Hub : Genes

PCDHGB7

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0510 0.0240 0.0150 0.025 -0.002 0.016 0.003 0.019 0.00040 0.6100 0.0038 0.12 0.0019
2 GTEx Artery Aorta 0.1250 0.0530 0.0040 0.010 NA 0.025 NA 0.017 0.08800 NA 0.0140 NA 0.0360
3 GTEx Brain Cortex 0.2530 0.1030 0.0092 0.052 NA -0.009 NA 0.008 0.01500 NA 0.7000 NA 0.1900
4 TCGA Lung Adenocarcinoma 0.0356 0.0199 0.0024 0.023 0.025 0.011 NA 0.019 0.00097 0.0005 0.0160 NA 0.0023

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.3 0.5 0.6 -0.5 -0.7 -0.8 0.7
Bipolar Disorder or Schizophrenia 0.3 0.7 1.3 -0.9 1.2 -0.1 -0.7
Depressed Affect (Nagel 2018) 0.7 1.4 4.9 0.0 -0.0 -2.2 0.9
Depression (Nagel 2018) 0.3 0.5 0.6 -0.5 -0.8 -0.7 0.7
Intelligence (Savage-Jansen 2018) 1.4 4.2 6.7 2.6 -2.0 -0.4 2.5
Neuroticism (Nagel 2018) 0.6 1.4 3.1 -1.8 0.5 -1.5 -0.1
Schizophrenia (2018) 0.9 1.9 4.5 -0.8 2.1 0.5 -1.5
Schizophrenia vs Biploar Disorder 1.7 2.3 6.0 -1.2 1.1 0.7 -2.4
Worry (Nagel 2018) 2.0 4.2 10.8 -3.3 1.4 -0.8 -1.8
Alzheimer’s Disease (in mother) 0.5 0.6 1.0 1.0 0.2 -0.8 0.9
Alzheimer’s Disease (in father) 0.7 0.8 1.2 -0.7 -0.8 -0.9 -1.1
Alzheimer’s Disease (including proxy) 0.3 0.4 0.6 0.2 0.7 -0.7 -0.7
Crohns Disease (2017) 0.5 1.2 3.2 1.8 1.1 0.1 -0.5
Irritable Bowel Disease (IBD) 1.2 2.9 3.4 1.4 1.9 1.6 -1.8
Ulcerative Colitis (UC) 1.4 2.5 3.9 1.1 1.2 2.0 -1.9
Major Depression (MDD) 1.0 1.2 3.7 -1.0 -0.1 -1.9 0.3
Reaction Time 0.4 0.9 1.7 -0.5 0.3 1.2 -1.3
Verbal and Numeric Reasoning (VNR) 1.1 2.5 8.4 2.9 -0.6 -0.6 1.0
Breast Cancer 1.2 3.0 5.6 2.0 -1.0 -1.2 2.4
Ovarian Cancer 0.2 0.3 0.4 0.5 0.3 0.7 -0.5
Prostate Cancer 0.1 0.2 0.6 0.8 -0.1 0.2 0.0
Age at First Birth 0.6 0.8 2.0 -1.1 -0.2 -1.4 -0.3
Bipolar Disorder (2011) 0.5 0.4 1.4 0.2 -0.0 -0.6 1.2
Body Mass Index (BMI) (2010) 0.4 0.5 1.4 1.2 0.5 0.0 0.6
Coronary Artery Disease (CAD) 0.7 0.9 1.1 1.0 0.8 -0.9 -1.1
Crohns Disease (2012) 1.0 1.6 2.8 1.7 1.4 0.9 -0.9
Mean Putamen Volume 0.8 0.9 1.3 0.9 -0.7 -1.0 1.2
Fasting Glucose 0.5 0.6 0.9 -1.0 0.8 0.3 -0.8
HbA1C 0.6 0.7 1.6 0.5 -1.3 0.9 0.4
HDL Cholesterol 0.4 0.7 1.5 0.3 1.0 1.2 -0.4
LDL Cholesterol 0.3 0.4 0.9 0.5 -0.4 0.9 -0.6
Lupus 0.4 0.7 1.7 -0.1 -0.3 -0.9 1.3
Neuroticism (2016) 0.2 0.3 0.7 0.4 0.6 0.2 0.9
Primary Biliary Cirrhosis 0.8 1.1 2.3 -0.6 1.1 -0.7 -1.5
Rheumatoid Arthritis 3.5 4.8 8.7 2.0 -2.5 -0.5 2.9
Schizophrenia (2014) 0.5 1.0 1.7 -1.3 0.5 0.8 -1.3
Triglycerides 0.2 0.3 0.8 0.9 -0.5 0.3 0.3
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.4 -0.2 -0.2 -0.7 0.0
Ulcerative Colitis 1.1 1.5 2.0 0.9 1.4 1.2 -1.3
Blood Eosinophil Count 0.4 2.7 5.6 1.6 -0.1 1.7 2.4
