Hub : Genes

TFCP2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Lung	0.0773	0.0355	8.8e-03	0.016	NA	0.020	NA	0.023	1.9e-02	NA	1.1e-02	NA	6.5e-03
2	GTEx	Muscle Skeletal	0.0499	0.0249	9.1e-03	0.011	NA	0.001	NA	0.004	2.5e-02	NA	2.6e-01	NA	1.2e-01
3	ROSMAP	Brain Pre-frontal Cortex	0.1115	0.0336	7.7e-07	0.062	0.063	0.061	0.075	0.077	2.0e-08	1.7e-08	2.5e-08	6.5e-10	4.3e-10
4	YFS	Blood	0.3580	0.0371	0.0e+00	0.323	0.313	0.344	0.339	0.342	3.7e-109	3.8e-105	1.0e-117	9.1e-116	7.4e-117
5	TCGA	Brain Lower Grade Glioma	0.0292	0.0166	6.8e-03	0.006	0.008	0.005	NA	0.003	6.1e-02	3.8e-02	8.6e-02	NA	1.3e-01
6	TCGA	Prostate Adenocarcinoma	0.0304	0.0173	7.8e-03	0.020	0.024	0.019	NA	0.017	3.4e-03	1.4e-03	3.9e-03	NA	6.2e-03
7	TCGA	Thyroid Carcinoma	0.0540	0.0270	2.4e-03	0.049	0.016	0.032	NA	0.047	1.6e-05	9.1e-03	3.7e-04	NA	2.1e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.2	0.3	0.7	-0.5	-0.1	-0.5	-0.8	-0.8	-0.1	-0.4
Bipolar Disorder or Schizophrenia	0.2	0.5	1.6	-1.3	-0.0	-0.6	-0.6	-1.1	0.2	-0.2
Depressed Affect (Nagel 2018)	1.3	2.8	5.7	-2.2	-0.6	-1.4	-2.3	-1.3	-0.1	-2.4
Depression (Nagel 2018)	0.1	0.1	0.4	-0.1	-0.6	0.3	0.0	-0.2	0.1	0.1
Intelligence (Savage-Jansen 2018)	0.8	2.5	6.6	0.2	2.6	-1.2	-0.5	-1.6	-2.4	-0.8
Neuroticism (Nagel 2018)	1.6	3.8	7.2	-2.1	0.4	-1.9	-2.3	-2.2	-1.1	-2.7
Schizophrenia (2018)	0.2	0.3	1.5	-1.2	0.0	-0.4	-0.2	-0.7	0.3	-0.0
Schizophrenia vs Biploar Disorder	3.0	3.9	8.2	-0.2	-1.8	1.6	2.3	2.1	2.9	1.9
Worry (Nagel 2018)	0.9	1.9	3.8	-1.6	0.1	-1.1	-1.4	-2.0	-0.9	-1.7
Alzheimer’s Disease (in mother)	1.0	1.2	3.4	-1.9	0.4	-1.4	-1.1	-0.5	-0.2	-1.2
Alzheimer’s Disease (in father)	0.3	0.3	0.7	-0.6	0.0	-0.8	-0.5	-0.6	-0.3	-0.8
Alzheimer’s Disease (including proxy)	1.0	1.4	3.4	-1.8	0.3	-1.8	-1.0	-0.7	-0.4	-1.3
Crohns Disease (2017)	1.5	3.2	8.8	-1.6	-2.4	0.6	0.6	2.1	3.0	0.8
Irritable Bowel Disease (IBD)	0.8	1.8	3.5	0.2	-1.4	1.2	1.0	1.9	1.7	1.4
Ulcerative Colitis (UC)	0.8	1.6	2.8	1.6	-0.4	1.7	1.2	1.2	0.2	1.6
Major Depression (MDD)	0.1	0.1	0.5	-0.3	0.7	-0.3	0.0	-0.3	-0.2	-0.4
Reaction Time	0.2	0.4	0.9	-0.3	-0.6	0.9	1.0	-0.4	0.7	0.4
Verbal and Numeric Reasoning (VNR)	1.2	3.0	6.9	0.1	2.6	-1.2	-0.8	-1.9	-2.6	-1.1
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	0.2	0.3	0.6	-0.8	-0.6	-0.3	-0.6	-0.5	0.1	-0.5
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	1.1	1.6	5.0	0.6	-2.2	1.3	0.5	1.4	1.2	0.8
Bipolar Disorder (2011)	2.9	2.8	4.2	-1.1	1.3	-1.9	-1.9	-2.1	-1.9	-1.5
Body Mass Index (BMI) (2010)	0.4	0.5	1.4	0.7	0.7	-0.3	-0.3	-0.9	-1.2	-0.2
Coronary Artery Disease (CAD)	0.7	0.8	2.8	0.4	1.7	-0.3	0.0	-0.8	-1.4	0.0
Crohns Disease (2012)	0.6	0.9	2.3	-0.5	-1.1	0.2	0.2	1.5	1.4	0.5
Mean Putamen Volume	2.6	3.0	4.5	-2.0	0.3	-1.8	-2.0	-2.1	-1.0	-1.9
Fasting Glucose	0.4	0.5	1.2	-0.0	0.6	-0.7	-1.0	-0.2	-0.7	-1.1
HbA1C	2.7	2.9	8.0	1.4	2.8	-0.6	-0.3	-1.9	-2.5	-0.4
HDL Cholesterol	0.2	0.4	1.0	-0.6	0.9	-0.6	-0.2	-1.0	-0.4	-0.4
LDL Cholesterol	0.4	0.7	2.1	1.4	1.2	0.4	0.6	0.5	-0.6	0.5
Lupus	1.0	1.5	2.2	0.9	-1.2	1.2	1.5	1.0	1.3	1.5
Neuroticism (2016)	1.1	1.6	3.9	-1.3	-0.3	-1.2	-1.5	-1.1	-0.7	-2.0
Primary Biliary Cirrhosis	2.2	3.1	5.6	-1.6	1.3	-1.9	-1.5	-2.4	-1.7	-1.8
Rheumatoid Arthritis	1.8	2.5	5.7	-2.4	-0.6	-1.9	-1.9	-0.3	0.6	-1.9
Schizophrenia (2014)	0.4	0.8	2.5	-1.6	0.5	-1.2	-0.7	-0.9	-0.1	-0.5
