TWAS hub - PDS5A

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.054	0.023	0.0073	0.040	0.001	0.015	0.013	0.023	0.00001	0.22	0.00580	0.0083	0.00076
2	GTEx	Brain Cerebellar Hemisphere	0.261	0.090	0.0047	0.105	NA	0.122	NA	0.141	0.00120	NA	0.00051	NA	0.00018
3	GTEx	Testis	0.130	0.054	0.0078	0.001	NA	0.012	NA	-0.001	0.29000	NA	0.09200	NA	0.34000

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Rheumatoid Arthritis	6.9	9.5	13.5	2.9	3.7	2.6
Loneliness, isolation	5.1	7.0	10.2	-3.0	-3.2	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	4.8	6.4	11.1	-2.6	-3.3	-1.1
High blood pressure (mother)	4.8	6.7	9.9	-1.8	-2.6	-3.1
Myopia	4.2	6.0	9.3	-2.0	-3.0	-2.2
Noisy workplace	3.8	4.7	9.5	2.1	3.1	0.1
Supplements: Glucosamine	3.6	4.7	5.1	2.0	2.2	2.3
Guilty feelings	3.6	5.4	8.4	-2.8	-2.9	0.3
Neuroticism (2016)	3.4	4.9	7.7	-2.8	-2.6	-0.2
Depressed Affect (Nagel 2018)	3.2	6.7	9.8	-3.1	-3.1	-0.7
Comparative height size at age 10	3.2	17.4	28.9	-5.4	-4.6	-1.4
Handedness (chirality/laterality): Left-handed	3.2	3.9	5.6	-2.4	-2.3	-0.8
Angina	3.1	4.1	5.1	-1.7	-2.1	-2.2
Glaucoma (self-reported)	3.1	3.6	5.6	-2.3	-2.4	-0.4
Birth weight	3.0	6.6	8.0	-2.8	-2.8	-2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	3.0	3.9	6.2	-2.1	-2.5	-0.9
Medication: Levothyroxine sodium	2.9	5.0	7.7	2.3	2.8	1.3
Systolic blood pressure, automated reading	2.8	8.2	12.1	3.5	3.3	1.3
Wears glasses or contact lenses	2.8	3.3	7.6	1.1	1.0	2.8
Depression (Nagel 2018)	2.7	4.1	7.4	-1.9	-2.7	-1.1
Neuroticism (Nagel 2018)	2.6	6.2	10.2	-3.2	-2.9	-0.0
Neuroticism	2.6	6.3	9.7	-3.1	-3.0	0.3
Fed-up feelings	2.6	4.8	7.2	-2.7	-2.5	-1.0
Number of incorrect matches in round	2.6	4.3	9.6	-1.1	-1.5	-3.1
Angina (self-reported)	2.6	3.4	4.3	-1.5	-1.8	-2.1
Miserableness	2.6	4.5	6.8	-2.5	-2.6	-0.5
Neuroticism score	2.5	5.1	8.7	-2.9	-2.6	0.5
Eye problems/disorders: Cataract	2.5	2.8	4.7	2.2	1.9	-0.6
Tinnitus: Yes, now most or all of the time	2.5	2.9	3.8	-1.9	-1.9	-1.3
Lupus	2.4	3.7	6.2	2.5	1.8	1.2
Height	2.4	46.9	78.0	-8.8	-7.9	-0.5
Systolic Blood Pressure	2.4	12.1	20.7	4.5	3.7	1.5
Serious illness, injury or assault to yourself	2.4	3.0	5.3	2.3	1.9	0.1
Eye problems/disorders: Glaucoma	2.4	2.8	4.3	-2.1	-2.1	-0.2
Irritability	2.4	4.1	7.0	-2.6	-2.0	1.1
Standing height	2.2	22.2	37.7	-6.1	-5.3	-0.9
Exposure to tobacco smoke at home	2.2	2.4	4.0	-2.0	-1.4	-1.1
Alcohol intake frequency.	2.2	5.2	12.5	-1.1	-1.4	3.5
