Hub : Traits :

Mouth/teeth dental problems: Loose teeth

11 significantly associated models · 2 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 12 27587038 29432481 2 1 2.4e-09 9.1e-08 0.38 97 CCDC91

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Heel T-Score 7.4 1 1 3 0 1 CCDC91
BMI 2.3 1 0 0 0 1 CCDC91
Height 24.6 1 1 3 0 1 CCDC91
Lung FVC 31.4 1 1 3 0 1 CCDC91
Hand grip strength (left) 3.2 1 0 0 0 1 CCDC91
Impedance of leg (right) 1.8 1 0 0 0 1 CCDC91
Leg fat-free mass (left) 5.3 1 1 3 0 1 CCDC91
Sitting height 10.6 1 1 3 0 1 CCDC91
Impedance of leg (left) 2.6 1 0 0 0 1 CCDC91
Leg predicted mass (left) 5.4 1 1 3 0 1 CCDC91
Trunk fat mass 3.3 1 0 0 0 1 CCDC91
Weight 4.8 1 0 0 0 1 CCDC91
Impedance of arm (right) 1.9 1 0 0 0 1 CCDC91
Trunk fat-free mass 9.6 1 1 3 0 1 CCDC91
Hip circumference 2.9 1 0 0 0 1 CCDC91
Trunk predicted mass 9.7 1 1 3 0 1 CCDC91
Standing height 25.3 1 1 3 0 1 CCDC91
Arm fat-free mass (right) 7.2 1 1 3 0 1 CCDC91
Arm predicted mass (right) 7.4 1 1 3 0 1 CCDC91
Comparative height size at age 10 29.2 1 1 3 0 1 CCDC91
Forced expiratory volume in 1-second (FEV1), predicted 24.6 1 1 3 0 1 CCDC91
Whole body fat-free mass 8.4 1 1 3 0 1 CCDC91
Leg fat-free mass (right) 5.7 1 1 3 0 1 CCDC91
Forced expiratory volume in 1-second (FEV1), predicted percentage 11.9 1 0 0 0 1 CCDC91
Whole body water mass 8.1 1 1 3 0 1 CCDC91
Leg predicted mass (right) 5.7 1 1 3 0 1 CCDC91
Basal metabolic rate 7.9 1 1 3 0 1 CCDC91
Arm fat-free mass (left) 8.0 1 1 3 0 1 CCDC91
Myopia 6.4 1 0 0 0 1 CCDC91
Impedance of whole body 2.5 1 0 0 0 1 CCDC91
Arm predicted mass (left) 8.3 1 1 3 0 1 CCDC91

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.15
GTEx Adipose Visceral Omentum 0 0.0000 1.15
GTEx Adrenal Gland 0 0.0000 1.27
GTEx Artery Aorta 1 0.0336 1.23
GTEx Artery Coronary 0 0.0000 1.20
GTEx Artery Tibial 1 0.0266 1.18
GTEx Brain Caudate basal ganglia 0 0.0000 1.24
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.24
GTEx Brain Cerebellum 0 0.0000 1.29
GTEx Brain Cortex 0 0.0000 1.27
GTEx Brain Frontal Cortex BA9 0 0.0000 1.18
GTEx Brain Hippocampus 0 0.0000 1.33
GTEx Brain Hypothalamus 0 0.0000 1.12
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.26
GTEx Brain Putamen basal ganglia 0 0.0000 1.20
GTEx Breast Mammary Tissue 0 0.0000 1.19
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.19
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.17
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.21
GTEx Cells Transformed fibroblasts 1 0.0238 1.21
GTEx Colon Sigmoid 0 0.0000 1.24
GTEx Colon Transverse 2 0.0969 1.19
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.19
GTEx Esophagus Mucosa 0 0.0000 1.22
GTEx Esophagus Muscularis 1 0.0309 1.23
GTEx Heart Atrial Appendage 1 0.0633 1.32
GTEx Heart Left Ventricle 0 0.0000 1.18
GTEx Liver 0 0.0000 1.18
GTEx Lung 0 0.0000 1.16
GTEx Muscle Skeletal 0 0.0000 1.19
GTEx Nerve Tibial 0 0.0000 1.18
GTEx Ovary 0 0.0000 1.25
GTEx Pancreas 0 0.0000 1.21
GTEx Pituitary 0 0.0000 1.22
GTEx Prostate 0 0.0000 1.26
GTEx Skin Not Sun Exposed Suprapubic 1 0.0407 1.18
GTEx Skin Sun Exposed Lower leg 1 0.0275 1.18
GTEx Small Intestine Terminal Ileum 0 0.0000 1.27
GTEx Spleen 0 0.0000 1.13
GTEx Stomach 0 0.0000 1.18
GTEx Testis 0 0.0000 1.19
GTEx Thyroid 0 0.0000 1.14
GTEx Uterus 0 0.0000 1.37
GTEx Vagina 0 0.0000 1.30
GTEx Whole Blood 0 0.0000 1.22
METSIM Adipose 0 0.0000 1.12
NTR Blood 1 0.0416 1.20
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.18
YFS Blood 0 0.0000 1.15
CommonMind Brain Pre-frontal Cortex 1 0.0186 1.18
TCGA Breast Tumor 0 0.0000 1.21
TCGA Breast Normal 0 0.0000 1.16
TCGA Ovarian Tumor 0 0.0000 1.10
TCGA Prostate Tumor 0 0.0000 1.17