Triglycerides	1.3	2.2	4.7	2.2	1.5	1.2	1.9	0.5	-0.7	1.6
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.2	0.1	-0.5	0.1	0.3	0.3	0.2	0.2
Ulcerative Colitis	0.7	1.0	3.7	1.9	0.3	1.2	0.5	0.2	-0.8	1.1
Blood Eosinophil Count	1.0	7.5	22.3	0.3	4.7	-1.7	-0.5	-3.5	-3.6	-0.9
Blood Platelet Count	0.8	9.7	20.0	-0.2	4.5	-2.3	-2.3	-4.0	-4.2	-2.0
Blood Red Count	0.6	6.2	10.3	1.3	-2.9	2.5	1.8	3.2	2.9	2.3
Blood White Count	1.9	13.8	42.0	-0.4	6.5	-3.6	-1.1	-3.7	-4.9	-1.6
Heel T-Score	0.8	6.2	19.1	-4.4	-2.9	-1.9	-1.5	0.1	2.6	-1.8
BMI	0.5	2.8	5.2	-1.9	0.2	-1.4	-2.3	-2.0	-1.3	-1.8
Height	0.8	16.1	48.8	-2.7	-7.0	1.4	0.1	4.2	6.1	0.5
Waist Hip Ratio (WHR)	0.8	3.6	9.2	3.0	2.0	1.4	1.9	-0.7	-1.9	1.6
Systolic Blood Pressure	0.6	3.1	4.4	-0.7	2.0	-1.9	-1.2	-2.1	-2.1	-1.8
Smoking Status	0.0	0.1	0.2	0.0	0.5	-0.1	0.2	0.3	0.1	0.2
Allergy or Eczema	0.7	1.8	4.4	0.5	-1.4	0.6	1.2	2.1	1.8	0.9
Cardiovascular Disease	2.2	7.2	13.3	-0.9	2.9	-2.0	-2.2	-3.5	-3.6	-2.6
Hypothyroidism (self reported)	0.0	0.1	0.2	-0.1	0.4	-0.5	0.2	-0.1	-0.3	-0.3
Respiratory disease	2.0	4.4	7.3	-2.2	1.3	-2.2	-1.9	-2.7	-1.7	-2.3
Type 2 Diabetes (T2D) (2018)	0.6	1.1	2.4	1.4	0.7	1.0	1.6	0.2	-0.2	1.4
Lung FEV1/FVC ratio	0.0	0.1	0.3	-0.6	-0.1	-0.2	-0.3	-0.3	-0.0	-0.5
Lung FVC	0.2	0.9	2.4	1.6	1.4	-0.1	0.1	0.5	-1.1	0.3
Neuroticism	2.4	5.8	10.0	-2.0	1.0	-2.4	-3.0	-2.7	-2.1	-3.2
Chronotype (morning person)	0.7	1.6	5.2	0.6	-2.3	1.0	-0.3	1.9	0.8	0.5
Hair Pigment	0.0	1.2	3.6	1.9	0.8	1.3	1.1	-0.3	-0.9	0.7
Tanning	0.1	1.4	3.4	1.8	-0.7	1.6	0.7	0.9	0.1	1.4
Hand grip strength (left)	1.3	3.4	9.6	1.5	-1.5	1.1	1.3	3.1	1.7	1.8
Number of treatments/medications taken	1.6	2.9	6.0	-0.0	2.3	-1.0	-1.0	-2.4	-2.4	-1.3
Average weekly spirits intake	0.2	0.2	0.6	0.7	0.6	0.7	-0.0	-0.0	-0.5	0.1
Sensitivity / hurt feelings	2.1	3.5	6.8	-1.6	1.3	-1.9	-1.7	-2.6	-1.7	-2.1
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.7	-0.8	-1.3	0.3	-0.4	-0.5	0.4	-0.2
Hearing difficulty/problems: Yes	1.2	1.9	3.2	-1.1	1.6	-1.8	-1.1	-1.2	-1.3	-1.4
Relative age of first facial hair	0.3	0.6	1.0	0.9	-0.3	0.8	1.0	0.8	0.6	0.8
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.5	0.7	1.2	0.4	-0.3	-0.6	-1.6	-0.5
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.4	-0.3	-0.2	-0.0	-0.7	-0.2	-0.3	-0.3
Ever had hysterectomy (womb removed)	0.7	0.8	2.0	-0.7	-1.1	-0.3	-0.2	1.4	1.2	-0.2
Systolic blood pressure, automated reading	0.7	2.1	2.8	-0.8	1.4	-1.7	-1.2	-1.6	-1.6	-1.6
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.3	0.1	-0.1	0.2	0.7	1.1	0.6	0.7
Angina	0.9	1.2	3.1	1.8	1.2	1.2	0.9	-0.5	-1.0	0.8
Medication for hormone replacement therapy	1.5	1.7	2.7	-1.4	0.1	-1.2	-1.6	-1.4	-1.3	-1.5
Vitamin and mineral supplements	1.3	1.8	4.0	1.8	0.2	1.2	2.0	1.0	0.6	1.6
Supplements: Zinc	0.2	0.2	0.8	-0.2	-0.3	-0.1	0.2	0.9	0.6	0.6
Medication: Co-codamol	0.5	0.6	2.1	0.1	-1.4	1.0	0.2	0.7	0.6	0.4
Medication: Metformin	0.1	0.2	0.6	0.4	0.8	-0.1	0.3	0.2	-0.5	0.3
Diabetes (father)	0.4	0.5	0.9	-0.3	0.6	-0.7	-0.6	-0.9	-0.9	-0.8
Diabetes (mother)	0.2	0.2	0.5	0.1	0.5	-0.2	-0.5	-0.7	-0.6	-0.3
Severe depression (siblings)	3.7	4.1	11.1	1.9	3.3	-0.3	-0.0	-2.2	-3.1	-0.0
Pack years adult smoking proportion	2.9	4.4	7.8	1.4	-1.3	1.9	2.4	2.8	2.1	2.3
Impedance of leg (right)	0.3	1.6	4.4	-2.1	-1.4	-0.3	0.3	0.7	2.1	-0.3