Age at First Birth	2.1	3.0	4.0	1.7	1.4	2.0
Vitamin and mineral supplements	2.1	2.9	3.9	-1.6	-1.5	-2.0
Nervous feelings	2.1	4.0	6.3	-2.5	-2.2	-0.9
Frequency of tenseness / restlessness in last 2 weeks	2.1	3.3	5.6	-1.4	-2.4	-1.6
Father’s age at death	2.1	2.9	5.4	-2.3	-1.4	1.1
Gout (self-reported)	2.1	2.8	6.9	-0.5	-1.2	-2.6
Number of full sisters	2.1	2.5	5.4	-2.3	-1.4	-0.5
Fractured/broken bones in last 5 years	2.1	2.7	3.4	-1.4	-1.8	-1.6
Deep venous thrombosis (DVT) (self-reported)	2.1	2.7	2.7	-1.7	-1.6	-1.7
Type 2 Diabetes (T2D) (2012)	2.0	2.4	3.8	-1.9	-1.7	-0.5
Sitting height	2.0	14.2	22.2	-4.7	-4.5	0.2
Blood clot in the leg (DVT)	2.0	2.6	3.1	-1.6	-1.5	-1.8
Forced vital capacity (FVC), Best measure	2.0	7.4	9.2	-3.0	-2.7	-2.5
Tinnitus: Yes, but not now, but have in the past	1.9	2.1	6.0	-0.1	-0.4	-2.5
Trunk fat-free mass	1.9	10.7	17.3	-4.2	-3.8	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	1.9	6.1	7.0	-2.6	-2.6	-2.1
Trunk predicted mass	1.9	11.0	17.8	-4.2	-3.9	0.5
Length of working week for main job	1.9	2.1	3.5	-1.9	-0.9	1.4
Reason for reducing amount of alcohol drunk: Health precaution	1.9	2.2	5.2	0.6	1.1	-2.3
Mood swings	1.9	3.4	6.1	-2.5	-2.0	0.4
Worry too long after embarrassment	1.8	3.0	4.4	-2.1	-2.1	0.7
Medication: Allopurinol	1.8	2.3	3.8	-1.3	-1.3	-1.9
Mineral and other dietary supplements	1.8	2.4	4.6	-1.6	-2.1	-0.2
Commuting to job workplace: Public transport	1.8	2.1	5.1	-2.3	-1.1	0.2
Diastolic blood pressure, automated reading	1.8	5.5	9.1	3.0	2.7	0.5
Hypothyroidism (self reported)	1.7	3.9	7.6	1.8	2.8	0.8
Medication for hormone replacement therapy	1.7	1.9	3.3	1.6	1.8	0.1
Qualifications: None of the above	1.7	3.7	6.0	-1.5	-1.7	-2.5
Hypothyroidism/myxoedema (self-reported)	1.7	3.2	6.3	1.6	2.5	0.9
Illnesses of siblings: Diabetes	1.7	2.1	4.3	-0.9	-1.1	-2.1
Ever taken oral contraceptive pill	1.7	1.9	3.8	-0.9	-1.0	-2.0
Arm fat-free mass (left)	1.7	8.7	14.5	-3.8	-3.4	0.4
Maternal smoking around birth	1.6	2.4	4.4	2.1	1.6	-0.4
Bilateral oophorectomy (both ovaries removed)	1.6	1.9	4.2	-1.0	-0.7	-2.1
Breastfed as a baby	1.6	2.0	3.0	1.7	1.7	0.4
Frequency of depressed mood in last 2 weeks	1.5	2.1	3.8	-1.5	-1.9	-0.4
Hair/balding pattern: Pattern 4	1.5	3.7	5.4	-1.9	-2.3	1.4
Arm predicted mass (right)	1.5	7.8	13.8	-3.7	-3.0	0.6
Whole body fat-free mass	1.5	8.6	14.1	-3.8	-3.4	0.7
Whole body water mass	1.5	8.4	13.6	-3.7	-3.3	0.7
Ever depressed for a whole week	1.5	1.8	2.7	-1.6	-0.7	-1.6
