Hub : Genes

LETMD1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1080	0.0380	4.7e-05	0.043	0.033	0.015	0.033	0.025	4.7e-06	6.0e-05	5.3e-03	5.9e-05	4.4e-04
2	GTEx	Adipose Subcutaneous	0.0590	0.0260	3.8e-03	0.005	NA	0.003	NA	0.003	1.1e-01	NA	1.7e-01	NA	1.9e-01
3	GTEx	Lung	0.0781	0.0296	5.9e-04	0.073	NA	0.062	NA	0.083	2.8e-06	NA	1.7e-05	NA	6.8e-07
4	GTEx	Muscle Skeletal	0.0996	0.0333	4.2e-06	0.065	NA	0.074	NA	0.008	5.4e-07	NA	9.4e-08	NA	4.6e-02
5	NTR	Blood	0.0235	0.0087	6.0e-05	0.016	0.012	0.007	0.012	0.012	4.1e-06	8.3e-05	2.4e-03	5.9e-05	8.1e-05
6	YFS	Blood	0.0505	0.0145	1.9e-09	0.039	0.037	0.052	0.045	0.053	9.2e-13	4.3e-12	1.6e-16	2.1e-14	9.9e-17
7	TCGA	Breast Invasive Carcinoma	0.0158	0.0094	1.8e-03	0.008	0.009	0.006	NA	0.009	6.6e-03	4.4e-03	1.5e-02	NA	5.2e-03
8	TCGA	Head and Neck Squamous Cell Carcinoma	0.0477	0.0254	4.8e-05	0.038	0.039	0.045	NA	0.044	3.9e-05	2.8e-05	8.2e-06	NA	8.8e-06
9	TCGA	Kidney Renal Clear Cell Carcinoma	0.0327	0.0186	5.9e-03	0.003	0.018	0.005	NA	0.008	1.5e-01	3.8e-03	8.0e-02	NA	4.2e-02
10	TCGA	Lung Squamous Cell Carcinoma	0.0284	0.0174	2.8e-03	0.022	0.016	0.014	NA	0.021	1.2e-03	5.2e-03	7.9e-03	NA	1.9e-03
11	TCGA	Prostate Adenocarcinoma	0.0305	0.0198	4.7e-03	0.026	0.016	0.009	NA	0.014	8.1e-04	7.4e-03	3.6e-02	NA	1.3e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.4	0.6	1.6	0.4	-1.1	-0.8	0.2	-1.3	-0.9	-1.0	-0.2	0.5	-0.7	0.0
Bipolar Disorder or Schizophrenia	0.2	0.5	1.4	0.3	-1.2	-0.6	0.1	-1.1	-0.9	-1.0	-0.4	0.3	-0.6	0.2
Depressed Affect (Nagel 2018)	1.4	3.0	8.4	2.4	1.1	1.3	0.1	2.7	2.6	0.4	0.4	2.9	0.4	1.1
Depression (Nagel 2018)	0.2	0.2	1.1	0.3	-1.0	-0.3	0.5	-0.4	-0.1	0.6	0.5	0.3	0.4	0.5
Intelligence (Savage-Jansen 2018)	1.2	3.6	7.2	-0.8	1.0	1.8	-2.4	0.3	0.5	-2.1	-2.5	-2.3	-2.4	-2.7
Neuroticism (Nagel 2018)	1.6	3.8	12.7	2.7	1.3	2.1	-1.1	3.6	3.1	-0.6	-0.6	2.0	-0.5	0.2
Schizophrenia (2018)	0.1	0.1	0.4	0.2	-0.7	-0.2	0.0	-0.4	-0.3	-0.5	-0.3	0.0	-0.2	0.3
Schizophrenia vs Biploar Disorder	2.5	3.3	4.9	-2.1	-1.6	-2.0	2.0	-1.1	-1.9	1.9	1.9	-0.6	2.0	2.2
Worry (Nagel 2018)	0.9	1.9	7.8	1.7	0.6	1.4	-0.8	2.8	2.2	-0.1	-0.4	1.2	0.4	0.5
Alzheimer’s Disease (in mother)	0.6	0.7	2.3	1.5	-0.1	-0.2	-0.2	-0.4	-0.7	-1.4	-0.8	0.7	-0.9	0.1
Alzheimer’s Disease (in father)	0.2	0.2	0.5	0.4	0.5	-0.2	0.0	-0.5	-0.3	-0.7	-0.4	0.7	-0.3	0.4
Alzheimer’s Disease (including proxy)	0.8	1.2	3.5	1.4	-0.3	-0.7	0.0	-1.1	-1.4	-1.9	-1.0	0.7	-1.3	0.3
Crohns Disease (2017)	2.0	4.4	8.0	-2.1	-1.6	-2.7	2.6	-2.8	-2.7	1.3	1.8	0.8	1.5	2.1
Irritable Bowel Disease (IBD)	0.8	2.0	5.5	-2.3	-0.6	-1.6	1.6	-1.9	-1.9	1.2	1.2	-0.2	0.9	0.6
Ulcerative Colitis (UC)	0.4	0.7	3.7	-1.9	0.2	-0.2	0.4	-0.4	-0.3	1.1	0.6	-0.9	0.6	-0.5
Major Depression (MDD)	0.5	0.7	1.9	0.0	1.4	1.0	-0.9	1.0	0.7	-0.4	-0.6	-0.9	-0.5	-0.7
Reaction Time	0.4	0.7	1.7	-0.9	0.5	0.2	0.4	0.7	0.8	1.2	1.0	0.0	1.3	1.1
Verbal and Numeric Reasoning (VNR)	1.7	4.2	8.7	-0.9	1.4	2.1	-2.7	0.5	1.0	-2.1	-2.6	-2.1	-2.5	-2.9
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	0.4	0.5	1.4	1.0	-0.2	0.1	0.4	1.1	0.6	0.4	0.4	1.2	0.6	0.9
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	2.1	3.0	4.8	-0.6	-2.2	-1.6	2.1	-1.1	-0.5	1.8	2.2	1.8	2.0	2.0
Bipolar Disorder (2011)	2.5	2.4	7.5	2.7	-0.7	0.6	-1.2	-0.1	-0.3	-2.3	-1.9	0.0	-2.4	-1.4
Body Mass Index (BMI) (2010)	0.4	0.5	1.0	0.8	-0.1	0.1	-0.6	-0.8	-0.4	-0.8	-0.8	-0.8	-1.0	-1.0
Coronary Artery Disease (CAD)	1.3	1.5	3.6	-0.3	0.6	1.0	-1.6	0.2	-0.0	-1.0	-1.6	-1.9	-1.4	-1.9
Crohns Disease (2012)	1.0	1.6	5.3	-1.4	-1.2	-1.6	1.3	-2.3	-1.8	0.2	0.7	0.3	0.0	0.7
Mean Putamen Volume	0.9	1.0	3.2	1.7	0.2	0.9	-0.6	1.8	1.2	-0.7	-0.9	1.1	-0.3	-0.1
Fasting Glucose	0.6	0.7	2.6	1.6	-0.3	0.3	-0.7	-0.7	0.3	-1.0	-0.6	0.8	-0.9	-0.8
HbA1C	4.0	4.5	9.2	-0.2	1.3	2.1	-2.8	-0.2	0.7	-2.0	-2.5	-2.9	-2.7	-3.0
HDL Cholesterol	0.4	0.6	1.4	0.2	0.0	1.2	-1.1	-0.1	0.9	-0.7	-0.9	-0.7	-0.9	-0.7
LDL Cholesterol	0.8	1.3	4.2	0.1	2.0	1.5	-1.2	1.1	1.4	-0.1	-0.6	-0.9	-0.4	-1.2
Lupus	1.0	1.5	4.0	-0.9	-2.0	-1.3	0.9	-1.3	-1.2	1.1	1.0	-0.4	1.3	1.4
Neuroticism (2016)	0.8	1.2	3.4	1.8	-0.1	0.8	-0.2	1.7	1.6	-0.1	0.1	1.8	0.2	0.5
