Hub : Genes

ALOX12

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Breast Mammary Tissue 0.2320 0.0680 1.5e-03 0.121 NA 0.129 NA 0.139 9.2e-07 NA 4.0e-07 NA 1.2e-07
2 GTEx Breast Mammary Tissue (Female) 0.0481 0.1096 3.7e-01 -0.009 NA 0.004 NA -0.010 8.1e-01 NA 2.4e-01 NA 9.7e-01
3 GTEx Colon Transverse 0.1880 0.0620 3.4e-03 0.159 NA 0.154 NA 0.161 5.3e-08 NA 8.3e-08 NA 4.2e-08
4 NTR Blood 0.0238 0.0099 2.7e-03 0.008 0.005 0.006 0.005 0.011 1.1e-03 9.7e-03 4.3e-03 9.0e-03 1.5e-04
5 YFS Blood 0.0534 0.0147 6.6e-06 0.022 0.023 0.036 0.042 0.041 5.2e-08 3.7e-08 5.1e-12 1.5e-13 2.0e-13
6 TCGA Bladder Urothelial Carcinoma 0.0990 0.0360 1.1e-07 0.123 0.098 0.109 NA 0.113 1.4e-10 1.2e-08 1.8e-09 NA 8.3e-10
7 TCGA Cervical Squamous Cell Carcinoma 0.1560 0.0690 1.3e-03 0.080 0.043 0.037 NA 0.058 9.6e-05 3.3e-03 6.6e-03 NA 7.8e-04
8 TCGA Head and Neck Squamous Cell Carcinoma 0.1014 0.0358 2.2e-09 0.102 0.086 0.100 NA 0.106 1.6e-11 7.1e-10 2.4e-11 NA 6.8e-12
9 TCGA Lung Squamous Cell Carcinoma 0.0451 0.0185 1.4e-05 0.060 0.045 0.057 NA 0.055 2.3e-07 7.7e-06 4.7e-07 NA 7.0e-07
10 TCGA Ovarian Serous Cystadenocarcinoma 0.0670 0.0340 1.3e-03 0.053 0.014 0.022 NA 0.048 1.7e-04 3.7e-02 1.2e-02 NA 3.6e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bipolar Disorder (2018) 1.4 2.2 4.4 1.5 1.9 2.1 0.2 -0.0 -1.4 -1.4 -1.3 -1.3 -2.1
Bipolar Disorder or Schizophrenia 1.0 2.3 6.8 1.9 2.6 1.7 0.6 -1.8 -1.0 -0.9 -1.0 -1.2 -1.4
Depressed Affect (Nagel 2018) 0.4 0.8 2.5 -0.7 -1.2 -0.0 1.6 1.4 0.6 0.4 0.7 0.8 0.1
Depression (Nagel 2018) 0.1 0.2 0.7 -0.4 -0.1 0.1 -0.2 0.9 0.5 0.4 0.5 0.6 -0.1
Intelligence (Savage-Jansen 2018) 0.5 1.5 2.5 1.6 1.0 1.0 -0.4 0.8 -1.5 -1.5 -1.4 -1.5 -0.9
Neuroticism (Nagel 2018) 0.5 1.1 5.1 -0.5 -2.3 0.2 1.3 1.5 0.6 0.3 0.5 0.9 -0.1
Schizophrenia (2018) 0.5 1.1 5.3 1.2 1.9 0.4 0.7 -2.3 -0.2 -0.1 -0.2 -0.4 -0.2
Schizophrenia vs Biploar Disorder 2.5 3.2 5.3 -1.6 -0.1 -2.1 1.3 0.3 2.2 2.3 1.8 2.1 2.3
Worry (Nagel 2018) 0.2 0.5 2.0 0.1 -1.0 -0.1 1.4 1.1 0.3 0.2 0.3 0.7 0.2
Alzheimer’s Disease (in mother) 0.6 0.7 1.5 1.2 -0.2 0.6 0.7 -0.5 -1.0 -0.9 -1.0 -1.2 -0.4
Alzheimer’s Disease (in father) 0.2 0.2 1.4 -0.3 -0.3 0.1 -0.2 -1.2 0.2 0.2 0.3 -0.1 0.2
Alzheimer’s Disease (including proxy) 0.6 0.9 2.1 1.2 -0.3 1.0 0.6 -1.5 -0.9 -0.7 -0.8 -1.3 -0.7
Crohns Disease (2017) 0.4 0.9 6.8 -0.5 -0.5 0.5 2.6 0.1 0.6 0.5 0.5 0.6 -0.1
Irritable Bowel Disease (IBD) 0.2 0.5 2.0 0.3 0.2 1.3 1.4 0.0 -0.4 -0.4 -0.4 -0.1 -1.1
Ulcerative Colitis (UC) 0.5 0.9 2.2 0.8 1.0 1.3 -0.1 -0.2 -1.1 -0.9 -1.0 -0.8 -1.5
Major Depression (MDD) 0.2 0.3 1.0 0.0 0.9 -0.1 1.0 -0.7 0.2 0.1 0.3 0.2 0.3
Reaction Time 0.1 0.2 1.2 0.4 -1.1 0.0 -0.4 -0.5 -0.2 -0.2 -0.2 -0.1 0.1
Verbal and Numeric Reasoning (VNR) 0.3 0.7 3.8 0.7 0.9 0.3 -0.0 1.9 -0.7 -0.7 -0.8 -0.3 -0.5
Breast Cancer 0.5 1.3 6.9 0.4 -0.6 -0.6 2.6 1.9 -0.7 -0.7 -0.8 -0.4 0.4
Ovarian Cancer 0.5 0.7 2.9 -0.8 -0.7 -1.4 0.2 0.9 0.1 0.0 0.4 0.0 1.7