Pain experienced in last month	1.5	2.4	5.2	2.3	1.4	-0.1
Arm predicted mass (left)	1.5	7.6	12.5	-3.5	-3.2	0.5
Diverticular disease/diverticulitis (self-reported)	1.4	1.6	2.3	1.5	1.4	0.8
Frequency of tiredness / lethargy in last 2 weeks	1.4	2.3	3.7	-1.9	-1.6	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.2	3.7	-1.7	-1.9	-0.1
Arm fat-free mass (right)	1.4	7.1	12.4	-3.5	-2.9	0.7
Commuting to job workplace: Car/motor vehicle	1.4	1.6	4.3	2.1	0.7	0.3
Osteoarthritis (self-reported)	1.4	1.8	5.2	0.5	0.3	-2.3
Basal cell carcinoma (self-reported)	1.4	1.7	2.4	1.1	1.1	1.6
Fasting Glucose	1.3	1.5	2.9	-1.1	-0.7	-1.7
Average weekly fortified wine intake	1.3	1.5	3.2	-1.8	-1.1	0.3
Supplements: Fish oil (including cod liver oil)	1.3	1.7	3.8	0.5	1.1	-1.9
Average weekly beer plus cider intake	1.3	1.8	2.9	1.6	1.7	-0.4
Heart disease (siblings)	1.3	1.6	4.4	-0.4	0.4	-2.1
Intelligence (Savage-Jansen 2018)	1.2	3.8	11.2	0.1	0.6	3.3
Verbal and Numeric Reasoning (VNR)	1.2	3.0	6.7	1.1	1.0	2.6
Forced vital capacity (FVC)	1.2	4.6	5.2	-2.3	-1.9	-2.2
Alcohol intake versus 10 years previously	1.2	1.9	2.7	-1.1	-1.3	1.6
Shortness of breath walking on level ground	1.2	1.4	2.8	-0.9	-0.8	-1.7
Back pain experienced in last month	1.2	1.8	3.4	-1.8	-1.1	0.8
Basal metabolic rate	1.2	6.7	10.9	-3.3	-3.0	0.6
Average weekly spirits intake	1.1	1.3	2.1	0.8	1.1	1.5
Headache pain in last month	1.1	2.0	3.1	-1.8	-1.7	0.1
Medication for cholesterol, blood pressure or diabetes	1.1	1.9	3.6	-1.9	-1.4	-0.0
Medication: Ventolin 100micrograms inhaler	1.1	1.4	2.0	1.2	1.4	0.8
Chest pain or discomfort	1.1	1.6	4.6	-0.2	0.1	-2.1
Medication: Paracetamol	1.1	1.7	3.3	-1.3	-0.4	1.8
Major Depression (MDD)	1.0	1.2	2.1	-1.4	-1.2	-0.2
Waist Hip Ratio (WHR)	1.0	4.7	7.4	-1.1	-2.3	-2.7
Sensitivity / hurt feelings	1.0	1.7	2.5	-1.4	-0.8	1.6
Had other major operations	1.0	1.2	1.9	0.4	1.4	1.2
Prospective memory result	1.0	1.2	3.5	-0.1	-0.1	-1.9
Medication: Paracetamol	1.0	1.7	3.8	-2.0	-0.7	0.8
Medication: Amlodipine	1.0	1.5	3.6	-0.8	-0.5	1.9
Migraine (self-reported)	1.0	1.2	2.7	-1.6	-0.9	-0.0
Family relationship satisfaction	1.0	1.2	2.5	1.0	0.4	-1.6
Smoking status: Previous	1.0	1.6	2.6	1.2	1.6	-0.8
Smoking status: Current	1.0	1.6	2.0	-1.4	-1.4	-0.9
Pain type(s) experienced in last month: Hip pain	1.0	1.3	2.2	-1.0	-0.8	-1.5
Number of operations (self-reported)	1.0	1.5	2.6	0.5	1.6	1.2
Worry (Nagel 2018)	0.9	1.9	3.1	-1.7	-1.4	-0.7
