Hub : Genes

PPP2R2A

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 METSIM Adipose 0.0563 0.0196 0.0012 0.001 0.007 -0.001 0.006 0.013 0.240 2.9e-02 0.59000 0.035 0.00380
2 TCGA Breast Invasive Carcinoma 0.0381 0.0167 0.0080 0.000 0.005 -0.001 NA -0.001 0.340 2.8e-02 0.57000 NA 0.82000
3 TCGA Thyroid Carcinoma 0.1260 0.0380 0.0004 0.013 0.047 0.030 NA 0.028 0.019 2.3e-05 0.00054 NA 0.00093

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 3.0 4.8 12.1 0.5 -3.5 1.4
Bipolar Disorder or Schizophrenia 2.0 4.8 8.8 -0.5 -2.3 3.0
Depressed Affect (Nagel 2018) 0.5 1.2 1.8 -1.3 0.8 -1.1
Depression (Nagel 2018) 0.8 1.2 1.4 -1.0 1.2 -1.1
Intelligence (Savage-Jansen 2018) 1.4 4.2 8.7 1.8 -0.8 2.9
Neuroticism (Nagel 2018) 1.2 2.9 7.0 -2.6 -0.1 -1.3
Schizophrenia (2018) 1.3 2.7 7.0 -1.1 -0.1 2.6
Schizophrenia vs Biploar Disorder 0.4 0.5 1.4 0.3 1.2 0.1
Worry (Nagel 2018) 1.0 2.1 5.9 -2.4 -0.3 -0.5
Alzheimer’s Disease (in mother) 1.6 1.8 4.2 0.2 -1.1 2.1
Alzheimer’s Disease (in father) 0.8 0.8 1.6 -0.1 -1.3 0.9
Alzheimer’s Disease (including proxy) 3.2 4.6 7.7 0.5 -2.4 2.8
Crohns Disease (2017) 1.2 2.5 6.8 0.2 -2.6 -0.9
Irritable Bowel Disease (IBD) 2.1 4.9 14.2 -0.2 -3.8 -0.7
Ulcerative Colitis (UC) 2.1 3.9 11.4 -0.5 -3.4 -0.2
Major Depression (MDD) 0.1 0.1 0.4 0.7 -0.1 0.0
Reaction Time 0.5 0.9 2.1 1.5 -0.7 -0.3
Verbal and Numeric Reasoning (VNR) 0.9 2.3 3.3 1.8 -1.0 1.6
Breast Cancer 0.3 0.7 1.5 -0.5 1.2 -0.5
Ovarian Cancer 1.6 2.1 3.7 -1.4 0.8 -1.9
Prostate Cancer 0.4 0.6 1.4 -0.1 0.7 1.2
Age at First Birth 1.4 2.0 4.5 -0.3 2.1 1.2
Bipolar Disorder (2011) 0.8 0.8 1.3 1.1 -1.0 -0.2
Body Mass Index (BMI) (2010) 0.6 0.8 1.7 -0.1 0.8 1.3
Coronary Artery Disease (CAD) 1.6 2.0 3.7 -1.9 1.0 -1.1
Crohns Disease (2012) 1.3 2.0 4.5 0.4 -2.1 -1.2
Mean Putamen Volume 0.9 1.0 2.9 -0.2 -0.2 1.7
Fasting Glucose 0.0 0.1 0.2 -0.0 -0.4 -0.1
HbA1C 1.3 1.5 3.4 -0.7 -1.9 0.7
HDL Cholesterol 0.5 0.9 1.1 -1.1 1.1 -0.6
LDL Cholesterol 0.5 0.8 1.4 0.2 -1.2 1.0
Lupus 0.7 1.1 3.1 -0.5 1.8 -0.2
Neuroticism (2016) 1.1 1.6 3.3 -1.2 -0.1 -1.8
Primary Biliary Cirrhosis 0.5 0.7 1.8 1.4 0.2 -0.4
Rheumatoid Arthritis 0.2 0.2 0.4 -0.6 0.2 0.6
Schizophrenia (2014) 1.1 2.4 6.7 -0.2 -0.7 2.6
Triglycerides 0.3 0.5 0.9 0.3 -1.0 -0.6
Type 2 Diabetes (T2D) (2012) 0.2 0.2 0.4 0.7 -0.5 -0.1
Ulcerative Colitis 2.2 3.3 9.4 -0.6 -3.1 0.2
Blood Eosinophil Count 0.1 0.4 0.7 -0.5 0.6 -0.9
Blood Platelet Count 0.1 0.6 1.2 0.7 -1.1 -0.2
