TWAS hub - PPP2R2A

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0563	0.0196	0.0012	0.001	0.007	-0.001	0.006	0.013	0.240	2.9e-02	0.59000	0.035	0.00380
2	TCGA	Breast Invasive Carcinoma	0.0381	0.0167	0.0080	0.000	0.005	-0.001	NA	-0.001	0.340	2.8e-02	0.57000	NA	0.82000
3	TCGA	Thyroid Carcinoma	0.1260	0.0380	0.0004	0.013	0.047	0.030	NA	0.028	0.019	2.3e-05	0.00054	NA	0.00093

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Diastolic blood pressure, automated reading	5.9	18.1	23.0	-4.3	3.6	-4.8
Father’s age at death	5.3	7.0	15.2	1.3	-2.1	3.9
Heart attack/myocardial infarction (self-reported)	4.6	5.9	10.4	-2.1	3.2	-1.7
Unable to work because of sickness or disability	4.3	5.6	12.4	-1.7	1.1	-3.5
Heart attack	3.9	5.0	9.1	-1.9	3.0	-1.5
Medication: Blood pressure	3.9	6.9	10.0	-3.2	2.0	-2.6
Overall health rating	3.9	8.5	16.1	-2.6	1.6	-4.0
Hearing aid user	3.8	4.3	12.0	3.5	-0.7	0.7
Age at last live birth	3.6	5.2	6.5	1.8	-2.6	2.4
Medication for cholesterol, blood pressure or diabetes	3.5	5.8	7.7	2.8	-2.5	1.9
Medication: Aspirin	3.5	4.6	7.2	-2.7	1.4	-2.2
Alzheimer’s Disease (including proxy)	3.2	4.6	7.7	0.5	-2.4	2.8
Average weekly beer plus cider intake	3.2	4.6	9.0	-1.3	1.8	-3.0
Exposure to tobacco smoke outside home	3.1	4.2	9.3	-1.4	1.2	-3.0
Deep venous thrombosis (DVT) (self-reported)	3.1	3.9	8.1	-1.7	1.0	-2.8
Bipolar Disorder (2018)	3.0	4.8	12.1	0.5	-3.5	1.4
Townsend deprivation index at recruitment	3.0	4.2	7.8	-1.4	2.8	-1.7
Noisy workplace	3.0	3.7	10.2	0.8	-0.1	-3.2
Medication for pain relief, constipation, heartburn	3.0	5.1	10.4	2.2	0.5	3.2
Had other major operations	2.9	3.5	9.4	-0.9	0.6	-3.1
Pulse wave reflection index	2.9	3.6	8.0	-0.6	2.8	-1.5
Blood clot in the leg (DVT)	2.9	3.8	7.8	-1.5	1.1	-2.8
Number of operations (self-reported)	2.8	4.1	5.5	-2.1	-1.6	-2.3
Ever had hysterectomy (womb removed)	2.7	3.1	6.7	-2.6	0.3	-1.6
Medication: Atenolol	2.7	3.4	4.9	-1.7	1.5	-2.2
Medication: Cholesterol lowering	2.7	4.2	5.3	-2.3	1.7	-2.1
Cardiovascular Disease	2.6	8.7	14.6	-3.1	1.4	-3.8
Number of incorrect matches in round	2.6	4.2	7.1	2.7	-2.1	1.2
Qualifications: College or University degree	2.6	8.2	17.8	1.3	-2.3	4.2
Medication: Omeprazole	2.6	3.1	6.5	-1.5	0.9	-2.5
Medication: Aspirin	2.6	3.4	5.4	-2.3	1.5	-1.6
Alcohol usually taken with meals	2.5	4.1	8.0	1.8	-1.0	2.8
Qualifications: A levels/AS levels or equivalent	2.4	5.2	9.7	1.0	-3.1	2.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.4	2.9	4.4	-2.0	0.3	-2.1
