[Hub]/) : Traits : Vascular/heart problems diagnosed by doctor : ← →

chr16:29,711,343-31,833,122

Best TWAS P=1.2e-10 · Best GWAS P=8.93e-11 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	KAT8	0.06	0.07	lasso	1	0.07	3.9e-09	6.0	-6.0	2.0e-09	-0.69	0.04	0.96	FALSE
2	CommonMind	Brain Pre-frontal Cortex	VKORC1	0.03	0.04	lasso	3	0.03	4.9e-05	6.3	6.4	1.2e-10	0.97	0.00	0.99	TRUE
3	CommonMind	Brain Pre-frontal Cortex	ZNF646	0.04	0.06	lasso	7	0.04	4.5e-06	5.6	-6.0	1.7e-09	-0.70	0.16	0.84	FALSE
4	GTEx	Adipose Subcutaneous	KAT8	0.19	0.17	lasso	5	0.25	4.8e-20	-3.9	-5.3	1.1e-07	-0.54	0.85	0.15	FALSE
5	GTEx	Adipose Visceral Omentum	KAT8	0.07	0.02	lasso	5	0.02	4.0e-02	6.0	-6.0	2.2e-09	-0.65	0.05	0.88	FALSE
6	GTEx	Adrenal Gland	KAT8	0.11	0.06	enet	11	0.07	1.8e-03	5.8	-5.6	2.2e-08	-0.67	0.08	0.71	FALSE
7	GTEx	Artery Aorta	KAT8	0.23	0.20	lasso	4	0.20	2.7e-11	6.0	-6.0	1.5e-09	-0.66	0.05	0.95	FALSE
8	GTEx	Artery Coronary	KAT8	0.22	0.19	lasso	2	0.19	6.6e-07	6.0	-6.0	1.7e-09	-0.68	0.05	0.91	FALSE
9	GTEx	Artery Tibial	KAT8	0.30	0.23	lasso	5	0.27	3.3e-21	-3.9	-5.5	3.7e-08	-0.56	0.71	0.29	FALSE
10	GTEx	Brain Cerebellar Hemisphere	KAT8	0.12	0.23	lasso	3	0.18	2.9e-05	6.0	-6.1	1.4e-09	-0.72	0.03	0.87	FALSE
11	GTEx	Brain Cerebellum	KAT8	0.21	0.01	lasso	9	0.05	1.4e-02	6.0	-6.3	3.0e-10	-0.58	0.06	0.76	FALSE
12	GTEx	Brain Cortex	KAT8	0.14	0.14	lasso	3	0.10	8.9e-04	5.0	-5.6	1.8e-08	-0.78	0.04	0.78	FALSE
13	GTEx	Brain Frontal Cortex BA9	KAT8	0.16	0.20	lasso	1	0.17	2.6e-05	5.9	-5.9	2.7e-09	-0.70	0.05	0.83	FALSE
14	GTEx	Brain Nucleus accumbens basal ganglia	KAT8	0.19	0.13	lasso	4	0.18	1.4e-05	6.0	-5.8	8.6e-09	-0.59	0.04	0.72	FALSE
15	GTEx	Breast Mammary Tissue	KAT8	0.23	0.14	lasso	10	0.17	4.4e-09	6.0	-5.8	8.4e-09	-0.61	0.05	0.95	FALSE
16	GTEx	Colon Sigmoid	KAT8	0.20	0.10	lasso	3	0.14	1.0e-05	6.0	-5.8	8.2e-09	-0.59	0.05	0.82	FALSE
17	GTEx	Esophagus Gastroesophageal Junction	KAT8	0.18	0.11	lasso	4	0.24	4.9e-09	-3.9	-5.6	1.9e-08	-0.60	0.17	0.81	FALSE
18	GTEx	Esophagus Mucosa	BCKDK	0.05	0.05	enet	6	0.06	8.7e-05	5.7	5.7	1.5e-08	0.78	0.03	0.94	FALSE
19	GTEx	Esophagus Mucosa	KAT8	0.21	0.15	lasso	4	0.23	3.5e-15	-3.9	-5.7	1.5e-08	-0.57	0.21	0.79	FALSE
20	GTEx	Esophagus Muscularis	KAT8	0.29	0.19	lasso	4	0.21	1.2e-12	-3.9	-5.4	7.6e-08	-0.52	0.47	0.53	FALSE
21	GTEx	Liver	PRSS53	0.22	0.08	lasso	5	0.11	5.5e-04	5.7	-6.1	8.4e-10	-0.71	0.07	0.73	FALSE
