Best TWAS P=4.8e-15 · Best GWAS P=6.09e-15 conditioned to 0.0203
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | DIP2B | 0.11 | 0.10 | enet | 16 | 0.13 | 2.6e-15 | 7.37 | 7.8 | 4.8e-15 | 0.81 | 0.05 | 0.95 | TRUE |
2 | GTEx | Adipose Subcutaneous | ATF1 | 0.07 | 0.05 | enet | 14 | 0.04 | 3.1e-04 | -4.52 | -5.6 | 2.2e-08 | -0.68 | 0.71 | 0.25 | FALSE |
3 | GTEx | Artery Tibial | RP4-605O3.4 | 0.04 | 0.01 | lasso | 4 | 0.00 | 3.2e-01 | 6.88 | 6.6 | 3.2e-11 | 0.53 | 0.10 | 0.58 | FALSE |
4 | GTEx | Brain Caudate basal ganglia | LIMA1 | 0.18 | 0.12 | lasso | 5 | 0.07 | 3.9e-03 | 7.24 | 6.8 | 1.3e-11 | 0.45 | 0.07 | 0.56 | FALSE |
5 | GTEx | Brain Cerebellar Hemisphere | PFKM | 0.29 | 0.09 | enet | 14 | 0.06 | 1.5e-02 | -6.28 | 7.0 | 3.4e-12 | 0.07 | 0.02 | 0.93 | TRUE |
6 | GTEx | Brain Cerebellar Hemisphere | RP4-605O3.4 | 0.18 | 0.12 | enet | 14 | 0.10 | 1.5e-03 | 7.00 | 6.5 | 6.7e-11 | 0.49 | 0.07 | 0.55 | FALSE |
7 | GTEx | Brain Cerebellum | PFKM | 0.20 | 0.07 | lasso | 10 | 0.07 | 4.2e-03 | -5.74 | 5.7 | 1.3e-08 | 0.09 | 0.07 | 0.75 | FALSE |
8 | GTEx | Brain Putamen basal ganglia | CERS5 | 0.29 | 0.12 | enet | 36 | 0.21 | 1.2e-05 | 7.13 | 6.8 | 7.1e-12 | 0.43 | 0.24 | 0.54 | FALSE |
9 | GTEx | Cells Transformed fibroblasts | SMARCD1 | 0.08 | 0.07 | enet | 5 | 0.07 | 9.3e-06 | 7.59 | -7.4 | 1.6e-13 | -0.50 | 0.01 | 0.99 | FALSE |
10 | GTEx | Heart Atrial Appendage | CERS5 | 0.14 | 0.03 | lasso | 6 | 0.02 | 4.2e-02 | 7.00 | 6.3 | 2.2e-10 | 0.54 | 0.15 | 0.74 | FALSE |
11 | GTEx | Muscle Skeletal | ATF1 | 0.09 | 0.06 | lasso | 5 | 0.07 | 5.0e-07 | -4.64 | -5.3 | 1.0e-07 | -0.64 | 0.60 | 0.40 | FALSE |
12 | GTEx | Muscle Skeletal | TFCP2 | 0.05 | 0.01 | lasso | 2 | 0.00 | 1.2e-01 | -5.25 | -5.2 | 1.7e-07 | -0.35 | 0.57 | 0.01 | FALSE |
13 | GTEx | Nerve Tibial | CERS5 | 0.31 | 0.28 | enet | 20 | 0.36 | 2.2e-26 | 7.00 | 6.9 | 5.3e-12 | 0.64 | 0.25 | 0.75 | FALSE |
14 | GTEx | Nerve Tibial | RP4-605O3.4 | 0.11 | 0.00 | lasso | 3 | 0.00 | 1.7e-01 | 6.88 | 5.6 | 1.9e-08 | 0.52 | 0.06 | 0.64 | FALSE |
15 | GTEx | Prostate | CERS5 | 0.19 | 0.08 | lasso | 4 | 0.02 | 1.2e-01 | 6.93 | 7.0 | 1.7e-12 | 0.62 | 0.08 | 0.18 | FALSE |
16 | GTEx | Skin Not Sun Exposed Suprapubic | ZNF641 | 0.15 | 0.11 | enet | 30 | 0.10 | 3.1e-06 | 4.19 | 5.5 | 3.1e-08 | 0.11 | 0.98 | 0.01 | FALSE |
17 | GTEx | Skin Sun Exposed Lower leg | SMARCD1 | 0.07 | 0.02 | lasso | 2 | 0.03 | 1.4e-03 | -3.90 | -6.0 | 2.4e-09 | -0.49 | 0.06 | 0.82 | FALSE |
18 | GTEx | Skin Sun Exposed Lower leg | ZNF641 | 0.21 | 0.03 | enet | 17 | 0.08 | 6.5e-07 | -6.23 | 6.7 | 2.1e-11 | 0.10 | 0.45 | 0.54 | FALSE |
19 | GTEx | Testis | SMARCD1 | 0.22 | 0.10 | enet | 22 | 0.10 | 2.6e-05 | 6.64 | -7.1 | 1.6e-12 | -0.51 | 0.07 | 0.91 | FALSE |