Primary Biliary Cirrhosis	0.9	1.3	4.6	1.0	0.5	0.8	-1.2	0.4	0.1	-2.1	-1.6	-0.0	-1.7	-0.8
Rheumatoid Arthritis	1.2	1.7	8.2	2.9	-0.9	-0.5	0.6	-0.0	-0.3	-1.1	-0.2	2.4	-0.6	1.1
Schizophrenia (2014)	0.2	0.5	1.8	0.0	-0.8	-0.3	-0.1	-0.7	-1.0	-1.3	-0.9	-0.0	-0.9	-0.2
Triglycerides	0.9	1.4	6.6	-1.9	0.1	0.4	-1.3	-0.6	-0.5	-0.5	-0.7	-2.6	-0.6	-1.4
Type 2 Diabetes (T2D) (2012)	0.5	0.5	2.7	-0.3	-1.7	-0.9	0.4	-1.0	-0.9	0.1	0.3	-0.3	0.1	0.3
Ulcerative Colitis	0.3	0.5	1.1	-1.1	0.8	0.8	-0.4	0.7	0.7	0.8	0.1	-0.6	0.1	-0.9
Blood Eosinophil Count	1.9	14.4	26.7	-0.2	4.1	3.2	-4.5	0.3	0.5	-4.2	-4.6	-4.6	-5.2	-5.0
Blood Platelet Count	1.2	13.4	23.6	-2.5	4.9	3.2	-4.1	-1.1	0.8	-4.5	-4.4	-2.5	-4.8	-4.6
Blood Red Count	0.5	4.8	9.1	-0.9	-0.7	-2.4	2.8	-0.4	-1.1	3.0	3.0	1.4	3.0	2.8
Blood White Count	3.4	25.1	53.7	-1.3	0.9	3.3	-5.7	-3.1	-0.8	-6.5	-6.7	-5.9	-7.3	-6.7
Heel T-Score	0.8	6.2	20.1	2.3	-1.3	-2.7	3.0	0.7	-2.0	0.2	1.4	3.9	1.8	4.5
BMI	0.1	0.7	2.4	1.6	0.7	0.6	-0.1	0.5	0.8	-0.8	-0.5	1.5	-0.8	-0.1
Height	1.5	29.5	56.8	1.6	-6.5	-4.9	6.7	-1.5	-1.7	5.3	6.0	6.2	6.7	7.5
Waist Hip Ratio (WHR)	0.7	3.0	10.1	-0.9	2.4	1.6	-2.0	0.9	0.7	-0.1	-1.2	-3.2	-0.9	-2.3
Systolic Blood Pressure	0.8	3.9	14.4	3.8	-1.9	2.0	-2.2	1.5	1.6	-1.7	-2.1	-0.4	-1.2	-1.4
Smoking Status	0.1	0.3	0.5	0.6	-0.2	-0.2	-0.5	-0.6	-0.6	-0.4	-0.4	-0.6	-0.4	-0.7
Allergy or Eczema	0.9	2.5	8.9	-0.8	-3.0	-1.8	1.6	-2.0	-1.6	0.4	1.3	0.7	0.8	1.7
Cardiovascular Disease	2.5	8.3	14.9	3.9	1.8	3.7	-3.3	3.5	3.2	-2.3	-2.8	-0.4	-2.3	-2.7
Hypothyroidism (self reported)	0.5	1.1	4.5	-0.7	-2.1	-0.4	-0.3	-2.1	-0.8	-0.9	-0.6	-0.9	-0.5	-0.3
Respiratory disease	0.6	1.4	4.3	1.3	0.1	1.3	-1.4	0.4	0.9	-2.1	-1.6	0.3	-1.3	-0.7
Type 2 Diabetes (T2D) (2018)	0.7	1.3	3.6	-1.8	-1.3	0.0	-0.5	-1.9	-0.7	-0.4	-0.1	-1.8	-0.8	-0.8
Lung FEV1/FVC ratio	0.1	0.4	1.8	0.2	1.3	0.5	-0.2	1.1	0.9	0.6	0.1	-0.2	-0.3	-0.1
Lung FVC	0.2	1.0	3.5	0.1	0.5	1.3	-1.4	-0.1	0.7	-0.5	-0.9	-0.9	-1.1	-1.9
Neuroticism	1.8	4.3	11.5	2.8	1.3	2.5	-1.7	3.1	3.4	-1.0	-1.3	2.0	-0.8	-0.6
Chronotype (morning person)	1.3	3.0	5.9	0.6	-2.2	-1.6	2.3	-1.5	-0.6	1.7	2.0	2.4	1.4	1.5
Hair Pigment	0.1	1.4	5.5	1.0	1.9	1.4	-1.1	2.3	1.4	0.1	-0.0	-0.7	0.1	-0.5
Tanning	0.0	0.5	1.5	-0.7	-0.4	-0.3	0.8	-1.1	0.1	1.2	1.2	0.1	0.5	-0.0
Hand grip strength (left)	1.0	2.6	5.5	-1.3	-2.3	-2.2	1.7	-2.3	-2.0	1.2	1.3	0.2	0.9	0.9
Number of treatments/medications taken	2.0	3.6	7.0	1.4	0.8	2.6	-2.5	1.3	2.3	-1.6	-1.8	-1.2	-1.9	-2.4
Average weekly spirits intake	1.2	1.4	4.9	0.4	1.7	1.7	-0.9	1.9	2.2	0.6	0.1	0.2	0.1	-0.7
Sensitivity / hurt feelings	1.2	2.1	4.3	1.3	1.0	1.6	-1.7	2.1	1.7	-1.6	-1.6	0.2	-1.2	-0.8
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.4	-0.1	-1.1	-0.5	1.1	-0.3	0.3	1.2	1.1	1.1	1.0	1.2
Hearing difficulty/problems: Yes	2.0	3.0	7.9	2.8	1.5	1.6	-1.7	2.0	0.7	-2.0	-1.9	-0.2	-1.9	-1.4
Relative age of first facial hair	0.1	0.3	1.1	-0.3	-0.1	-0.1	0.2	-0.1	0.3	0.9	0.7	-0.0	1.1	0.6
Other serious medical condition/disability diagnosed by doctor	2.1	2.7	9.5	-0.1	2.1	2.5	-1.5	2.1	3.1	0.3	-0.4	-0.4	-0.2	-1.6
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.3	0.4	0.4	-0.3	0.3	0.3	-0.3	-0.2	0.1	0.6	-0.2	-0.0
Ever had hysterectomy (womb removed)	1.0	1.1	2.5	1.2	-0.7	-1.2	1.2	-0.2	-1.1	0.3	0.7	1.6	0.6	1.5
Systolic blood pressure, automated reading	1.0	2.8	10.7	3.3	-0.7	1.8	-1.7	2.2	1.9	-1.3	-1.5	0.5	-0.7	-0.6
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	4.9	-0.6	-1.1	-1.2	0.5	-2.2	-2.0	-0.6	-0.1	-0.7	-0.5	-0.1
Angina	1.3	1.8	4.2	0.5	2.1	1.8	-1.5	1.2	1.8	0.5	-0.3	-1.6	-0.0	-1.4
Medication for hormone replacement therapy	0.8	0.9	4.3	0.7	1.7	0.6	-0.3	2.1	0.9	-0.4	-0.5	1.0	-0.1	-0.1
Vitamin and mineral supplements	0.4	0.5	2.5	-0.7	-0.5	-0.4	0.0	-0.9	-1.1	0.0	0.3	-1.6	-0.4	-0.0
Supplements: Zinc	0.7	0.8	2.7	-1.2	-1.1	-1.0	0.5	-1.6	-1.1	0.1	-0.1	-0.8	0.0	-0.3
Medication: Co-codamol	1.5	1.8	3.5	-0.6	-1.7	-1.0	1.4	-1.5	-0.1	1.4	1.5	1.2	1.9	1.5
Medication: Metformin	0.7	1.0	4.6	-0.7	-1.4	-0.0	-0.5	-2.1	-0.7	-0.9	-0.6	-0.8	-1.0	-0.8
Diabetes (father)	0.6	0.7	1.5	0.9	0.6	1.2	-0.8	1.0	1.1	-0.6	-0.6	0.2	-0.8	-0.7