Mother’s age at death	2.4	2.9	6.3	2.5	-0.8	1.4
Systolic Blood Pressure	2.3	11.7	17.3	-3.8	1.7	-4.2
Leg fat percentage (right)	2.3	8.4	12.4	-1.3	3.5	-3.3
Ulcerative Colitis	2.2	3.3	9.4	-0.6	-3.1	0.2
Irritable Bowel Disease (IBD)	2.1	4.9	14.2	-0.2	-3.8	-0.7
Ulcerative Colitis (UC)	2.1	3.9	11.4	-0.5	-3.4	-0.2
Neuroticism	2.1	5.0	11.0	-3.3	0.8	-1.9
Birth weight of first child	2.1	3.8	9.3	1.4	0.2	3.0
Qualifications: O levels/GCSEs or equivalent	2.1	3.3	5.3	1.1	-2.3	1.8
Bipolar Disorder or Schizophrenia	2.0	4.8	8.8	-0.5	-2.3	3.0
Other serious medical condition/disability diagnosed by doctor	2.0	2.6	4.9	-2.2	-1.7	-0.3
Ever highly irritable/argumentative for 2 days	2.0	2.4	5.8	-1.2	0.2	-2.4
Number of children fathered	2.0	2.3	3.6	1.2	-1.3	1.9
Frequency of depressed mood in last 2 weeks	1.9	2.7	4.4	0.3	1.9	-2.1
Medication: Ibuprofen (e.g. Nurofen)	1.9	2.4	4.4	0.9	-2.1	1.4
Length of working week for main job	1.9	2.1	2.8	1.2	-1.7	-1.5
Heart disease (mother)	1.9	2.3	5.5	-0.1	1.1	-2.4
Comparative height size at age 10	1.9	10.4	20.3	3.2	-0.8	4.5
Number of treatments/medications taken	1.8	3.3	5.2	-2.1	0.5	-2.3
Angina	1.8	2.4	4.0	-1.5	2.0	-0.9
Bilateral oophorectomy (both ovaries removed)	1.8	2.0	4.4	-2.1	0.9	-0.9
Financial difficulties in last 2 years	1.8	2.4	3.1	-1.3	1.8	-1.6
Medication: Ibuprofen	1.8	2.1	3.5	0.7	-1.9	1.5
Had major operations	1.8	2.1	4.8	-1.1	-2.2	-0.5
Hypertension (Self-reported)	1.8	5.1	11.2	-1.7	1.2	-3.3
Ever had bowel cancer screening	1.8	2.2	3.6	-1.0	-1.4	1.9
Leg fat percentage (left)	1.8	6.7	11.5	-1.0	3.4	-2.8
High blood pressure	1.7	4.6	11.5	-1.3	0.7	-3.4
Frequency of tenseness / restlessness in last 2 weeks	1.7	2.6	6.4	-0.5	1.1	-2.5
Mouth/teeth dental problems: Loose teeth	1.7	2.0	3.6	-1.9	0.9	-1.3
Commuting to job workplace: Car/motor vehicle	1.7	2.0	3.0	1.7	-1.4	-0.9
Medication for cholesterol	1.7	2.6	6.5	1.1	0.1	2.5
Eye problems/disorders: Glaucoma	1.7	2.0	5.4	0.5	-0.4	2.3
Vascular/heart problems diagnosed by doctor	1.7	4.5	9.1	1.7	-1.2	3.0
Alzheimer’s Disease (in mother)	1.6	1.8	4.2	0.2	-1.1	2.1
Ovarian Cancer	1.6	2.1	3.7	-1.4	0.8	-1.9
Coronary Artery Disease (CAD)	1.6	2.0	3.7	-1.9	1.0	-1.1
Pack years adult smoking proportion	1.6	2.5	4.8	-1.4	0.7	-2.2
Qualifications: None of the above	1.6	3.4	8.0	-1.5	0.0	-2.8
Angina (self-reported)	1.6	2.1	2.9	-1.5	1.7	-1.1
Medication: Atorvastatin	1.6	2.0	2.9	-1.7	0.5	-1.7