Prostate Cancer 0.7 1.0 2.4 -1.1 0.3 -0.7 -1.1 1.6 0.8 0.7 0.8 1.4 0.5
Age at First Birth 0.1 0.1 0.4 -0.2 0.1 -0.3 -0.6 -0.4 0.1 0.5 0.4 0.1 0.5
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 1.0 1.4 3.2 -0.8 0.1 -1.6 1.8 1.0 1.0 1.1 1.0 0.8 1.8
Coronary Artery Disease (CAD) 0.0 0.0 0.3 0.0 0.0 0.0 0.5 -0.1 0.0 0.0 0.0 0.0 0.0
Crohns Disease (2012) 0.9 1.4 3.3 0.7 0.1 1.5 1.8 -0.1 -1.2 -1.2 -1.3 -1.2 -1.2
Mean Putamen Volume 0.8 0.9 4.1 -1.1 -0.5 -0.3 0.8 -2.0 0.7 0.9 0.9 0.6 0.5
Fasting Glucose 1.1 1.3 2.9 -1.4 -0.4 -1.2 -0.1 1.7 1.1 1.2 1.0 1.2 1.2
HbA1C 0.3 0.3 2.3 -0.1 0.4 -0.2 -0.3 1.5 -0.3 0.2 -0.2 0.3 0.1
HDL Cholesterol 0.2 0.4 2.0 -0.0 1.0 -0.4 -0.8 1.4 0.2 -0.2 0.0 0.2 0.5
LDL Cholesterol 0.1 0.2 0.7 0.0 -0.2 -0.7 -0.8 0.4 0.5 0.4 0.3 0.3 0.6
Lupus 0.3 0.5 3.1 -0.1 0.4 -0.4 -0.3 1.8 -0.6 -0.6 -0.7 -0.5 -0.0
Neuroticism (2016) 0.2 0.3 1.4 0.4 -0.0 0.9 0.0 0.0 -0.6 -0.5 -0.5 -0.3 -1.2
Primary Biliary Cirrhosis 0.9 1.3 3.7 0.5 0.0 1.8 -1.0 -1.9 -0.6 -0.6 -0.6 -0.7 -1.7
Rheumatoid Arthritis 0.1 0.2 0.7 0.8 0.1 -0.6 0.2 0.3 -0.2 -0.1 -0.2 -0.1 0.6
Schizophrenia (2014) 0.7 1.5 3.6 1.2 1.6 1.4 1.6 -1.9 -0.6 -0.6 -0.7 -0.6 -1.0
Triglycerides 1.6 2.7 4.1 -1.9 -0.6 -1.7 -1.1 0.2 1.9 2.0 2.0 2.0 1.6
Type 2 Diabetes (T2D) (2012) 0.2 0.2 1.3 0.1 -0.3 0.2 -0.2 -1.1 0.4 0.0 0.3 0.2 -0.3
Ulcerative Colitis 0.7 1.0 2.5 0.8 0.2 1.4 -0.4 -0.0 -1.2 -1.2 -1.1 -0.9 -1.6
Blood Eosinophil Count 0.0 0.2 0.6 0.5 -0.8 0.4 0.7 -0.4 -0.3 -0.3 -0.3 -0.2 -0.2
Blood Platelet Count 0.3 3.0 6.2 0.8 -2.4 2.5 -0.8 -2.0 -1.3 -1.3 -1.5 -1.0 -2.4
Blood Red Count 0.2 2.0 3.3 -1.8 -0.7 -0.9 0.4 -1.8 1.7 1.6 1.8 1.5 1.0
Blood White Count 0.4 2.9 10.8 0.8 -3.3 1.8 2.8 0.2 -0.9 -1.1 -1.0 -0.3 -1.7
Heel T-Score 0.1 1.0 3.7 -1.6 -1.5 -0.2 1.0 -1.9 0.2 0.3 0.5 0.0 0.2
BMI 0.5 3.0 6.6 -2.6 -0.2 -1.7 1.4 -0.0 1.9 1.9 2.0 2.0 1.7
Height 0.0 0.7 2.4 -1.6 -0.2 1.1 -0.1 -1.3 0.5 0.5 0.4 -0.3 -0.7
Waist Hip Ratio (WHR) 0.3 1.1 2.1 -1.5 -1.2 -0.4 1.0 -0.7 1.2 1.3 1.2 0.9 0.7
Systolic Blood Pressure 0.7 3.7 25.1 0.0 2.9 -0.3 5.0 -0.1 0.7 0.7 0.8 0.8 0.7
Smoking Status 0.2 0.5 2.4 0.6 -1.1 -0.3 0.5 1.6 -0.3 -0.4 -0.4 -0.1 0.2
Allergy or Eczema 0.6 1.5 6.1 0.1 1.7 1.0 -2.5 -1.6 -0.4 -0.5 -0.5 -0.8 -0.9
Cardiovascular Disease 0.4 1.4 12.7 -0.4 -0.1 -0.3 3.6 -0.6 0.5 0.4 0.5 0.5 0.5
Hypothyroidism (self reported) 0.2 0.5 1.0 -0.9 1.0 -0.6 -0.6 0.9 0.5 0.4 0.3 0.4 0.7
Respiratory disease 0.1 0.3 2.4 0.2 0.3 -0.0 -0.6 -1.5 0.0 0.1 0.1 -0.4 -0.1
Type 2 Diabetes (T2D) (2018) 0.2 0.4 1.0 -0.7 -0.8 -0.4 1.0 -0.3 0.7 0.7 0.6 0.5 0.5
Lung FEV1/FVC ratio 0.1 0.5 1.9 -1.2 -0.5 -0.5 0.0 -1.4 0.5 0.5 0.3 0.5 0.3
Lung FVC 0.1 0.6 4.5 0.1 0.3 -0.3 -2.1 1.2 0.1 0.1 -0.1 0.5 0.1
Neuroticism 0.5 1.2 2.8 -1.1 -1.5 0.0 1.7 1.6 0.9 0.8 0.9 1.1 0.2
Chronotype (morning person) 0.2 0.4 1.3 0.6 -0.2 0.6 -0.2 -1.2 -0.7 -0.7 -0.6 -0.5 -0.6
Hair Pigment 0.0 0.1 0.6 0.4 0.2 -0.2 -0.8 0.3 -0.2 0.3 0.1 0.1 0.2