Leg fat-free mass (left)	0.2	1.2	2.8	-1.5	-1.5	-0.4	-1.7	-0.4	0.2	-1.0
Trunk fat percentage	1.0	4.0	12.2	-3.5	-0.5	-1.6	-2.1	-2.0	-0.2	-2.1
Hand grip strength (right)	1.3	3.6	8.7	1.4	-1.6	1.3	1.6	3.0	1.9	2.1
Townsend deprivation index at recruitment	1.6	2.2	6.4	-1.8	-2.5	0.3	0.0	0.9	2.2	0.0
Current tobacco smoking	0.1	0.1	0.5	-0.0	0.1	0.1	0.3	0.7	0.6	0.2
Average weekly fortified wine intake	0.6	0.7	1.8	1.4	1.0	0.7	0.6	-0.3	-1.0	0.5
Maternal smoking around birth	0.1	0.2	0.5	-0.6	-0.3	0.3	0.5	0.3	0.7	0.3
Fed-up feelings	0.5	0.9	2.5	-0.7	-0.4	-0.8	-1.6	-0.7	-0.6	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.4	3.8	-0.4	-1.9	1.0	0.7	0.7	1.7	1.0
Relative age voice broke	0.3	0.4	1.0	1.0	0.7	0.4	0.9	0.0	-0.0	0.6
Taking other prescription medications	1.0	1.6	3.5	0.3	1.8	-0.3	-0.3	-1.8	-1.9	-0.9
Age when periods started (menarche)	0.4	0.9	3.2	-1.8	-0.4	-0.9	-0.3	-0.8	0.7	-1.0
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	3.1	-1.0	-1.8	-0.0	-0.4	0.9	1.1	0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	2.9	-1.7	-0.3	-1.3	-1.2	-0.9	0.0	-1.5
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.8	-0.9	0.5	-0.1	0.1	-0.7	0.1	0.1
Qualifications: CSEs or equivalent	0.5	0.7	1.7	-1.3	-0.4	-0.4	-0.9	-1.1	-0.3	-0.8
Serious illness, injury or assault to yourself	3.1	3.7	6.2	-1.5	1.1	-1.4	-2.5	-2.2	-2.0	-2.3
High blood pressure	2.4	6.6	11.1	-1.1	2.5	-2.1	-2.3	-3.3	-3.2	-2.7
Hayfever, allergic rhinitis or eczema	0.5	1.1	2.5	-1.0	-1.5	-0.6	-0.1	1.4	1.6	-0.3
Multivitamins +/- minerals	0.8	1.0	3.9	-2.0	-0.5	-0.8	-1.1	-0.1	0.6	-1.0
Stomach or abdominal pain in last month	0.5	0.6	1.9	-1.2	-1.4	0.3	-0.4	-0.4	0.8	-0.4
Supplements: Glucosamine	1.2	1.5	4.5	-1.2	-2.1	0.6	-0.3	1.0	1.8	0.1
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.8	0.3	0.8	1.0	1.3	0.1	0.6	1.1
Medication: Atenolol	0.4	0.5	1.5	0.8	-0.5	1.2	0.7	0.3	0.5	0.8
Medication: Levothyroxine sodium	1.0	1.6	3.6	-1.1	1.2	-1.9	-1.2	-0.9	-1.1	-1.4
Sitting height	0.6	3.9	14.4	-1.5	-3.8	0.7	-0.8	2.0	2.5	-0.0
Chronic bronchitis/emphysema (father)	0.8	0.9	2.2	-1.5	0.7	-0.8	-0.9	-1.1	-0.5	-0.8
High blood pressure (mother)	3.2	4.5	10.2	0.4	2.9	-1.1	-1.3	-2.9	-3.2	-1.4
Body mass index (BMI)	0.4	1.9	3.7	-1.3	0.4	-0.9	-1.8	-1.9	-1.4	-1.3
Impedance of leg (left)	0.6	2.7	7.8	-2.1	-2.2	0.1	0.5	1.1	2.8	-0.1
Leg predicted mass (left)	0.2	1.2	2.8	-1.4	-1.4	-0.4	-1.7	-0.5	0.1	-1.0
Trunk fat mass	0.7	2.9	9.8	-3.1	-1.3	-1.0	-1.8	-1.3	0.4	-1.6
Waist circumference	0.1	0.3	1.0	-0.8	-0.3	0.3	-0.6	-1.0	-0.4	-0.3
Number of incorrect matches in round	0.9	1.4	2.1	0.9	-1.0	1.2	1.4	1.1	1.4	1.4
Past tobacco smoking	0.1	0.2	0.6	-0.2	0.1	-0.5	-0.4	-0.8	-0.4	-0.4
Alcohol usually taken with meals	0.8	1.2	3.1	0.8	1.7	-0.7	-0.2	-1.2	-1.7	-0.2
Nervous feelings	1.2	2.3	3.6	-1.5	0.3	-1.5	-1.9	-1.7	-1.2	-1.9
Frequency of tenseness / restlessness in last 2 weeks	2.4	3.7	7.3	-1.7	1.2	-1.6	-2.0	-2.7	-2.0	-2.0
Hearing difficulty/problems with background noise	1.0	1.6	2.4	-1.0	1.6	-1.5	-0.8	-1.4	-1.3	-1.1
Hair/balding pattern: Pattern 2	0.5	0.6	1.8	1.3	0.6	1.0	0.8	-0.5	-0.4	0.6
Had menopause	0.2	0.2	0.5	0.7	0.4	0.5	0.5	0.3	-0.2	0.2
Had other major operations	3.2	3.9	8.6	1.0	-1.4	1.7	2.1	2.9	2.2	2.0
Forced vital capacity (FVC)	0.4	1.4	2.8	-1.1	-1.7	-0.7	-0.7	1.5	1.5	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	1.3	3.0	7.7	-2.8	0.1	-2.1	-1.8	-1.1	-0.0	-2.0
