TWAS hub - PLEKHG3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.2460	0.0570	2.0e-09	0.123	NA	0.080	NA	0.089	1.7e-09	NA	1.4e-06	NA	3.6e-07
2	GTEx	Esophagus Muscularis	0.2110	0.0690	1.3e-04	0.029	NA	0.032	NA	0.028	7.0e-03	NA	4.5e-03	NA	7.4e-03
3	GTEx	Lung	0.1554	0.0478	4.8e-05	0.035	NA	0.046	NA	0.086	9.8e-04	NA	2.0e-04	NA	3.8e-07
4	YFS	Blood	0.0781	0.0172	0.0e+00	0.090	0.069	0.086	0.088	0.091	5.0e-28	1.1e-21	1.0e-26	2e-27	4.4e-28
5	TCGA	Breast Invasive Carcinoma	0.0329	0.0151	3.7e-04	0.018	0.015	0.022	NA	0.023	9.2e-05	3.2e-04	2.2e-05	NA	1.1e-05
6	TCGA	Pancreatic Adenocarcinoma	0.1320	0.0560	1.4e-03	0.118	0.099	0.086	NA	0.103	1.2e-05	6.2e-05	1.9e-04	NA	4.5e-05
7	TCGA	Prostate Adenocarcinoma	0.0548	0.0208	1.0e-05	0.053	0.048	0.046	NA	0.055	3.3e-06	9.3e-06	1.3e-05	NA	1.8e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Taking other prescription medications	6.4	9.9	13.2	-0.7	2.7	3.6	3.6	3.4	3.6	3.3
Diabetes (father)	6.1	7.6	14.2	0.4	3.8	3.1	2.4	2.6	3.0	2.8
Medication: Gliclazide	4.4	5.0	12.2	-0.8	0.5	2.6	3.5	2.8	2.3	1.2
Alcohol drinker status: Never	4.2	5.1	8.9	0.1	3.0	1.6	2.3	2.5	2.7	2.3
Supplements: Calcium	4.0	4.4	7.4	-1.2	1.4	2.5	2.7	2.5	2.3	1.5
Illnesses of siblings: Diabetes	3.8	4.7	10.4	-1.7	-2.8	-0.9	-1.5	-2.1	-2.0	-3.2
Number of full sisters	3.7	4.5	8.0	-1.3	1.4	2.4	2.8	2.5	2.6	0.8
Eye problems/disorders: Cataract	3.6	4.2	6.4	0.2	-2.2	-1.9	-1.7	-2.2	-2.5	-2.5
Hearing difficulty/problems: Yes	3.3	5.1	8.7	1.1	2.5	1.7	2.4	2.8	3.0	1.8
Commuting to job workplace: Cycle	3.1	3.8	6.3	-0.9	1.6	2.2	2.5	2.5	2.3	0.3
Waist Hip Ratio (WHR)	3.0	13.7	23.9	-1.6	4.2	4.9	3.5	3.4	3.6	3.9
Ever had bowel cancer screening	3.0	3.5	5.4	-0.3	2.2	1.8	1.7	2.1	2.3	2.0
Multivitamins +/- minerals	2.9	3.6	6.3	0.5	1.7	1.5	2.5	2.5	2.4	1.5
High blood pressure (siblings)	2.9	4.2	7.2	1.4	-0.6	-1.9	-2.7	-2.5	-2.7	-1.5
Shortness of breath walking on level ground	2.9	3.4	4.9	0.3	-2.2	-2.1	-2.1	-1.9	-2.0	-1.5
Systolic blood pressure, automated reading	2.7	7.9	10.8	2.2	-3.1	-3.1	-2.9	-3.0	-3.3	-1.8
Time employed in main current job	2.7	3.1	7.7	2.8	-0.4	-1.5	-2.0	-1.9	-2.1	0.2
Medication: Levothyroxine sodium	2.5	4.2	13.6	-2.5	1.6	3.7	1.3	1.3	1.5	1.1
Nervous feelings	2.5	4.6	12.4	3.5	-0.9	-3.4	-2.2	-1.0	-1.3	0.0
Commuting to job workplace: Car/motor vehicle	2.5	2.8	5.1	0.8	-1.4	-1.6	-2.0	-2.2	-2.3	-0.4
Smoking status: Current	2.5	4.0	5.4	0.5	2.2	1.9	2.2	2.3	2.3	2.0
Handedness (chirality/laterality): Left-handed	2.4	2.8	4.6	0.5	-1.7	-2.1	-1.7	-1.7	-1.4	-2.1
Medication: Seretide 50 evohaler	2.3	2.6	5.3	-2.3	-2.1	0.4	-1.1	-1.1	-1.4	-2.1
Qualifications: College or University degree	2.2	7.1	20.5	1.0	-2.0	-4.5	-2.8	-2.6	-2.6	-1.6
Eye problems/disorders: None of the above	2.1	2.4	5.4	0.4	1.9	1.4	0.7	1.5	1.8	2.3
Type 2 Diabetes (T2D) (2018)	2.0	3.8	9.1	-0.7	-0.5	2.7	3.0	2.2	2.1	-0.2
Age when periods started (menarche)	2.0	4.8	6.5	-0.1	-2.5	-2.4	-2.5	-2.5	-2.5	-1.6
Standing height	2.0	20.3	37.5	0.4	6.1	5.2	3.6	4.3	4.6	5.0
Mouth/teeth dental problems: Bleeding gums	2.0	2.5	4.7	0.6	-1.6	-2.2	-1.6	-1.9	-1.4	-1.3
Qualifications: NVQ or HND or HNC or equivalent	2.0	2.4	6.0	-1.0	1.6	2.5	1.7	1.5	1.2	1.0
Ever had prostate specific antigen (PSA) test	2.0	2.3	4.8	0.7	2.2	0.6	0.9	1.7	1.9	1.8