Breast Cancer	0.9	2.2	3.2	1.6	0.9	-1.8
Heel T-Score	0.9	7.0	8.6	2.4	2.9	2.6
Hayfever, allergic rhinitis or eczema	0.9	1.9	3.3	-1.5	-1.8	-0.1
Past tobacco smoking	0.9	1.6	2.1	-1.0	-1.5	1.3
Diabetes (self-reported)	0.9	1.4	3.9	-0.5	-2.0	-0.5
Forced expiratory volume in 1-second (FEV1)	0.9	2.9	3.6	-1.9	-1.9	-1.3
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	2.5	0.6	1.1	1.6
Comparative body size at age 10	0.9	2.6	4.0	-1.3	-2.0	-1.4
Mean time to correctly identify matches	0.9	1.7	2.5	1.4	0.8	-1.6
Leg fat-free mass (right)	0.9	4.7	7.3	-2.7	-2.5	0.9
Qualifications: nursing, teaching	0.9	1.3	1.4	1.2	1.2	1.1
Leg predicted mass (right)	0.9	4.5	7.1	-2.7	-2.4	1.0
Financial situation satisfaction	0.9	1.1	3.1	0.4	0.1	-1.8
Medication: Atorvastatin	0.9	1.1	1.2	1.1	1.1	1.0
Ovarian Cancer	0.8	1.0	1.6	0.4	1.3	-1.1
Pack years adult smoking proportion	0.8	1.2	1.2	-1.1	-1.1	-1.0
Age when periods started (menarche)	0.8	2.0	5.7	0.1	-0.6	-2.4
Multivitamins +/- minerals	0.8	1.0	2.3	0.4	0.8	1.5
Fluid intelligence score	0.8	1.6	4.0	0.8	0.5	2.0
Hair/balding pattern: Pattern 3	0.8	1.3	1.8	1.4	1.3	0.4
Number of live births	0.8	1.2	2.0	0.7	1.0	1.4
Illnesses of mother	0.8	1.0	2.2	0.8	0.6	1.5
Age at first live birth	0.8	1.5	2.2	1.2	1.0	1.5
Neck or shoulder pain in last month	0.8	1.2	1.9	-0.9	-0.8	-1.4
Pulse rate, automated reading	0.8	2.6	3.4	1.4	1.8	1.6
Medication: Aspirin	0.8	1.0	2.6	-0.7	-1.6	0.0
Medication: Aspirin	0.8	1.1	2.6	-0.8	-1.6	0.1
Medication: Lisinopril	0.8	1.0	1.9	-1.4	-1.0	0.5
Schizophrenia vs Biploar Disorder	0.7	0.9	1.0	-0.9	-0.9	-1.0
Alzheimer’s Disease (including proxy)	0.7	1.1	2.7	1.6	0.7	-0.2
Reaction Time	0.7	1.3	3.2	0.8	0.1	-1.8
Triglycerides	0.7	1.1	1.8	-1.3	-1.1	-0.6
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.3	-1.1	-1.1	-0.4
Leg fat-free mass (left)	0.7	3.8	6.1	-2.5	-2.2	0.7
Townsend deprivation index at recruitment	0.7	1.0	1.8	-1.3	-0.7	-0.7
Leg predicted mass (left)	0.7	3.7	5.9	-2.4	-2.2	0.7
Lung cancer (father)	0.7	0.9	2.5	-0.2	-0.2	1.6
Ever highly irritable/argumentative for 2 days	0.7	0.8	2.4	0.0	-0.1	-1.5
Loud music exposure frequency	0.7	0.7	1.6	0.2	0.7	1.3
Pulse wave peak to peak time	0.7	0.8	1.5	-1.2	-0.8	0.4
Medication for pain relief, constipation, heartburn	0.7	1.1	2.3	1.5	1.0	0.1
Heart disease (mother)	0.7	0.9	1.6	-0.8	-0.6	-1.3
Suffer from ‘nerves’	0.7	1.0	1.8	-1.3	-1.1	0.4
Age at last live birth	0.7	1.0	2.8	0.0	-0.1	1.7
