Hub : Genes

ALOX12

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Breast Mammary Tissue	0.2320	0.0680	1.5e-03	0.121	NA	0.129	NA	0.139	9.2e-07	NA	4.0e-07	NA	1.2e-07
2	GTEx	Breast Mammary Tissue (Female)	0.0481	0.1096	3.7e-01	-0.009	NA	0.004	NA	-0.010	8.1e-01	NA	2.4e-01	NA	9.7e-01
3	GTEx	Colon Transverse	0.1880	0.0620	3.4e-03	0.159	NA	0.154	NA	0.161	5.3e-08	NA	8.3e-08	NA	4.2e-08
4	NTR	Blood	0.0238	0.0099	2.7e-03	0.008	0.005	0.006	0.005	0.011	1.1e-03	9.7e-03	4.3e-03	9.0e-03	1.5e-04
5	YFS	Blood	0.0534	0.0147	6.6e-06	0.022	0.023	0.036	0.042	0.041	5.2e-08	3.7e-08	5.1e-12	1.5e-13	2.0e-13
6	TCGA	Bladder Urothelial Carcinoma	0.0990	0.0360	1.1e-07	0.123	0.098	0.109	NA	0.113	1.4e-10	1.2e-08	1.8e-09	NA	8.3e-10
7	TCGA	Cervical Squamous Cell Carcinoma	0.1560	0.0690	1.3e-03	0.080	0.043	0.037	NA	0.058	9.6e-05	3.3e-03	6.6e-03	NA	7.8e-04
8	TCGA	Head and Neck Squamous Cell Carcinoma	0.1014	0.0358	2.2e-09	0.102	0.086	0.100	NA	0.106	1.6e-11	7.1e-10	2.4e-11	NA	6.8e-12
9	TCGA	Lung Squamous Cell Carcinoma	0.0451	0.0185	1.4e-05	0.060	0.045	0.057	NA	0.055	2.3e-07	7.7e-06	4.7e-07	NA	7.0e-07
10	TCGA	Ovarian Serous Cystadenocarcinoma	0.0670	0.0340	1.3e-03	0.053	0.014	0.022	NA	0.048	1.7e-04	3.7e-02	1.2e-02	NA	3.6e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	1.4	2.2	4.4	1.5	1.9	2.1	0.2	-0.0	-1.4	-1.4	-1.3	-1.3	-2.1
Bipolar Disorder or Schizophrenia	1.0	2.3	6.8	1.9	2.6	1.7	0.6	-1.8	-1.0	-0.9	-1.0	-1.2	-1.4
Depressed Affect (Nagel 2018)	0.4	0.8	2.5	-0.7	-1.2	-0.0	1.6	1.4	0.6	0.4	0.7	0.8	0.1
Depression (Nagel 2018)	0.1	0.2	0.7	-0.4	-0.1	0.1	-0.2	0.9	0.5	0.4	0.5	0.6	-0.1
Intelligence (Savage-Jansen 2018)	0.5	1.5	2.5	1.6	1.0	1.0	-0.4	0.8	-1.5	-1.5	-1.4	-1.5	-0.9
Neuroticism (Nagel 2018)	0.5	1.1	5.1	-0.5	-2.3	0.2	1.3	1.5	0.6	0.3	0.5	0.9	-0.1
Schizophrenia (2018)	0.5	1.1	5.3	1.2	1.9	0.4	0.7	-2.3	-0.2	-0.1	-0.2	-0.4	-0.2
Schizophrenia vs Biploar Disorder	2.5	3.2	5.3	-1.6	-0.1	-2.1	1.3	0.3	2.2	2.3	1.8	2.1	2.3
Worry (Nagel 2018)	0.2	0.5	2.0	0.1	-1.0	-0.1	1.4	1.1	0.3	0.2	0.3	0.7	0.2
Alzheimer’s Disease (in mother)	0.6	0.7	1.5	1.2	-0.2	0.6	0.7	-0.5	-1.0	-0.9	-1.0	-1.2	-0.4
Alzheimer’s Disease (in father)	0.2	0.2	1.4	-0.3	-0.3	0.1	-0.2	-1.2	0.2	0.2	0.3	-0.1	0.2
Alzheimer’s Disease (including proxy)	0.6	0.9	2.1	1.2	-0.3	1.0	0.6	-1.5	-0.9	-0.7	-0.8	-1.3	-0.7
Crohns Disease (2017)	0.4	0.9	6.8	-0.5	-0.5	0.5	2.6	0.1	0.6	0.5	0.5	0.6	-0.1
Irritable Bowel Disease (IBD)	0.2	0.5	2.0	0.3	0.2	1.3	1.4	0.0	-0.4	-0.4	-0.4	-0.1	-1.1
Ulcerative Colitis (UC)	0.5	0.9	2.2	0.8	1.0	1.3	-0.1	-0.2	-1.1	-0.9	-1.0	-0.8	-1.5
Major Depression (MDD)	0.2	0.3	1.0	0.0	0.9	-0.1	1.0	-0.7	0.2	0.1	0.3	0.2	0.3
Reaction Time	0.1	0.2	1.2	0.4	-1.1	0.0	-0.4	-0.5	-0.2	-0.2	-0.2	-0.1	0.1
Verbal and Numeric Reasoning (VNR)	0.3	0.7	3.8	0.7	0.9	0.3	-0.0	1.9	-0.7	-0.7	-0.8	-0.3	-0.5
Breast Cancer	0.5	1.3	6.9	0.4	-0.6	-0.6	2.6	1.9	-0.7	-0.7	-0.8	-0.4	0.4
Ovarian Cancer	0.5	0.7	2.9	-0.8	-0.7	-1.4	0.2	0.9	0.1	0.0	0.4	0.0	1.7
Prostate Cancer	0.7	1.0	2.4	-1.1	0.3	-0.7	-1.1	1.6	0.8	0.7	0.8	1.4	0.5
Age at First Birth	0.1	0.1	0.4	-0.2	0.1	-0.3	-0.6	-0.4	0.1	0.5	0.4	0.1	0.5
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	1.0	1.4	3.2	-0.8	0.1	-1.6	1.8	1.0	1.0	1.1	1.0	0.8	1.8
Coronary Artery Disease (CAD)	0.0	0.0	0.3	0.0	0.0	0.0	0.5	-0.1	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.9	1.4	3.3	0.7	0.1	1.5	1.8	-0.1	-1.2	-1.2	-1.3	-1.2	-1.2
Mean Putamen Volume	0.8	0.9	4.1	-1.1	-0.5	-0.3	0.8	-2.0	0.7	0.9	0.9	0.6	0.5
Fasting Glucose	1.1	1.3	2.9	-1.4	-0.4	-1.2	-0.1	1.7	1.1	1.2	1.0	1.2	1.2
HbA1C	0.3	0.3	2.3	-0.1	0.4	-0.2	-0.3	1.5	-0.3	0.2	-0.2	0.3	0.1
HDL Cholesterol	0.2	0.4	2.0	-0.0	1.0	-0.4	-0.8	1.4	0.2	-0.2	0.0	0.2	0.5
LDL Cholesterol	0.1	0.2	0.7	0.0	-0.2	-0.7	-0.8	0.4	0.5	0.4	0.3	0.3	0.6
Lupus	0.3	0.5	3.1	-0.1	0.4	-0.4	-0.3	1.8	-0.6	-0.6	-0.7	-0.5	-0.0
Neuroticism (2016)	0.2	0.3	1.4	0.4	-0.0	0.9	0.0	0.0	-0.6	-0.5	-0.5	-0.3	-1.2