Diastolic blood pressure, automated reading	2.0	6.0	12.0	0.9	-2.6	-1.9	-2.7	-3.0	-3.5	-1.7
Schizophrenia (2014)	1.9	4.1	11.0	3.0	-1.2	-3.3	-2.0	-1.4	-1.2	0.4
Vitamin and mineral supplements	1.9	2.6	3.7	-0.9	-1.8	-1.0	-1.9	-1.9	-1.7	-1.9
Relative age voice broke	1.9	2.9	4.5	1.2	-1.6	-2.0	-1.6	-2.1	-2.0	-1.1
Lupus	1.8	2.7	7.2	-0.5	2.7	1.9	1.0	1.3	1.6	1.7
Medication: Co-codamol	1.8	2.1	4.7	-0.4	-0.1	0.9	2.2	2.0	1.7	1.4
Current tobacco smoking	1.8	3.0	4.2	0.5	1.8	1.6	2.1	2.0	2.0	1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.8	2.2	3.8	1.2	1.4	0.5	1.8	1.9	1.7	1.4
Hypothyroidism/myxoedema (self-reported)	1.7	3.3	10.5	-2.8	0.5	3.2	1.3	0.9	1.2	-0.1
Birth weight	1.7	3.7	8.6	0.8	0.2	-2.4	-2.9	-2.3	-2.4	-0.3
Schizophrenia (2018)	1.6	3.3	8.9	2.1	-1.4	-3.0	-1.9	-1.5	-1.2	-0.3
Bilateral oophorectomy (both ovaries removed)	1.6	1.9	4.4	-1.1	-0.7	-1.4	-2.1	-1.5	-0.8	-1.5
Qualifications: CSEs or equivalent	1.6	2.1	4.3	-1.0	1.1	2.1	1.8	1.6	1.3	0.7
Hearing difficulty/problems with background noise	1.6	2.5	5.2	0.4	2.3	0.7	1.6	1.9	2.1	1.0
Diabetes (self-reported)	1.6	2.5	7.4	-0.3	-0.1	1.9	2.7	1.7	1.7	-0.8
Suffer from ‘nerves’	1.6	2.5	8.7	3.0	-0.3	-1.8	-1.1	-1.1	-1.4	1.1
Diabetes diagnosed by doctor	1.6	2.6	7.8	-0.4	-0.2	1.8	2.8	1.9	1.8	-0.5
Qualifications: O levels/GCSEs or equivalent	1.5	2.4	2.9	-1.3	-1.6	-1.5	-1.6	-1.6	-1.4	-1.7
Comparative height size at age 10	1.5	8.0	12.1	1.1	3.4	3.5	2.0	2.9	2.7	3.5
Family relationship satisfaction	1.5	1.8	5.9	1.4	-1.2	-2.4	-1.1	-0.6	-1.0	-1.0
Bipolar Disorder or Schizophrenia	1.4	3.4	7.5	2.5	-1.4	-2.7	-2.0	-1.7	-1.1	0.4
LDL Cholesterol	1.4	2.2	5.9	0.2	1.1	0.9	2.4	2.0	1.7	0.8
Triglycerides	1.4	2.3	5.3	1.0	1.3	0.8	1.3	1.8	1.6	2.3
Height	1.4	27.6	56.7	1.5	7.5	5.8	3.9	4.5	5.0	6.4
Medication: Metformin	1.4	2.0	4.8	-0.8	0.8	1.7	2.2	1.5	1.5	0.6
Had other major operations	1.4	1.7	3.3	0.1	-1.7	-0.5	-0.6	-1.5	-1.6	-1.8
Heel bone mineral density (BMD) T-score, automated (right)	1.4	3.2	7.2	2.2	-2.0	-2.7	-1.1	-1.6	-1.6	-0.3
Depression (self-reported)	1.4	1.7	3.3	1.8	-0.9	-1.5	-1.7	-1.3	-0.9	-0.2
Length of working week for main job	1.4	1.6	7.2	1.5	1.3	-0.1	-0.1	0.1	0.2	2.7
Leg fat percentage (right)	1.4	5.0	14.3	-2.5	-3.8	0.0	-0.5	-0.9	-1.5	-3.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.8	3.1	-0.8	1.5	1.7	1.8	1.2	1.3	1.1
Medication: Omeprazole	1.4	1.7	3.9	-0.5	2.0	1.1	1.0	1.4	1.1	1.5
Leg fat percentage (left)	1.4	5.0	13.9	-2.5	-3.7	0.0	-0.5	-0.9	-1.6	-3.4
Worry (Nagel 2018)	1.3	2.8	10.6	3.3	0.3	-1.7	-1.7	-0.8	-1.0	1.1
Hypothyroidism (self reported)	1.3	3.1	8.4	-2.6	0.7	2.9	1.6	1.2	1.5	-0.1
Sensitivity / hurt feelings	1.3	2.2	5.0	1.2	0.9	1.5	2.2	2.0	1.3	0.3
Peak expiratory flow (PEF)	1.3	3.0	6.7	-1.6	1.5	2.6	1.9	1.6	1.7	0.7
Pulse wave reflection index	1.3	1.6	3.3	-0.5	1.8	1.2	0.7	1.0	1.2	1.8
Friendships satisfaction	1.3	1.6	3.3	1.1	-0.8	-1.4	-1.4	-1.5	-1.8	0.1
Qualifications: nursing, teaching	1.3	2.1	7.0	1.2	-0.5	-2.6	-1.3	-1.2	-1.2	-1.0
Alzheimer’s Disease (including proxy)	1.2	1.7	4.3	1.9	-1.1	-2.1	-1.2	-0.8	-0.7	0.8
Major Depression (MDD)	1.2	1.5	4.2	1.2	1.7	0.6	0.5	0.9	0.8	2.0
Osteoporosis (self-reported)	1.2	1.5	3.7	-1.5	0.9	1.9	1.4	0.9	0.8	-0.2
Ovarian Cancer	1.1	1.5	3.0	1.4	-0.5	-1.7	-1.4	-1.0	-1.4	-0.8