Blood Red Count 0.4 4.1 8.6 1.8 0.7 2.9
Blood White Count 0.5 4.0 10.6 -0.4 1.1 -3.2
Heel T-Score 1.2 9.7 14.1 -2.2 -3.8 -3.1
BMI 0.5 3.1 7.1 -1.3 0.7 -2.7
Height 1.0 20.1 46.4 3.2 1.9 6.8
Waist Hip Ratio (WHR) 0.7 3.2 5.3 1.3 -1.7 2.3
Systolic Blood Pressure 2.3 11.7 17.3 -3.8 1.7 -4.2
Smoking Status 0.7 1.6 2.9 -1.0 1.0 -1.7
Allergy or Eczema 0.9 2.4 4.8 -0.4 -2.2 1.5
Cardiovascular Disease 2.6 8.7 14.6 -3.1 1.4 -3.8
Hypothyroidism (self reported) 0.6 1.3 2.2 -1.0 -0.8 -1.5
Respiratory disease 0.6 1.3 2.5 -1.1 1.6 0.1
Type 2 Diabetes (T2D) (2018) 0.2 0.4 0.7 -0.8 -0.6 0.6
Lung FEV1/FVC ratio 0.4 1.8 4.7 0.8 0.3 2.2
Lung FVC 0.2 1.2 2.4 0.3 -1.0 -1.6
Neuroticism 2.1 5.0 11.0 -3.3 0.8 -1.9
Chronotype (morning person) 0.3 0.6 1.5 1.2 0.6 -0.2
Hair Pigment 0.0 0.8 1.7 -0.4 1.3 -0.8
Tanning 0.0 0.3 0.5 0.6 -0.3 -0.7
Hand grip strength (left) 0.5 1.3 2.5 0.8 -0.9 1.6
Number of treatments/medications taken 1.8 3.3 5.2 -2.1 0.5 -2.3
Average weekly spirits intake 0.3 0.3 0.9 -1.0 -0.2 -0.2
Sensitivity / hurt feelings 0.6 1.0 2.4 -0.7 -0.3 -1.6
Frequency of depressed mood in last 2 weeks 1.9 2.7 4.4 0.3 1.9 -2.1
Hearing difficulty/problems: Yes 0.1 0.2 0.4 0.7 -0.1 0.1
Relative age of first facial hair 0.6 1.2 2.1 1.3 1.4 0.2
Other serious medical condition/disability diagnosed by doctor 2.0 2.6 4.9 -2.2 -1.7 -0.3
Ever used hormone-replacement therapy (HRT) 0.4 0.5 1.0 -0.4 -0.7 1.0
Ever had hysterectomy (womb removed) 2.7 3.1 6.7 -2.6 0.3 -1.6
Systolic blood pressure, automated reading 1.3 3.8 4.5 -2.0 1.7 -2.1
Eye problems/disorders: Diabetes related eye disease 0.7 0.8 1.6 0.3 1.3 -0.8
Angina 1.8 2.4 4.0 -1.5 2.0 -0.9
Medication for hormone replacement therapy 1.2 1.3 1.4 -1.2 -1.1 -1.2
Vitamin and mineral supplements 0.6 0.9 2.1 1.5 -0.4 -0.6
Supplements: Zinc 0.2 0.2 0.7 -0.8 -0.2 -0.1
Medication: Co-codamol 0.5 0.6 1.2 -0.2 -1.1 -0.8
Medication: Metformin 0.4 0.5 1.0 -0.2 -1.0 0.7
Diabetes (father) 1.4 1.7 2.9 1.7 -0.6 -1.4
Diabetes (mother) 1.2 1.6 3.0 1.7 -0.0 -1.3
Severe depression (siblings) 0.5 0.5 1.1 0.5 -1.1 -0.4
Pack years adult smoking proportion 1.6 2.5 4.8 -1.4 0.7 -2.2
Impedance of leg (right) 0.6 2.8 8.1 -0.4 2.8 0.4
Leg fat-free mass (left) 0.0 0.1 0.2 0.4 -0.1 0.3
Trunk fat percentage 0.8 3.3 7.1 -1.5 2.7 -0.8
Hand grip strength (right) 0.5 1.4 1.5 1.0 -1.2 1.2
Townsend deprivation index at recruitment 3.0 4.2 7.8 -1.4 2.8 -1.7
