TWAS hub - ZNF48

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0134	0.0074	0.0150	-0.001	0.003	0.000	0.003	-0.001	0.880	0.022	0.24	0.027	0.560
2	TCGA	Pheochromocytoma and Paraganglioma	0.0900	0.0540	0.0062	0.034	0.010	-0.005	NA	0.022	0.017	0.120	0.57	NA	0.043

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Waist circumference	13.4	49.0	83.5	-9.1	3.8
Alcohol intake frequency.	12.7	29.6	45.4	-6.7	3.7
Medication: Bendroflumethiazide	12.5	19.0	37.3	-6.1	0.8
Weight	10.4	51.2	85.9	-9.3	4.1
Hip circumference	9.6	41.4	71.7	-8.5	3.3
Arm fat mass (right)	9.6	39.4	70.7	-8.4	2.8
Comparative body size at age 10	9.6	26.4	48.4	-7.0	2.1
Leg fat mass (left)	9.3	36.4	65.4	-8.1	2.7
Body mass index (BMI)	9.1	38.8	72.8	-8.5	2.2
Arm fat mass (left)	9.1	37.5	68.2	-8.3	2.6
Nervous feelings	8.8	16.4	17.3	4.2	-3.9
BMI	8.5	49.2	87.8	-9.4	3.3
Whole body fat mass	8.4	34.9	61.5	-7.8	2.9
Leg fat mass (right)	8.3	32.1	58.2	-7.6	2.5
Blood White Count	7.5	55.3	106.1	10.3	-2.1
Trunk fat mass	7.5	32.0	54.2	-7.4	3.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	7.5	15.9	25.8	5.1	-2.5
Leg fat percentage (left)	7.2	26.2	47.7	-6.9	2.1
Arm predicted mass (left)	7.0	35.6	58.1	-7.6	3.6
Worry (Nagel 2018)	6.9	14.4	15.8	3.6	-4.0
Arm fat percentage (right)	6.7	26.6	48.3	-7.0	2.2
Arm fat-free mass (right)	6.6	33.8	56.7	-7.5	3.3
Arm fat percentage (left)	6.6	26.5	48.4	-7.0	2.1
Basal metabolic rate	6.6	36.4	61.2	-7.8	3.4
Arm fat-free mass (left)	6.5	32.9	55.4	-7.4	3.2
Arm predicted mass (right)	6.4	32.5	55.1	-7.4	3.1
High blood pressure	6.2	17.4	34.2	-5.8	0.8
Body fat percentage	6.2	24.6	43.3	-6.6	2.4
Vascular/heart problems diagnosed by doctor	6.0	16.4	31.8	5.6	-0.9
Alzheimer’s Disease (including proxy)	5.7	8.2	12.4	3.5	-2.0
Diabetes (mother)	5.7	7.3	11.6	-3.4	1.7
Hypertension (Self-reported)	5.7	15.8	30.8	-5.5	0.9
Leg predicted mass (right)	5.7	30.4	51.7	-7.2	3.0
Frequency of tenseness / restlessness in last 2 weeks	5.6	8.7	14.0	3.7	-1.9
Leg fat percentage (right)	5.6	20.2	37.1	-6.1	1.8
Leg fat-free mass (right)	5.6	30.0	51.4	-7.2	2.9
Leg fat-free mass (left)	5.5	29.3	50.8	-7.1	2.8
Leg predicted mass (left)	5.5	28.9	50.1	-7.1	2.8
Whole body fat-free mass	5.5	31.4	52.1	-7.2	3.3
Whole body water mass	5.5	31.3	52.1	-7.2	3.2
Trunk fat percentage	5.3	21.3	36.7	-6.1	2.4
Hayfever/allergic rhinitis (self-reported)	4.9	6.5	10.0	1.7	-3.2
Trunk fat-free mass	4.9	28.4	44.1	-6.6	3.6
Trunk predicted mass	4.9	28.2	43.6	-6.6	3.6
Rheumatoid Arthritis	4.8	6.6	10.7	-3.3	1.6
Worrier / anxious feelings	4.6	8.8	10.8	2.6	-3.3
