Hub : Genes

N4BP2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.0841	0.0354	9.4e-03	0.026	NA	0.026	NA	0.035	3.8e-03	NA	3.7e-03	NA	9.7e-04
2	GTEx	Esophagus Mucosa	0.2870	0.0600	4.8e-07	0.086	NA	0.081	NA	0.103	2.2e-06	NA	4.4e-06	NA	2.2e-07
3	GTEx	Muscle Skeletal	0.1058	0.0357	2.8e-04	0.116	NA	0.127	NA	0.124	1.9e-11	NA	1.9e-12	NA	3.4e-12
4	GTEx	Stomach	0.1260	0.0530	8.4e-03	0.009	NA	-0.002	NA	-0.001	1.1e-01	NA	4.3e-01	NA	3.9e-01
5	NTR	Blood	0.0285	0.0101	2.0e-04	0.008	0.006	0.001	0.006	0.003	8.3e-04	4.0e-03	1.6e-01	3.6e-03	3.5e-02
6	ROSMAP	Brain Pre-frontal Cortex	0.1200	0.0293	1.2e-07	0.096	0.060	0.078	0.086	0.091	2.2e-12	3.5e-08	2.6e-10	3.9e-11	8.2e-12
7	YFS	Blood	0.2571	0.0300	0.0e+00	0.308	0.275	0.318	0.315	0.318	2.8e-103	3.0e-90	5.5e-107	7.0e-106	5.8e-107
8	TCGA	Breast Invasive Carcinoma	0.0250	0.0127	8.5e-03	0.006	0.009	0.007	NA	0.006	2.0e-02	4.2e-03	1.1e-02	NA	1.8e-02
9	TCGA	Head and Neck Squamous Cell Carcinoma	0.0704	0.0310	5.6e-04	0.021	0.031	0.019	NA	0.020	1.8e-03	1.9e-04	2.6e-03	NA	2.1e-03
10	TCGA	Brain Lower Grade Glioma	0.0761	0.0293	5.2e-05	0.002	0.046	0.019	NA	0.017	1.6e-01	4.9e-06	2.7e-03	NA	4.5e-03
11	TCGA	Prostate Adenocarcinoma	0.0598	0.0278	1.0e-04	0.068	0.040	0.053	NA	0.064	1.3e-07	4.8e-05	2.9e-06	NA	3.1e-07

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.3	0.4	2.1	0.0	-0.2	-0.9	-0.9	0.1	-0.6	-0.3	-0.0	-1.4	-0.2	0.4
Bipolar Disorder or Schizophrenia	0.2	0.5	2.5	0.6	-0.6	0.9	-0.7	-0.3	-0.2	0.0	-0.3	-1.6	-0.1	0.9
Depressed Affect (Nagel 2018)	1.2	2.5	7.1	2.5	2.4	1.1	1.6	0.5	-0.6	-0.4	1.6	0.9	0.8	2.7
Depression (Nagel 2018)	0.9	1.4	4.1	2.0	2.0	0.4	0.6	0.8	0.5	0.8	0.9	0.4	0.2	2.0
Intelligence (Savage-Jansen 2018)	0.6	1.9	7.0	0.4	-1.0	-1.7	-2.6	1.8	-0.3	0.3	-0.3	-2.3	0.3	1.1
Neuroticism (Nagel 2018)	0.9	2.0	7.4	2.5	0.9	1.8	0.2	1.9	0.2	0.6	-0.1	-0.9	-0.1	2.7
Schizophrenia (2018)	0.3	0.6	3.0	0.8	-0.7	1.7	-0.1	-0.5	0.3	0.3	-0.4	-0.9	-0.1	0.9
Schizophrenia vs Biploar Disorder	0.7	0.9	4.4	-0.1	-0.5	2.1	1.0	-0.5	1.4	1.0	-0.7	0.8	-0.4	0.0
Worry (Nagel 2018)	0.5	1.1	5.5	1.4	0.5	2.3	0.4	0.6	0.4	0.6	-0.2	-0.1	0.5	1.6
Alzheimer’s Disease (in mother)	0.4	0.5	1.5	-0.4	0.3	-0.3	-0.3	1.2	0.9	1.2	0.1	-0.8	-0.7	-0.5
Alzheimer’s Disease (in father)	0.3	0.4	1.7	-0.3	-0.6	0.6	-0.2	0.2	0.1	0.1	-1.0	-1.3	-0.2	-0.6
Alzheimer’s Disease (including proxy)	1.1	1.6	4.8	-0.9	-0.9	-0.9	-1.2	0.8	0.6	1.1	-1.7	-2.2	-1.5	-1.5
Crohns Disease (2017)	0.4	0.9	2.9	0.8	-1.5	0.3	-1.7	0.7	-0.7	-0.3	-0.9	-0.7	-1.2	0.2
Irritable Bowel Disease (IBD)	0.1	0.3	1.3	0.8	0.1	0.1	-0.8	1.1	-0.1	0.0	-0.5	0.3	-0.4	0.4
Ulcerative Colitis (UC)	0.2	0.4	1.9	0.3	1.4	-0.3	0.6	0.7	0.5	0.3	-0.3	1.0	0.4	0.2
Major Depression (MDD)	0.5	0.6	1.7	1.0	0.4	1.1	0.7	-1.3	-1.0	-0.9	-0.4	-0.1	-0.4	0.6
Reaction Time	2.8	5.3	16.5	-1.9	3.2	-0.6	2.5	-3.5	1.0	0.1	1.6	4.1	0.8	-2.2
Verbal and Numeric Reasoning (VNR)	0.8	2.0	7.4	1.5	-0.8	-1.1	-2.7	1.0	0.5	0.8	0.1	-2.4	0.8	1.5
Breast Cancer	0.6	1.5	6.6	-0.9	-0.8	1.9	0.8	-2.6	-0.9	-1.4	-0.3	0.9	0.1	-1.0
Ovarian Cancer	0.5	0.6	2.4	-0.8	-0.8	0.9	-1.5	1.2	0.6	0.6	0.2	-0.3	-0.1	-0.5
Prostate Cancer	0.7	1.0	3.3	0.8	1.1	-1.1	0.3	1.1	-0.4	-0.3	1.8	1.1	1.0	1.1
Age at First Birth	1.0	1.5	3.7	-0.7	-1.0	-0.3	-1.9	-0.7	1.7	1.3	-1.6	-1.2	-1.1	-0.6
Bipolar Disorder (2011)	0.8	0.8	2.5	-0.7	-0.0	-1.0	-1.2	0.6	0.9	0.8	-0.9	-0.7	-1.6	-0.3
Body Mass Index (BMI) (2010)	0.4	0.5	1.8	-1.0	0.4	-0.6	0.3	-0.1	0.4	0.5	-0.5	-0.3	-1.2	-1.3
Coronary Artery Disease (CAD)	1.9	2.3	8.3	1.4	-2.1	0.3	-0.9	2.2	-0.3	0.3	-1.6	-2.9	-0.3	1.5
Crohns Disease (2012)	0.7	1.1	2.9	-0.4	-1.6	-0.9	-1.1	0.1	-0.2	0.1	-1.2	-1.3	-1.7	-1.2
Mean Putamen Volume	0.4	0.4	1.9	-0.2	1.0	-1.4	0.9	0.5	-0.1	0.0	0.3	0.1	-0.5	-0.7
Fasting Glucose	0.5	0.6	2.3	-0.6	-1.5	0.1	-1.1	1.4	0.3	0.4	-0.6	-0.5	0.0	-0.5
HbA1C	2.5	2.8	8.0	1.5	0.4	1.3	0.5	0.1	-1.5	-1.8	2.5	1.9	2.8	1.8
HDL Cholesterol	0.5	0.8	4.7	-0.1	0.8	0.7	0.2	-2.2	0.1	-0.2	1.0	0.6	1.2	0.2
LDL Cholesterol	0.6	1.0	4.3	-0.9	-0.0	-2.1	-0.6	1.1	0.2	0.5	1.1	0.1	-1.0	-1.4
Lupus	2.2	3.3	8.9	-3.0	0.3	-2.0	-0.8	0.4	2.1	1.8	-1.2	-0.1	-2.5	-2.8