Current tobacco smoking 0.5 0.8 1.2 0.1 1.1 -1.1
Average weekly fortified wine intake 0.6 0.7 1.3 -0.1 -0.9 -1.1
Maternal smoking around birth 0.4 0.6 1.7 1.3 -0.1 0.2
Fed-up feelings 1.0 1.8 2.8 -1.0 1.3 -1.7
Frequency of unenthusiasm / disinterest in last 2 weeks 1.1 1.5 3.6 -0.7 0.7 -1.9
Relative age voice broke 0.6 1.0 2.4 -0.4 1.6 -0.6
Taking other prescription medications 1.0 1.5 3.4 -1.1 0.1 -1.8
Age when periods started (menarche) 0.6 1.5 3.2 -0.5 1.8 1.0
Bilateral oophorectomy (both ovaries removed) 1.8 2.0 4.4 -2.1 0.9 -0.9
Heel bone mineral density (BMD) T-score, automated (left) 1.3 2.9 4.0 -1.1 -2.0 -1.8
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 0.7 0.8 0.2 -0.7
Qualifications: CSEs or equivalent 0.3 0.4 0.9 -0.4 0.2 -1.0
Serious illness, injury or assault to yourself 1.1 1.4 3.4 -1.8 0.4 -0.7
High blood pressure 1.7 4.6 11.5 -1.3 0.7 -3.4
Hayfever, allergic rhinitis or eczema 0.6 1.3 2.2 0.1 -1.5 1.3
Multivitamins +/- minerals 0.2 0.2 0.4 -0.6 -0.2 0.4
Stomach or abdominal pain in last month 0.2 0.2 0.3 -0.3 -0.4 0.6
Supplements: Glucosamine 1.5 1.9 4.1 2.0 -0.8 1.0
Diverticular disease/diverticulitis (self-reported) 1.4 1.6 3.3 -1.0 -0.7 -1.8
Medication: Atenolol 2.7 3.4 4.9 -1.7 1.5 -2.2
Medication: Levothyroxine sodium 0.8 1.4 3.3 0.7 0.5 -1.8
Sitting height 0.7 4.8 7.7 2.4 0.9 2.8
Chronic bronchitis/emphysema (father) 0.7 0.8 1.9 0.1 -0.7 -1.4
High blood pressure (mother) 0.0 0.0 0.1 0.3 0.0 0.0
Body mass index (BMI) 1.0 4.1 9.6 -1.4 0.9 -3.1
Impedance of leg (left) 0.7 3.4 8.7 0.2 3.0 1.2
Leg predicted mass (left) 0.0 0.1 0.2 0.4 -0.0 0.3
Trunk fat mass 0.4 1.8 5.0 -0.6 2.2 -0.2
Waist circumference 0.1 0.2 0.4 0.4 0.4 -0.6
Number of incorrect matches in round 2.6 4.2 7.1 2.7 -2.1 1.2
Past tobacco smoking 0.8 1.4 2.1 1.5 -1.0 1.1
Alcohol usually taken with meals 2.5 4.1 8.0 1.8 -1.0 2.8
Nervous feelings 0.5 1.0 2.4 -1.5 0.7 -0.1
Frequency of tenseness / restlessness in last 2 weeks 1.7 2.6 6.4 -0.5 1.1 -2.5
Hearing difficulty/problems with background noise 0.6 1.0 1.4 -0.7 1.0 -1.2
Hair/balding pattern: Pattern 2 0.5 0.6 1.0 0.6 -0.6 1.0
Had menopause 0.5 0.6 1.2 0.8 1.1 0.4
Had other major operations 2.9 3.5 9.4 -0.9 0.6 -3.1
Forced vital capacity (FVC) 0.7 2.8 4.5 2.1 -1.5 1.3
Heel bone mineral density (BMD) T-score, automated (right) 1.2 2.7 4.1 -1.2 -2.0 -1.6
Ever unenthusiastic/disinterested for a whole week 1.2 1.4 2.5 -0.2 1.6 -1.3
Qualifications: None of the above 1.6 3.4 8.0 -1.5 0.0 -2.8
