Hub : Genes

TFCP2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Lung 0.0773 0.0355 8.8e-03 0.016 NA 0.020 NA 0.023 1.9e-02 NA 1.1e-02 NA 6.5e-03
2 GTEx Muscle Skeletal 0.0499 0.0249 9.1e-03 0.011 NA 0.001 NA 0.004 2.5e-02 NA 2.6e-01 NA 1.2e-01
3 ROSMAP Brain Pre-frontal Cortex 0.1115 0.0336 7.7e-07 0.062 0.063 0.061 0.075 0.077 2.0e-08 1.7e-08 2.5e-08 6.5e-10 4.3e-10
4 YFS Blood 0.3580 0.0371 0.0e+00 0.323 0.313 0.344 0.339 0.342 3.7e-109 3.8e-105 1.0e-117 9.1e-116 7.4e-117
5 TCGA Brain Lower Grade Glioma 0.0292 0.0166 6.8e-03 0.006 0.008 0.005 NA 0.003 6.1e-02 3.8e-02 8.6e-02 NA 1.3e-01
6 TCGA Prostate Adenocarcinoma 0.0304 0.0173 7.8e-03 0.020 0.024 0.019 NA 0.017 3.4e-03 1.4e-03 3.9e-03 NA 6.2e-03
7 TCGA Thyroid Carcinoma 0.0540 0.0270 2.4e-03 0.049 0.016 0.032 NA 0.047 1.6e-05 9.1e-03 3.7e-04 NA 2.1e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.2 0.3 0.7 -0.5 -0.1 -0.5 -0.8 -0.8 -0.1 -0.4
Bipolar Disorder or Schizophrenia 0.2 0.5 1.6 -1.3 -0.0 -0.6 -0.6 -1.1 0.2 -0.2
Depressed Affect (Nagel 2018) 1.3 2.8 5.7 -2.2 -0.6 -1.4 -2.3 -1.3 -0.1 -2.4
Depression (Nagel 2018) 0.1 0.1 0.4 -0.1 -0.6 0.3 0.0 -0.2 0.1 0.1
Intelligence (Savage-Jansen 2018) 0.8 2.5 6.6 0.2 2.6 -1.2 -0.5 -1.6 -2.4 -0.8
Neuroticism (Nagel 2018) 1.6 3.8 7.2 -2.1 0.4 -1.9 -2.3 -2.2 -1.1 -2.7
Schizophrenia (2018) 0.2 0.3 1.5 -1.2 0.0 -0.4 -0.2 -0.7 0.3 -0.0
Schizophrenia vs Biploar Disorder 3.0 3.9 8.2 -0.2 -1.8 1.6 2.3 2.1 2.9 1.9
Worry (Nagel 2018) 0.9 1.9 3.8 -1.6 0.1 -1.1 -1.4 -2.0 -0.9 -1.7
Alzheimer’s Disease (in mother) 1.0 1.2 3.4 -1.9 0.4 -1.4 -1.1 -0.5 -0.2 -1.2
Alzheimer’s Disease (in father) 0.3 0.3 0.7 -0.6 0.0 -0.8 -0.5 -0.6 -0.3 -0.8
Alzheimer’s Disease (including proxy) 1.0 1.4 3.4 -1.8 0.3 -1.8 -1.0 -0.7 -0.4 -1.3
Crohns Disease (2017) 1.5 3.2 8.8 -1.6 -2.4 0.6 0.6 2.1 3.0 0.8
Irritable Bowel Disease (IBD) 0.8 1.8 3.5 0.2 -1.4 1.2 1.0 1.9 1.7 1.4
Ulcerative Colitis (UC) 0.8 1.6 2.8 1.6 -0.4 1.7 1.2 1.2 0.2 1.6
Major Depression (MDD) 0.1 0.1 0.5 -0.3 0.7 -0.3 0.0 -0.3 -0.2 -0.4
Reaction Time 0.2 0.4 0.9 -0.3 -0.6 0.9 1.0 -0.4 0.7 0.4
Verbal and Numeric Reasoning (VNR) 1.2 3.0 6.9 0.1 2.6 -1.2 -0.8 -1.9 -2.6 -1.1
Breast Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Ovarian Cancer 0.2 0.3 0.6 -0.8 -0.6 -0.3 -0.6 -0.5 0.1 -0.5
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 1.1 1.6 5.0 0.6 -2.2 1.3 0.5 1.4 1.2 0.8
Bipolar Disorder (2011) 2.9 2.8 4.2 -1.1 1.3 -1.9 -1.9 -2.1 -1.9 -1.5
Body Mass Index (BMI) (2010) 0.4 0.5 1.4 0.7 0.7 -0.3 -0.3 -0.9 -1.2 -0.2
Coronary Artery Disease (CAD) 0.7 0.8 2.8 0.4 1.7 -0.3 0.0 -0.8 -1.4 0.0
Crohns Disease (2012) 0.6 0.9 2.3 -0.5 -1.1 0.2 0.2 1.5 1.4 0.5
Mean Putamen Volume 2.6 3.0 4.5 -2.0 0.3 -1.8 -2.0 -2.1 -1.0 -1.9
Fasting Glucose 0.4 0.5 1.2 -0.0 0.6 -0.7 -1.0 -0.2 -0.7 -1.1
HbA1C 2.7 2.9 8.0 1.4 2.8 -0.6 -0.3 -1.9 -2.5 -0.4
HDL Cholesterol 0.2 0.4 1.0 -0.6 0.9 -0.6 -0.2 -1.0 -0.4 -0.4
LDL Cholesterol 0.4 0.7 2.1 1.4 1.2 0.4 0.6 0.5 -0.6 0.5
Lupus 1.0 1.5 2.2 0.9 -1.2 1.2 1.5 1.0 1.3 1.5
Neuroticism (2016) 1.1 1.6 3.9 -1.3 -0.3 -1.2 -1.5 -1.1 -0.7 -2.0
Primary Biliary Cirrhosis 2.2 3.1 5.6 -1.6 1.3 -1.9 -1.5 -2.4 -1.7 -1.8
Rheumatoid Arthritis 1.8 2.5 5.7 -2.4 -0.6 -1.9 -1.9 -0.3 0.6 -1.9
Schizophrenia (2014) 0.4 0.8 2.5 -1.6 0.5 -1.2 -0.7 -0.9 -0.1 -0.5