Neuroticism (2016)	0.7	1.0	3.1	1.4	0.6	0.7	0.6	1.8	-0.8	-0.4	0.1	-0.7	0.4	1.7
Primary Biliary Cirrhosis	0.4	0.5	1.7	-0.3	1.3	-1.2	1.0	-0.5	0.0	-0.1	0.5	1.0	-0.1	-0.5
Rheumatoid Arthritis	1.6	2.2	6.1	-2.5	-0.5	-2.0	-1.4	-0.2	0.7	0.6	-1.7	-0.4	-1.9	-2.2
Schizophrenia (2014)	0.3	0.7	2.1	0.9	-1.5	1.4	-0.3	-0.0	0.2	0.3	-0.5	-1.3	0.3	1.0
Triglycerides	0.8	1.4	5.2	1.3	2.3	0.6	0.9	0.2	-0.2	-0.1	1.9	1.6	0.0	1.1
Type 2 Diabetes (T2D) (2012)	1.5	1.8	7.8	2.8	0.6	1.8	0.1	-0.6	0.3	0.3	0.5	0.3	1.0	2.5
Ulcerative Colitis	0.8	1.2	3.3	1.1	1.5	0.9	0.8	-0.6	0.7	0.2	0.1	1.7	1.8	1.0
Blood Eosinophil Count	0.4	2.7	7.5	-2.3	0.6	-1.3	-0.1	0.4	2.3	2.0	-0.7	0.1	-2.3	-2.7
Blood Platelet Count	0.2	2.6	17.9	0.5	-0.9	-0.5	0.0	4.2	-1.9	-1.0	-0.7	-1.2	-1.0	1.3
Blood Red Count	0.3	3.0	6.6	2.3	-1.9	2.1	0.7	0.2	-1.8	-1.8	0.7	0.7	2.6	2.1
Blood White Count	0.4	3.2	15.1	-1.0	1.5	-1.9	3.9	-2.4	-1.0	-1.1	0.4	1.2	-0.8	-1.6
Heel T-Score	1.2	9.6	23.1	-2.7	-0.5	-2.0	-3.0	2.2	4.7	4.8	-2.6	-3.2	-3.5	-2.5
BMI	0.2	1.4	5.0	-1.1	-1.2	-1.0	0.0	0.9	-0.6	-0.2	-1.3	-1.9	-2.2	-0.8
Height	1.2	23.5	80.5	8.3	-0.6	5.4	-2.2	2.2	-2.8	-1.7	4.1	-1.0	6.4	9.0
Waist Hip Ratio (WHR)	0.0	0.2	0.8	0.9	0.3	-0.0	-0.4	0.4	0.0	0.3	0.1	-0.4	0.3	0.9
Systolic Blood Pressure	0.7	3.7	12.1	-0.4	-1.9	-3.5	-1.5	0.5	-1.8	-1.4	-2.0	-2.3	-2.4	-1.2
Smoking Status	2.2	5.4	13.7	0.8	1.0	1.3	3.7	-3.2	-3.4	-3.7	1.1	2.3	0.7	0.5
Allergy or Eczema	0.9	2.5	8.5	0.7	2.9	-1.2	1.2	1.4	1.2	1.3	2.1	1.9	1.4	0.4
Cardiovascular Disease	0.1	0.4	2.6	-0.7	0.4	-1.6	-0.8	-0.3	-0.1	0.0	-0.4	-0.5	-0.4	-0.6
Hypothyroidism (self reported)	0.3	0.7	3.1	0.5	0.8	0.2	0.3	1.8	-0.6	-0.5	-0.5	0.0	0.8	1.3
Respiratory disease	0.3	0.6	2.6	0.4	1.6	-1.3	-0.0	1.0	0.1	0.2	0.5	0.7	-0.5	0.2
Type 2 Diabetes (T2D) (2018)	0.9	1.7	5.1	1.4	0.5	-1.8	0.9	0.1	-2.3	-1.8	1.3	-0.5	0.7	1.4
Lung FEV1/FVC ratio	0.7	3.7	9.1	0.8	-1.6	3.0	-2.3	0.6	1.9	1.9	-2.7	-2.6	-0.8	0.9
Lung FVC	0.3	1.5	4.4	1.1	0.2	-0.4	2.1	-1.3	-1.5	-1.7	0.8	1.2	1.2	0.2
Neuroticism	0.8	1.9	7.1	2.5	1.2	1.4	-0.5	1.5	0.6	1.0	0.5	-0.2	0.3	2.7
Chronotype (morning person)	0.7	1.7	4.8	0.1	-2.2	0.1	-1.6	2.0	0.8	1.2	-0.8	-2.0	-0.3	-0.3
Hair Pigment	0.0	1.2	4.8	-0.1	-2.2	-0.9	-0.6	-0.0	-1.7	-1.3	-0.7	-1.1	-0.6	-0.4
Tanning	0.2	2.1	4.5	1.3	2.0	-1.4	0.6	-0.2	-1.4	-1.3	2.1	2.1	1.0	1.3
Hand grip strength (left)	0.8	2.1	7.3	1.1	2.7	-0.6	1.8	-1.6	-0.4	-0.3	2.0	1.8	0.7	0.4
Number of treatments/medications taken	0.4	0.7	3.0	-0.2	-0.1	-1.7	-1.1	1.6	-0.8	-0.6	-0.3	0.1	-0.2	0.0
Average weekly spirits intake	2.3	2.9	9.8	-0.8	-2.0	-3.1	-2.6	2.1	-1.0	-0.6	-0.5	-2.0	-0.7	-0.3
Sensitivity / hurt feelings	1.2	2.0	4.8	1.3	-0.9	1.0	-1.0	1.7	1.2	1.6	-1.5	-2.2	-1.2	1.3
Frequency of depressed mood in last 2 weeks	0.7	1.0	3.3	1.6	1.4	-0.1	0.5	1.3	0.4	0.8	0.3	-0.3	0.2	1.8
Hearing difficulty/problems: Yes	0.2	0.4	0.9	-0.6	-0.7	-0.4	0.7	0.7	-1.0	-0.6	-0.6	-0.6	-0.1	-0.1
Relative age of first facial hair	0.6	1.2	4.8	-1.0	-2.2	0.2	-0.7	0.9	-1.2	-1.0	-1.1	-0.6	-0.9	-1.2
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	4.2	1.0	0.4	-1.2	-0.3	2.1	-0.6	-0.2	1.0	-0.2	1.4	1.3
Ever used hormone-replacement therapy (HRT)	0.1	0.2	1.1	0.0	-0.1	-0.0	0.6	1.1	-0.4	-0.3	-0.2	0.1	0.2	-0.0
Ever had hysterectomy (womb removed)	0.4	0.4	1.6	0.5	-0.7	-0.2	-0.0	0.9	0.1	0.3	0.1	-0.5	1.3	1.0
Systolic blood pressure, automated reading	0.9	2.7	8.5	-0.8	-1.4	-2.9	-1.9	1.3	-0.9	-0.5	-2.0	-1.2	-2.2	-1.3
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.1	0.3	0.5	-0.9	0.6	1.0	-0.6	-0.1	0.4	-1.0	0.2	0.5
Angina	0.7	0.9	4.4	0.2	1.5	-0.7	2.1	-0.7	-0.9	-0.9	0.2	0.5	0.6	0.2
Medication for hormone replacement therapy	1.9	2.1	5.4	-1.8	-0.7	-2.3	-0.6	1.5	0.5	1.0	-1.3	-1.6	-1.5	-1.9
Vitamin and mineral supplements	1.2	1.6	6.8	0.3	0.9	2.6	2.1	-1.8	0.2	-0.3	0.2	1.3	0.4	0.5
Supplements: Zinc	0.7	0.8	2.9	-0.8	-1.1	-1.7	-0.2	0.6	-0.9	-0.7	-0.1	-0.2	-0.5	-1.3
Medication: Co-codamol	0.4	0.4	2.7	0.3	0.5	0.7	1.6	0.3	0.1	-0.1	0.3	0.8	0.7	0.1
Medication: Metformin	0.7	1.0	3.2	1.8	0.8	-0.5	0.5	0.4	-1.1	-0.7	0.8	-0.1	1.2	1.7
Diabetes (father)	0.6	0.7	3.3	0.5	0.3	1.8	1.1	-1.1	1.0	0.5	-0.9	0.2	0.0	0.3
Diabetes (mother)	0.4	0.5	2.2	-0.3	0.1	0.0	0.4	-0.7	-1.5	-1.3	0.6	0.2	0.3	0.1