Diabetes (mother)	0.4	0.5	0.9	0.9	0.0	0.9	-0.8	0.9	0.9	-0.6	-0.7	0.4	-0.7	-0.5
Severe depression (siblings)	5.8	6.5	15.0	0.9	1.9	3.0	-3.4	1.4	1.9	-1.9	-2.6	-2.9	-2.6	-3.9
Pack years adult smoking proportion	1.2	1.8	3.4	-1.0	-1.1	-1.5	1.5	-1.2	-1.2	1.8	1.7	-0.7	1.5	1.2
Impedance of leg (right)	0.6	2.8	11.2	1.2	-3.3	-1.7	1.4	-1.0	-1.2	0.4	1.0	1.0	1.8	2.4
Leg fat-free mass (left)	0.3	1.3	6.5	1.1	-0.4	-0.1	1.2	0.4	1.0	1.0	1.0	2.5	0.8	1.1
Trunk fat percentage	0.4	1.6	10.4	3.2	-1.5	-0.3	0.6	-0.1	-0.1	-0.8	-0.1	1.6	-0.3	1.0
Hand grip strength (right)	1.2	3.2	7.6	-1.5	-2.5	-2.3	1.8	-2.8	-2.2	1.2	1.3	0.0	1.2	1.2
Townsend deprivation index at recruitment	2.6	3.7	9.5	0.2	-1.2	-1.8	2.5	-0.6	-0.8	1.6	2.1	2.5	2.4	3.1
Current tobacco smoking	0.0	0.1	0.3	-0.2	0.1	-0.1	-0.0	-0.4	-0.4	0.1	-0.0	-0.6	-0.1	-0.4
Average weekly fortified wine intake	0.8	1.0	1.9	-0.8	1.4	1.2	-1.0	0.7	1.2	-0.1	-0.3	-1.2	-0.6	-1.3
Maternal smoking around birth	0.3	0.4	2.8	0.5	1.7	-0.0	0.3	0.6	0.1	0.5	0.4	0.2	0.5	0.6
Fed-up feelings	0.4	0.8	3.6	1.4	0.6	0.5	0.1	0.6	1.3	0.2	0.3	1.9	0.2	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.3	4.2	-0.3	-2.0	-1.8	1.9	-1.6	-1.4	1.3	1.8	0.8	1.1	1.8
Relative age voice broke	0.3	0.5	2.3	-0.4	-0.6	0.2	-0.6	-1.5	-0.2	0.0	-0.3	-1.3	-0.3	-0.5
Taking other prescription medications	2.0	3.1	8.4	0.7	1.6	2.7	-2.1	2.1	2.9	-0.5	-1.1	-1.2	-0.7	-1.7
Age when periods started (menarche)	0.1	0.3	1.4	0.6	0.0	-0.3	0.4	0.6	-0.4	-0.3	-0.1	0.5	0.4	1.2
Bilateral oophorectomy (both ovaries removed)	1.7	1.9	3.5	0.2	-1.5	-1.9	1.8	-0.9	-1.6	0.7	1.1	1.6	1.1	1.7
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.6	1.2	0.4	-0.1	0.5	1.3	0.2	-0.3	-0.1	1.2	0.3	0.8
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.2	-1.1	-0.1	0.2	-0.4	-0.2	-0.1	-0.1	-0.4	-1.0	-0.4	-0.4
Qualifications: CSEs or equivalent	0.2	0.3	1.0	1.0	-0.4	0.2	0.2	-0.3	0.8	0.3	0.2	1.0	0.5	0.4
Serious illness, injury or assault to yourself	2.7	3.3	9.8	1.8	2.1	2.5	-1.4	2.6	3.1	-0.5	-1.0	1.3	-0.6	-1.2
High blood pressure	2.2	6.1	15.7	4.0	0.4	3.0	-2.7	2.3	2.6	-2.4	-2.5	-0.0	-2.3	-2.5
Hayfever, allergic rhinitis or eczema	1.2	2.6	8.6	0.3	-2.9	-1.8	1.6	-1.7	-1.6	-0.3	0.8	1.9	0.6	2.0
Multivitamins +/- minerals	0.2	0.2	1.4	0.4	-0.1	-0.3	0.5	-0.2	0.1	-0.1	0.1	1.2	0.2	0.6
Stomach or abdominal pain in last month	1.1	1.4	2.6	0.4	-0.1	-0.0	1.2	1.0	1.1	1.4	1.5	1.6	1.5	1.5
Supplements: Glucosamine	1.7	2.2	4.1	0.2	-1.2	-1.1	1.8	-0.3	0.0	1.9	1.9	2.0	1.9	1.8
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	2.6	-0.0	0.2	0.6	-0.6	-0.9	0.4	0.3	-0.0	-1.6	0.0	-0.6
Medication: Atenolol	0.3	0.4	1.0	0.5	0.7	-0.1	0.4	0.5	0.2	1.0	0.9	-0.1	0.8	0.5
Medication: Levothyroxine sodium	0.8	1.3	4.0	0.9	-1.0	0.1	-0.9	-1.3	-0.5	-2.0	-1.6	-0.6	-1.4	-1.0
Sitting height	1.3	8.9	20.7	2.1	-2.8	-1.8	3.4	1.0	0.5	3.2	3.4	4.5	3.6	3.8
Chronic bronchitis/emphysema (father)	0.3	0.3	1.2	0.5	0.1	0.4	-0.7	-0.0	0.3	-1.1	-0.8	0.1	-0.8	-0.5
High blood pressure (mother)	4.7	6.6	11.3	1.7	2.6	3.4	-3.2	2.7	3.0	-1.6	-2.5	-1.2	-2.4	-2.9
Body mass index (BMI)	0.2	0.8	2.5	1.6	0.9	0.8	-0.4	0.5	0.9	-0.7	-0.6	0.7	-1.2	-0.7
Impedance of leg (left)	1.0	4.8	12.9	0.9	-3.6	-2.3	2.3	-1.1	-1.5	1.3	1.8	1.5	2.7	3.4
Leg predicted mass (left)	0.2	1.3	6.1	1.2	-0.3	0.0	1.1	0.5	1.1	1.0	1.0	2.5	0.8	1.1
Trunk fat mass	0.4	1.9	6.9	2.6	-1.8	-0.8	1.3	-0.3	-0.1	0.1	0.7	2.1	0.4	1.6
Waist circumference	0.1	0.3	1.5	1.2	0.1	0.5	0.2	0.3	0.9	0.5	0.4	0.6	-0.1	0.2
Number of incorrect matches in round	0.5	0.8	2.1	-0.8	-0.3	-0.7	0.9	-0.2	-0.3	1.2	1.2	0.2	1.5	1.3
Past tobacco smoking	0.1	0.2	1.6	-1.2	-0.0	0.0	-0.1	-0.2	-0.1	-0.4	-0.3	-0.1	-0.6	0.1
Alcohol usually taken with meals	1.4	2.3	5.7	-0.8	1.5	1.2	-1.5	-0.6	0.2	-1.1	-1.7	-2.2	-2.0	-2.4
Nervous feelings	0.7	1.3	4.6	1.5	0.7	1.0	-0.7	2.1	1.5	-0.6	-0.6	1.4	-0.2	-0.1
Frequency of tenseness / restlessness in last 2 weeks	1.7	2.6	4.7	2.0	1.7	2.1	-1.6	2.1	2.2	-1.1	-1.4	0.7	-1.0	-1.0
Hearing difficulty/problems with background noise	1.0	1.7	2.9	1.3	-0.3	1.4	-1.6	0.9	0.8	-1.7	-1.7	-0.5	-1.7	-1.4
Hair/balding pattern: Pattern 2	0.3	0.3	0.9	0.2	0.3	0.9	-0.7	0.1	1.0	0.3	0.1	-1.0	-0.1	-0.6