Medication for cholesterol	4.6	6.9	13.4	3.7	-0.7
Primary Biliary Cirrhosis	4.4	6.3	9.2	-3.0	-1.8
Cardiovascular Disease	4.4	14.4	28.7	-5.4	0.2
Medication: Blood pressure	4.3	8.2	16.3	-4.0	0.4
Cholesterol lowering medication	4.2	6.2	12.3	-3.5	0.4
Impedance of leg (right)	4.0	19.4	37.1	6.1	-1.3
Suffer from ‘nerves’	3.8	6.0	6.6	2.6	-2.3
Impedance of whole body	3.7	18.8	36.5	6.0	-1.1
Alzheimer’s Disease (in mother)	3.6	4.2	7.3	2.7	-1.0
Hand grip strength (left)	3.6	9.5	16.6	-4.1	1.5
Pain all over the body in last month	3.5	3.7	7.3	-2.7	-0.4
Impedance of arm (right)	3.5	16.3	31.6	5.6	-1.0
Impedance of arm (left)	3.5	16.1	30.9	5.6	-1.1
Medication: Blood pressure	3.5	6.2	10.9	-3.3	1.2
Number of treatments/medications taken	3.4	6.1	12.0	-3.5	0.3
Eye problems/disorders: None of the above	3.4	4.0	4.3	-2.1	-1.9
Qualifications: College or University degree	3.3	10.4	20.7	4.6	-0.1
Supplements: Vitamin C	3.3	4.0	4.0	2.0	2.0
Tense / ‘highly strung’	3.2	5.2	9.1	3.0	-1.1
Diastolic blood pressure, automated reading	3.2	10.0	19.1	-4.4	1.0
Neuroticism (Nagel 2018)	3.1	7.3	11.2	1.9	-3.3
Triglycerides	3.1	5.1	10.2	-3.2	0.0
Lung FVC	3.1	15.7	26.4	5.1	-2.2
Hand grip strength (right)	3.1	8.3	14.7	-3.8	1.4
Loud music exposure frequency	3.1	3.4	4.3	2.1	-1.6
Average weekly champagne plus white wine intake	3.1	4.3	7.6	2.8	-1.0
Medication for cholesterol, blood pressure or diabetes	3.0	5.0	8.3	2.9	-1.3
High cholesterol (Self-reported)	3.0	5.4	10.7	-3.3	-0.1
Number of incorrect matches in round	2.9	4.8	9.4	3.1	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	2.9	9.3	18.3	4.3	0.5
Mother’s age at death	2.9	3.6	7.1	-0.2	2.7
Impedance of leg (left)	2.8	13.7	27.0	5.2	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	2.8	6.5	10.0	3.2	-1.7
Medication: Ramipril	2.7	3.4	5.9	-2.4	1.0
Chronic bronchitis/emphysema (mother)	2.6	3.0	3.4	-1.6	-1.9
Ulcerative Colitis	2.5	3.6	7.2	-2.7	0.0
Illnesses of siblings	2.5	3.5	6.6	2.6	-0.6
Type 2 Diabetes (T2D) (2018)	2.4	4.6	5.9	-2.4	1.8
Hayfever, allergic rhinitis or eczema	2.4	5.3	8.2	2.9	-1.5
Family relationship satisfaction	2.4	3.0	4.0	2.0	1.4
Heel T-Score	2.3	18.5	33.8	5.8	-1.8
Alcohol intake versus 10 years previously	2.3	3.4	6.4	-2.5	0.6
Qualifications: NVQ or HND or HNC or equivalent	2.3	2.8	3.0	-1.7	1.6
Medication: Atorvastatin	2.3	2.8	4.3	-2.1	-1.2
Knee pain experienced in last month	2.2	3.5	4.2	-2.0	-1.7
Smoking status: Previous	2.2	3.3	5.3	1.1	-2.3
Tinnitus: Yes, now most or all of the time	2.2	2.5	4.8	-0.5	2.2
Neuroticism	2.1	5.2	8.6	1.3	-2.9