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	1.1	1.0	0.9	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	3.3	-1.8	-1.1	-0.1
Average weekly red wine intake	0.7	1.1	1.8	0.9	1.4	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	2.3	-0.6	-0.7	1.5
Average weekly champagne plus white wine intake	0.7	0.9	2.2	1.5	0.7	0.0
Crohns Disease (2017)	0.6	1.3	2.2	-0.4	-1.3	1.5
HbA1C	0.6	0.7	1.1	-0.9	0.4	1.1
Lung FVC	0.6	2.9	8.4	0.1	0.4	-2.9
Current tobacco smoking	0.6	0.9	1.2	-1.0	-1.1	-0.8
Heart attack	0.6	0.7	1.2	-0.4	-1.1	0.9
Pulse rate	0.6	1.1	1.9	1.4	1.0	0.5
Medication: Cholesterol lowering	0.6	1.0	1.8	1.4	1.0	0.2
Medication: Lansoprazole	0.6	0.7	1.0	-0.5	-1.0	-0.9
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.5	0.9	1.2	0.3
Exposure to tobacco smoke outside home	0.6	0.8	2.0	0.2	0.6	1.4
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.5	0.6	0.3	-1.2
Medication: Seretide 50 evohaler	0.6	0.6	1.2	-0.8	-1.1	-0.1
Leg pain on walking	0.6	0.8	1.5	-1.2	-0.8	0.4
Arm fat percentage (left)	0.6	2.3	3.6	1.9	1.8	0.1
Long-standing illness, disability or infirmity	0.6	0.8	1.0	0.8	1.0	0.9
Friendships satisfaction	0.6	0.7	1.1	1.0	-0.2	-1.1
Medication for cholesterol	0.6	0.9	2.0	-1.4	-0.8	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.3	-1.1	-0.8	-0.4
Ever smoked	0.6	1.1	1.6	0.6	1.1	-1.3
Alzheimer’s Disease (in mother)	0.5	0.6	1.7	0.2	-0.1	-1.3
Prostate Cancer	0.5	0.7	1.6	-0.6	0.1	1.3
LDL Cholesterol	0.5	0.7	1.5	0.8	0.2	-1.2
Primary Biliary Cirrhosis	0.5	0.8	1.6	0.6	0.5	1.3
Blood Red Count	0.5	4.5	8.5	-1.9	-2.9	-1.1
BMI	0.5	2.7	3.9	2.0	1.5	1.4
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.5	-0.1	-0.6	-1.2
Qualifications: CSEs or equivalent	0.5	0.7	1.5	-0.1	0.8	1.2
Had menopause	0.5	0.6	0.8	0.5	0.8	0.9
Medication: Ramipril	0.5	0.6	0.9	-0.4	-0.8	-1.0
Illnesses of siblings	0.5	0.7	1.9	0.3	-0.2	1.4
Arm fat percentage (right)	0.5	2.0	3.3	1.8	1.6	-0.0
Falls in the last year	0.5	0.6	1.8	0.1	-0.0	1.4
Birth weight of first child	0.5	0.9	1.7	-1.1	-1.3	-0.2
Leg fat percentage (right)	0.5	2.0	2.9	1.7	1.7	-0.3
Emphysema/chronic bronchitis	0.5	0.6	1.5	0.5	0.3	-1.2
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.8	-0.2	-0.2	1.3
Breast cancer (self-reported)	0.5	0.6	1.0	1.0	0.9	-0.1
Illnesses of father: High blood pressure	0.5	0.6	1.0	0.8	1.0	0.3
Unable to work because of sickness or disability	0.5	0.6	1.2	-1.1	-0.6	0.5
Bipolar Disorder (2018)	0.4	0.6	1.4	-0.4	0.4	1.2