Blood Platelet Count 0.8 9.8 23.7 4.9 1.4 -2.1 3.0
Blood Red Count 0.1 0.9 1.6 0.6 1.3 1.1 0.8
Blood White Count 1.1 7.8 22.7 0.9 4.8 2.8 -0.0
Heel T-Score 0.4 3.2 9.2 -3.0 -0.4 -0.5 -1.7
BMI 0.5 2.8 6.4 2.5 1.6 0.8 1.4
Height 0.7 12.9 40.6 -2.2 -6.4 -2.1 1.2
Waist Hip Ratio (WHR) 0.0 0.1 0.5 -0.0 0.1 0.7 -0.3
Systolic Blood Pressure 0.7 3.4 9.4 -0.5 3.1 1.3 -1.5
Smoking Status 0.2 0.4 0.8 0.6 0.9 -0.1 0.6
Allergy or Eczema 3.2 8.5 14.4 -1.9 -3.8 -3.2 2.4
Cardiovascular Disease 0.3 1.1 2.2 1.5 1.2 0.1 1.0
Hypothyroidism (self reported) 0.1 0.2 0.4 -0.5 -0.0 0.6 0.2
Respiratory disease 0.2 0.4 1.1 -0.3 -1.0 -0.7 0.3
Type 2 Diabetes (T2D) (2018) 1.1 2.1 5.4 1.1 -1.3 -0.5 2.3
Lung FEV1/FVC ratio 0.0 0.2 0.5 -0.7 0.6 0.1 -0.3
Lung FVC 0.2 0.9 2.5 0.5 0.9 -0.2 -1.6
Neuroticism 1.1 2.7 9.3 -3.0 -0.1 -1.0 -0.8
Chronotype (morning person) 1.1 2.4 7.2 -0.4 1.5 0.3 -2.7
Hair Pigment 0.0 0.8 2.9 0.0 0.3 0.5 1.7
Tanning 0.1 1.5 3.1 1.8 1.5 -0.7 -0.0
Hand grip strength (left) 1.6 4.1 8.6 2.6 -0.4 -0.8 2.9
Number of treatments/medications taken 1.9 3.4 7.9 1.7 -1.6 -0.1 2.8
Average weekly spirits intake 2.4 3.0 6.7 -1.7 -2.6 0.1 1.4
Sensitivity / hurt feelings 0.3 0.5 1.3 -0.7 0.5 -1.1 0.2
Frequency of depressed mood in last 2 weeks 0.3 0.5 1.0 -1.0 -0.5 -0.7 -0.3
Hearing difficulty/problems: Yes 0.6 1.0 2.9 -0.8 -0.5 -1.7 0.4
Relative age of first facial hair 0.3 0.6 1.3 -1.1 -0.8 -0.4 -0.4
Other serious medical condition/disability diagnosed by doctor 1.9 2.4 5.3 1.3 -2.3 -1.0 1.3
Ever used hormone-replacement therapy (HRT) 1.9 2.5 5.7 1.2 -1.3 1.0 2.4
Ever had hysterectomy (womb removed) 0.6 0.7 2.1 0.3 -0.8 -0.3 1.4
Systolic blood pressure, automated reading 1.0 2.9 5.8 -0.2 2.3 2.4 -0.7
Eye problems/disorders: Diabetes related eye disease 0.7 0.8 2.7 0.2 0.1 -0.5 1.6
Angina 3.4 4.4 8.5 2.8 1.1 -0.1 2.9
Medication for hormone replacement therapy 1.7 1.9 3.7 1.2 -1.9 -0.4 1.5
Vitamin and mineral supplements 1.1 1.5 3.1 0.6 -1.1 -1.3 1.8
Supplements: Zinc 1.1 1.2 3.0 -0.5 0.7 -1.0 -1.7
Medication: Co-codamol 0.6 0.7 1.5 -0.8 1.2 -0.3 -0.6
Medication: Metformin 0.7 1.0 3.3 0.8 0.1 0.1 1.8
Diabetes (father) 0.1 0.1 0.3 -0.1 0.0 -0.6 0.3
Diabetes (mother) 0.8 1.0 1.6 -1.3 -1.0 -1.1 0.3
Severe depression (siblings) 0.8 0.9 2.5 -0.8 -0.6 -1.6 0.5
Pack years adult smoking proportion 1.1 1.7 6.6 -0.2 0.1 2.6 0.0
Impedance of leg (right) 1.1 5.4 15.8 -1.6 -4.0 -0.2 1.9
Leg fat-free mass (left) 0.0 0.1 0.3 0.2 -0.2 0.3 -0.5
Trunk fat percentage 1.2 4.9 10.6 0.6 -2.9 -0.3 3.3
Hand grip strength (right) 1.2 3.3 6.7 2.6 0.6 -1.2 2.2
Townsend deprivation index at recruitment 2.2 3.0 5.1 2.0 1.7 0.1 2.3