Severe depression (siblings)	1.5	1.7	5.6	-0.2	1.2	-0.9	1.3	-2.4	-1.6	-1.8	1.4	1.0	-0.2	-0.2
Pack years adult smoking proportion	0.7	1.0	4.3	-2.1	-0.1	0.8	1.0	-1.0	0.4	0.3	-0.9	-0.2	-0.7	-1.6
Impedance of leg (right)	0.4	1.8	3.5	1.2	-1.3	0.8	-1.1	1.9	-1.7	-1.4	0.4	-0.9	1.2	1.8
Leg fat-free mass (left)	0.1	0.8	3.9	0.5	-0.2	2.0	-0.8	-0.2	1.0	1.3	0.3	-0.6	0.2	0.7
Trunk fat percentage	0.7	2.9	8.2	-1.3	-2.9	0.8	-1.4	2.6	-0.8	-0.3	-1.6	-2.6	-1.5	-0.6
Hand grip strength (right)	1.0	2.7	7.6	2.2	2.8	0.3	1.5	-1.7	-0.5	-0.3	2.5	1.5	1.3	1.5
Townsend deprivation index at recruitment	0.6	0.8	2.7	0.3	-0.0	1.6	0.3	0.5	-1.7	-1.4	0.4	0.4	0.3	0.7
Current tobacco smoking	1.6	2.7	9.8	-0.1	1.5	0.7	3.1	-2.6	-1.7	-2.0	0.9	1.5	-0.2	-0.4
Average weekly fortified wine intake	0.4	0.4	1.7	-0.1	0.4	1.1	-0.4	-1.3	0.8	0.6	0.7	0.2	-0.1	0.3
Maternal smoking around birth	1.4	2.1	7.9	0.9	-0.7	-0.1	1.3	-0.6	-2.8	-2.6	1.2	0.2	1.6	0.7
Fed-up feelings	1.2	2.2	7.1	1.4	2.7	0.2	1.8	0.3	-0.3	-0.2	2.1	1.8	1.2	1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	2.4	1.1	1.6	-0.3	0.7	-0.2	0.4	0.8	0.4	-0.5	-0.8	1.0
Relative age voice broke	0.9	1.4	4.9	-1.3	-2.2	1.3	-1.1	1.3	0.2	0.3	-1.5	-0.6	-0.9	-1.1
Taking other prescription medications	0.7	1.1	2.7	0.9	0.2	-1.6	0.3	1.2	-1.6	-1.5	0.5	0.7	0.7	0.9
Age when periods started (menarche)	1.1	2.5	11.4	-0.8	-3.4	1.6	-0.3	-1.3	-0.8	-0.9	-2.2	-2.1	-0.1	-0.8
Bilateral oophorectomy (both ovaries removed)	1.3	1.5	7.7	0.4	1.0	0.4	2.8	-0.7	-0.7	-0.9	1.2	1.9	1.0	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	1.0	0.5	-0.0	0.8	0.2	0.6	1.0	0.9	-0.3	-0.2	-0.1	0.5
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	3.0	-0.8	-1.2	0.4	1.6	-1.3	-1.7	-1.7	-0.1	0.0	0.6	-0.6
Qualifications: CSEs or equivalent	0.6	0.8	2.5	0.9	0.2	-1.1	-0.9	1.6	0.5	0.9	1.0	-0.5	-0.6	1.0
Serious illness, injury or assault to yourself	0.1	0.1	0.4	0.2	0.1	-0.7	-0.4	0.4	-0.3	-0.3	-0.0	0.0	0.0	0.5
High blood pressure	0.2	0.4	1.6	0.7	-0.2	0.5	-1.3	0.0	0.5	0.5	-0.5	-0.5	1.0	0.8
Hayfever, allergic rhinitis or eczema	1.0	2.3	7.3	1.6	2.7	-0.8	0.9	1.5	0.9	1.3	2.1	1.3	1.2	1.2
Multivitamins +/- minerals	0.6	0.7	2.9	0.0	-0.4	-1.5	-1.3	1.7	0.3	0.6	-0.1	-0.8	0.3	0.0
Stomach or abdominal pain in last month	0.9	1.1	7.0	-0.1	1.3	-2.6	-0.0	1.8	0.0	0.3	0.4	0.4	-0.2	-0.1
Supplements: Glucosamine	1.7	2.2	5.6	-1.1	-0.6	-1.7	-2.2	2.4	1.2	1.7	-0.7	-1.2	-0.8	-1.5
Diverticular disease/diverticulitis (self-reported)	0.7	0.9	2.8	-1.4	-0.4	-0.8	0.4	-0.2	-0.0	-0.1	-1.4	-0.6	-1.7	-1.2
Medication: Atenolol	0.2	0.3	0.7	-0.3	-0.5	-0.8	-0.1	-0.7	-0.3	-0.4	-0.7	-0.6	-0.5	-0.6
Medication: Levothyroxine sodium	0.5	0.9	3.6	-0.0	1.1	-1.9	-0.4	1.9	0.4	0.7	-0.3	-0.4	0.2	0.6
Sitting height	0.6	4.0	11.5	3.2	-0.1	2.4	-2.4	0.7	-0.0	0.5	2.0	-0.6	2.4	3.4
Chronic bronchitis/emphysema (father)	0.4	0.5	2.7	0.1	1.6	0.5	0.9	-0.3	0.7	0.4	-0.4	0.9	-0.3	-0.2
High blood pressure (mother)	0.5	0.7	2.5	1.5	-0.4	0.5	-0.3	0.3	-1.1	-0.8	-0.1	-0.4	0.7	1.6
Body mass index (BMI)	0.3	1.3	3.0	-1.6	-0.9	-0.4	-0.2	1.6	0.6	0.9	-1.2	-1.1	-1.7	-1.3
Impedance of leg (left)	0.5	2.5	5.9	1.6	-1.3	0.7	-0.6	2.0	-2.4	-2.1	0.8	-0.7	1.4	2.2
Leg predicted mass (left)	0.1	0.8	3.7	0.4	-0.1	1.9	-0.8	-0.2	1.0	1.3	0.4	-0.6	0.3	0.7
Trunk fat mass	0.5	2.1	6.0	-0.6	-2.4	1.1	-1.4	2.3	-0.7	-0.1	-1.1	-2.3	-0.9	0.1
Waist circumference	0.3	1.2	3.7	-0.3	-1.6	0.6	-1.1	1.9	0.2	0.7	-1.0	-1.6	-0.9	0.0
Number of incorrect matches in round	0.6	1.1	4.6	0.9	-0.4	1.7	1.2	-2.1	-0.6	-0.9	0.2	0.3	0.5	0.4
Past tobacco smoking	0.9	1.7	5.4	-0.0	-0.2	0.5	-2.0	0.9	2.3	2.3	-0.5	-1.4	-0.9	0.2
Alcohol usually taken with meals	0.9	1.5	5.0	-0.7	-0.2	-0.2	-0.9	-0.9	2.2	2.1	-0.7	-0.7	-1.5	-1.5
Nervous feelings	0.9	1.7	6.0	2.4	-0.3	2.0	-0.0	1.2	-0.4	-0.1	-0.2	-1.0	0.9	2.3
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.5	1.9	0.6	1.3	0.2	1.4	-0.4	0.8	0.8	0.2	-0.4	-0.5	-0.0
Hearing difficulty/problems with background noise	0.7	1.0	2.5	-1.6	-0.9	-1.2	0.8	-0.2	-1.3	-1.0	-1.1	-0.2	-0.9	-1.1
Hair/balding pattern: Pattern 2	0.2	0.3	1.9	-0.2	-0.2	0.3	0.4	-1.4	0.3	0.2	0.8	0.4	-0.0	-0.5