Had menopause	0.3	0.4	1.4	0.2	0.9	0.8	-0.6	1.2	0.9	0.2	0.2	-0.3	-0.0	-0.3
Had other major operations	1.9	2.3	3.7	-1.8	-1.4	-1.9	1.7	-1.7	-1.9	1.5	1.7	-0.9	0.8	1.0
Forced vital capacity (FVC)	0.6	2.3	6.0	0.4	-2.4	-1.3	1.7	-0.9	-0.5	0.8	1.1	2.4	1.2	2.0
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.8	2.9	1.7	0.9	-0.4	0.2	0.7	-0.7	-1.3	-0.8	1.1	-0.7	0.5
Ever unenthusiastic/disinterested for a whole week	5.2	6.4	10.4	1.2	2.4	3.1	-3.2	2.8	2.2	-2.2	-2.6	-1.6	-2.7	-3.0
Qualifications: None of the above	0.9	1.9	4.2	0.7	2.0	0.7	0.3	1.8	1.6	2.0	1.5	0.4	1.8	0.5
Financial difficulties in last 2 years	0.8	1.1	3.6	1.6	1.2	0.8	0.1	1.9	1.3	-0.2	0.2	1.4	-0.3	0.3
Mouth/teeth dental problems	0.7	1.1	4.7	0.4	-2.2	-0.8	0.3	-1.3	-1.3	-1.3	-0.5	0.6	-0.9	0.5
Heart attack	0.2	0.2	0.9	0.2	0.9	0.1	0.2	0.2	0.3	0.1	0.1	0.7	0.5	0.6
Allergy	0.5	1.1	3.3	-1.3	1.8	0.2	-0.2	0.4	0.2	1.4	0.6	-1.8	0.4	-1.0
Pain all over the body in last month	0.6	0.7	1.7	-0.3	0.3	1.2	-1.3	0.5	0.9	-0.8	-1.1	-0.7	-0.5	-0.7
Diabetes (self-reported)	0.6	1.0	5.2	-1.2	-1.5	-0.1	-0.2	-2.3	-0.6	-0.5	-0.2	-0.8	-0.6	-0.6
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	3.4	0.4	-1.1	-0.1	-0.6	-0.5	-0.8	-1.8	-1.5	0.2	-1.2	-0.3
Medication: Ramipril	0.5	0.6	3.6	-0.5	-0.2	1.3	-0.8	0.3	1.9	0.2	-0.1	0.2	0.4	-0.3
Medication: Simvastatin	2.8	4.2	8.6	0.1	2.4	2.9	-2.5	2.0	2.6	-1.2	-1.6	-1.3	-1.8	-2.4
Fluid intelligence score	1.3	2.7	5.9	-0.5	1.4	1.1	-1.8	-0.4	0.1	-2.2	-2.3	-1.3	-2.4	-2.2
Illnesses of siblings	0.5	0.7	3.0	-1.7	0.8	0.1	0.0	0.5	0.4	1.2	0.6	-1.0	0.8	0.0
Neuroticism score	1.2	2.4	6.8	2.4	0.5	1.7	-0.9	2.4	2.6	-0.4	-0.5	2.0	-0.0	0.2
Weight	0.5	2.5	9.0	2.0	-1.4	-0.7	1.8	0.1	0.6	1.2	1.4	3.0	1.2	2.0
Impedance of arm (right)	0.5	2.3	9.9	3.1	-2.3	-0.2	-0.3	0.3	-0.6	-2.3	-1.3	1.2	-0.7	0.9
Arm fat percentage (right)	0.5	2.0	9.4	3.1	-0.1	0.9	-0.8	0.5	0.6	-1.9	-1.5	0.8	-1.8	-0.7
Trunk fat-free mass	0.8	4.4	10.9	-0.6	-0.9	-1.1	2.5	0.0	0.7	3.3	2.8	2.6	2.9	2.4
Hip circumference	0.9	3.8	11.0	1.6	-2.5	-0.8	2.1	-0.1	0.7	1.5	1.8	3.3	1.9	2.7
Time employed in main current job	0.2	0.2	0.4	-0.7	0.1	0.2	-0.6	0.4	0.2	-0.0	-0.5	-0.6	-0.3	-0.7
Alcohol intake versus 10 years previously	0.2	0.3	1.1	0.3	0.7	0.7	-0.3	0.6	1.0	0.5	0.1	-0.3	0.0	-0.6
Father’s age at death	0.7	1.0	2.6	0.0	-0.1	-1.6	1.3	-0.4	-1.4	0.2	0.5	1.4	0.4	1.2
Worrier / anxious feelings	0.4	0.8	3.3	0.6	0.5	1.4	-1.2	1.0	1.8	-0.0	-0.4	-0.7	0.2	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.4	5.9	1.4	-0.1	0.5	0.3	1.6	1.6	0.1	0.4	2.4	0.7	1.3
Falls in the last year	0.1	0.2	0.4	-0.3	-0.6	0.2	-0.2	-0.5	-0.0	-0.3	-0.5	-0.2	-0.5	-0.6
Hair/balding pattern: Pattern 3	0.3	0.4	1.8	-0.1	1.3	0.3	-0.5	0.0	0.0	-0.9	-0.9	0.4	-0.7	-0.6
Number of live births	1.5	2.1	3.6	-1.0	-1.1	-1.9	1.6	-1.1	-1.8	1.4	1.6	-0.8	1.5	1.9
Forced expiratory volume in 1-second (FEV1)	0.5	1.8	4.6	0.3	-2.1	-1.1	1.6	-0.9	-0.4	1.0	1.1	2.0	1.0	1.7
Pulse rate	0.9	1.5	4.0	-0.3	-1.9	-1.5	1.5	-2.0	-1.5	0.7	0.8	0.6	0.5	0.7
Happiness	0.4	0.5	4.1	-2.0	0.6	-0.0	0.1	0.0	0.1	0.4	0.4	-0.3	0.6	0.2
Noisy workplace	0.4	0.4	1.4	-1.1	-0.0	0.2	0.2	-0.4	0.6	1.2	1.0	-0.6	0.5	-0.2
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.6	-1.1	0.2	0.3	-0.8	-0.5	-0.2	-1.2	-1.3	-0.6	-1.2	-1.0
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.8	4.4	0.2	1.8	1.9	-1.3	1.9	2.1	-0.3	-0.8	0.2	-0.7	-1.4
Mouth/teeth dental problems: Dentures	1.0	1.6	6.6	-0.2	2.6	1.3	-0.8	1.5	1.5	1.1	0.1	-1.3	0.6	-1.1
Asthma	0.7	1.5	4.9	1.3	-0.1	1.2	-1.3	0.6	0.9	-2.2	-1.7	0.5	-1.4	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.7	0.3	0.1	0.8	-0.7	-0.5	0.8	-0.1	-0.2	-0.6	-0.1	-0.7
Medication: Cholesterol lowering	1.8	2.8	5.9	-0.7	1.9	2.4	-2.1	0.9	1.9	-1.0	-1.5	-1.7	-1.3	-1.9
Depression (self-reported)	0.5	0.6	1.5	1.2	-1.2	-0.5	0.9	0.2	-0.2	0.4	0.6	0.9	0.1	1.0
Medication: Lansoprazole	2.8	3.2	7.8	1.8	-0.1	1.2	-1.9	-0.5	-0.0	-2.8	-2.6	-0.3	-2.8	-2.1
Prospective memory result	2.0	2.4	6.7	-0.5	-1.2	-0.5	1.4	0.4	0.6	2.5	2.1	1.3	2.6	1.7
Lung cancer (father)	0.3	0.4	1.1	0.3	-1.0	-0.4	0.4	-0.8	-0.0	-0.1	0.6	0.8	0.4	1.1