Financial difficulties in last 2 years 1.8 2.4 3.1 -1.3 1.8 -1.6
Mouth/teeth dental problems 0.5 0.8 1.8 -0.1 -1.4 -0.8
Heart attack 3.9 5.0 9.1 -1.9 3.0 -1.5
Allergy 0.3 0.7 2.2 1.5 0.1 0.1
Pain all over the body in last month 1.0 1.1 2.9 -0.5 0.3 -1.7
Diabetes (self-reported) 0.1 0.2 0.3 -0.4 -0.6 0.2
Hayfever/allergic rhinitis (self-reported) 0.2 0.3 0.6 -0.8 0.4 0.3
Medication: Ramipril 0.3 0.4 1.0 0.2 1.0 -0.4
Medication: Simvastatin 0.5 0.7 1.6 -0.6 0.4 -1.3
Fluid intelligence score 0.5 1.0 2.1 -0.9 -0.5 1.4
Illnesses of siblings 1.2 1.7 2.6 0.5 -1.5 1.6
Neuroticism score 0.7 1.4 3.0 -1.7 0.9 -0.8
Weight 0.1 0.3 0.8 0.1 0.9 -0.5
Impedance of arm (right) 0.3 1.2 2.3 -1.1 0.5 1.5
Arm fat percentage (right) 0.9 3.5 4.8 -2.2 1.2 -2.1
Trunk fat-free mass 0.3 1.6 2.5 1.4 -0.5 1.6
Hip circumference 0.4 1.9 2.2 -1.5 1.3 -1.3
Time employed in main current job 0.3 0.3 0.7 0.3 -0.3 0.9
Alcohol intake versus 10 years previously 0.4 0.6 1.2 0.2 -0.8 -1.1
Father’s age at death 5.3 7.0 15.2 1.3 -2.1 3.9
Worrier / anxious feelings 0.6 1.1 2.8 -1.7 -0.6 0.4
Frequency of tiredness / lethargy in last 2 weeks 0.9 1.4 2.9 -1.1 0.3 -1.7
Falls in the last year 0.6 0.8 1.5 0.2 1.2 -0.9
Hair/balding pattern: Pattern 3 0.8 1.2 2.0 -1.2 0.4 -1.4
Number of live births 0.2 0.3 0.5 -0.7 -0.4 -0.6
Forced expiratory volume in 1-second (FEV1) 0.7 2.4 4.4 2.1 -0.8 1.5
Pulse rate 0.2 0.4 0.6 -0.8 -0.4 0.6
Happiness 0.8 1.0 1.8 1.3 1.1 0.2
Noisy workplace 3.0 3.7 10.2 0.8 -0.1 -3.2
Qualifications: A levels/AS levels or equivalent 2.4 5.2 9.7 1.0 -3.1 2.2
Serious illness, injury or assault of a close relative in last 2 years 1.0 1.1 3.3 -0.1 -1.8 0.0
Mouth/teeth dental problems: Dentures 0.8 1.3 2.1 1.0 0.9 -1.5
Asthma 1.2 2.4 5.6 -1.2 2.4 -0.5
Medication: Ibuprofen (e.g. Nurofen) 1.9 2.4 4.4 0.9 -2.1 1.4
Medication: Cholesterol lowering 2.7 4.2 5.3 -2.3 1.7 -2.1
Depression (self-reported) 0.4 0.5 1.3 -0.4 -1.1 0.3
Medication: Lansoprazole 0.3 0.3 0.6 0.2 0.8 0.6
Prospective memory result 0.0 0.0 0.1 0.0 -0.1 -0.3
Lung cancer (father) 0.8 0.9 1.8 1.3 0.4 0.9
Illnesses of mother 0.9 1.2 2.0 -1.4 1.2 -0.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.5 2.3 1.4 -0.5 1.5
Pulse wave Arterial Stiffness index 0.6 0.8 1.7 1.3 0.8 -0.0
Impedance of arm (left) 0.3 1.3 2.7 -0.6 0.9 1.6
Arm fat mass (right) 0.4 1.8 2.3 -1.4 1.1 -1.5
Trunk predicted mass 0.3 1.6 2.8 1.4 -0.4 1.7
