[Hub]/) : Traits : Vascular/heart problems diagnosed by doctor :

chr16:29,711,343-31,833,122

Best TWAS P=1.2e-10 · Best GWAS P=8.93e-11 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex KAT8 0.06 0.07 lasso 1 0.07 3.9e-09 6.0 -6.0 2.0e-09 -0.69 0.04 0.96 FALSE
2 CommonMind Brain Pre-frontal Cortex VKORC1 0.03 0.04 lasso 3 0.03 4.9e-05 6.3 6.4 1.2e-10 0.97 0.00 0.99 TRUE
3 CommonMind Brain Pre-frontal Cortex ZNF646 0.04 0.06 lasso 7 0.04 4.5e-06 5.6 -6.0 1.7e-09 -0.70 0.16 0.84 FALSE
4 GTEx Adipose Subcutaneous KAT8 0.19 0.17 lasso 5 0.25 4.8e-20 -3.9 -5.3 1.1e-07 -0.54 0.85 0.15 FALSE
5 GTEx Adipose Visceral Omentum KAT8 0.07 0.02 lasso 5 0.02 4.0e-02 6.0 -6.0 2.2e-09 -0.65 0.05 0.88 FALSE
6 GTEx Adrenal Gland KAT8 0.11 0.06 enet 11 0.07 1.8e-03 5.8 -5.6 2.2e-08 -0.67 0.08 0.71 FALSE
7 GTEx Artery Aorta KAT8 0.23 0.20 lasso 4 0.20 2.7e-11 6.0 -6.0 1.5e-09 -0.66 0.05 0.95 FALSE
8 GTEx Artery Coronary KAT8 0.22 0.19 lasso 2 0.19 6.6e-07 6.0 -6.0 1.7e-09 -0.68 0.05 0.91 FALSE
9 GTEx Artery Tibial KAT8 0.30 0.23 lasso 5 0.27 3.3e-21 -3.9 -5.5 3.7e-08 -0.56 0.71 0.29 FALSE
10 GTEx Brain Cerebellar Hemisphere KAT8 0.12 0.23 lasso 3 0.18 2.9e-05 6.0 -6.1 1.4e-09 -0.72 0.03 0.87 FALSE
11 GTEx Brain Cerebellum KAT8 0.21 0.01 lasso 9 0.05 1.4e-02 6.0 -6.3 3.0e-10 -0.58 0.06 0.76 FALSE
12 GTEx Brain Cortex KAT8 0.14 0.14 lasso 3 0.10 8.9e-04 5.0 -5.6 1.8e-08 -0.78 0.04 0.78 FALSE
13 GTEx Brain Frontal Cortex BA9 KAT8 0.16 0.20 lasso 1 0.17 2.6e-05 5.9 -5.9 2.7e-09 -0.70 0.05 0.83 FALSE
14 GTEx Brain Nucleus accumbens basal ganglia KAT8 0.19 0.13 lasso 4 0.18 1.4e-05 6.0 -5.8 8.6e-09 -0.59 0.04 0.72 FALSE
15 GTEx Breast Mammary Tissue KAT8 0.23 0.14 lasso 10 0.17 4.4e-09 6.0 -5.8 8.4e-09 -0.61 0.05 0.95 FALSE
16 GTEx Colon Sigmoid KAT8 0.20 0.10 lasso 3 0.14 1.0e-05 6.0 -5.8 8.2e-09 -0.59 0.05 0.82 FALSE
17 GTEx Esophagus Gastroesophageal Junction KAT8 0.18 0.11 lasso 4 0.24 4.9e-09 -3.9 -5.6 1.9e-08 -0.60 0.17 0.81 FALSE
18 GTEx Esophagus Mucosa BCKDK 0.05 0.05 enet 6 0.06 8.7e-05 5.7 5.7 1.5e-08 0.78 0.03 0.94 FALSE
19 GTEx Esophagus Mucosa KAT8 0.21 0.15 lasso 4 0.23 3.5e-15 -3.9 -5.7 1.5e-08 -0.57 0.21 0.79 FALSE
20 GTEx Esophagus Muscularis KAT8 0.29 0.19 lasso 4 0.21 1.2e-12 -3.9 -5.4 7.6e-08 -0.52 0.47 0.53 FALSE
21 GTEx Liver PRSS53 0.22 0.08 lasso 5 0.11 5.5e-04 5.7 -6.1 8.4e-10 -0.71 0.07 0.73 FALSE