Current tobacco smoking 0.4 0.6 1.3 0.1 1.1 1.0 -0.4
Average weekly fortified wine intake 0.6 0.7 2.3 -0.7 0.3 0.3 -1.5
Maternal smoking around birth 0.4 0.6 1.5 -0.3 -0.5 1.2 0.8
Fed-up feelings 0.6 1.0 3.5 0.3 0.5 -1.9 0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.0 0.0 0.2 -0.1 -0.1 0.0 0.4
Relative age voice broke 0.1 0.1 0.2 -0.0 0.4 0.3 0.2
Taking other prescription medications 1.5 2.3 5.6 -0.1 -2.4 -0.4 1.8
Age when periods started (menarche) 0.7 1.8 4.5 0.9 -1.1 0.8 2.1
Bilateral oophorectomy (both ovaries removed) 1.6 1.8 5.9 0.1 -2.4 0.4 1.1
Heel bone mineral density (BMD) T-score, automated (left) 0.8 1.7 2.5 -1.5 1.3 0.7 -1.6
Tinnitus: Yes, but not now, but have in the past 1.4 1.5 4.1 0.8 -1.0 -0.1 2.0
Qualifications: CSEs or equivalent 0.3 0.4 0.9 0.8 -0.1 -0.4 0.9
Serious illness, injury or assault to yourself 0.7 0.9 3.0 0.5 -0.5 0.1 1.7
High blood pressure 0.1 0.4 0.6 0.8 0.6 0.6 0.5
Hayfever, allergic rhinitis or eczema 2.2 4.7 7.7 -1.9 -2.7 -2.8 0.5
Multivitamins +/- minerals 0.4 0.6 1.4 -0.8 0.1 0.5 -1.2
Stomach or abdominal pain in last month 0.2 0.2 0.7 -0.3 -0.4 0.2 0.8
Supplements: Glucosamine 0.5 0.6 1.6 0.6 0.5 0.4 -1.3
Diverticular disease/diverticulitis (self-reported) 1.9 2.2 4.3 -2.1 -1.6 0.2 -1.4
Medication: Atenolol 0.8 1.0 2.2 1.0 1.5 0.7 0.5
Medication: Levothyroxine sodium 0.1 0.3 0.4 0.6 -0.6 0.2 0.5
Sitting height 0.7 5.1 14.7 -1.3 -3.8 -2.0 0.2
Chronic bronchitis/emphysema (father) 1.4 1.6 3.9 0.7 -2.0 0.4 1.4
High blood pressure (mother) 0.8 1.1 4.5 -0.3 -0.2 -0.2 2.1
Body mass index (BMI) 0.4 1.5 3.2 1.8 0.7 0.4 1.5
Impedance of leg (left) 1.2 5.8 15.8 -1.5 -4.0 -0.5 2.2
Leg predicted mass (left) 0.0 0.1 0.3 0.3 -0.2 0.2 -0.5
Trunk fat mass 1.0 4.1 8.0 0.7 -2.8 -0.4 2.8
Waist circumference 0.2 0.7 1.2 0.4 -0.9 0.6 1.1
Number of incorrect matches in round 0.1 0.2 0.8 0.2 0.9 0.1 0.1
Past tobacco smoking 0.2 0.3 0.8 -0.0 -0.5 0.9 -0.5
Alcohol usually taken with meals 0.3 0.4 1.0 -0.1 0.5 1.0 -0.7
Nervous feelings 1.0 1.9 7.0 -2.6 -0.2 -0.3 -0.7
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 1.1 -0.5 1.0 0.7 -0.7
Hearing difficulty/problems with background noise 1.0 1.6 2.8 -1.7 -0.9 -1.4 1.0
Hair/balding pattern: Pattern 2 0.5 0.6 1.3 1.1 0.5 0.0 0.9
Had menopause 0.4 0.6 2.0 1.4 0.2 0.4 0.3
Had other major operations 2.4 2.9 7.5 0.3 -2.7 -1.5 1.3
Forced vital capacity (FVC) 0.8 3.0 5.2 -1.7 -1.0 -1.6 -2.3
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.1 2.6 -1.6 1.2 0.0 -0.6
Ever unenthusiastic/disinterested for a whole week 2.7 3.2 8.9 -0.6 -3.0 -1.1 1.6