Had menopause	1.1	1.3	4.6	-1.1	-1.0	-1.2	-0.7	1.5	-0.5	0.2	-0.9	-2.1	-1.3	-1.0
Had other major operations	1.1	1.4	5.2	1.5	0.6	-1.0	-1.1	2.3	0.2	0.5	0.4	-0.3	0.8	1.9
Forced vital capacity (FVC)	1.3	4.8	15.7	4.0	1.2	0.7	0.7	-1.2	-1.8	-1.6	2.8	0.9	2.8	3.3
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	2.1	-0.2	-0.5	0.1	-0.4	1.4	0.6	0.5	-0.4	-0.4	-0.2	0.1
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.9	-0.1	0.7	-0.2	0.9	-0.6	0.5	0.6	0.5	-0.5	0.2	-0.1
Qualifications: None of the above	0.6	1.3	6.0	-0.4	0.2	1.6	2.5	-1.1	-1.2	-1.3	-0.5	0.9	-0.6	-0.5
Financial difficulties in last 2 years	0.4	0.5	2.7	0.2	0.8	-0.6	1.6	0.5	-0.5	-0.4	0.8	-0.2	-0.3	0.2
Mouth/teeth dental problems	2.1	3.2	6.8	0.6	2.4	1.6	1.9	-2.5	-0.5	-1.0	2.3	2.6	1.7	0.5
Heart attack	0.2	0.2	0.5	0.7	0.6	0.2	0.4	-0.2	0.6	0.7	-0.2	-0.3	-0.1	0.5
Allergy	0.8	1.8	6.0	-1.4	-2.5	0.1	-1.1	-1.2	-0.7	-0.9	-1.6	-1.5	-1.3	-1.0
Pain all over the body in last month	0.9	1.0	2.7	0.6	1.3	1.6	0.3	-1.5	1.1	0.9	0.4	0.5	0.8	0.7
Diabetes (self-reported)	1.0	1.6	4.9	2.2	0.7	-1.5	-0.3	0.9	-1.0	-0.3	1.5	-0.9	0.7	2.1
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	3.0	-0.4	1.7	-0.6	1.1	0.7	1.1	0.9	1.1	1.7	0.3	-0.4
Medication: Ramipril	0.2	0.2	1.2	0.2	0.6	-0.3	0.2	-1.1	-0.4	-0.2	0.5	-0.6	-0.4	-0.0
Medication: Simvastatin	0.7	1.0	2.3	-1.1	-1.2	-0.5	0.1	0.7	-0.4	-0.3	-1.4	-1.5	-1.1	-1.2
Fluid intelligence score	0.6	1.2	4.0	1.0	-1.0	-0.2	-2.0	0.6	1.0	1.2	-0.3	-1.9	0.4	0.7
Illnesses of siblings	0.6	0.9	2.4	1.4	0.1	1.5	-0.3	-0.6	-0.3	-0.4	1.5	0.5	1.1	0.9
Neuroticism score	0.7	1.4	5.7	2.1	0.8	1.4	0.4	1.3	-0.1	0.3	0.1	-0.5	0.2	2.4
Weight	0.2	1.0	2.6	0.8	-1.1	1.6	-0.8	1.3	0.1	0.6	0.1	-1.4	0.2	1.2
Impedance of arm (right)	0.3	1.3	3.9	0.1	-1.9	0.4	-1.9	0.4	-1.0	-0.9	-0.8	-2.0	-0.0	0.2
Arm fat percentage (right)	0.6	2.2	5.0	-1.7	-2.2	-0.1	-0.9	1.9	0.0	0.3	-1.7	-1.9	-1.8	-1.3
Trunk fat-free mass	0.4	2.3	6.9	2.4	0.6	2.1	-0.2	-0.1	0.1	0.6	1.9	0.3	1.9	2.6
Hip circumference	0.2	1.0	2.7	-0.2	-1.6	1.1	-0.9	1.6	-0.4	0.1	-0.8	-1.4	-1.2	0.1
Time employed in main current job	1.3	1.5	6.0	-0.6	-0.9	-0.4	-2.5	0.5	1.0	1.3	-1.5	-1.5	-1.1	-0.8
Alcohol intake versus 10 years previously	0.4	0.7	1.9	0.1	0.6	0.6	-0.5	1.1	1.3	1.4	0.2	0.2	0.8	0.8
Father’s age at death	0.5	0.7	1.7	0.7	0.6	0.4	-0.7	1.3	1.2	1.2	0.5	0.1	0.1	0.9
Worrier / anxious feelings	1.0	1.9	5.7	0.6	-1.2	2.3	-0.6	1.5	0.6	0.8	-2.4	-1.9	-0.6	1.0
Frequency of tiredness / lethargy in last 2 weeks	1.2	2.0	5.3	2.1	2.0	-0.6	0.2	2.1	0.5	1.1	1.2	-0.7	0.3	2.3
Falls in the last year	0.4	0.6	2.4	-0.9	0.2	-1.5	0.6	0.7	-0.5	-0.3	-0.0	0.2	-1.2	-0.8
Hair/balding pattern: Pattern 3	0.9	1.4	3.8	-1.4	0.7	-1.3	1.5	-1.4	-0.6	-0.8	0.1	1.0	-0.7	-1.9
Number of live births	0.4	0.5	1.8	-0.5	-0.4	-1.3	0.3	0.4	-1.0	-0.7	-0.7	-0.2	-1.0	-0.2
Forced expiratory volume in 1-second (FEV1)	0.9	3.0	11.6	3.4	0.7	1.2	0.2	-0.9	-1.0	-0.8	2.0	0.3	2.2	2.9
Pulse rate	1.0	1.6	3.9	-1.6	1.6	-1.3	0.3	0.9	1.5	1.3	1.1	2.0	0.3	-1.0
Happiness	0.3	0.4	1.0	0.3	-0.5	0.0	-0.3	0.8	0.8	1.0	-0.6	-1.0	0.5	0.0
Noisy workplace	1.2	1.4	3.6	-1.8	0.1	-1.0	1.9	-0.8	-1.4	-1.4	-0.6	-0.4	-0.9	-1.5
Qualifications: A levels/AS levels or equivalent	1.3	3.0	10.0	0.3	-0.6	-0.5	-2.7	0.9	2.7	3.2	-0.9	-2.3	-0.1	-0.0
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.2	2.1	-0.2	1.1	-1.3	-0.6	1.0	1.4	1.5	1.3	1.2	1.2	0.1
Mouth/teeth dental problems: Dentures	1.1	1.9	5.1	-0.8	-2.1	-0.4	-0.6	2.0	-0.4	0.0	-2.2	-1.6	-1.7	-0.7
Asthma	0.5	1.0	4.2	0.5	2.0	-1.5	0.6	0.7	-0.5	-0.4	0.7	1.3	-0.6	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.1	1.4	-1.1	1.4	-0.5	0.2	-0.6	-0.3	0.2	-0.9	1.3	1.4
Medication: Cholesterol lowering	0.5	0.8	5.1	-0.3	-0.6	-2.3	-0.5	1.0	-0.7	-0.4	0.2	-0.9	-0.2	-0.2
Depression (self-reported)	0.5	0.6	1.8	-0.3	-0.1	-0.4	1.4	-0.8	0.0	0.1	-0.9	-1.0	-1.1	-0.9
Medication: Lansoprazole	0.8	0.9	4.1	0.7	1.3	-0.0	2.0	1.0	-0.4	-0.4	0.5	0.6	1.2	0.6
Prospective memory result	1.9	2.4	6.7	-0.2	1.1	1.8	2.5	-2.6	-0.9	-1.4	0.4	1.8	1.6	0.4
Lung cancer (father)	1.0	1.2	2.4	-0.9	-0.6	-1.2	-1.0	1.5	-1.4	-1.0	-1.0	-0.7	-1.6	-0.6