Primary Biliary Cirrhosis	0.9	1.3	3.7	0.5	0.0	1.8	-1.0	-1.9	-0.6	-0.6	-0.6	-0.7	-1.7
Rheumatoid Arthritis	0.1	0.2	0.7	0.8	0.1	-0.6	0.2	0.3	-0.2	-0.1	-0.2	-0.1	0.6
Schizophrenia (2014)	0.7	1.5	3.6	1.2	1.6	1.4	1.6	-1.9	-0.6	-0.6	-0.7	-0.6	-1.0
Triglycerides	1.6	2.7	4.1	-1.9	-0.6	-1.7	-1.1	0.2	1.9	2.0	2.0	2.0	1.6
Type 2 Diabetes (T2D) (2012)	0.2	0.2	1.3	0.1	-0.3	0.2	-0.2	-1.1	0.4	0.0	0.3	0.2	-0.3
Ulcerative Colitis	0.7	1.0	2.5	0.8	0.2	1.4	-0.4	-0.0	-1.2	-1.2	-1.1	-0.9	-1.6
Blood Eosinophil Count	0.0	0.2	0.6	0.5	-0.8	0.4	0.7	-0.4	-0.3	-0.3	-0.3	-0.2	-0.2
Blood Platelet Count	0.3	3.0	6.2	0.8	-2.4	2.5	-0.8	-2.0	-1.3	-1.3	-1.5	-1.0	-2.4
Blood Red Count	0.2	2.0	3.3	-1.8	-0.7	-0.9	0.4	-1.8	1.7	1.6	1.8	1.5	1.0
Blood White Count	0.4	2.9	10.8	0.8	-3.3	1.8	2.8	0.2	-0.9	-1.1	-1.0	-0.3	-1.7
Heel T-Score	0.1	1.0	3.7	-1.6	-1.5	-0.2	1.0	-1.9	0.2	0.3	0.5	0.0	0.2
BMI	0.5	3.0	6.6	-2.6	-0.2	-1.7	1.4	-0.0	1.9	1.9	2.0	2.0	1.7
Height	0.0	0.7	2.4	-1.6	-0.2	1.1	-0.1	-1.3	0.5	0.5	0.4	-0.3	-0.7
Waist Hip Ratio (WHR)	0.3	1.1	2.1	-1.5	-1.2	-0.4	1.0	-0.7	1.2	1.3	1.2	0.9	0.7
Systolic Blood Pressure	0.7	3.7	25.1	0.0	2.9	-0.3	5.0	-0.1	0.7	0.7	0.8	0.8	0.7
Smoking Status	0.2	0.5	2.4	0.6	-1.1	-0.3	0.5	1.6	-0.3	-0.4	-0.4	-0.1	0.2
Allergy or Eczema	0.6	1.5	6.1	0.1	1.7	1.0	-2.5	-1.6	-0.4	-0.5	-0.5	-0.8	-0.9
Cardiovascular Disease	0.4	1.4	12.7	-0.4	-0.1	-0.3	3.6	-0.6	0.5	0.4	0.5	0.5	0.5
Hypothyroidism (self reported)	0.2	0.5	1.0	-0.9	1.0	-0.6	-0.6	0.9	0.5	0.4	0.3	0.4	0.7
Respiratory disease	0.1	0.3	2.4	0.2	0.3	-0.0	-0.6	-1.5	0.0	0.1	0.1	-0.4	-0.1
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.0	-0.7	-0.8	-0.4	1.0	-0.3	0.7	0.7	0.6	0.5	0.5
Lung FEV1/FVC ratio	0.1	0.5	1.9	-1.2	-0.5	-0.5	0.0	-1.4	0.5	0.5	0.3	0.5	0.3
Lung FVC	0.1	0.6	4.5	0.1	0.3	-0.3	-2.1	1.2	0.1	0.1	-0.1	0.5	0.1
Neuroticism	0.5	1.2	2.8	-1.1	-1.5	0.0	1.7	1.6	0.9	0.8	0.9	1.1	0.2
Chronotype (morning person)	0.2	0.4	1.3	0.6	-0.2	0.6	-0.2	-1.2	-0.7	-0.7	-0.6	-0.5	-0.6
Hair Pigment	0.0	0.1	0.6	0.4	0.2	-0.2	-0.8	0.3	-0.2	0.3	0.1	0.1	0.2
Tanning	0.2	2.3	5.3	2.3	-0.2	1.6	0.0	-0.3	-1.8	-1.7	-1.7	-1.9	-1.5
Hand grip strength (left)	0.5	1.4	11.3	-0.9	-0.8	-0.6	-3.4	0.9	0.1	0.2	-0.0	-0.2	0.4
Number of treatments/medications taken	0.4	0.7	4.5	-0.3	-0.4	-0.3	2.1	-0.8	0.4	0.5	0.7	0.5	0.3
Average weekly spirits intake	0.4	0.5	1.9	-0.1	0.1	-0.8	-1.4	-1.3	0.3	0.3	0.3	0.2	0.6
Sensitivity / hurt feelings	0.2	0.3	0.9	-0.9	-0.2	0.2	0.1	0.4	0.7	0.7	0.7	0.9	-0.1
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.6	-0.4	-0.2	0.8	-0.1	0.2	0.5	0.5	0.5	0.7	-0.7
Hearing difficulty/problems: Yes	1.4	2.1	3.6	1.7	0.5	1.5	-1.2	-1.4	-1.5	-1.5	-1.4	-1.9	-1.4
Relative age of first facial hair	2.4	4.9	7.8	-2.4	-0.7	-2.8	-2.4	2.1	2.1	2.0	2.2	2.2	2.6
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.1	0.6	-0.7	0.5	1.1	-0.7	-0.9	-0.9	-0.8	-0.8	-0.7
Ever used hormone-replacement therapy (HRT)	0.2	0.3	1.6	0.1	-0.2	-0.0	0.8	-1.3	-0.0	0.0	0.0	-0.6	0.1
Ever had hysterectomy (womb removed)	0.4	0.4	3.7	-0.5	-0.5	-0.3	1.9	0.2	0.1	0.1	0.1	0.0	-0.0
Systolic blood pressure, automated reading	0.6	1.8	10.6	0.9	2.3	0.6	3.3	-0.1	-0.3	-0.3	-0.2	-0.2	-0.4
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.0	0.6	-0.1	0.6	0.2	1.0	-0.8	-0.8	-0.7	-0.7	-0.5
Angina	0.7	0.9	3.4	0.6	-1.0	1.1	1.9	-0.5	-0.6	-0.6	-0.5	-0.5	-1.1
Medication for hormone replacement therapy	0.8	0.9	1.8	-0.7	-0.4	-0.6	-0.6	-0.8	1.3	1.3	1.3	1.3	0.5
Vitamin and mineral supplements	0.3	0.4	0.7	-0.3	-0.6	0.9	0.2	-0.8	-0.5	-0.7	-0.8	-0.5	-0.8
Supplements: Zinc	2.9	3.2	6.3	-2.0	0.5	-2.5	-0.7	-0.7	1.9	2.2	2.0	1.6	2.4
Medication: Co-codamol	0.6	0.7	6.1	0.5	2.5	0.1	0.4	0.3	0.1	0.0	0.1	0.5	0.0
Medication: Metformin	0.1	0.2	0.8	-0.6	-0.0	-0.2	0.5	-0.9	0.1	0.1	0.4	-0.1	0.0
Diabetes (father)	0.4	0.5	3.1	0.4	0.4	0.1	1.0	1.8	-0.4	-0.5	-0.5	-0.0	-0.4
Diabetes (mother)	0.2	0.2	1.2	-0.2	-0.5	0.2	0.3	-1.1	-0.3	-0.2	-0.3	-0.4	0.0