Qualifications: None of the above 0.2 0.4 0.7 0.8 -0.0 -0.3 0.8
Financial difficulties in last 2 years 0.6 0.8 1.8 1.3 -0.5 0.6 0.8
Mouth/teeth dental problems 1.5 2.4 6.3 -2.5 -1.6 0.7 -0.4
Heart attack 2.4 3.0 3.5 1.4 1.8 1.8 1.9
Allergy 1.6 3.7 9.3 1.5 3.0 1.8 -0.3
Pain all over the body in last month 0.5 0.5 1.5 -0.6 -0.0 -0.4 -1.2
Diabetes (self-reported) 2.2 3.3 8.4 1.5 -1.0 -1.3 2.9
Hayfever/allergic rhinitis (self-reported) 0.9 1.2 3.1 -1.8 -1.1 -0.6 -0.2
Medication: Ramipril 0.4 0.6 1.2 -0.2 1.1 -0.6 -0.8
Medication: Simvastatin 2.1 3.1 6.7 2.6 0.5 0.2 2.3
Fluid intelligence score 1.4 2.8 8.0 2.8 1.8 0.2 -0.4
Illnesses of siblings 1.5 2.1 4.7 -1.2 1.6 -0.3 -2.2
Neuroticism score 0.9 1.8 6.1 -2.5 0.2 -0.9 -0.5
Weight 0.3 1.5 3.1 0.5 -1.8 -0.1 1.6
Impedance of arm (right) 1.2 5.6 15.5 -1.4 -3.9 -0.7 2.1
Arm fat percentage (right) 0.5 2.2 5.5 1.2 -1.3 -0.1 2.3
Trunk fat-free mass 0.1 0.4 1.4 -0.1 -1.2 -0.3 -0.4
Hip circumference 0.1 0.6 1.5 0.2 -1.2 -0.1 1.0
Time employed in main current job 2.0 2.3 5.8 -0.0 -1.8 -2.4 0.6
Alcohol intake versus 10 years previously 0.5 0.7 2.6 0.1 1.6 -0.1 0.5
Father’s age at death 1.9 2.6 7.7 -0.7 -2.8 1.1 -0.9
Worrier / anxious feelings 0.8 1.6 3.5 -1.9 0.9 -0.7 -1.3
Frequency of tiredness / lethargy in last 2 weeks 2.3 3.7 6.5 0.8 -2.5 -2.5 1.3
Falls in the last year 0.7 1.0 1.5 1.2 1.0 -0.2 1.2
Hair/balding pattern: Pattern 3 0.8 1.1 2.9 -0.6 0.5 1.7 -1.0
Number of live births 0.6 0.9 1.6 0.8 1.3 1.1 -0.1
Forced expiratory volume in 1-second (FEV1) 0.6 2.1 4.6 -1.5 -0.2 -1.1 -2.2
Pulse rate 0.2 0.4 1.0 -0.2 0.6 -1.0 -0.5
Happiness 0.8 1.0 1.9 0.4 -1.3 -1.4 0.4
Noisy workplace 0.2 0.2 0.6 0.3 -0.4 -0.2 0.8
Qualifications: A levels/AS levels or equivalent 0.8 1.9 4.6 -1.5 0.8 -0.3 -2.1
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.4 1.0 1.0 -0.6 -0.5 -0.0
Mouth/teeth dental problems: Dentures 1.0 1.7 6.5 2.5 0.6 0.4 0.2
Asthma 0.4 0.7 1.3 -0.7 -0.9 0.5 -1.1
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.0 2.4 -0.2 -1.6 -1.2 0.5
Medication: Cholesterol lowering 3.2 4.9 9.9 3.1 -0.0 -0.6 3.1
Depression (self-reported) 0.7 0.9 2.7 -0.3 -0.9 0.1 1.6
Medication: Lansoprazole 0.8 0.9 2.9 0.0 -1.7 -0.0 0.9
Prospective memory result 0.9 1.1 2.3 0.6 -1.5 0.8 1.1
Lung cancer (father) 0.2 0.3 0.6 0.8 0.3 -0.7 -0.2
Illnesses of mother 1.2 1.5 5.4 -0.5 0.0 0.5 -2.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.3 3.6 -1.2 -0.1 -0.5 -1.9
Pulse wave Arterial Stiffness index 0.3 0.3 0.4 0.6 0.2 0.7 0.6
Impedance of arm (left) 1.1 5.3 15.0 -2.0 -3.9 -0.5 1.4
Arm fat mass (right) 0.3 1.3 2.9 0.9 -1.1 0.2 1.7