Heel T-Score	1.1	9.0	25.5	4.7	-1.2	-5.0	-1.8	-2.3	-2.3	0.1
Cardiovascular Disease	1.1	3.8	6.8	-0.0	-2.1	-1.2	-2.3	-2.3	-2.6	-1.8
High blood pressure	1.1	3.0	4.9	1.6	-1.6	-1.8	-2.0	-1.8	-2.2	-1.0
Body mass index (BMI)	1.1	4.7	15.0	-2.2	-3.9	-0.0	-0.3	-1.0	-1.6	-3.1
Qualifications: None of the above	1.1	2.3	5.7	-0.3	2.1	2.4	1.2	1.3	1.2	1.2
Number of live births	1.1	1.6	3.0	-1.5	1.0	1.7	1.4	0.9	1.4	-0.5
Loud music exposure frequency	1.1	1.2	2.3	0.8	0.3	-1.2	-1.5	-1.5	-1.2	0.1
Body fat percentage	1.1	4.4	13.5	-2.3	-3.7	0.3	0.3	-0.2	-1.1	-3.2
Emphysema/chronic bronchitis	1.1	1.3	3.6	-1.2	-0.0	1.9	1.1	1.0	1.0	0.7
Medication for pain relief, constipation, heartburn	1.1	1.8	3.1	1.6	-0.9	-1.8	-1.6	-1.1	-0.9	-1.4
Hypertension (Self-reported)	1.1	2.9	5.2	1.4	-1.5	-1.6	-2.0	-1.8	-2.3	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.2	4.8	0.5	2.2	1.6	1.1	1.5	1.4	1.5
Commuting to job workplace: Walk	1.1	1.2	3.8	0.4	0.1	-0.2	1.4	2.0	1.5	-0.5
Breast cancer (self-reported)	1.1	1.4	3.4	1.8	0.6	-0.1	0.7	0.9	1.1	1.9
Vascular/heart problems diagnosed by doctor	1.1	3.0	5.4	-1.2	1.3	1.6	2.3	2.0	2.2	0.9
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	3.4	0.2	1.8	0.6	0.6	1.2	1.1	1.5
Crohns Disease (2012)	1.0	1.5	3.6	1.0	-1.6	-1.9	-0.6	-0.9	-0.8	-1.4
Ever used hormone-replacement therapy (HRT)	1.0	1.3	2.8	0.2	1.5	1.4	0.7	1.0	1.7	0.7
Diabetes (mother)	1.0	1.3	2.4	0.9	-1.6	-0.6	-1.0	-1.0	-1.4	-1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	3.4	1.9	1.2	-0.2	0.6	1.2	1.3	0.6
Sitting height	1.0	7.1	15.8	0.6	4.0	2.7	1.9	2.6	2.6	3.0
Arm fat percentage (right)	1.0	4.0	15.4	-1.5	-3.9	-0.3	0.0	-0.2	-1.1	-3.0
Exposure to tobacco smoke at home	1.0	1.1	2.0	0.5	1.4	1.2	1.0	0.8	0.7	1.4
Alcohol intake frequency.	1.0	2.3	4.2	0.3	2.1	1.4	1.5	1.7	1.7	1.3
Supplements: Vitamin C	1.0	1.2	3.8	0.8	0.3	0.6	1.0	1.2	0.9	1.9
Arm fat percentage (left)	1.0	4.1	14.8	-1.8	-3.8	-0.2	0.1	-0.3	-1.2	-3.1
Mood swings	1.0	1.9	4.0	0.2	0.7	1.6	1.7	2.0	1.7	0.4
Ever taken oral contraceptive pill	1.0	1.1	2.4	-1.5	0.1	1.5	1.3	0.7	0.9	-0.5
Medication: Blood pressure	1.0	1.8	3.9	1.2	-0.2	-1.4	-2.0	-1.5	-1.7	0.1
Basal cell carcinoma (self-reported)	1.0	1.2	2.8	-0.4	1.1	0.5	1.2	1.7	1.6	0.4
Ulcerative Colitis	0.9	1.2	2.7	-0.1	1.5	1.0	1.1	0.9	0.8	1.6
BMI	0.9	5.5	19.1	-2.5	-4.4	0.5	0.7	-0.4	-0.9	-3.3
Systolic Blood Pressure	0.9	4.4	11.1	3.3	-0.8	-1.9	-2.3	-2.1	-2.3	0.0
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	4.7	-2.2	-0.8	1.4	-0.1	-0.2	0.0	-1.0
Medication for hormone replacement therapy	0.9	1.0	1.9	-1.1	1.3	1.4	0.4	0.4	1.2	0.2
Trunk fat percentage	0.9	3.6	11.3	-2.1	-3.4	0.5	0.6	0.1	-0.8	-3.0
Serious illness, injury or assault to yourself	0.9	1.1	6.1	-2.5	0.2	0.8	-0.2	-0.1	0.3	-0.8
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.3	0.3	1.2	1.0	1.0	1.5	1.1	0.8
Birth weight of first child	0.9	1.6	4.3	-0.3	1.8	0.9	-0.1	0.9	1.2	2.1
Chronic bronchitis/emphysema (mother)	0.9	1.1	3.1	-1.3	0.7	1.1	1.8	0.9	0.6	-0.1
Exposure to tobacco smoke outside home	0.9	1.2	3.1	-1.8	-0.6	0.5	-0.9	-1.2	-0.9	-1.2
Leg fat mass (right)	0.9	3.5	9.2	-2.7	-3.0	1.1	0.1	-0.4	-0.9	-2.5
Wears glasses or contact lenses	0.9	1.0	3.8	1.4	-0.4	-2.0	-0.6	0.0	0.6	0.5
Pain type(s) experienced in last month: Hip pain	0.9	1.1	2.0	0.7	0.5	0.7	1.3	1.4	1.4	0.8