Standing height 1.3 12.6 30.1 2.7 0.3 5.5
Length of working week for main job 1.9 2.1 2.8 1.2 -1.7 -1.5
Exposure to tobacco smoke at home 0.4 0.5 1.1 -1.1 -0.5 0.3
Breastfed as a baby 0.3 0.3 0.5 0.6 -0.7 0.3
Tense / ‘highly strung’ 0.5 0.8 2.3 -1.5 -0.2 -0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 1.2 1.8 4.1 -1.1 -2.0 -0.1
Hair/balding pattern: Pattern 4 0.2 0.4 1.1 0.4 0.0 -1.0
Birth weight of first child 2.1 3.8 9.3 1.4 0.2 3.0
Peak expiratory flow (PEF) 0.2 0.5 1.2 0.5 1.1 0.3
Pulse wave reflection index 2.9 3.6 8.0 -0.6 2.8 -1.5
Ever highly irritable/argumentative for 2 days 2.0 2.4 5.8 -1.2 0.2 -2.4
Loud music exposure frequency 0.9 1.0 1.7 -1.3 -0.4 1.0
Qualifications: O levels/GCSEs or equivalent 2.1 3.3 5.3 1.1 -2.3 1.8
Mouth/teeth dental problems: Bleeding gums 0.1 0.2 0.3 -0.2 0.5 0.5
Blood clot in the leg (DVT) 2.9 3.8 7.8 -1.5 1.1 -2.8
Medication: Paracetamol 1.0 1.7 3.1 -0.7 -1.2 -1.8
Headache pain in last month 0.8 1.3 2.0 -1.0 -1.0 1.4
Medication for cholesterol, blood pressure or diabetes 3.5 5.8 7.7 2.8 -2.5 1.9
Glaucoma (self-reported) 1.4 1.7 2.5 -0.2 -1.6 1.6
Gout (self-reported) 0.8 1.0 3.0 0.2 0.2 -1.7
Hypothyroidism/myxoedema (self-reported) 0.4 0.7 2.2 -0.0 0.0 -1.5
Medication: Amlodipine 1.5 2.2 2.3 -1.5 1.4 -1.5
Medication: Ventolin 100micrograms inhaler 0.2 0.2 0.6 0.0 0.1 -0.8
Birth weight 1.3 2.9 7.5 2.7 0.4 1.1
Chronic bronchitis/emphysema (mother) 0.1 0.2 0.5 0.2 0.0 0.7
High blood pressure (siblings) 1.4 2.1 4.2 -1.1 0.9 -2.1
Forced vital capacity (FVC), Best measure 0.3 0.9 1.6 1.3 -0.6 1.0
Body fat percentage 1.2 4.7 8.5 -1.6 2.9 -1.7
Leg fat percentage (right) 2.3 8.4 12.4 -1.3 3.5 -3.3
Arm fat-free mass (right) 0.3 1.5 1.8 1.3 0.9 1.3
Exposure to tobacco smoke outside home 3.1 4.2 9.3 -1.4 1.2 -3.0
Comparative body size at age 10 0.5 1.5 1.9 1.4 -0.9 -1.3
Number of full brothers 0.7 0.9 1.7 0.3 -1.0 -1.3
Worry too long after embarrassment 0.5 0.8 1.0 -1.0 0.6 -1.0
Seen a psychiatrist for nerves, anxiety, tension or depression 1.4 1.8 5.1 -0.5 -2.3 0.2
Wheeze or whistling in the chest in last year 1.0 1.8 4.6 -0.9 2.1 -0.4
Number of children fathered 2.0 2.3 3.6 1.2 -1.3 1.9
Reason for reducing amount of alcohol drunk: Health precaution 1.5 1.7 4.6 -0.7 -2.1 0.2
Age at first live birth 1.4 2.6 4.2 1.7 -0.7 2.0
Pulse wave peak to peak time 0.5 0.6 0.9 -0.9 -0.7 0.5
Health satisfaction 0.7 0.9 2.2 -1.5 -0.5 0.4