Triglycerides 1.3 2.2 4.7 2.2 1.5 1.2 1.9 0.5 -0.7 1.6
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.2 0.1 -0.5 0.1 0.3 0.3 0.2 0.2
Ulcerative Colitis 0.7 1.0 3.7 1.9 0.3 1.2 0.5 0.2 -0.8 1.1
Blood Eosinophil Count 1.0 7.5 22.3 0.3 4.7 -1.7 -0.5 -3.5 -3.6 -0.9
Blood Platelet Count 0.8 9.7 20.0 -0.2 4.5 -2.3 -2.3 -4.0 -4.2 -2.0
Blood Red Count 0.6 6.2 10.3 1.3 -2.9 2.5 1.8 3.2 2.9 2.3
Blood White Count 1.9 13.8 42.0 -0.4 6.5 -3.6 -1.1 -3.7 -4.9 -1.6
Heel T-Score 0.8 6.2 19.1 -4.4 -2.9 -1.9 -1.5 0.1 2.6 -1.8
BMI 0.5 2.8 5.2 -1.9 0.2 -1.4 -2.3 -2.0 -1.3 -1.8
Height 0.8 16.1 48.8 -2.7 -7.0 1.4 0.1 4.2 6.1 0.5
Waist Hip Ratio (WHR) 0.8 3.6 9.2 3.0 2.0 1.4 1.9 -0.7 -1.9 1.6
Systolic Blood Pressure 0.6 3.1 4.4 -0.7 2.0 -1.9 -1.2 -2.1 -2.1 -1.8
Smoking Status 0.0 0.1 0.2 0.0 0.5 -0.1 0.2 0.3 0.1 0.2
Allergy or Eczema 0.7 1.8 4.4 0.5 -1.4 0.6 1.2 2.1 1.8 0.9
Cardiovascular Disease 2.2 7.2 13.3 -0.9 2.9 -2.0 -2.2 -3.5 -3.6 -2.6
Hypothyroidism (self reported) 0.0 0.1 0.2 -0.1 0.4 -0.5 0.2 -0.1 -0.3 -0.3
Respiratory disease 2.0 4.4 7.3 -2.2 1.3 -2.2 -1.9 -2.7 -1.7 -2.3
Type 2 Diabetes (T2D) (2018) 0.6 1.1 2.4 1.4 0.7 1.0 1.6 0.2 -0.2 1.4
Lung FEV1/FVC ratio 0.0 0.1 0.3 -0.6 -0.1 -0.2 -0.3 -0.3 -0.0 -0.5
Lung FVC 0.2 0.9 2.4 1.6 1.4 -0.1 0.1 0.5 -1.1 0.3
Neuroticism 2.4 5.8 10.0 -2.0 1.0 -2.4 -3.0 -2.7 -2.1 -3.2
Chronotype (morning person) 0.7 1.6 5.2 0.6 -2.3 1.0 -0.3 1.9 0.8 0.5
Hair Pigment 0.0 1.2 3.6 1.9 0.8 1.3 1.1 -0.3 -0.9 0.7
Tanning 0.1 1.4 3.4 1.8 -0.7 1.6 0.7 0.9 0.1 1.4
Hand grip strength (left) 1.3 3.4 9.6 1.5 -1.5 1.1 1.3 3.1 1.7 1.8
Number of treatments/medications taken 1.6 2.9 6.0 -0.0 2.3 -1.0 -1.0 -2.4 -2.4 -1.3
Average weekly spirits intake 0.2 0.2 0.6 0.7 0.6 0.7 -0.0 -0.0 -0.5 0.1
Sensitivity / hurt feelings 2.1 3.5 6.8 -1.6 1.3 -1.9 -1.7 -2.6 -1.7 -2.1
Frequency of depressed mood in last 2 weeks 0.3 0.4 1.7 -0.8 -1.3 0.3 -0.4 -0.5 0.4 -0.2
Hearing difficulty/problems: Yes 1.2 1.9 3.2 -1.1 1.6 -1.8 -1.1 -1.2 -1.3 -1.4
Relative age of first facial hair 0.3 0.6 1.0 0.9 -0.3 0.8 1.0 0.8 0.6 0.8
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 2.5 0.7 1.2 0.4 -0.3 -0.6 -1.6 -0.5
Ever used hormone-replacement therapy (HRT) 0.1 0.1 0.4 -0.3 -0.2 -0.0 -0.7 -0.2 -0.3 -0.3
Ever had hysterectomy (womb removed) 0.7 0.8 2.0 -0.7 -1.1 -0.3 -0.2 1.4 1.2 -0.2
Systolic blood pressure, automated reading 0.7 2.1 2.8 -0.8 1.4 -1.7 -1.2 -1.6 -1.6 -1.6
Eye problems/disorders: Diabetes related eye disease 0.4 0.4 1.3 0.1 -0.1 0.2 0.7 1.1 0.6 0.7
Angina 0.9 1.2 3.1 1.8 1.2 1.2 0.9 -0.5 -1.0 0.8
Medication for hormone replacement therapy 1.5 1.7 2.7 -1.4 0.1 -1.2 -1.6 -1.4 -1.3 -1.5
Vitamin and mineral supplements 1.3 1.8 4.0 1.8 0.2 1.2 2.0 1.0 0.6 1.6
Supplements: Zinc 0.2 0.2 0.8 -0.2 -0.3 -0.1 0.2 0.9 0.6 0.6
Medication: Co-codamol 0.5 0.6 2.1 0.1 -1.4 1.0 0.2 0.7 0.6 0.4
Medication: Metformin 0.1 0.2 0.6 0.4 0.8 -0.1 0.3 0.2 -0.5 0.3
Diabetes (father) 0.4 0.5 0.9 -0.3 0.6 -0.7 -0.6 -0.9 -0.9 -0.8
Diabetes (mother) 0.2 0.2 0.5 0.1 0.5 -0.2 -0.5 -0.7 -0.6 -0.3
Severe depression (siblings) 3.7 4.1 11.1 1.9 3.3 -0.3 -0.0 -2.2 -3.1 -0.0
Pack years adult smoking proportion 2.9 4.4 7.8 1.4 -1.3 1.9 2.4 2.8 2.1 2.3
Impedance of leg (right) 0.3 1.6 4.4 -2.1 -1.4 -0.3 0.3 0.7 2.1 -0.3