Severe depression (siblings)	0.5	0.6	2.0	-0.4	1.4	0.3	-0.6	-0.6	0.8	0.8	0.7	0.8	-0.4
Pack years adult smoking proportion	1.2	1.8	3.8	-1.0	-1.8	-0.7	0.1	1.6	1.6	1.4	1.4	1.9	0.8
Impedance of leg (right)	0.3	1.2	2.9	-0.9	0.3	-0.1	-0.7	1.7	1.4	1.3	1.2	1.6	0.3
Leg fat-free mass (left)	0.9	4.5	7.0	-2.6	-2.1	-2.3	1.2	-0.9	2.4	2.3	2.4	2.0	2.4
Trunk fat percentage	1.3	5.0	7.2	-2.5	-0.4	-2.7	1.6	-0.0	2.6	2.6	2.6	2.5	2.7
Hand grip strength (right)	0.5	1.3	10.9	-0.1	-1.2	-0.4	-3.3	0.1	-0.1	-0.0	-0.2	-0.4	0.3
Townsend deprivation index at recruitment	0.2	0.3	1.7	-0.1	0.2	0.0	-0.6	1.3	0.5	0.4	0.1	1.0	-0.3
Current tobacco smoking	0.2	0.3	2.5	0.3	0.5	-0.2	-0.3	1.6	0.2	0.1	-0.0	0.7	-0.0
Average weekly fortified wine intake	0.2	0.2	1.1	0.7	0.2	-0.0	-1.0	0.3	-0.1	-0.0	-0.1	-0.0	-0.0
Maternal smoking around birth	0.6	0.8	3.0	0.6	-0.2	1.7	0.5	-0.8	-0.6	-0.6	-0.7	-0.6	-1.6
Fed-up feelings	0.2	0.3	1.3	-0.4	0.3	-0.1	1.2	1.0	0.2	0.1	0.2	0.4	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	0.8	-0.6	0.9	0.4	-0.8	0.4	0.8	0.8	0.7	0.9	-0.4
Relative age voice broke	1.2	1.9	4.2	-1.5	-1.1	-2.1	-1.1	1.2	1.2	1.1	1.2	1.1	1.8
Taking other prescription medications	0.3	0.4	1.3	-0.2	0.6	0.4	0.6	-1.1	0.6	0.6	0.7	0.7	-0.4
Age when periods started (menarche)	0.2	0.5	3.3	-0.2	1.8	0.6	-0.2	0.9	-0.1	-0.1	-0.2	0.1	-0.7
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	2.5	-0.5	-1.6	-0.7	0.9	0.6	0.1	0.1	0.1	0.2	0.4
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.2	7.1	-2.7	-0.4	-2.3	0.7	0.1	1.9	1.8	1.9	1.8	2.2
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.5	-0.2	-0.1	-0.6	-0.5	-0.4	-0.1	0.1	0.0	-0.2	0.7
Qualifications: CSEs or equivalent	2.6	3.4	6.5	-1.4	-1.6	-2.2	-0.4	0.8	2.3	2.2	2.2	2.5	1.8
Serious illness, injury or assault to yourself	0.4	0.5	2.8	-0.5	-0.2	0.6	0.6	-1.7	0.2	0.4	0.4	0.4	-0.8
High blood pressure	1.1	3.0	26.2	0.6	-0.0	0.5	5.1	-1.3	-0.6	-0.7	-0.4	-0.9	-0.2
Hayfever, allergic rhinitis or eczema	0.9	2.0	8.5	0.5	2.6	0.8	-2.9	-1.2	-0.5	-0.5	-0.5	-0.7	-0.8
Multivitamins +/- minerals	1.1	1.4	2.4	-0.8	-0.7	-1.5	-0.2	0.6	1.4	1.5	1.6	1.3	1.3
Stomach or abdominal pain in last month	0.6	0.8	2.2	1.5	-0.7	1.2	-0.2	0.1	-0.8	-0.8	-0.7	-0.5	-1.3
Supplements: Glucosamine	0.1	0.1	1.1	-0.2	-0.3	0.2	-0.1	-1.0	0.0	0.0	0.2	-0.1	-0.0
Diverticular disease/diverticulitis (self-reported)	0.9	1.0	5.8	-0.9	-2.4	0.5	1.8	-0.2	-0.0	-0.1	0.1	0.1	-0.2
Medication: Atenolol	0.7	0.9	2.3	-0.3	-1.5	-0.8	0.7	-1.0	0.8	0.8	0.9	1.1	0.8
Medication: Levothyroxine sodium	0.2	0.3	0.9	-0.8	-0.1	-0.6	0.9	-0.0	0.6	0.6	0.5	0.6	0.5
Sitting height	0.9	6.4	15.0	-3.9	-1.6	-2.0	0.2	0.6	3.1	3.1	3.1	2.7	2.3
Chronic bronchitis/emphysema (father)	0.3	0.4	0.8	0.5	0.8	-0.1	0.9	-0.6	-0.7	-0.7	-0.8	-0.7	-0.1
High blood pressure (mother)	0.9	1.3	5.0	-0.8	-1.4	-1.6	0.2	-2.2	0.5	0.5	0.7	0.1	1.4
Body mass index (BMI)	0.8	3.5	5.2	-2.2	-0.9	-2.3	2.1	-0.7	1.8	1.8	2.0	1.8	2.3
Impedance of leg (left)	0.3	1.2	2.3	-1.1	0.1	-0.1	-1.3	1.5	1.4	1.3	1.2	1.5	0.3
Leg predicted mass (left)	0.8	4.4	6.8	-2.6	-2.1	-2.3	1.3	-0.9	2.3	2.3	2.3	2.0	2.3
Trunk fat mass	1.6	7.1	10.4	-3.2	-1.1	-3.0	1.9	-0.3	3.1	3.0	3.1	2.9	3.1
Waist circumference	1.0	3.8	6.2	-2.5	-1.0	-1.9	1.8	-1.2	2.2	2.2	2.3	1.9	2.1
Number of incorrect matches in round	0.3	0.5	1.7	0.1	-0.1	-1.3	0.6	0.0	0.5	0.6	0.5	0.5	1.2
Past tobacco smoking	0.2	0.3	1.7	0.2	1.3	0.7	0.4	-0.3	0.0	-0.0	-0.1	0.3	-0.6
Alcohol usually taken with meals	0.1	0.2	0.7	0.2	-0.4	0.8	-0.1	0.1	-0.4	-0.4	-0.2	-0.6	-0.7
Nervous feelings	0.2	0.3	1.6	-0.1	-1.3	-0.2	1.1	0.4	0.0	0.0	0.0	0.1	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	2.0	-0.1	-0.9	-0.1	-1.4	0.3	0.8	0.8	0.7	0.9	0.1
Hearing difficulty/problems with background noise	0.8	1.3	2.3	1.2	0.5	1.1	-1.1	-0.7	-1.3	-1.3	-1.2	-1.5	-1.1
Hair/balding pattern: Pattern 2	1.5	1.8	2.9	-1.6	-0.7	-1.2	-1.3	0.1	1.7	1.7	1.6	1.6	1.2
