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chr12:47,805,753-52,362,786

Best TWAS P=4.8e-15 · Best GWAS P=6.09e-15 conditioned to 0.0203

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	DIP2B	0.11	0.10	enet	16	0.13	2.6e-15	7.37	7.8	4.8e-15	0.81	0.05	0.95	TRUE
5	GTEx	Brain Cerebellar Hemisphere	PFKM	0.29	0.09	enet	14	0.06	1.5e-02	-6.28	7.0	3.4e-12	0.07	0.02	0.93	TRUE
28	METSIM	Adipose	DAZAP2	0.06	0.05	lasso	4	0.05	1.8e-07	-5.07	-5.3	1.4e-07	0.07	1.00	0.00	TRUE
30	YFS	Blood	ATF1	0.05	0.07	lasso	9	0.07	2.0e-21	7.62	7.6	2.4e-14	0.93	0.02	0.98	FALSE
37	The Cancer Genome Atlas	Brain Lower Grade Glioma	ATF1	0.03	0.04	lasso	1	0.04	6.3e-05	7.61	-7.6	2.8e-14	-0.94	0.01	0.99	FALSE
9	GTEx	Cells Transformed fibroblasts	SMARCD1	0.08	0.07	enet	5	0.07	9.3e-06	7.59	-7.4	1.6e-13	-0.50	0.01	0.99	FALSE
33	The Cancer Genome Atlas	Breast Invasive Carcinoma	SMARCD1	0.02	0.03	lasso	1	0.03	3.7e-06	7.24	-7.2	4.6e-13	-0.47	0.02	0.98	FALSE
27	GTEx	Whole Blood	RP4-605O3.4	0.04	0.04	lasso	4	0.01	1.5e-02	6.93	7.2	8.5e-13	0.58	0.05	0.82	FALSE
19	GTEx	Testis	SMARCD1	0.22	0.10	enet	22	0.10	2.6e-05	6.64	-7.1	1.6e-12	-0.51	0.07	0.91	FALSE
15	GTEx	Prostate	CERS5	0.19	0.08	lasso	4	0.02	1.2e-01	6.93	7.0	1.7e-12	0.62	0.08	0.18	FALSE
21	GTEx	Testis	CERS5	0.12	0.06	lasso	6	0.07	4.0e-04	7.00	7.1	1.7e-12	0.64	0.13	0.38	FALSE
13	GTEx	Nerve Tibial	CERS5	0.31	0.28	enet	20	0.36	2.2e-26	7.00	6.9	5.3e-12	0.64	0.25	0.75	FALSE
36	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LIMA1	0.08	0.10	blup	59	0.10	1.8e-11	6.53	-6.9	6.7e-12	-0.66	0.05	0.95	FALSE
8	GTEx	Brain Putamen basal ganglia	CERS5	0.29	0.12	enet	36	0.21	1.2e-05	7.13	6.8	7.1e-12	0.43	0.24	0.54	FALSE
29	NTR	Blood	ATF1	0.06	0.07	enet	35	0.07	4.0e-21	7.66	6.8	7.3e-12	0.78	0.02	0.98	FALSE
22	GTEx	Testis	ZNF641	0.16	0.07	lasso	2	0.10	4.2e-05	-5.75	6.8	1.0e-11	0.10	0.21	0.54	FALSE
4	GTEx	Brain Caudate basal ganglia	LIMA1	0.18	0.12	lasso	5	0.07	3.9e-03	7.24	6.8	1.3e-11	0.45	0.07	0.56	FALSE
20	GTEx	Testis	SLC11A2	0.17	0.13	enet	11	0.12	9.2e-06	-5.52	-6.7	1.9e-11	-0.42	0.69	0.22	FALSE
18	GTEx	Skin Sun Exposed Lower leg	ZNF641	0.21	0.03	enet	17	0.08	6.5e-07	-6.23	6.7	2.1e-11	0.10	0.45	0.54	FALSE