Ever unenthusiastic/disinterested for a whole week	3.3	4.0	9.4	0.6	3.1	-1.3	-0.8	-2.5	-2.8	-1.3
Qualifications: None of the above	0.6	1.4	3.9	1.0	-0.6	2.0	1.1	0.8	0.9	1.2
Financial difficulties in last 2 years	1.3	1.8	4.8	-2.2	-0.3	-1.0	-1.4	-1.3	0.1	-1.7
Mouth/teeth dental problems	0.9	1.4	4.2	-2.1	-0.0	-1.5	-1.0	-0.7	0.5	-1.1
Heart attack	0.4	0.5	1.7	-1.3	-0.1	-0.6	-0.9	-0.5	0.1	-0.5
Allergy	1.1	2.5	5.2	2.3	0.2	2.0	1.6	1.2	0.1	2.0
Pain all over the body in last month	0.6	0.7	2.3	-0.4	1.1	-0.1	-0.2	-1.5	-1.0	-0.4
Diabetes (self-reported)	0.1	0.1	0.2	0.4	0.4	0.3	0.4	0.2	-0.3	0.5
Hayfever/allergic rhinitis (self-reported)	1.0	1.4	3.0	-1.3	0.8	-1.7	-1.3	-0.8	-0.6	-1.4
Medication: Ramipril	0.5	0.7	2.9	0.3	0.4	0.2	-0.4	-1.7	-1.1	-0.3
Medication: Simvastatin	1.4	2.1	5.9	0.9	2.4	-0.2	-0.4	-1.5	-2.3	-0.6
Fluid intelligence score	1.3	2.7	3.9	-1.0	1.9	-1.8	-1.3	-1.6	-2.0	-1.6
Illnesses of siblings	0.5	0.8	1.6	0.8	-0.3	1.3	1.1	0.2	0.5	1.1
Neuroticism score	1.6	3.3	5.9	-1.7	0.3	-1.7	-2.2	-2.2	-1.3	-2.4
Weight	0.4	2.1	5.6	-2.4	-2.0	-0.4	-1.7	-0.5	0.8	-1.2
Impedance of arm (right)	1.1	5.0	12.6	-3.5	0.4	-3.0	-1.9	-1.5	0.0	-2.8
Arm fat percentage (right)	1.5	5.8	9.5	-3.1	0.9	-2.3	-2.7	-2.8	-1.6	-2.7
Trunk fat-free mass	0.4	2.5	8.3	-0.0	-2.9	1.6	0.1	1.6	1.9	0.9
Hip circumference	0.7	3.0	9.6	-3.1	-2.3	-0.3	-1.6	-0.7	1.3	-1.1
Time employed in main current job	0.3	0.3	1.3	1.1	0.3	0.2	0.1	0.2	-0.6	0.4
Alcohol intake versus 10 years previously	0.2	0.3	0.9	0.7	0.2	0.3	-0.2	-0.9	-0.8	-0.2
Father’s age at death	0.6	0.8	2.1	-1.5	-1.3	-0.5	-0.9	0.4	0.6	-0.5
Worrier / anxious feelings	0.6	1.1	4.9	-0.5	0.8	-0.3	-0.4	-2.2	-1.0	-0.8
Frequency of tiredness / lethargy in last 2 weeks	2.1	3.5	8.4	-2.9	-0.8	-1.5	-2.1	-1.8	-0.1	-2.3
Falls in the last year	0.2	0.3	1.4	-1.2	0.2	-0.7	-0.4	0.0	0.3	-0.4
Hair/balding pattern: Pattern 3	0.3	0.4	1.0	-0.3	0.6	-1.0	-0.8	0.4	-0.2	-0.6
Number of live births	2.2	3.1	7.8	-0.5	-1.4	1.4	2.2	1.2	2.8	1.7
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	2.5	-1.0	-1.6	-0.4	-0.6	1.2	1.4	-0.3
Pulse rate	0.3	0.5	1.4	-0.4	-1.2	0.3	-0.2	0.6	1.1	0.5
Happiness	0.1	0.2	0.3	0.2	-0.2	0.6	0.6	0.1	0.4	0.5
Noisy workplace	1.3	1.6	3.4	1.5	-0.3	1.9	1.4	0.6	0.4	1.7
Qualifications: A levels/AS levels or equivalent	0.6	1.2	2.2	0.1	0.9	-1.4	-1.0	-1.1	-1.5	-1.1
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	2.3	0.4	1.2	-0.1	-1.0	-0.9	-1.5	-0.3
Mouth/teeth dental problems: Dentures	1.0	1.7	5.6	2.4	0.6	1.5	1.1	0.6	-0.9	1.1
Asthma	2.8	5.6	9.5	-2.9	1.1	-2.6	-2.0	-3.1	-1.5	-2.7
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.4	1.2	0.6	0.4	0.3	-0.5	-0.9	0.3
Medication: Cholesterol lowering	1.1	1.7	4.8	0.2	2.2	-0.3	-0.1	-1.9	-1.9	-0.5
Depression (self-reported)	0.5	0.7	2.4	-1.5	-1.0	-0.5	-0.4	0.0	0.8	-0.4
Medication: Lansoprazole	3.4	3.9	5.9	-1.2	2.1	-2.2	-2.0	-1.8	-2.4	-1.9
Prospective memory result	1.8	2.2	3.2	1.0	-1.7	1.8	1.2	1.6	1.5	1.5
Lung cancer (father)	0.3	0.3	0.8	-0.9	-0.4	0.0	-0.2	-0.8	0.5	-0.3
Illnesses of mother	0.8	1.0	2.8	-0.2	-1.7	0.3	0.0	1.6	1.3	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	1.0	-1.0	-0.8	-0.9	-0.7	0.7	0.7	-0.6
Pulse wave Arterial Stiffness index	0.3	0.4	0.8	-0.3	-0.8	0.7	0.5	-0.4	0.9	0.3