Illnesses of mother	1.3	1.6	2.8	-1.0	-0.8	-1.2	1.7	-0.7	-0.5	1.4	1.4	1.4	1.6	1.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	4.8	0.4	-2.2	-0.7	0.9	-1.0	-0.5	0.2	0.3	1.4	0.2	1.0
Pulse wave Arterial Stiffness index	1.0	1.1	4.0	1.3	-0.0	0.1	0.6	2.0	0.8	1.0	1.2	0.8	1.1	1.2
Impedance of arm (left)	0.5	2.1	8.1	2.8	-2.3	-0.5	-0.2	-0.2	-1.0	-2.2	-1.2	1.0	-0.7	0.9
Arm fat mass (right)	0.3	1.2	7.3	2.7	-0.3	0.4	0.1	0.4	0.7	-0.8	-0.5	1.8	-0.8	0.2
Trunk predicted mass	0.8	4.3	10.5	-0.5	-0.9	-1.1	2.5	0.0	0.7	3.2	2.8	2.6	2.8	2.4
Standing height	1.7	16.5	34.2	1.1	-4.7	-3.3	4.9	-0.8	-0.6	4.1	4.5	5.0	5.2	5.8
Length of working week for main job	0.2	0.2	1.2	-0.7	1.1	0.1	-0.3	0.7	0.1	-0.3	-0.3	0.2	-0.2	-0.3
Exposure to tobacco smoke at home	3.0	3.3	7.6	-0.5	-1.6	-2.6	2.3	-2.8	-2.6	1.2	1.7	0.3	1.1	1.5
Breastfed as a baby	1.2	1.5	2.5	-1.2	-1.1	-1.4	1.4	-0.3	-1.1	1.6	1.5	0.0	1.6	1.3
Tense / ‘highly strung’	1.0	1.6	4.5	0.7	-1.4	-0.4	1.0	1.3	0.3	0.8	1.0	2.1	1.4	2.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.4	1.0	-0.0	1.0	-0.7	1.2	0.9	-1.1	-0.9	0.8	-1.1	-0.3
Hair/balding pattern: Pattern 4	2.2	5.4	12.9	0.3	2.1	2.6	-3.0	0.1	1.4	-2.2	-2.8	-1.9	-2.8	-3.6
Birth weight of first child	0.6	1.1	3.2	0.2	1.2	0.4	-1.0	0.4	-0.6	-1.8	-1.6	-0.3	-1.6	-0.8
Peak expiratory flow (PEF)	0.3	0.8	3.5	0.9	-1.9	-0.4	0.7	-0.7	0.1	0.3	0.3	1.5	0.2	0.7
Pulse wave reflection index	2.4	3.0	14.0	1.9	2.1	1.7	-1.4	3.7	1.7	-0.8	-0.9	-0.0	-0.9	-0.8
Ever highly irritable/argumentative for 2 days	1.6	2.0	4.2	1.4	1.5	1.1	-1.4	-0.1	0.5	-1.7	-1.8	-0.3	-1.9	-2.1
Loud music exposure frequency	4.0	4.4	9.6	1.5	1.6	2.1	-2.3	0.3	1.3	-2.7	-2.7	-0.2	-3.1	-2.7
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	2.3	-0.5	0.1	0.0	-0.7	-0.2	-0.5	-1.5	-1.4	-0.1	-1.1	-0.4
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.2	-1.1	0.0	-0.7	0.7	0.2	-0.7	0.4	0.6	-0.2	0.6	0.8
Blood clot in the leg (DVT)	0.4	0.6	2.1	-0.8	1.0	0.8	-0.1	0.5	1.5	1.1	0.4	-0.3	0.5	-0.1
Medication: Paracetamol	0.2	0.3	1.4	0.9	-1.2	0.2	-0.2	-0.0	-0.0	-0.4	-0.2	-0.4	-0.7	-0.4
Headache pain in last month	0.2	0.3	0.5	0.7	-0.2	0.6	-0.5	-0.2	0.7	-0.4	-0.4	-0.5	-0.6	-0.7
Medication for cholesterol, blood pressure or diabetes	1.5	2.5	6.5	-0.9	-1.2	-2.6	2.0	-1.0	-2.4	0.9	1.4	0.7	1.1	1.6
Glaucoma (self-reported)	0.5	0.6	1.7	0.3	0.8	1.3	-1.0	0.8	1.3	-0.3	-0.7	-0.6	-0.2	-0.5
Gout (self-reported)	1.1	1.5	4.2	0.4	-2.1	-1.3	1.4	-0.5	-1.0	0.1	0.7	1.7	0.8	1.6
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	2.1	0.1	-1.3	0.1	-0.8	-1.4	-0.4	-1.3	-1.1	-1.1	-1.1	-0.8
Medication: Amlodipine	1.3	1.8	5.5	2.3	-0.5	1.1	-1.3	0.2	0.6	-2.1	-1.8	0.4	-1.4	-1.1
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.2	-0.2	-0.3	-0.2	0.0	-0.3	-0.5	-0.4	-0.1	0.1	-0.4	-0.2
Birth weight	0.1	0.1	0.9	0.3	0.2	-0.6	0.4	0.0	-0.9	0.2	0.3	-0.2	-0.1	0.1
Chronic bronchitis/emphysema (mother)	0.1	0.2	0.5	-0.7	0.4	-0.2	0.1	-0.1	-0.6	0.2	-0.2	-0.6	0.1	-0.5
High blood pressure (siblings)	0.7	1.0	3.7	1.9	-0.8	0.0	-0.5	-0.1	-0.4	-1.7	-1.1	1.1	-1.1	-0.3
Forced vital capacity (FVC), Best measure	0.5	1.7	7.0	0.1	-2.7	-1.1	1.4	-1.2	-0.7	0.7	0.8	1.5	0.9	1.5
Body fat percentage	0.3	1.2	8.7	3.0	-1.1	-0.1	0.3	-0.2	0.0	-0.9	-0.3	1.3	-0.6	0.6
Leg fat percentage (right)	0.2	0.9	6.5	2.6	-0.8	0.0	0.2	-0.1	0.1	-0.8	-0.4	1.1	-0.7	0.3
Arm fat-free mass (right)	0.8	4.3	10.8	-0.5	-0.9	-1.3	2.6	-0.5	0.4	3.3	2.9	2.3	2.7	2.3
Exposure to tobacco smoke outside home	0.8	1.0	2.5	0.7	-0.6	-1.3	1.4	-0.4	-1.1	0.3	0.8	1.6	0.5	1.4
Comparative body size at age 10	0.4	1.1	3.3	0.8	1.7	0.8	-0.8	0.7	0.3	-1.2	-1.0	0.1	-1.8	-1.0
Number of full brothers	0.4	0.5	1.4	-0.8	-0.3	-0.0	-0.4	-0.7	-0.5	-0.8	-0.8	-1.1	-1.2	-0.7
Worry too long after embarrassment	3.5	5.9	12.4	1.9	2.5	3.4	-2.8	3.2	3.5	-1.6	-2.0	-0.2	-1.7	-1.9
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.6	2.6	1.5	0.9	1.4	-1.3	1.6	1.1	-1.6	-1.5	0.3	-1.3	-0.8
Wheeze or whistling in the chest in last year	1.7	3.1	5.8	1.4	1.3	2.0	-2.2	1.2	1.0	-2.4	-2.4	-0.8	-2.0	-1.6
Number of children fathered	1.3	1.5	3.1	-0.4	-1.7	-0.9	1.5	-0.8	-0.3	0.9	1.3	1.4	1.3	1.8
