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chr1:18,704,862-24,216,118

Best TWAS P=1.95e-20 · Best GWAS P=8.05e-21 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CAPZB	0.13	0.16	lasso	4	0.16	1.8e-19	5.4	-6.0	1.8e-09	0.06	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	HTR1D	0.11	0.07	enet	21	0.09	1.1e-10	-6.6	7.4	1.6e-13	0.03	0.06	0.94	TRUE
3	CommonMind	Brain Pre-frontal Cortex	KIF17	0.25	0.19	bslmm	476	0.21	8.2e-25	-6.3	5.7	1.3e-08	0.18	0.98	0.02	FALSE
4	GTEx	Artery Aorta	CAPZB	0.14	0.10	lasso	6	0.10	5.0e-06	7.5	-7.1	1.7e-12	0.06	0.80	0.19	FALSE
5	GTEx	Artery Coronary	CAPZB	0.25	0.02	enet	22	0.03	3.3e-02	6.4	-5.8	7.6e-09	0.05	0.08	0.10	FALSE
6	GTEx	Artery Tibial	CAPZB	0.09	0.07	lasso	4	0.06	8.1e-06	6.4	-7.4	1.5e-13	0.10	0.55	0.26	FALSE
7	GTEx	Artery Tibial	LUZP1	0.25	0.02	enet	51	0.11	3.4e-09	-7.2	5.5	4.8e-08	0.11	0.05	0.93	TRUE
8	GTEx	Brain Caudate basal ganglia	KIF17	0.22	0.18	lasso	3	0.19	4.7e-06	-5.9	5.9	3.0e-09	0.18	0.08	0.69	FALSE
9	GTEx	Brain Cerebellar Hemisphere	AKR7L	0.26	0.00	enet	4	-0.01	7.3e-01	2.9	5.3	9.0e-08	0.02	0.05	0.54	FALSE
10	GTEx	Brain Cerebellum	HP1BP3	0.27	0.07	lasso	4	0.03	3.8e-02	6.2	7.3	3.8e-13	0.26	0.06	0.26	FALSE
11	GTEx	Brain Cortex	LUZP1	0.23	0.14	lasso	5	0.10	7.8e-04	-7.2	7.2	6.2e-13	0.02	0.04	0.59	FALSE
12	GTEx	Brain Frontal Cortex BA9	RP1-184J9.2	0.38	0.00	lasso	11	0.00	4.3e-01	-7.4	5.8	7.1e-09	0.00	0.02	0.54	TRUE
13	GTEx	Brain Hippocampus	LINC00339	0.41	0.08	lasso	8	0.13	5.1e-04	5.9	5.8	9.0e-09	-0.10	0.05	0.68	FALSE
14	GTEx	Brain Putamen basal ganglia	OTUD3	0.36	0.11	enet	16	0.04	4.7e-02	-1.6	-5.6	2.6e-08	0.11	0.04	0.57	FALSE
15	GTEx	Cells Transformed fibroblasts	UBR4	0.24	0.05	enet	26	0.09	1.8e-07	1.4	5.5	4.5e-08	0.00	0.89	0.03	FALSE
16	GTEx	Cells Transformed fibroblasts	LUZP1	0.09	0.09	lasso	4	0.08	2.8e-06	-7.2	7.2	4.6e-13	0.02	0.03	0.97	TRUE
17	GTEx	Cells Transformed fibroblasts	RP5-930J4.4	0.05	0.00	lasso	2	0.00	2.4e-01	5.8	-6.0	1.9e-09	-0.12	0.11	0.38	FALSE
18	GTEx	Esophagus Muscularis	LUZP1	0.17	0.15	enet	20	0.16	8.8e-10	-6.6	5.3	1.4e-07	0.03	0.04	0.96	FALSE
19	GTEx	Esophagus Muscularis	RP1-184J9.2	0.07	0.08	enet	6	0.05	6.1e-04	-6.6	6.6	4.9e-11	0.04	0.20	0.73	FALSE
20	GTEx	Heart Atrial Appendage	EIF4G3	0.23	0.06	lasso	6	0.03	1.1e-02	-8.8	-8.2	3.6e-16	-0.25	0.27	0.37	FALSE
21	GTEx	Lung	PQLC2	0.12	0.10	lasso	3	0.08	1.0e-06	-5.6	5.3	1.1e-07	-0.13	0.98	0.01	FALSE
22	GTEx	Lung	EIF4G3	0.08	0.03	lasso	3	0.02	5.7e-03	5.2	-5.5	4.5e-08	-0.11	0.78	0.08	FALSE
23	GTEx	Muscle Skeletal	LUZP1	0.07	0.08	enet	14	0.08	3.5e-08	4.4	6.0	2.7e-09	0.02	0.26	0.73	FALSE
24	GTEx	Nerve Tibial	PQLC2	0.07	0.08	lasso	3	0.06	6.6e-05	-7.0	7.0	1.9e-12	-0.11	0.46	0.40	FALSE
25	GTEx	Nerve Tibial	CAPZB	0.07	0.03	enet	14	0.01	3.5e-02	7.6	-6.5	1.2e-10	0.03	0.55	0.20	FALSE