Shortness of breath walking on level ground 0.9 1.0 1.7 -0.9 0.8 -1.3
Qualifications: College or University degree 2.6 8.2 17.8 1.3 -2.3 4.2
Eye problems/disorders: None of the above 0.2 0.2 0.5 0.7 0.2 -0.2
Mouth/teeth dental problems: Loose teeth 1.7 2.0 3.6 -1.9 0.9 -1.3
Emphysema/chronic bronchitis 1.2 1.4 2.0 -1.4 -0.7 -1.3
Medication for pain relief, constipation, heartburn 3.0 5.1 10.4 2.2 0.5 3.2
Neck or shoulder pain in last month 0.0 0.0 0.1 -0.2 0.1 -0.3
Medication: Blood pressure 3.9 6.9 10.0 -3.2 2.0 -2.6
Angina (self-reported) 1.6 2.1 2.9 -1.5 1.7 -1.1
Migraine (self-reported) 0.7 0.8 1.7 -0.8 0.3 -1.3
Medication: Ibuprofen 1.8 2.1 3.5 0.7 -1.9 1.5
Medication: Allopurinol 0.7 0.9 2.7 0.1 -0.1 -1.6
Medication: Omeprazole 2.6 3.1 6.5 -1.5 0.9 -2.5
Medication: Seretide 50 evohaler 0.4 0.4 0.5 -0.7 -0.5 -0.7
Mean time to correctly identify matches 0.7 1.4 3.4 1.8 -0.7 0.5
Heart disease (mother) 1.9 2.3 5.5 -0.1 1.1 -2.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.1 0.3 0.2 -0.6 -0.2
Whole body fat mass 0.5 2.2 5.3 -0.6 2.3 -0.9
Leg fat mass (right) 0.8 3.3 6.4 -0.4 2.5 -1.8
Arm predicted mass (right) 0.2 1.1 1.4 1.2 0.8 1.2
Pulse rate, automated reading 0.0 0.1 0.1 0.1 -0.2 -0.3
Alcohol intake frequency. 0.1 0.2 0.5 -0.0 0.7 -0.3
Comparative height size at age 10 1.9 10.4 20.3 3.2 -0.8 4.5
Number of full sisters 0.5 0.6 1.3 0.6 -1.1 0.4
Suffer from ‘nerves’ 0.8 1.2 2.4 -1.6 0.0 -1.2
Overall health rating 3.9 8.5 16.1 -2.6 1.6 -4.0
Chest pain or discomfort 0.7 1.0 2.4 -1.6 0.7 0.2
Had major operations 1.8 2.1 4.8 -1.1 -2.2 -0.5
Age at last live birth 3.6 5.2 6.5 1.8 -2.6 2.4
Family relationship satisfaction 0.7 0.8 1.3 0.9 -1.1 0.5
Leg pain on walking 0.1 0.2 0.3 0.4 0.1 -0.5
Qualifications: NVQ or HND or HNC or equivalent 1.0 1.2 2.5 0.8 1.6 -0.5
Commuting to job workplace: Car/motor vehicle 1.7 2.0 3.0 1.7 -1.4 -0.9
Illness, injury, bereavement, stress in last 2 years 1.2 1.5 2.3 1.5 -1.0 1.1
Medication: Aspirin 3.5 4.6 7.2 -2.7 1.4 -2.2
Supplements: Vitamin C 1.4 1.7 4.1 -2.0 0.4 -0.8
Knee pain experienced in last month 0.8 1.3 2.4 -1.6 -0.9 -0.8
Hypertension (Self-reported) 1.8 5.1 11.2 -1.7 1.2 -3.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.4 1.1 -1.0 -0.5 0.2
Illnesses of father: Heart disease 0.5 0.8 1.2 -1.1 1.0 -0.4
Illnesses of siblings: Diabetes 1.0 1.2 3.0 1.7 0.6 0.4
Smoking status: Previous 0.4 0.5 1.3 -1.1 0.5 -0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.4 3.5 -0.4 0.7 1.9