Ever had prostate specific antigen (PSA) test	1.6	1.8	3.0	0.1	-1.7	1.5
Supplements: Glucosamine	1.5	1.9	4.1	2.0	-0.8	1.0
Medication: Amlodipine	1.5	2.2	2.3	-1.5	1.4	-1.5
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.7	4.6	-0.7	-2.1	0.2
Average weekly red wine intake	1.5	2.2	4.9	-1.1	-0.5	2.2
Basal cell carcinoma (self-reported)	1.5	1.8	2.7	1.6	0.3	1.6
Intelligence (Savage-Jansen 2018)	1.4	4.2	8.7	1.8	-0.8	2.9
Age at First Birth	1.4	2.0	4.5	-0.3	2.1	1.2
Diabetes (father)	1.4	1.7	2.9	1.7	-0.6	-1.4
Diverticular disease/diverticulitis (self-reported)	1.4	1.6	3.3	-1.0	-0.7	-1.8
Glaucoma (self-reported)	1.4	1.7	2.5	-0.2	-1.6	1.6
High blood pressure (siblings)	1.4	2.1	4.2	-1.1	0.9	-2.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.8	5.1	-0.5	-2.3	0.2
Age at first live birth	1.4	2.6	4.2	1.7	-0.7	2.0
Supplements: Vitamin C	1.4	1.7	4.1	-2.0	0.4	-0.8
Handedness (chirality/laterality): Left-handed	1.4	1.7	3.3	-0.2	-1.4	1.8
Osteoporosis (self-reported)	1.4	1.8	3.2	1.8	-1.4	0.6
Medication: Bendroflumethiazide	1.4	2.2	6.5	-0.0	0.2	-2.5
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	4.5	-0.8	0.1	-2.1
Schizophrenia (2018)	1.3	2.7	7.0	-1.1	-0.1	2.6
Crohns Disease (2012)	1.3	2.0	4.5	0.4	-2.1	-1.2
HbA1C	1.3	1.5	3.4	-0.7	-1.9	0.7
Systolic blood pressure, automated reading	1.3	3.8	4.5	-2.0	1.7	-2.1
Heel bone mineral density (BMD) T-score, automated (left)	1.3	2.9	4.0	-1.1	-2.0	-1.8
Standing height	1.3	12.6	30.1	2.7	0.3	5.5
Birth weight	1.3	2.9	7.5	2.7	0.4	1.1
Neuroticism (Nagel 2018)	1.2	2.9	7.0	-2.6	-0.1	-1.3
Crohns Disease (2017)	1.2	2.5	6.8	0.2	-2.6	-0.9
Heel T-Score	1.2	9.7	14.1	-2.2	-3.8	-3.1
Medication for hormone replacement therapy	1.2	1.3	1.4	-1.2	-1.1	-1.2
Diabetes (mother)	1.2	1.6	3.0	1.7	-0.0	-1.3
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.7	4.1	-1.2	-2.0	-1.6
Ever unenthusiastic/disinterested for a whole week	1.2	1.4	2.5	-0.2	1.6	-1.3
Illnesses of siblings	1.2	1.7	2.6	0.5	-1.5	1.6
Asthma	1.2	2.4	5.6	-1.2	2.4	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.8	4.1	-1.1	-2.0	-0.1
Body fat percentage	1.2	4.7	8.5	-1.6	2.9	-1.7
Emphysema/chronic bronchitis	1.2	1.4	2.0	-1.4	-0.7	-1.3
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	2.3	1.5	-1.0	1.1
Asthma (self-reported)	1.2	2.5	5.8	-1.0	2.4	-0.8
Pack years of smoking	1.2	1.8	3.9	-1.1	0.6	-2.0
Neuroticism (2016)	1.1	1.6	3.3	-1.2	-0.1	-1.8
Schizophrenia (2014)	1.1	2.4	6.7	-0.2	-0.7	2.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	3.6	-0.7	0.7	-1.9