Impedance of arm (left)	0.8	3.6	8.9	-3.0	0.3	-2.6	-1.5	-1.2	0.1	-2.4
Arm fat mass (right)	1.0	4.0	8.3	-2.9	-0.2	-1.8	-2.6	-2.0	-0.8	-2.3
Trunk predicted mass	0.4	2.5	8.2	-0.0	-2.9	1.5	-0.0	1.6	1.8	0.9
Standing height	0.9	9.0	27.4	-2.5	-5.2	1.0	-0.1	2.8	4.6	0.2
Length of working week for main job	0.2	0.2	0.9	1.0	0.2	0.1	-0.3	0.5	-0.6	0.1
Exposure to tobacco smoke at home	2.8	3.2	8.1	-0.3	-1.9	0.9	1.1	2.5	2.9	1.5
Breastfed as a baby	1.5	1.8	2.4	1.5	-1.4	1.3	1.3	1.5	1.0	1.4
Tense / ‘highly strung’	0.5	0.9	1.9	-1.4	-1.3	-0.5	-0.8	-0.5	0.6	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	1.8	2.8	4.7	-2.2	0.5	-1.7	-1.7	-2.2	-1.1	-1.8
Hair/balding pattern: Pattern 4	1.4	3.3	8.9	1.3	2.9	-1.2	-0.9	-1.3	-3.0	-0.8
Birth weight of first child	0.8	1.4	2.9	-1.2	1.2	-1.7	-1.1	-0.7	-0.9	-1.3
Peak expiratory flow (PEF)	0.1	0.3	0.9	-0.3	-0.7	-0.6	-1.0	0.2	0.2	-0.5
Pulse wave reflection index	0.7	0.8	1.8	0.2	1.2	-0.7	-0.4	-1.1	-1.3	-0.8
Ever highly irritable/argumentative for 2 days	2.2	2.7	6.0	0.3	1.5	-1.5	-1.9	-1.5	-2.4	-1.6
Loud music exposure frequency	4.5	4.9	7.6	-0.9	2.3	-2.3	-2.4	-2.0	-2.8	-2.3
Qualifications: O levels/GCSEs or equivalent	1.3	2.0	3.2	-1.0	0.7	-1.7	-1.4	-1.8	-1.4	-1.5
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.9	-0.3	-0.6	0.6	0.8	0.2	0.9	0.7
Blood clot in the leg (DVT)	0.2	0.3	0.9	0.3	-0.2	0.6	-0.2	-1.0	-0.6	-0.1
Medication: Paracetamol	0.1	0.1	0.5	-0.7	0.3	-0.3	-0.0	-0.4	0.1	-0.2
Headache pain in last month	0.2	0.3	0.7	0.1	0.5	-0.6	-0.4	-0.5	-0.6	-0.8
Medication for cholesterol, blood pressure or diabetes	1.3	2.1	5.1	-0.2	-1.9	0.4	0.7	2.2	2.3	0.9
Glaucoma (self-reported)	0.6	0.7	2.5	-0.3	0.9	-0.6	-0.3	-1.6	-0.8	-0.7
Gout (self-reported)	1.1	1.5	5.2	-2.3	-1.3	-0.8	-0.8	0.4	1.2	-0.6
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.0	-0.5	0.9	-1.0	-0.2	-0.5	-0.6	-0.6
Medication: Amlodipine	2.0	2.9	4.0	-1.3	1.4	-1.8	-1.8	-1.8	-1.6	-2.0
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.5	0.7	0.0	0.2	0.0	0.1	-0.5	0.1
Birth weight	0.3	0.7	1.9	1.4	-0.3	0.5	0.8	1.1	0.3	0.8
Chronic bronchitis/emphysema (mother)	0.3	0.3	1.1	1.1	0.1	0.2	0.7	0.3	0.0	0.6
High blood pressure (siblings)	1.1	1.6	3.2	-0.8	0.6	-1.8	-1.6	-0.8	-1.1	-1.7
Forced vital capacity (FVC), Best measure	0.2	0.8	1.6	-0.8	-1.2	-0.5	-0.2	1.3	1.3	-0.1
Body fat percentage	0.9	3.6	10.6	-3.3	-0.3	-1.5	-2.0	-2.1	-0.3	-2.0
Leg fat percentage (right)	0.7	2.7	7.1	-2.7	-0.1	-1.3	-1.8	-1.8	-0.5	-1.7
Arm fat-free mass (right)	0.5	2.6	8.4	0.2	-2.9	1.8	0.2	1.5	1.7	1.1
Exposure to tobacco smoke outside home	0.4	0.6	1.7	-0.9	-1.3	-0.4	-0.5	0.5	1.0	-0.3
Comparative body size at age 10	0.3	0.9	2.2	0.1	0.8	-0.8	-0.9	-1.0	-1.5	-1.0
Number of full brothers	0.1	0.2	0.4	-0.4	0.6	-0.4	0.1	-0.6	-0.3	0.0
Worry too long after embarrassment	2.3	3.9	6.6	-0.6	2.5	-1.7	-1.4	-2.6	-2.3	-2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	2.4	3.1	4.5	-2.1	1.2	-2.0	-1.6	-2.1	-1.2	-1.9
Wheeze or whistling in the chest in last year	2.8	5.0	10.4	-2.0	2.2	-2.1	-1.5	-3.2	-2.0	-2.1
Number of children fathered	0.6	0.7	2.3	-0.6	-1.5	0.6	-0.0	0.7	1.2	0.2
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	3.1	-1.8	-1.7	-0.8	-1.0	0.5	0.9	-0.8
Age at first live birth	0.4	0.7	2.5	-0.9	-1.6	-0.2	-0.7	0.3	0.9	-0.4