Medication: Atorvastatin	0.9	1.1	1.8	0.1	0.8	1.1	1.3	1.1	1.2	1.1
Leg fat mass (left)	0.9	3.4	8.3	-2.8	-2.9	1.1	0.1	-0.3	-0.9	-2.4
Schizophrenia vs Biploar Disorder	0.8	1.1	2.1	0.5	-0.3	-1.5	-1.3	-1.1	-1.2	-1.1
Neuroticism (2016)	0.8	1.2	3.7	1.9	1.3	-0.0	-0.2	0.4	0.4	1.6
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.4	0.6	-1.4	-0.8	-0.2	-0.6	-0.8	-1.6
Maternal smoking around birth	0.8	1.2	5.0	-0.1	0.2	2.2	1.6	0.6	0.4	0.1
Illnesses of siblings	0.8	1.1	2.0	-0.3	0.4	1.1	1.4	1.2	1.4	1.0
Happiness	0.8	1.0	3.5	1.7	0.4	-1.9	-0.3	0.1	-0.2	0.4
Noisy workplace	0.8	1.0	3.1	0.1	1.7	0.9	0.2	0.5	0.6	1.5
Medication: Ibuprofen	0.8	1.0	4.8	2.2	-0.1	-0.7	0.3	0.0	0.1	1.2
Had major operations	0.8	0.9	1.8	-0.5	-0.6	1.1	1.2	1.1	1.3	-0.5
Risk taking	0.8	1.2	1.9	-1.2	0.8	1.4	1.2	1.0	1.3	0.6
Unable to work because of sickness or disability	0.8	1.1	3.5	-1.9	-1.0	0.2	-0.7	-0.6	-0.2	-1.4
Depression (Nagel 2018)	0.7	1.0	4.1	2.0	0.6	-1.2	-0.9	-0.2	-0.3	0.7
Ulcerative Colitis (UC)	0.7	1.3	3.2	1.1	1.6	-0.1	0.9	1.0	0.5	1.8
Age at First Birth	0.7	1.0	3.4	1.8	0.1	-1.8	-0.2	-0.2	-0.6	-0.3
Smoking Status	0.7	1.6	3.4	-0.0	1.5	1.5	0.9	0.8	1.3	1.8
Allergy or Eczema	0.7	1.8	5.1	2.3	0.7	-1.4	-0.7	-0.9	-1.1	1.6
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	2.1	-1.0	0.5	1.1	1.4	0.8	0.5	0.2
Fluid intelligence score	0.7	1.4	4.3	0.1	-2.1	-1.5	-0.0	-0.4	-0.5	-1.8
Qualifications: A levels/AS levels or equivalent	0.7	1.5	4.2	-0.0	-0.7	-2.1	-1.3	-0.9	-0.9	-1.5
Tense / ‘highly strung’	0.7	1.1	2.7	1.6	-0.3	-1.2	-1.0	-0.8	-0.5	1.1
Glaucoma (self-reported)	0.7	0.8	3.5	1.9	-0.1	-1.2	0.2	-0.1	-0.3	0.6
Wheeze or whistling in the chest in last year	0.7	1.2	2.8	-0.2	-1.7	-1.1	-0.8	-1.4	-1.2	-0.8
Migraine (self-reported)	0.7	0.9	3.8	-2.0	0.1	1.2	0.4	0.6	0.8	0.2
Whole body fat mass	0.7	2.8	6.4	-2.5	-2.5	1.4	0.7	0.2	-0.4	-2.2
Pulse rate, automated reading	0.7	2.3	6.1	2.5	1.3	0.1	1.4	1.9	0.8	1.5
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	3.3	1.8	0.8	-0.7	-0.2	0.1	0.3	1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.9	1.6	-0.8	-0.8	-1.3	-1.0	-0.5	-0.6	-1.2
Pain experienced in last month	0.7	1.2	1.9	0.1	-1.3	-1.1	-1.3	-1.4	-1.3	-0.2
Alzheimer’s Disease (in father)	0.6	0.6	1.8	1.4	-0.6	-1.0	-0.5	-0.2	0.3	0.9
Crohns Disease (2017)	0.6	1.3	5.9	2.4	-0.1	-1.6	-0.0	0.4	-0.0	0.7
Irritable Bowel Disease (IBD)	0.6	1.5	4.4	2.1	1.0	-0.9	0.6	0.8	0.3	1.7
HDL Cholesterol	0.6	0.9	2.1	0.3	-0.9	-1.5	-0.9	-1.1	-0.8	-0.9
Average weekly spirits intake	0.6	0.8	2.3	-0.7	-1.5	-0.1	0.2	-0.4	-1.0	-1.2
Townsend deprivation index at recruitment	0.6	0.9	3.5	-1.9	0.2	1.0	1.0	0.6	0.4	-0.1
Fed-up feelings	0.6	1.1	3.5	-1.0	-1.9	-0.3	-0.4	-0.3	-0.8	-1.6
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	2.6	-1.0	-0.5	-0.2	-0.0	-0.3	-0.5	-1.6
Chronic bronchitis/emphysema (father)	0.6	0.7	1.9	-0.4	0.8	-0.4	-1.4	-0.9	-0.7	0.5
Trunk fat mass	0.6	2.5	5.9	-2.1	-2.4	1.3	0.9	0.6	-0.2	-2.1
Past tobacco smoking	0.6	1.0	1.9	1.3	-1.1	-1.4	-0.7	-0.4	-1.0	-0.9
Hair/balding pattern: Pattern 2	0.6	0.7	1.8	-1.0	0.9	1.3	0.8	0.6	0.6	0.2
Hip circumference	0.6	2.4	7.3	-1.7	-2.7	0.4	0.1	-0.1	-0.8	-2.4
Falls in the last year	0.6	0.8	1.7	-1.2	-1.0	-0.3	-0.4	-1.0	-1.3	-0.7
Pulse rate	0.6	1.0	3.6	1.9	0.5	0.3	1.0	1.2	0.6	0.6
