TWAS hub - LETMD1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1080	0.0380	4.7e-05	0.043	0.033	0.015	0.033	0.025	4.7e-06	6.0e-05	5.3e-03	5.9e-05	4.4e-04
2	GTEx	Adipose Subcutaneous	0.0590	0.0260	3.8e-03	0.005	NA	0.003	NA	0.003	1.1e-01	NA	1.7e-01	NA	1.9e-01
3	GTEx	Lung	0.0781	0.0296	5.9e-04	0.073	NA	0.062	NA	0.083	2.8e-06	NA	1.7e-05	NA	6.8e-07
4	GTEx	Muscle Skeletal	0.0996	0.0333	4.2e-06	0.065	NA	0.074	NA	0.008	5.4e-07	NA	9.4e-08	NA	4.6e-02
5	NTR	Blood	0.0235	0.0087	6.0e-05	0.016	0.012	0.007	0.012	0.012	4.1e-06	8.3e-05	2.4e-03	5.9e-05	8.1e-05
6	YFS	Blood	0.0505	0.0145	1.9e-09	0.039	0.037	0.052	0.045	0.053	9.2e-13	4.3e-12	1.6e-16	2.1e-14	9.9e-17
7	TCGA	Breast Invasive Carcinoma	0.0158	0.0094	1.8e-03	0.008	0.009	0.006	NA	0.009	6.6e-03	4.4e-03	1.5e-02	NA	5.2e-03
8	TCGA	Head and Neck Squamous Cell Carcinoma	0.0477	0.0254	4.8e-05	0.038	0.039	0.045	NA	0.044	3.9e-05	2.8e-05	8.2e-06	NA	8.8e-06
9	TCGA	Kidney Renal Clear Cell Carcinoma	0.0327	0.0186	5.9e-03	0.003	0.018	0.005	NA	0.008	1.5e-01	3.8e-03	8.0e-02	NA	4.2e-02
10	TCGA	Lung Squamous Cell Carcinoma	0.0284	0.0174	2.8e-03	0.022	0.016	0.014	NA	0.021	1.2e-03	5.2e-03	7.9e-03	NA	1.9e-03
11	TCGA	Prostate Adenocarcinoma	0.0305	0.0198	4.7e-03	0.026	0.016	0.009	NA	0.014	8.1e-04	7.4e-03	3.6e-02	NA	1.3e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Severe depression (siblings)	5.8	6.5	15.0	0.9	1.9	3.0	-3.4	1.4	1.9	-1.9	-2.6	-2.9	-2.6	-3.9
Ever unenthusiastic/disinterested for a whole week	5.2	6.4	10.4	1.2	2.4	3.1	-3.2	2.8	2.2	-2.2	-2.6	-1.6	-2.7	-3.0
High blood pressure (mother)	4.7	6.6	11.3	1.7	2.6	3.4	-3.2	2.7	3.0	-1.6	-2.5	-1.2	-2.4	-2.9
Illnesses of father: High blood pressure	4.6	5.7	14.6	3.8	1.7	2.7	-2.2	2.6	2.7	-2.2	-2.3	1.7	-1.9	-1.3
Ever depressed for a whole week	4.4	5.5	8.2	0.9	2.8	2.9	-2.8	2.2	1.9	-2.1	-2.3	-1.4	-2.7	-2.8
HbA1C	4.0	4.5	9.2	-0.2	1.3	2.1	-2.8	-0.2	0.7	-2.0	-2.5	-2.9	-2.7	-3.0
Loud music exposure frequency	4.0	4.4	9.6	1.5	1.6	2.1	-2.3	0.3	1.3	-2.7	-2.7	-0.2	-3.1	-2.7
Worry too long after embarrassment	3.5	5.9	12.4	1.9	2.5	3.4	-2.8	3.2	3.5	-1.6	-2.0	-0.2	-1.7	-1.9
Blood White Count	3.4	25.1	53.7	-1.3	0.9	3.3	-5.7	-3.1	-0.8	-6.5	-6.7	-5.9	-7.3	-6.7
Mother’s age at death	3.4	4.3	7.6	-0.8	-1.6	-2.4	2.8	-1.2	-1.4	2.4	2.6	1.5	2.4	2.6
Health satisfaction	3.3	4.3	9.3	1.0	3.1	2.3	-2.6	1.9	1.5	-2.0	-2.3	-1.2	-1.9	-2.1
Exposure to tobacco smoke at home	3.0	3.3	7.6	-0.5	-1.6	-2.6	2.3	-2.8	-2.6	1.2	1.7	0.3	1.1	1.5
Myopia	3.0	4.4	7.0	2.0	1.8	2.6	-2.5	1.6	1.9	-2.1	-2.5	-0.8	-2.2	-2.2
Medication: Simvastatin	2.8	4.2	8.6	0.1	2.4	2.9	-2.5	2.0	2.6	-1.2	-1.6	-1.3	-1.8	-2.4
Medication: Lansoprazole	2.8	3.2	7.8	1.8	-0.1	1.2	-1.9	-0.5	-0.0	-2.8	-2.6	-0.3	-2.8	-2.1
Serious illness, injury or assault to yourself	2.7	3.3	9.8	1.8	2.1	2.5	-1.4	2.6	3.1	-0.5	-1.0	1.3	-0.6	-1.2
Townsend deprivation index at recruitment	2.6	3.7	9.5	0.2	-1.2	-1.8	2.5	-0.6	-0.8	1.6	2.1	2.5	2.4	3.1
Schizophrenia vs Biploar Disorder	2.5	3.3	4.9	-2.1	-1.6	-2.0	2.0	-1.1	-1.9	1.9	1.9	-0.6	2.0	2.2
Bipolar Disorder (2011)	2.5	2.4	7.5	2.7	-0.7	0.6	-1.2	-0.1	-0.3	-2.3	-1.9	0.0	-2.4	-1.4
Cardiovascular Disease	2.5	8.3	14.9	3.9	1.8	3.7	-3.3	3.5	3.2	-2.3	-2.8	-0.4	-2.3	-2.7
Medication: Bendroflumethiazide	2.5	3.7	8.9	3.0	0.4	1.6	-2.1	0.2	0.4	-2.5	-2.5	-0.7	-2.5	-2.4
Alcohol drinker status: Never	2.5	3.0	8.1	1.0	1.8	2.6	-1.9	2.2	2.8	-0.6	-1.4	0.3	-0.9	-1.4
Pulse wave reflection index	2.4	3.0	14.0	1.9	2.1	1.7	-1.4	3.7	1.7	-0.8	-0.9	-0.0	-0.9	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.3	2.8	4.8	0.4	2.2	2.1	-1.9	1.8	1.5	-1.6	-1.9	-0.4	-1.5	-1.8
Illnesses of father: None of the above (group 1)	2.3	2.9	3.9	-1.8	-1.5	-2.0	1.8	-1.5	-2.0	1.9	1.9	-0.9	1.6	1.4
Medication: Blood pressure	2.3	4.4	12.8	3.6	0.7	2.5	-2.2	2.2	2.0	-1.7	-1.8	-0.2	-2.0	-2.3
High blood pressure	2.2	6.1	15.7	4.0	0.4	3.0	-2.7	2.3	2.6	-2.4	-2.5	-0.0	-2.3	-2.5
Hair/balding pattern: Pattern 4	2.2	5.4	12.9	0.3	2.1	2.6	-3.0	0.1	1.4	-2.2	-2.8	-1.9	-2.8	-3.6
Medication: Allopurinol	2.2	2.9	6.7	-0.7	-2.6	-1.8	2.2	-1.4	-1.1	1.4	1.8	1.4	1.7	1.8