Had menopause	5.0	6.3	12.1	2.8	2.7	1.7	-0.8	-0.3	-3.1	-3.1	-3.1	-3.5	-1.7
Had other major operations	0.3	0.4	2.2	-0.4	0.8	0.3	-0.4	-1.5	0.3	0.3	0.4	0.3	-0.1
Forced vital capacity (FVC)	0.3	1.2	4.9	-0.7	-0.8	-0.8	-2.2	1.0	1.0	1.1	0.9	1.0	0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.7	4.1	-2.0	0.4	-2.0	-0.0	0.3	1.3	1.2	1.3	1.2	1.7
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.4	0.4	1.2	0.6	0.9	0.7	-0.3	-0.3	-0.4	-0.2	-0.6
Qualifications: None of the above	0.6	1.2	7.9	-0.8	0.6	-0.4	2.8	1.7	0.1	-0.1	0.2	0.4	0.1
Financial difficulties in last 2 years	0.8	1.0	4.0	0.2	-0.9	-0.6	-1.7	2.0	0.7	0.6	0.6	0.9	0.5
Mouth/teeth dental problems	2.1	3.2	6.2	-2.5	-0.7	-1.8	-1.2	1.0	2.0	2.0	1.9	2.3	1.8
Heart attack	1.7	2.2	4.3	-1.8	-1.8	-0.6	-0.8	0.6	1.8	1.7	1.8	2.1	0.8
Allergy	0.5	1.2	4.0	0.6	-1.9	0.5	2.0	0.6	-0.9	-0.9	-0.9	-0.6	-0.5
Pain all over the body in last month	0.3	0.4	1.9	-0.1	-0.6	-0.6	1.4	0.6	-0.0	-0.2	-0.0	0.1	0.7
Diabetes (self-reported)	0.2	0.3	2.6	0.4	-0.4	-0.3	1.6	0.1	-0.0	0.0	-0.0	-0.1	0.3
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	3.1	-0.2	1.8	-0.4	-1.3	-1.4	0.4	0.5	0.5	0.1	0.7
Medication: Ramipril	0.4	0.5	2.5	-0.5	-1.2	0.2	0.1	-1.6	0.1	0.1	0.2	-0.0	-0.3
Medication: Simvastatin	0.5	0.8	2.2	-1.1	-0.5	-1.4	1.5	0.1	0.4	0.5	0.5	0.5	1.1
Fluid intelligence score	0.2	0.4	3.0	0.0	0.2	-0.6	-0.7	1.7	0.1	0.2	-0.0	0.3	0.5
Illnesses of siblings	0.1	0.2	0.7	0.4	-0.0	0.8	-0.4	0.4	-0.2	-0.2	-0.3	-0.2	-0.6
Neuroticism score	0.4	0.8	2.6	-0.7	-1.6	0.3	1.0	0.5	0.9	0.8	0.8	1.1	-0.0
Weight	1.0	5.1	8.9	-3.0	-1.7	-2.4	1.7	-0.9	2.5	2.4	2.6	2.1	2.6
Impedance of arm (right)	0.2	1.0	4.3	2.1	1.1	0.8	-0.8	0.7	-0.7	-0.8	-0.9	-0.6	-0.7
Arm fat percentage (right)	0.6	2.3	3.8	-1.4	-0.4	-1.9	1.9	-0.5	1.6	1.5	1.6	1.6	1.9
Trunk fat-free mass	0.8	4.4	9.1	-3.0	-2.6	-1.9	1.4	-0.6	2.2	2.2	2.2	1.8	2.0
Hip circumference	0.5	2.3	4.5	-1.6	-1.2	-2.1	1.3	-0.2	1.5	1.5	1.6	1.2	2.1
Time employed in main current job	2.5	2.9	9.5	3.1	1.5	0.9	0.5	-0.3	-2.0	-2.0	-1.8	-2.1	-1.0
Alcohol intake versus 10 years previously	1.2	1.9	4.0	1.8	1.8	0.3	0.8	0.1	-1.6	-1.5	-1.5	-2.0	-0.5
Father’s age at death	2.2	3.0	4.8	2.2	1.8	1.1	-1.4	1.0	-2.1	-2.1	-2.1	-1.6	-1.4
Worrier / anxious feelings	0.2	0.4	1.7	0.3	-1.1	0.1	1.3	0.5	0.4	0.4	0.5	0.6	0.0
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.9	-0.1	-0.9	0.4	0.2	-0.3	0.2	0.2	0.1	0.2	-0.6
Falls in the last year	0.3	0.4	2.6	-0.3	-1.6	0.1	1.3	0.1	-0.2	-0.1	-0.1	-0.1	0.2
Hair/balding pattern: Pattern 3	0.2	0.4	2.2	0.4	0.1	-0.4	0.5	1.5	-0.5	-0.6	-0.4	-0.1	0.3
Number of live births	0.5	0.7	3.1	-0.7	0.6	0.3	0.5	1.8	0.7	0.8	0.8	0.7	-0.2
Forced expiratory volume in 1-second (FEV1)	0.4	1.2	5.5	-0.7	-0.8	-0.8	-2.3	0.8	1.0	1.1	0.8	1.0	0.8
Pulse rate	0.2	0.4	2.7	0.0	-0.1	0.1	-1.6	-0.3	0.5	0.5	0.5	0.6	-0.1
Happiness	0.4	0.5	1.2	1.1	0.1	0.7	0.6	0.3	-0.8	-0.8	-0.7	-0.9	-0.3
Noisy workplace	0.4	0.5	1.3	0.2	0.9	-1.1	0.4	0.3	-0.4	-0.4	-0.3	-0.7	1.1
Qualifications: A levels/AS levels or equivalent	0.3	0.7	2.8	-0.8	-0.1	-0.7	-1.7	-0.1	0.8	0.8	0.7	0.6	0.9
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	1.4	0.4	0.1	-0.4	-1.0	-1.2	0.0	0.1	0.2	-0.2	0.4
Mouth/teeth dental problems: Dentures	0.6	1.1	2.0	1.2	1.3	0.1	1.4	1.0	-1.1	-1.1	-1.0	-1.1	-0.2
Asthma	0.4	0.9	2.9	0.4	1.7	0.9	-0.1	-1.7	-0.3	-0.2	-0.3	-0.7	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	1.9	0.4	1.4	-1.4	0.2	0.8	0.2	0.3	0.4	0.0	1.3
Medication: Cholesterol lowering	0.6	1.0	3.8	-0.9	-0.3	-0.7	2.0	1.1	0.8	0.8	0.9	1.0	0.6
Depression (self-reported)	0.4	0.5	1.2	-1.1	-0.3	0.2	0.8	-1.0	0.7	0.7	0.7	0.4	-0.2
Medication: Lansoprazole	0.3	0.4	1.3	-0.7	-1.1	0.1	0.3	-1.0	0.4	0.4	0.4	0.1	-0.1
Prospective memory result	0.6	0.8	4.1	0.9	1.0	-0.1	2.0	0.3	-0.6	-0.7	-0.7	-0.5	0.1
Lung cancer (father)	0.2	0.2	0.4	0.4	0.5	-0.2	0.5	-0.1	-0.5	-0.4	-0.5	-0.7	-0.1