Medication: Cholesterol lowering	0.6	0.9	1.4	0.1	-0.2	1.1	1.2	1.2	1.1	1.0
Pulse wave Arterial Stiffness index	0.6	0.7	2.4	0.7	1.6	0.3	0.4	0.7	0.6	0.8
Arm fat mass (right)	0.6	2.6	7.1	-2.2	-2.7	1.1	0.7	0.3	-0.4	-2.2
Age at first live birth	0.6	1.0	3.3	1.8	-0.3	-1.7	-0.5	0.1	-0.2	-0.5
Mouth/teeth dental problems: Loose teeth	0.6	0.7	2.0	-0.2	-0.3	-0.6	-1.2	-1.1	-1.4	-0.1
Neck or shoulder pain in last month	0.6	0.9	2.5	-1.6	0.9	1.4	0.3	0.3	0.7	0.6
Medication: Aspirin	0.6	0.9	2.3	-0.1	-0.0	1.0	1.5	1.1	0.9	0.8
Illnesses of father: Heart disease	0.6	0.8	3.6	-1.9	-0.7	0.1	-0.5	-0.4	-0.6	-1.0
Loneliness, isolation	0.6	0.9	2.5	-0.2	0.2	1.0	1.1	1.6	1.1	-0.6
Long-standing illness, disability or infirmity	0.6	0.9	2.8	-1.1	-0.6	1.7	1.1	0.6	0.8	-0.1
Medication: Aspirin	0.6	0.8	1.6	-0.7	-0.3	1.2	1.3	0.9	0.8	0.5
Arm fat mass (left)	0.6	2.5	7.1	-2.1	-2.7	1.0	0.7	0.3	-0.4	-2.1
Average weekly champagne plus white wine intake	0.6	0.9	3.3	1.8	1.0	-0.1	0.8	0.7	0.5	0.8
Average weekly beer plus cider intake	0.6	0.9	2.5	-0.2	1.6	1.0	0.4	0.4	1.0	1.2
Body Mass Index (BMI) (2010)	0.5	0.6	3.0	-1.7	0.6	0.9	0.3	0.0	0.3	0.1
Hand grip strength (left)	0.5	1.2	5.6	2.4	1.2	-0.2	0.6	0.6	0.7	0.4
Frequency of depressed mood in last 2 weeks	0.5	0.7	2.4	1.6	0.2	-0.1	0.7	1.1	0.6	0.7
Average weekly fortified wine intake	0.5	0.6	2.7	1.6	-0.1	-0.7	-0.8	-0.3	-0.5	0.3
Waist circumference	0.5	2.0	5.3	-2.3	-1.5	2.0	1.0	0.6	0.1	-1.0
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	1.9	1.4	0.8	0.4	0.9	1.0	0.9	0.5
Forced vital capacity (FVC)	0.5	1.8	3.8	-0.7	1.2	1.3	1.4	1.6	1.9	0.7
Heart attack	0.5	0.7	1.3	-0.8	-1.0	-0.4	-1.1	-1.0	-0.7	-0.3
Impedance of arm (right)	0.5	2.1	4.2	1.9	1.3	-0.0	1.4	2.0	1.5	1.2
Trunk fat-free mass	0.5	2.8	8.2	-1.0	1.7	2.9	1.1	1.2	1.6	1.7
Alcohol intake versus 10 years previously	0.5	0.7	1.5	-0.3	0.8	1.2	1.2	1.0	0.6	0.2
Worrier / anxious feelings	0.5	1.0	4.0	1.2	2.0	-0.4	-0.3	0.3	0.4	1.1
Mouth/teeth dental problems: Dentures	0.5	0.9	2.0	-0.1	1.4	0.6	0.9	0.7	0.8	1.4
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	2.4	1.6	0.0	-0.4	0.6	0.2	0.5	1.2
Trunk predicted mass	0.5	3.0	8.5	-1.0	1.7	2.9	1.1	1.2	1.6	1.7
Medication: Blood pressure	0.5	0.9	2.1	-0.2	-1.5	0.3	-0.3	-0.8	-1.1	-1.4
Medication: Allopurinol	0.5	0.6	1.4	-0.9	-0.8	-0.0	-0.3	-0.9	-0.9	-1.2
Overall health rating	0.5	1.1	2.3	-1.5	-1.1	0.2	-1.0	-0.9	-1.0	-1.3
Smoking status: Previous	0.5	0.8	3.2	-1.8	-0.2	0.5	-0.8	-1.2	-0.4	-0.1
Guilty feelings	0.5	0.7	2.7	1.6	0.5	-1.1	-0.7	-0.0	-0.3	-0.5
Ever smoked	0.5	0.9	1.8	-1.0	0.7	1.3	1.1	0.7	1.1	0.6
Irritability	0.5	0.9	2.6	-1.2	-1.6	0.6	-0.2	0.0	-0.1	-1.4
Pack years of smoking	0.5	0.7	2.9	-0.2	-0.6	1.1	1.7	0.6	0.5	0.2
Bipolar Disorder (2018)	0.4	0.7	1.8	1.3	-0.5	-0.6	-0.8	-0.9	-0.4	0.9
Intelligence (Savage-Jansen 2018)	0.4	1.3	2.9	-0.7	-1.6	-1.7	-0.5	-1.1	-0.4	-1.2
Alzheimer’s Disease (in mother)	0.4	0.5	1.3	1.0	-0.7	-1.1	-0.6	-0.4	-0.6	0.2
Verbal and Numeric Reasoning (VNR)	0.4	1.0	3.8	-1.9	-1.2	-0.5	0.6	0.1	0.4	-1.1
Blood Platelet Count	0.4	4.1	8.1	-2.8	-2.9	-2.3	-1.6	-1.7	-1.4	-0.5
Supplements: Zinc	0.4	0.4	1.0	0.3	0.3	0.4	0.5	0.9	0.8	1.0
Pack years adult smoking proportion	0.4	0.7	2.3	-0.4	-1.1	0.9	1.5	0.4	0.1	-0.3