22	GTEx	Liver	VKORC1	0.22	0.20	lasso	5	0.22	1.1e-06	5.7	-5.8	5.3e-09	-0.72	0.06	0.93	FALSE
23	GTEx	Lung	KAT8	0.14	0.08	lasso	3	0.12	1.7e-09	6.0	-6.0	2.3e-09	-0.60	0.06	0.94	FALSE
24	GTEx	Nerve Tibial	KAT8	0.17	0.06	enet	24	0.08	3.0e-06	-3.9	-6.0	2.1e-09	-0.61	0.06	0.94	FALSE
25	GTEx	Ovary	KAT8	0.16	0.09	lasso	4	0.06	1.2e-02	6.0	-6.0	1.9e-09	-0.65	0.05	0.67	FALSE
26	GTEx	Prostate	KAT8	0.19	0.09	lasso	3	0.13	3.8e-04	6.0	-6.1	8.6e-10	-0.73	0.03	0.68	FALSE
27	GTEx	Skin Not Sun Exposed Suprapubic	KAT8	0.30	0.20	enet	15	0.26	1.9e-14	-3.9	-5.8	5.9e-09	-0.60	0.11	0.89	FALSE
28	GTEx	Skin Sun Exposed Lower leg	KAT8	0.31	0.23	lasso	6	0.35	2.2e-30	6.0	-5.7	1.3e-08	-0.59	0.05	0.95	FALSE
29	GTEx	Small Intestine Terminal Ileum	VKORC1	0.30	0.05	enet	18	0.12	1.4e-03	5.9	-5.6	2.5e-08	-0.53	0.04	0.40	FALSE
30	GTEx	Stomach	KAT8	0.12	0.03	lasso	5	0.07	2.9e-04	-3.9	-5.6	1.6e-08	-0.58	0.12	0.82	FALSE
31	GTEx	Thyroid	KAT8	0.21	0.12	lasso	6	0.15	2.2e-11	5.9	-5.9	3.8e-09	-0.64	0.04	0.96	FALSE
32	GTEx	Uterus	FBRS	0.21	0.07	lasso	10	0.07	1.7e-02	5.6	5.3	1.4e-07	0.73	0.03	0.54	FALSE
33	GTEx	Whole Blood	HSD3B7	0.06	0.06	lasso	4	0.06	2.6e-06	5.9	6.0	1.9e-09	0.72	0.06	0.94	FALSE
34	GTEx	Whole Blood	ZNF668	0.05	0.06	lasso	3	0.06	5.9e-06	5.9	5.9	4.1e-09	0.66	0.05	0.95	FALSE
35	METSIM	Adipose	KAT8	0.17	0.13	lasso	6	0.20	1.7e-28	5.9	-5.6	1.8e-08	-0.58	0.05	0.95	FALSE
36	NTR	Blood	ZNF48	0.01	0.00	blup	196	0.00	2.2e-02	-1.1	5.6	1.7e-08	0.54	0.04	0.06	FALSE
37	ROSMAP	Brain Pre-frontal Cortex	KAT8	0.13	0.16	lasso	5	0.16	4.2e-20	6.0	-6.1	1.2e-09	-0.68	0.04	0.96	FALSE
38	ROSMAP	Brain Pre-frontal Cortex	ZNF668	0.11	0.11	lasso	4	0.11	1.7e-14	5.7	5.7	1.6e-08	0.68	0.10	0.90	FALSE
39	ROSMAP	Brain Pre-frontal Cortex	ZNF646	0.06	0.01	bslmm	233	0.01	1.1e-02	5.8	-5.9	4.6e-09	-0.64	0.06	0.92	FALSE
40	YFS	Blood	HSD3B7	0.06	0.02	blup	220	0.03	8.9e-10	6.1	5.7	1.2e-08	0.52	0.05	0.95	FALSE
41	YFS	Blood	VKORC1	0.08	0.04	enet	20	0.07	2.7e-23	5.7	5.1	2.8e-07	0.54	0.13	0.87	FALSE
42	YFS	Blood	ZNF668	0.10	0.12	bslmm	232	0.12	1.5e-36	5.7	5.9	4.4e-09	0.69	0.14	0.86	FALSE
43	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	MYST1	0.04	0.03	enet	4	0.03	1.2e-03	-3.9	-5.3	1.5e-07	-0.50	0.04	0.76	FALSE
44	The Cancer Genome Atlas	Breast Invasive Carcinoma	FAM57B	0.04	0.01	blup	46	0.03	2.6e-07	-4.6	-5.6	1.8e-08	-0.14	0.02	0.96	TRUE
