Best TWAS P=6.74e-12 · Best GWAS P=6.74e-12 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | SLC2A4 | 0.08 | 0.06 | lasso | 2 | 0.08 | 1.2e-09 | -4.0 | 5.3 | 1.3e-07 | 0.04 | 0.93 | 0.02 | TRUE |
| 2 | GTEx | Cells Transformed fibroblasts | TNFSF12 | 0.25 | 0.22 | lasso | 8 | 0.20 | 7.4e-15 | 5.6 | 5.7 | 1.1e-08 | 0.14 | 0.85 | 0.15 | FALSE |
| 3 | GTEx | Colon Transverse | LSMD1 | 0.28 | 0.12 | lasso | 5 | 0.19 | 3.3e-09 | 6.9 | 6.5 | 6.5e-11 | 0.89 | 0.00 | 0.99 | FALSE |
| 4 | GTEx | Heart Left Ventricle | CHRNB1 | 0.16 | 0.03 | lasso | 4 | 0.05 | 9.6e-04 | 3.8 | -5.6 | 1.9e-08 | -0.36 | 0.04 | 0.71 | FALSE |
| 5 | METSIM | Adipose | SENP3 | 0.06 | 0.03 | lasso | 3 | 0.02 | 4.9e-04 | 6.1 | -6.8 | 8.2e-12 | -0.11 | 0.23 | 0.54 | TRUE |
| 6 | NTR | Blood | ALOX12 | 0.02 | 0.01 | lasso | 3 | 0.01 | 1.5e-04 | 4.2 | 5.1 | 3.0e-07 | 0.01 | 0.04 | 0.35 | TRUE |
| 7 | NTR | Blood | TNFSF12 | 0.06 | 0.07 | bslmm | 462 | 0.07 | 9.4e-23 | 5.9 | 6.1 | 1.3e-09 | 0.11 | 0.70 | 0.30 | FALSE |
| 8 | ROSMAP | Brain Pre-frontal Cortex | KDM6B | 0.07 | 0.05 | lasso | 4 | 0.04 | 2.7e-06 | 6.8 | -6.2 | 7.0e-10 | -0.95 | 0.00 | 1.00 | FALSE |
| 9 | ROSMAP | Brain Pre-frontal Cortex | SENP3 | 0.07 | 0.06 | lasso | 4 | 0.05 | 1.5e-07 | 5.4 | -5.5 | 3.5e-08 | -0.04 | 0.95 | 0.05 | FALSE |
| 10 | ROSMAP | Brain Pre-frontal Cortex | TNFSF12 | 0.10 | 0.04 | lasso | 6 | 0.06 | 9.2e-08 | 5.6 | 5.3 | 1.4e-07 | 0.14 | 0.76 | 0.24 | FALSE |
| 11 | YFS | Blood | CYB5D1 | 0.28 | 0.19 | bslmm | 488 | 0.24 | 5.9e-79 | 4.5 | -5.3 | 1.3e-07 | -0.73 | 1.00 | 0.00 | FALSE |
| 12 | The Cancer Genome Atlas | Colon Adenocarcinoma | CYB5D1 | 0.14 | 0.12 | lasso | 1 | 0.10 | 1.7e-06 | 6.9 | -6.9 | 6.7e-12 | -1.00 | 0.00 | 1.00 | TRUE |
| 13 | The Cancer Genome Atlas | Colon Adenocarcinoma | TNFSF12-TNFSF13 | 0.07 | 0.05 | lasso | 3 | 0.02 | 1.9e-02 | 6.1 | 6.2 | 6.7e-10 | 0.11 | 0.00 | 0.95 | FALSE |
| 14 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TNFSF12 | 0.04 | 0.01 | enet | 9 | 0.01 | 4.3e-02 | 6.1 | -6.8 | 1.2e-11 | -0.08 | 0.00 | 0.92 | FALSE |
| 15 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SLC2A4 | 0.09 | 0.04 | lasso | 4 | 0.06 | 7.2e-08 | -4.9 | 5.7 | 1.6e-08 | 0.05 | 0.00 | 0.99 | FALSE |
| 16 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SHBG | 0.04 | 0.01 | blup | 60 | 0.03 | 5.4e-04 | 5.0 | 6.7 | 2.0e-11 | 0.10 | 0.01 | 0.60 | FALSE |
| 17 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TNFSF12-TNFSF13 | 0.03 | 0.00 | lasso | 4 | 0.01 | 2.9e-02 | 5.6 | 5.9 | 3.3e-09 | 0.13 | 0.01 | 0.69 | FALSE |
| 18 | The Cancer Genome Atlas | Thyroid Carcinoma | SHBG | 0.04 | 0.00 | blup | 59 | 0.02 | 4.4e-03 | 6.0 | 5.5 | 3.6e-08 | 0.10 | 0.01 | 0.83 | FALSE |