Illnesses of mother	0.5	0.6	1.8	0.0	0.5	1.2	-0.4	-1.4	1.2	0.8	0.1	0.6	-0.4	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.9	10.2	3.2	0.5	2.2	0.5	-0.9	-0.6	-0.5	1.6	0.9	2.1	2.6
Pulse wave Arterial Stiffness index	0.5	0.6	2.1	-1.5	-0.5	-0.8	-0.3	-0.8	-0.3	-0.2	-0.2	0.2	-0.9	-1.3
Impedance of arm (left)	0.3	1.4	4.4	0.4	-1.7	0.5	-2.0	0.4	-1.2	-1.0	-0.8	-2.1	-0.1	0.5
Arm fat mass (right)	0.3	1.2	2.9	-0.9	-1.7	0.9	-0.7	1.4	-0.0	0.3	-1.2	-1.6	-1.2	-0.5
Trunk predicted mass	0.4	2.3	6.9	2.4	0.7	2.2	-0.1	-0.2	0.1	0.6	1.9	0.4	1.9	2.6
Standing height	0.9	9.0	26.7	4.8	-0.3	4.4	-1.4	-0.4	-1.2	-0.5	2.7	-0.6	4.2	5.2
Length of working week for main job	0.3	0.4	0.9	-0.5	0.6	0.6	0.9	-0.0	0.8	0.8	0.9	0.3	-0.4	-0.2
Exposure to tobacco smoke at home	0.7	0.8	2.8	0.3	0.5	0.7	-0.3	0.5	0.4	0.3	1.6	0.8	1.7	1.0
Breastfed as a baby	0.4	0.5	2.5	-0.3	-0.6	-0.6	-1.6	0.3	0.6	0.8	0.2	-0.8	-0.2	-0.3
Tense / ‘highly strung’	0.2	0.3	0.7	-0.6	-0.6	0.2	0.3	0.2	0.5	0.5	-0.9	-0.3	-0.6	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	2.7	0.6	0.2	-0.0	-0.8	1.6	1.0	1.6	-0.0	-1.5	0.1	0.6
Hair/balding pattern: Pattern 4	0.9	2.3	6.1	1.7	-0.1	1.6	-2.5	1.9	1.0	1.3	-0.6	-1.8	0.6	1.9
Birth weight of first child	0.4	0.8	6.7	-0.1	0.0	0.0	-0.4	2.6	-0.0	0.4	0.6	-0.6	0.6	0.5
Peak expiratory flow (PEF)	1.2	2.7	10.5	3.2	0.8	0.4	-0.2	0.3	-0.7	-0.3	1.9	-0.7	2.1	3.0
Pulse wave reflection index	0.3	0.4	1.3	-0.3	-1.1	-0.1	-0.5	0.5	-0.2	0.1	-1.1	-0.7	-0.6	-0.5
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.9	-0.3	1.0	-1.4	1.3	-1.1	-0.5	-0.3	1.1	0.1	-0.2	-0.6
Loud music exposure frequency	0.5	0.5	1.3	-0.8	0.6	-0.7	-1.0	0.1	0.3	0.6	-0.5	-0.8	-1.1	-0.7
Qualifications: O levels/GCSEs or equivalent	1.5	2.3	7.2	-0.2	-0.2	-0.4	-2.0	1.1	2.6	2.7	-1.2	-1.7	-1.4	-0.3
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	3.4	0.9	-1.5	-0.9	-1.8	1.4	-0.7	-0.3	0.1	-1.2	0.1	0.9
Blood clot in the leg (DVT)	1.3	1.6	6.8	0.9	0.8	1.7	0.7	-0.2	1.0	0.9	1.5	0.8	2.6	1.4
Medication: Paracetamol	0.8	1.4	4.8	1.4	0.7	0.5	-0.2	2.2	-0.4	-0.1	1.1	0.6	1.4	2.0
Headache pain in last month	2.2	3.9	13.8	1.9	3.7	-2.0	1.5	1.0	0.0	0.5	2.9	1.7	1.6	1.8
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	7.6	1.2	0.2	2.8	0.4	0.1	0.2	0.1	0.2	0.6	0.8	1.3
Glaucoma (self-reported)	0.8	0.9	2.8	1.3	-0.5	1.7	-0.5	1.2	-0.1	0.2	0.2	-1.1	0.8	1.4
Gout (self-reported)	1.1	1.5	5.7	0.2	-1.3	0.7	1.3	0.2	-2.3	-2.4	-0.9	0.0	-0.6	0.3
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	3.3	0.8	0.4	-0.6	-0.0	1.8	-0.6	-0.4	-0.8	-0.6	0.7	1.4
Medication: Amlodipine	1.8	2.6	8.6	-0.1	-2.3	0.8	-2.1	0.1	0.7	1.1	-2.4	-2.9	-1.1	0.6
Medication: Ventolin 100micrograms inhaler	1.0	1.3	4.9	-0.7	0.6	-2.2	0.7	-0.3	-1.5	-1.6	-0.1	0.7	-1.3	-1.1
Birth weight	2.0	4.3	10.7	1.2	3.2	-0.5	1.9	-2.6	-0.8	-1.1	3.3	2.6	2.4	0.9
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.9	-0.9	-0.1	0.1	0.2	-0.5	-0.1	-0.3	0.3	0.7	0.5	-0.6
High blood pressure (siblings)	1.1	1.6	5.8	-0.9	-0.3	-2.0	0.1	0.5	-0.6	-0.4	-2.2	-0.8	-2.4	-0.7
Forced vital capacity (FVC), Best measure	1.1	4.1	12.0	3.5	0.8	1.6	1.0	-1.4	-1.8	-1.7	2.2	1.5	2.5	2.9
Body fat percentage	0.7	2.6	7.1	-1.5	-2.7	0.3	-1.1	2.7	-0.7	-0.2	-1.6	-2.2	-1.6	-0.8
Leg fat percentage (right)	0.6	2.2	7.3	-1.3	-2.3	0.0	-0.7	2.7	-0.3	0.1	-1.7	-1.9	-1.4	-0.7
Arm fat-free mass (right)	0.3	1.5	4.7	1.7	0.3	2.2	-0.2	0.6	-0.0	0.5	1.5	0.4	1.3	2.1
Exposure to tobacco smoke outside home	0.9	1.2	4.8	-0.8	0.3	-2.0	-1.1	0.2	0.4	0.4	-0.2	-0.8	-2.2	-1.1
Comparative body size at age 10	1.0	2.6	17.0	0.5	1.1	2.1	2.1	-4.1	0.8	0.5	0.2	0.8	-0.1	-0.3
Number of full brothers	0.4	0.6	2.0	0.0	-0.9	0.7	0.0	0.0	-1.1	-1.1	-1.4	-0.5	0.2	0.4
Worry too long after embarrassment	1.0	1.7	7.0	2.2	0.2	1.3	0.5	1.0	-1.1	-0.7	-0.9	-0.8	0.5	2.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	2.4	1.1	1.5	-0.3	0.9	-0.0	-0.3	-0.0	1.2	0.4	-0.0	0.8
Wheeze or whistling in the chest in last year	1.0	1.8	6.4	-2.5	0.7	-1.2	1.3	-1.1	-0.4	-0.4	0.4	1.0	-0.9	-2.5
Number of children fathered	1.7	1.9	7.8	-1.7	1.1	-2.8	1.2	1.0	-0.1	-0.2	0.9	1.7	-0.3	-1.7