Leg fat-free mass (left) 0.2 1.2 2.8 -1.5 -1.5 -0.4 -1.7 -0.4 0.2 -1.0
Trunk fat percentage 1.0 4.0 12.2 -3.5 -0.5 -1.6 -2.1 -2.0 -0.2 -2.1
Hand grip strength (right) 1.3 3.6 8.7 1.4 -1.6 1.3 1.6 3.0 1.9 2.1
Townsend deprivation index at recruitment 1.6 2.2 6.4 -1.8 -2.5 0.3 0.0 0.9 2.2 0.0
Current tobacco smoking 0.1 0.1 0.5 -0.0 0.1 0.1 0.3 0.7 0.6 0.2
Average weekly fortified wine intake 0.6 0.7 1.8 1.4 1.0 0.7 0.6 -0.3 -1.0 0.5
Maternal smoking around birth 0.1 0.2 0.5 -0.6 -0.3 0.3 0.5 0.3 0.7 0.3
Fed-up feelings 0.5 0.9 2.5 -0.7 -0.4 -0.8 -1.6 -0.7 -0.6 -1.4
Frequency of unenthusiasm / disinterest in last 2 weeks 1.0 1.4 3.8 -0.4 -1.9 1.0 0.7 0.7 1.7 1.0
Relative age voice broke 0.3 0.4 1.0 1.0 0.7 0.4 0.9 0.0 -0.0 0.6
Taking other prescription medications 1.0 1.6 3.5 0.3 1.8 -0.3 -0.3 -1.8 -1.9 -0.9
Age when periods started (menarche) 0.4 0.9 3.2 -1.8 -0.4 -0.9 -0.3 -0.8 0.7 -1.0
Bilateral oophorectomy (both ovaries removed) 0.8 0.9 3.1 -1.0 -1.8 -0.0 -0.4 0.9 1.1 0.0
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.3 2.9 -1.7 -0.3 -1.3 -1.2 -0.9 0.0 -1.5
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.8 -0.9 0.5 -0.1 0.1 -0.7 0.1 0.1
Qualifications: CSEs or equivalent 0.5 0.7 1.7 -1.3 -0.4 -0.4 -0.9 -1.1 -0.3 -0.8
Serious illness, injury or assault to yourself 3.1 3.7 6.2 -1.5 1.1 -1.4 -2.5 -2.2 -2.0 -2.3
High blood pressure 2.4 6.6 11.1 -1.1 2.5 -2.1 -2.3 -3.3 -3.2 -2.7
Hayfever, allergic rhinitis or eczema 0.5 1.1 2.5 -1.0 -1.5 -0.6 -0.1 1.4 1.6 -0.3
Multivitamins +/- minerals 0.8 1.0 3.9 -2.0 -0.5 -0.8 -1.1 -0.1 0.6 -1.0
Stomach or abdominal pain in last month 0.5 0.6 1.9 -1.2 -1.4 0.3 -0.4 -0.4 0.8 -0.4
Supplements: Glucosamine 1.2 1.5 4.5 -1.2 -2.1 0.6 -0.3 1.0 1.8 0.1
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 1.8 0.3 0.8 1.0 1.3 0.1 0.6 1.1
Medication: Atenolol 0.4 0.5 1.5 0.8 -0.5 1.2 0.7 0.3 0.5 0.8
Medication: Levothyroxine sodium 1.0 1.6 3.6 -1.1 1.2 -1.9 -1.2 -0.9 -1.1 -1.4
Sitting height 0.6 3.9 14.4 -1.5 -3.8 0.7 -0.8 2.0 2.5 -0.0
Chronic bronchitis/emphysema (father) 0.8 0.9 2.2 -1.5 0.7 -0.8 -0.9 -1.1 -0.5 -0.8
High blood pressure (mother) 3.2 4.5 10.2 0.4 2.9 -1.1 -1.3 -2.9 -3.2 -1.4
Body mass index (BMI) 0.4 1.9 3.7 -1.3 0.4 -0.9 -1.8 -1.9 -1.4 -1.3
Impedance of leg (left) 0.6 2.7 7.8 -2.1 -2.2 0.1 0.5 1.1 2.8 -0.1
Leg predicted mass (left) 0.2 1.2 2.8 -1.4 -1.4 -0.4 -1.7 -0.5 0.1 -1.0
Trunk fat mass 0.7 2.9 9.8 -3.1 -1.3 -1.0 -1.8 -1.3 0.4 -1.6
Waist circumference 0.1 0.3 1.0 -0.8 -0.3 0.3 -0.6 -1.0 -0.4 -0.3
Number of incorrect matches in round 0.9 1.4 2.1 0.9 -1.0 1.2 1.4 1.1 1.4 1.4
Past tobacco smoking 0.1 0.2 0.6 -0.2 0.1 -0.5 -0.4 -0.8 -0.4 -0.4
Alcohol usually taken with meals 0.8 1.2 3.1 0.8 1.7 -0.7 -0.2 -1.2 -1.7 -0.2
Nervous feelings 1.2 2.3 3.6 -1.5 0.3 -1.5 -1.9 -1.7 -1.2 -1.9
Frequency of tenseness / restlessness in last 2 weeks 2.4 3.7 7.3 -1.7 1.2 -1.6 -2.0 -2.7 -2.0 -2.0
Hearing difficulty/problems with background noise 1.0 1.6 2.4 -1.0 1.6 -1.5 -0.8 -1.4 -1.3 -1.1
Hair/balding pattern: Pattern 2 0.5 0.6 1.8 1.3 0.6 1.0 0.8 -0.5 -0.4 0.6
Had menopause 0.2 0.2 0.5 0.7 0.4 0.5 0.5 0.3 -0.2 0.2
Had other major operations 3.2 3.9 8.6 1.0 -1.4 1.7 2.1 2.9 2.2 2.0
Forced vital capacity (FVC) 0.4 1.4 2.8 -1.1 -1.7 -0.7 -0.7 1.5 1.5 -0.4
