
Worry (Nagel 2018)	0.2	0.5	1.0	-0.8	0.9	0.2	-0.5	-0.7	-1.0	-0.7	-0.2	-0.0	-1.0	-0.8	-0.9	-1.0
Alzheimer’s Disease (in father)	0.2	0.2	1.3	0.0	0.5	-0.3	-0.5	-1.1	-0.3	-0.8	0.2	0.3	-0.6	0.2	-0.2	-0.5
Verbal and Numeric Reasoning (VNR)	0.2	0.4	2.5	1.6	0.2	0.7	0.6	1.0	0.3	0.1	-0.5	-0.5	0.7	-0.0	-0.0	-0.4
Breast Cancer	0.2	0.5	2.3	0.5	1.5	0.8	1.0	1.0	0.5	0.5	0.2	0.3	0.8	0.3	0.2	0.7
Prostate Cancer	0.2	0.3	1.4	1.1	1.2	0.5	-0.1	-0.7	-0.3	-0.5	0.1	0.2	-0.1	-0.3	-0.5	0.1
Type 2 Diabetes (T2D) (2012)	0.2	0.3	0.8	0.4	0.2	0.5	0.8	0.6	0.7	0.5	0.4	0.1	0.9	0.6	0.3	0.3
Ulcerative Colitis	0.2	0.3	1.2	-0.0	-0.2	1.1	0.9	-0.1	0.2	0.3	0.9	-0.0	0.4	0.5	0.6	0.7
Heel T-Score	0.2	1.7	12.0	-3.5	-0.6	-2.1	-1.8	-0.5	-0.5	0.6	-0.1	0.3	-1.3	-0.3	0.4	-1.3
Systolic Blood Pressure	0.2	1.2	2.8	0.9	-1.0	0.5	1.2	0.7	1.4	0.8	1.3	1.4	1.2	1.4	1.0	1.7
Hypothyroidism (self reported)	0.2	0.4	1.5	0.7	0.8	1.0	-0.1	-1.2	-0.7	-1.0	0.7	0.4	-0.5	-0.2	-0.6	0.0
Respiratory disease	0.2	0.5	2.1	-1.4	0.2	-0.2	0.2	0.4	0.5	0.9	0.7	1.0	0.1	0.6	0.6	1.1
Diabetes (mother)	0.2	0.3	1.4	-0.9	-0.9	-1.2	-0.6	0.1	0.1	0.2	-0.5	0.2	-0.2	-0.1	0.1	-0.3
Fed-up feelings	0.2	0.3	1.5	1.2	-0.1	0.6	-0.1	-0.7	-0.4	-0.7	0.1	-0.1	-0.1	-0.2	-0.8	-0.5
Past tobacco smoking	0.2	0.3	1.4	0.2	-1.2	0.0	0.5	0.6	0.7	0.6	0.4	0.4	0.6	0.5	0.5	0.8
Financial difficulties in last 2 years	0.2	0.3	0.9	1.0	0.8	0.8	0.5	-0.2	0.3	0.1	0.8	0.5	0.4	0.5	0.2	0.7
Medication: Ramipril	0.2	0.3	0.8	-0.2	-0.9	-0.6	-0.7	-0.7	-0.5	-0.6	-0.3	-0.4	-0.8	-0.4	-0.2	-0.3
Fluid intelligence score	0.2	0.4	2.2	1.5	0.5	0.5	0.7	1.2	0.3	0.3	-0.5	-0.6	0.8	-0.1	-0.1	0.1
Arm fat percentage (right)	0.2	0.9	3.4	1.8	1.2	1.2	-0.1	-1.4	-0.5	-1.2	0.2	0.0	-0.4	-0.3	-1.3	-0.5
Number of live births	0.2	0.3	1.7	-1.3	-0.3	-0.6	-0.1	1.1	0.3	1.0	-0.2	0.4	0.2	0.2	0.4	-0.4
Impedance of arm (left)	0.2	1.1	2.3	-0.1	-0.5	0.2	1.0	1.4	1.5	1.0	0.6	1.2	1.5	1.2	1.5	0.6
Exposure to tobacco smoke at home	0.2	0.3	1.4	0.3	-0.3	-0.3	0.0	0.1	0.4	-0.1	0.9	1.2	0.3	0.7	0.8	0.4
Peak expiratory flow (PEF)	0.2	0.5	1.6	-0.6	0.8	1.0	0.5	0.0	0.5	0.8	0.9	1.2	0.5	0.7	0.1	-0.4
Blood clot in the leg (DVT)	0.2	0.3	1.2	1.1	-0.6	-0.5	-0.3	0.2	-0.3	-0.3	-0.6	-0.9	0.0	-0.6	-0.5	0.1