Trunk predicted mass 0.1 0.5 1.7 -0.1 -1.3 -0.2 -0.4
Standing height 1.0 9.6 29.5 -2.8 -5.4 -1.0 0.4
Length of working week for main job 1.4 1.5 3.2 -0.6 -1.1 1.8 -1.1
Exposure to tobacco smoke at home 0.6 0.6 1.8 0.7 1.3 0.5 -0.3
Breastfed as a baby 1.2 1.5 3.1 -1.6 0.3 0.6 -1.8
Tense / ‘highly strung’ 1.5 2.4 3.4 -1.6 1.6 -1.8 -1.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 0.9 1.4 -0.8 -0.6 -1.2 1.0
Hair/balding pattern: Pattern 4 0.6 1.6 3.8 0.2 1.3 -1.9 -0.9
Birth weight of first child 2.8 5.0 16.0 0.2 -4.0 -1.3 1.5
Peak expiratory flow (PEF) 0.4 0.9 1.5 0.4 1.2 0.6 -1.2
Pulse wave reflection index 0.3 0.3 0.6 0.4 -0.7 0.8 0.4
Ever highly irritable/argumentative for 2 days 1.7 2.0 3.8 -1.5 -1.4 -1.9 0.3
Loud music exposure frequency 2.2 2.4 6.7 -1.0 -2.6 0.0 1.4
Qualifications: O levels/GCSEs or equivalent 0.5 0.7 1.6 -0.1 -1.0 -0.7 -1.3
Mouth/teeth dental problems: Bleeding gums 2.6 3.3 9.6 1.6 3.1 -0.1 -1.1
Blood clot in the leg (DVT) 1.9 2.4 7.5 0.8 -2.7 0.4 1.2
Medication: Paracetamol 0.4 0.6 1.3 -0.7 -0.2 -0.7 1.2
Headache pain in last month 1.5 2.5 8.0 -2.8 -0.9 -0.9 -0.6
Medication for cholesterol, blood pressure or diabetes 1.9 3.2 7.3 -2.2 0.5 0.4 -2.7
Glaucoma (self-reported) 1.0 1.1 2.3 -1.4 -1.5 -0.2 0.3
Gout (self-reported) 1.5 2.0 5.9 1.4 0.2 -2.4 0.5
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 1.4 -0.3 -1.2 -0.2 0.3
Medication: Amlodipine 0.8 1.2 3.3 -0.7 1.8 0.8 -0.5
Medication: Ventolin 100micrograms inhaler 0.8 1.0 2.2 -0.7 0.4 1.5 -1.0
Birth weight 1.2 2.7 7.2 -0.0 -2.7 0.1 1.9
Chronic bronchitis/emphysema (mother) 1.3 1.5 2.9 0.8 -1.7 0.9 1.3
High blood pressure (siblings) 0.9 1.3 3.8 0.9 -0.7 0.6 1.9
Forced vital capacity (FVC), Best measure 0.4 1.5 3.1 -1.1 -0.7 -1.2 -1.7
Body fat percentage 1.1 4.3 9.7 0.8 -2.6 -0.2 3.1
Leg fat percentage (right) 0.9 3.4 8.1 0.8 -2.2 -0.1 2.8
Arm fat-free mass (right) 0.0 0.1 0.3 0.2 -0.2 0.5 -0.5
Exposure to tobacco smoke outside home 0.3 0.4 0.8 0.0 0.8 0.9 0.4
Comparative body size at age 10 0.1 0.3 0.6 -0.0 0.5 0.3 -0.8
Number of full brothers 0.4 0.5 1.2 1.1 -0.3 0.2 0.7
Worry too long after embarrassment 1.4 2.3 4.7 -2.2 1.0 1.5 -1.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.6 1.5 0.4 0.4 0.7 1.2
Wheeze or whistling in the chest in last year 1.1 1.9 5.6 -0.3 -1.1 2.4 0.9
Number of children fathered 0.0 0.0 0.0 -0.1 0.0 0.1 -0.1
Reason for reducing amount of alcohol drunk: Health precaution 1.6 1.8 4.8 0.1 -0.8 -2.2 1.4
Age at first live birth 0.7 1.2 1.5 -1.2 -0.6 -1.2 -1.1
Pulse wave peak to peak time 0.4 0.5 0.8 -0.8 -0.5 -0.9 -0.6
Health satisfaction 2.0 2.6 5.3 2.3 -1.2 -1.1 1.5