Heel bone mineral density (BMD) T-score, automated (right) 1.3 3.0 7.7 -2.8 0.1 -2.1 -1.8 -1.1 -0.0 -2.0
Ever unenthusiastic/disinterested for a whole week 3.3 4.0 9.4 0.6 3.1 -1.3 -0.8 -2.5 -2.8 -1.3
Qualifications: None of the above 0.6 1.4 3.9 1.0 -0.6 2.0 1.1 0.8 0.9 1.2
Financial difficulties in last 2 years 1.3 1.8 4.8 -2.2 -0.3 -1.0 -1.4 -1.3 0.1 -1.7
Mouth/teeth dental problems 0.9 1.4 4.2 -2.1 -0.0 -1.5 -1.0 -0.7 0.5 -1.1
Heart attack 0.4 0.5 1.7 -1.3 -0.1 -0.6 -0.9 -0.5 0.1 -0.5
Allergy 1.1 2.5 5.2 2.3 0.2 2.0 1.6 1.2 0.1 2.0
Pain all over the body in last month 0.6 0.7 2.3 -0.4 1.1 -0.1 -0.2 -1.5 -1.0 -0.4
Diabetes (self-reported) 0.1 0.1 0.2 0.4 0.4 0.3 0.4 0.2 -0.3 0.5
Hayfever/allergic rhinitis (self-reported) 1.0 1.4 3.0 -1.3 0.8 -1.7 -1.3 -0.8 -0.6 -1.4
Medication: Ramipril 0.5 0.7 2.9 0.3 0.4 0.2 -0.4 -1.7 -1.1 -0.3
Medication: Simvastatin 1.4 2.1 5.9 0.9 2.4 -0.2 -0.4 -1.5 -2.3 -0.6
Fluid intelligence score 1.3 2.7 3.9 -1.0 1.9 -1.8 -1.3 -1.6 -2.0 -1.6
Illnesses of siblings 0.5 0.8 1.6 0.8 -0.3 1.3 1.1 0.2 0.5 1.1
Neuroticism score 1.6 3.3 5.9 -1.7 0.3 -1.7 -2.2 -2.2 -1.3 -2.4
Weight 0.4 2.1 5.6 -2.4 -2.0 -0.4 -1.7 -0.5 0.8 -1.2
Impedance of arm (right) 1.1 5.0 12.6 -3.5 0.4 -3.0 -1.9 -1.5 0.0 -2.8
Arm fat percentage (right) 1.5 5.8 9.5 -3.1 0.9 -2.3 -2.7 -2.8 -1.6 -2.7
Trunk fat-free mass 0.4 2.5 8.3 -0.0 -2.9 1.6 0.1 1.6 1.9 0.9
Hip circumference 0.7 3.0 9.6 -3.1 -2.3 -0.3 -1.6 -0.7 1.3 -1.1
Time employed in main current job 0.3 0.3 1.3 1.1 0.3 0.2 0.1 0.2 -0.6 0.4
Alcohol intake versus 10 years previously 0.2 0.3 0.9 0.7 0.2 0.3 -0.2 -0.9 -0.8 -0.2
Father’s age at death 0.6 0.8 2.1 -1.5 -1.3 -0.5 -0.9 0.4 0.6 -0.5
Worrier / anxious feelings 0.6 1.1 4.9 -0.5 0.8 -0.3 -0.4 -2.2 -1.0 -0.8
Frequency of tiredness / lethargy in last 2 weeks 2.1 3.5 8.4 -2.9 -0.8 -1.5 -2.1 -1.8 -0.1 -2.3
Falls in the last year 0.2 0.3 1.4 -1.2 0.2 -0.7 -0.4 0.0 0.3 -0.4
Hair/balding pattern: Pattern 3 0.3 0.4 1.0 -0.3 0.6 -1.0 -0.8 0.4 -0.2 -0.6
Number of live births 2.2 3.1 7.8 -0.5 -1.4 1.4 2.2 1.2 2.8 1.7
Forced expiratory volume in 1-second (FEV1) 0.3 1.1 2.5 -1.0 -1.6 -0.4 -0.6 1.2 1.4 -0.3
Pulse rate 0.3 0.5 1.4 -0.4 -1.2 0.3 -0.2 0.6 1.1 0.5
Happiness 0.1 0.2 0.3 0.2 -0.2 0.6 0.6 0.1 0.4 0.5
Noisy workplace 1.3 1.6 3.4 1.5 -0.3 1.9 1.4 0.6 0.4 1.7
Qualifications: A levels/AS levels or equivalent 0.6 1.2 2.2 0.1 0.9 -1.4 -1.0 -1.1 -1.5 -1.1
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 2.3 0.4 1.2 -0.1 -1.0 -0.9 -1.5 -0.3
Mouth/teeth dental problems: Dentures 1.0 1.7 5.6 2.4 0.6 1.5 1.1 0.6 -0.9 1.1
Asthma 2.8 5.6 9.5 -2.9 1.1 -2.6 -2.0 -3.1 -1.5 -2.7
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 1.4 1.2 0.6 0.4 0.3 -0.5 -0.9 0.3
Medication: Cholesterol lowering 1.1 1.7 4.8 0.2 2.2 -0.3 -0.1 -1.9 -1.9 -0.5
Depression (self-reported) 0.5 0.7 2.4 -1.5 -1.0 -0.5 -0.4 0.0 0.8 -0.4
Medication: Lansoprazole 3.4 3.9 5.9 -1.2 2.1 -2.2 -2.0 -1.8 -2.4 -1.9
Prospective memory result 1.8 2.2 3.2 1.0 -1.7 1.8 1.2 1.6 1.5 1.5
Lung cancer (father) 0.3 0.3 0.8 -0.9 -0.4 0.0 -0.2 -0.8 0.5 -0.3
Illnesses of mother 0.8 1.0 2.8 -0.2 -1.7 0.3 0.0 1.6 1.3 0.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.6 1.0 -1.0 -0.8 -0.9 -0.7 0.7 0.7 -0.6
Pulse wave Arterial Stiffness index 0.3 0.4 0.8 -0.3 -0.8 0.7 0.5 -0.4 0.9 0.3