Schizophrenia (2018)	0.4	0.8	1.4	-1.2	-1.0	-0.2
Hearing difficulty/problems: Yes	0.4	0.6	1.5	-0.3	0.4	1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	1.9	0.1	1.4	0.8
Mouth/teeth dental problems	0.4	0.7	1.0	-0.7	-1.0	-0.7
Pain all over the body in last month	0.4	0.5	0.8	-0.9	-0.7	-0.3
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	0.7	0.7	0.7	0.8
Time employed in main current job	0.4	0.5	0.8	-0.3	-0.8	0.9
Asthma	0.4	0.7	0.9	-0.9	-0.8	0.8
Tense / ‘highly strung’	0.4	0.6	1.0	-0.6	-1.0	-0.6
Body fat percentage	0.4	1.5	2.4	1.4	1.5	-0.4
Health satisfaction	0.4	0.6	1.6	0.3	-0.1	-1.2
Medication: Blood pressure	0.4	0.6	1.4	1.2	0.7	0.0
Knee pain experienced in last month	0.4	0.6	1.7	0.2	-0.2	-1.3
Asthma (self-reported)	0.4	0.7	0.9	-0.9	-0.8	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	1.6	-0.8	-0.6	-1.3
Hearing aid user	0.4	0.4	0.7	0.2	0.7	0.8
Mother’s age at death	0.4	0.6	0.9	-0.9	-0.8	-0.4
Alcohol drinker status: Never	0.4	0.5	1.0	-1.0	-0.5	0.3
Ever had prostate specific antigen (PSA) test	0.4	0.4	0.7	-0.8	-0.6	0.4
Age started oral contraceptive pill	0.4	0.5	0.9	-0.2	0.8	0.9
Heart attack/myocardial infarction (self-reported)	0.4	0.5	0.8	-0.2	-0.8	0.9
Pack years of smoking	0.4	0.7	1.1	-0.6	-0.7	-1.0
Bipolar Disorder or Schizophrenia	0.3	0.7	1.4	-1.2	-0.6	0.5
Alzheimer’s Disease (in father)	0.3	0.3	0.6	0.4	0.3	0.8
Ulcerative Colitis (UC)	0.3	0.5	0.8	0.9	0.4	0.7
Crohns Disease (2012)	0.3	0.5	1.3	0.4	-1.1	-0.0
Blood Platelet Count	0.3	3.0	7.8	-0.5	0.9	2.8
Blood White Count	0.3	2.0	3.3	-0.8	-1.4	-1.8
Lung FEV1/FVC ratio	0.3	1.4	3.3	1.0	0.1	1.8
Chronotype (morning person)	0.3	0.6	0.9	0.9	0.9	0.5
Ever had hysterectomy (womb removed)	0.3	0.4	0.6	0.8	0.5	-0.5
Diabetes (father)	0.3	0.4	0.6	0.1	-0.7	-0.8
Hand grip strength (right)	0.3	0.8	1.2	-1.0	-0.6	1.1
Hair/balding pattern: Pattern 2	0.3	0.4	1.1	0.2	0.0	-1.0
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.6	-0.6	0.0	-0.8
Weight	0.3	1.6	2.4	-1.6	-1.5	0.3
Pulse wave Arterial Stiffness index	0.3	0.3	0.7	0.8	0.4	-0.4
Impedance of arm (left)	0.3	1.5	1.7	1.2	1.3	-1.1
Wheeze or whistling in the chest in last year	0.3	0.6	1.4	0.4	0.5	-1.2
Qualifications: College or University degree	0.3	0.8	1.4	0.9	0.3	1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	0.7	0.8	-0.0	0.7
Had major operations	0.3	0.4	0.7	0.1	0.6	0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.6	-0.6	-0.2	-0.8