Hypertension (Self-reported)	2.2	6.0	18.6	4.3	0.1	2.8	-2.6	2.0	2.2	-2.7	-2.6	0.2	-2.4	-2.2
Vascular/heart problems diagnosed by doctor	2.2	6.1	13.8	-3.7	-1.1	-3.3	2.6	-2.9	-3.1	1.8	2.1	-0.1	1.9	2.3
Age at First Birth	2.1	3.0	4.8	-0.6	-2.2	-1.6	2.1	-1.1	-0.5	1.8	2.2	1.8	2.0	2.0
Other serious medical condition/disability diagnosed by doctor	2.1	2.7	9.5	-0.1	2.1	2.5	-1.5	2.1	3.1	0.3	-0.4	-0.4	-0.2	-1.6
Cholesterol lowering medication	2.1	3.0	6.3	1.0	1.1	1.9	-2.1	1.2	0.9	-1.9	-2.1	-0.9	-2.4	-2.5
Crohns Disease (2017)	2.0	4.4	8.0	-2.1	-1.6	-2.7	2.6	-2.8	-2.7	1.3	1.8	0.8	1.5	2.1
Number of treatments/medications taken	2.0	3.6	7.0	1.4	0.8	2.6	-2.5	1.3	2.3	-1.6	-1.8	-1.2	-1.9	-2.4
Hearing difficulty/problems: Yes	2.0	3.0	7.9	2.8	1.5	1.6	-1.7	2.0	0.7	-2.0	-1.9	-0.2	-1.9	-1.4
Taking other prescription medications	2.0	3.1	8.4	0.7	1.6	2.7	-2.1	2.1	2.9	-0.5	-1.1	-1.2	-0.7	-1.7
Prospective memory result	2.0	2.4	6.7	-0.5	-1.2	-0.5	1.4	0.4	0.6	2.5	2.1	1.3	2.6	1.7
High cholesterol (Self-reported)	2.0	3.6	8.4	-0.1	0.9	2.3	-2.5	0.5	1.4	-1.7	-2.1	-2.1	-2.3	-2.9
Blood Eosinophil Count	1.9	14.4	26.7	-0.2	4.1	3.2	-4.5	0.3	0.5	-4.2	-4.6	-4.6	-5.2	-5.0
Had other major operations	1.9	2.3	3.7	-1.8	-1.4	-1.9	1.7	-1.7	-1.9	1.5	1.7	-0.9	0.8	1.0
Neuroticism	1.8	4.3	11.5	2.8	1.3	2.5	-1.7	3.1	3.4	-1.0	-1.3	2.0	-0.8	-0.6
Medication: Cholesterol lowering	1.8	2.8	5.9	-0.7	1.9	2.4	-2.1	0.9	1.9	-1.0	-1.5	-1.7	-1.3	-1.9
Reason for reducing amount of alcohol drunk: Health precaution	1.8	2.1	5.8	1.3	-2.0	-1.6	1.5	0.1	-1.1	0.2	0.8	2.4	1.1	2.0
Pulse rate, automated reading	1.8	5.8	13.0	-1.0	-3.5	-3.1	2.8	-3.6	-2.9	1.6	2.1	0.6	1.1	1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.8	2.1	4.2	1.1	0.4	2.0	-1.9	1.7	1.7	-0.4	-1.5	-1.3	-0.8	-1.7
Medication for cholesterol	1.8	2.7	4.1	-1.8	-1.3	-1.8	1.8	-1.8	-1.2	1.7	1.7	0.5	1.9	2.0
Wears glasses or contact lenses	1.8	2.1	6.8	0.9	1.7	2.1	-1.5	2.6	2.1	0.1	-0.5	-0.3	-0.0	-1.1
Verbal and Numeric Reasoning (VNR)	1.7	4.2	8.7	-0.9	1.4	2.1	-2.7	0.5	1.0	-2.1	-2.6	-2.1	-2.5	-2.9
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.3	4.2	-0.3	-2.0	-1.8	1.9	-1.6	-1.4	1.3	1.8	0.8	1.1	1.8
Bilateral oophorectomy (both ovaries removed)	1.7	1.9	3.5	0.2	-1.5	-1.9	1.8	-0.9	-1.6	0.7	1.1	1.6	1.1	1.7
Supplements: Glucosamine	1.7	2.2	4.1	0.2	-1.2	-1.1	1.8	-0.3	0.0	1.9	1.9	2.0	1.9	1.8
Frequency of tenseness / restlessness in last 2 weeks	1.7	2.6	4.7	2.0	1.7	2.1	-1.6	2.1	2.2	-1.1	-1.4	0.7	-1.0	-1.0
Standing height	1.7	16.5	34.2	1.1	-4.7	-3.3	4.9	-0.8	-0.6	4.1	4.5	5.0	5.2	5.8
Wheeze or whistling in the chest in last year	1.7	3.1	5.8	1.4	1.3	2.0	-2.2	1.2	1.0	-2.4	-2.4	-0.8	-2.0	-1.6
Suffer from ‘nerves’	1.7	2.6	6.0	2.2	1.0	1.9	-1.3	2.5	2.4	-1.0	-1.4	1.8	-0.5	-0.4
Age started oral contraceptive pill	1.7	2.1	4.2	-1.2	-1.5	-2.0	1.8	-1.4	-2.0	0.8	1.3	0.3	1.2	1.5
Neuroticism (Nagel 2018)	1.6	3.8	12.7	2.7	1.3	2.1	-1.1	3.6	3.1	-0.6	-0.6	2.0	-0.5	0.2
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.8	4.4	0.2	1.8	1.9	-1.3	1.9	2.1	-0.3	-0.8	0.2	-0.7	-1.4
Ever highly irritable/argumentative for 2 days	1.6	2.0	4.2	1.4	1.5	1.1	-1.4	-0.1	0.5	-1.7	-1.8	-0.3	-1.9	-2.1
Angina (self-reported)	1.6	2.2	5.1	0.8	2.3	2.0	-1.6	1.6	2.2	0.3	-0.5	-1.3	-0.0	-1.4
Illnesses of father: Heart disease	1.6	2.2	3.2	1.4	1.7	1.8	-1.6	1.8	1.6	-1.3	-1.5	0.5	-1.1	-1.7
Medication: Aspirin	1.6	2.1	4.1	0.7	1.2	2.0	-1.9	1.1	1.9	-1.0	-1.4	-0.9	-1.0	-1.9
Height	1.5	29.5	56.8	1.6	-6.5	-4.9	6.7	-1.5	-1.7	5.3	6.0	6.2	6.7	7.5
Medication: Co-codamol	1.5	1.8	3.5	-0.6	-1.7	-1.0	1.4	-1.5	-0.1	1.4	1.5	1.2	1.9	1.5
Number of live births	1.5	2.1	3.6	-1.0	-1.1	-1.9	1.6	-1.1	-1.8	1.4	1.6	-0.8	1.5	1.9
Medication for cholesterol, blood pressure or diabetes	1.5	2.5	6.5	-0.9	-1.2	-2.6	2.0	-1.0	-2.4	0.9	1.4	0.7	1.1	1.6
Mouth/teeth dental problems: Loose teeth	1.5	1.8	6.3	-1.4	-1.2	-1.2	0.1	-2.5	-2.1	-0.7	-0.4	-1.7	-0.7	-0.4
Age at last live birth	1.5	2.1	4.1	-1.3	-2.0	-1.3	1.7	-0.9	-0.6	1.3	1.5	1.3	1.6	2.0
Ever had prostate specific antigen (PSA) test	1.5	1.7	3.4	0.9	0.4	1.2	-1.6	-0.6	0.5	-1.7	-1.7	-0.7	-1.8	-1.8
Depressed Affect (Nagel 2018)	1.4	3.0	8.4	2.4	1.1	1.3	0.1	2.7	2.6	0.4	0.4	2.9	0.4	1.1