Impedance of arm (left) 0.8 3.6 8.9 -3.0 0.3 -2.6 -1.5 -1.2 0.1 -2.4
Arm fat mass (right) 1.0 4.0 8.3 -2.9 -0.2 -1.8 -2.6 -2.0 -0.8 -2.3
Trunk predicted mass 0.4 2.5 8.2 -0.0 -2.9 1.5 -0.0 1.6 1.8 0.9
Standing height 0.9 9.0 27.4 -2.5 -5.2 1.0 -0.1 2.8 4.6 0.2
Length of working week for main job 0.2 0.2 0.9 1.0 0.2 0.1 -0.3 0.5 -0.6 0.1
Exposure to tobacco smoke at home 2.8 3.2 8.1 -0.3 -1.9 0.9 1.1 2.5 2.9 1.5
Breastfed as a baby 1.5 1.8 2.4 1.5 -1.4 1.3 1.3 1.5 1.0 1.4
Tense / ‘highly strung’ 0.5 0.9 1.9 -1.4 -1.3 -0.5 -0.8 -0.5 0.6 -0.9
Seen doctor (GP) for nerves, anxiety, tension or depression 1.8 2.8 4.7 -2.2 0.5 -1.7 -1.7 -2.2 -1.1 -1.8
Hair/balding pattern: Pattern 4 1.4 3.3 8.9 1.3 2.9 -1.2 -0.9 -1.3 -3.0 -0.8
Birth weight of first child 0.8 1.4 2.9 -1.2 1.2 -1.7 -1.1 -0.7 -0.9 -1.3
Peak expiratory flow (PEF) 0.1 0.3 0.9 -0.3 -0.7 -0.6 -1.0 0.2 0.2 -0.5
Pulse wave reflection index 0.7 0.8 1.8 0.2 1.2 -0.7 -0.4 -1.1 -1.3 -0.8
Ever highly irritable/argumentative for 2 days 2.2 2.7 6.0 0.3 1.5 -1.5 -1.9 -1.5 -2.4 -1.6
Loud music exposure frequency 4.5 4.9 7.6 -0.9 2.3 -2.3 -2.4 -2.0 -2.8 -2.3
Qualifications: O levels/GCSEs or equivalent 1.3 2.0 3.2 -1.0 0.7 -1.7 -1.4 -1.8 -1.4 -1.5
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 0.9 -0.3 -0.6 0.6 0.8 0.2 0.9 0.7
Blood clot in the leg (DVT) 0.2 0.3 0.9 0.3 -0.2 0.6 -0.2 -1.0 -0.6 -0.1
Medication: Paracetamol 0.1 0.1 0.5 -0.7 0.3 -0.3 -0.0 -0.4 0.1 -0.2
Headache pain in last month 0.2 0.3 0.7 0.1 0.5 -0.6 -0.4 -0.5 -0.6 -0.8
Medication for cholesterol, blood pressure or diabetes 1.3 2.1 5.1 -0.2 -1.9 0.4 0.7 2.2 2.3 0.9
Glaucoma (self-reported) 0.6 0.7 2.5 -0.3 0.9 -0.6 -0.3 -1.6 -0.8 -0.7
Gout (self-reported) 1.1 1.5 5.2 -2.3 -1.3 -0.8 -0.8 0.4 1.2 -0.6
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 1.0 -0.5 0.9 -1.0 -0.2 -0.5 -0.6 -0.6
Medication: Amlodipine 2.0 2.9 4.0 -1.3 1.4 -1.8 -1.8 -1.8 -1.6 -2.0
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.5 0.7 0.0 0.2 0.0 0.1 -0.5 0.1
Birth weight 0.3 0.7 1.9 1.4 -0.3 0.5 0.8 1.1 0.3 0.8
Chronic bronchitis/emphysema (mother) 0.3 0.3 1.1 1.1 0.1 0.2 0.7 0.3 0.0 0.6
High blood pressure (siblings) 1.1 1.6 3.2 -0.8 0.6 -1.8 -1.6 -0.8 -1.1 -1.7
Forced vital capacity (FVC), Best measure 0.2 0.8 1.6 -0.8 -1.2 -0.5 -0.2 1.3 1.3 -0.1
Body fat percentage 0.9 3.6 10.6 -3.3 -0.3 -1.5 -2.0 -2.1 -0.3 -2.0
Leg fat percentage (right) 0.7 2.7 7.1 -2.7 -0.1 -1.3 -1.8 -1.8 -0.5 -1.7
Arm fat-free mass (right) 0.5 2.6 8.4 0.2 -2.9 1.8 0.2 1.5 1.7 1.1
Exposure to tobacco smoke outside home 0.4 0.6 1.7 -0.9 -1.3 -0.4 -0.5 0.5 1.0 -0.3
Comparative body size at age 10 0.3 0.9 2.2 0.1 0.8 -0.8 -0.9 -1.0 -1.5 -1.0
Number of full brothers 0.1 0.2 0.4 -0.4 0.6 -0.4 0.1 -0.6 -0.3 0.0
Worry too long after embarrassment 2.3 3.9 6.6 -0.6 2.5 -1.7 -1.4 -2.6 -2.3 -2.0
Seen a psychiatrist for nerves, anxiety, tension or depression 2.4 3.1 4.5 -2.1 1.2 -2.0 -1.6 -2.1 -1.2 -1.9
Wheeze or whistling in the chest in last year 2.8 5.0 10.4 -2.0 2.2 -2.1 -1.5 -3.2 -2.0 -2.1
Number of children fathered 0.6 0.7 2.3 -0.6 -1.5 0.6 -0.0 0.7 1.2 0.2
Reason for reducing amount of alcohol drunk: Health precaution 1.1 1.3 3.1 -1.8 -1.7 -0.8 -1.0 0.5 0.9 -0.8
Age at first live birth 0.4 0.7 2.5 -0.9 -1.6 -0.2 -0.7 0.3 0.9 -0.4