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	2.9	0.4	1.7	-0.4	1.4	-1.3	-0.6	-0.7	1.6	1.2	0.8	0.0
Age at first live birth	0.6	1.1	5.6	-0.5	-0.9	-0.6	-2.4	0.9	0.4	0.6	-0.3	-1.6	-1.2	-0.2
Pulse wave peak to peak time	0.8	0.9	3.4	1.8	0.5	1.2	0.0	0.8	0.3	0.3	0.4	-0.3	1.1	1.7
Health satisfaction	0.9	1.1	4.5	-1.1	0.5	-0.4	1.1	-2.1	-1.1	-1.1	0.3	0.9	-0.7	-1.1
Shortness of breath walking on level ground	0.6	0.7	2.4	-0.7	-0.1	1.0	1.6	-0.3	-1.0	-1.0	-0.8	0.4	-0.6	-0.3
Qualifications: College or University degree	0.4	1.2	6.2	1.2	-0.4	-0.0	-2.5	0.4	1.0	1.1	-0.1	-0.8	1.5	0.9
Eye problems/disorders: None of the above	1.0	1.2	3.3	1.1	1.1	0.6	-0.8	0.0	1.3	1.1	1.8	0.8	1.0	1.2
Mouth/teeth dental problems: Loose teeth	0.8	0.9	2.3	-0.9	-1.0	-0.2	-0.2	-0.0	1.5	1.5	-1.0	-1.2	-0.6	-1.0
Emphysema/chronic bronchitis	0.5	0.6	1.7	0.4	-0.4	1.3	1.0	-1.3	-0.6	-0.6	-0.2	0.3	0.8	0.1
Medication for pain relief, constipation, heartburn	1.3	2.2	6.0	-2.2	-0.0	-1.4	-0.3	-1.0	1.4	1.0	-1.5	-0.3	-2.3	-2.5
Neck or shoulder pain in last month	1.0	1.4	2.4	0.9	1.5	-1.6	1.4	0.1	-1.3	-1.2	1.4	0.7	1.2	0.6
Medication: Blood pressure	0.4	0.7	2.3	-0.7	-0.7	-1.5	-0.9	-0.6	-0.1	-0.1	-0.9	-0.9	-0.9	-0.7
Angina (self-reported)	0.5	0.7	3.4	0.1	1.5	-0.9	1.8	-0.2	-0.6	-0.6	0.1	0.3	0.5	0.1
Migraine (self-reported)	2.1	2.6	6.3	1.5	2.5	1.6	0.1	-0.4	2.1	1.8	1.3	2.1	1.4	1.6
Medication: Ibuprofen	0.8	1.0	2.0	1.4	-1.0	0.3	0.1	0.4	-1.4	-1.1	0.5	-0.7	1.3	1.4
Medication: Allopurinol	1.0	1.3	4.3	0.4	-0.8	1.0	1.3	-0.2	-2.0	-2.1	-1.1	-0.3	-0.9	0.5
Medication: Omeprazole	0.4	0.5	1.8	-0.2	0.8	0.5	0.7	-1.3	0.2	-0.1	0.4	1.2	0.7	0.1
Medication: Seretide 50 evohaler	1.2	1.4	3.3	1.6	0.1	1.6	1.4	-0.7	-1.8	-1.7	-0.3	-0.0	-0.3	1.4
Mean time to correctly identify matches	1.9	3.6	9.1	-2.1	2.2	-0.3	2.4	-2.8	1.1	0.3	0.8	3.0	0.3	-2.4
Heart disease (mother)	0.7	0.9	3.0	-1.4	0.1	-1.7	1.0	-0.0	-0.4	-0.4	-0.3	-0.3	-0.5	-1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	1.3	0.1	1.1	-0.7	-0.3	0.3	0.3	0.4	0.3	0.4	0.2	-0.1
Whole body fat mass	0.3	1.4	4.6	-0.6	-2.0	0.8	-1.0	2.2	-0.7	-0.1	-0.8	-1.8	-0.8	0.1
Leg fat mass (right)	0.3	1.1	3.1	-0.9	-1.8	0.8	-0.5	1.7	-0.3	0.1	-1.1	-1.5	-0.9	-0.3
Arm predicted mass (right)	0.3	1.3	4.5	1.6	0.3	2.1	-0.2	0.4	-0.1	0.3	1.5	0.6	1.2	1.8
Pulse rate, automated reading	0.2	0.7	2.8	-1.1	0.4	-1.5	-0.1	1.7	-0.4	-0.3	0.2	0.6	-0.6	-0.8
Alcohol intake frequency.	1.0	2.4	7.9	-1.4	-0.1	-0.9	-0.7	1.5	2.5	2.8	-1.4	-1.3	-1.1	-1.2
Comparative height size at age 10	1.4	7.9	25.8	4.9	0.4	2.4	-2.0	0.7	-2.0	-1.2	3.0	-0.3	3.6	5.1
Number of full sisters	0.2	0.3	1.2	0.1	-0.0	0.4	1.1	0.1	-0.9	-0.6	-0.4	-0.3	0.0	0.6
Suffer from ‘nerves’	0.5	0.8	1.8	1.3	0.9	-0.6	0.9	0.8	-1.2	-0.7	0.3	-0.6	-0.4	1.2
Overall health rating	0.5	1.2	5.3	-0.2	-0.1	-0.7	1.4	-0.5	-2.3	-2.1	-0.0	0.1	0.0	0.1
Chest pain or discomfort	0.8	1.2	3.4	-0.8	0.6	-0.8	1.2	1.1	-0.5	-0.6	1.9	1.7	1.2	-0.6
Had major operations	0.7	0.8	4.6	-0.1	-0.9	0.6	1.5	0.3	-0.7	-0.4	-0.5	-2.1	-0.0	0.1
Age at last live birth	0.7	1.0	3.2	1.0	-0.1	-1.8	-1.7	0.7	-0.7	-0.2	0.7	-1.0	-0.6	1.1
Family relationship satisfaction	0.3	0.3	0.8	-0.5	0.3	0.7	0.9	-0.6	0.0	-0.1	-0.3	0.8	0.7	-0.6
Leg pain on walking	0.3	0.4	1.6	-0.4	0.6	0.2	-0.2	-0.2	0.6	0.9	-0.0	-1.2	-0.7	-0.3
Qualifications: NVQ or HND or HNC or equivalent	1.7	2.0	4.3	-1.6	1.5	-1.1	1.7	-1.4	0.6	0.3	1.8	2.1	-0.5	-1.9
Commuting to job workplace: Car/motor vehicle	1.5	1.7	4.3	-0.6	-1.8	-2.1	-0.5	0.1	-1.5	-1.3	-0.9	-1.6	-1.6	-0.9
Illness, injury, bereavement, stress in last 2 years	1.5	1.9	4.4	-1.9	0.0	0.8	-1.0	-1.1	2.0	1.6	-1.4	0.2	-1.0	-2.1
Medication: Aspirin	0.6	0.7	4.3	0.0	-0.4	-1.3	-1.0	2.1	-0.3	0.3	-0.2	-0.9	-0.1	-0.2
Supplements: Vitamin C	0.4	0.5	2.6	0.3	-0.5	-0.9	-1.6	0.1	0.4	0.5	0.6	-0.4	-0.4	-0.4
Knee pain experienced in last month	1.2	1.8	6.1	0.5	2.1	-0.9	0.6	0.3	1.4	1.4	2.5	1.6	1.5	0.3
Hypertension (Self-reported)	0.2	0.4	2.0	0.7	-0.4	-0.2	-1.4	0.2	0.3	0.3	-0.5	-0.7	0.8	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.6	3.2	1.4	-0.4	1.8	0.4	-0.4	-1.6	-1.6	0.2	0.5	1.7	1.8
Illnesses of father: Heart disease	1.5	2.1	8.3	0.5	-2.4	-0.8	-0.7	0.7	-1.5	-1.1	-1.8	-2.9	-0.8	0.3