Whole body fat-free mass 0.2 1.0 1.7 1.1 -0.3 1.3
Leg fat-free mass (right) 0.1 0.5 0.8 0.7 -0.3 0.9
Arm fat percentage (left) 0.9 3.8 4.8 -1.9 1.7 -2.2
Average weekly red wine intake 1.5 2.2 4.9 -1.1 -0.5 2.2
Handedness (chirality/laterality): Left-handed 1.4 1.7 3.3 -0.2 -1.4 1.8
Mood swings 0.4 0.7 1.5 -1.2 0.8 0.1
Loneliness, isolation 0.4 0.6 1.1 0.8 1.0 -0.1
Long-standing illness, disability or infirmity 0.9 1.4 2.7 -1.2 -0.2 -1.6
Ever had bowel cancer screening 1.8 2.2 3.6 -1.0 -1.4 1.9
Diabetes diagnosed by doctor 0.1 0.1 0.4 -0.6 0.1 -0.1
Ever had stillbirth, spontaneous miscarriage or termination 1.1 1.2 2.3 1.1 0.1 -1.5
Friendships satisfaction 0.6 0.7 1.8 0.5 -0.2 1.3
Qualifications: nursing, teaching 0.7 1.0 2.9 0.3 -1.7 0.4
Commuting to job workplace: Walk 0.7 0.7 2.2 -0.1 -0.1 1.5
Eye problems/disorders: Cataract 0.3 0.3 0.5 -0.6 -0.2 -0.7
Mouth/teeth dental problems: Mouth ulcers 1.0 1.6 4.7 0.1 0.3 2.2
Medication for cholesterol 1.7 2.6 6.5 1.1 0.1 2.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.4 2.9 4.4 -2.0 0.3 -2.1
Back pain experienced in last month 0.1 0.1 0.3 -0.6 0.2 0.0
Mineral and other dietary supplements 1.1 1.4 2.2 -0.4 1.4 -1.5
Breast cancer (self-reported) 0.7 0.9 2.1 1.5 0.7 0.3
Asthma (self-reported) 1.2 2.5 5.8 -1.0 2.4 -0.8
Osteoporosis (self-reported) 1.4 1.8 3.2 1.8 -1.4 0.6
Osteoarthritis (self-reported) 0.9 1.2 3.1 0.4 -1.8 -0.6
Medication: Aspirin 2.6 3.4 5.4 -2.3 1.5 -1.6
Medication: Gliclazide 0.4 0.5 1.2 0.3 0.5 -1.1
Illnesses of father: None of the above (group 1) 0.6 0.8 1.9 1.4 0.7 0.1
Smoking status: Current 0.7 1.1 2.2 -0.0 1.1 -1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.0 0.0 0.1 0.0 0.2 -0.2
Whole body water mass 0.2 1.0 1.6 1.1 -0.4 1.3
Leg predicted mass (right) 0.1 0.5 0.8 0.8 -0.4 0.9
Arm fat mass (left) 0.4 1.7 1.9 -1.2 1.4 -1.3
Number of self-reported non-cancer illnesses 0.4 0.8 1.2 -1.1 -0.3 -1.0
Average weekly champagne plus white wine intake 0.3 0.4 1.1 0.0 0.1 1.0
Miserableness 0.6 1.1 2.9 -1.7 -0.6 -0.0
Guilty feelings 0.3 0.5 1.0 -1.0 0.3 -0.6
Wears glasses or contact lenses 1.1 1.3 1.8 -1.1 1.3 1.0
Ever taken oral contraceptive pill 0.8 0.9 1.3 -1.2 -0.3 1.1
Hearing aid user 3.8 4.3 12.0 3.5 -0.7 0.7
Mother’s age at death 2.4 2.9 6.3 2.5 -0.8 1.4
Financial situation satisfaction 0.0 0.0 0.0 -0.0 -0.1 0.0
Tinnitus: Yes, now most or all of the time 0.4 0.5 1.4 -0.4 0.1 -1.2