Shortness of breath walking on level ground 2.1 2.5 3.5 1.6 -1.9 -0.7 1.9
Qualifications: College or University degree 0.9 2.8 5.3 -2.3 -1.8 -0.4 -1.6
Eye problems/disorders: None of the above 1.0 1.1 2.2 -0.5 1.5 -1.1 -0.8
Mouth/teeth dental problems: Loose teeth 1.7 2.0 3.8 0.7 1.9 1.9 -0.6
Emphysema/chronic bronchitis 0.8 0.9 1.8 -0.0 -0.3 -1.3 1.3
Medication for pain relief, constipation, heartburn 0.5 0.9 3.0 -0.6 -0.1 0.3 -1.7
Neck or shoulder pain in last month 0.3 0.4 0.7 -0.6 -0.4 -0.6 -0.8
Medication: Blood pressure 1.2 2.1 4.3 1.5 -0.9 -1.2 2.1
Angina (self-reported) 3.5 4.6 9.2 3.0 1.7 0.2 2.5
Migraine (self-reported) 1.3 1.7 5.3 -1.0 0.0 2.3 -0.7
Medication: Ibuprofen 0.7 0.9 1.7 -0.7 -1.3 -1.1 0.4
Medication: Allopurinol 1.0 1.3 2.5 0.9 0.7 -1.6 1.2
Medication: Omeprazole 0.8 0.9 1.8 0.2 0.3 1.4 1.3
Medication: Seretide 50 evohaler 1.5 1.7 2.7 0.5 -1.4 -1.6 1.5
Mean time to correctly identify matches 0.1 0.1 0.4 0.1 -0.6 0.2 0.3
Heart disease (mother) 1.0 1.2 3.0 -0.6 -1.1 0.3 1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.4 1.6 3.0 -1.7 1.3 -0.5 -1.2
Whole body fat mass 0.6 2.5 5.2 0.6 -2.1 0.1 2.3
Leg fat mass (right) 0.4 1.6 3.3 0.6 -1.6 0.1 1.8
Arm predicted mass (right) 0.0 0.2 0.6 -0.0 -0.1 0.3 -0.8
Pulse rate, automated reading 0.1 0.3 0.5 -0.5 -0.7 -0.3 -0.5
Alcohol intake frequency. 0.2 0.4 1.4 0.4 -0.0 0.2 1.2
Comparative height size at age 10 0.5 2.7 8.9 -1.3 -3.0 -0.4 0.5
Number of full sisters 0.6 0.7 1.4 1.2 1.1 0.0 0.5
Suffer from ‘nerves’ 0.1 0.1 0.3 -0.1 0.2 -0.2 0.6
Overall health rating 0.9 1.9 4.4 1.5 -0.7 0.7 2.1
Chest pain or discomfort 1.1 1.6 2.5 0.6 -1.5 -1.1 1.6
Had major operations 1.3 1.6 4.7 -0.3 -2.2 -1.1 0.6
Age at last live birth 0.7 1.1 2.5 -0.2 -1.6 -1.1 0.7
Family relationship satisfaction 0.4 0.5 1.0 1.0 0.3 -1.0 0.0
Leg pain on walking 1.9 2.4 3.6 1.6 -1.7 -0.7 1.9
Qualifications: NVQ or HND or HNC or equivalent 1.7 2.1 4.3 2.1 0.3 1.2 1.6
Commuting to job workplace: Car/motor vehicle 1.0 1.2 3.4 -1.8 -0.8 0.2 -0.8
Illness, injury, bereavement, stress in last 2 years 1.0 1.3 2.9 -1.7 0.4 -0.1 -1.4
Medication: Aspirin 2.5 3.3 6.1 2.3 -0.3 -1.3 2.5
Supplements: Vitamin C 0.0 0.0 0.1 -0.0 -0.1 -0.3 0.1
Knee pain experienced in last month 0.7 1.0 3.1 0.0 -0.4 0.9 1.8
Hypertension (Self-reported) 0.2 0.5 1.0 1.0 0.2 0.5 0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.8 1.6 -0.6 1.3 -1.0 0.5
Illnesses of father: Heart disease 0.5 0.8 1.8 0.3 -1.0 -0.3 1.4
Illnesses of siblings: Diabetes 0.2 0.3 0.4 0.6 -0.5 0.6 0.4
Smoking status: Previous 0.3 0.5 1.0 0.3 -0.5 -0.8 1.0