Heel bone mineral density (BMD) T-score, automated (left)	2.1	4.7	7.2	2.7	-1.5
Happiness	2.1	2.6	5.0	2.2	0.4
Mouth/teeth dental problems: Dentures	2.1	3.6	7.1	-2.7	0.2
Exposure to tobacco smoke at home	2.1	2.3	2.4	-1.5	1.6
Blood Red Count	2.0	19.0	24.8	5.0	3.6
Current tobacco smoking	2.0	3.3	4.7	-2.2	1.4
Pulse wave reflection index	2.0	2.5	4.5	-0.7	-2.1
Emphysema/chronic bronchitis	2.0	2.3	3.2	-1.2	-1.8
Medication: Co-codamol	1.9	2.2	4.4	-2.1	-0.1
Maternal smoking around birth	1.9	2.7	5.2	0.5	-2.3
Comparative height size at age 10	1.9	10.4	14.8	-2.4	3.9
Overall health rating	1.9	4.1	7.9	-2.8	0.5
Number of operations (self-reported)	1.9	2.9	3.7	-1.9	-1.4
Pain experienced in last month	1.9	3.2	4.7	2.2	1.3
Allergy or Eczema	1.8	4.8	7.7	2.8	-1.4
Chronic bronchitis/emphysema (father)	1.8	2.2	3.6	-1.9	-0.8
Birth weight of first child	1.8	3.2	6.4	-2.5	-0.2
Wheeze or whistling in the chest in last year	1.8	3.1	4.1	-2.0	-1.5
Blood Eosinophil Count	1.7	13.3	25.4	5.0	1.1
Medication for pain relief, constipation, heartburn	1.7	2.9	5.7	2.4	0.4
Neck or shoulder pain in last month	1.7	2.4	4.9	-2.2	-0.1
Basal cell carcinoma (self-reported)	1.7	2.1	4.1	2.0	0.1
Ulcerative Colitis (UC)	1.6	3.0	6.0	-2.5	-0.0
Lung FEV1/FVC ratio	1.6	8.2	16.4	4.0	-0.2
Chronotype (morning person)	1.6	3.6	5.4	-2.3	1.4
Sensitivity / hurt feelings	1.6	2.8	5.1	0.7	-2.3
Pulse wave Arterial Stiffness index	1.6	1.9	3.1	-1.8	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.6	1.9	1.9	-1.3	1.4
Long-standing illness, disability or infirmity	1.6	2.5	4.3	-2.1	0.8
Smoking status: Current	1.6	2.6	2.8	-1.6	1.7
Depressed Affect (Nagel 2018)	1.5	3.1	6.1	-0.3	-2.5
Height	1.5	29.2	30.5	-5.3	5.5
Average weekly fortified wine intake	1.5	1.7	2.9	1.7	-0.7
Serious illness, injury or assault to yourself	1.5	1.9	3.3	-0.6	1.8
Pulse wave peak to peak time	1.5	1.8	2.6	1.6	1.0
Age at last live birth	1.5	2.2	3.5	0.9	1.9
Number of self-reported non-cancer illnesses	1.5	2.5	4.4	-2.1	-0.8
Unable to work because of sickness or disability	1.5	1.9	3.7	-1.9	-0.3
Had menopause	1.4	1.8	2.0	-1.4	1.2
Qualifications: None of the above	1.4	2.9	4.7	-1.1	-2.2
Medication: Paracetamol	1.4	2.3	4.5	-2.1	-0.1
Headache pain in last month	1.4	2.3	3.6	-1.0	-1.9
High blood pressure (siblings)	1.4	2.0	4.0	-2.0	-0.1
Forced vital capacity (FVC), Best measure	1.4	5.0	9.6	3.1	0.6
Health satisfaction	1.4	1.9	2.4	-1.2	1.5
Illnesses of father: High blood pressure	1.4	1.8	3.0	0.7	-1.7
Medication: Omeprazole (e.g. Zanprol)	1.4	1.8	2.9	-0.8	-1.7
Schizophrenia (2018)	1.3	2.7	3.6	1.9	-1.4