Tanning 0.2 2.3 5.3 2.3 -0.2 1.6 0.0 -0.3 -1.8 -1.7 -1.7 -1.9 -1.5
Hand grip strength (left) 0.5 1.4 11.3 -0.9 -0.8 -0.6 -3.4 0.9 0.1 0.2 -0.0 -0.2 0.4
Number of treatments/medications taken 0.4 0.7 4.5 -0.3 -0.4 -0.3 2.1 -0.8 0.4 0.5 0.7 0.5 0.3
Average weekly spirits intake 0.4 0.5 1.9 -0.1 0.1 -0.8 -1.4 -1.3 0.3 0.3 0.3 0.2 0.6
Sensitivity / hurt feelings 0.2 0.3 0.9 -0.9 -0.2 0.2 0.1 0.4 0.7 0.7 0.7 0.9 -0.1
Frequency of depressed mood in last 2 weeks 0.2 0.2 0.6 -0.4 -0.2 0.8 -0.1 0.2 0.5 0.5 0.5 0.7 -0.7
Hearing difficulty/problems: Yes 1.4 2.1 3.6 1.7 0.5 1.5 -1.2 -1.4 -1.5 -1.5 -1.4 -1.9 -1.4
Relative age of first facial hair 2.4 4.9 7.8 -2.4 -0.7 -2.8 -2.4 2.1 2.1 2.0 2.2 2.2 2.6
Other serious medical condition/disability diagnosed by doctor 0.5 0.6 1.1 0.6 -0.7 0.5 1.1 -0.7 -0.9 -0.9 -0.8 -0.8 -0.7
Ever used hormone-replacement therapy (HRT) 0.2 0.3 1.6 0.1 -0.2 -0.0 0.8 -1.3 -0.0 0.0 0.0 -0.6 0.1
Ever had hysterectomy (womb removed) 0.4 0.4 3.7 -0.5 -0.5 -0.3 1.9 0.2 0.1 0.1 0.1 0.0 -0.0
Systolic blood pressure, automated reading 0.6 1.8 10.6 0.9 2.3 0.6 3.3 -0.1 -0.3 -0.3 -0.2 -0.2 -0.4
Eye problems/disorders: Diabetes related eye disease 0.4 0.5 1.0 0.6 -0.1 0.6 0.2 1.0 -0.8 -0.8 -0.7 -0.7 -0.5
Angina 0.7 0.9 3.4 0.6 -1.0 1.1 1.9 -0.5 -0.6 -0.6 -0.5 -0.5 -1.1
Medication for hormone replacement therapy 0.8 0.9 1.8 -0.7 -0.4 -0.6 -0.6 -0.8 1.3 1.3 1.3 1.3 0.5
Vitamin and mineral supplements 0.3 0.4 0.7 -0.3 -0.6 0.9 0.2 -0.8 -0.5 -0.7 -0.8 -0.5 -0.8
Supplements: Zinc 2.9 3.2 6.3 -2.0 0.5 -2.5 -0.7 -0.7 1.9 2.2 2.0 1.6 2.4
Medication: Co-codamol 0.6 0.7 6.1 0.5 2.5 0.1 0.4 0.3 0.1 0.0 0.1 0.5 0.0
Medication: Metformin 0.1 0.2 0.8 -0.6 -0.0 -0.2 0.5 -0.9 0.1 0.1 0.4 -0.1 0.0
Diabetes (father) 0.4 0.5 3.1 0.4 0.4 0.1 1.0 1.8 -0.4 -0.5 -0.5 -0.0 -0.4
Diabetes (mother) 0.2 0.2 1.2 -0.2 -0.5 0.2 0.3 -1.1 -0.3 -0.2 -0.3 -0.4 0.0
Severe depression (siblings) 0.5 0.6 2.0 -0.4 1.4 0.3 -0.6 -0.6 0.8 0.8 0.7 0.8 -0.4
Pack years adult smoking proportion 1.2 1.8 3.8 -1.0 -1.8 -0.7 0.1 1.6 1.6 1.4 1.4 1.9 0.8
Impedance of leg (right) 0.3 1.2 2.9 -0.9 0.3 -0.1 -0.7 1.7 1.4 1.3 1.2 1.6 0.3
Leg fat-free mass (left) 0.9 4.5 7.0 -2.6 -2.1 -2.3 1.2 -0.9 2.4 2.3 2.4 2.0 2.4
Trunk fat percentage 1.3 5.0 7.2 -2.5 -0.4 -2.7 1.6 -0.0 2.6 2.6 2.6 2.5 2.7
Hand grip strength (right) 0.5 1.3 10.9 -0.1 -1.2 -0.4 -3.3 0.1 -0.1 -0.0 -0.2 -0.4 0.3
Townsend deprivation index at recruitment 0.2 0.3 1.7 -0.1 0.2 0.0 -0.6 1.3 0.5 0.4 0.1 1.0 -0.3
Current tobacco smoking 0.2 0.3 2.5 0.3 0.5 -0.2 -0.3 1.6 0.2 0.1 -0.0 0.7 -0.0
Average weekly fortified wine intake 0.2 0.2 1.1 0.7 0.2 -0.0 -1.0 0.3 -0.1 -0.0 -0.1 -0.0 -0.0
Maternal smoking around birth 0.6 0.8 3.0 0.6 -0.2 1.7 0.5 -0.8 -0.6 -0.6 -0.7 -0.6 -1.6
Fed-up feelings 0.2 0.3 1.3 -0.4 0.3 -0.1 1.2 1.0 0.2 0.1 0.2 0.4 0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.5 0.8 -0.6 0.9 0.4 -0.8 0.4 0.8 0.8 0.7 0.9 -0.4