Alcohol usually taken with meals	1.4	2.3	5.7	-0.8	1.5	1.2	-1.5	-0.6	0.2	-1.1	-1.7	-2.2	-2.0	-2.4
Financial situation satisfaction	1.4	1.7	3.8	-0.4	1.9	1.6	-1.5	1.8	1.2	-1.1	-1.2	-0.7	-1.1	-1.1
Coronary Artery Disease (CAD)	1.3	1.5	3.6	-0.3	0.6	1.0	-1.6	0.2	-0.0	-1.0	-1.6	-1.9	-1.4	-1.9
Chronotype (morning person)	1.3	3.0	5.9	0.6	-2.2	-1.6	2.3	-1.5	-0.6	1.7	2.0	2.4	1.4	1.5
Angina	1.3	1.8	4.2	0.5	2.1	1.8	-1.5	1.2	1.8	0.5	-0.3	-1.6	-0.0	-1.4
Sitting height	1.3	8.9	20.7	2.1	-2.8	-1.8	3.4	1.0	0.5	3.2	3.4	4.5	3.6	3.8
Fluid intelligence score	1.3	2.7	5.9	-0.5	1.4	1.1	-1.8	-0.4	0.1	-2.2	-2.3	-1.3	-2.4	-2.2
Illnesses of mother	1.3	1.6	2.8	-1.0	-0.8	-1.2	1.7	-0.7	-0.5	1.4	1.4	1.4	1.6	1.6
Medication: Amlodipine	1.3	1.8	5.5	2.3	-0.5	1.1	-1.3	0.2	0.6	-2.1	-1.8	0.4	-1.4	-1.1
Number of children fathered	1.3	1.5	3.1	-0.4	-1.7	-0.9	1.5	-0.8	-0.3	0.9	1.3	1.4	1.3	1.8
Medication: Aspirin	1.3	1.7	3.3	0.5	1.2	1.8	-1.7	0.9	1.8	-0.7	-1.1	-0.8	-0.8	-1.8
Mood swings	1.3	2.4	6.8	2.2	1.0	1.0	0.1	2.6	2.1	0.4	0.3	2.6	0.7	1.1
Loneliness, isolation	1.3	1.9	4.3	2.1	1.1	1.2	-0.7	1.7	1.4	-1.5	-1.2	1.8	-0.8	0.0
Average weekly beer plus cider intake	1.3	1.9	3.4	-0.4	-1.7	-1.8	1.8	-0.8	-1.4	1.3	1.6	0.8	1.4	1.5
Intelligence (Savage-Jansen 2018)	1.2	3.6	7.2	-0.8	1.0	1.8	-2.4	0.3	0.5	-2.1	-2.5	-2.3	-2.4	-2.7
Rheumatoid Arthritis	1.2	1.7	8.2	2.9	-0.9	-0.5	0.6	-0.0	-0.3	-1.1	-0.2	2.4	-0.6	1.1
Blood Platelet Count	1.2	13.4	23.6	-2.5	4.9	3.2	-4.1	-1.1	0.8	-4.5	-4.4	-2.5	-4.8	-4.6
Average weekly spirits intake	1.2	1.4	4.9	0.4	1.7	1.7	-0.9	1.9	2.2	0.6	0.1	0.2	0.1	-0.7
Sensitivity / hurt feelings	1.2	2.1	4.3	1.3	1.0	1.6	-1.7	2.1	1.7	-1.6	-1.6	0.2	-1.2	-0.8
Pack years adult smoking proportion	1.2	1.8	3.4	-1.0	-1.1	-1.5	1.5	-1.2	-1.2	1.8	1.7	-0.7	1.5	1.2
Hand grip strength (right)	1.2	3.2	7.6	-1.5	-2.5	-2.3	1.8	-2.8	-2.2	1.2	1.3	0.0	1.2	1.2
Hayfever, allergic rhinitis or eczema	1.2	2.6	8.6	0.3	-2.9	-1.8	1.6	-1.7	-1.6	-0.3	0.8	1.9	0.6	2.0
Neuroticism score	1.2	2.4	6.8	2.4	0.5	1.7	-0.9	2.4	2.6	-0.4	-0.5	2.0	-0.0	0.2
Breastfed as a baby	1.2	1.5	2.5	-1.2	-1.1	-1.4	1.4	-0.3	-1.1	1.6	1.5	0.0	1.6	1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.6	2.6	1.5	0.9	1.4	-1.3	1.6	1.1	-1.6	-1.5	0.3	-1.3	-0.8
Knee pain experienced in last month	1.2	1.8	2.6	1.3	-1.5	-0.9	1.6	-0.7	0.2	1.5	1.6	1.6	1.6	1.5
Diastolic blood pressure, automated reading	1.2	3.8	17.4	4.2	-0.7	1.7	-1.4	2.9	2.1	-1.2	-1.4	1.5	-0.6	-0.1
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	4.9	-0.6	-1.1	-1.2	0.5	-2.2	-2.0	-0.6	-0.1	-0.7	-0.5	-0.1
Stomach or abdominal pain in last month	1.1	1.4	2.6	0.4	-0.1	-0.0	1.2	1.0	1.1	1.4	1.5	1.6	1.5	1.5
Gout (self-reported)	1.1	1.5	4.2	0.4	-2.1	-1.3	1.4	-0.5	-1.0	0.1	0.7	1.7	0.8	1.6
Mouth/teeth dental problems: Mouth ulcers	1.1	1.8	6.1	0.4	2.5	1.6	-0.7	1.6	2.4	0.9	0.3	0.5	0.3	-1.0
Guilty feelings	1.1	1.6	3.7	0.8	0.0	1.2	-1.6	0.3	0.6	-1.9	-1.7	-0.6	-1.9	-1.6
Commuting to job workplace: Public transport	1.1	1.4	3.2	0.1	1.8	1.3	-1.1	1.1	1.2	-0.7	-1.2	-0.3	-1.2	-1.7
Medication: Lisinopril	1.1	1.4	2.4	0.5	1.0	1.5	-1.5	0.6	0.9	-1.2	-1.1	-1.2	-1.5	-1.5
Crohns Disease (2012)	1.0	1.6	5.3	-1.4	-1.2	-1.6	1.3	-2.3	-1.8	0.2	0.7	0.3	0.0	0.7
Lupus	1.0	1.5	4.0	-0.9	-2.0	-1.3	0.9	-1.3	-1.2	1.1	1.0	-0.4	1.3	1.4
Hand grip strength (left)	1.0	2.6	5.5	-1.3	-2.3	-2.2	1.7	-2.3	-2.0	1.2	1.3	0.2	0.9	0.9
Ever had hysterectomy (womb removed)	1.0	1.1	2.5	1.2	-0.7	-1.2	1.2	-0.2	-1.1	0.3	0.7	1.6	0.6	1.5
Systolic blood pressure, automated reading	1.0	2.8	10.7	3.3	-0.7	1.8	-1.7	2.2	1.9	-1.3	-1.5	0.5	-0.7	-0.6
Impedance of leg (left)	1.0	4.8	12.9	0.9	-3.6	-2.3	2.3	-1.1	-1.5	1.3	1.8	1.5	2.7	3.4
Hearing difficulty/problems with background noise	1.0	1.7	2.9	1.3	-0.3	1.4	-1.6	0.9	0.8	-1.7	-1.7	-0.5	-1.7	-1.4
Mouth/teeth dental problems: Dentures	1.0	1.6	6.6	-0.2	2.6	1.3	-0.8	1.5	1.5	1.1	0.1	-1.3	0.6	-1.1
Pulse wave Arterial Stiffness index	1.0	1.1	4.0	1.3	-0.0	0.1	0.6	2.0	0.8	1.0	1.2	0.8	1.1	1.2
Tense / ‘highly strung’	1.0	1.6	4.5	0.7	-1.4	-0.4	1.0	1.3	0.3	0.8	1.0	2.1	1.4	2.0
Medication: Seretide 50 evohaler	1.0	1.2	3.1	1.4	1.2	1.3	-0.9	1.6	1.8	-0.3	-0.7	0.8	-0.1	-0.4