Reason for reducing amount of alcohol drunk: Health precaution	1.8	2.1	5.8	1.3	-2.0	-1.6	1.5	0.1	-1.1	0.2	0.8	2.4	1.1	2.0
Age at first live birth	0.9	1.6	3.4	-0.9	-1.5	-1.0	1.4	-0.8	-0.1	0.8	1.1	1.9	1.4	1.6
Pulse wave peak to peak time	0.7	0.8	4.1	-1.1	-0.2	-0.3	-0.3	-2.0	-0.8	-0.8	-0.9	-0.5	-0.7	-0.8
Health satisfaction	3.3	4.3	9.3	1.0	3.1	2.3	-2.6	1.9	1.5	-2.0	-2.3	-1.2	-1.9	-2.1
Shortness of breath walking on level ground	0.1	0.1	0.4	0.2	0.7	0.3	0.0	0.3	0.5	-0.4	-0.1	0.5	-0.3	0.1
Qualifications: College or University degree	0.2	0.6	1.6	-1.3	-0.1	0.5	-0.8	-0.3	-0.1	-0.6	-0.8	-0.8	-1.0	-1.2
Eye problems/disorders: None of the above	0.2	0.2	1.1	1.0	-0.2	0.2	-0.3	0.9	0.3	-0.2	-0.3	0.5	0.0	-0.3
Mouth/teeth dental problems: Loose teeth	1.5	1.8	6.3	-1.4	-1.2	-1.2	0.1	-2.5	-2.1	-0.7	-0.4	-1.7	-0.7	-0.4
Emphysema/chronic bronchitis	0.3	0.4	1.3	0.3	0.7	0.9	-0.4	1.0	1.1	0.5	0.0	0.1	0.4	-0.1
Medication for pain relief, constipation, heartburn	0.9	1.6	3.6	0.3	-1.0	-1.9	1.5	-0.8	-1.9	-0.2	0.3	1.9	0.3	1.5
Neck or shoulder pain in last month	0.2	0.3	1.2	0.9	-0.6	0.2	-0.0	-1.1	0.5	0.3	0.2	0.0	-0.0	-0.4
Medication: Blood pressure	0.6	1.0	2.8	1.7	-0.4	1.1	-1.0	-0.6	0.7	-1.3	-1.2	-0.0	-1.0	-0.8
Angina (self-reported)	1.6	2.2	5.1	0.8	2.3	2.0	-1.6	1.6	2.2	0.3	-0.5	-1.3	-0.0	-1.4
Migraine (self-reported)	0.1	0.1	1.1	1.0	-0.1	0.2	-0.1	0.3	0.2	-0.1	-0.1	0.4	-0.2	-0.2
Medication: Ibuprofen	0.3	0.4	0.8	0.6	-0.1	0.6	-0.8	-0.9	0.4	-0.6	-0.5	-0.5	-0.5	-0.8
Medication: Allopurinol	2.2	2.9	6.7	-0.7	-2.6	-1.8	2.2	-1.4	-1.1	1.4	1.8	1.4	1.7	1.8
Medication: Omeprazole	0.2	0.2	0.5	0.2	0.5	0.6	-0.5	-0.0	0.6	0.1	-0.3	-0.7	-0.1	-0.3
Medication: Seretide 50 evohaler	1.0	1.2	3.1	1.4	1.2	1.3	-0.9	1.6	1.8	-0.3	-0.7	0.8	-0.1	-0.4
Mean time to correctly identify matches	0.7	1.4	3.5	-1.0	-0.1	-0.6	1.1	0.3	0.1	1.9	1.7	-0.1	1.9	1.7
Heart disease (mother)	0.7	0.9	1.7	1.0	1.2	1.3	-1.0	1.0	1.3	-0.2	-0.3	-0.2	-0.5	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	3.2	-0.3	0.8	-0.8	0.0	-0.5	-1.6	-1.5	-0.7	-0.5	-1.8	-0.5
Whole body fat mass	0.3	1.3	6.4	2.5	-1.3	-0.5	1.0	-0.4	0.0	-0.1	0.4	1.8	-0.1	1.1
Leg fat mass (right)	0.3	1.3	6.9	2.6	-1.1	-0.3	0.9	-0.2	0.3	-0.1	0.3	2.0	-0.1	0.9
Arm predicted mass (right)	0.8	3.9	9.5	-0.3	-0.9	-1.3	2.5	-0.5	0.4	3.1	2.8	2.4	2.5	2.2
Pulse rate, automated reading	1.8	5.8	13.0	-1.0	-3.5	-3.1	2.8	-3.6	-2.9	1.6	2.1	0.6	1.1	1.8
Alcohol intake frequency.	0.3	0.8	2.8	0.8	1.1	0.7	0.2	0.9	1.7	0.6	0.5	1.2	0.7	0.4
Comparative height size at age 10	0.5	2.7	5.0	0.7	-2.2	-1.0	1.8	-0.4	0.4	1.9	1.8	1.8	2.2	2.0
Number of full sisters	0.4	0.5	2.3	1.5	-1.0	0.0	0.1	-0.5	-0.0	-0.7	-0.5	1.1	-0.4	0.1
Suffer from ‘nerves’	1.7	2.6	6.0	2.2	1.0	1.9	-1.3	2.5	2.4	-1.0	-1.4	1.8	-0.5	-0.4
Overall health rating	0.3	0.8	4.0	2.0	0.3	0.9	-0.7	0.8	1.2	-0.4	-0.5	0.5	-0.3	-0.2
Chest pain or discomfort	0.8	1.2	2.9	0.4	0.9	1.7	-1.6	1.0	1.5	-0.7	-1.3	-0.5	-0.2	-0.9
Had major operations	0.2	0.2	0.9	-0.5	-0.4	0.2	-0.2	-0.9	-0.1	-0.0	-0.1	-0.7	-0.6	-0.7
Age at last live birth	1.5	2.1	4.1	-1.3	-2.0	-1.3	1.7	-0.9	-0.6	1.3	1.5	1.3	1.6	2.0
Family relationship satisfaction	0.8	0.9	1.7	-1.1	-0.4	0.3	-0.9	-0.4	-0.8	-1.2	-1.1	-1.3	-1.2	-1.2
Leg pain on walking	0.7	0.9	1.6	0.1	0.8	0.3	0.5	1.1	1.2	1.0	1.0	1.2	1.1	1.0
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	3.3	1.8	-0.6	-0.7	0.4	-0.7	-0.7	-1.1	-0.4	1.1	-0.6	0.8
Commuting to job workplace: Car/motor vehicle	0.3	0.3	2.2	1.5	-0.2	0.2	-0.2	0.5	0.5	0.1	-0.0	0.6	0.5	0.3
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	3.4	-1.1	-1.8	-1.4	0.7	-1.3	-1.8	0.1	0.4	-0.5	0.6	1.0
Medication: Aspirin	1.3	1.7	3.3	0.5	1.2	1.8	-1.7	0.9	1.8	-0.7	-1.1	-0.8	-0.8	-1.8
Supplements: Vitamin C	0.2	0.3	0.6	0.3	0.7	0.4	-0.2	0.8	0.5	-0.4	-0.5	0.7	-0.2	-0.5
Knee pain experienced in last month	1.2	1.8	2.6	1.3	-1.5	-0.9	1.6	-0.7	0.2	1.5	1.6	1.6	1.6	1.5
Hypertension (Self-reported)	2.2	6.0	18.6	4.3	0.1	2.8	-2.6	2.0	2.2	-2.7	-2.6	0.2	-2.4	-2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.8	2.1	4.2	1.1	0.4	2.0	-1.9	1.7	1.7	-0.4	-1.5	-1.3	-0.8	-1.7
Illnesses of father: Heart disease	1.6	2.2	3.2	1.4	1.7	1.8	-1.6	1.8	1.6	-1.3	-1.5	0.5	-1.1	-1.7