Serious illness, injury or assault to yourself	1.1	1.4	3.4	-1.8	0.4	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	2.3	1.1	0.1	-1.5
Mineral and other dietary supplements	1.1	1.4	2.2	-0.4	1.4	-1.5
Wears glasses or contact lenses	1.1	1.3	1.8	-1.1	1.3	1.0
Medication: Paracetamol	1.1	1.7	3.1	-1.1	-0.8	-1.8
Age started oral contraceptive pill	1.1	1.4	2.6	1.6	-0.3	1.3
Heart disease (siblings)	1.1	1.4	2.1	-0.8	1.2	-1.5
Worry (Nagel 2018)	1.0	2.1	5.9	-2.4	-0.3	-0.5
Height	1.0	20.1	46.4	3.2	1.9	6.8
Fed-up feelings	1.0	1.8	2.8	-1.0	1.3	-1.7
Taking other prescription medications	1.0	1.5	3.4	-1.1	0.1	-1.8
Body mass index (BMI)	1.0	4.1	9.6	-1.4	0.9	-3.1
Pain all over the body in last month	1.0	1.1	2.9	-0.5	0.3	-1.7
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	3.3	-0.1	-1.8	0.0
Medication: Paracetamol	1.0	1.7	3.1	-0.7	-1.2	-1.8
Wheeze or whistling in the chest in last year	1.0	1.8	4.6	-0.9	2.1	-0.4
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	2.5	0.8	1.6	-0.5
Illnesses of siblings: Diabetes	1.0	1.2	3.0	1.7	0.6	0.4
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	4.7	0.1	0.3	2.2
Medication: Blood pressure	1.0	1.9	5.6	-0.2	0.0	-2.4
Verbal and Numeric Reasoning (VNR)	0.9	2.3	3.3	1.8	-1.0	1.6
Mean Putamen Volume	0.9	1.0	2.9	-0.2	-0.2	1.7
Allergy or Eczema	0.9	2.4	4.8	-0.4	-2.2	1.5
Arm fat percentage (right)	0.9	3.5	4.8	-2.2	1.2	-2.1
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.4	2.9	-1.1	0.3	-1.7
Illnesses of mother	0.9	1.2	2.0	-1.4	1.2	-0.3
Loud music exposure frequency	0.9	1.0	1.7	-1.3	-0.4	1.0
Shortness of breath walking on level ground	0.9	1.0	1.7	-0.9	0.8	-1.3
Arm fat percentage (left)	0.9	3.8	4.8	-1.9	1.7	-2.2
Long-standing illness, disability or infirmity	0.9	1.4	2.7	-1.2	-0.2	-1.6
Osteoarthritis (self-reported)	0.9	1.2	3.1	0.4	-1.8	-0.6
Cholesterol lowering medication	0.9	1.3	2.2	0.7	-1.0	-1.5
Supplements: Calcium	0.9	1.0	1.6	-1.1	-0.4	1.3
Depression (Nagel 2018)	0.8	1.2	1.4	-1.0	1.2	-1.1
Alzheimer’s Disease (in father)	0.8	0.8	1.6	-0.1	-1.3	0.9
Bipolar Disorder (2011)	0.8	0.8	1.3	1.1	-1.0	-0.2
Trunk fat percentage	0.8	3.3	7.1	-1.5	2.7	-0.8
Medication: Levothyroxine sodium	0.8	1.4	3.3	0.7	0.5	-1.8
Past tobacco smoking	0.8	1.4	2.1	1.5	-1.0	1.1
Hair/balding pattern: Pattern 3	0.8	1.2	2.0	-1.2	0.4	-1.4
Happiness	0.8	1.0	1.8	1.3	1.1	0.2
Mouth/teeth dental problems: Dentures	0.8	1.3	2.1	1.0	0.9	-1.5