Forced expiratory volume in 1-second (FEV1), predicted 1.5 3.0 5.8 -2.4 -2.4 0.4 -0.7
Whole body fat-free mass 0.0 0.1 0.4 0.1 -0.6 0.0 -0.4
Leg fat-free mass (right) 0.0 0.1 0.3 0.1 0.1 0.2 -0.6
Arm fat percentage (left) 0.4 1.6 3.8 1.0 -1.2 0.1 1.9
Average weekly red wine intake 0.8 1.1 3.1 1.0 0.4 -1.8 -0.4
Handedness (chirality/laterality): Left-handed 0.4 0.5 1.2 0.2 1.1 -0.5 0.8
Mood swings 1.0 1.8 3.6 -1.9 -0.1 -1.8 0.2
Loneliness, isolation 0.7 0.9 3.4 -1.8 0.0 -0.5 -0.3
Long-standing illness, disability or infirmity 5.1 7.7 17.4 0.4 -4.2 -1.1 3.5
Ever had bowel cancer screening 1.1 1.3 4.8 -2.2 0.0 0.0 -0.5
Diabetes diagnosed by doctor 1.7 2.8 8.7 0.7 -1.4 -0.4 3.0
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.5 1.4 1.2 -0.3 0.5 0.5
Friendships satisfaction 2.1 2.6 7.0 1.3 0.0 -2.7 1.3
Qualifications: nursing, teaching 0.5 0.8 1.0 -1.0 0.4 1.0 -1.0
Commuting to job workplace: Walk 0.7 0.7 2.4 -0.1 1.5 0.6 -0.4
Eye problems/disorders: Cataract 0.5 0.5 1.0 0.3 -0.9 1.0 0.6
Mouth/teeth dental problems: Mouth ulcers 0.4 0.6 1.9 0.3 -0.4 -1.4 0.5
Medication for cholesterol 1.8 2.7 5.5 -2.3 -0.7 -1.4 -1.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.3 0.7 -0.1 -0.8 0.7 -0.1
Back pain experienced in last month 0.3 0.4 0.7 -0.8 -0.8 0.1 -0.4
Mineral and other dietary supplements 0.3 0.4 0.8 -0.9 0.8 -0.1 0.5
Breast cancer (self-reported) 0.3 0.4 0.8 -0.8 0.9 0.3 0.1
Asthma (self-reported) 0.4 0.7 1.6 -0.4 -1.0 0.0 -1.3
Osteoporosis (self-reported) 0.3 0.3 1.0 -0.3 -0.1 -0.4 1.0
Osteoarthritis (self-reported) 0.4 0.6 1.9 0.6 -1.4 0.2 -0.0
Medication: Aspirin 2.4 3.1 5.3 2.3 -0.2 -1.3 2.3
Medication: Gliclazide 1.0 1.2 3.4 -0.6 -1.9 0.6 0.6
Illnesses of father: None of the above (group 1) 0.6 0.7 1.1 -1.1 1.0 0.6 -0.7
Smoking status: Current 0.3 0.5 1.3 0.1 1.2 0.8 -0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.6 5.5 11.3 -0.6 3.4 0.3 -3.2
Whole body water mass 0.0 0.1 0.3 0.2 -0.5 0.2 -0.5
Leg predicted mass (right) 0.0 0.1 0.2 0.2 0.0 0.2 -0.5
Arm fat mass (left) 0.2 0.9 1.8 0.7 -1.0 0.3 1.4
Number of self-reported non-cancer illnesses 1.2 2.0 4.2 0.1 -2.1 -1.1 1.7
Average weekly champagne plus white wine intake 1.7 2.3 7.5 0.6 2.7 0.2 -1.1
Miserableness 1.2 2.1 3.2 -1.1 -1.8 -1.8 1.0
Guilty feelings 0.7 1.0 2.5 -0.9 -0.9 0.2 1.6
Wears glasses or contact lenses 0.6 0.7 1.1 -0.8 -0.5 -0.8 -1.1
Ever taken oral contraceptive pill 1.0 1.1 2.7 1.0 1.6 0.8 -0.4
Hearing aid user 2.0 2.3 4.7 0.8 -2.2 -0.5 1.9
Mother’s age at death 0.7 0.8 1.7 -0.7 0.2 -1.0 -1.3
Financial situation satisfaction 2.0 2.5 3.6 0.8 -1.9 -1.7 1.7
Tinnitus: Yes, now most or all of the time 0.2 0.2 0.4 -0.0 -0.6 -0.7 0.2