Illnesses of mother	0.5	0.6	4.0	0.6	0.4	0.7	-2.0	0.6	0.2	0.2	0.1	0.5	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.1	4.8	-0.9	-1.0	-0.8	-2.2	0.5	0.9	1.0	0.7	0.9	0.8
Pulse wave Arterial Stiffness index	0.4	0.5	0.7	-0.6	-0.8	-0.6	-0.4	0.6	0.7	0.8	0.8	0.8	0.7
Impedance of arm (left)	0.4	1.8	5.9	2.4	1.6	0.9	-1.3	0.5	-1.2	-1.2	-1.3	-1.2	-1.0
Arm fat mass (right)	1.1	4.3	6.8	-2.4	-0.8	-2.6	1.9	-0.7	2.2	2.2	2.3	2.1	2.6
Trunk predicted mass	0.8	4.3	9.1	-3.0	-2.6	-1.9	1.4	-0.5	2.1	2.2	2.2	1.8	2.1
Standing height	0.2	2.2	5.2	-2.3	-2.0	-0.8	-0.3	-0.5	1.8	1.8	1.8	1.0	1.2
Length of working week for main job	0.9	1.0	2.6	0.6	0.3	1.0	0.8	-0.7	-1.2	-1.0	-1.2	-1.6	-0.9
Exposure to tobacco smoke at home	0.7	0.8	2.5	-1.6	-0.8	-0.2	-0.1	0.7	1.1	1.0	1.1	0.8	-0.0
Breastfed as a baby	2.0	2.5	4.3	1.0	0.8	2.0	-0.5	-0.1	-1.9	-1.9	-2.0	-1.9	-2.1
Tense / ‘highly strung’	0.5	0.8	4.1	0.0	-2.0	-0.1	-0.2	0.3	0.9	0.8	0.9	1.1	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	2.3	-0.8	-1.4	-0.7	1.5	-0.5	1.2	1.1	1.4	1.1	0.6
Hair/balding pattern: Pattern 4	0.2	0.6	0.9	-0.8	-0.7	-1.0	0.1	0.4	0.9	0.9	0.8	0.7	0.9
Birth weight of first child	0.1	0.2	1.0	0.6	1.0	-0.0	0.3	0.7	-0.3	-0.3	-0.2	-0.1	-0.1
Peak expiratory flow (PEF)	0.8	1.8	3.9	-1.4	-2.0	-0.9	-1.4	-0.3	1.5	1.6	1.4	1.1	1.0
Pulse wave reflection index	0.5	0.6	1.2	-0.6	-0.2	-1.1	-0.3	1.0	0.6	0.6	0.7	0.7	1.1
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.8	0.9	0.7	0.5	0.5	0.8	-0.1	-0.1	0.1	0.1	-0.2
Loud music exposure frequency	1.9	2.1	3.2	-1.7	-0.6	-1.6	-0.2	0.3	1.8	1.7	1.8	1.4	1.8
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	5.5	-1.2	-1.5	0.2	-2.3	-0.4	1.5	1.5	1.4	1.3	0.1
Mouth/teeth dental problems: Bleeding gums	1.5	1.9	2.9	1.3	-0.9	1.5	-1.2	-1.7	-1.4	-1.4	-1.4	-1.5	-1.5
Blood clot in the leg (DVT)	1.4	1.7	2.7	-1.2	-0.1	-1.6	0.3	1.1	1.6	1.6	1.6	1.5	1.5
Medication: Paracetamol	0.5	0.8	4.9	-0.3	-1.0	-0.3	2.2	0.6	0.6	0.5	0.6	0.5	0.3
Headache pain in last month	0.0	0.1	0.2	0.1	-0.0	-0.2	0.2	0.1	0.3	0.4	0.4	0.5	0.1
Medication for cholesterol, blood pressure or diabetes	0.9	1.4	8.8	1.3	0.6	0.5	-3.0	-0.4	-0.8	-0.7	-0.9	-0.8	-0.4
Glaucoma (self-reported)	2.7	3.1	5.7	-2.3	-1.5	-1.2	0.5	0.0	2.3	2.2	2.2	2.4	1.3
Gout (self-reported)	1.0	1.4	2.2	-1.0	1.4	-1.4	1.2	0.9	1.1	1.1	1.2	1.0	1.5
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	1.9	-1.4	-0.5	-1.1	0.6	1.1	1.0	1.0	0.9	1.0	1.2
Medication: Amlodipine	0.7	1.0	4.7	0.1	1.3	0.8	2.2	-1.6	-0.1	-0.1	-0.0	-0.3	-0.6
Medication: Ventolin 100micrograms inhaler	1.1	1.4	2.0	1.1	0.5	1.2	1.2	-0.3	-1.4	-1.3	-1.4	-1.4	-1.4
Birth weight	1.6	3.4	5.7	-1.8	-2.1	-1.4	0.3	-0.9	2.4	2.3	2.4	2.2	1.5
Chronic bronchitis/emphysema (mother)	0.5	0.5	2.0	-0.2	1.4	-0.4	0.6	-1.2	-0.5	-0.5	-0.4	-0.8	0.3
High blood pressure (siblings)	0.3	0.4	1.3	0.2	-1.1	-0.9	0.7	-0.8	-0.4	-0.5	-0.3	-0.4	0.6
Forced vital capacity (FVC), Best measure	0.1	0.5	2.1	-0.5	-0.7	-0.4	-1.4	0.6	0.7	0.7	0.5	0.6	0.4
Body fat percentage	1.2	4.9	6.8	-2.5	-0.6	-2.6	1.6	-0.1	2.6	2.5	2.5	2.6	2.6
Leg fat percentage (right)	1.8	6.7	9.9	-3.1	-1.1	-2.7	1.9	-0.1	3.0	3.0	3.0	3.1	2.8
Arm fat-free mass (right)	1.1	5.8	12.8	-3.6	-2.5	-2.3	1.0	-0.7	2.7	2.7	2.7	2.2	2.4
Exposure to tobacco smoke outside home	0.5	0.7	2.6	-1.3	-0.7	0.1	-1.6	-0.9	0.5	0.5	0.7	0.5	-0.5
Comparative body size at age 10	0.1	0.3	0.9	0.4	-0.1	-0.3	1.0	0.6	-0.7	-0.7	-0.7	-0.6	0.3
Number of full brothers	0.4	0.5	2.5	-1.0	-1.6	0.5	-0.5	0.6	0.2	0.2	0.2	0.3	-0.6
Worry too long after embarrassment	0.3	0.5	2.2	0.3	-0.1	1.5	-0.2	-0.0	-0.5	-0.5	-0.7	-0.4	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	4.0	0.4	-0.0	-0.3	2.0	1.1	-0.1	-0.2	0.0	-0.0	0.5
Wheeze or whistling in the chest in last year	0.7	1.3	2.3	1.5	0.8	1.3	0.6	0.0	-1.2	-1.2	-1.2	-0.9	-1.5
Number of children fathered	0.6	0.7	3.6	-0.0	-1.0	0.3	1.9	-0.9	-0.5	-0.4	-0.5	-0.8	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	1.1	-0.2	-0.5	-0.6	-0.4	1.0	0.1	0.0	0.1	0.2	0.5