Illnesses of siblings: Diabetes	0.1	0.1	0.4	0.6	-0.5	0.0	-0.0	-0.4	0.1	-0.0	0.1	0.2	-0.1	-0.2
Smoking status: Previous	0.1	0.2	1.2	1.1	-0.4	-0.2	0.1	-0.3	0.0	0.3	0.3	0.3	0.6	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.0	0.3	-1.0	0.0	0.3	0.6	0.7	0.7	0.3	0.7	1.0	0.6
Whole body fat-free mass	0.6	3.3	7.3	0.0	-0.8	-0.9	2.2	0.1	0.8	2.7	2.4	2.7	2.2	2.1
Leg fat-free mass (right)	0.3	1.7	7.0	0.9	-0.4	-0.3	1.5	0.4	1.0	1.4	1.4	2.6	1.1	1.4
Arm fat percentage (left)	0.4	1.7	7.7	2.8	-0.1	0.8	-0.8	0.2	0.4	-1.9	-1.5	0.6	-1.9	-0.8
Average weekly red wine intake	0.9	1.3	4.4	1.5	-0.0	0.6	-0.9	0.6	0.1	-2.1	-1.7	0.8	-1.4	-0.3
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.9	-0.1	0.5	-0.6	0.3	0.1	-0.9	-0.1	-0.1	0.1	0.0	0.2
Mood swings	1.3	2.4	6.8	2.2	1.0	1.0	0.1	2.6	2.1	0.4	0.3	2.6	0.7	1.1
Loneliness, isolation	1.3	1.9	4.3	2.1	1.1	1.2	-0.7	1.7	1.4	-1.5	-1.2	1.8	-0.8	0.0
Long-standing illness, disability or infirmity	0.7	1.0	4.8	0.1	0.9	1.4	-0.5	1.5	2.2	0.7	0.5	0.4	0.5	-0.2
Ever had bowel cancer screening	0.6	0.7	1.6	0.2	0.5	-0.5	1.0	0.5	-0.1	1.1	1.1	0.5	1.3	1.1
Diabetes diagnosed by doctor	0.8	1.2	4.7	-1.0	-1.7	0.1	-0.5	-2.2	-0.7	-1.0	-0.6	-1.1	-1.0	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	2.7	-1.5	0.3	0.3	-0.6	0.2	-0.3	-0.1	-0.4	-1.7	-0.5	-1.3
Friendships satisfaction	0.9	1.1	1.8	-1.2	1.0	0.2	-1.0	0.6	-0.7	-1.4	-1.2	-0.9	-1.3	-1.2
Qualifications: nursing, teaching	0.8	1.2	2.7	-0.9	-0.7	-0.6	-0.3	-1.5	-1.6	-1.7	-1.2	-0.6	-1.4	-0.6
Commuting to job workplace: Walk	0.2	0.2	0.7	0.8	-0.3	0.2	-0.1	0.1	0.2	-0.5	-0.3	0.8	-0.3	-0.2
Eye problems/disorders: Cataract	0.2	0.2	0.7	-0.6	0.8	0.3	-0.2	0.0	0.2	-0.5	-0.3	-0.1	-0.8	-0.3
Mouth/teeth dental problems: Mouth ulcers	1.1	1.8	6.1	0.4	2.5	1.6	-0.7	1.6	2.4	0.9	0.3	0.5	0.3	-1.0
Medication for cholesterol	1.8	2.7	4.1	-1.8	-1.3	-1.8	1.8	-1.8	-1.2	1.7	1.7	0.5	1.9	2.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.3	2.8	4.8	0.4	2.2	2.1	-1.9	1.8	1.5	-1.6	-1.9	-0.4	-1.5	-1.8
Back pain experienced in last month	0.3	0.4	1.6	0.0	0.4	0.2	0.2	-0.1	0.7	1.2	0.9	-0.3	1.0	-0.0
Mineral and other dietary supplements	0.9	1.2	3.3	-0.9	1.8	1.0	-1.3	0.6	0.4	-0.9	-1.2	-1.5	-1.0	-1.1
Breast cancer (self-reported)	0.7	0.9	2.6	1.6	-1.4	-0.8	0.8	-0.7	-0.9	-0.3	0.0	0.9	-0.1	1.2
Asthma (self-reported)	0.5	1.0	4.1	0.9	-0.4	0.9	-1.0	0.1	0.6	-2.0	-1.5	0.4	-1.3	-0.1
Osteoporosis (self-reported)	0.5	0.6	1.9	-0.5	0.3	0.6	-0.8	0.3	0.0	-0.7	-0.7	-1.0	-1.2	-1.4
Osteoarthritis (self-reported)	0.2	0.3	0.7	-0.4	-0.3	-0.1	0.4	-0.1	0.4	0.8	0.7	0.4	0.8	0.8
Medication: Aspirin	1.6	2.1	4.1	0.7	1.2	2.0	-1.9	1.1	1.9	-1.0	-1.4	-0.9	-1.0	-1.9
Medication: Gliclazide	0.1	0.1	0.8	-0.9	0.4	0.1	-0.2	-0.2	-0.0	-0.2	-0.1	0.1	-0.4	-0.5
Illnesses of father: None of the above (group 1)	2.3	2.9	3.9	-1.8	-1.5	-2.0	1.8	-1.5	-2.0	1.9	1.9	-0.9	1.6	1.4
Smoking status: Current	0.1	0.1	0.4	-0.3	0.3	-0.2	0.1	-0.2	-0.4	0.4	0.2	-0.6	0.0	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.7	-0.4	-0.7	-0.3	0.0	-0.9	-0.9	-0.8	-0.6	-0.1	-1.3	-0.4
Whole body water mass	0.6	3.3	7.5	-0.1	-0.8	-0.9	2.3	0.0	0.8	2.7	2.4	2.6	2.3	2.1
Leg predicted mass (right)	0.3	1.8	7.3	0.9	-0.4	-0.3	1.5	0.5	1.0	1.5	1.4	2.7	1.2	1.5
Arm fat mass (left)	0.2	0.9	5.7	2.4	-0.5	0.1	0.3	0.0	0.4	-0.5	-0.2	1.6	-0.6	0.3
Number of self-reported non-cancer illnesses	0.9	1.6	3.6	1.2	0.6	1.9	-1.6	0.6	1.6	-1.1	-1.4	-0.7	-1.1	-1.4
Average weekly champagne plus white wine intake	0.3	0.4	1.8	-1.4	0.8	-0.2	-0.1	0.1	-0.3	0.3	-0.0	-1.0	0.1	-0.1
Miserableness	0.9	1.5	4.4	1.3	0.5	0.7	0.4	1.7	1.9	1.0	0.9	2.1	0.7	1.1
Guilty feelings	1.1	1.6	3.7	0.8	0.0	1.2	-1.6	0.3	0.6	-1.9	-1.7	-0.6	-1.9	-1.6
Wears glasses or contact lenses	1.8	2.1	6.8	0.9	1.7	2.1	-1.5	2.6	2.1	0.1	-0.5	-0.3	-0.0	-1.1
Ever taken oral contraceptive pill	0.2	0.3	1.2	0.7	0.4	0.3	0.1	0.1	0.9	-0.0	0.0	1.1	0.3	0.1
Hearing aid user	1.0	1.1	2.4	1.4	1.6	0.3	-0.8	1.4	-0.2	-1.2	-1.2	0.5	-1.1	-0.8
Mother’s age at death	3.4	4.3	7.6	-0.8	-1.6	-2.4	2.8	-1.2	-1.4	2.4	2.6	1.5	2.4	2.6
Financial situation satisfaction	1.4	1.7	3.8	-0.4	1.9	1.6	-1.5	1.8	1.2	-1.1	-1.2	-0.7	-1.1	-1.1