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	3.4	-1.1	-1.8	-1.4	0.7	-1.3	-1.8	0.1	0.4	-0.5	0.6	1.0
Hearing aid user	1.0	1.1	2.4	1.4	1.6	0.3	-0.8	1.4	-0.2	-1.2	-1.2	0.5	-1.1	-0.8
Pack years of smoking	1.0	1.5	3.5	-0.9	-0.6	-1.2	1.4	-0.8	-0.9	1.9	1.7	-0.5	1.6	1.2
Worry (Nagel 2018)	0.9	1.9	7.8	1.7	0.6	1.4	-0.8	2.8	2.2	-0.1	-0.4	1.2	0.4	0.5
Mean Putamen Volume	0.9	1.0	3.2	1.7	0.2	0.9	-0.6	1.8	1.2	-0.7	-0.9	1.1	-0.3	-0.1
Primary Biliary Cirrhosis	0.9	1.3	4.6	1.0	0.5	0.8	-1.2	0.4	0.1	-2.1	-1.6	-0.0	-1.7	-0.8
Triglycerides	0.9	1.4	6.6	-1.9	0.1	0.4	-1.3	-0.6	-0.5	-0.5	-0.7	-2.6	-0.6	-1.4
Allergy or Eczema	0.9	2.5	8.9	-0.8	-3.0	-1.8	1.6	-2.0	-1.6	0.4	1.3	0.7	0.8	1.7
Qualifications: None of the above	0.9	1.9	4.2	0.7	2.0	0.7	0.3	1.8	1.6	2.0	1.5	0.4	1.8	0.5
Hip circumference	0.9	3.8	11.0	1.6	-2.5	-0.8	2.1	-0.1	0.7	1.5	1.8	3.3	1.9	2.7
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.4	5.9	1.4	-0.1	0.5	0.3	1.6	1.6	0.1	0.4	2.4	0.7	1.3
Pulse rate	0.9	1.5	4.0	-0.3	-1.9	-1.5	1.5	-2.0	-1.5	0.7	0.8	0.6	0.5	0.7
Age at first live birth	0.9	1.6	3.4	-0.9	-1.5	-1.0	1.4	-0.8	-0.1	0.8	1.1	1.9	1.4	1.6
Medication for pain relief, constipation, heartburn	0.9	1.6	3.6	0.3	-1.0	-1.9	1.5	-0.8	-1.9	-0.2	0.3	1.9	0.3	1.5
Average weekly red wine intake	0.9	1.3	4.4	1.5	-0.0	0.6	-0.9	0.6	0.1	-2.1	-1.7	0.8	-1.4	-0.3
Friendships satisfaction	0.9	1.1	1.8	-1.2	1.0	0.2	-1.0	0.6	-0.7	-1.4	-1.2	-0.9	-1.3	-1.2
Mineral and other dietary supplements	0.9	1.2	3.3	-0.9	1.8	1.0	-1.3	0.6	0.4	-0.9	-1.2	-1.5	-1.0	-1.1
Number of self-reported non-cancer illnesses	0.9	1.6	3.6	1.2	0.6	1.9	-1.6	0.6	1.6	-1.1	-1.4	-0.7	-1.1	-1.4
Miserableness	0.9	1.5	4.4	1.3	0.5	0.7	0.4	1.7	1.9	1.0	0.9	2.1	0.7	1.1
Arm fat-free mass (left)	0.9	4.7	9.9	-0.2	-1.0	-1.4	2.8	-0.4	0.4	3.1	2.9	2.8	2.7	2.7
Arm predicted mass (left)	0.9	4.5	9.6	-0.2	-1.2	-1.4	2.7	-0.4	0.3	3.1	2.9	2.6	2.7	2.6
Alzheimer’s Disease (including proxy)	0.8	1.2	3.5	1.4	-0.3	-0.7	0.0	-1.1	-1.4	-1.9	-1.0	0.7	-1.3	0.3
Irritable Bowel Disease (IBD)	0.8	2.0	5.5	-2.3	-0.6	-1.6	1.6	-1.9	-1.9	1.2	1.2	-0.2	0.9	0.6
LDL Cholesterol	0.8	1.3	4.2	0.1	2.0	1.5	-1.2	1.1	1.4	-0.1	-0.6	-0.9	-0.4	-1.2
Neuroticism (2016)	0.8	1.2	3.4	1.8	-0.1	0.8	-0.2	1.7	1.6	-0.1	0.1	1.8	0.2	0.5
Heel T-Score	0.8	6.2	20.1	2.3	-1.3	-2.7	3.0	0.7	-2.0	0.2	1.4	3.9	1.8	4.5
Systolic Blood Pressure	0.8	3.9	14.4	3.8	-1.9	2.0	-2.2	1.5	1.6	-1.7	-2.1	-0.4	-1.2	-1.4
Medication for hormone replacement therapy	0.8	0.9	4.3	0.7	1.7	0.6	-0.3	2.1	0.9	-0.4	-0.5	1.0	-0.1	-0.1
Average weekly fortified wine intake	0.8	1.0	1.9	-0.8	1.4	1.2	-1.0	0.7	1.2	-0.1	-0.3	-1.2	-0.6	-1.3
Medication: Levothyroxine sodium	0.8	1.3	4.0	0.9	-1.0	0.1	-0.9	-1.3	-0.5	-2.0	-1.6	-0.6	-1.4	-1.0
Financial difficulties in last 2 years	0.8	1.1	3.6	1.6	1.2	0.8	0.1	1.9	1.3	-0.2	0.2	1.4	-0.3	0.3
Trunk fat-free mass	0.8	4.4	10.9	-0.6	-0.9	-1.1	2.5	0.0	0.7	3.3	2.8	2.6	2.9	2.4
Trunk predicted mass	0.8	4.3	10.5	-0.5	-0.9	-1.1	2.5	0.0	0.7	3.2	2.8	2.6	2.8	2.4
Arm fat-free mass (right)	0.8	4.3	10.8	-0.5	-0.9	-1.3	2.6	-0.5	0.4	3.3	2.9	2.3	2.7	2.3
Exposure to tobacco smoke outside home	0.8	1.0	2.5	0.7	-0.6	-1.3	1.4	-0.4	-1.1	0.3	0.8	1.6	0.5	1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	3.2	-0.3	0.8	-0.8	0.0	-0.5	-1.6	-1.5	-0.7	-0.5	-1.8	-0.5
Arm predicted mass (right)	0.8	3.9	9.5	-0.3	-0.9	-1.3	2.5	-0.5	0.4	3.1	2.8	2.4	2.5	2.2
Chest pain or discomfort	0.8	1.2	2.9	0.4	0.9	1.7	-1.6	1.0	1.5	-0.7	-1.3	-0.5	-0.2	-0.9
Family relationship satisfaction	0.8	0.9	1.7	-1.1	-0.4	0.3	-0.9	-0.4	-0.8	-1.2	-1.1	-1.3	-1.2	-1.2
Diabetes diagnosed by doctor	0.8	1.2	4.7	-1.0	-1.7	0.1	-0.5	-2.2	-0.7	-1.0	-0.6	-1.1	-1.0	-0.9
Qualifications: nursing, teaching	0.8	1.2	2.7	-0.9	-0.7	-0.6	-0.3	-1.5	-1.6	-1.7	-1.2	-0.6	-1.4	-0.6
Commuting to job workplace: Cycle	0.8	0.9	1.8	-0.4	-0.7	-1.4	1.3	-0.7	-1.1	0.9	1.1	0.3	1.0	1.0
Waist Hip Ratio (WHR)	0.7	3.0	10.1	-0.9	2.4	1.6	-2.0	0.9	0.7	-0.1	-1.2	-3.2	-0.9	-2.3
Type 2 Diabetes (T2D) (2018)	0.7	1.3	3.6	-1.8	-1.3	0.0	-0.5	-1.9	-0.7	-0.4	-0.1	-1.8	-0.8	-0.8