Pulse wave peak to peak time 0.2 0.2 0.4 -0.1 0.4 -0.7 -0.5 0.6 -0.5 -0.3
Health satisfaction 2.1 2.7 6.2 -0.6 2.5 -1.2 -0.7 -2.4 -2.0 -1.0
Shortness of breath walking on level ground 0.5 0.6 1.8 -1.4 0.1 -0.6 -0.7 -1.1 -0.2 -0.7
Qualifications: College or University degree 0.1 0.4 1.0 1.0 0.8 -0.4 0.0 0.3 -0.9 0.2
Eye problems/disorders: None of the above 0.3 0.3 0.7 -0.1 -0.0 -0.6 -0.7 -0.8 -0.6 -0.6
Mouth/teeth dental problems: Loose teeth 0.4 0.5 1.1 0.4 0.3 0.3 1.0 0.8 0.7 0.9
Emphysema/chronic bronchitis 0.0 0.1 0.2 -0.2 0.1 0.0 -0.1 -0.4 -0.3 -0.3
Medication for pain relief, constipation, heartburn 0.8 1.4 3.4 -1.8 -1.4 -1.1 -1.2 0.6 0.9 -0.8
Neck or shoulder pain in last month 0.0 0.0 0.1 -0.3 -0.1 0.1 -0.2 0.1 0.1 0.1
Medication: Blood pressure 0.9 1.6 2.9 -1.2 1.2 -1.1 -1.0 -1.7 -1.4 -1.1
Angina (self-reported) 0.7 0.9 1.8 1.2 1.3 0.7 0.5 -0.9 -1.2 0.2
Migraine (self-reported) 0.2 0.3 0.6 -0.0 -0.0 -0.6 -0.7 -0.5 -0.6 -0.8
Medication: Ibuprofen 0.3 0.3 0.7 0.8 0.8 -0.1 0.1 -0.4 -0.8 -0.0
Medication: Allopurinol 1.2 1.6 4.0 -0.7 -2.0 0.8 0.3 1.4 1.9 0.7
Medication: Omeprazole 0.1 0.1 0.6 -0.3 0.4 -0.0 0.3 -0.8 -0.2 -0.0
Medication: Seretide 50 evohaler 1.0 1.1 1.8 -0.6 0.6 -1.0 -1.2 -1.3 -1.1 -1.2
Mean time to correctly identify matches 0.8 1.5 2.7 0.0 -1.3 1.4 1.6 0.5 1.6 1.1
Heart disease (mother) 0.5 0.6 1.4 0.8 0.9 0.0 -0.2 -1.0 -1.2 -0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.3 0.8 0.2 0.5 -0.9 0.0 0.8 0.0 -0.2
Whole body fat mass 0.7 2.8 8.7 -3.0 -0.9 -1.1 -1.9 -1.5 0.1 -1.6
Leg fat mass (right) 0.7 2.7 7.4 -2.7 -0.9 -1.1 -2.2 -1.4 -0.1 -1.7
Arm predicted mass (right) 0.5 2.3 7.8 0.0 -2.8 1.6 0.0 1.4 1.7 1.0
Pulse rate, automated reading 1.3 4.3 9.4 0.5 -2.4 1.6 1.3 3.1 2.6 2.0
Alcohol intake frequency. 0.5 1.1 1.8 -1.3 -0.4 -0.6 -1.4 -1.2 -0.4 -1.3
Comparative height size at age 10 0.2 1.3 4.4 -0.3 -2.1 0.6 0.0 1.2 1.7 0.2
Number of full sisters 1.1 1.4 2.4 -1.3 -0.0 -1.6 -1.5 -0.8 -0.5 -1.5
Suffer from ‘nerves’ 3.5 5.5 8.7 -2.4 0.8 -2.5 -2.8 -2.5 -1.8 -3.0
Overall health rating 0.7 1.4 3.1 -1.2 0.5 -0.9 -1.2 -1.8 -0.9 -1.4
Chest pain or discomfort 0.8 1.2 2.3 -0.3 1.5 -0.7 -0.5 -1.5 -1.5 -0.9
Had major operations 0.2 0.2 0.7 0.8 0.4 0.4 0.2 0.2 -0.5 0.5
Age at last live birth 0.8 1.1 3.6 -1.0 -1.9 0.2 -0.0 0.6 1.7 -0.1
Family relationship satisfaction 0.2 0.3 1.2 0.3 1.1 -0.3 0.5 0.0 -0.4 0.2
Leg pain on walking 0.2 0.2 0.5 -0.7 -0.7 0.2 -0.3 0.2 0.5 -0.3
Qualifications: NVQ or HND or HNC or equivalent 1.2 1.4 3.6 -1.9 -0.2 -1.6 -1.1 -0.6 0.4 -1.5
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.3 -0.1 -0.1 -0.2 -0.5 -0.6 -0.5 -0.2
Illness, injury, bereavement, stress in last 2 years 1.1 1.3 2.7 1.3 -0.5 0.6 1.6 1.5 0.9 1.1
Medication: Aspirin 1.1 1.4 4.4 1.0 1.5 -0.6 -0.7 -1.0 -2.1 -0.7
Supplements: Vitamin C 0.8 1.0 2.2 -0.9 0.1 -1.1 -1.5 -0.9 -0.9 -1.2
Knee pain experienced in last month 0.5 0.8 2.7 -0.7 -1.7 0.4 -0.6 0.7 1.3 -0.1
Hypertension (Self-reported) 2.5 7.1 10.8 -1.7 2.5 -2.5 -2.5 -3.3 -3.0 -2.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.4 1.7 4.8 0.7 1.7 -0.4 -0.3 -1.7 -2.2 -0.4
Illnesses of father: Heart disease 1.5 2.1 5.1 0.4 1.5 -1.2 -1.5 -1.2 -2.3 -1.4
Illnesses of siblings: Diabetes 0.0 0.0 0.0 -0.2 0.1 -0.0 -0.1 0.2 0.1 0.0