Illnesses of siblings: Diabetes	0.4	0.5	1.8	0.2	1.3	0.6	1.1	0.3	0.3	0.2	0.1	0.8	0.7	0.6
Smoking status: Previous	0.6	0.9	3.8	-0.1	-0.9	-0.5	1.0	0.1	-1.9	-1.8	0.3	0.8	0.4	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.6	4.2	1.8	0.3	1.5	0.2	0.1	-0.7	-0.4	2.0	0.3	1.7	2.0
Whole body fat-free mass	0.2	1.4	4.4	1.7	0.4	2.1	-0.4	0.0	0.4	0.8	1.4	0.0	1.2	1.9
Leg fat-free mass (right)	0.1	0.7	3.1	0.7	0.1	1.8	-0.7	-0.3	0.8	1.2	0.6	-0.4	0.4	0.9
Arm fat percentage (left)	0.5	2.2	4.5	-1.5	-2.1	-0.1	-1.2	1.9	-0.0	0.3	-1.7	-2.0	-1.9	-1.1
Average weekly red wine intake	1.5	2.2	5.0	-2.0	-1.3	-1.5	-0.8	-1.4	0.8	0.8	-0.5	-1.9	-1.7	-2.2
Handedness (chirality/laterality): Left-handed	0.3	0.3	1.4	0.5	1.2	0.4	0.9	0.2	0.3	0.2	0.5	0.4	-0.1	0.3
Mood swings	0.8	1.5	5.8	1.2	1.0	-0.8	1.3	2.4	-1.3	-0.6	1.2	-0.4	0.1	1.5
Loneliness, isolation	1.1	1.5	5.0	1.0	2.2	1.7	1.3	-1.5	0.4	0.3	0.6	1.7	-0.2	0.8
Long-standing illness, disability or infirmity	0.4	0.6	3.1	-0.5	1.5	-1.8	0.8	0.1	0.5	0.5	0.3	0.3	-0.0	-0.3
Ever had bowel cancer screening	2.2	2.5	9.3	0.1	-3.1	-1.1	-0.8	2.0	-2.4	-1.8	-0.6	-1.8	-0.3	0.0
Diabetes diagnosed by doctor	1.0	1.6	5.3	2.3	0.7	-1.9	-0.4	0.5	-1.3	-0.7	1.2	-0.7	0.3	2.0
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	1.1	0.3	0.1	-0.4	0.6	0.1	-0.8	-0.5	1.1	0.0	0.1	-0.1
Friendships satisfaction	0.3	0.3	0.8	-0.7	0.3	-0.9	0.7	-0.6	0.6	0.7	-0.2	-0.3	0.0	-0.7
Qualifications: nursing, teaching	0.6	0.9	2.3	-0.9	-1.0	-1.1	-1.4	0.1	1.0	0.7	-1.5	-0.3	-0.8	-0.9
Commuting to job workplace: Walk	1.3	1.4	3.2	1.6	1.6	0.4	0.3	-0.6	-0.1	-0.3	1.8	1.4	1.3	1.6
Eye problems/disorders: Cataract	1.6	1.9	3.6	-1.1	-0.5	-1.9	1.6	-0.6	-1.9	-1.8	-0.8	0.3	-1.3	-1.9
Mouth/teeth dental problems: Mouth ulcers	1.2	1.9	5.4	0.4	-1.0	-1.8	-2.3	1.8	0.8	1.2	-1.2	-2.0	-1.0	0.4
Medication for cholesterol	0.5	0.8	3.5	0.4	0.6	1.0	1.0	-1.9	-0.5	-0.7	0.7	0.5	0.6	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	3.2	0.6	1.4	0.4	1.8	-0.7	0.5	0.5	0.5	1.0	1.0	0.6
Back pain experienced in last month	0.2	0.3	0.7	-0.5	0.4	-0.9	0.3	0.7	0.5	0.7	-0.3	-0.2	-0.8	-0.3
Mineral and other dietary supplements	0.8	1.1	4.6	0.5	-0.2	2.0	0.9	-2.1	0.5	0.2	-0.6	-0.6	-0.8	0.4
Breast cancer (self-reported)	0.5	0.6	1.8	0.9	-0.6	-0.9	-0.7	1.3	-0.9	-0.7	0.7	-0.6	0.0	0.7
Asthma (self-reported)	0.5	1.0	3.8	0.6	1.9	-1.6	0.5	1.1	-0.4	-0.2	0.6	1.2	-0.8	0.1
Osteoporosis (self-reported)	0.5	0.6	2.2	-0.5	-0.2	0.5	0.1	-1.0	1.0	0.8	-1.5	-0.3	-0.8	-0.8
Osteoarthritis (self-reported)	1.1	1.5	4.0	1.1	0.2	1.9	2.0	-1.1	-0.7	-0.9	0.7	0.7	1.6	1.1
Medication: Aspirin	0.7	0.9	5.5	0.1	-0.5	-1.2	-1.2	2.3	-0.2	0.3	-0.2	-0.9	-0.1	-0.0
Medication: Gliclazide	2.4	2.7	7.1	2.3	2.2	-0.2	1.0	-1.1	-1.7	-1.5	2.7	1.1	0.9	1.7
Illnesses of father: None of the above (group 1)	0.6	0.8	2.6	-0.8	1.1	-1.3	-0.2	-0.0	0.1	0.1	1.4	1.6	-0.3	-0.4
Smoking status: Current	2.2	3.5	11.3	0.4	1.9	1.2	3.4	-2.9	-1.6	-2.1	1.3	2.1	0.6	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.7	1.3	-0.7	0.8	0.6	0.5	-0.5	-0.4	-0.4	-0.5	0.3	1.1
Whole body water mass	0.2	1.4	4.6	1.6	0.3	2.1	-0.4	-0.0	0.4	0.8	1.4	0.1	1.2	1.8
Leg predicted mass (right)	0.1	0.7	3.0	0.7	0.2	1.7	-0.6	-0.3	0.9	1.2	0.6	-0.3	0.3	0.8
Arm fat mass (left)	0.2	0.9	2.1	-0.7	-1.5	0.7	-0.6	1.4	-0.4	-0.0	-0.9	-1.4	-1.0	-0.2
Number of self-reported non-cancer illnesses	0.7	1.2	4.8	-0.7	2.2	-0.9	1.0	0.0	0.8	0.5	0.5	2.0	0.6	-0.6
Average weekly champagne plus white wine intake	2.0	2.7	5.9	-1.6	-0.4	-2.2	-1.8	1.2	1.3	1.4	-1.8	-0.6	-2.4	-2.2
Miserableness	2.1	3.7	8.3	2.9	2.2	0.4	1.6	-0.4	-1.6	-1.4	2.5	0.9	2.2	2.9
Guilty feelings	1.0	1.6	5.9	2.4	1.4	-0.3	1.2	0.9	-0.9	-0.4	0.8	-0.6	0.2	2.2
Wears glasses or contact lenses	4.1	4.7	8.3	-2.4	-1.6	-2.7	-1.9	1.6	1.1	1.7	-2.0	-2.8	-2.9	-2.4
Ever taken oral contraceptive pill	0.9	1.0	5.0	0.1	-0.6	0.0	0.8	-1.0	-2.2	-2.0	0.1	-0.5	-0.1	-0.1
Hearing aid user	0.2	0.3	0.8	-0.2	0.4	-0.6	-0.1	0.3	-0.7	-0.8	0.3	0.9	0.7	0.1
Mother’s age at death	1.1	1.4	4.3	1.0	0.4	0.2	1.8	-0.1	-1.9	-2.1	0.5	1.0	1.1	0.7
Financial situation satisfaction	0.7	0.9	1.9	-1.0	-0.2	-1.4	0.6	-1.4	-0.8	-0.7	-0.3	-0.7	-1.2	-1.0