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.8	0.5	-0.3	-0.4	0.5	0.3	-0.2	0.9	0.9	-0.2	0.3	0.5
Commuting to job workplace: Public transport	1.1	1.4	3.2	0.1	1.8	1.3	-1.1	1.1	1.2	-0.7	-1.2	-0.3	-1.2	-1.7
Eye problems/disorders: Glaucoma	0.2	0.2	0.7	0.4	0.0	0.5	-0.2	0.8	0.8	0.1	-0.2	0.3	0.4	0.4
Medication: Blood pressure	2.3	4.4	12.8	3.6	0.7	2.5	-2.2	2.2	2.0	-1.7	-1.8	-0.2	-2.0	-2.3
Pain type(s) experienced in last month: Hip pain	0.2	0.3	1.1	1.1	0.6	0.6	-0.2	0.3	0.9	0.1	-0.1	0.3	-0.2	-0.5
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.9	1.0	-0.8	0.2	-0.1	-0.2	0.4	0.0	0.2	0.3	-0.0	-0.2
High cholesterol (Self-reported)	2.0	3.6	8.4	-0.1	0.9	2.3	-2.5	0.5	1.4	-1.7	-2.1	-2.1	-2.3	-2.9
Medication: Bendroflumethiazide	2.5	3.7	8.9	3.0	0.4	1.6	-2.1	0.2	0.4	-2.5	-2.5	-0.7	-2.5	-2.4
Medication: Paracetamol	0.6	1.0	2.2	1.5	-0.8	1.0	-1.1	0.5	0.6	-1.2	-1.0	-0.4	-1.2	-1.0
Medication: Lisinopril	1.1	1.4	2.4	0.5	1.0	1.5	-1.5	0.6	0.9	-1.2	-1.1	-1.2	-1.5	-1.5
Medication: Atorvastatin	0.7	0.9	2.6	-0.3	-0.2	0.6	-1.1	-0.4	-0.3	-0.9	-1.1	-1.6	-1.1	-1.5
Illnesses of father: High blood pressure	4.6	5.7	14.6	3.8	1.7	2.7	-2.2	2.6	2.7	-2.2	-2.3	1.7	-1.9	-1.3
Alcohol drinker status: Never	2.5	3.0	8.1	1.0	1.8	2.6	-1.9	2.2	2.8	-0.6	-1.4	0.3	-0.9	-1.4
Ever smoked	0.2	0.3	0.9	1.0	-0.3	-0.3	0.5	0.0	-0.2	0.8	0.6	0.3	0.9	0.3
Basal metabolic rate	0.6	3.2	8.4	0.6	-1.0	-0.9	2.2	0.1	0.7	2.3	2.2	2.9	2.0	2.2
Leg fat percentage (left)	0.3	1.0	5.3	2.3	-0.9	-0.4	0.8	-0.1	0.0	-0.1	0.3	1.6	0.0	1.1
Arm fat-free mass (left)	0.9	4.7	9.9	-0.2	-1.0	-1.4	2.8	-0.4	0.4	3.1	2.9	2.8	2.7	2.7
Number of operations (self-reported)	0.1	0.1	0.6	-0.2	0.2	-0.2	0.4	-0.0	-0.2	0.8	0.5	-0.4	0.3	-0.0
Average weekly beer plus cider intake	1.3	1.9	3.4	-0.4	-1.7	-1.8	1.8	-0.8	-1.4	1.3	1.6	0.8	1.4	1.5
Irritability	0.3	0.5	1.2	1.1	-0.3	0.1	0.3	0.4	0.7	0.6	0.5	1.0	0.8	0.7
Risk taking	0.3	0.5	1.0	0.1	0.5	0.8	-0.8	0.7	0.2	-0.6	-0.8	-1.0	-0.6	-0.9
Ever had prostate specific antigen (PSA) test	1.5	1.7	3.4	0.9	0.4	1.2	-1.6	-0.6	0.5	-1.7	-1.7	-0.7	-1.8	-1.8
Fractured/broken bones in last 5 years	0.3	0.4	1.1	0.1	0.4	0.8	-0.8	0.0	1.1	0.3	-0.1	-0.8	-0.1	-1.0
Age started oral contraceptive pill	1.7	2.1	4.2	-1.2	-1.5	-2.0	1.8	-1.4	-2.0	0.8	1.3	0.3	1.2	1.5
Diastolic blood pressure, automated reading	1.2	3.8	17.4	4.2	-0.7	1.7	-1.4	2.9	2.1	-1.2	-1.4	1.5	-0.6	-0.1
Ever depressed for a whole week	4.4	5.5	8.2	0.9	2.8	2.9	-2.8	2.2	1.9	-2.1	-2.3	-1.4	-2.7	-2.8
Unable to work because of sickness or disability	0.6	0.8	2.4	-1.3	-0.3	0.1	0.1	0.1	0.3	1.4	1.1	-1.5	1.0	0.3
Commuting to job workplace: Cycle	0.8	0.9	1.8	-0.4	-0.7	-1.4	1.3	-0.7	-1.1	0.9	1.1	0.3	1.0	1.0
Myopia	3.0	4.4	7.0	2.0	1.8	2.6	-2.5	1.6	1.9	-2.1	-2.5	-0.8	-2.2	-2.2
Vascular/heart problems diagnosed by doctor	2.2	6.1	13.8	-3.7	-1.1	-3.3	2.6	-2.9	-3.1	1.8	2.1	-0.1	1.9	2.3
Cholesterol lowering medication	2.1	3.0	6.3	1.0	1.1	1.9	-2.1	1.2	0.9	-1.9	-2.1	-0.9	-2.4	-2.5
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.7	0.4	0.8	0.8	-0.8	0.1	0.7	-0.4	-0.6	-0.7	-0.5	-0.4
Pain experienced in last month	0.6	0.9	4.6	-2.1	-0.3	-1.0	0.2	-0.3	-1.8	-0.6	-0.2	-0.6	-0.5	0.2
Supplements: Calcium	0.6	0.7	1.4	1.2	-1.0	-1.1	1.0	-0.7	-1.1	0.4	0.6	0.2	0.5	0.8
Basal cell carcinoma (self-reported)	0.3	0.3	1.0	0.3	-0.2	-0.8	0.4	-0.6	-1.0	-0.8	-0.0	0.3	-0.5	0.6
Heart attack/myocardial infarction (self-reported)	0.2	0.3	1.0	0.2	1.0	0.1	0.3	0.2	0.5	0.3	0.2	0.8	0.6	0.7
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	2.7	-0.8	1.0	1.0	-0.4	0.6	1.6	0.9	0.2	-0.4	0.3	-0.3
Heart disease (siblings)	0.5	0.6	1.5	1.2	-0.4	-0.3	-0.1	-1.2	-0.8	-0.9	-0.5	-0.3	-1.0	-0.4
Alcohol drinker status: Previous	0.7	0.8	3.5	1.2	0.0	-0.2	0.7	0.7	0.3	-0.1	0.3	1.9	1.1	1.3
Pack years of smoking	1.0	1.5	3.5	-0.9	-0.6	-1.2	1.4	-0.8	-0.9	1.9	1.7	-0.5	1.6	1.2
Impedance of whole body	0.6	2.9	10.2	2.3	-3.2	-1.6	1.2	-0.7	-1.5	-0.7	0.3	1.5	1.0	2.4
Leg fat mass (left)	0.4	1.4	5.7	2.4	-1.0	-0.4	1.2	-0.1	0.3	0.3	0.7	2.2	0.3	1.2
Arm predicted mass (left)	0.9	4.5	9.6	-0.2	-1.2	-1.4	2.7	-0.4	0.3	3.1	2.9	2.6	2.7	2.6