Age at first live birth	0.4	0.6	1.6	-0.6	-0.5	-0.3	-1.2	0.8	0.8	0.8	0.7	1.2	0.4
Pulse wave peak to peak time	0.3	0.3	0.6	0.5	0.5	0.4	0.3	-0.5	-0.6	-0.7	-0.7	-0.8	-0.5
Health satisfaction	1.2	1.5	4.0	1.4	-0.4	2.0	0.4	-0.7	-1.1	-1.1	-1.2	-0.9	-2.0
Shortness of breath walking on level ground	0.2	0.3	0.9	0.6	-0.9	0.5	0.7	0.2	0.0	-0.1	-0.0	0.3	-0.8
Qualifications: College or University degree	0.3	1.1	2.4	1.2	0.0	1.1	-1.6	0.6	-1.1	-1.0	-1.0	-1.2	-0.8
Eye problems/disorders: None of the above	0.5	0.5	2.5	-0.6	0.5	-0.7	-1.6	-0.4	0.6	0.6	0.6	0.2	0.6
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.6	0.1	-0.7	-0.2	0.4	-0.8	0.0	-0.0	0.1	-0.3	0.3
Emphysema/chronic bronchitis	0.2	0.2	1.1	0.0	-0.6	-1.0	0.1	0.4	-0.0	0.1	-0.1	-0.2	0.9
Medication for pain relief, constipation, heartburn	0.1	0.2	0.7	-0.5	0.3	0.6	-0.8	-0.2	-0.1	-0.1	-0.4	-0.1	-0.4
Neck or shoulder pain in last month	1.1	1.5	2.4	1.5	-0.5	1.5	-0.4	-1.1	-1.4	-1.2	-1.2	-1.3	-1.5
Medication: Blood pressure	1.1	2.0	11.9	-1.4	-1.7	-0.3	3.5	-0.8	0.7	0.7	1.0	0.4	0.6
Angina (self-reported)	0.7	0.9	3.4	0.7	-0.8	1.2	1.9	-0.3	-0.7	-0.7	-0.6	-0.5	-1.2
Migraine (self-reported)	0.3	0.4	1.3	-0.5	-0.3	-0.2	0.4	-1.2	0.7	0.8	0.9	0.5	0.4
Medication: Ibuprofen	0.4	0.5	2.0	0.6	1.4	-0.9	0.2	0.7	-0.0	0.0	0.2	-0.2	0.9
Medication: Allopurinol	0.8	1.1	5.1	-0.4	2.3	-1.1	0.8	0.9	0.7	0.7	0.7	0.6	1.1
Medication: Omeprazole	0.7	0.9	7.7	-0.2	-2.8	0.2	-0.3	-0.4	0.3	0.3	0.4	0.5	-0.3
Medication: Seretide 50 evohaler	0.1	0.1	0.3	0.1	0.6	-0.2	0.2	0.2	0.1	0.1	0.2	-0.1	0.3
Mean time to correctly identify matches	0.7	1.2	1.8	1.3	-0.7	1.0	-0.7	-1.2	-1.3	-1.3	-1.2	-1.3	-0.9
Heart disease (mother)	1.1	1.4	4.3	-1.4	-0.4	-1.3	2.1	-0.9	0.8	0.9	0.9	0.5	1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.5	0.5	0.4	0.3	0.2	0.7	-0.4	-0.5	-0.3	-0.1	-0.4
Whole body fat mass	1.5	6.3	9.2	-3.0	-1.2	-2.9	1.6	-0.5	2.9	2.8	2.9	2.7	3.0
Leg fat mass (right)	2.2	8.5	12.9	-3.6	-1.7	-3.1	1.9	-0.5	3.4	3.3	3.4	3.3	3.2
Arm predicted mass (right)	1.3	6.5	14.4	-3.8	-2.7	-2.4	1.0	-0.6	2.8	2.8	2.9	2.4	2.6
Pulse rate, automated reading	0.3	0.9	3.1	-0.3	-1.8	-0.7	-1.2	-0.4	1.0	0.9	0.9	1.0	0.6
Alcohol intake frequency.	1.8	4.1	6.8	2.6	1.9	2.1	1.9	0.3	-2.1	-2.2	-2.1	-2.1	-2.0
Comparative height size at age 10	0.5	2.5	8.1	-1.9	-2.8	-1.1	0.6	0.1	1.6	1.7	1.8	1.3	1.2
Number of full sisters	0.2	0.2	0.8	-0.7	-0.1	-0.2	-0.2	-0.9	0.4	0.4	0.3	0.3	0.1
Suffer from ‘nerves’	0.6	0.9	2.3	-0.8	-1.5	-0.6	1.1	1.0	0.9	0.8	0.7	1.0	0.9
Overall health rating	0.5	1.1	1.8	-1.0	-1.0	-0.8	1.4	-0.2	1.1	1.2	1.2	1.1	0.9
Chest pain or discomfort	0.2	0.3	0.5	-0.5	-0.5	-0.1	-0.1	-0.6	0.7	0.7	0.7	0.6	0.1
Had major operations	0.6	0.8	2.2	-0.4	0.2	-1.0	1.5	1.2	0.7	0.7	0.7	0.7	0.9
Age at last live birth	1.1	1.7	3.2	-1.1	0.0	-1.0	-1.7	1.1	1.4	1.3	1.5	1.8	1.1
Family relationship satisfaction	0.4	0.5	1.6	1.2	0.6	0.8	-0.8	0.7	-0.5	-0.6	-0.5	-0.3	-0.7
Leg pain on walking	0.8	1.0	3.0	1.1	0.4	1.7	0.7	1.5	-0.3	-0.3	-0.4	0.1	-1.7
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	2.0	0.1	-0.2	-0.4	-1.4	-1.1	0.1	0.1	0.0	0.2	0.3
Commuting to job workplace: Car/motor vehicle	0.4	0.5	2.3	-0.1	-1.4	0.3	1.5	0.2	-0.3	-0.3	-0.3	-0.2	-0.1
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.8	0.4	0.6	-0.3	0.9	0.1	-0.4	-0.5	-0.5	-0.6	0.3
Medication: Aspirin	0.1	0.2	1.1	0.1	-0.7	0.1	1.0	-0.1	0.0	-0.0	0.2	0.3	-0.1
Supplements: Vitamin C	0.1	0.2	1.3	0.2	1.2	-0.2	-0.4	0.4	-0.1	-0.0	0.0	0.2	0.1
Knee pain experienced in last month	0.6	0.9	2.4	0.8	0.2	1.1	-0.4	-1.6	-0.9	-0.9	-0.8	-0.6	-1.3
Hypertension (Self-reported)	1.2	3.2	24.1	0.7	-0.2	0.9	4.9	-1.4	-1.0	-1.0	-0.8	-1.3	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.6	0.6	-1.0	0.6	-1.3	-0.3	-0.7	-0.8	-0.7	-0.8	-0.8
Illnesses of father: Heart disease	0.5	0.7	1.7	-0.5	0.1	-0.2	0.9	0.2	1.2	1.2	1.2	1.3	0.2