Hand grip strength (right)	0.4	1.1	2.3	1.5	1.2	0.6	1.0	1.0	0.9	1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	2.3	1.5	-1.1	-1.3	-0.6	-0.9	-0.7	0.4
High blood pressure (mother)	0.4	0.6	1.6	0.2	0.2	0.1	-1.2	-1.0	-1.2	0.1
Number of incorrect matches in round	0.4	0.6	1.2	0.6	0.1	0.9	0.7	1.0	0.6	1.1
Medication: Simvastatin	0.4	0.5	1.9	1.4	-0.9	-0.7	0.1	0.2	0.2	0.5
Father’s age at death	0.4	0.6	1.6	1.2	-0.6	-1.1	-0.2	0.3	0.5	0.6
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.7	-0.4	-0.0	0.5	1.1	1.3	1.3	-0.1
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	2.1	-0.7	1.2	1.2	1.3	1.4	1.4	0.5
Prospective memory result	0.4	0.4	1.7	0.2	1.3	0.7	0.0	0.6	0.7	0.0
Lung cancer (father)	0.4	0.5	1.5	1.2	-0.8	-0.3	-0.2	-0.1	-0.6	-1.0
Impedance of arm (left)	0.4	2.0	3.8	1.5	1.6	0.3	1.5	1.9	1.4	1.2
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	1.3	0.2	0.8	-1.1	-0.9	-0.9	-0.7	0.1
Gout (self-reported)	0.4	0.5	1.9	-0.1	-1.4	-0.2	-0.1	-0.6	-0.5	-0.9
Arm fat-free mass (right)	0.4	2.0	6.5	-2.0	0.6	2.5	1.1	0.6	1.0	0.5
Health satisfaction	0.4	0.6	3.1	-0.2	0.1	-0.2	-0.3	-0.5	-0.8	-1.8
Average weekly red wine intake	0.4	0.6	2.4	1.2	-0.3	-1.6	-0.3	-0.3	-0.3	0.4
Illnesses of father: None of the above (group 1)	0.4	0.5	1.7	0.1	0.2	0.6	1.3	0.8	0.7	0.5
Miserableness	0.4	0.7	3.2	-0.9	-0.7	0.7	0.3	-0.1	-0.4	-1.8
Financial situation satisfaction	0.4	0.4	1.2	1.0	0.2	-1.1	0.4	0.5	-0.2	0.5
Eye problems/disorders: Glaucoma	0.4	0.5	1.2	1.1	0.7	0.5	0.8	0.0	-0.1	0.9
Medication: Lisinopril	0.4	0.5	1.0	0.7	-0.1	-0.9	-1.0	-0.8	-0.9	0.1
Illnesses of father: High blood pressure	0.4	0.5	1.5	1.2	0.8	-0.6	-0.8	-0.3	-0.3	0.2
Myopia	0.4	0.6	1.9	1.2	-0.0	-1.4	0.4	0.2	0.2	0.6
Heart attack/myocardial infarction (self-reported)	0.4	0.6	1.4	-1.2	-0.7	-0.0	-1.0	-0.9	-0.5	-0.2
Depressed Affect (Nagel 2018)	0.3	0.7	1.8	-0.9	-0.2	1.3	0.6	1.1	0.5	-0.6
Reaction Time	0.3	0.6	1.4	-1.0	-0.5	1.2	1.2	0.4	-0.0	-0.7
Type 2 Diabetes (T2D) (2012)	0.3	0.3	1.0	-0.5	-0.1	-0.2	-0.2	-0.8	-1.0	0.2
Number of treatments/medications taken	0.3	0.5	1.4	0.5	0.2	1.2	1.0	0.5	0.1	0.9
Ever had hysterectomy (womb removed)	0.3	0.3	0.8	-0.5	-0.4	-0.9	-0.7	-0.5	0.3	-0.5
Severe depression (siblings)	0.3	0.3	0.9	0.9	0.3	-0.2	-0.4	-0.4	-0.7	0.5
Pain all over the body in last month	0.3	0.3	1.2	-0.2	-0.9	-0.2	0.1	0.1	0.2	-1.1
Weight	0.3	1.7	4.4	-1.9	-1.1	2.1	1.2	0.8	0.4	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	0.5	0.7	-0.7	-0.7	-0.5	-0.5	-0.4	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	1.7	-1.0	0.7	1.3	1.3	1.1	1.0	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.8	0.5	0.5	-0.7	-0.1	-0.1	0.1	1.4
Hair/balding pattern: Pattern 4	0.3	0.7	2.7	1.6	-1.3	-0.2	-0.3	0.1	-0.3	-0.5
Medication: Paracetamol	0.3	0.6	2.7	-1.6	0.6	0.8	0.5	0.2	0.2	0.1
Headache pain in last month	0.3	0.5	1.2	1.1	0.5	0.3	0.6	1.1	0.7	0.5
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.3	-0.1	-1.1	0.4	-0.7	-0.5	-0.5	-0.2
Forced vital capacity (FVC), Best measure	0.3	1.2	2.2	-1.2	0.4	1.5	1.3	1.2	1.3	-0.1
Comparative body size at age 10	0.3	0.8	1.7	-1.3	0.6	1.3	0.2	0.6	1.0	0.5
Worry too long after embarrassment	0.3	0.4	2.1	1.4	0.7	-0.5	0.2	0.1	0.1	-0.4
Pulse wave peak to peak time	0.3	0.3	1.1	-0.8	-1.0	0.2	-0.1	-0.3	-0.2	-0.5
