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chr17:6,202,301-8,484,683

Best TWAS P=6.74e-12 · Best GWAS P=6.74e-12 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
12	The Cancer Genome Atlas	Colon Adenocarcinoma	CYB5D1	0.14	0.12	lasso	1	0.10	1.7e-06	6.9	-6.9	6.7e-12	-1.00	0.00	1.00	TRUE
5	METSIM	Adipose	SENP3	0.06	0.03	lasso	3	0.02	4.9e-04	6.1	-6.8	8.2e-12	-0.11	0.23	0.54	TRUE
1	CommonMind	Brain Pre-frontal Cortex	SLC2A4	0.08	0.06	lasso	2	0.08	1.2e-09	-4.0	5.3	1.3e-07	0.04	0.93	0.02	TRUE
6	NTR	Blood	ALOX12	0.02	0.01	lasso	3	0.01	1.5e-04	4.2	5.1	3.0e-07	0.01	0.04	0.35	TRUE
14	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TNFSF12	0.04	0.01	enet	9	0.01	4.3e-02	6.1	-6.8	1.2e-11	-0.08	0.00	0.92	FALSE
16	The Cancer Genome Atlas	Prostate Adenocarcinoma	SHBG	0.04	0.01	blup	60	0.03	5.4e-04	5.0	6.7	2.0e-11	0.10	0.01	0.60	FALSE
3	GTEx	Colon Transverse	LSMD1	0.28	0.12	lasso	5	0.19	3.3e-09	6.9	6.5	6.5e-11	0.89	0.00	0.99	FALSE
13	The Cancer Genome Atlas	Colon Adenocarcinoma	TNFSF12-TNFSF13	0.07	0.05	lasso	3	0.02	1.9e-02	6.1	6.2	6.7e-10	0.11	0.00	0.95	FALSE
8	ROSMAP	Brain Pre-frontal Cortex	KDM6B	0.07	0.05	lasso	4	0.04	2.7e-06	6.8	-6.2	7.0e-10	-0.95	0.00	1.00	FALSE
7	NTR	Blood	TNFSF12	0.06	0.07	bslmm	462	0.07	9.4e-23	5.9	6.1	1.3e-09	0.11	0.70	0.30	FALSE
17	The Cancer Genome Atlas	Prostate Adenocarcinoma	TNFSF12-TNFSF13	0.03	0.00	lasso	4	0.01	2.9e-02	5.6	5.9	3.3e-09	0.13	0.01	0.69	FALSE
2	GTEx	Cells Transformed fibroblasts	TNFSF12	0.25	0.22	lasso	8	0.20	7.4e-15	5.6	5.7	1.1e-08	0.14	0.85	0.15	FALSE
15	The Cancer Genome Atlas	Brain Lower Grade Glioma	SLC2A4	0.09	0.04	lasso	4	0.06	7.2e-08	-4.9	5.7	1.6e-08	0.05	0.00	0.99	FALSE
4	GTEx	Heart Left Ventricle	CHRNB1	0.16	0.03	lasso	4	0.05	9.6e-04	3.8	-5.6	1.9e-08	-0.36	0.04	0.71	FALSE
9	ROSMAP	Brain Pre-frontal Cortex	SENP3	0.07	0.06	lasso	4	0.05	1.5e-07	5.4	-5.5	3.5e-08	-0.04	0.95	0.05	FALSE
18	The Cancer Genome Atlas	Thyroid Carcinoma	SHBG	0.04	0.00	blup	59	0.02	4.4e-03	6.0	5.5	3.6e-08	0.10	0.01	0.83	FALSE
11	YFS	Blood	CYB5D1	0.28	0.19	bslmm	488	0.24	5.9e-79	4.5	-5.3	1.3e-07	-0.73	1.00	0.00	FALSE
10	ROSMAP	Brain Pre-frontal Cortex	TNFSF12	0.10	0.04	lasso	6	0.06	9.2e-08	5.6	5.3	1.4e-07	0.14	0.76	0.24	FALSE