Supplements: Zinc	0.7	0.8	2.7	-1.2	-1.1	-1.0	0.5	-1.6	-1.1	0.1	-0.1	-0.8	0.0	-0.3
Medication: Metformin	0.7	1.0	4.6	-0.7	-1.4	-0.0	-0.5	-2.1	-0.7	-0.9	-0.6	-0.8	-1.0	-0.8
Nervous feelings	0.7	1.3	4.6	1.5	0.7	1.0	-0.7	2.1	1.5	-0.6	-0.6	1.4	-0.2	-0.1
Mouth/teeth dental problems	0.7	1.1	4.7	0.4	-2.2	-0.8	0.3	-1.3	-1.3	-1.3	-0.5	0.6	-0.9	0.5
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	3.4	0.4	-1.1	-0.1	-0.6	-0.5	-0.8	-1.8	-1.5	0.2	-1.2	-0.3
Father’s age at death	0.7	1.0	2.6	0.0	-0.1	-1.6	1.3	-0.4	-1.4	0.2	0.5	1.4	0.4	1.2
Asthma	0.7	1.5	4.9	1.3	-0.1	1.2	-1.3	0.6	0.9	-2.2	-1.7	0.5	-1.4	-0.3
High blood pressure (siblings)	0.7	1.0	3.7	1.9	-0.8	0.0	-0.5	-0.1	-0.4	-1.7	-1.1	1.1	-1.1	-0.3
Pulse wave peak to peak time	0.7	0.8	4.1	-1.1	-0.2	-0.3	-0.3	-2.0	-0.8	-0.8	-0.9	-0.5	-0.7	-0.8
Mean time to correctly identify matches	0.7	1.4	3.5	-1.0	-0.1	-0.6	1.1	0.3	0.1	1.9	1.7	-0.1	1.9	1.7
Heart disease (mother)	0.7	0.9	1.7	1.0	1.2	1.3	-1.0	1.0	1.3	-0.2	-0.3	-0.2	-0.5	-1.1
Leg pain on walking	0.7	0.9	1.6	0.1	0.8	0.3	0.5	1.1	1.2	1.0	1.0	1.2	1.1	1.0
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	3.3	1.8	-0.6	-0.7	0.4	-0.7	-0.7	-1.1	-0.4	1.1	-0.6	0.8
Long-standing illness, disability or infirmity	0.7	1.0	4.8	0.1	0.9	1.4	-0.5	1.5	2.2	0.7	0.5	0.4	0.5	-0.2
Breast cancer (self-reported)	0.7	0.9	2.6	1.6	-1.4	-0.8	0.8	-0.7	-0.9	-0.3	0.0	0.9	-0.1	1.2
Medication: Atorvastatin	0.7	0.9	2.6	-0.3	-0.2	0.6	-1.1	-0.4	-0.3	-0.9	-1.1	-1.6	-1.1	-1.5
Alcohol drinker status: Previous	0.7	0.8	3.5	1.2	0.0	-0.2	0.7	0.7	0.3	-0.1	0.3	1.9	1.1	1.3
Alzheimer’s Disease (in mother)	0.6	0.7	2.3	1.5	-0.1	-0.2	-0.2	-0.4	-0.7	-1.4	-0.8	0.7	-0.9	0.1
Fasting Glucose	0.6	0.7	2.6	1.6	-0.3	0.3	-0.7	-0.7	0.3	-1.0	-0.6	0.8	-0.9	-0.8
Respiratory disease	0.6	1.4	4.3	1.3	0.1	1.3	-1.4	0.4	0.9	-2.1	-1.6	0.3	-1.3	-0.7
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.4	-0.1	-1.1	-0.5	1.1	-0.3	0.3	1.2	1.1	1.1	1.0	1.2
Diabetes (father)	0.6	0.7	1.5	0.9	0.6	1.2	-0.8	1.0	1.1	-0.6	-0.6	0.2	-0.8	-0.7
Impedance of leg (right)	0.6	2.8	11.2	1.2	-3.3	-1.7	1.4	-1.0	-1.2	0.4	1.0	1.0	1.8	2.4
Forced vital capacity (FVC)	0.6	2.3	6.0	0.4	-2.4	-1.3	1.7	-0.9	-0.5	0.8	1.1	2.4	1.2	2.0
Pain all over the body in last month	0.6	0.7	1.7	-0.3	0.3	1.2	-1.3	0.5	0.9	-0.8	-1.1	-0.7	-0.5	-0.7
Diabetes (self-reported)	0.6	1.0	5.2	-1.2	-1.5	-0.1	-0.2	-2.3	-0.6	-0.5	-0.2	-0.8	-0.6	-0.6
Birth weight of first child	0.6	1.1	3.2	0.2	1.2	0.4	-1.0	0.4	-0.6	-1.8	-1.6	-0.3	-1.6	-0.8
Medication: Blood pressure	0.6	1.0	2.8	1.7	-0.4	1.1	-1.0	-0.6	0.7	-1.3	-1.2	-0.0	-1.0	-0.8
Whole body fat-free mass	0.6	3.3	7.3	0.0	-0.8	-0.9	2.2	0.1	0.8	2.7	2.4	2.7	2.2	2.1
Ever had bowel cancer screening	0.6	0.7	1.6	0.2	0.5	-0.5	1.0	0.5	-0.1	1.1	1.1	0.5	1.3	1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	2.7	-1.5	0.3	0.3	-0.6	0.2	-0.3	-0.1	-0.4	-1.7	-0.5	-1.3
Whole body water mass	0.6	3.3	7.5	-0.1	-0.8	-0.9	2.3	0.0	0.8	2.7	2.4	2.6	2.3	2.1
Medication: Paracetamol	0.6	1.0	2.2	1.5	-0.8	1.0	-1.1	0.5	0.6	-1.2	-1.0	-0.4	-1.2	-1.0
Basal metabolic rate	0.6	3.2	8.4	0.6	-1.0	-0.9	2.2	0.1	0.7	2.3	2.2	2.9	2.0	2.2
Unable to work because of sickness or disability	0.6	0.8	2.4	-1.3	-0.3	0.1	0.1	0.1	0.3	1.4	1.1	-1.5	1.0	0.3
Pain experienced in last month	0.6	0.9	4.6	-2.1	-0.3	-1.0	0.2	-0.3	-1.8	-0.6	-0.2	-0.6	-0.5	0.2
Supplements: Calcium	0.6	0.7	1.4	1.2	-1.0	-1.1	1.0	-0.7	-1.1	0.4	0.6	0.2	0.5	0.8
Impedance of whole body	0.6	2.9	10.2	2.3	-3.2	-1.6	1.2	-0.7	-1.5	-0.7	0.3	1.5	1.0	2.4
Major Depression (MDD)	0.5	0.7	1.9	0.0	1.4	1.0	-0.9	1.0	0.7	-0.4	-0.6	-0.9	-0.5	-0.7
Type 2 Diabetes (T2D) (2012)	0.5	0.5	2.7	-0.3	-1.7	-0.9	0.4	-1.0	-0.9	0.1	0.3	-0.3	0.1	0.3
Blood Red Count	0.5	4.8	9.1	-0.9	-0.7	-2.4	2.8	-0.4	-1.1	3.0	3.0	1.4	3.0	2.8
Hypothyroidism (self reported)	0.5	1.1	4.5	-0.7	-2.1	-0.4	-0.3	-2.1	-0.8	-0.9	-0.6	-0.9	-0.5	-0.3
Number of incorrect matches in round	0.5	0.8	2.1	-0.8	-0.3	-0.7	0.9	-0.2	-0.3	1.2	1.2	0.2	1.5	1.3
Allergy	0.5	1.1	3.3	-1.3	1.8	0.2	-0.2	0.4	0.2	1.4	0.6	-1.8	0.4	-1.0
Medication: Ramipril	0.5	0.6	3.6	-0.5	-0.2	1.3	-0.8	0.3	1.9	0.2	-0.1	0.2	0.4	-0.3
Illnesses of siblings	0.5	0.7	3.0	-1.7	0.8	0.1	0.0	0.5	0.4	1.2	0.6	-1.0	0.8	0.0