Relative age voice broke 1.2 1.9 4.2 -1.5 -1.1 -2.1 -1.1 1.2 1.2 1.1 1.2 1.1 1.8
Taking other prescription medications 0.3 0.4 1.3 -0.2 0.6 0.4 0.6 -1.1 0.6 0.6 0.7 0.7 -0.4
Age when periods started (menarche) 0.2 0.5 3.3 -0.2 1.8 0.6 -0.2 0.9 -0.1 -0.1 -0.2 0.1 -0.7
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 2.5 -0.5 -1.6 -0.7 0.9 0.6 0.1 0.1 0.1 0.2 0.4
Heel bone mineral density (BMD) T-score, automated (left) 1.4 3.2 7.1 -2.7 -0.4 -2.3 0.7 0.1 1.9 1.8 1.9 1.8 2.2
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.5 -0.2 -0.1 -0.6 -0.5 -0.4 -0.1 0.1 0.0 -0.2 0.7
Qualifications: CSEs or equivalent 2.6 3.4 6.5 -1.4 -1.6 -2.2 -0.4 0.8 2.3 2.2 2.2 2.5 1.8
Serious illness, injury or assault to yourself 0.4 0.5 2.8 -0.5 -0.2 0.6 0.6 -1.7 0.2 0.4 0.4 0.4 -0.8
High blood pressure 1.1 3.0 26.2 0.6 -0.0 0.5 5.1 -1.3 -0.6 -0.7 -0.4 -0.9 -0.2
Hayfever, allergic rhinitis or eczema 0.9 2.0 8.5 0.5 2.6 0.8 -2.9 -1.2 -0.5 -0.5 -0.5 -0.7 -0.8
Multivitamins +/- minerals 1.1 1.4 2.4 -0.8 -0.7 -1.5 -0.2 0.6 1.4 1.5 1.6 1.3 1.3
Stomach or abdominal pain in last month 0.6 0.8 2.2 1.5 -0.7 1.2 -0.2 0.1 -0.8 -0.8 -0.7 -0.5 -1.3
Supplements: Glucosamine 0.1 0.1 1.1 -0.2 -0.3 0.2 -0.1 -1.0 0.0 0.0 0.2 -0.1 -0.0
Diverticular disease/diverticulitis (self-reported) 0.9 1.0 5.8 -0.9 -2.4 0.5 1.8 -0.2 -0.0 -0.1 0.1 0.1 -0.2
Medication: Atenolol 0.7 0.9 2.3 -0.3 -1.5 -0.8 0.7 -1.0 0.8 0.8 0.9 1.1 0.8
Medication: Levothyroxine sodium 0.2 0.3 0.9 -0.8 -0.1 -0.6 0.9 -0.0 0.6 0.6 0.5 0.6 0.5
Sitting height 0.9 6.4 15.0 -3.9 -1.6 -2.0 0.2 0.6 3.1 3.1 3.1 2.7 2.3
Chronic bronchitis/emphysema (father) 0.3 0.4 0.8 0.5 0.8 -0.1 0.9 -0.6 -0.7 -0.7 -0.8 -0.7 -0.1
High blood pressure (mother) 0.9 1.3 5.0 -0.8 -1.4 -1.6 0.2 -2.2 0.5 0.5 0.7 0.1 1.4
Body mass index (BMI) 0.8 3.5 5.2 -2.2 -0.9 -2.3 2.1 -0.7 1.8 1.8 2.0 1.8 2.3
Impedance of leg (left) 0.3 1.2 2.3 -1.1 0.1 -0.1 -1.3 1.5 1.4 1.3 1.2 1.5 0.3
Leg predicted mass (left) 0.8 4.4 6.8 -2.6 -2.1 -2.3 1.3 -0.9 2.3 2.3 2.3 2.0 2.3
Trunk fat mass 1.6 7.1 10.4 -3.2 -1.1 -3.0 1.9 -0.3 3.1 3.0 3.1 2.9 3.1
Waist circumference 1.0 3.8 6.2 -2.5 -1.0 -1.9 1.8 -1.2 2.2 2.2 2.3 1.9 2.1
Number of incorrect matches in round 0.3 0.5 1.7 0.1 -0.1 -1.3 0.6 0.0 0.5 0.6 0.5 0.5 1.2
Past tobacco smoking 0.2 0.3 1.7 0.2 1.3 0.7 0.4 -0.3 0.0 -0.0 -0.1 0.3 -0.6
Alcohol usually taken with meals 0.1 0.2 0.7 0.2 -0.4 0.8 -0.1 0.1 -0.4 -0.4 -0.2 -0.6 -0.7
Nervous feelings 0.2 0.3 1.6 -0.1 -1.3 -0.2 1.1 0.4 0.0 0.0 0.0 0.1 0.3
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 2.0 -0.1 -0.9 -0.1 -1.4 0.3 0.8 0.8 0.7 0.9 0.1
Hearing difficulty/problems with background noise 0.8 1.3 2.3 1.2 0.5 1.1 -1.1 -0.7 -1.3 -1.3 -1.2 -1.5 -1.1
Hair/balding pattern: Pattern 2 1.5 1.8 2.9 -1.6 -0.7 -1.2 -1.3 0.1 1.7 1.7 1.6 1.6 1.2
Had menopause 5.0 6.3 12.1 2.8 2.7 1.7 -0.8 -0.3 -3.1 -3.1 -3.1 -3.5 -1.7
Had other major operations 0.3 0.4 2.2 -0.4 0.8 0.3 -0.4 -1.5 0.3 0.3 0.4 0.3 -0.1