Lung cancer (father)	0.8	0.9	1.8	1.3	0.4	0.9
Headache pain in last month	0.8	1.3	2.0	-1.0	-1.0	1.4
Gout (self-reported)	0.8	1.0	3.0	0.2	0.2	-1.7
Leg fat mass (right)	0.8	3.3	6.4	-0.4	2.5	-1.8
Suffer from ‘nerves’	0.8	1.2	2.4	-1.6	0.0	-1.2
Knee pain experienced in last month	0.8	1.3	2.4	-1.6	-0.9	-0.8
Ever taken oral contraceptive pill	0.8	0.9	1.3	-1.2	-0.3	1.1
Medication: Lisinopril	0.8	1.1	2.2	-0.9	0.3	-1.5
Lupus	0.7	1.1	3.1	-0.5	1.8	-0.2
Waist Hip Ratio (WHR)	0.7	3.2	5.3	1.3	-1.7	2.3
Smoking Status	0.7	1.6	2.9	-1.0	1.0	-1.7
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	1.6	0.3	1.3	-0.8
Sitting height	0.7	4.8	7.7	2.4	0.9	2.8
Chronic bronchitis/emphysema (father)	0.7	0.8	1.9	0.1	-0.7	-1.4
Impedance of leg (left)	0.7	3.4	8.7	0.2	3.0	1.2
Forced vital capacity (FVC)	0.7	2.8	4.5	2.1	-1.5	1.3
Neuroticism score	0.7	1.4	3.0	-1.7	0.9	-0.8
Forced expiratory volume in 1-second (FEV1)	0.7	2.4	4.4	2.1	-0.8	1.5
Number of full brothers	0.7	0.9	1.7	0.3	-1.0	-1.3
Health satisfaction	0.7	0.9	2.2	-1.5	-0.5	0.4
Migraine (self-reported)	0.7	0.8	1.7	-0.8	0.3	-1.3
Medication: Allopurinol	0.7	0.9	2.7	0.1	-0.1	-1.6
Mean time to correctly identify matches	0.7	1.4	3.4	1.8	-0.7	0.5
Chest pain or discomfort	0.7	1.0	2.4	-1.6	0.7	0.2
Family relationship satisfaction	0.7	0.8	1.3	0.9	-1.1	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	3.5	-0.4	0.7	1.9
Qualifications: nursing, teaching	0.7	1.0	2.9	0.3	-1.7	0.4
Commuting to job workplace: Walk	0.7	0.7	2.2	-0.1	-0.1	1.5
Breast cancer (self-reported)	0.7	0.9	2.1	1.5	0.7	0.3
Smoking status: Current	0.7	1.1	2.2	-0.0	1.1	-1.5
Illnesses of father: High blood pressure	0.7	0.8	2.3	-0.5	-1.5	-0.1
Leg fat mass (left)	0.7	2.9	6.1	-0.2	2.5	-1.6
Body Mass Index (BMI) (2010)	0.6	0.8	1.7	-0.1	0.8	1.3
Hypothyroidism (self reported)	0.6	1.3	2.2	-1.0	-0.8	-1.5
Respiratory disease	0.6	1.3	2.5	-1.1	1.6	0.1
Sensitivity / hurt feelings	0.6	1.0	2.4	-0.7	-0.3	-1.6
Relative age of first facial hair	0.6	1.2	2.1	1.3	1.4	0.2
Vitamin and mineral supplements	0.6	0.9	2.1	1.5	-0.4	-0.6
Impedance of leg (right)	0.6	2.8	8.1	-0.4	2.8	0.4
Average weekly fortified wine intake	0.6	0.7	1.3	-0.1	-0.9	-1.1
Relative age voice broke	0.6	1.0	2.4	-0.4	1.6	-0.6
Age when periods started (menarche)	0.6	1.5	3.2	-0.5	1.8	1.0
Hayfever, allergic rhinitis or eczema	0.6	1.3	2.2	0.1	-1.5	1.3
Hearing difficulty/problems with background noise	0.6	1.0	1.4	-0.7	1.0	-1.2
Worrier / anxious feelings	0.6	1.1	2.8	-1.7	-0.6	0.4