Pulse wave peak to peak time	0.2	0.2	0.4	-0.1	0.4	-0.7	-0.5	0.6	-0.5	-0.3
Health satisfaction	2.1	2.7	6.2	-0.6	2.5	-1.2	-0.7	-2.4	-2.0	-1.0
Shortness of breath walking on level ground	0.5	0.6	1.8	-1.4	0.1	-0.6	-0.7	-1.1	-0.2	-0.7
Qualifications: College or University degree	0.1	0.4	1.0	1.0	0.8	-0.4	0.0	0.3	-0.9	0.2
Eye problems/disorders: None of the above	0.3	0.3	0.7	-0.1	-0.0	-0.6	-0.7	-0.8	-0.6	-0.6
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.1	0.4	0.3	0.3	1.0	0.8	0.7	0.9
Emphysema/chronic bronchitis	0.0	0.1	0.2	-0.2	0.1	0.0	-0.1	-0.4	-0.3	-0.3
Medication for pain relief, constipation, heartburn	0.8	1.4	3.4	-1.8	-1.4	-1.1	-1.2	0.6	0.9	-0.8
Neck or shoulder pain in last month	0.0	0.0	0.1	-0.3	-0.1	0.1	-0.2	0.1	0.1	0.1
Medication: Blood pressure	0.9	1.6	2.9	-1.2	1.2	-1.1	-1.0	-1.7	-1.4	-1.1
Angina (self-reported)	0.7	0.9	1.8	1.2	1.3	0.7	0.5	-0.9	-1.2	0.2
Migraine (self-reported)	0.2	0.3	0.6	-0.0	-0.0	-0.6	-0.7	-0.5	-0.6	-0.8
Medication: Ibuprofen	0.3	0.3	0.7	0.8	0.8	-0.1	0.1	-0.4	-0.8	-0.0
Medication: Allopurinol	1.2	1.6	4.0	-0.7	-2.0	0.8	0.3	1.4	1.9	0.7
Medication: Omeprazole	0.1	0.1	0.6	-0.3	0.4	-0.0	0.3	-0.8	-0.2	-0.0
Medication: Seretide 50 evohaler	1.0	1.1	1.8	-0.6	0.6	-1.0	-1.2	-1.3	-1.1	-1.2
Mean time to correctly identify matches	0.8	1.5	2.7	0.0	-1.3	1.4	1.6	0.5	1.6	1.1
Heart disease (mother)	0.5	0.6	1.4	0.8	0.9	0.0	-0.2	-1.0	-1.2	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.8	0.2	0.5	-0.9	0.0	0.8	0.0	-0.2
Whole body fat mass	0.7	2.8	8.7	-3.0	-0.9	-1.1	-1.9	-1.5	0.1	-1.6
Leg fat mass (right)	0.7	2.7	7.4	-2.7	-0.9	-1.1	-2.2	-1.4	-0.1	-1.7
Arm predicted mass (right)	0.5	2.3	7.8	0.0	-2.8	1.6	0.0	1.4	1.7	1.0
Pulse rate, automated reading	1.3	4.3	9.4	0.5	-2.4	1.6	1.3	3.1	2.6	2.0
Alcohol intake frequency.	0.5	1.1	1.8	-1.3	-0.4	-0.6	-1.4	-1.2	-0.4	-1.3
Comparative height size at age 10	0.2	1.3	4.4	-0.3	-2.1	0.6	0.0	1.2	1.7	0.2
Number of full sisters	1.1	1.4	2.4	-1.3	-0.0	-1.6	-1.5	-0.8	-0.5	-1.5
Suffer from ‘nerves’	3.5	5.5	8.7	-2.4	0.8	-2.5	-2.8	-2.5	-1.8	-3.0
Overall health rating	0.7	1.4	3.1	-1.2	0.5	-0.9	-1.2	-1.8	-0.9	-1.4
Chest pain or discomfort	0.8	1.2	2.3	-0.3	1.5	-0.7	-0.5	-1.5	-1.5	-0.9
Had major operations	0.2	0.2	0.7	0.8	0.4	0.4	0.2	0.2	-0.5	0.5
Age at last live birth	0.8	1.1	3.6	-1.0	-1.9	0.2	-0.0	0.6	1.7	-0.1
Family relationship satisfaction	0.2	0.3	1.2	0.3	1.1	-0.3	0.5	0.0	-0.4	0.2
Leg pain on walking	0.2	0.2	0.5	-0.7	-0.7	0.2	-0.3	0.2	0.5	-0.3
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.4	3.6	-1.9	-0.2	-1.6	-1.1	-0.6	0.4	-1.5
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.3	-0.1	-0.1	-0.2	-0.5	-0.6	-0.5	-0.2
Illness, injury, bereavement, stress in last 2 years	1.1	1.3	2.7	1.3	-0.5	0.6	1.6	1.5	0.9	1.1
Medication: Aspirin	1.1	1.4	4.4	1.0	1.5	-0.6	-0.7	-1.0	-2.1	-0.7
Supplements: Vitamin C	0.8	1.0	2.2	-0.9	0.1	-1.1	-1.5	-0.9	-0.9	-1.2
Knee pain experienced in last month	0.5	0.8	2.7	-0.7	-1.7	0.4	-0.6	0.7	1.3	-0.1
Hypertension (Self-reported)	2.5	7.1	10.8	-1.7	2.5	-2.5	-2.5	-3.3	-3.0	-2.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.7	4.8	0.7	1.7	-0.4	-0.3	-1.7	-2.2	-0.4
Illnesses of father: Heart disease	1.5	2.1	5.1	0.4	1.5	-1.2	-1.5	-1.2	-2.3	-1.4
Illnesses of siblings: Diabetes	0.0	0.0	0.0	-0.2	0.1	-0.0	-0.1	0.2	0.1	0.0