Forced vital capacity (FVC) 0.3 1.2 4.9 -0.7 -0.8 -0.8 -2.2 1.0 1.0 1.1 0.9 1.0 0.8
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.7 4.1 -2.0 0.4 -2.0 -0.0 0.3 1.3 1.2 1.3 1.2 1.7
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 1.4 0.4 1.2 0.6 0.9 0.7 -0.3 -0.3 -0.4 -0.2 -0.6
Qualifications: None of the above 0.6 1.2 7.9 -0.8 0.6 -0.4 2.8 1.7 0.1 -0.1 0.2 0.4 0.1
Financial difficulties in last 2 years 0.8 1.0 4.0 0.2 -0.9 -0.6 -1.7 2.0 0.7 0.6 0.6 0.9 0.5
Mouth/teeth dental problems 2.1 3.2 6.2 -2.5 -0.7 -1.8 -1.2 1.0 2.0 2.0 1.9 2.3 1.8
Heart attack 1.7 2.2 4.3 -1.8 -1.8 -0.6 -0.8 0.6 1.8 1.7 1.8 2.1 0.8
Allergy 0.5 1.2 4.0 0.6 -1.9 0.5 2.0 0.6 -0.9 -0.9 -0.9 -0.6 -0.5
Pain all over the body in last month 0.3 0.4 1.9 -0.1 -0.6 -0.6 1.4 0.6 -0.0 -0.2 -0.0 0.1 0.7
Diabetes (self-reported) 0.2 0.3 2.6 0.4 -0.4 -0.3 1.6 0.1 -0.0 0.0 -0.0 -0.1 0.3
Hayfever/allergic rhinitis (self-reported) 0.6 0.8 3.1 -0.2 1.8 -0.4 -1.3 -1.4 0.4 0.5 0.5 0.1 0.7
Medication: Ramipril 0.4 0.5 2.5 -0.5 -1.2 0.2 0.1 -1.6 0.1 0.1 0.2 -0.0 -0.3
Medication: Simvastatin 0.5 0.8 2.2 -1.1 -0.5 -1.4 1.5 0.1 0.4 0.5 0.5 0.5 1.1
Fluid intelligence score 0.2 0.4 3.0 0.0 0.2 -0.6 -0.7 1.7 0.1 0.2 -0.0 0.3 0.5
Illnesses of siblings 0.1 0.2 0.7 0.4 -0.0 0.8 -0.4 0.4 -0.2 -0.2 -0.3 -0.2 -0.6
Neuroticism score 0.4 0.8 2.6 -0.7 -1.6 0.3 1.0 0.5 0.9 0.8 0.8 1.1 -0.0
Weight 1.0 5.1 8.9 -3.0 -1.7 -2.4 1.7 -0.9 2.5 2.4 2.6 2.1 2.6
Impedance of arm (right) 0.2 1.0 4.3 2.1 1.1 0.8 -0.8 0.7 -0.7 -0.8 -0.9 -0.6 -0.7
Arm fat percentage (right) 0.6 2.3 3.8 -1.4 -0.4 -1.9 1.9 -0.5 1.6 1.5 1.6 1.6 1.9
Trunk fat-free mass 0.8 4.4 9.1 -3.0 -2.6 -1.9 1.4 -0.6 2.2 2.2 2.2 1.8 2.0
Hip circumference 0.5 2.3 4.5 -1.6 -1.2 -2.1 1.3 -0.2 1.5 1.5 1.6 1.2 2.1
Time employed in main current job 2.5 2.9 9.5 3.1 1.5 0.9 0.5 -0.3 -2.0 -2.0 -1.8 -2.1 -1.0
Alcohol intake versus 10 years previously 1.2 1.9 4.0 1.8 1.8 0.3 0.8 0.1 -1.6 -1.5 -1.5 -2.0 -0.5
Father’s age at death 2.2 3.0 4.8 2.2 1.8 1.1 -1.4 1.0 -2.1 -2.1 -2.1 -1.6 -1.4
Worrier / anxious feelings 0.2 0.4 1.7 0.3 -1.1 0.1 1.3 0.5 0.4 0.4 0.5 0.6 0.0
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.2 0.9 -0.1 -0.9 0.4 0.2 -0.3 0.2 0.2 0.1 0.2 -0.6
Falls in the last year 0.3 0.4 2.6 -0.3 -1.6 0.1 1.3 0.1 -0.2 -0.1 -0.1 -0.1 0.2
Hair/balding pattern: Pattern 3 0.2 0.4 2.2 0.4 0.1 -0.4 0.5 1.5 -0.5 -0.6 -0.4 -0.1 0.3
Number of live births 0.5 0.7 3.1 -0.7 0.6 0.3 0.5 1.8 0.7 0.8 0.8 0.7 -0.2
Forced expiratory volume in 1-second (FEV1) 0.4 1.2 5.5 -0.7 -0.8 -0.8 -2.3 0.8 1.0 1.1 0.8 1.0 0.8
Pulse rate 0.2 0.4 2.7 0.0 -0.1 0.1 -1.6 -0.3 0.5 0.5 0.5 0.6 -0.1
Happiness 0.4 0.5 1.2 1.1 0.1 0.7 0.6 0.3 -0.8 -0.8 -0.7 -0.9 -0.3
Noisy workplace 0.4 0.5 1.3 0.2 0.9 -1.1 0.4 0.3 -0.4 -0.4 -0.3 -0.7 1.1
Qualifications: A levels/AS levels or equivalent 0.3 0.7 2.8 -0.8 -0.1 -0.7 -1.7 -0.1 0.8 0.8 0.7 0.6 0.9
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.3 1.4 0.4 0.1 -0.4 -1.0 -1.2 0.0 0.1 0.2 -0.2 0.4