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.5	0.5	-0.3	0.7	0.4	0.0	0.6	0.1	0.7	0.7	0.6	0.7	0.3	0.7
Body fat percentage	0.2	0.8	2.8	1.7	1.3	1.5	0.8	-0.4	0.4	-0.2	1.1	0.9	0.6	0.6	-0.1	0.5
Number of full brothers	0.2	0.3	1.0	0.3	0.3	0.5	-0.1	0.7	-0.6	0.0	-0.6	-0.4	-0.3	-0.7	-1.0	-0.2
Qualifications: College or University degree	0.2	0.7	2.5	0.3	-0.4	0.6	1.1	1.6	1.1	1.0	-0.0	0.3	1.5	0.6	0.9	0.0
Medication: Allopurinol	0.2	0.2	1.6	1.3	0.6	0.1	-0.2	-0.2	-0.4	-0.6	0.2	0.2	-0.3	-0.1	-0.4	0.3
Heart disease (mother)	0.2	0.3	1.4	1.2	-0.6	0.5	0.5	-0.3	0.5	-0.3	0.6	0.2	0.6	0.6	0.3	0.4
Medication: Aspirin	0.2	0.2	0.8	0.6	0.4	-0.5	-0.5	-0.6	-0.5	-0.9	-0.3	-0.3	-0.7	-0.3	-0.2	0.0
Arm fat percentage (left)	0.2	1.0	3.8	2.0	1.1	1.4	-0.0	-1.5	-0.6	-1.3	0.3	0.0	-0.4	-0.4	-1.4	-0.6
Qualifications: nursing, teaching	0.2	0.2	1.5	-0.9	-1.2	-0.4	-0.2	-0.0	0.1	0.7	-0.5	0.1	-0.2	-0.0	-0.1	0.4
Osteoarthritis (self-reported)	0.2	0.3	1.0	-0.6	0.2	-0.4	-0.5	1.0	-0.3	0.5	-0.7	-0.2	-0.1	-0.4	0.1	-1.0
Medication: Aspirin	0.2	0.3	0.9	0.6	-0.3	-0.6	-0.7	-0.6	-0.5	-1.0	-0.5	-0.4	-0.6	-0.3	-0.2	-0.0
Number of self-reported non-cancer illnesses	0.2	0.3	2.4	-1.5	-0.2	-0.5	-0.4	0.1	-0.0	0.4	0.6	0.7	-0.5	0.3	0.6	0.2
Guilty feelings	0.2	0.3	1.0	1.0	-0.5	1.0	0.2	-0.9	-0.3	-0.6	0.7	0.3	-0.0	-0.0	-0.6	-0.2
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.8	-0.9	0.3	-0.5	-0.7	-0.2	-0.8	-0.2	-0.6	-0.6	-0.8	-0.8	0.0	-0.0
Illnesses of father: High blood pressure	0.2	0.3	1.0	0.5	-0.7	0.7	-0.0	-1.0	-0.2	-0.6	-0.4	-0.3	-0.2	-0.4	-0.9	-0.3
Leg fat percentage (left)	0.2	0.8	2.6	1.6	1.4	1.1	-0.0	-1.3	-0.7	-1.2	0.3	-0.2	-0.4	-0.4	-1.2	-0.1
Heart disease (siblings)	0.2	0.3	0.9	0.8	0.2	-0.5	-0.3	-0.5	-0.6	-0.9	-0.3	-0.6	-0.7	-0.3	-0.5	0.4
Pack years of smoking	0.2	0.4	1.2	-0.1	0.6	0.9	0.6	0.4	0.2	0.5	1.0	0.7	-0.0	0.4	0.4	1.1
Bipolar Disorder (2018)	0.1	0.2	1.3	0.2	1.1	0.9	0.4	-0.0	-0.1	-0.1	0.0	-0.0	0.1	-0.1	-0.4	-0.3
Bipolar Disorder or Schizophrenia	0.1	0.2	1.1	-1.1	-0.8	-0.8	-0.5	0.3	-0.1	0.2	-0.4	0.0	-0.4	-0.1	0.3	-0.4
Neuroticism (Nagel 2018)	0.1	0.2	0.7	-0.4	0.6	0.9	0.2	-0.1	-0.3	-0.0	0.5	0.6	-0.0	-0.1	-0.3	-0.8