Illnesses of siblings: Diabetes	0.3	0.3	1.2	-0.2	1.1	-0.2	-0.3	1.1	0.3	0.3	0.4	0.4	0.2
Smoking status: Previous	0.2	0.3	1.3	-0.5	-1.2	-0.9	0.1	0.2	0.2	0.2	0.3	-0.1	0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.8	4.2	-2.0	-1.1	-1.1	-0.0	0.6	1.6	1.6	1.4	1.4	1.3
Whole body fat-free mass	0.8	4.8	9.1	-3.0	-2.5	-2.2	1.3	-0.7	2.3	2.3	2.4	1.9	2.3
Leg fat-free mass (right)	0.6	3.4	5.7	-2.4	-2.1	-2.0	1.0	-1.1	1.9	2.0	2.0	1.6	2.0
Arm fat percentage (left)	0.5	2.1	3.6	-1.3	-0.4	-1.9	1.8	-0.7	1.5	1.4	1.5	1.5	1.9
Average weekly red wine intake	0.7	1.0	4.4	0.1	-2.1	-0.3	-1.8	1.3	0.1	0.1	0.0	0.2	0.3
Handedness (chirality/laterality): Left-handed	0.5	0.6	2.6	0.2	1.6	0.2	0.9	0.1	0.7	0.6	0.4	1.0	-0.2
Mood swings	0.1	0.1	0.3	-0.1	-0.4	0.5	0.4	0.5	0.0	-0.1	-0.1	0.1	-0.5
Loneliness, isolation	0.3	0.4	1.3	-0.1	-1.0	1.2	-0.2	-0.2	0.1	0.0	0.0	0.2	-1.0
Long-standing illness, disability or infirmity	0.9	1.3	3.2	0.7	-0.2	1.7	1.8	-0.8	-0.9	-1.0	-0.8	-1.0	-1.6
Ever had bowel cancer screening	4.4	5.2	6.5	2.2	2.2	2.5	1.9	-2.2	-2.2	-2.2	-2.2	-2.5	-2.5
Diabetes diagnosed by doctor	0.2	0.3	2.3	-0.1	-0.8	-0.4	1.5	-0.3	0.2	0.2	0.3	0.1	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	1.0	-1.0	-1.0	-0.6	-0.3	-0.1	0.2	0.2	0.2	-0.0	0.4
Friendships satisfaction	0.5	0.6	1.3	1.1	0.7	0.8	0.3	1.1	-0.8	-0.8	-0.6	-0.6	-0.9
Qualifications: nursing, teaching	0.1	0.1	0.8	0.2	-0.4	0.0	-0.9	0.5	-0.1	-0.0	-0.1	-0.2	0.1
Commuting to job workplace: Walk	0.6	0.6	4.2	0.4	0.3	0.6	-2.0	-0.1	-0.6	-0.6	-0.4	-0.6	-0.5
Eye problems/disorders: Cataract	0.5	0.5	3.1	0.9	-0.5	0.5	1.8	0.0	-0.4	-0.4	-0.4	-0.2	-0.5
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	4.9	0.8	0.7	2.2	1.9	0.5	-0.8	-0.8	-0.7	-0.8	-1.9
Medication for cholesterol	0.6	0.9	7.1	0.2	0.5	0.1	-1.3	2.7	0.1	0.1	-0.0	0.3	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.7	-0.8	-0.8	0.6	0.4	-0.1	0.5	0.3	0.5	0.6	-0.5
Back pain experienced in last month	0.4	0.5	2.1	0.6	-0.8	-0.1	-1.5	-1.4	0.2	0.3	0.3	-0.1	0.1
Mineral and other dietary supplements	0.3	0.3	1.5	0.1	-0.8	0.1	0.9	1.2	-0.0	-0.2	-0.3	0.2	-0.3
Breast cancer (self-reported)	0.7	0.8	1.2	0.8	-0.9	1.1	0.9	-0.8	-0.9	-0.9	-0.8	-0.9	-1.1
Asthma (self-reported)	0.5	1.1	2.9	0.6	1.7	1.2	0.0	-1.7	-0.4	-0.3	-0.4	-0.9	-1.3
Osteoporosis (self-reported)	0.6	0.8	6.2	0.1	-0.5	0.8	-2.5	0.5	-0.2	-0.1	-0.1	-0.3	-0.7
Osteoarthritis (self-reported)	1.2	1.6	3.1	1.3	0.2	0.9	1.0	-0.6	-1.8	-1.8	-1.6	-1.6	-1.1
Medication: Aspirin	0.2	0.3	2.2	0.3	-0.5	0.1	1.5	0.1	-0.1	-0.1	0.0	0.2	-0.1
Medication: Gliclazide	0.5	0.6	1.2	-0.8	0.1	-0.7	-0.0	0.7	1.0	1.0	0.8	1.1	0.7
Illnesses of father: None of the above (group 1)	1.1	1.4	2.4	0.8	0.4	1.0	-1.1	0.4	-1.6	-1.5	-1.6	-1.5	-1.0
Smoking status: Current	0.1	0.2	1.9	0.3	0.1	-0.2	0.1	1.4	0.1	-0.0	-0.1	0.5	0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.4	1.1	-0.5	0.7	-0.7	0.3	-1.1	-1.0	-1.2	-0.9	-0.9
Whole body water mass	0.8	4.3	8.5	-2.9	-2.4	-2.0	1.4	-0.7	2.2	2.2	2.2	1.8	2.1
Leg predicted mass (right)	0.6	3.4	5.6	-2.4	-2.1	-2.0	1.1	-1.0	1.9	1.9	2.0	1.5	2.0
Arm fat mass (left)	0.8	3.3	5.1	-2.1	-0.9	-2.2	1.9	-1.0	1.9	1.8	2.0	1.7	2.3
Number of self-reported non-cancer illnesses	0.9	1.6	3.2	1.3	1.4	0.8	1.7	-1.8	-1.1	-1.1	-0.8	-1.4	-0.8
Average weekly champagne plus white wine intake	1.8	2.4	3.2	-1.8	-0.4	-1.7	-1.6	0.9	1.8	1.7	1.8	1.6	1.7
Miserableness	0.4	0.6	1.4	-0.4	-0.8	-0.3	1.2	0.6	0.9	0.8	1.0	1.0	0.2
Guilty feelings	1.2	1.8	3.2	1.1	0.7	1.8	0.9	-0.1	-1.5	-1.5	-1.6	-1.3	-1.8
Wears glasses or contact lenses	1.6	1.8	3.5	1.5	1.9	1.0	0.2	-1.2	-1.5	-1.4	-1.4	-1.8	-0.7
Ever taken oral contraceptive pill	0.6	0.6	1.6	-0.8	-0.1	-0.9	-0.4	1.3	0.8	0.9	0.7	1.0	0.6
Hearing aid user	0.2	0.2	0.9	-0.6	-0.6	0.0	-0.2	-1.0	0.2	0.1	0.3	0.2	0.0
Mother’s age at death	0.5	0.6	2.7	-0.7	1.5	0.4	-1.7	-0.6	0.3	0.2	0.2	0.3	-0.2
Financial situation satisfaction	0.3	0.4	3.0	0.1	-0.5	-0.0	-1.7	0.5	0.3	0.3	0.1	0.5	-0.0