Smoking status: Previous	0.0	0.0	0.1	0.2	-0.2	0.3	0.1	0.1	-0.1	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.1	0.4	-0.3	-0.6	-0.2	-0.4	-0.3	-0.1	-0.5
Whole body fat-free mass	0.3	1.6	6.7	-0.6	-2.6	0.9	-0.6	1.0	1.4	0.3
Leg fat-free mass (right)	0.2	1.1	3.1	-1.2	-1.8	-0.1	-1.5	-0.2	0.4	-0.8
Arm fat percentage (left)	1.2	4.9	7.2	-2.7	0.9	-2.1	-2.5	-2.7	-1.6	-2.4
Average weekly red wine intake	2.2	3.3	5.7	-2.2	0.9	-2.4	-2.0	-1.8	-0.9	-2.0
Handedness (chirality/laterality): Left-handed	0.0	0.1	0.1	-0.1	-0.1	-0.3	-0.2	-0.3	-0.2	-0.3
Mood swings	1.5	2.7	5.4	-2.3	-0.6	-1.5	-2.1	-1.5	-0.0	-2.1
Loneliness, isolation	4.0	5.6	10.6	-3.3	0.7	-2.5	-2.7	-2.3	-0.9	-2.9
Long-standing illness, disability or infirmity	0.2	0.2	0.7	0.4	0.2	0.7	0.0	-0.5	-0.9	-0.1
Ever had bowel cancer screening	0.5	0.6	0.8	0.4	-0.9	0.9	0.7	0.9	0.8	0.5
Diabetes diagnosed by doctor	0.1	0.2	0.7	0.2	0.8	0.0	0.4	-0.2	-0.5	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	2.3	1.5	0.8	0.6	0.9	0.5	-0.4	1.0
Friendships satisfaction	0.3	0.4	1.0	0.6	1.0	-0.8	-0.2	0.1	-1.0	-0.4
Qualifications: nursing, teaching	0.2	0.3	1.3	0.4	0.6	-1.2	-0.3	0.3	-0.5	-0.3
Commuting to job workplace: Walk	0.4	0.4	0.9	-0.6	0.1	-0.7	-0.9	-0.2	-0.4	-0.9
Eye problems/disorders: Cataract	0.1	0.1	0.2	-0.5	0.3	-0.3	-0.4	0.0	-0.2	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	3.2	1.8	0.3	0.7	-0.2	0.2	-1.1	0.1
Medication for cholesterol	1.6	2.4	5.8	0.2	-1.8	1.0	1.3	1.8	2.4	1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.9	3.5	5.3	-0.8	1.8	-1.7	-1.7	-2.3	-2.2	-2.1
Back pain experienced in last month	0.7	1.0	2.2	1.5	-0.2	1.2	1.0	1.0	0.3	0.9
Mineral and other dietary supplements	0.5	0.7	1.6	0.7	1.3	-0.1	0.2	-1.1	-1.2	-0.0
Breast cancer (self-reported)	1.0	1.2	3.8	-1.9	-0.8	-1.3	-0.6	-0.0	0.9	-1.0
Asthma (self-reported)	2.2	4.3	7.6	-2.8	1.0	-2.3	-1.7	-2.7	-1.1	-2.4
Osteoporosis (self-reported)	0.3	0.4	1.1	0.8	1.0	-0.2	0.4	0.8	-0.3	0.3
Osteoarthritis (self-reported)	0.2	0.2	0.4	-0.5	-0.6	0.5	0.1	0.3	0.7	0.2
Medication: Aspirin	1.4	1.8	5.1	0.6	1.8	-0.9	-0.8	-1.3	-2.2	-1.0
Medication: Gliclazide	0.6	0.6	2.4	1.6	0.2	0.4	0.3	1.0	-0.6	0.6
Illnesses of father: None of the above (group 1)	3.7	4.6	6.2	0.9	-1.6	2.1	2.5	2.5	2.5	2.5
Smoking status: Current	0.3	0.4	1.2	0.4	-0.0	0.4	0.6	1.1	0.8	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.8	-0.6	0.2	-0.9	-0.3	0.6	0.1	-0.1
Whole body water mass	0.3	1.6	6.7	-0.4	-2.6	1.1	-0.5	1.0	1.4	0.4
Leg predicted mass (right)	0.2	1.1	3.2	-1.3	-1.8	-0.1	-1.4	-0.2	0.5	-0.8
Arm fat mass (left)	0.7	2.8	6.1	-2.5	-0.4	-1.4	-2.2	-1.7	-0.7	-1.9
Number of self-reported non-cancer illnesses	1.0	1.8	3.3	-0.4	1.6	-1.0	-0.9	-1.6	-1.8	-1.4
Average weekly champagne plus white wine intake	0.1	0.2	0.4	0.5	0.1	0.4	0.6	-0.1	-0.0	0.5
Miserableness	0.5	0.9	1.6	-1.3	-0.8	-0.5	-1.2	-0.5	0.5	-1.2
Guilty feelings	1.3	1.9	4.1	-0.1	1.6	-1.5	-1.0	-1.5	-2.0	-1.1
Wears glasses or contact lenses	0.5	0.6	1.3	0.7	1.1	0.4	-0.2	-0.9	-1.1	-0.3
Ever taken oral contraceptive pill	0.8	0.8	1.9	-1.0	-0.3	-0.9	-1.4	-0.7	-0.4	-1.2
Hearing aid user	0.9	1.0	2.0	-0.5	0.6	-1.4	-1.4	-0.4	-1.0	-1.2
Mother’s age at death	3.5	4.4	8.6	-0.1	-2.9	1.7	1.3	2.7	2.9	1.5
Financial situation satisfaction	0.7	0.8	2.0	-0.1	1.4	-0.6	-0.2	-1.1	-1.3	-0.7