20 | GTEx | Testis | SLC11A2 | 0.17 | 0.13 | enet | 11 | 0.12 | 9.2e-06 | -5.52 | -6.7 | 1.9e-11 | -0.42 | 0.69 | 0.22 | FALSE |
21 | GTEx | Testis | CERS5 | 0.12 | 0.06 | lasso | 6 | 0.07 | 4.0e-04 | 7.00 | 7.1 | 1.7e-12 | 0.64 | 0.13 | 0.38 | FALSE |
22 | GTEx | Testis | ZNF641 | 0.16 | 0.07 | lasso | 2 | 0.10 | 4.2e-05 | -5.75 | 6.8 | 1.0e-11 | 0.10 | 0.21 | 0.54 | FALSE |
23 | GTEx | Thyroid | CERS5 | 0.09 | 0.04 | lasso | 9 | 0.04 | 3.7e-04 | -3.85 | 5.3 | 1.0e-07 | 0.45 | 0.66 | 0.30 | FALSE |
24 | GTEx | Thyroid | ZNF641 | 0.16 | 0.06 | enet | 26 | 0.13 | 2.0e-10 | -0.99 | 5.9 | 4.3e-09 | 0.08 | 0.83 | 0.16 | FALSE |
25 | GTEx | Thyroid | RP11-579D7.2 | 0.14 | 0.02 | enet | 31 | 0.02 | 7.3e-03 | -5.74 | 5.6 | 2.5e-08 | 0.08 | 0.01 | 0.94 | FALSE |
26 | GTEx | Whole Blood | ATF1 | 0.07 | 0.09 | lasso | 4 | 0.07 | 3.5e-07 | 6.25 | 6.3 | 3.7e-10 | 0.78 | 0.93 | 0.07 | FALSE |
27 | GTEx | Whole Blood | RP4-605O3.4 | 0.04 | 0.04 | lasso | 4 | 0.01 | 1.5e-02 | 6.93 | 7.2 | 8.5e-13 | 0.58 | 0.05 | 0.82 | FALSE |
28 | METSIM | Adipose | DAZAP2 | 0.06 | 0.05 | lasso | 4 | 0.05 | 1.8e-07 | -5.07 | -5.3 | 1.4e-07 | 0.07 | 1.00 | 0.00 | TRUE |
29 | NTR | Blood | ATF1 | 0.06 | 0.07 | enet | 35 | 0.07 | 4.0e-21 | 7.66 | 6.8 | 7.3e-12 | 0.78 | 0.02 | 0.98 | FALSE |
30 | YFS | Blood | ATF1 | 0.05 | 0.07 | lasso | 9 | 0.07 | 2.0e-21 | 7.62 | 7.6 | 2.4e-14 | 0.93 | 0.02 | 0.98 | FALSE |
31 | YFS | Blood | LIMA1 | 0.04 | 0.06 | enet | 31 | 0.06 | 3.5e-19 | -4.18 | -5.5 | 4.5e-08 | -0.65 | 1.00 | 0.00 | FALSE |
32 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C12orf62 | 0.01 | 0.00 | blup | 47 | 0.00 | 4.6e-02 | -3.44 | -5.8 | 8.2e-09 | -0.45 | 0.02 | 0.56 | FALSE |
33 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SMARCD1 | 0.02 | 0.03 | lasso | 1 | 0.03 | 3.7e-06 | 7.24 | -7.2 | 4.6e-13 | -0.47 | 0.02 | 0.98 | FALSE |
34 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C12orf62 | 0.02 | 0.01 | blup | 47 | 0.01 | 1.7e-02 | -3.50 | -5.7 | 9.3e-09 | -0.43 | 0.02 | 0.60 | FALSE |
35 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ZNF641 | 0.04 | 0.03 | lasso | 1 | 0.03 | 5.9e-04 | -5.74 | 5.7 | 9.6e-09 | 0.08 | 0.03 | 0.49 | FALSE |
36 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LIMA1 | 0.08 | 0.10 | blup | 59 | 0.10 | 1.8e-11 | 6.53 | -6.9 | 6.7e-12 | -0.66 | 0.05 | 0.95 | FALSE |
37 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ATF1 | 0.03 | 0.04 | lasso | 1 | 0.04 | 6.3e-05 | 7.61 | -7.6 | 2.8e-14 | -0.94 | 0.01 | 0.99 | FALSE |
38 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | LETMD1 | 0.03 | 0.02 | lasso | 4 | 0.02 | 1.9e-03 | -5.10 | 5.2 | 2.4e-07 | 0.35 | 0.02 | 0.72 | FALSE |
39 | The Cancer Genome Atlas | Prostate Adenocarcinoma | LETMD1 | 0.03 | 0.03 | blup | 44 | 0.02 | 7.4e-03 | -5.25 | 5.8 | 5.0e-09 | 0.38 | 0.01 | 0.87 | FALSE |