Tinnitus: Yes, now most or all of the time	0.4	0.4	1.5	0.9	-0.1	0.3	-1.2	0.8	-0.4	-0.4	-0.3	-0.6	-0.5
Commuting to job workplace: Public transport	0.2	0.2	1.0	-0.3	1.0	0.2	-0.0	-0.8	0.4	0.4	0.5	0.1	0.0
Eye problems/disorders: Glaucoma	3.5	4.1	6.0	-2.3	-2.4	-1.9	-0.2	-0.2	2.5	2.4	2.4	2.4	1.9
Medication: Blood pressure	1.3	2.4	6.0	1.2	0.1	1.1	2.5	-2.4	-1.5	-1.4	-1.4	-1.8	-0.9
Pain type(s) experienced in last month: Hip pain	0.2	0.3	1.7	0.6	1.3	-0.3	0.2	0.7	0.1	0.0	0.2	0.1	-0.0
Supplements: Fish oil (including cod liver oil)	0.3	0.4	2.0	0.4	1.4	0.4	-0.6	-0.4	-0.5	-0.4	-0.3	-0.6	-0.3
High cholesterol (Self-reported)	0.3	0.5	1.5	-0.6	-0.7	-0.9	1.2	0.3	0.6	0.5	0.6	0.6	0.9
Medication: Bendroflumethiazide	1.1	1.7	12.3	0.3	-0.1	1.3	3.5	0.0	-0.6	-0.7	-0.6	-0.8	-1.1
Medication: Paracetamol	0.5	0.8	3.5	-0.8	-1.2	-0.5	1.9	0.3	0.7	0.7	0.8	0.8	0.4
Medication: Lisinopril	0.4	0.6	2.1	-0.8	1.0	-0.6	1.4	0.0	-0.3	-0.3	-0.3	-0.9	0.8
Medication: Atorvastatin	1.6	2.0	3.7	-1.4	-0.9	-0.5	1.6	-0.6	1.8	1.8	1.9	1.7	0.8
Illnesses of father: High blood pressure	1.3	1.6	3.0	-1.2	-1.7	-1.4	-0.2	0.1	1.5	1.4	1.6	1.4	1.2
Alcohol drinker status: Never	0.7	0.8	3.1	1.0	-0.8	1.8	0.3	0.3	-0.4	-0.5	-0.4	-0.3	-1.6
Ever smoked	0.4	0.7	2.8	-0.6	-1.7	-0.6	-1.1	1.2	0.4	0.4	0.4	0.3	0.6
Basal metabolic rate	0.9	5.1	9.5	-3.1	-2.3	-2.3	1.4	-0.7	2.5	2.5	2.5	2.1	2.4
Leg fat percentage (left)	1.7	6.3	10.3	-3.2	-1.2	-2.6	1.6	-0.3	2.9	2.9	2.9	2.9	2.8
Arm fat-free mass (left)	0.9	4.4	10.2	-3.2	-2.3	-2.0	1.2	-0.7	2.2	2.2	2.2	1.8	2.2
Number of operations (self-reported)	0.6	0.9	2.0	-1.2	-0.7	-0.8	1.4	-0.4	0.9	0.8	0.9	0.9	0.9
Average weekly beer plus cider intake	2.4	3.4	7.8	-1.6	0.5	-2.8	0.0	0.4	2.1	2.1	2.1	2.1	2.4
Irritability	0.4	0.7	5.3	0.0	-2.3	0.6	0.8	0.4	-0.1	-0.2	-0.2	-0.0	-0.4
Risk taking	1.4	2.1	5.9	-0.9	-0.2	-1.1	-2.4	-0.3	1.7	1.6	1.7	1.6	1.3
Ever had prostate specific antigen (PSA) test	0.6	0.6	1.8	1.1	-1.3	-0.1	0.6	0.8	-0.8	-0.8	-1.0	-0.3	-0.1
Fractured/broken bones in last 5 years	0.3	0.3	2.1	-0.5	-1.4	-0.1	-1.0	0.3	0.2	0.2	0.1	0.1	0.2
Age started oral contraceptive pill	0.9	1.1	2.0	1.2	1.0	1.0	-0.7	-1.4	-1.0	-0.9	-0.9	-1.2	-1.0
Diastolic blood pressure, automated reading	0.3	0.8	1.7	-0.4	0.5	-1.2	-1.3	-0.2	0.9	0.8	0.9	1.1	1.0
Ever depressed for a whole week	0.3	0.4	1.1	1.1	0.7	0.6	-0.5	0.3	-0.6	-0.6	-0.5	-0.5	-0.6
Unable to work because of sickness or disability	2.6	3.4	5.6	-2.2	-0.2	-2.0	0.8	-0.3	2.3	2.2	2.4	2.1	2.0
Commuting to job workplace: Cycle	0.7	0.8	2.5	1.6	-0.0	0.4	-0.8	0.6	-1.0	-0.9	-1.1	-1.1	-0.2
Myopia	0.8	1.1	2.4	1.2	0.7	1.6	-0.4	0.3	-1.0	-0.9	-1.1	-1.1	-1.5
Vascular/heart problems diagnosed by doctor	1.0	2.8	24.1	-0.6	0.2	-0.5	-4.9	1.4	0.6	0.6	0.3	0.8	0.2
Cholesterol lowering medication	0.7	1.0	2.9	-0.5	-1.4	-1.0	1.7	-1.4	0.5	0.6	0.7	0.3	1.0
Medication: Omeprazole (e.g. Zanprol)	0.4	0.4	2.8	-0.1	-1.7	0.2	-0.9	-0.5	0.3	0.2	0.3	0.4	-0.4
Pain experienced in last month	0.4	0.7	1.6	-1.2	0.5	-0.6	0.9	1.2	0.9	0.8	0.5	0.8	0.7
Supplements: Calcium	0.7	0.7	1.1	0.7	1.0	0.6	-1.0	-0.5	-1.0	-1.0	-0.9	-1.0	-0.6
Basal cell carcinoma (self-reported)	2.5	2.9	5.3	1.9	1.1	2.3	0.6	0.2	-1.8	-1.9	-2.0	-1.6	-2.3
Heart attack/myocardial infarction (self-reported)	2.3	3.0	5.6	-2.0	-2.4	-0.9	-0.9	0.6	2.0	2.0	2.0	2.4	1.1
Deep venous thrombosis (DVT) (self-reported)	1.6	2.1	3.4	-1.4	-0.2	-1.6	0.3	1.0	1.8	1.9	1.8	1.7	1.6
Heart disease (siblings)	0.2	0.2	1.0	-0.7	0.2	-0.5	-0.5	-1.0	0.2	0.1	0.2	0.0	0.2
Alcohol drinker status: Previous	0.4	0.4	3.7	-0.1	0.4	0.2	1.9	0.6	-0.2	-0.1	0.0	-0.2	-0.2
Pack years of smoking	0.9	1.4	2.9	-0.7	-1.6	-0.5	0.2	1.5	1.3	1.2	1.2	1.7	0.6
Impedance of whole body	0.1	0.6	2.1	0.9	1.0	0.3	-1.5	1.2	-0.0	-0.0	-0.2	0.0	-0.3
Leg fat mass (left)	2.1	8.3	13.2	-3.6	-1.8	-3.1	1.6	-0.6	3.4	3.3	3.4	3.2	3.2
Arm predicted mass (left)	1.1	5.4	12.3	-3.5	-2.4	-2.2	1.4	-0.7	2.5	2.5	2.6	2.0	2.4