Mean time to correctly identify matches	0.3	0.5	0.9	-0.8	-0.8	0.8	0.9	0.2	-0.0	-0.8
Arm predicted mass (right)	0.3	1.7	5.9	-1.9	0.6	2.4	0.8	0.4	0.8	0.5
Age at last live birth	0.3	0.4	0.7	0.6	0.7	-0.4	0.4	0.8	0.8	-0.3
Knee pain experienced in last month	0.3	0.5	1.7	-0.4	-1.3	-0.5	0.2	-0.5	-0.6	-0.7
Whole body fat-free mass	0.3	1.7	5.9	-1.2	0.8	2.4	0.9	0.9	1.1	0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	1.2	-1.1	-0.2	0.4	-0.5	-0.6	-0.4	0.1
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.5	1.1	-0.6	-1.2	-0.6	-0.4	-0.4	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.7	0.2	-0.8	0.0	-0.7	-0.6	-0.8	-0.2
Back pain experienced in last month	0.3	0.5	1.1	0.9	0.1	-0.1	0.6	1.0	1.0	0.2
Asthma (self-reported)	0.3	0.6	1.4	0.4	-1.2	-0.8	-0.6	-0.8	-0.9	0.2
Osteoarthritis (self-reported)	0.3	0.4	1.1	-1.0	-1.1	-0.1	0.4	0.1	0.2	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	2.8	-1.7	-0.0	0.3	0.7	0.7	0.6	-0.4
Whole body water mass	0.3	1.6	5.6	-1.2	0.7	2.4	0.9	0.9	1.1	0.9
Mother’s age at death	0.3	0.4	0.9	-0.1	-0.1	-0.9	-0.5	-0.9	-0.9	-0.3
Commuting to job workplace: Public transport	0.3	0.4	1.9	-1.4	-0.0	0.2	0.6	0.5	0.1	-0.3
Medication: Bendroflumethiazide	0.3	0.4	1.1	0.8	0.4	0.0	-1.0	-0.5	-0.6	0.6
Basal metabolic rate	0.3	1.7	5.9	-1.5	0.3	2.4	1.1	1.0	1.0	0.5
Arm fat-free mass (left)	0.3	1.5	5.6	-1.7	0.2	2.4	0.8	0.6	0.7	0.4
Fractured/broken bones in last 5 years	0.3	0.3	1.4	-1.2	-0.4	0.2	0.4	0.3	0.4	-0.5
Age started oral contraceptive pill	0.3	0.3	0.6	-0.7	0.7	0.8	0.4	0.4	0.6	-0.4
Alcohol drinker status: Previous	0.3	0.4	0.8	-0.5	0.1	0.5	0.9	0.8	0.8	0.1
Impedance of whole body	0.3	1.7	3.1	1.1	1.8	0.6	1.3	1.6	1.3	1.1
Arm predicted mass (left)	0.3	1.5	5.6	-1.8	0.1	2.4	0.8	0.5	0.7	0.1
Neuroticism (Nagel 2018)	0.2	0.5	2.8	1.7	0.5	-0.1	-0.0	0.6	0.2	0.4
Bipolar Disorder (2011)	0.2	0.2	0.5	-0.4	-0.1	-0.6	-0.5	-0.4	-0.2	-0.7
Fasting Glucose	0.2	0.2	0.5	0.2	-0.5	-0.1	-0.5	-0.5	-0.6	-0.7
HbA1C	0.2	0.2	0.9	0.0	0.3	0.5	1.0	0.4	0.4	-0.0
Primary Biliary Cirrhosis	0.2	0.3	1.0	-1.0	0.1	0.8	-0.3	-0.3	-0.5	-0.2
Rheumatoid Arthritis	0.2	0.3	1.1	-1.0	0.0	1.0	0.3	0.2	0.1	-0.2
Blood Red Count	0.2	1.9	4.5	0.6	2.1	2.0	1.4	0.8	1.4	-0.4
Blood White Count	0.2	1.7	5.7	2.4	-0.5	-2.4	-0.1	-0.5	-0.3	-0.1
Neuroticism	0.2	0.4	2.1	1.4	0.4	-0.5	-0.4	0.2	-0.1	0.3
Chronotype (morning person)	0.2	0.5	0.8	-0.9	-0.6	0.9	-0.3	0.6	0.9	-0.4
Impedance of leg (right)	0.2	1.0	2.9	0.8	1.7	0.5	0.8	1.0	1.0	1.0
Leg fat-free mass (left)	0.2	1.1	3.5	-1.4	-0.2	1.9	0.8	0.8	0.8	0.2
Hayfever, allergic rhinitis or eczema	0.2	0.5	2.6	0.8	0.6	-0.1	0.3	0.2	-0.1	1.6
Stomach or abdominal pain in last month	0.2	0.3	0.8	-0.8	-0.2	0.9	0.3	0.6	0.4	-0.0
Medication: Atenolol	0.2	0.3	0.5	-0.5	-0.4	-0.2	-0.6	-0.7	-0.4	-0.4
Impedance of leg (left)	0.2	0.9	2.7	0.6	1.6	0.6	0.8	1.0	0.8	0.7
Leg predicted mass (left)	0.2	1.2	3.8	-1.4	-0.1	1.9	0.9	0.8	0.9	0.3
Alcohol usually taken with meals	0.2	0.3	0.8	0.9	0.6	-0.7	0.3	-0.1	-0.3	0.5
Financial difficulties in last 2 years	0.2	0.3	0.9	-0.8	-1.0	0.5	0.4	0.3	0.1	-0.3
Mouth/teeth dental problems	0.2	0.3	0.7	-0.5	-0.6	0.7	-0.4	-0.1	-0.3	-0.8
Allergy	0.2	0.4	2.4	-0.7	0.0	-0.1	-0.3	-0.1	0.2	-1.5
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.6	0.7	-0.7	-0.8	0.7	0.0	0.0	-0.2