Age at First Birth	1.3	1.9	3.8	2.0	0.0
Supplements: Zinc	1.3	1.4	1.7	1.3	1.1
Allergy	1.3	2.9	3.0	-1.7	1.7
Neuroticism score	1.3	2.8	5.2	0.7	-2.3
Pulse rate, automated reading	1.3	4.1	5.9	-2.4	1.5
Alcohol drinker status: Never	1.3	1.6	2.1	-1.0	1.4
Pack years of smoking	1.3	1.9	2.5	-1.6	1.1
Lupus	1.2	1.8	2.5	1.0	-1.6
Hearing difficulty/problems: Yes	1.2	1.9	3.6	-1.9	0.4
Pack years adult smoking proportion	1.2	1.8	2.6	-1.6	1.0
Financial difficulties in last 2 years	1.2	1.6	2.3	-0.9	1.5
Father’s age at death	1.2	1.5	2.8	1.7	-0.6
Forced expiratory volume in 1-second (FEV1)	1.2	4.0	7.9	2.8	0.4
Standing height	1.2	12.2	18.5	-2.5	4.3
Medication: Aspirin	1.2	1.6	3.2	-0.3	1.8
Mood swings	1.2	2.2	3.9	0.7	-2.0
Medication: Aspirin	1.2	1.6	3.1	-0.1	1.8
Guilty feelings	1.2	1.7	2.9	-1.7	0.8
Ever depressed for a whole week	1.2	1.5	2.6	1.6	-0.6
Alcohol drinker status: Previous	1.2	1.4	2.7	-1.6	-0.3
Frequency of depressed mood in last 2 weeks	1.1	1.6	2.0	1.1	-1.4
Number of full brothers	1.1	1.4	2.8	0.1	1.7
Medication: Paracetamol	1.1	1.7	3.3	-1.8	0.3
Average weekly beer plus cider intake	1.1	1.6	2.5	0.9	-1.6
Alzheimer’s Disease (in father)	1.0	1.1	2.0	1.4	-0.4
Falls in the last year	1.0	1.3	1.7	-1.3	1.0
Medication: Cholesterol lowering	1.0	1.6	3.2	-1.8	0.2
Illnesses of mother	1.0	1.2	2.2	1.5	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	2.5	1.6	0.3
Number of children fathered	1.0	1.1	2.2	0.3	-1.5
Medication: Omeprazole	1.0	1.2	2.1	-0.4	-1.5
Handedness (chirality/laterality): Left-handed	1.0	1.2	1.6	-0.9	1.2
Eye problems/disorders: Cataract	1.0	1.1	1.4	1.2	0.9
Irritability	1.0	1.7	3.0	1.7	-0.7
Risk taking	1.0	1.5	2.7	0.6	1.6
Systolic blood pressure, automated reading	0.9	2.7	5.1	-2.3	0.5
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	2.0	-1.4	-0.2
Qualifications: CSEs or equivalent	0.9	1.1	2.2	-0.2	-1.5
Medication: Levothyroxine sodium	0.9	1.5	3.0	-0.3	1.7
Past tobacco smoking	0.9	1.7	3.0	-0.7	1.7
Medication: Simvastatin	0.9	1.3	2.6	-1.6	-0.1
Qualifications: A levels/AS levels or equivalent	0.9	1.9	2.9	1.7	1.0
Asthma	0.9	1.7	2.7	-0.9	-1.6
Migraine (self-reported)	0.9	1.1	1.7	0.7	-1.3
Commuting to job workplace: Car/motor vehicle	0.9	1.0	1.6	1.3	-0.6
Friendships satisfaction	0.9	1.1	2.3	1.5	0.0
Commuting to job workplace: Walk	0.9	0.9	1.5	1.2	0.6
Asthma (self-reported)	0.9	1.8	2.7	-1.0	-1.6
Heart disease (siblings)	0.9	1.1	2.2	-1.5	0.2
Neuroticism (2016)	0.8	1.1	1.6	0.8	-1.3
Ever had hysterectomy (womb removed)	0.8	0.9	1.5	-1.2	-0.6