Diabetes diagnosed by doctor	0.3	0.5	1.4	0.2	-1.2	-0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.4	0.7	0.4	0.5	-0.8
Commuting to job workplace: Walk	0.3	0.3	0.5	-0.7	0.0	0.6
Leg fat percentage (left)	0.3	1.2	1.7	1.3	1.3	-0.3
Irritable Bowel Disease (IBD)	0.2	0.6	1.3	0.6	-0.4	1.1
Body Mass Index (BMI) (2010)	0.2	0.3	0.5	0.7	0.5	0.1
Coronary Artery Disease (CAD)	0.2	0.3	0.4	-0.6	-0.6	0.0
HDL Cholesterol	0.2	0.3	0.9	-0.2	-0.4	-0.9
Blood Eosinophil Count	0.2	1.5	2.8	1.7	1.3	0.4
Smoking Status	0.2	0.5	1.2	-0.6	-0.3	-1.1
Allergy or Eczema	0.2	0.6	0.9	-0.9	-0.9	0.3
Type 2 Diabetes (T2D) (2018)	0.2	0.3	0.9	1.0	-0.2	-0.3
Number of treatments/medications taken	0.2	0.3	0.7	0.3	0.3	0.9
Relative age of first facial hair	0.2	0.4	0.9	0.5	0.9	0.0
Supplements: Zinc	0.2	0.2	0.6	0.8	0.2	0.1
Diabetes (mother)	0.2	0.3	0.7	-0.4	0.3	0.8
Trunk fat percentage	0.2	0.9	1.4	1.0	1.2	-0.4
Relative age voice broke	0.2	0.2	0.5	0.2	0.4	0.7
Stomach or abdominal pain in last month	0.2	0.2	0.5	-0.7	-0.3	0.2
Medication: Atenolol	0.2	0.2	0.4	0.6	0.5	0.3
Body mass index (BMI)	0.2	1.1	1.6	1.3	1.0	0.8
Alcohol usually taken with meals	0.2	0.3	0.5	0.7	0.5	-0.4
Financial difficulties in last 2 years	0.2	0.3	0.5	0.5	0.4	-0.7
Medication: Simvastatin	0.2	0.3	0.7	0.8	0.5	-0.3
Impedance of arm (right)	0.2	0.9	1.7	0.7	0.7	-1.3
Worrier / anxious feelings	0.2	0.4	0.7	-0.8	-0.2	0.8
Happiness	0.2	0.3	0.5	0.3	-0.5	-0.7
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.4	0.1	-0.1	1.2
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.5	0.1	0.7	0.3
Depression (self-reported)	0.2	0.2	0.3	-0.5	-0.5	-0.3
Number of children fathered	0.2	0.2	0.4	0.6	0.6	-0.1
Medication: Ibuprofen	0.2	0.3	0.7	0.4	0.8	0.2
Medication: Omeprazole	0.2	0.2	0.5	-0.7	-0.1	-0.3
Overall health rating	0.2	0.5	0.9	0.6	0.4	-1.0
Supplements: Vitamin C	0.2	0.2	0.6	0.8	-0.2	-0.0
Medication: Gliclazide	0.2	0.2	0.3	0.3	-0.6	-0.5
Illnesses of father: None of the above (group 1)	0.2	0.3	0.6	-0.0	0.7	0.5
High cholesterol (Self-reported)	0.2	0.4	0.9	0.2	0.6	1.0
Medication: Bendroflumethiazide	0.2	0.3	0.6	0.8	0.5	-0.4
Commuting to job workplace: Cycle	0.2	0.3	0.7	0.8	0.4	0.3
Impedance of whole body	0.2	0.9	2.3	0.3	0.6	-1.5
Mean Putamen Volume	0.1	0.1	0.1	0.3	-0.3	0.1
Schizophrenia (2014)	0.1	0.2	0.4	-0.5	-0.2	-0.6
Ulcerative Colitis	0.1	0.2	0.4	0.4	-0.3	-0.6
Cardiovascular Disease	0.1	0.3	0.7	0.9	0.3	0.1
Respiratory disease	0.1	0.2	0.3	-0.2	-0.5	0.5