Mouth/teeth dental problems: Dentures 0.6 1.1 2.0 1.2 1.3 0.1 1.4 1.0 -1.1 -1.1 -1.0 -1.1 -0.2
Asthma 0.4 0.9 2.9 0.4 1.7 0.9 -0.1 -1.7 -0.3 -0.2 -0.3 -0.7 -1.1
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.7 1.9 0.4 1.4 -1.4 0.2 0.8 0.2 0.3 0.4 0.0 1.3
Medication: Cholesterol lowering 0.6 1.0 3.8 -0.9 -0.3 -0.7 2.0 1.1 0.8 0.8 0.9 1.0 0.6
Depression (self-reported) 0.4 0.5 1.2 -1.1 -0.3 0.2 0.8 -1.0 0.7 0.7 0.7 0.4 -0.2
Medication: Lansoprazole 0.3 0.4 1.3 -0.7 -1.1 0.1 0.3 -1.0 0.4 0.4 0.4 0.1 -0.1
Prospective memory result 0.6 0.8 4.1 0.9 1.0 -0.1 2.0 0.3 -0.6 -0.7 -0.7 -0.5 0.1
Lung cancer (father) 0.2 0.2 0.4 0.4 0.5 -0.2 0.5 -0.1 -0.5 -0.4 -0.5 -0.7 -0.1
Illnesses of mother 0.5 0.6 4.0 0.6 0.4 0.7 -2.0 0.6 0.2 0.2 0.1 0.5 -0.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.1 4.8 -0.9 -1.0 -0.8 -2.2 0.5 0.9 1.0 0.7 0.9 0.8
Pulse wave Arterial Stiffness index 0.4 0.5 0.7 -0.6 -0.8 -0.6 -0.4 0.6 0.7 0.8 0.8 0.8 0.7
Impedance of arm (left) 0.4 1.8 5.9 2.4 1.6 0.9 -1.3 0.5 -1.2 -1.2 -1.3 -1.2 -1.0
Arm fat mass (right) 1.1 4.3 6.8 -2.4 -0.8 -2.6 1.9 -0.7 2.2 2.2 2.3 2.1 2.6
Trunk predicted mass 0.8 4.3 9.1 -3.0 -2.6 -1.9 1.4 -0.5 2.1 2.2 2.2 1.8 2.1
Standing height 0.2 2.2 5.2 -2.3 -2.0 -0.8 -0.3 -0.5 1.8 1.8 1.8 1.0 1.2
Length of working week for main job 0.9 1.0 2.6 0.6 0.3 1.0 0.8 -0.7 -1.2 -1.0 -1.2 -1.6 -0.9
Exposure to tobacco smoke at home 0.7 0.8 2.5 -1.6 -0.8 -0.2 -0.1 0.7 1.1 1.0 1.1 0.8 -0.0
Breastfed as a baby 2.0 2.5 4.3 1.0 0.8 2.0 -0.5 -0.1 -1.9 -1.9 -2.0 -1.9 -2.1
Tense / ‘highly strung’ 0.5 0.8 4.1 0.0 -2.0 -0.1 -0.2 0.3 0.9 0.8 0.9 1.1 0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.8 1.2 2.3 -0.8 -1.4 -0.7 1.5 -0.5 1.2 1.1 1.4 1.1 0.6
Hair/balding pattern: Pattern 4 0.2 0.6 0.9 -0.8 -0.7 -1.0 0.1 0.4 0.9 0.9 0.8 0.7 0.9
Birth weight of first child 0.1 0.2 1.0 0.6 1.0 -0.0 0.3 0.7 -0.3 -0.3 -0.2 -0.1 -0.1
Peak expiratory flow (PEF) 0.8 1.8 3.9 -1.4 -2.0 -0.9 -1.4 -0.3 1.5 1.6 1.4 1.1 1.0
Pulse wave reflection index 0.5 0.6 1.2 -0.6 -0.2 -1.1 -0.3 1.0 0.6 0.6 0.7 0.7 1.1
Ever highly irritable/argumentative for 2 days 0.2 0.3 0.8 0.9 0.7 0.5 0.5 0.8 -0.1 -0.1 0.1 0.1 -0.2
Loud music exposure frequency 1.9 2.1 3.2 -1.7 -0.6 -1.6 -0.2 0.3 1.8 1.7 1.8 1.4 1.8
Qualifications: O levels/GCSEs or equivalent 1.1 1.7 5.5 -1.2 -1.5 0.2 -2.3 -0.4 1.5 1.5 1.4 1.3 0.1
Mouth/teeth dental problems: Bleeding gums 1.5 1.9 2.9 1.3 -0.9 1.5 -1.2 -1.7 -1.4 -1.4 -1.4 -1.5 -1.5
Blood clot in the leg (DVT) 1.4 1.7 2.7 -1.2 -0.1 -1.6 0.3 1.1 1.6 1.6 1.6 1.5 1.5
Medication: Paracetamol 0.5 0.8 4.9 -0.3 -1.0 -0.3 2.2 0.6 0.6 0.5 0.6 0.5 0.3
Headache pain in last month 0.0 0.1 0.2 0.1 -0.0 -0.2 0.2 0.1 0.3 0.4 0.4 0.5 0.1
Medication for cholesterol, blood pressure or diabetes 0.9 1.4 8.8 1.3 0.6 0.5 -3.0 -0.4 -0.8 -0.7 -0.9 -0.8 -0.4
Glaucoma (self-reported) 2.7 3.1 5.7 -2.3 -1.5 -1.2 0.5 0.0 2.3 2.2 2.2 2.4 1.3
