Best TWAS P=2.52e-12 · Best GWAS P=4.71e-12 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | LIME1 | 0.04 | 0.00 | bslmm | 439 | 0.01 | 3.3e-02 | -3.4 | 5.3 | 9.5e-08 | -0.17 | 0.28 | 0.04 | TRUE |
2 | CommonMind | Brain Pre-frontal Cortex | TPD52L2 | 0.13 | 0.07 | bslmm | 418 | 0.08 | 4.5e-10 | -4.9 | 5.8 | 7.3e-09 | -0.36 | 0.72 | 0.27 | FALSE |
3 | CommonMind | Brain Pre-frontal Cortex | ZBTB46 | 0.11 | 0.08 | lasso | 3 | 0.07 | 1.2e-08 | -6.9 | -7.0 | 2.5e-12 | 1.00 | 0.00 | 1.00 | TRUE |
4 | GTEx | Adrenal Gland | OPRL1 | 0.48 | 0.29 | enet | 21 | 0.22 | 1.5e-08 | -5.9 | -5.5 | 4.9e-08 | 0.31 | 0.50 | 0.50 | FALSE |
5 | GTEx | Adrenal Gland | RGS19 | 0.32 | 0.20 | lasso | 8 | 0.21 | 5.8e-08 | -5.9 | -6.1 | 8.5e-10 | 0.26 | 0.28 | 0.41 | FALSE |
6 | GTEx | Artery Aorta | TPD52L2 | 0.16 | 0.07 | enet | 15 | 0.16 | 4.4e-09 | 1.8 | -5.5 | 2.9e-08 | 0.20 | 0.70 | 0.04 | TRUE |
7 | GTEx | Artery Aorta | OPRL1 | 0.27 | 0.19 | lasso | 4 | 0.17 | 1.4e-09 | -5.9 | -6.8 | 8.9e-12 | 0.35 | 0.38 | 0.62 | FALSE |
8 | GTEx | Artery Aorta | TCEA2 | 0.09 | 0.04 | lasso | 3 | 0.03 | 1.3e-02 | -5.9 | 6.3 | 2.3e-10 | -0.23 | 0.31 | 0.28 | FALSE |
9 | GTEx | Artery Tibial | OPRL1 | 0.10 | 0.10 | lasso | 2 | 0.06 | 1.1e-05 | -5.9 | -6.0 | 2.1e-09 | 0.26 | 0.40 | 0.56 | FALSE |
10 | GTEx | Artery Tibial | RGS19 | 0.12 | 0.07 | lasso | 2 | 0.07 | 2.8e-06 | 5.5 | -5.3 | 9.5e-08 | 0.25 | 0.75 | 0.20 | FALSE |
11 | GTEx | Brain Cerebellar Hemisphere | OPRL1 | 0.27 | 0.14 | lasso | 7 | 0.17 | 4.4e-05 | -5.9 | -5.2 | 1.5e-07 | 0.27 | 0.09 | 0.10 | FALSE |
12 | GTEx | Brain Cerebellum | RGS19 | 0.28 | 0.22 | lasso | 4 | 0.18 | 7.2e-06 | -5.9 | -5.4 | 5.7e-08 | 0.27 | 0.20 | 0.24 | FALSE |
13 | GTEx | Breast Mammary Tissue | GMEB2 | 0.18 | 0.02 | lasso | 5 | 0.06 | 3.0e-04 | -3.4 | -5.3 | 1.1e-07 | 0.11 | 0.16 | 0.04 | FALSE |
14 | GTEx | Cells Transformed fibroblasts | RGS19 | 0.37 | 0.28 | lasso | 8 | 0.29 | 3.2e-22 | 5.5 | -5.7 | 1.3e-08 | 0.26 | 0.84 | 0.16 | FALSE |
15 | GTEx | Colon Sigmoid | RGS19 | 0.27 | 0.07 | enet | 33 | 0.09 | 3.8e-04 | -4.2 | -5.9 | 3.4e-09 | 0.38 | 0.43 | 0.20 | FALSE |
16 | GTEx | Esophagus Mucosa | RGS19 | 0.43 | 0.28 | enet | 17 | 0.34 | 7.9e-24 | -5.9 | -6.2 | 4.4e-10 | 0.30 | 0.50 | 0.50 | FALSE |
17 | GTEx | Esophagus Muscularis | OPRL1 | 0.17 | 0.14 | lasso | 1 | 0.13 | 4.7e-08 | -5.9 | -5.9 | 3.4e-09 | 0.25 | 0.38 | 0.60 | FALSE |
18 | GTEx | Esophagus Muscularis | RGS19 | 0.22 | 0.10 | lasso | 4 | 0.10 | 1.6e-06 | -5.9 | -5.5 | 3.0e-08 | 0.26 | 0.43 | 0.54 | FALSE |
19 | GTEx | Muscle Skeletal | RGS19 | 0.26 | 0.16 | lasso | 4 | 0.16 | 5.1e-15 | 5.5 | -5.3 | 1.0e-07 | 0.27 | 0.89 | 0.11 | FALSE |