Hair Pigment	0.1	1.9	3.4	1.8	1.5	-0.2
Tanning	0.1	0.8	1.9	-0.0	0.7	1.4
Hand grip strength (left)	0.1	0.4	0.5	-0.7	-0.6	0.6
Medication: Co-codamol	0.1	0.2	0.3	-0.4	0.5	-0.1
Medication: Metformin	0.1	0.1	0.4	0.2	-0.6	-0.1
Impedance of leg (right)	0.1	0.6	1.5	-0.2	0.4	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.9	-0.9	0.1	-0.4
Chronic bronchitis/emphysema (father)	0.1	0.1	0.3	0.1	0.2	0.5
Impedance of leg (left)	0.1	0.6	1.6	-0.5	0.1	-1.3
Waist circumference	0.1	0.3	0.5	-0.3	-0.7	-0.5
Hearing difficulty/problems with background noise	0.1	0.1	0.2	0.0	0.2	0.5
Allergy	0.1	0.3	0.5	0.7	0.7	0.2
Hip circumference	0.1	0.4	0.6	-0.8	-0.4	0.6
Mouth/teeth dental problems: Dentures	0.1	0.2	0.5	0.3	0.3	0.7
Pulse wave reflection index	0.1	0.1	0.2	0.1	-0.3	0.4
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.3	-0.2	0.6	-0.3
High blood pressure (siblings)	0.1	0.1	0.3	-0.1	0.5	-0.3
Number of full brothers	0.1	0.1	0.4	0.6	0.2	-0.0
Eye problems/disorders: None of the above	0.1	0.2	0.3	-0.5	-0.5	0.0
Leg fat mass (right)	0.1	0.3	0.5	0.6	0.7	-0.2
Illnesses of father: Heart disease	0.1	0.2	0.5	0.7	-0.1	-0.2
Ever had bowel cancer screening	0.1	0.1	0.3	0.6	0.1	0.0
Medication: Blood pressure	0.1	0.1	0.2	0.3	0.0	-0.4
Risk taking	0.1	0.2	0.5	-0.1	-0.1	-0.7
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.4	-0.2	0.6	0.3
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.2	-0.3	0.4	0.2
Supplements: Calcium	0.1	0.1	0.2	-0.2	-0.3	0.5
Alcohol drinker status: Previous	0.1	0.1	0.3	0.6	-0.2	-0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Eye problems/disorders: Diabetes related eye disease	0.0	0.0	0.0	-0.2	0.1	0.1
Severe depression (siblings)	0.0	0.0	0.0	0.1	-0.1	-0.0
Taking other prescription medications	0.0	0.1	0.1	-0.2	0.0	-0.3
High blood pressure	0.0	0.1	0.2	0.5	-0.0	-0.0
Trunk fat mass	0.0	0.0	0.1	0.1	0.2	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.1	0.1	-0.1	-0.3	0.2
Arm fat mass (right)	0.0	0.1	0.1	0.3	0.3	0.2
Peak expiratory flow (PEF)	0.0	0.1	0.1	0.0	-0.2	0.4
Whole body fat mass	0.0	0.1	0.3	0.3	0.5	0.0
Hypertension (Self-reported)	0.0	0.1	0.1	0.3	-0.3	-0.3
Osteoporosis (self-reported)	0.0	0.0	0.0	0.0	-0.2	-0.2
Arm fat mass (left)	0.0	0.1	0.2	0.4	0.3	0.2
Number of self-reported non-cancer illnesses	0.0	0.0	0.1	0.2	0.0	0.3
Cholesterol lowering medication	0.0	0.1	0.1	0.2	-0.2	-0.3
Leg fat mass (left)	0.0	0.2	0.3	0.5	0.6	-0.0

Hub : Genes

PDS5A

Models

Trait associations