22 GTEx Liver VKORC1 0.22 0.20 lasso 5 0.22 1.1e-06 5.7 -5.8 5.3e-09 -0.72 0.06 0.93 FALSE
23 GTEx Lung KAT8 0.14 0.08 lasso 3 0.12 1.7e-09 6.0 -6.0 2.3e-09 -0.60 0.06 0.94 FALSE
24 GTEx Nerve Tibial KAT8 0.17 0.06 enet 24 0.08 3.0e-06 -3.9 -6.0 2.1e-09 -0.61 0.06 0.94 FALSE
25 GTEx Ovary KAT8 0.16 0.09 lasso 4 0.06 1.2e-02 6.0 -6.0 1.9e-09 -0.65 0.05 0.67 FALSE
26 GTEx Prostate KAT8 0.19 0.09 lasso 3 0.13 3.8e-04 6.0 -6.1 8.6e-10 -0.73 0.03 0.68 FALSE
27 GTEx Skin Not Sun Exposed Suprapubic KAT8 0.30 0.20 enet 15 0.26 1.9e-14 -3.9 -5.8 5.9e-09 -0.60 0.11 0.89 FALSE
28 GTEx Skin Sun Exposed Lower leg KAT8 0.31 0.23 lasso 6 0.35 2.2e-30 6.0 -5.7 1.3e-08 -0.59 0.05 0.95 FALSE
29 GTEx Small Intestine Terminal Ileum VKORC1 0.30 0.05 enet 18 0.12 1.4e-03 5.9 -5.6 2.5e-08 -0.53 0.04 0.40 FALSE
30 GTEx Stomach KAT8 0.12 0.03 lasso 5 0.07 2.9e-04 -3.9 -5.6 1.6e-08 -0.58 0.12 0.82 FALSE
31 GTEx Thyroid KAT8 0.21 0.12 lasso 6 0.15 2.2e-11 5.9 -5.9 3.8e-09 -0.64 0.04 0.96 FALSE
32 GTEx Uterus FBRS 0.21 0.07 lasso 10 0.07 1.7e-02 5.6 5.3 1.4e-07 0.73 0.03 0.54 FALSE
33 GTEx Whole Blood HSD3B7 0.06 0.06 lasso 4 0.06 2.6e-06 5.9 6.0 1.9e-09 0.72 0.06 0.94 FALSE
34 GTEx Whole Blood ZNF668 0.05 0.06 lasso 3 0.06 5.9e-06 5.9 5.9 4.1e-09 0.66 0.05 0.95 FALSE
35 METSIM Adipose KAT8 0.17 0.13 lasso 6 0.20 1.7e-28 5.9 -5.6 1.8e-08 -0.58 0.05 0.95 FALSE
36 NTR Blood ZNF48 0.01 0.00 blup 196 0.00 2.2e-02 -1.1 5.6 1.7e-08 0.54 0.04 0.06 FALSE
37 ROSMAP Brain Pre-frontal Cortex KAT8 0.13 0.16 lasso 5 0.16 4.2e-20 6.0 -6.1 1.2e-09 -0.68 0.04 0.96 FALSE
38 ROSMAP Brain Pre-frontal Cortex ZNF668 0.11 0.11 lasso 4 0.11 1.7e-14 5.7 5.7 1.6e-08 0.68 0.10 0.90 FALSE
39 ROSMAP Brain Pre-frontal Cortex ZNF646 0.06 0.01 bslmm 233 0.01 1.1e-02 5.8 -5.9 4.6e-09 -0.64 0.06 0.92 FALSE
40 YFS Blood HSD3B7 0.06 0.02 blup 220 0.03 8.9e-10 6.1 5.7 1.2e-08 0.52 0.05 0.95 FALSE
41 YFS Blood VKORC1 0.08 0.04 enet 20 0.07 2.7e-23 5.7 5.1 2.8e-07 0.54 0.13 0.87 FALSE
42 YFS Blood ZNF668 0.10 0.12 bslmm 232 0.12 1.5e-36 5.7 5.9 4.4e-09 0.69 0.14 0.86 FALSE
43 The Cancer Genome Atlas Bladder Urothelial Carcinoma MYST1 0.04 0.03 enet 4 0.03 1.2e-03 -3.9 -5.3 1.5e-07 -0.50 0.04 0.76 FALSE
44 The Cancer Genome Atlas Breast Invasive Carcinoma FAM57B 0.04 0.01 blup 46 0.03 2.6e-07 -4.6 -5.6 1.8e-08 -0.14 0.02 0.96 TRUE