20 | GTEx | Nerve Tibial | OPRL1 | 0.20 | 0.15 | lasso | 3 | 0.14 | 3.3e-10 | -5.9 | -6.3 | 3.6e-10 | 0.24 | 0.38 | 0.62 | FALSE |
21 | GTEx | Pancreas | OPRL1 | 0.39 | 0.27 | lasso | 5 | 0.32 | 6.9e-14 | -5.9 | -5.7 | 1.1e-08 | 0.27 | 0.48 | 0.52 | FALSE |
22 | GTEx | Skin Not Sun Exposed Suprapubic | RGS19 | 0.51 | 0.28 | enet | 28 | 0.32 | 4.3e-18 | -5.9 | -5.8 | 5.9e-09 | 0.23 | 0.41 | 0.59 | FALSE |
23 | GTEx | Skin Sun Exposed Lower leg | OPRL1 | 0.14 | 0.10 | lasso | 6 | 0.11 | 4.4e-09 | 5.5 | -5.8 | 6.3e-09 | 0.27 | 0.63 | 0.37 | FALSE |
24 | GTEx | Skin Sun Exposed Lower leg | RGS19 | 0.42 | 0.26 | lasso | 6 | 0.33 | 4.6e-28 | -5.9 | -6.0 | 2.5e-09 | 0.28 | 0.53 | 0.47 | FALSE |
25 | GTEx | Stomach | OPRL1 | 0.36 | 0.23 | enet | 16 | 0.19 | 1.3e-09 | -5.9 | -6.6 | 5.0e-11 | 0.28 | 0.39 | 0.61 | FALSE |
26 | GTEx | Stomach | RGS19 | 0.18 | 0.25 | lasso | 2 | 0.25 | 2.2e-12 | -5.9 | -6.0 | 2.5e-09 | 0.25 | 0.38 | 0.62 | FALSE |
27 | GTEx | Thyroid | RGS19 | 0.23 | 0.14 | enet | 11 | 0.19 | 3.3e-14 | 5.5 | -5.8 | 6.9e-09 | 0.35 | 0.70 | 0.30 | FALSE |
28 | GTEx | Vagina | RGS19 | 0.39 | 0.08 | lasso | 8 | 0.03 | 7.5e-02 | 5.5 | -6.4 | 2.1e-10 | 0.27 | 0.06 | 0.08 | FALSE |
29 | GTEx | Whole Blood | OPRL1 | 0.09 | 0.06 | enet | 8 | 0.07 | 4.3e-07 | 5.6 | 5.6 | 2.7e-08 | -0.26 | 0.70 | 0.28 | FALSE |
30 | ROSMAP | Brain Pre-frontal Cortex | ZBTB46 | 0.11 | 0.07 | lasso | 1 | 0.06 | 5.2e-08 | -6.9 | -6.9 | 4.7e-12 | 1.00 | 0.00 | 1.00 | FALSE |
31 | YFS | Blood | OPRL1 | 0.07 | 0.07 | lasso | 5 | 0.09 | 5.0e-27 | -5.9 | 5.2 | 1.5e-07 | -0.26 | 0.49 | 0.51 | FALSE |
32 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RGS19 | 0.03 | 0.02 | blup | 48 | 0.02 | 6.9e-06 | 5.2 | -5.5 | 3.5e-08 | 0.14 | 0.02 | 0.97 | FALSE |
33 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | RGS19 | 0.06 | 0.06 | blup | 47 | 0.05 | 1.4e-06 | -5.9 | -5.2 | 1.6e-07 | 0.22 | 0.00 | 1.00 | FALSE |
34 | The Cancer Genome Atlas | Brain Lower Grade Glioma | OPRL1 | 0.03 | 0.02 | lasso | 1 | 0.01 | 3.5e-02 | -5.9 | -5.9 | 3.4e-09 | 0.25 | 0.00 | 0.98 | FALSE |
35 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | RGS19 | 0.11 | 0.00 | blup | 48 | 0.03 | 1.7e-02 | 5.2 | -5.9 | 3.2e-09 | 0.19 | 0.02 | 0.55 | TRUE |
36 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RGS19 | 0.07 | 0.05 | blup | 48 | 0.07 | 1.1e-07 | -4.3 | -6.1 | 9.6e-10 | 0.28 | 0.05 | 0.95 | FALSE |
37 | The Cancer Genome Atlas | Thyroid Carcinoma | UCKL1AS | 0.05 | 0.02 | blup | 41 | 0.03 | 4.6e-04 | 4.3 | -5.6 | 1.6e-08 | 0.16 | 0.05 | 0.44 | FALSE |