Falls in the last year	0.6	0.8	1.5	0.2	1.2	-0.9
Pulse wave Arterial Stiffness index	0.6	0.8	1.7	1.3	0.8	-0.0
Friendships satisfaction	0.6	0.7	1.8	0.5	-0.2	1.3
Illnesses of father: None of the above (group 1)	0.6	0.8	1.9	1.4	0.7	0.1
Miserableness	0.6	1.1	2.9	-1.7	-0.6	-0.0
Alcohol drinker status: Never	0.6	0.7	1.9	-1.4	0.5	-0.0
Myopia	0.6	0.9	2.4	-0.1	0.6	1.6
Depressed Affect (Nagel 2018)	0.5	1.2	1.8	-1.3	0.8	-1.1
Reaction Time	0.5	0.9	2.1	1.5	-0.7	-0.3
HDL Cholesterol	0.5	0.9	1.1	-1.1	1.1	-0.6
LDL Cholesterol	0.5	0.8	1.4	0.2	-1.2	1.0
Primary Biliary Cirrhosis	0.5	0.7	1.8	1.4	0.2	-0.4
Blood White Count	0.5	4.0	10.6	-0.4	1.1	-3.2
BMI	0.5	3.1	7.1	-1.3	0.7	-2.7
Hand grip strength (left)	0.5	1.3	2.5	0.8	-0.9	1.6
Medication: Co-codamol	0.5	0.6	1.2	-0.2	-1.1	-0.8
Severe depression (siblings)	0.5	0.5	1.1	0.5	-1.1	-0.4
Hand grip strength (right)	0.5	1.4	1.5	1.0	-1.2	1.2
Current tobacco smoking	0.5	0.8	1.2	0.1	1.1	-1.1
Nervous feelings	0.5	1.0	2.4	-1.5	0.7	-0.1
Hair/balding pattern: Pattern 2	0.5	0.6	1.0	0.6	-0.6	1.0
Had menopause	0.5	0.6	1.2	0.8	1.1	0.4
Mouth/teeth dental problems	0.5	0.8	1.8	-0.1	-1.4	-0.8
Medication: Simvastatin	0.5	0.7	1.6	-0.6	0.4	-1.3
Fluid intelligence score	0.5	1.0	2.1	-0.9	-0.5	1.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	2.3	1.4	-0.5	1.5
Tense / ‘highly strung’	0.5	0.8	2.3	-1.5	-0.2	-0.5
Comparative body size at age 10	0.5	1.5	1.9	1.4	-0.9	-1.3
Worry too long after embarrassment	0.5	0.8	1.0	-1.0	0.6	-1.0
Pulse wave peak to peak time	0.5	0.6	0.9	-0.9	-0.7	0.5
Whole body fat mass	0.5	2.2	5.3	-0.6	2.3	-0.9
Number of full sisters	0.5	0.6	1.3	0.6	-1.1	0.4
Illnesses of father: Heart disease	0.5	0.8	1.2	-1.1	1.0	-0.4
Supplements: Fish oil (including cod liver oil)	0.5	0.7	0.9	-0.9	-0.7	-0.9
Irritability	0.5	0.8	2.1	-1.4	-0.4	-0.2
Ever depressed for a whole week	0.5	0.6	1.0	-0.1	0.9	-1.0
Alcohol drinker status: Previous	0.5	0.5	1.0	-1.0	-0.1	-0.8
Impedance of whole body	0.5	2.5	4.1	-0.5	2.0	1.8
Schizophrenia vs Biploar Disorder	0.4	0.5	1.4	0.3	1.2	0.1
Prostate Cancer	0.4	0.6	1.4	-0.1	0.7	1.2
Blood Red Count	0.4	4.1	8.6	1.8	0.7	2.9
Lung FEV1/FVC ratio	0.4	1.8	4.7	0.8	0.3	2.2
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.0	-0.4	-0.7	1.0
Medication: Metformin	0.4	0.5	1.0	-0.2	-1.0	0.7
Maternal smoking around birth	0.4	0.6	1.7	1.3	-0.1	0.2
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.7	0.8	0.2	-0.7