3	GTEx	Artery Tibial	RP4-605O3.4	0.04	0.01	lasso	4	0.00	3.2e-01	6.88	6.6	3.2e-11	0.53	0.10	0.58	FALSE
6	GTEx	Brain Cerebellar Hemisphere	RP4-605O3.4	0.18	0.12	enet	14	0.10	1.5e-03	7.00	6.5	6.7e-11	0.49	0.07	0.55	FALSE
10	GTEx	Heart Atrial Appendage	CERS5	0.14	0.03	lasso	6	0.02	4.2e-02	7.00	6.3	2.2e-10	0.54	0.15	0.74	FALSE
26	GTEx	Whole Blood	ATF1	0.07	0.09	lasso	4	0.07	3.5e-07	6.25	6.3	3.7e-10	0.78	0.93	0.07	FALSE
17	GTEx	Skin Sun Exposed Lower leg	SMARCD1	0.07	0.02	lasso	2	0.03	1.4e-03	-3.90	-6.0	2.4e-09	-0.49	0.06	0.82	FALSE
24	GTEx	Thyroid	ZNF641	0.16	0.06	enet	26	0.13	2.0e-10	-0.99	5.9	4.3e-09	0.08	0.83	0.16	FALSE
39	The Cancer Genome Atlas	Prostate Adenocarcinoma	LETMD1	0.03	0.03	blup	44	0.02	7.4e-03	-5.25	5.8	5.0e-09	0.38	0.01	0.87	FALSE
32	The Cancer Genome Atlas	Breast Invasive Carcinoma	C12orf62	0.01	0.00	blup	47	0.00	4.6e-02	-3.44	-5.8	8.2e-09	-0.45	0.02	0.56	FALSE
34	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C12orf62	0.02	0.01	blup	47	0.01	1.7e-02	-3.50	-5.7	9.3e-09	-0.43	0.02	0.60	FALSE
35	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ZNF641	0.04	0.03	lasso	1	0.03	5.9e-04	-5.74	5.7	9.6e-09	0.08	0.03	0.49	FALSE
7	GTEx	Brain Cerebellum	PFKM	0.20	0.07	lasso	10	0.07	4.2e-03	-5.74	5.7	1.3e-08	0.09	0.07	0.75	FALSE
14	GTEx	Nerve Tibial	RP4-605O3.4	0.11	0.00	lasso	3	0.00	1.7e-01	6.88	5.6	1.9e-08	0.52	0.06	0.64	FALSE
2	GTEx	Adipose Subcutaneous	ATF1	0.07	0.05	enet	14	0.04	3.1e-04	-4.52	-5.6	2.2e-08	-0.68	0.71	0.25	FALSE
25	GTEx	Thyroid	RP11-579D7.2	0.14	0.02	enet	31	0.02	7.3e-03	-5.74	5.6	2.5e-08	0.08	0.01	0.94	FALSE
16	GTEx	Skin Not Sun Exposed Suprapubic	ZNF641	0.15	0.11	enet	30	0.10	3.1e-06	4.19	5.5	3.1e-08	0.11	0.98	0.01	FALSE
31	YFS	Blood	LIMA1	0.04	0.06	enet	31	0.06	3.5e-19	-4.18	-5.5	4.5e-08	-0.65	1.00	0.00	FALSE
11	GTEx	Muscle Skeletal	ATF1	0.09	0.06	lasso	5	0.07	5.0e-07	-4.64	-5.3	1.0e-07	-0.64	0.60	0.40	FALSE
23	GTEx	Thyroid	CERS5	0.09	0.04	lasso	9	0.04	3.7e-04	-3.85	5.3	1.0e-07	0.45	0.66	0.30	FALSE
12	GTEx	Muscle Skeletal	TFCP2	0.05	0.01	lasso	2	0.00	1.2e-01	-5.25	-5.2	1.7e-07	-0.35	0.57	0.01	FALSE
38	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	LETMD1	0.03	0.02	lasso	4	0.02	1.9e-03	-5.10	5.2	2.4e-07	0.35	0.02	0.72	FALSE