Smoking status: Previous 0.0 0.0 0.1 0.2 -0.2 0.3 0.1 0.1 -0.1 0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.1 0.4 -0.3 -0.6 -0.2 -0.4 -0.3 -0.1 -0.5
Whole body fat-free mass 0.3 1.6 6.7 -0.6 -2.6 0.9 -0.6 1.0 1.4 0.3
Leg fat-free mass (right) 0.2 1.1 3.1 -1.2 -1.8 -0.1 -1.5 -0.2 0.4 -0.8
Arm fat percentage (left) 1.2 4.9 7.2 -2.7 0.9 -2.1 -2.5 -2.7 -1.6 -2.4
Average weekly red wine intake 2.2 3.3 5.7 -2.2 0.9 -2.4 -2.0 -1.8 -0.9 -2.0
Handedness (chirality/laterality): Left-handed 0.0 0.1 0.1 -0.1 -0.1 -0.3 -0.2 -0.3 -0.2 -0.3
Mood swings 1.5 2.7 5.4 -2.3 -0.6 -1.5 -2.1 -1.5 -0.0 -2.1
Loneliness, isolation 4.0 5.6 10.6 -3.3 0.7 -2.5 -2.7 -2.3 -0.9 -2.9
Long-standing illness, disability or infirmity 0.2 0.2 0.7 0.4 0.2 0.7 0.0 -0.5 -0.9 -0.1
Ever had bowel cancer screening 0.5 0.6 0.8 0.4 -0.9 0.9 0.7 0.9 0.8 0.5
Diabetes diagnosed by doctor 0.1 0.2 0.7 0.2 0.8 0.0 0.4 -0.2 -0.5 0.3
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.8 2.3 1.5 0.8 0.6 0.9 0.5 -0.4 1.0
Friendships satisfaction 0.3 0.4 1.0 0.6 1.0 -0.8 -0.2 0.1 -1.0 -0.4
Qualifications: nursing, teaching 0.2 0.3 1.3 0.4 0.6 -1.2 -0.3 0.3 -0.5 -0.3
Commuting to job workplace: Walk 0.4 0.4 0.9 -0.6 0.1 -0.7 -0.9 -0.2 -0.4 -0.9
Eye problems/disorders: Cataract 0.1 0.1 0.2 -0.5 0.3 -0.3 -0.4 0.0 -0.2 -0.5
Mouth/teeth dental problems: Mouth ulcers 0.4 0.7 3.2 1.8 0.3 0.7 -0.2 0.2 -1.1 0.1
Medication for cholesterol 1.6 2.4 5.8 0.2 -1.8 1.0 1.3 1.8 2.4 1.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.9 3.5 5.3 -0.8 1.8 -1.7 -1.7 -2.3 -2.2 -2.1
Back pain experienced in last month 0.7 1.0 2.2 1.5 -0.2 1.2 1.0 1.0 0.3 0.9
Mineral and other dietary supplements 0.5 0.7 1.6 0.7 1.3 -0.1 0.2 -1.1 -1.2 -0.0
Breast cancer (self-reported) 1.0 1.2 3.8 -1.9 -0.8 -1.3 -0.6 -0.0 0.9 -1.0
Asthma (self-reported) 2.2 4.3 7.6 -2.8 1.0 -2.3 -1.7 -2.7 -1.1 -2.4
Osteoporosis (self-reported) 0.3 0.4 1.1 0.8 1.0 -0.2 0.4 0.8 -0.3 0.3
Osteoarthritis (self-reported) 0.2 0.2 0.4 -0.5 -0.6 0.5 0.1 0.3 0.7 0.2
Medication: Aspirin 1.4 1.8 5.1 0.6 1.8 -0.9 -0.8 -1.3 -2.2 -1.0
Medication: Gliclazide 0.6 0.6 2.4 1.6 0.2 0.4 0.3 1.0 -0.6 0.6
Illnesses of father: None of the above (group 1) 3.7 4.6 6.2 0.9 -1.6 2.1 2.5 2.5 2.5 2.5
Smoking status: Current 0.3 0.4 1.2 0.4 -0.0 0.4 0.6 1.1 0.8 0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.2 0.8 -0.6 0.2 -0.9 -0.3 0.6 0.1 -0.1
Whole body water mass 0.3 1.6 6.7 -0.4 -2.6 1.1 -0.5 1.0 1.4 0.4
Leg predicted mass (right) 0.2 1.1 3.2 -1.3 -1.8 -0.1 -1.4 -0.2 0.5 -0.8
Arm fat mass (left) 0.7 2.8 6.1 -2.5 -0.4 -1.4 -2.2 -1.7 -0.7 -1.9
Number of self-reported non-cancer illnesses 1.0 1.8 3.3 -0.4 1.6 -1.0 -0.9 -1.6 -1.8 -1.4
Average weekly champagne plus white wine intake 0.1 0.2 0.4 0.5 0.1 0.4 0.6 -0.1 -0.0 0.5
Miserableness 0.5 0.9 1.6 -1.3 -0.8 -0.5 -1.2 -0.5 0.5 -1.2
Guilty feelings 1.3 1.9 4.1 -0.1 1.6 -1.5 -1.0 -1.5 -2.0 -1.1
Wears glasses or contact lenses 0.5 0.6 1.3 0.7 1.1 0.4 -0.2 -0.9 -1.1 -0.3
Ever taken oral contraceptive pill 0.8 0.8 1.9 -1.0 -0.3 -0.9 -1.4 -0.7 -0.4 -1.2
Hearing aid user 0.9 1.0 2.0 -0.5 0.6 -1.4 -1.4 -0.4 -1.0 -1.2
Mother’s age at death 3.5 4.4 8.6 -0.1 -2.9 1.7 1.3 2.7 2.9 1.5
Financial situation satisfaction 0.7 0.8 2.0 -0.1 1.4 -0.6 -0.2 -1.1 -1.3 -0.7