Commuting to job workplace: Public transport 0.3 0.4 1.2 1.1 -0.3 -0.5 0.2
Eye problems/disorders: Glaucoma 1.0 1.2 3.5 -0.9 -1.9 0.3 0.6
Medication: Blood pressure 1.5 2.8 5.0 1.8 2.2 1.6 0.6
Pain type(s) experienced in last month: Hip pain 2.6 3.3 6.8 2.6 -0.7 -0.5 2.4
Supplements: Fish oil (including cod liver oil) 0.4 0.5 1.3 0.4 -1.1 0.1 -0.6
High cholesterol (Self-reported) 0.3 0.5 1.3 0.9 -0.2 0.2 1.1
Medication: Bendroflumethiazide 0.1 0.2 0.3 0.6 0.5 -0.0 0.1
Medication: Paracetamol 0.5 0.8 1.9 -1.1 0.0 0.0 1.4
Medication: Lisinopril 2.5 3.3 7.3 2.7 -0.6 0.9 2.1
Medication: Atorvastatin 0.6 0.8 2.7 -0.0 -0.0 -0.6 1.6
Illnesses of father: High blood pressure 0.4 0.5 1.0 -0.3 0.3 1.0 -0.9
Alcohol drinker status: Never 1.0 1.2 1.7 -1.0 -1.3 -0.6 1.3
Ever smoked 0.8 1.5 2.3 -0.6 1.5 -1.1 -1.5
Basal metabolic rate 0.0 0.2 0.9 0.1 -0.9 0.1 -0.1
Leg fat percentage (left) 1.0 3.5 8.6 0.9 -2.1 -0.2 2.9
Arm fat-free mass (left) 0.0 0.2 0.7 0.3 -0.9 -0.1 0.1
Number of operations (self-reported) 3.3 4.8 11.6 0.4 -3.4 -1.6 2.2
Average weekly beer plus cider intake 0.3 0.5 1.4 0.5 0.6 1.2 0.3
Irritability 0.6 1.0 3.3 -1.8 0.6 -0.7 -0.2
Risk taking 0.2 0.3 0.9 1.0 0.0 -0.5 0.1
Ever had prostate specific antigen (PSA) test 1.0 1.2 4.3 -0.1 -0.5 -2.1 0.2
Fractured/broken bones in last 5 years 0.6 0.7 2.4 0.3 0.4 1.5 0.5
Age started oral contraceptive pill 0.7 0.9 1.8 -0.9 -0.9 -1.4 -0.2
Diastolic blood pressure, automated reading 0.6 1.8 5.6 -0.7 0.5 2.4 -0.9
Ever depressed for a whole week 1.0 1.2 2.9 -1.7 1.0 -0.6 -0.7
Unable to work because of sickness or disability 1.1 1.4 3.0 1.7 -0.5 -0.6 1.5
Commuting to job workplace: Cycle 0.4 0.5 1.0 0.7 -0.4 -1.0 -0.4
Myopia 1.0 1.5 5.1 -1.0 -0.0 0.0 -2.2
Vascular/heart problems diagnosed by doctor 0.6 1.7 2.6 -1.6 -0.6 -1.1 -1.6
Cholesterol lowering medication 0.4 0.5 0.8 0.7 0.4 0.9 0.9
Medication: Omeprazole (e.g. Zanprol) 1.0 1.2 2.5 0.5 0.6 1.2 1.6
Pain experienced in last month 0.7 1.1 2.2 0.5 1.5 -1.4 -0.6
Supplements: Calcium 0.6 0.6 1.0 -0.7 -1.0 0.8 0.7
Basal cell carcinoma (self-reported) 0.7 0.9 3.0 1.7 -0.1 0.5 0.5
Heart attack/myocardial infarction (self-reported) 2.4 3.1 4.0 1.4 1.9 2.0 1.6
Deep venous thrombosis (DVT) (self-reported) 1.8 2.3 7.1 0.7 -2.7 0.6 1.1
Heart disease (siblings) 2.1 2.6 5.9 1.8 -0.1 -1.1 2.4
Alcohol drinker status: Previous 0.6 0.6 1.7 0.9 1.3 -0.0 -0.2
Pack years of smoking 0.9 1.3 5.0 -0.4 0.1 2.2 -0.2
Impedance of whole body 1.2 6.2 17.0 -1.9 -4.1 -0.5 2.0
Leg fat mass (left) 0.4 1.7 3.5 0.8 -1.6 0.0 1.9
Arm predicted mass (left) 0.0 0.2 0.7 0.1 -0.8 -0.0 0.1