Major Depression (MDD)	0.1	0.1	0.3	0.4	-0.5	0.4	0.2	-0.3	0.1	-0.1	0.1	0.5	0.1	0.2	-0.3	0.0
Age at First Birth	0.1	0.1	0.4	0.3	0.5	0.5	0.3	-0.4	-0.1	-0.1	-0.1	-0.3	0.1	-0.2	-0.6	-0.2
Bipolar Disorder (2011)	0.1	0.1	1.0	-1.0	0.0	-0.4	-0.3	-0.0	-0.1	0.3	-0.2	0.2	-0.3	-0.2	-0.3	-0.5
Blood Platelet Count	0.1	1.7	4.6	-0.4	-1.2	-1.6	-1.6	-0.4	-1.1	-0.6	-2.1	-1.5	-1.2	-1.6	-1.4	-1.5
Blood Red Count	0.1	0.8	1.8	-0.8	-0.3	-1.1	-1.0	0.0	-1.1	-0.5	-1.2	-0.7	-1.1	-1.4	-0.8	-0.9
Blood White Count	0.1	0.6	1.6	1.3	0.5	1.1	1.1	0.9	0.7	0.7	0.4	0.3	1.0	0.6	0.1	0.8
Hair Pigment	0.1	3.7	7.5	-0.4	-0.4	0.9	1.9	2.7	2.3	2.5	1.6	2.1	2.2	2.4	2.4	2.3
Sensitivity / hurt feelings	0.1	0.2	0.5	-0.7	-0.5	-0.5	-0.5	0.1	-0.5	-0.0	-0.3	-0.3	-0.2	-0.5	-0.4	-0.4
Maternal smoking around birth	0.1	0.1	0.4	-0.0	-0.2	-0.3	-0.5	-0.7	-0.3	-0.3	0.3	0.1	-0.5	-0.0	0.1	0.1
High blood pressure (mother)	0.1	0.1	0.6	0.2	0.4	0.2	-0.2	-0.8	-0.4	-0.5	0.3	-0.2	-0.4	-0.1	-0.3	-0.3
Qualifications: None of the above	0.1	0.3	1.2	1.1	0.5	0.9	0.6	-0.6	0.0	-0.4	0.7	0.0	0.3	0.3	-0.2	0.5
Heart attack	0.1	0.1	0.6	-0.6	0.8	0.0	0.2	0.6	0.0	0.5	-0.2	-0.4	-0.0	0.0	0.4	0.4
Diabetes (self-reported)	0.1	0.2	0.9	0.3	0.1	0.3	0.1	-0.2	0.2	0.2	0.6	0.9	0.2	0.4	0.4	0.6
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	1.2	0.2	0.0	1.1	0.8	-0.0	0.5	0.7	0.7	0.9	0.7	0.4	-0.0	0.1
Qualifications: A levels/AS levels or equivalent	0.1	0.3	1.5	0.6	0.2	0.4	0.4	1.2	0.3	0.8	-0.7	0.3	0.7	-0.2	-0.2	0.2
Medication: Lansoprazole	0.1	0.1	0.5	-0.4	-0.3	-0.2	-0.0	-0.5	0.2	0.0	0.6	0.3	0.1	0.6	0.7	-0.1
Illnesses of mother	0.1	0.1	0.3	-0.3	0.4	-0.3	-0.2	0.6	-0.1	0.3	-0.3	-0.2	-0.1	-0.2	-0.2	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	1.3	0.7	0.9	1.2	1.0	0.2	0.6	0.5	0.5	0.4	0.9	0.4	0.0	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.4	0.6	0.1	0.6	0.2	-0.5	-0.0	-0.3	0.4	0.4	0.1	0.3	-0.1	-0.2
Birth weight	0.1	0.2	0.6	0.5	0.8	0.6	0.5	0.1	0.3	0.4	0.3	0.3	0.4	0.3	-0.3	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.6	0.5	-0.5	-0.1	-0.2	-0.7	-0.0	-0.8	0.4	0.2	-0.0	0.2	0.2	-0.4
Wheeze or whistling in the chest in last year	0.1	0.1	0.4	-0.2	0.1	-0.0	-0.5	-0.4	-0.6	-0.0	0.1	0.4	-0.6	-0.2	-0.7	0.1