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.1	0.9	-0.6	1.1	1.0	0.9	0.8	0.9
Commuting to job workplace: Public transport	1.2	1.4	2.0	-0.7	1.0	-1.3	-1.4	-1.1	-1.3	-1.4
Eye problems/disorders: Glaucoma	0.3	0.4	0.9	-0.9	0.1	-0.5	-0.5	-0.9	-0.2	-0.7
Medication: Blood pressure	1.8	3.4	6.6	-0.0	2.0	-1.2	-1.6	-2.4	-2.6	-1.8
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.6	0.3	0.1	-0.4	-0.8	-0.1	-0.7	-0.7
Supplements: Fish oil (including cod liver oil)	0.0	0.0	0.1	-0.2	0.1	-0.0	-0.3	-0.1	-0.1	-0.3
High cholesterol (Self-reported)	1.3	2.3	6.8	0.8	2.6	-0.6	-0.4	-1.3	-2.5	-0.5
Medication: Bendroflumethiazide	1.7	2.6	4.9	-0.4	2.2	-1.9	-1.4	-1.4	-2.0	-1.3
Medication: Paracetamol	0.4	0.7	1.1	-0.6	1.1	-1.0	-0.5	-1.0	-0.7	-0.8
Medication: Lisinopril	0.8	1.0	2.7	-0.1	1.6	-0.4	-0.2	-1.4	-1.5	-0.5
Medication: Atorvastatin	0.4	0.4	1.8	0.3	1.4	-0.1	0.4	-0.1	-0.9	0.3
Illnesses of father: High blood pressure	7.4	9.1	13.3	-2.7	1.8	-3.0	-3.4	-3.6	-2.4	-3.6
Alcohol drinker status: Never	2.1	2.5	5.4	-0.2	1.6	-0.9	-1.3	-2.3	-2.2	-1.4
Ever smoked	0.3	0.5	1.4	-0.1	-0.5	0.7	0.4	1.2	1.0	0.5
Basal metabolic rate	0.3	1.6	6.3	-1.2	-2.5	0.5	-1.0	0.5	1.3	-0.2
Leg fat percentage (left)	0.6	2.3	7.2	-2.7	-0.8	-1.0	-1.7	-1.5	0.1	-1.5
Arm fat-free mass (left)	0.5	2.6	9.4	-0.7	-3.1	1.4	-0.1	1.3	2.1	0.7
Number of operations (self-reported)	0.2	0.3	1.0	0.4	-0.3	0.5	0.4	1.0	0.3	0.3
Average weekly beer plus cider intake	0.9	1.2	3.2	-0.3	-1.8	1.0	0.4	1.2	1.6	0.6
Irritability	0.1	0.2	0.5	-0.4	-0.6	-0.3	-0.6	-0.2	0.2	-0.7
Risk taking	0.3	0.4	1.1	0.2	0.9	-0.3	-0.1	-1.1	-0.8	-0.2
Ever had prostate specific antigen (PSA) test	1.4	1.6	3.1	-0.3	1.8	-1.1	-1.0	-1.6	-1.6	-0.8
Fractured/broken bones in last 5 years	0.4	0.5	2.0	1.4	0.4	0.6	0.2	-0.2	-0.9	0.2
Age started oral contraceptive pill	1.2	1.5	3.8	0.2	-1.6	0.5	0.8	1.9	1.7	0.8
Diastolic blood pressure, automated reading	1.4	4.2	6.2	-1.9	0.9	-2.3	-2.2	-2.5	-1.7	-2.4
Ever depressed for a whole week	2.5	3.1	7.6	0.5	2.8	-1.1	-0.7	-2.0	-2.6	-1.2
Unable to work because of sickness or disability	1.9	2.4	5.4	1.5	-0.2	2.2	2.3	0.7	0.9	1.8
Commuting to job workplace: Cycle	1.0	1.2	3.3	0.9	-1.3	0.5	0.8	1.8	1.2	0.5
Myopia	3.3	4.8	10.1	-0.8	2.4	-1.9	-1.5	-3.2	-2.7	-1.9
Vascular/heart problems diagnosed by doctor	2.1	5.7	10.2	0.8	-2.4	1.7	2.1	3.2	3.2	2.5
Cholesterol lowering medication	1.3	2.0	5.0	0.4	2.2	-1.1	-0.9	-0.9	-2.2	-0.9
Medication: Omeprazole (e.g. Zanprol)	0.4	0.4	1.7	-0.6	0.7	-0.3	-0.0	-1.3	-0.5	-0.3
Pain experienced in last month	0.2	0.4	0.9	0.8	-0.0	0.4	1.0	0.3	0.1	0.9
Supplements: Calcium	0.6	0.6	1.8	-0.6	-0.7	-0.1	0.5	1.1	1.3	0.2
Basal cell carcinoma (self-reported)	0.2	0.2	1.1	-1.0	-0.1	-0.3	-0.2	-0.4	0.3	-0.3
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.5	-1.2	-0.2	-0.5	-0.8	-0.3	0.1	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.3	0.4	0.1	0.6	-0.2	-1.2	-0.9	-0.1
Heart disease (siblings)	0.1	0.1	0.5	-0.1	0.3	-0.7	-0.2	0.2	-0.2	-0.2
Alcohol drinker status: Previous	1.8	2.0	6.3	-2.5	-0.7	-1.3	-1.4	-0.9	0.2	-1.6
Pack years of smoking	2.6	3.8	6.9	1.2	-1.2	1.8	2.2	2.6	2.0	2.1
Impedance of whole body	0.5	2.7	9.8	-3.1	-1.0	-1.6	-0.7	-0.1	1.6	-1.5
Leg fat mass (left)	0.6	2.4	7.0	-2.6	-1.2	-0.9	-2.0	-1.3	0.2	-1.5
Arm predicted mass (left)	0.5	2.6	9.0	-0.4	-3.0	1.5	-0.1	1.4	2.0	0.8