Weight	0.5	2.5	9.0	2.0	-1.4	-0.7	1.8	0.1	0.6	1.2	1.4	3.0	1.2	2.0
Impedance of arm (right)	0.5	2.3	9.9	3.1	-2.3	-0.2	-0.3	0.3	-0.6	-2.3	-1.3	1.2	-0.7	0.9
Arm fat percentage (right)	0.5	2.0	9.4	3.1	-0.1	0.9	-0.8	0.5	0.6	-1.9	-1.5	0.8	-1.8	-0.7
Forced expiratory volume in 1-second (FEV1)	0.5	1.8	4.6	0.3	-2.1	-1.1	1.6	-0.9	-0.4	1.0	1.1	2.0	1.0	1.7
Depression (self-reported)	0.5	0.6	1.5	1.2	-1.2	-0.5	0.9	0.2	-0.2	0.4	0.6	0.9	0.1	1.0
Impedance of arm (left)	0.5	2.1	8.1	2.8	-2.3	-0.5	-0.2	-0.2	-1.0	-2.2	-1.2	1.0	-0.7	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.4	1.0	-0.0	1.0	-0.7	1.2	0.9	-1.1	-0.9	0.8	-1.1	-0.3
Glaucoma (self-reported)	0.5	0.6	1.7	0.3	0.8	1.3	-1.0	0.8	1.3	-0.3	-0.7	-0.6	-0.2	-0.5
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	2.1	0.1	-1.3	0.1	-0.8	-1.4	-0.4	-1.3	-1.1	-1.1	-1.1	-0.8
Forced vital capacity (FVC), Best measure	0.5	1.7	7.0	0.1	-2.7	-1.1	1.4	-1.2	-0.7	0.7	0.8	1.5	0.9	1.5
Comparative height size at age 10	0.5	2.7	5.0	0.7	-2.2	-1.0	1.8	-0.4	0.4	1.9	1.8	1.8	2.2	2.0
Asthma (self-reported)	0.5	1.0	4.1	0.9	-0.4	0.9	-1.0	0.1	0.6	-2.0	-1.5	0.4	-1.3	-0.1
Osteoporosis (self-reported)	0.5	0.6	1.9	-0.5	0.3	0.6	-0.8	0.3	0.0	-0.7	-0.7	-1.0	-1.2	-1.4
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	2.7	-0.8	1.0	1.0	-0.4	0.6	1.6	0.9	0.2	-0.4	0.3	-0.3
Heart disease (siblings)	0.5	0.6	1.5	1.2	-0.4	-0.3	-0.1	-1.2	-0.8	-0.9	-0.5	-0.3	-1.0	-0.4
Bipolar Disorder (2018)	0.4	0.6	1.6	0.4	-1.1	-0.8	0.2	-1.3	-0.9	-1.0	-0.2	0.5	-0.7	0.0
Ulcerative Colitis (UC)	0.4	0.7	3.7	-1.9	0.2	-0.2	0.4	-0.4	-0.3	1.1	0.6	-0.9	0.6	-0.5
Reaction Time	0.4	0.7	1.7	-0.9	0.5	0.2	0.4	0.7	0.8	1.2	1.0	0.0	1.3	1.1
Ovarian Cancer	0.4	0.5	1.4	1.0	-0.2	0.1	0.4	1.1	0.6	0.4	0.4	1.2	0.6	0.9
Body Mass Index (BMI) (2010)	0.4	0.5	1.0	0.8	-0.1	0.1	-0.6	-0.8	-0.4	-0.8	-0.8	-0.8	-1.0	-1.0
HDL Cholesterol	0.4	0.6	1.4	0.2	0.0	1.2	-1.1	-0.1	0.9	-0.7	-0.9	-0.7	-0.9	-0.7
Vitamin and mineral supplements	0.4	0.5	2.5	-0.7	-0.5	-0.4	0.0	-0.9	-1.1	0.0	0.3	-1.6	-0.4	-0.0
Diabetes (mother)	0.4	0.5	0.9	0.9	0.0	0.9	-0.8	0.9	0.9	-0.6	-0.7	0.4	-0.7	-0.5
Trunk fat percentage	0.4	1.6	10.4	3.2	-1.5	-0.3	0.6	-0.1	-0.1	-0.8	-0.1	1.6	-0.3	1.0
Fed-up feelings	0.4	0.8	3.6	1.4	0.6	0.5	0.1	0.6	1.3	0.2	0.3	1.9	0.2	0.5
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	2.6	-0.0	0.2	0.6	-0.6	-0.9	0.4	0.3	-0.0	-1.6	0.0	-0.6
Trunk fat mass	0.4	1.9	6.9	2.6	-1.8	-0.8	1.3	-0.3	-0.1	0.1	0.7	2.1	0.4	1.6
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.8	2.9	1.7	0.9	-0.4	0.2	0.7	-0.7	-1.3	-0.8	1.1	-0.7	0.5
Worrier / anxious feelings	0.4	0.8	3.3	0.6	0.5	1.4	-1.2	1.0	1.8	-0.0	-0.4	-0.7	0.2	-0.3
Happiness	0.4	0.5	4.1	-2.0	0.6	-0.0	0.1	0.0	0.1	0.4	0.4	-0.3	0.6	0.2
Noisy workplace	0.4	0.4	1.4	-1.1	-0.0	0.2	0.2	-0.4	0.6	1.2	1.0	-0.6	0.5	-0.2
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	2.3	-0.5	0.1	0.0	-0.7	-0.2	-0.5	-1.5	-1.4	-0.1	-1.1	-0.4
Blood clot in the leg (DVT)	0.4	0.6	2.1	-0.8	1.0	0.8	-0.1	0.5	1.5	1.1	0.4	-0.3	0.5	-0.1
Comparative body size at age 10	0.4	1.1	3.3	0.8	1.7	0.8	-0.8	0.7	0.3	-1.2	-1.0	0.1	-1.8	-1.0
Number of full brothers	0.4	0.5	1.4	-0.8	-0.3	-0.0	-0.4	-0.7	-0.5	-0.8	-0.8	-1.1	-1.2	-0.7
Number of full sisters	0.4	0.5	2.3	1.5	-1.0	0.0	0.1	-0.5	-0.0	-0.7	-0.5	1.1	-0.4	0.1
Arm fat percentage (left)	0.4	1.7	7.7	2.8	-0.1	0.8	-0.8	0.2	0.4	-1.9	-1.5	0.6	-1.9	-0.8
Leg fat mass (left)	0.4	1.4	5.7	2.4	-1.0	-0.4	1.2	-0.1	0.3	0.3	0.7	2.2	0.3	1.2
Ulcerative Colitis	0.3	0.5	1.1	-1.1	0.8	0.8	-0.4	0.7	0.7	0.8	0.1	-0.6	0.1	-0.9
Leg fat-free mass (left)	0.3	1.3	6.5	1.1	-0.4	-0.1	1.2	0.4	1.0	1.0	1.0	2.5	0.8	1.1
Maternal smoking around birth	0.3	0.4	2.8	0.5	1.7	-0.0	0.3	0.6	0.1	0.5	0.4	0.2	0.5	0.6
Relative age voice broke	0.3	0.5	2.3	-0.4	-0.6	0.2	-0.6	-1.5	-0.2	0.0	-0.3	-1.3	-0.3	-0.5
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.2	-1.1	-0.1	0.2	-0.4	-0.2	-0.1	-0.1	-0.4	-1.0	-0.4	-0.4
Medication: Atenolol	0.3	0.4	1.0	0.5	0.7	-0.1	0.4	0.5	0.2	1.0	0.9	-0.1	0.8	0.5
Chronic bronchitis/emphysema (father)	0.3	0.3	1.2	0.5	0.1	0.4	-0.7	-0.0	0.3	-1.1	-0.8	0.1	-0.8	-0.5