Gout (self-reported) 1.0 1.4 2.2 -1.0 1.4 -1.4 1.2 0.9 1.1 1.1 1.2 1.0 1.5
Hypothyroidism/myxoedema (self-reported) 0.5 1.0 1.9 -1.4 -0.5 -1.1 0.6 1.1 1.0 1.0 0.9 1.0 1.2
Medication: Amlodipine 0.7 1.0 4.7 0.1 1.3 0.8 2.2 -1.6 -0.1 -0.1 -0.0 -0.3 -0.6
Medication: Ventolin 100micrograms inhaler 1.1 1.4 2.0 1.1 0.5 1.2 1.2 -0.3 -1.4 -1.3 -1.4 -1.4 -1.4
Birth weight 1.6 3.4 5.7 -1.8 -2.1 -1.4 0.3 -0.9 2.4 2.3 2.4 2.2 1.5
Chronic bronchitis/emphysema (mother) 0.5 0.5 2.0 -0.2 1.4 -0.4 0.6 -1.2 -0.5 -0.5 -0.4 -0.8 0.3
High blood pressure (siblings) 0.3 0.4 1.3 0.2 -1.1 -0.9 0.7 -0.8 -0.4 -0.5 -0.3 -0.4 0.6
Forced vital capacity (FVC), Best measure 0.1 0.5 2.1 -0.5 -0.7 -0.4 -1.4 0.6 0.7 0.7 0.5 0.6 0.4
Body fat percentage 1.2 4.9 6.8 -2.5 -0.6 -2.6 1.6 -0.1 2.6 2.5 2.5 2.6 2.6
Leg fat percentage (right) 1.8 6.7 9.9 -3.1 -1.1 -2.7 1.9 -0.1 3.0 3.0 3.0 3.1 2.8
Arm fat-free mass (right) 1.1 5.8 12.8 -3.6 -2.5 -2.3 1.0 -0.7 2.7 2.7 2.7 2.2 2.4
Exposure to tobacco smoke outside home 0.5 0.7 2.6 -1.3 -0.7 0.1 -1.6 -0.9 0.5 0.5 0.7 0.5 -0.5
Comparative body size at age 10 0.1 0.3 0.9 0.4 -0.1 -0.3 1.0 0.6 -0.7 -0.7 -0.7 -0.6 0.3
Number of full brothers 0.4 0.5 2.5 -1.0 -1.6 0.5 -0.5 0.6 0.2 0.2 0.2 0.3 -0.6
Worry too long after embarrassment 0.3 0.5 2.2 0.3 -0.1 1.5 -0.2 -0.0 -0.5 -0.5 -0.7 -0.4 -1.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.6 4.0 0.4 -0.0 -0.3 2.0 1.1 -0.1 -0.2 0.0 -0.0 0.5
Wheeze or whistling in the chest in last year 0.7 1.3 2.3 1.5 0.8 1.3 0.6 0.0 -1.2 -1.2 -1.2 -0.9 -1.5
Number of children fathered 0.6 0.7 3.6 -0.0 -1.0 0.3 1.9 -0.9 -0.5 -0.4 -0.5 -0.8 -0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 1.1 -0.2 -0.5 -0.6 -0.4 1.0 0.1 0.0 0.1 0.2 0.5
Age at first live birth 0.4 0.6 1.6 -0.6 -0.5 -0.3 -1.2 0.8 0.8 0.8 0.7 1.2 0.4
Pulse wave peak to peak time 0.3 0.3 0.6 0.5 0.5 0.4 0.3 -0.5 -0.6 -0.7 -0.7 -0.8 -0.5
Health satisfaction 1.2 1.5 4.0 1.4 -0.4 2.0 0.4 -0.7 -1.1 -1.1 -1.2 -0.9 -2.0
Shortness of breath walking on level ground 0.2 0.3 0.9 0.6 -0.9 0.5 0.7 0.2 0.0 -0.1 -0.0 0.3 -0.8
Qualifications: College or University degree 0.3 1.1 2.4 1.2 0.0 1.1 -1.6 0.6 -1.1 -1.0 -1.0 -1.2 -0.8
Eye problems/disorders: None of the above 0.5 0.5 2.5 -0.6 0.5 -0.7 -1.6 -0.4 0.6 0.6 0.6 0.2 0.6
Mouth/teeth dental problems: Loose teeth 0.1 0.1 0.6 0.1 -0.7 -0.2 0.4 -0.8 0.0 -0.0 0.1 -0.3 0.3
Emphysema/chronic bronchitis 0.2 0.2 1.1 0.0 -0.6 -1.0 0.1 0.4 -0.0 0.1 -0.1 -0.2 0.9
Medication for pain relief, constipation, heartburn 0.1 0.2 0.7 -0.5 0.3 0.6 -0.8 -0.2 -0.1 -0.1 -0.4 -0.1 -0.4
Neck or shoulder pain in last month 1.1 1.5 2.4 1.5 -0.5 1.5 -0.4 -1.1 -1.4 -1.2 -1.2 -1.3 -1.5
Medication: Blood pressure 1.1 2.0 11.9 -1.4 -1.7 -0.3 3.5 -0.8 0.7 0.7 1.0 0.4 0.6
Angina (self-reported) 0.7 0.9 3.4 0.7 -0.8 1.2 1.9 -0.3 -0.7 -0.7 -0.6 -0.5 -1.2
Migraine (self-reported) 0.3 0.4 1.3 -0.5 -0.3 -0.2 0.4 -1.2 0.7 0.8 0.9 0.5 0.4