Tinnitus: Yes, now most or all of the time 0.7 0.8 1.1 0.9 -0.6 1.1 1.0 0.9 0.8 0.9
Commuting to job workplace: Public transport 1.2 1.4 2.0 -0.7 1.0 -1.3 -1.4 -1.1 -1.3 -1.4
Eye problems/disorders: Glaucoma 0.3 0.4 0.9 -0.9 0.1 -0.5 -0.5 -0.9 -0.2 -0.7
Medication: Blood pressure 1.8 3.4 6.6 -0.0 2.0 -1.2 -1.6 -2.4 -2.6 -1.8
Pain type(s) experienced in last month: Hip pain 0.2 0.3 0.6 0.3 0.1 -0.4 -0.8 -0.1 -0.7 -0.7
Supplements: Fish oil (including cod liver oil) 0.0 0.0 0.1 -0.2 0.1 -0.0 -0.3 -0.1 -0.1 -0.3
High cholesterol (Self-reported) 1.3 2.3 6.8 0.8 2.6 -0.6 -0.4 -1.3 -2.5 -0.5
Medication: Bendroflumethiazide 1.7 2.6 4.9 -0.4 2.2 -1.9 -1.4 -1.4 -2.0 -1.3
Medication: Paracetamol 0.4 0.7 1.1 -0.6 1.1 -1.0 -0.5 -1.0 -0.7 -0.8
Medication: Lisinopril 0.8 1.0 2.7 -0.1 1.6 -0.4 -0.2 -1.4 -1.5 -0.5
Medication: Atorvastatin 0.4 0.4 1.8 0.3 1.4 -0.1 0.4 -0.1 -0.9 0.3
Illnesses of father: High blood pressure 7.4 9.1 13.3 -2.7 1.8 -3.0 -3.4 -3.6 -2.4 -3.6
Alcohol drinker status: Never 2.1 2.5 5.4 -0.2 1.6 -0.9 -1.3 -2.3 -2.2 -1.4
Ever smoked 0.3 0.5 1.4 -0.1 -0.5 0.7 0.4 1.2 1.0 0.5
Basal metabolic rate 0.3 1.6 6.3 -1.2 -2.5 0.5 -1.0 0.5 1.3 -0.2
Leg fat percentage (left) 0.6 2.3 7.2 -2.7 -0.8 -1.0 -1.7 -1.5 0.1 -1.5
Arm fat-free mass (left) 0.5 2.6 9.4 -0.7 -3.1 1.4 -0.1 1.3 2.1 0.7
Number of operations (self-reported) 0.2 0.3 1.0 0.4 -0.3 0.5 0.4 1.0 0.3 0.3
Average weekly beer plus cider intake 0.9 1.2 3.2 -0.3 -1.8 1.0 0.4 1.2 1.6 0.6
Irritability 0.1 0.2 0.5 -0.4 -0.6 -0.3 -0.6 -0.2 0.2 -0.7
Risk taking 0.3 0.4 1.1 0.2 0.9 -0.3 -0.1 -1.1 -0.8 -0.2
Ever had prostate specific antigen (PSA) test 1.4 1.6 3.1 -0.3 1.8 -1.1 -1.0 -1.6 -1.6 -0.8
Fractured/broken bones in last 5 years 0.4 0.5 2.0 1.4 0.4 0.6 0.2 -0.2 -0.9 0.2
Age started oral contraceptive pill 1.2 1.5 3.8 0.2 -1.6 0.5 0.8 1.9 1.7 0.8
Diastolic blood pressure, automated reading 1.4 4.2 6.2 -1.9 0.9 -2.3 -2.2 -2.5 -1.7 -2.4
Ever depressed for a whole week 2.5 3.1 7.6 0.5 2.8 -1.1 -0.7 -2.0 -2.6 -1.2
Unable to work because of sickness or disability 1.9 2.4 5.4 1.5 -0.2 2.2 2.3 0.7 0.9 1.8
Commuting to job workplace: Cycle 1.0 1.2 3.3 0.9 -1.3 0.5 0.8 1.8 1.2 0.5
Myopia 3.3 4.8 10.1 -0.8 2.4 -1.9 -1.5 -3.2 -2.7 -1.9
Vascular/heart problems diagnosed by doctor 2.1 5.7 10.2 0.8 -2.4 1.7 2.1 3.2 3.2 2.5
Cholesterol lowering medication 1.3 2.0 5.0 0.4 2.2 -1.1 -0.9 -0.9 -2.2 -0.9
Medication: Omeprazole (e.g. Zanprol) 0.4 0.4 1.7 -0.6 0.7 -0.3 -0.0 -1.3 -0.5 -0.3
Pain experienced in last month 0.2 0.4 0.9 0.8 -0.0 0.4 1.0 0.3 0.1 0.9
Supplements: Calcium 0.6 0.6 1.8 -0.6 -0.7 -0.1 0.5 1.1 1.3 0.2
Basal cell carcinoma (self-reported) 0.2 0.2 1.1 -1.0 -0.1 -0.3 -0.2 -0.4 0.3 -0.3
Heart attack/myocardial infarction (self-reported) 0.3 0.4 1.5 -1.2 -0.2 -0.5 -0.8 -0.3 0.1 -0.5
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 1.3 0.4 0.1 0.6 -0.2 -1.2 -0.9 -0.1
Heart disease (siblings) 0.1 0.1 0.5 -0.1 0.3 -0.7 -0.2 0.2 -0.2 -0.2
Alcohol drinker status: Previous 1.8 2.0 6.3 -2.5 -0.7 -1.3 -1.4 -0.9 0.2 -1.6
Pack years of smoking 2.6 3.8 6.9 1.2 -1.2 1.8 2.2 2.6 2.0 2.1
Impedance of whole body 0.5 2.7 9.8 -3.1 -1.0 -1.6 -0.7 -0.1 1.6 -1.5
Leg fat mass (left) 0.6 2.4 7.0 -2.6 -1.2 -0.9 -2.0 -1.3 0.2 -1.5
Arm predicted mass (left) 0.5 2.6 9.0 -0.4 -3.0 1.5 -0.1 1.4 2.0 0.8