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	1.7	1.3	-0.3
Fed-up feelings	0.8	1.4	1.8	-1.0	-1.3
Relative age voice broke	0.8	1.2	2.1	-0.6	-1.4
Sitting height	0.8	6.0	8.8	1.8	3.0
High blood pressure (mother)	0.8	1.1	2.3	-1.5	-0.1
Mouth/teeth dental problems	0.8	1.2	2.3	1.5	0.1
Diabetes (self-reported)	0.8	1.2	1.3	-1.1	1.1
Ever had bowel cancer screening	0.8	0.9	1.8	-1.3	0.1
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	2.5	0.4	-1.6
Eye problems/disorders: Glaucoma	0.8	1.0	1.9	1.4	0.3
Bipolar Disorder or Schizophrenia	0.7	1.8	3.5	1.9	0.0
Blood Platelet Count	0.7	8.3	15.9	4.0	-0.8
Medication for hormone replacement therapy	0.7	0.8	1.6	-0.1	1.3
Taking other prescription medications	0.7	1.0	1.1	-1.1	-1.0
Tinnitus: Yes, but not now, but have in the past	0.7	0.8	1.1	-1.1	-0.6
Multivitamins +/- minerals	0.7	0.9	1.8	-0.2	1.4
Number of live births	0.7	1.0	1.1	1.0	-1.0
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.9	1.2	1.1	0.7
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	1.7	-1.3	0.4
Lung cancer (father)	0.7	0.8	1.5	-1.2	0.4
Hair/balding pattern: Pattern 4	0.7	1.6	3.2	-1.8	0.2
Peak expiratory flow (PEF)	0.7	1.7	3.0	0.6	1.7
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.1	1.0	0.7
Age at first live birth	0.7	1.3	2.4	1.6	0.3
Average weekly red wine intake	0.7	1.0	1.3	1.1	0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	1.6	1.3	-0.1
Medication: Lisinopril	0.7	0.9	1.8	-1.4	-0.1
LDL Cholesterol	0.6	0.9	1.8	1.3	0.0
Townsend deprivation index at recruitment	0.6	0.8	1.5	-1.2	0.2
Age when periods started (menarche)	0.6	1.4	1.4	1.2	-1.2
Time employed in main current job	0.6	0.7	1.1	-1.1	0.5
Length of working week for main job	0.6	0.6	0.8	-0.9	0.7
Gout (self-reported)	0.6	0.8	1.1	1.1	-0.7
Heart disease (mother)	0.6	0.7	1.1	-0.5	-1.0
Number of full sisters	0.6	0.8	1.0	-0.8	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	2.4	0.1	1.6
Diabetes diagnosed by doctor	0.6	1.1	1.2	-1.1	0.9
Breast cancer (self-reported)	0.6	0.7	1.3	-0.4	-1.1
Hearing aid user	0.6	0.7	1.2	-1.1	0.5
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.3	1.2	-0.2
Irritable Bowel Disease (IBD)	0.5	1.2	2.4	-1.6	-0.3
Reaction Time	0.5	0.9	1.6	0.4	-1.3
Prostate Cancer	0.5	0.7	1.2	-1.1	-0.5
Schizophrenia (2014)	0.5	1.2	2.0	1.4	-0.6
Hypothyroidism (self reported)	0.5	1.1	1.6	1.2	0.8
Respiratory disease	0.5	1.2	1.9	-1.4	-0.7
Angina	0.5	0.7	1.2	-1.1	0.4
Diabetes (father)	0.5	0.6	0.8	0.6	0.9
Hair/balding pattern: Pattern 2	0.5	0.6	1.1	1.1	-0.4
Had other major operations	0.5	0.6	0.6	-0.8	-0.8