Trunk fat mass	0.4	1.8	5.0	-0.6	2.2	-0.2
Hip circumference	0.4	1.9	2.2	-1.5	1.3	-1.3
Alcohol intake versus 10 years previously	0.4	0.6	1.2	0.2	-0.8	-1.1
Depression (self-reported)	0.4	0.5	1.3	-0.4	-1.1	0.3
Arm fat mass (right)	0.4	1.8	2.3	-1.4	1.1	-1.5
Exposure to tobacco smoke at home	0.4	0.5	1.1	-1.1	-0.5	0.3
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	2.2	-0.0	0.0	-1.5
Medication: Seretide 50 evohaler	0.4	0.4	0.5	-0.7	-0.5	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	1.1	-1.0	-0.5	0.2
Smoking status: Previous	0.4	0.5	1.3	-1.1	0.5	-0.2
Mood swings	0.4	0.7	1.5	-1.2	0.8	0.1
Loneliness, isolation	0.4	0.6	1.1	0.8	1.0	-0.1
Medication: Gliclazide	0.4	0.5	1.2	0.3	0.5	-1.1
Arm fat mass (left)	0.4	1.7	1.9	-1.2	1.4	-1.3
Number of self-reported non-cancer illnesses	0.4	0.8	1.2	-1.1	-0.3	-1.0
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.4	-0.4	0.1	-1.2
High cholesterol (Self-reported)	0.4	0.7	1.3	-0.3	0.9	-1.1
Commuting to job workplace: Cycle	0.4	0.5	1.3	-0.4	0.3	1.2
Breast Cancer	0.3	0.7	1.5	-0.5	1.2	-0.5
Triglycerides	0.3	0.5	0.9	0.3	-1.0	-0.6
Chronotype (morning person)	0.3	0.6	1.5	1.2	0.6	-0.2
Average weekly spirits intake	0.3	0.3	0.9	-1.0	-0.2	-0.2
Qualifications: CSEs or equivalent	0.3	0.4	0.9	-0.4	0.2	-1.0
Allergy	0.3	0.7	2.2	1.5	0.1	0.1
Medication: Ramipril	0.3	0.4	1.0	0.2	1.0	-0.4
Impedance of arm (right)	0.3	1.2	2.3	-1.1	0.5	1.5
Trunk fat-free mass	0.3	1.6	2.5	1.4	-0.5	1.6
Time employed in main current job	0.3	0.3	0.7	0.3	-0.3	0.9
Medication: Lansoprazole	0.3	0.3	0.6	0.2	0.8	0.6
Impedance of arm (left)	0.3	1.3	2.7	-0.6	0.9	1.6
Trunk predicted mass	0.3	1.6	2.8	1.4	-0.4	1.7
Breastfed as a baby	0.3	0.3	0.5	0.6	-0.7	0.3
Forced vital capacity (FVC), Best measure	0.3	0.9	1.6	1.3	-0.6	1.0
Arm fat-free mass (right)	0.3	1.5	1.8	1.3	0.9	1.3
Eye problems/disorders: Cataract	0.3	0.3	0.5	-0.6	-0.2	-0.7
Average weekly champagne plus white wine intake	0.3	0.4	1.1	0.0	0.1	1.0
Guilty feelings	0.3	0.5	1.0	-1.0	0.3	-0.6
Ever smoked	0.3	0.5	0.9	-1.0	-0.1	-0.6
Rheumatoid Arthritis	0.2	0.2	0.4	-0.6	0.2	0.6
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.4	0.7	-0.5	-0.1
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.7	-0.8	-0.6	0.6
Lung FVC	0.2	1.2	2.4	0.3	-1.0	-1.6
Supplements: Zinc	0.2	0.2	0.7	-0.8	-0.2	-0.1
Multivitamins +/- minerals	0.2	0.2	0.4	-0.6	-0.2	0.4
Stomach or abdominal pain in last month	0.2	0.2	0.3	-0.3	-0.4	0.6
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.6	-0.8	0.4	0.3