Tinnitus: Yes, now most or all of the time	1.2	1.4	4.5	0.5	1.6	-0.1	1.9	-1.4	-0.7	-1.1	0.8	2.1	0.6	0.6
Commuting to job workplace: Public transport	3.2	3.8	7.5	2.0	2.5	1.9	0.8	-1.2	1.2	0.9	2.3	2.1	2.7	2.6
Eye problems/disorders: Glaucoma	0.7	0.9	2.7	1.2	-0.2	0.8	-0.6	1.7	0.7	1.0	-0.2	-1.2	0.5	1.3
Medication: Blood pressure	0.5	0.9	2.5	1.3	-0.6	1.4	-0.7	0.8	-0.1	-0.0	-0.2	-0.1	1.6	1.4
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.8	-0.2	0.3	0.1	-0.4	0.2	0.8	0.9	-0.5	0.1	0.2	-0.2
Supplements: Fish oil (including cod liver oil)	0.9	1.1	2.5	-0.2	0.5	-1.3	0.2	1.6	-1.4	-1.3	0.9	1.4	1.2	0.2
High cholesterol (Self-reported)	1.1	1.9	4.7	-2.2	0.2	-1.8	-0.4	1.2	1.4	1.7	-0.8	-0.2	-1.4	-2.1
Medication: Bendroflumethiazide	0.2	0.3	1.2	0.9	-0.2	-0.5	0.1	0.6	-0.1	-0.1	0.1	-0.3	1.1	0.9
Medication: Paracetamol	0.7	1.1	7.1	0.9	0.5	-0.6	-0.9	2.7	-0.5	0.0	0.5	-0.5	0.0	1.3
Medication: Lisinopril	0.8	1.1	2.4	1.2	0.6	1.0	-1.0	1.1	1.1	1.1	0.8	0.3	1.0	1.5
Medication: Atorvastatin	1.9	2.3	14.1	0.1	2.0	-3.8	0.4	1.4	0.5	0.8	1.9	0.6	0.7	0.5
Illnesses of father: High blood pressure	1.1	1.4	3.2	1.8	-0.7	1.5	-1.6	-0.3	-0.2	-0.3	0.5	-0.2	1.6	1.8
Alcohol drinker status: Never	0.1	0.1	0.2	-0.1	-0.3	0.1	0.5	0.2	-0.4	-0.2	-0.5	-0.1	-0.2	0.2
Ever smoked	0.8	1.3	3.2	-0.5	0.8	-1.1	1.8	-1.0	-1.7	-1.7	0.2	1.3	0.1	-1.0
Basal metabolic rate	0.2	1.1	4.3	1.4	0.0	2.1	-0.5	0.3	0.4	0.8	1.0	-0.3	0.9	1.7
Leg fat percentage (left)	0.6	2.2	8.1	-0.9	-2.4	-0.1	-0.5	2.9	-0.7	-0.2	-1.6	-1.9	-1.4	-0.3
Arm fat-free mass (left)	0.3	1.5	4.2	1.6	0.5	2.1	0.3	0.5	0.1	0.5	1.8	0.6	1.4	1.9
Number of operations (self-reported)	0.5	0.8	2.2	0.6	0.8	-0.2	1.1	1.2	-0.5	-0.2	0.5	-0.9	1.2	1.5
Average weekly beer plus cider intake	1.1	1.6	3.7	-1.8	0.9	-1.8	1.7	-1.9	-0.5	-0.6	0.2	0.1	-0.6	-1.8
Irritability	0.6	1.1	2.5	-1.0	0.1	-0.4	-1.5	0.9	1.6	1.6	-0.1	-0.4	-1.5	-0.5
Risk taking	0.5	0.7	2.0	-0.0	-0.3	-0.2	0.7	1.3	-1.4	-1.3	0.9	0.4	0.8	0.2
Ever had prostate specific antigen (PSA) test	0.7	0.8	3.8	0.4	-1.3	-0.4	-1.9	0.9	-0.1	0.2	-0.0	-1.3	-0.1	1.0
Fractured/broken bones in last 5 years	0.2	0.3	0.9	0.9	-0.5	0.3	-0.1	0.8	-0.8	-0.5	-0.0	-0.3	0.1	0.9
Age started oral contraceptive pill	0.4	0.5	3.1	-1.0	0.6	-0.5	-0.1	1.8	0.5	0.9	-0.2	0.1	-0.0	-0.1
Diastolic blood pressure, automated reading	0.4	1.2	4.5	-0.3	-0.5	-2.0	-1.5	2.1	-0.7	-0.3	0.7	-0.0	-0.1	-0.7
Ever depressed for a whole week	1.3	1.6	8.0	-0.2	1.0	2.8	1.0	-2.1	-0.1	-0.4	1.1	1.0	0.8	0.2
Unable to work because of sickness or disability	0.5	0.7	1.8	-0.3	-0.7	-0.4	0.7	0.6	-0.9	-0.7	-1.3	-1.0	-1.1	-0.7
Commuting to job workplace: Cycle	0.3	0.4	2.0	-0.5	0.1	-1.4	0.3	0.4	-0.0	-0.0	-0.6	0.1	-0.9	-0.7
Myopia	1.1	1.6	5.0	1.4	0.4	2.2	-0.3	-1.1	1.7	1.8	0.9	-0.5	1.2	1.2
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.5	-0.4	-0.2	-0.2	0.7	0.2	-0.2	-0.3	0.5	0.3	-0.6	-0.4
Cholesterol lowering medication	0.2	0.2	0.9	-0.0	0.6	-0.2	0.5	0.9	0.7	0.7	0.1	0.4	-0.2	-0.2
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	1.8	0.2	1.0	0.7	1.4	-1.1	-0.5	-0.8	0.8	1.2	1.1	0.7
Pain experienced in last month	1.1	1.8	4.4	-1.9	-2.0	0.3	-0.8	-1.2	-0.8	-1.2	-1.4	-0.4	-1.5	-2.1
Supplements: Calcium	0.2	0.2	0.6	-0.5	0.4	-0.5	0.1	0.7	0.4	0.7	-0.3	0.4	-0.2	-0.6
Basal cell carcinoma (self-reported)	1.1	1.3	5.8	-0.5	-1.3	-1.4	-1.6	2.4	-0.3	-0.1	-0.5	-1.1	-0.4	-0.5
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.4	0.3	0.7	-0.1	0.6	-0.2	0.5	0.5	-0.3	-0.2	-0.0	0.3
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	5.8	0.7	0.4	1.8	0.8	-0.6	0.5	0.4	1.3	0.7	2.4	1.3
Heart disease (siblings)	0.3	0.4	1.9	-0.5	0.3	-0.5	1.4	-0.5	-0.7	-0.9	-0.1	0.6	0.5	0.0
Alcohol drinker status: Previous	2.7	3.0	9.1	-2.6	-0.4	-1.4	0.2	-0.8	1.9	1.8	-1.4	-1.0	-2.2	-3.0
Pack years of smoking	0.9	1.4	5.7	-2.4	-0.5	0.4	1.0	-1.0	0.4	0.3	-1.4	-0.5	-1.0	-1.9
Impedance of whole body	0.3	1.5	3.2	1.0	-1.5	0.8	-1.2	1.3	-1.8	-1.5	0.1	-1.3	0.7	1.2
Leg fat mass (left)	0.3	1.1	3.2	-0.8	-1.8	0.7	-0.4	1.7	-0.4	0.0	-1.1	-1.5	-0.9	-0.2
Arm predicted mass (left)	0.3	1.6	5.2	1.7	0.2	2.3	-0.0	0.6	0.1	0.6	1.4	0.3	1.4	2.0