45	The Cancer Genome Atlas	Breast Invasive Carcinoma	MYST1	0.05	0.04	blup	34	0.08	2.1e-15	-3.9	-5.2	2.1e-07	-0.54	0.43	0.57	FALSE
46	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	MYST1	0.26	0.01	blup	34	0.05	1.4e-03	6.0	-6.2	6.5e-10	-0.51	0.01	0.63	FALSE
47	The Cancer Genome Atlas	Glioblastoma Multiforme	MYST1	0.18	0.07	blup	35	0.11	4.2e-04	5.7	-5.4	6.3e-08	-0.68	0.02	0.90	FALSE
48	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	HSD3B7	0.06	0.01	blup	31	0.02	7.4e-04	-3.6	-5.3	1.2e-07	-0.60	0.05	0.75	FALSE
49	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ZNF668	0.03	0.01	lasso	3	0.01	2.5e-02	5.7	5.8	6.3e-09	0.69	0.02	0.76	FALSE
50	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MYST1	0.12	0.09	blup	34	0.10	2.8e-11	-3.9	-5.1	2.8e-07	-0.51	0.86	0.14	FALSE
51	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	VKORC1	0.03	0.04	lasso	3	0.04	3.2e-05	5.6	-5.9	4.9e-09	-0.71	0.02	0.98	FALSE
52	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ZNF668	0.02	0.02	blup	32	0.02	2.9e-03	5.7	5.9	3.5e-09	0.69	0.02	0.93	FALSE
53	The Cancer Genome Atlas	Brain Lower Grade Glioma	MYST1	0.16	0.08	blup	34	0.12	1.5e-13	6.0	-5.7	1.5e-08	-0.57	0.01	0.99	FALSE
54	The Cancer Genome Atlas	Brain Lower Grade Glioma	ZNF668	0.02	0.01	enet	8	0.02	3.1e-03	5.7	5.7	1.0e-08	0.67	0.02	0.83	FALSE
55	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	YPEL3	0.15	0.00	blup	20	0.05	2.9e-03	-4.0	-5.1	3.0e-07	-0.11	0.00	0.01	FALSE
56	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	MYST1	0.03	0.05	blup	34	0.03	2.1e-03	5.7	-5.9	3.3e-09	-0.69	0.02	0.92	FALSE
57	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	MYST1	0.22	0.15	blup	36	0.21	2.1e-09	6.1	-5.3	1.2e-07	-0.59	0.01	0.99	FALSE
58	The Cancer Genome Atlas	Prostate Adenocarcinoma	MYST1	0.19	0.12	blup	33	0.18	1.5e-18	6.0	-5.5	3.2e-08	-0.60	0.01	0.99	FALSE
59	The Cancer Genome Atlas	Rectum Adenocarcinoma	MYST1	0.13	0.05	blup	35	0.06	1.9e-02	6.1	-6.0	1.5e-09	-0.66	0.01	0.63	FALSE
60	The Cancer Genome Atlas	Stomach Adenocarcinoma	MYST1	0.04	0.02	blup	35	0.02	8.7e-03	-3.9	-5.3	1.1e-07	-0.56	0.02	0.46	FALSE
61	The Cancer Genome Atlas	Testicular Germ Cell Tumors	MYST1	0.13	0.06	blup	34	0.12	6.8e-05	5.9	-6.2	6.3e-10	-0.65	0.02	0.95	FALSE
62	The Cancer Genome Atlas	Thyroid Carcinoma	MYST1	0.12	0.10	lasso	3	0.14	1.1e-13	6.0	-5.8	6.9e-09	-0.59	0.01	0.99	FALSE