Commuting to job workplace: Public transport 0.1 0.1 0.3 -0.5 -0.3 -0.0
Eye problems/disorders: Glaucoma 1.7 2.0 5.4 0.5 -0.4 2.3
Medication: Blood pressure 1.0 1.9 5.6 -0.2 0.0 -2.4
Pain type(s) experienced in last month: Hip pain 0.2 0.3 0.7 0.8 -0.0 -0.3
Supplements: Fish oil (including cod liver oil) 0.5 0.7 0.9 -0.9 -0.7 -0.9
High cholesterol (Self-reported) 0.4 0.7 1.3 -0.3 0.9 -1.1
Medication: Bendroflumethiazide 1.4 2.2 6.5 -0.0 0.2 -2.5
Medication: Paracetamol 1.1 1.7 3.1 -1.1 -0.8 -1.8
Medication: Lisinopril 0.8 1.1 2.2 -0.9 0.3 -1.5
Medication: Atorvastatin 1.6 2.0 2.9 -1.7 0.5 -1.7
Illnesses of father: High blood pressure 0.7 0.8 2.3 -0.5 -1.5 -0.1
Alcohol drinker status: Never 0.6 0.7 1.9 -1.4 0.5 -0.0
Ever smoked 0.3 0.5 0.9 -1.0 -0.1 -0.6
Basal metabolic rate 0.1 0.4 0.6 0.8 -0.0 0.7
Leg fat percentage (left) 1.8 6.7 11.5 -1.0 3.4 -2.8
Arm fat-free mass (left) 0.1 0.6 1.4 0.7 0.2 1.2
Number of operations (self-reported) 2.8 4.1 5.5 -2.1 -1.6 -2.3
Average weekly beer plus cider intake 3.2 4.6 9.0 -1.3 1.8 -3.0
Irritability 0.5 0.8 2.1 -1.4 -0.4 -0.2
Risk taking 0.2 0.3 0.5 -0.0 -0.7 -0.5
Ever had prostate specific antigen (PSA) test 1.6 1.8 3.0 0.1 -1.7 1.5
Fractured/broken bones in last 5 years 0.1 0.1 0.2 0.4 -0.3 -0.2
Age started oral contraceptive pill 1.1 1.4 2.6 1.6 -0.3 1.3
Diastolic blood pressure, automated reading 5.9 18.1 23.0 -4.3 3.6 -4.8
Ever depressed for a whole week 0.5 0.6 1.0 -0.1 0.9 -1.0
Unable to work because of sickness or disability 4.3 5.6 12.4 -1.7 1.1 -3.5
Commuting to job workplace: Cycle 0.4 0.5 1.3 -0.4 0.3 1.2
Myopia 0.6 0.9 2.4 -0.1 0.6 1.6
Vascular/heart problems diagnosed by doctor 1.7 4.5 9.1 1.7 -1.2 3.0
Cholesterol lowering medication 0.9 1.3 2.2 0.7 -1.0 -1.5
Medication: Omeprazole (e.g. Zanprol) 1.4 1.7 4.5 -0.8 0.1 -2.1
Pain experienced in last month 0.2 0.4 0.5 0.7 0.3 0.7
Supplements: Calcium 0.9 1.0 1.6 -1.1 -0.4 1.3
Basal cell carcinoma (self-reported) 1.5 1.8 2.7 1.6 0.3 1.6
Heart attack/myocardial infarction (self-reported) 4.6 5.9 10.4 -2.1 3.2 -1.7
Deep venous thrombosis (DVT) (self-reported) 3.1 3.9 8.1 -1.7 1.0 -2.8
Heart disease (siblings) 1.1 1.4 2.1 -0.8 1.2 -1.5
Alcohol drinker status: Previous 0.5 0.5 1.0 -1.0 -0.1 -0.8
Pack years of smoking 1.2 1.8 3.9 -1.1 0.6 -2.0
Impedance of whole body 0.5 2.5 4.1 -0.5 2.0 1.8
Leg fat mass (left) 0.7 2.9 6.1 -0.2 2.5 -1.6
Arm predicted mass (left) 0.1 0.5 0.9 0.8 0.1 0.9