Number of live births	0.2	0.3	0.5	-0.7	-0.4	-0.6
Pulse rate	0.2	0.4	0.6	-0.8	-0.4	0.6
Hair/balding pattern: Pattern 4	0.2	0.4	1.1	0.4	0.0	-1.0
Peak expiratory flow (PEF)	0.2	0.5	1.2	0.5	1.1	0.3
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.6	0.0	0.1	-0.8
Eye problems/disorders: None of the above	0.2	0.2	0.5	0.7	0.2	-0.2
Arm predicted mass (right)	0.2	1.1	1.4	1.2	0.8	1.2
Whole body fat-free mass	0.2	1.0	1.7	1.1	-0.3	1.3
Whole body water mass	0.2	1.0	1.6	1.1	-0.4	1.3
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.7	0.8	-0.0	-0.3
Risk taking	0.2	0.3	0.5	-0.0	-0.7	-0.5
Pain experienced in last month	0.2	0.4	0.5	0.7	0.3	0.7
Major Depression (MDD)	0.1	0.1	0.4	0.7	-0.1	0.0
Blood Eosinophil Count	0.1	0.4	0.7	-0.5	0.6	-0.9
Blood Platelet Count	0.1	0.6	1.2	0.7	-1.1	-0.2
Hearing difficulty/problems: Yes	0.1	0.2	0.4	0.7	-0.1	0.1
Waist circumference	0.1	0.2	0.4	0.4	0.4	-0.6
Diabetes (self-reported)	0.1	0.2	0.3	-0.4	-0.6	0.2
Weight	0.1	0.3	0.8	0.1	0.9	-0.5
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.3	-0.2	0.5	0.5
Chronic bronchitis/emphysema (mother)	0.1	0.2	0.5	0.2	0.0	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.3	0.2	-0.6	-0.2
Alcohol intake frequency.	0.1	0.2	0.5	-0.0	0.7	-0.3
Leg pain on walking	0.1	0.2	0.3	0.4	0.1	-0.5
Leg fat-free mass (right)	0.1	0.5	0.8	0.7	-0.3	0.9
Diabetes diagnosed by doctor	0.1	0.1	0.4	-0.6	0.1	-0.1
Back pain experienced in last month	0.1	0.1	0.3	-0.6	0.2	0.0
Leg predicted mass (right)	0.1	0.5	0.8	0.8	-0.4	0.9
Commuting to job workplace: Public transport	0.1	0.1	0.3	-0.5	-0.3	-0.0
Basal metabolic rate	0.1	0.4	0.6	0.8	-0.0	0.7
Arm fat-free mass (left)	0.1	0.6	1.4	0.7	0.2	1.2
Fractured/broken bones in last 5 years	0.1	0.1	0.2	0.4	-0.3	-0.2
Arm predicted mass (left)	0.1	0.5	0.9	0.8	0.1	0.9
Fasting Glucose	0.0	0.1	0.2	-0.0	-0.4	-0.1
Hair Pigment	0.0	0.8	1.7	-0.4	1.3	-0.8
Tanning	0.0	0.3	0.5	0.6	-0.3	-0.7
Leg fat-free mass (left)	0.0	0.1	0.2	0.4	-0.1	0.3
High blood pressure (mother)	0.0	0.0	0.1	0.3	0.0	0.0
Leg predicted mass (left)	0.0	0.1	0.2	0.4	-0.0	0.3
Prospective memory result	0.0	0.0	0.1	0.0	-0.1	-0.3
Neck or shoulder pain in last month	0.0	0.0	0.1	-0.2	0.1	-0.3
Pulse rate, automated reading	0.0	0.1	0.1	0.1	-0.2	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.0	0.1	0.0	0.2	-0.2
Financial situation satisfaction	0.0	0.0	0.0	-0.0	-0.1	0.0

Hub : Genes

PPP2R2A

Models

Trait associations