Hair/balding pattern: Pattern 2	0.3	0.3	0.9	0.2	0.3	0.9	-0.7	0.1	1.0	0.3	0.1	-1.0	-0.1	-0.6
Had menopause	0.3	0.4	1.4	0.2	0.9	0.8	-0.6	1.2	0.9	0.2	0.2	-0.3	-0.0	-0.3
Hair/balding pattern: Pattern 3	0.3	0.4	1.8	-0.1	1.3	0.3	-0.5	0.0	0.0	-0.9	-0.9	0.4	-0.7	-0.6
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.6	-1.1	0.2	0.3	-0.8	-0.5	-0.2	-1.2	-1.3	-0.6	-1.2	-1.0
Lung cancer (father)	0.3	0.4	1.1	0.3	-1.0	-0.4	0.4	-0.8	-0.0	-0.1	0.6	0.8	0.4	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	4.8	0.4	-2.2	-0.7	0.9	-1.0	-0.5	0.2	0.3	1.4	0.2	1.0
Arm fat mass (right)	0.3	1.2	7.3	2.7	-0.3	0.4	0.1	0.4	0.7	-0.8	-0.5	1.8	-0.8	0.2
Peak expiratory flow (PEF)	0.3	0.8	3.5	0.9	-1.9	-0.4	0.7	-0.7	0.1	0.3	0.3	1.5	0.2	0.7
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.2	-1.1	0.0	-0.7	0.7	0.2	-0.7	0.4	0.6	-0.2	0.6	0.8
Body fat percentage	0.3	1.2	8.7	3.0	-1.1	-0.1	0.3	-0.2	0.0	-0.9	-0.3	1.3	-0.6	0.6
Emphysema/chronic bronchitis	0.3	0.4	1.3	0.3	0.7	0.9	-0.4	1.0	1.1	0.5	0.0	0.1	0.4	-0.1
Medication: Ibuprofen	0.3	0.4	0.8	0.6	-0.1	0.6	-0.8	-0.9	0.4	-0.6	-0.5	-0.5	-0.5	-0.8
Whole body fat mass	0.3	1.3	6.4	2.5	-1.3	-0.5	1.0	-0.4	0.0	-0.1	0.4	1.8	-0.1	1.1
Leg fat mass (right)	0.3	1.3	6.9	2.6	-1.1	-0.3	0.9	-0.2	0.3	-0.1	0.3	2.0	-0.1	0.9
Alcohol intake frequency.	0.3	0.8	2.8	0.8	1.1	0.7	0.2	0.9	1.7	0.6	0.5	1.2	0.7	0.4
Overall health rating	0.3	0.8	4.0	2.0	0.3	0.9	-0.7	0.8	1.2	-0.4	-0.5	0.5	-0.3	-0.2
Commuting to job workplace: Car/motor vehicle	0.3	0.3	2.2	1.5	-0.2	0.2	-0.2	0.5	0.5	0.1	-0.0	0.6	0.5	0.3
Leg fat-free mass (right)	0.3	1.7	7.0	0.9	-0.4	-0.3	1.5	0.4	1.0	1.4	1.4	2.6	1.1	1.4
Back pain experienced in last month	0.3	0.4	1.6	0.0	0.4	0.2	0.2	-0.1	0.7	1.2	0.9	-0.3	1.0	-0.0
Leg predicted mass (right)	0.3	1.8	7.3	0.9	-0.4	-0.3	1.5	0.5	1.0	1.5	1.4	2.7	1.2	1.5
Average weekly champagne plus white wine intake	0.3	0.4	1.8	-1.4	0.8	-0.2	-0.1	0.1	-0.3	0.3	-0.0	-1.0	0.1	-0.1
Leg fat percentage (left)	0.3	1.0	5.3	2.3	-0.9	-0.4	0.8	-0.1	0.0	-0.1	0.3	1.6	0.0	1.1
Irritability	0.3	0.5	1.2	1.1	-0.3	0.1	0.3	0.4	0.7	0.6	0.5	1.0	0.8	0.7
Risk taking	0.3	0.5	1.0	0.1	0.5	0.8	-0.8	0.7	0.2	-0.6	-0.8	-1.0	-0.6	-0.9
Fractured/broken bones in last 5 years	0.3	0.4	1.1	0.1	0.4	0.8	-0.8	0.0	1.1	0.3	-0.1	-0.8	-0.1	-1.0
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.7	0.4	0.8	0.8	-0.8	0.1	0.7	-0.4	-0.6	-0.7	-0.5	-0.4
Basal cell carcinoma (self-reported)	0.3	0.3	1.0	0.3	-0.2	-0.8	0.4	-0.6	-1.0	-0.8	-0.0	0.3	-0.5	0.6
Bipolar Disorder or Schizophrenia	0.2	0.5	1.4	0.3	-1.2	-0.6	0.1	-1.1	-0.9	-1.0	-0.4	0.3	-0.6	0.2
Depression (Nagel 2018)	0.2	0.2	1.1	0.3	-1.0	-0.3	0.5	-0.4	-0.1	0.6	0.5	0.3	0.4	0.5
Alzheimer’s Disease (in father)	0.2	0.2	0.5	0.4	0.5	-0.2	0.0	-0.5	-0.3	-0.7	-0.4	0.7	-0.3	0.4
Schizophrenia (2014)	0.2	0.5	1.8	0.0	-0.8	-0.3	-0.1	-0.7	-1.0	-1.3	-0.9	-0.0	-0.9	-0.2
Lung FVC	0.2	1.0	3.5	0.1	0.5	1.3	-1.4	-0.1	0.7	-0.5	-0.9	-0.9	-1.1	-1.9
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.6	1.2	0.4	-0.1	0.5	1.3	0.2	-0.3	-0.1	1.2	0.3	0.8
Qualifications: CSEs or equivalent	0.2	0.3	1.0	1.0	-0.4	0.2	0.2	-0.3	0.8	0.3	0.2	1.0	0.5	0.4
Multivitamins +/- minerals	0.2	0.2	1.4	0.4	-0.1	-0.3	0.5	-0.2	0.1	-0.1	0.1	1.2	0.2	0.6
Body mass index (BMI)	0.2	0.8	2.5	1.6	0.9	0.8	-0.4	0.5	0.9	-0.7	-0.6	0.7	-1.2	-0.7
Leg predicted mass (left)	0.2	1.3	6.1	1.2	-0.3	0.0	1.1	0.5	1.1	1.0	1.0	2.5	0.8	1.1
Heart attack	0.2	0.2	0.9	0.2	0.9	0.1	0.2	0.2	0.3	0.1	0.1	0.7	0.5	0.6
Time employed in main current job	0.2	0.2	0.4	-0.7	0.1	0.2	-0.6	0.4	0.2	-0.0	-0.5	-0.6	-0.3	-0.7
Alcohol intake versus 10 years previously	0.2	0.3	1.1	0.3	0.7	0.7	-0.3	0.6	1.0	0.5	0.1	-0.3	0.0	-0.6
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.7	0.3	0.1	0.8	-0.7	-0.5	0.8	-0.1	-0.2	-0.6	-0.1	-0.7
Length of working week for main job	0.2	0.2	1.2	-0.7	1.1	0.1	-0.3	0.7	0.1	-0.3	-0.3	0.2	-0.2	-0.3
Medication: Paracetamol	0.2	0.3	1.4	0.9	-1.2	0.2	-0.2	-0.0	-0.0	-0.4	-0.2	-0.4	-0.7	-0.4
Headache pain in last month	0.2	0.3	0.5	0.7	-0.2	0.6	-0.5	-0.2	0.7	-0.4	-0.4	-0.5	-0.6	-0.7
Leg fat percentage (right)	0.2	0.9	6.5	2.6	-0.8	0.0	0.2	-0.1	0.1	-0.8	-0.4	1.1	-0.7	0.3