26	GTEx	Pancreas	LINC00339	0.33	0.18	enet	12	0.18	3.5e-08	5.9	-7.2	4.1e-13	0.01	0.09	0.89	FALSE
27	GTEx	Skin Sun Exposed Lower leg	KDM1A	0.09	0.01	lasso	5	0.01	1.1e-01	-7.3	-6.3	2.3e-10	0.02	0.02	0.89	FALSE
28	GTEx	Skin Sun Exposed Lower leg	LUZP1	0.07	0.03	enet	13	0.07	1.2e-06	-4.5	5.5	3.9e-08	0.06	0.05	0.87	FALSE
29	GTEx	Small Intestine Terminal Ileum	KIF17	0.24	0.04	lasso	7	0.02	1.3e-01	-9.1	-8.5	2.4e-17	-0.24	0.02	0.83	TRUE
30	GTEx	Testis	KIF17	0.19	0.23	lasso	4	0.23	9.7e-11	-5.9	6.0	1.6e-09	0.18	0.94	0.06	FALSE
31	GTEx	Testis	LUZP1	0.17	0.09	lasso	4	0.08	2.6e-04	-7.4	-7.8	7.2e-15	0.02	0.01	0.96	FALSE
32	GTEx	Thyroid	CAPZB	0.22	0.06	lasso	8	0.15	1.1e-11	6.8	-5.6	2.2e-08	0.08	0.64	0.36	FALSE
33	GTEx	Uterus	ALPL	0.42	-0.01	lasso	8	0.02	1.4e-01	1.0	-7.6	4.0e-14	-0.42	0.03	0.40	TRUE
34	GTEx	Whole Blood	HP1BP3	0.04	0.04	lasso	4	0.02	6.3e-03	-7.1	-7.3	2.8e-13	-0.21	0.59	0.23	FALSE
35	GTEx	Whole Blood	RP5-930J4.4	0.07	0.09	lasso	5	0.09	1.0e-08	-7.1	-7.2	7.1e-13	-0.22	0.66	0.34	FALSE
36	GTEx	Whole Blood	LINC00339	0.23	0.11	lasso	5	0.14	1.2e-12	6.0	5.7	1.5e-08	-0.08	0.99	0.01	FALSE
37	ROSMAP	Brain Pre-frontal Cortex	PQLC2	0.13	0.05	lasso	8	0.10	2.7e-12	6.5	6.1	1.3e-09	0.00	0.97	0.03	FALSE
38	ROSMAP	Brain Pre-frontal Cortex	CDC42	0.07	0.02	lasso	6	0.04	5.7e-06	7.0	9.3	2.0e-20	-0.01	0.03	0.96	TRUE
39	ROSMAP	Brain Pre-frontal Cortex	CAPZB	0.28	0.39	lasso	4	0.38	9.4e-52	5.4	-5.5	4.5e-08	0.08	1.00	0.00	FALSE
40	ROSMAP	Brain Pre-frontal Cortex	HTR1D	0.10	0.10	lasso	4	0.12	1.3e-14	-6.6	6.5	6.5e-11	0.05	0.13	0.87	TRUE
41	YFS	Blood	CAPZB	0.06	0.10	bslmm	534	0.09	5.1e-29	5.4	-5.2	2.6e-07	0.07	1.00	0.00	FALSE
42	YFS	Blood	LUZP1	0.01	0.00	blup	407	0.01	1.8e-03	5.5	6.1	1.2e-09	0.03	0.08	0.64	TRUE
43	The Cancer Genome Atlas	Breast Invasive Carcinoma	HP1BP3	0.01	0.00	blup	52	0.00	4.2e-02	5.5	6.6	3.3e-11	0.12	0.04	0.28	FALSE
44	The Cancer Genome Atlas	Breast Invasive Carcinoma	WNT4	0.03	0.01	blup	72	0.02	3.8e-05	4.4	6.3	3.2e-10	0.02	0.47	0.06	TRUE
45	The Cancer Genome Atlas	Colon Adenocarcinoma	HTR1D	0.10	0.07	enet	7	0.08	3.8e-05	-7.2	7.5	4.5e-14	0.02	0.02	0.98	TRUE
46	The Cancer Genome Atlas	Esophageal Carcinoma	KIF17	0.16	0.07	blup	92	0.07	3.6e-03	3.8	6.0	2.2e-09	0.21	0.04	0.11	FALSE
47	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CAPZB	0.03	0.00	blup	160	0.01	3.3e-02	-7.1	-8.4	3.0e-17	0.12	0.05	0.72	TRUE
48	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	HTR1D	0.24	0.12	lasso	4	0.12	1.2e-05	-7.4	7.9	2.2e-15	-0.01	0.00	0.99	TRUE
49	The Cancer Genome Atlas	Rectum Adenocarcinoma	HTR1D	0.19	0.12	enet	11	0.13	7.3e-04	-7.2	7.5	5.9e-14	0.03	0.02	0.83	FALSE
50	The Cancer Genome Atlas	Thyroid Carcinoma	CAPZB	0.08	0.06	blup	160	0.07	1.2e-07	6.4	-6.4	1.9e-10	0.10	0.05	0.95	FALSE