Forced vital capacity (FVC)	0.5	1.8	2.9	1.7	0.8
Fluid intelligence score	0.5	1.1	1.8	0.6	-1.3
Prospective memory result	0.5	0.6	1.2	-0.1	1.1
Glaucoma (self-reported)	0.5	0.5	1.1	1.0	-0.0
Medication: Amlodipine	0.5	0.7	0.7	-0.9	0.8
Angina (self-reported)	0.5	0.7	1.0	-1.0	0.5
Chest pain or discomfort	0.5	0.7	1.0	-1.0	0.6
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	0.8	-0.7	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	0.9	-0.6	-0.9
Illnesses of siblings: Diabetes	0.5	0.6	0.7	-0.9	0.7
Osteoporosis (self-reported)	0.5	0.6	1.0	-1.0	0.4
Major Depression (MDD)	0.4	0.5	1.0	1.0	0.0
Verbal and Numeric Reasoning (VNR)	0.4	0.9	1.8	0.2	-1.4
Breast Cancer	0.4	1.1	2.1	-1.4	0.3
Waist Hip Ratio (WHR)	0.4	1.6	3.2	-0.3	1.8
Systolic Blood Pressure	0.4	2.1	3.8	-1.9	0.7
Relative age of first facial hair	0.4	0.8	1.3	0.6	-1.1
Ever used hormone-replacement therapy (HRT)	0.4	0.5	0.9	-0.2	0.9
Vitamin and mineral supplements	0.4	0.6	1.0	0.4	-1.0
Stomach or abdominal pain in last month	0.4	0.5	0.8	-0.4	-0.9
Pulse rate	0.4	0.6	1.2	-0.2	1.1
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	1.4	0.4	1.2
Medication: Ventolin 100micrograms inhaler	0.4	0.6	1.1	0.1	-1.1
Illnesses of father: Heart disease	0.4	0.6	1.1	-0.1	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	0.8	-0.9	0.2
Back pain experienced in last month	0.4	0.6	0.7	-0.9	-0.7
Medication: Gliclazide	0.4	0.4	0.7	-0.4	0.9
Supplements: Fish oil (including cod liver oil)	0.4	0.5	0.7	0.6	0.9
Age started oral contraceptive pill	0.4	0.5	0.7	-0.5	-0.8
Commuting to job workplace: Cycle	0.4	0.5	0.6	0.8	-0.6
Fasting Glucose	0.3	0.3	0.6	0.8	0.0
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.7	0.8	0.0
Medication: Metformin	0.3	0.5	0.6	-0.8	0.6
Supplements: Glucosamine	0.3	0.4	0.6	-0.4	0.8
Medication: Atenolol	0.3	0.4	0.7	-0.3	0.8
Heart attack	0.3	0.3	0.6	0.8	0.4
Medication: Lansoprazole	0.3	0.3	0.7	-0.8	-0.1
Worry too long after embarrassment	0.3	0.5	0.5	0.7	-0.7
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.6	0.1	0.8
Had major operations	0.3	0.3	0.6	-0.3	-0.7
Loneliness, isolation	0.3	0.4	0.6	-0.4	0.8
Osteoarthritis (self-reported)	0.3	0.4	0.4	-0.7	-0.6
Miserableness	0.3	0.4	0.7	0.4	-0.9
Wears glasses or contact lenses	0.3	0.3	0.6	-0.8	0.2
Ever smoked	0.3	0.5	0.7	0.8	-0.5
Myopia	0.3	0.5	0.8	-0.4	0.9
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.6	0.8	0.6
Bipolar Disorder (2018)	0.2	0.3	0.5	0.7	0.0
Schizophrenia vs Biploar Disorder	0.2	0.3	0.5	-0.7	0.0
Body Mass Index (BMI) (2010)	0.2	0.3	0.6	-0.8	0.0