Neuroticism score	0.2	0.5	2.6	1.6	0.0	-0.9	-0.4	0.2	0.0	-0.1
Asthma	0.2	0.3	0.5	0.3	-0.7	-0.5	-0.4	-0.6	-0.6	0.6
Illnesses of mother	0.2	0.2	0.7	-0.4	0.5	0.3	0.3	0.3	0.8	-0.3
Breastfed as a baby	0.2	0.3	0.8	-0.6	-0.6	0.3	0.6	0.4	0.9	0.1
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.7	0.0	0.5	0.4	-0.0	0.5	0.4	0.8
Number of full brothers	0.2	0.3	1.6	-1.3	-0.3	0.5	0.3	-0.3	-0.2	-0.0
Number of children fathered	0.2	0.3	0.7	-0.8	-0.2	0.9	0.5	0.1	0.3	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.4	0.7	0.1	-0.5	-0.6	-0.5	0.3	0.3
Angina (self-reported)	0.2	0.2	0.6	0.5	0.2	-0.7	-0.8	-0.6	0.1	0.1
Heart disease (mother)	0.2	0.2	0.5	-0.3	0.3	-0.2	-0.5	-0.5	-0.7	-0.4
Leg pain on walking	0.2	0.3	0.6	-0.1	0.4	0.4	-0.4	-0.6	-0.7	-0.7
Leg fat-free mass (right)	0.2	1.3	4.2	-1.5	0.1	2.1	1.0	0.9	0.8	0.2
Leg predicted mass (right)	0.2	1.2	4.0	-1.6	0.1	2.0	0.9	0.8	0.7	0.3
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.6	0.2	0.8	-0.3	-0.7	-0.4	-0.1	0.5
High cholesterol (Self-reported)	0.2	0.3	1.5	1.2	0.2	-0.2	0.5	0.1	0.1	0.6
Number of operations (self-reported)	0.2	0.2	0.8	0.4	0.5	0.2	0.9	0.6	0.4	-0.0
Cholesterol lowering medication	0.2	0.3	0.8	0.9	-0.0	-0.6	-0.6	-0.7	-0.5	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.7	-0.5	-0.8	0.2	0.3	-0.2	-0.0	-0.8
Breast Cancer	0.1	0.1	0.4	-0.4	0.1	0.2	-0.2	-0.6	-0.5	0.1
Prostate Cancer	0.1	0.1	0.3	-0.1	-0.4	-0.6	-0.0	0.2	0.2	-0.5
Coronary Artery Disease (CAD)	0.1	0.2	0.6	0.5	0.1	-0.7	-0.5	-0.2	0.1	-0.2
Mean Putamen Volume	0.1	0.1	0.6	0.5	-0.8	-0.1	0.1	-0.1	-0.0	-0.2
Blood Eosinophil Count	0.1	1.0	2.8	-1.5	0.1	0.0	1.7	0.9	0.9	0.7
Respiratory disease	0.1	0.1	0.6	0.7	-0.4	-0.3	-0.0	0.1	-0.1	0.4
Lung FVC	0.1	0.7	1.3	-1.0	-1.1	-0.5	0.6	0.7	1.0	-0.7
Tanning	0.1	0.8	1.9	0.7	0.4	-0.2	1.4	1.2	0.9	0.8
Relative age of first facial hair	0.1	0.2	0.5	-0.2	0.1	-0.3	-0.2	-0.7	-0.7	0.2
Angina	0.1	0.1	0.3	0.3	0.3	-0.5	-0.6	-0.4	0.2	0.1
Had menopause	0.1	0.2	0.5	-0.7	-0.3	-0.4	-0.5	-0.1	0.4	0.1
Medication: Ramipril	0.1	0.2	1.0	-0.0	1.0	0.2	0.0	0.1	-0.1	0.4
Hair/balding pattern: Pattern 3	0.1	0.1	0.3	0.2	-0.4	-0.4	0.5	0.4	0.5	0.0
Medication: Lansoprazole	0.1	0.1	0.6	-0.3	-0.2	-0.7	0.1	0.0	0.4	-0.1
Blood clot in the leg (DVT)	0.1	0.1	0.2	-0.3	-0.5	0.2	0.3	-0.1	0.1	-0.4
Medication: Amlodipine	0.1	0.2	0.3	0.4	0.5	-0.1	-0.6	-0.1	-0.4	0.5
Chest pain or discomfort	0.1	0.2	0.5	-0.6	-0.2	-0.7	-0.4	-0.4	-0.1	0.4
Medication for cholesterol	0.1	0.2	0.4	-0.4	-0.6	-0.5	0.2	0.1	-0.0	-0.7
Mineral and other dietary supplements	0.1	0.1	0.4	-0.3	0.2	-0.7	0.2	-0.0	0.2	-0.6
Number of self-reported non-cancer illnesses	0.1	0.2	0.4	0.6	-0.4	-0.1	0.3	0.3	0.5	0.3
Hearing aid user	0.1	0.1	0.3	0.2	-0.4	-0.1	0.0	0.3	0.6	-0.0
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.3	0.6	-0.6	0.3	-0.3	-0.0	-0.5	-0.1
Medication: Paracetamol	0.1	0.1	0.4	-0.3	0.4	-0.0	0.6	0.4	0.2	0.2
Ever depressed for a whole week	0.1	0.1	0.2	-0.2	-0.0	0.5	-0.3	0.1	-0.1	0.3
Heart disease (siblings)	0.1	0.2	0.4	-0.6	-0.3	0.1	0.6	0.4	0.5	0.1
Lung FEV1/FVC ratio	0.0	0.1	0.3	-0.4	0.4	0.5	0.0	-0.1	-0.4	0.5
Hair Pigment	0.0	0.9	2.4	-0.3	-1.6	-0.7	-1.2	-0.9	-0.6	-0.8
Supplements: Glucosamine	0.0	0.1	0.2	0.3	-0.1	0.2	0.3	0.1	0.0	0.4

Hub : Genes

PLEKHG3

Models

Trait associations