Qualifications: College or University degree	0.2	0.6	1.6	-1.3	-0.1	0.5	-0.8	-0.3	-0.1	-0.6	-0.8	-0.8	-1.0	-1.2
Eye problems/disorders: None of the above	0.2	0.2	1.1	1.0	-0.2	0.2	-0.3	0.9	0.3	-0.2	-0.3	0.5	0.0	-0.3
Neck or shoulder pain in last month	0.2	0.3	1.2	0.9	-0.6	0.2	-0.0	-1.1	0.5	0.3	0.2	0.0	-0.0	-0.4
Medication: Omeprazole	0.2	0.2	0.5	0.2	0.5	0.6	-0.5	-0.0	0.6	0.1	-0.3	-0.7	-0.1	-0.3
Had major operations	0.2	0.2	0.9	-0.5	-0.4	0.2	-0.2	-0.9	-0.1	-0.0	-0.1	-0.7	-0.6	-0.7
Supplements: Vitamin C	0.2	0.3	0.6	0.3	0.7	0.4	-0.2	0.8	0.5	-0.4	-0.5	0.7	-0.2	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.0	0.3	-1.0	0.0	0.3	0.6	0.7	0.7	0.3	0.7	1.0	0.6
Commuting to job workplace: Walk	0.2	0.2	0.7	0.8	-0.3	0.2	-0.1	0.1	0.2	-0.5	-0.3	0.8	-0.3	-0.2
Eye problems/disorders: Cataract	0.2	0.2	0.7	-0.6	0.8	0.3	-0.2	0.0	0.2	-0.5	-0.3	-0.1	-0.8	-0.3
Osteoarthritis (self-reported)	0.2	0.3	0.7	-0.4	-0.3	-0.1	0.4	-0.1	0.4	0.8	0.7	0.4	0.8	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.7	-0.4	-0.7	-0.3	0.0	-0.9	-0.9	-0.8	-0.6	-0.1	-1.3	-0.4
Arm fat mass (left)	0.2	0.9	5.7	2.4	-0.5	0.1	0.3	0.0	0.4	-0.5	-0.2	1.6	-0.6	0.3
Ever taken oral contraceptive pill	0.2	0.3	1.2	0.7	0.4	0.3	0.1	0.1	0.9	-0.0	0.0	1.1	0.3	0.1
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.8	0.5	-0.3	-0.4	0.5	0.3	-0.2	0.9	0.9	-0.2	0.3	0.5
Eye problems/disorders: Glaucoma	0.2	0.2	0.7	0.4	0.0	0.5	-0.2	0.8	0.8	0.1	-0.2	0.3	0.4	0.4
Pain type(s) experienced in last month: Hip pain	0.2	0.3	1.1	1.1	0.6	0.6	-0.2	0.3	0.9	0.1	-0.1	0.3	-0.2	-0.5
Ever smoked	0.2	0.3	0.9	1.0	-0.3	-0.3	0.5	0.0	-0.2	0.8	0.6	0.3	0.9	0.3
Heart attack/myocardial infarction (self-reported)	0.2	0.3	1.0	0.2	1.0	0.1	0.3	0.2	0.5	0.3	0.2	0.8	0.6	0.7
Schizophrenia (2018)	0.1	0.1	0.4	0.2	-0.7	-0.2	0.0	-0.4	-0.3	-0.5	-0.3	0.0	-0.2	0.3
BMI	0.1	0.7	2.4	1.6	0.7	0.6	-0.1	0.5	0.8	-0.8	-0.5	1.5	-0.8	-0.1
Smoking Status	0.1	0.3	0.5	0.6	-0.2	-0.2	-0.5	-0.6	-0.6	-0.4	-0.4	-0.6	-0.4	-0.7
Lung FEV1/FVC ratio	0.1	0.4	1.8	0.2	1.3	0.5	-0.2	1.1	0.9	0.6	0.1	-0.2	-0.3	-0.1
Hair Pigment	0.1	1.4	5.5	1.0	1.9	1.4	-1.1	2.3	1.4	0.1	-0.0	-0.7	0.1	-0.5
Relative age of first facial hair	0.1	0.3	1.1	-0.3	-0.1	-0.1	0.2	-0.1	0.3	0.9	0.7	-0.0	1.1	0.6
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.3	0.4	0.4	-0.3	0.3	0.3	-0.3	-0.2	0.1	0.6	-0.2	-0.0
Age when periods started (menarche)	0.1	0.3	1.4	0.6	0.0	-0.3	0.4	0.6	-0.4	-0.3	-0.1	0.5	0.4	1.2
Waist circumference	0.1	0.3	1.5	1.2	0.1	0.5	0.2	0.3	0.9	0.5	0.4	0.6	-0.1	0.2
Past tobacco smoking	0.1	0.2	1.6	-1.2	-0.0	0.0	-0.1	-0.2	-0.1	-0.4	-0.3	-0.1	-0.6	0.1
Falls in the last year	0.1	0.2	0.4	-0.3	-0.6	0.2	-0.2	-0.5	-0.0	-0.3	-0.5	-0.2	-0.5	-0.6
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.2	-0.2	-0.3	-0.2	0.0	-0.3	-0.5	-0.4	-0.1	0.1	-0.4	-0.2
Birth weight	0.1	0.1	0.9	0.3	0.2	-0.6	0.4	0.0	-0.9	0.2	0.3	-0.2	-0.1	0.1
Chronic bronchitis/emphysema (mother)	0.1	0.2	0.5	-0.7	0.4	-0.2	0.1	-0.1	-0.6	0.2	-0.2	-0.6	0.1	-0.5
Shortness of breath walking on level ground	0.1	0.1	0.4	0.2	0.7	0.3	0.0	0.3	0.5	-0.4	-0.1	0.5	-0.3	0.1
Migraine (self-reported)	0.1	0.1	1.1	1.0	-0.1	0.2	-0.1	0.3	0.2	-0.1	-0.1	0.4	-0.2	-0.2
Illnesses of siblings: Diabetes	0.1	0.1	0.4	0.6	-0.5	0.0	-0.0	-0.4	0.1	-0.0	0.1	0.2	-0.1	-0.2
Smoking status: Previous	0.1	0.2	1.2	1.1	-0.4	-0.2	0.1	-0.3	0.0	0.3	0.3	0.3	0.6	0.1
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.9	-0.1	0.5	-0.6	0.3	0.1	-0.9	-0.1	-0.1	0.1	0.0	0.2
Medication: Gliclazide	0.1	0.1	0.8	-0.9	0.4	0.1	-0.2	-0.2	-0.0	-0.2	-0.1	0.1	-0.4	-0.5
Smoking status: Current	0.1	0.1	0.4	-0.3	0.3	-0.2	0.1	-0.2	-0.4	0.4	0.2	-0.6	0.0	-0.4
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.9	1.0	-0.8	0.2	-0.1	-0.2	0.4	0.0	0.2	0.3	-0.0	-0.2
Number of operations (self-reported)	0.1	0.1	0.6	-0.2	0.2	-0.2	0.4	-0.0	-0.2	0.8	0.5	-0.4	0.3	-0.0
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Tanning	0.0	0.5	1.5	-0.7	-0.4	-0.3	0.8	-1.1	0.1	1.2	1.2	0.1	0.5	-0.0
Current tobacco smoking	0.0	0.1	0.3	-0.2	0.1	-0.1	-0.0	-0.4	-0.4	0.1	-0.0	-0.6	-0.1	-0.4

Hub : Genes

LETMD1

Models

Trait associations