Age at first live birth	0.1	0.2	1.3	0.2	-1.1	-0.5	-0.3	-0.5	-0.1	-0.4	-0.1	0.0	-0.0	0.0	-0.0	-0.5
Shortness of breath walking on level ground	0.1	0.1	0.4	0.1	0.6	0.3	0.1	0.3	-0.3	0.2	-0.0	0.1	-0.1	-0.1	-0.2	-0.3
Pulse rate, automated reading	0.1	0.3	0.9	0.5	-0.8	-0.1	0.0	0.7	0.5	0.6	0.3	0.9	0.6	0.3	0.6	0.3
Knee pain experienced in last month	0.1	0.2	0.7	0.6	-0.8	-0.5	0.1	0.2	0.6	0.3	0.0	0.0	0.6	0.5	0.4	0.7
Hypertension (Self-reported)	0.1	0.1	0.5	-0.3	0.1	-0.7	-0.2	-0.4	0.3	-0.3	0.4	0.4	-0.1	0.5	0.7	0.1
Smoking status: Previous	0.1	0.2	1.1	-0.4	1.1	-0.0	-0.5	-0.1	-0.5	-0.2	-0.1	0.3	-0.4	-0.2	-0.1	-0.7
Diabetes diagnosed by doctor	0.1	0.2	0.8	-0.1	-0.4	-0.1	0.0	0.1	0.4	0.4	0.6	0.9	0.2	0.6	0.7	0.9
Alcohol drinker status: Never	0.1	0.1	0.5	0.7	0.1	-0.1	0.3	-0.3	0.6	0.0	0.1	0.2	0.4	0.4	0.1	0.5
Irritability	0.1	0.1	0.5	-0.2	0.1	0.4	-0.2	0.2	-0.5	0.1	-0.2	-0.2	-0.2	-0.5	-0.2	-0.7
Diastolic blood pressure, automated reading	0.1	0.3	0.9	0.2	-1.0	-0.5	-0.4	-0.3	-0.4	-0.3	-0.6	-0.7	-0.6	-0.7	-0.7	0.3
Unable to work because of sickness or disability	0.1	0.1	0.7	0.5	-0.1	0.4	-0.1	-0.8	0.1	-0.4	0.2	0.2	0.1	0.2	-0.3	-0.3
Commuting to job workplace: Cycle	0.1	0.1	1.0	1.0	0.3	0.1	-0.1	-0.3	0.0	-0.3	-0.1	-0.0	-0.0	-0.0	-0.2	0.4
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.6	-0.5	0.6	0.1	0.4	0.8	0.3	0.6	-0.0	-0.3	0.2	0.2	0.5	0.6
Type 2 Diabetes (T2D) (2018)	0.0	0.0	0.3	0.2	-0.5	-0.2	-0.1	-0.0	0.2	-0.0	-0.1	0.1	-0.1	0.2	0.3	0.1
Tanning	0.0	0.4	2.7	-0.9	1.6	0.6	-0.1	-0.5	-0.6	-0.0	0.7	0.5	-0.6	-0.2	-0.1	0.6
Systolic blood pressure, automated reading	0.0	0.1	0.2	0.4	-0.5	0.1	0.3	-0.5	0.3	-0.0	0.4	0.1	0.0	0.3	-0.1	0.4
High blood pressure	0.0	0.1	0.6	-0.2	-0.1	-0.8	-0.3	-0.2	0.0	-0.3	0.3	0.4	-0.2	0.3	0.6	0.0
Father’s age at death	0.0	0.0	0.3	0.0	0.6	-0.1	0.0	0.2	-0.2	-0.2	-0.2	-0.1	-0.3	-0.2	-0.1	-0.1
High blood pressure (siblings)	0.0	0.1	0.3	0.5	0.1	0.1	-0.0	-0.3	-0.2	-0.5	0.3	-0.1	-0.3	0.0	-0.1	0.3
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.4	0.1	-0.3	0.3	0.1	0.2	0.0	0.3	-0.5	-0.3	0.2	-0.3	-0.6	-0.4

Hub : Genes

ADAM28

Models

Trait associations