Mean Putamen Volume	0.2	0.2	0.3	-0.4	-0.5
HbA1C	0.2	0.2	0.4	-0.6	0.0
Tanning	0.2	2.8	5.1	0.7	-2.2
Average weekly spirits intake	0.2	0.3	0.5	-0.7	-0.2
Severe depression (siblings)	0.2	0.2	0.3	-0.5	-0.2
Alcohol usually taken with meals	0.2	0.3	0.5	0.7	0.4
Depression (self-reported)	0.2	0.3	0.5	-0.7	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.5	0.7	-0.4
Blood clot in the leg (DVT)	0.2	0.2	0.4	0.6	-0.1
Birth weight	0.2	0.5	0.9	-1.0	0.2
Medication: Allopurinol	0.2	0.2	0.4	0.6	0.0
Qualifications: nursing, teaching	0.2	0.3	0.4	0.6	0.4
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.2	0.4	0.5
Fractured/broken bones in last 5 years	0.2	0.2	0.4	-0.3	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.5	0.7	-0.1
Depression (Nagel 2018)	0.1	0.2	0.4	0.6	-0.1
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.6	0.8	-0.3
Crohns Disease (2017)	0.1	0.1	0.2	0.2	-0.5
Ovarian Cancer	0.1	0.2	0.3	0.5	-0.3
Smoking Status	0.1	0.2	0.5	0.1	-0.7
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.2	-0.2	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.2	0.2	0.4
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.1	-0.3	0.2
Hearing difficulty/problems with background noise	0.1	0.1	0.2	-0.5	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.2	-0.2	-0.4
Hair/balding pattern: Pattern 3	0.1	0.2	0.3	0.5	-0.3
Noisy workplace	0.1	0.2	0.3	-0.1	-0.6
Breastfed as a baby	0.1	0.1	0.1	0.2	0.3
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.2	0.5	0.3
Exposure to tobacco smoke outside home	0.1	0.1	0.2	-0.5	0.1
Shortness of breath walking on level ground	0.1	0.1	0.2	-0.4	-0.3
Medication: Ibuprofen	0.1	0.1	0.2	-0.4	0.0
Mean time to correctly identify matches	0.1	0.1	0.1	0.3	-0.4
Mineral and other dietary supplements	0.1	0.1	0.2	-0.2	-0.4
Ever taken oral contraceptive pill	0.1	0.1	0.2	0.2	0.4
Financial situation satisfaction	0.1	0.2	0.3	-0.2	0.6
Commuting to job workplace: Public transport	0.1	0.2	0.3	-0.2	0.5
Supplements: Calcium	0.1	0.1	0.2	-0.1	0.5
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.0	0.0	0.0	0.2	0.0
HDL Cholesterol	0.0	0.0	0.0	0.1	0.0
Hair Pigment	0.0	1.0	1.1	0.9	-1.0
Ever unenthusiastic/disinterested for a whole week	0.0	0.0	0.0	-0.2	0.1
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.0	0.1	-0.1
Qualifications: O levels/GCSEs or equivalent	0.0	0.1	0.1	0.2	0.2
Medication: Seretide 50 evohaler	0.0	0.0	0.1	-0.1	0.3
Leg pain on walking	0.0	0.0	0.1	0.2	0.1
Illnesses of father: None of the above (group 1)	0.0	0.1	0.1	0.1	0.3

Hub : Genes

ZNF48

Models

Trait associations