45 The Cancer Genome Atlas Breast Invasive Carcinoma MYST1 0.05 0.04 blup 34 0.08 2.1e-15 -3.9 -5.2 2.1e-07 -0.54 0.43 0.57 FALSE
46 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma MYST1 0.26 0.01 blup 34 0.05 1.4e-03 6.0 -6.2 6.5e-10 -0.51 0.01 0.63 FALSE
47 The Cancer Genome Atlas Glioblastoma Multiforme MYST1 0.18 0.07 blup 35 0.11 4.2e-04 5.7 -5.4 6.3e-08 -0.68 0.02 0.90 FALSE
48 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma HSD3B7 0.06 0.01 blup 31 0.02 7.4e-04 -3.6 -5.3 1.2e-07 -0.60 0.05 0.75 FALSE
49 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma ZNF668 0.03 0.01 lasso 3 0.01 2.5e-02 5.7 5.8 6.3e-09 0.69 0.02 0.76 FALSE
50 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma MYST1 0.12 0.09 blup 34 0.10 2.8e-11 -3.9 -5.1 2.8e-07 -0.51 0.86 0.14 FALSE
51 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma VKORC1 0.03 0.04 lasso 3 0.04 3.2e-05 5.6 -5.9 4.9e-09 -0.71 0.02 0.98 FALSE
52 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma ZNF668 0.02 0.02 blup 32 0.02 2.9e-03 5.7 5.9 3.5e-09 0.69 0.02 0.93 FALSE
53 The Cancer Genome Atlas Brain Lower Grade Glioma MYST1 0.16 0.08 blup 34 0.12 1.5e-13 6.0 -5.7 1.5e-08 -0.57 0.01 0.99 FALSE
54 The Cancer Genome Atlas Brain Lower Grade Glioma ZNF668 0.02 0.01 enet 8 0.02 3.1e-03 5.7 5.7 1.0e-08 0.67 0.02 0.83 FALSE
55 The Cancer Genome Atlas Liver Hepatocellular Carcinoma YPEL3 0.15 0.00 blup 20 0.05 2.9e-03 -4.0 -5.1 3.0e-07 -0.11 0.00 0.01 FALSE
56 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma MYST1 0.03 0.05 blup 34 0.03 2.1e-03 5.7 -5.9 3.3e-09 -0.69 0.02 0.92 FALSE
57 The Cancer Genome Atlas Pancreatic Adenocarcinoma MYST1 0.22 0.15 blup 36 0.21 2.1e-09 6.1 -5.3 1.2e-07 -0.59 0.01 0.99 FALSE
58 The Cancer Genome Atlas Prostate Adenocarcinoma MYST1 0.19 0.12 blup 33 0.18 1.5e-18 6.0 -5.5 3.2e-08 -0.60 0.01 0.99 FALSE
59 The Cancer Genome Atlas Rectum Adenocarcinoma MYST1 0.13 0.05 blup 35 0.06 1.9e-02 6.1 -6.0 1.5e-09 -0.66 0.01 0.63 FALSE
60 The Cancer Genome Atlas Stomach Adenocarcinoma MYST1 0.04 0.02 blup 35 0.02 8.7e-03 -3.9 -5.3 1.1e-07 -0.56 0.02 0.46 FALSE
61 The Cancer Genome Atlas Testicular Germ Cell Tumors MYST1 0.13 0.06 blup 34 0.12 6.8e-05 5.9 -6.2 6.3e-10 -0.65 0.02 0.95 FALSE
62 The Cancer Genome Atlas Thyroid Carcinoma MYST1 0.12 0.10 lasso 3 0.14 1.1e-13 6.0 -5.8 6.9e-09 -0.59 0.01 0.99 FALSE