Medication: Ibuprofen 0.4 0.5 2.0 0.6 1.4 -0.9 0.2 0.7 -0.0 0.0 0.2 -0.2 0.9
Medication: Allopurinol 0.8 1.1 5.1 -0.4 2.3 -1.1 0.8 0.9 0.7 0.7 0.7 0.6 1.1
Medication: Omeprazole 0.7 0.9 7.7 -0.2 -2.8 0.2 -0.3 -0.4 0.3 0.3 0.4 0.5 -0.3
Medication: Seretide 50 evohaler 0.1 0.1 0.3 0.1 0.6 -0.2 0.2 0.2 0.1 0.1 0.2 -0.1 0.3
Mean time to correctly identify matches 0.7 1.2 1.8 1.3 -0.7 1.0 -0.7 -1.2 -1.3 -1.3 -1.2 -1.3 -0.9
Heart disease (mother) 1.1 1.4 4.3 -1.4 -0.4 -1.3 2.1 -0.9 0.8 0.9 0.9 0.5 1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.2 0.5 0.5 0.4 0.3 0.2 0.7 -0.4 -0.5 -0.3 -0.1 -0.4
Whole body fat mass 1.5 6.3 9.2 -3.0 -1.2 -2.9 1.6 -0.5 2.9 2.8 2.9 2.7 3.0
Leg fat mass (right) 2.2 8.5 12.9 -3.6 -1.7 -3.1 1.9 -0.5 3.4 3.3 3.4 3.3 3.2
Arm predicted mass (right) 1.3 6.5 14.4 -3.8 -2.7 -2.4 1.0 -0.6 2.8 2.8 2.9 2.4 2.6
Pulse rate, automated reading 0.3 0.9 3.1 -0.3 -1.8 -0.7 -1.2 -0.4 1.0 0.9 0.9 1.0 0.6
Alcohol intake frequency. 1.8 4.1 6.8 2.6 1.9 2.1 1.9 0.3 -2.1 -2.2 -2.1 -2.1 -2.0
Comparative height size at age 10 0.5 2.5 8.1 -1.9 -2.8 -1.1 0.6 0.1 1.6 1.7 1.8 1.3 1.2
Number of full sisters 0.2 0.2 0.8 -0.7 -0.1 -0.2 -0.2 -0.9 0.4 0.4 0.3 0.3 0.1
Suffer from ‘nerves’ 0.6 0.9 2.3 -0.8 -1.5 -0.6 1.1 1.0 0.9 0.8 0.7 1.0 0.9
Overall health rating 0.5 1.1 1.8 -1.0 -1.0 -0.8 1.4 -0.2 1.1 1.2 1.2 1.1 0.9
Chest pain or discomfort 0.2 0.3 0.5 -0.5 -0.5 -0.1 -0.1 -0.6 0.7 0.7 0.7 0.6 0.1
Had major operations 0.6 0.8 2.2 -0.4 0.2 -1.0 1.5 1.2 0.7 0.7 0.7 0.7 0.9
Age at last live birth 1.1 1.7 3.2 -1.1 0.0 -1.0 -1.7 1.1 1.4 1.3 1.5 1.8 1.1
Family relationship satisfaction 0.4 0.5 1.6 1.2 0.6 0.8 -0.8 0.7 -0.5 -0.6 -0.5 -0.3 -0.7
Leg pain on walking 0.8 1.0 3.0 1.1 0.4 1.7 0.7 1.5 -0.3 -0.3 -0.4 0.1 -1.7
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.4 2.0 0.1 -0.2 -0.4 -1.4 -1.1 0.1 0.1 0.0 0.2 0.3
Commuting to job workplace: Car/motor vehicle 0.4 0.5 2.3 -0.1 -1.4 0.3 1.5 0.2 -0.3 -0.3 -0.3 -0.2 -0.1
Illness, injury, bereavement, stress in last 2 years 0.2 0.2 0.8 0.4 0.6 -0.3 0.9 0.1 -0.4 -0.5 -0.5 -0.6 0.3
Medication: Aspirin 0.1 0.2 1.1 0.1 -0.7 0.1 1.0 -0.1 0.0 -0.0 0.2 0.3 -0.1
Supplements: Vitamin C 0.1 0.2 1.3 0.2 1.2 -0.2 -0.4 0.4 -0.1 -0.0 0.0 0.2 0.1
Knee pain experienced in last month 0.6 0.9 2.4 0.8 0.2 1.1 -0.4 -1.6 -0.9 -0.9 -0.8 -0.6 -1.3
Hypertension (Self-reported) 1.2 3.2 24.1 0.7 -0.2 0.9 4.9 -1.4 -1.0 -1.0 -0.8 -1.3 -0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 1.6 0.6 -1.0 0.6 -1.3 -0.3 -0.7 -0.8 -0.7 -0.8 -0.8
Illnesses of father: Heart disease 0.5 0.7 1.7 -0.5 0.1 -0.2 0.9 0.2 1.2 1.2 1.2 1.3 0.2
Illnesses of siblings: Diabetes 0.3 0.3 1.2 -0.2 1.1 -0.2 -0.3 1.1 0.3 0.3 0.4 0.4 0.2
Smoking status: Previous 0.2 0.3 1.3 -0.5 -1.2 -0.9 0.1 0.2 0.2 0.2 0.3 -0.1 0.8
Forced expiratory volume in 1-second (FEV1), predicted 0.8 1.8 4.2 -2.0 -1.1 -1.1 -0.0 0.6 1.6 1.6 1.4 1.4 1.3
Whole body fat-free mass 0.8 4.8 9.1 -3.0 -2.5 -2.2 1.3 -0.7 2.3 2.3 2.4 1.9 2.3
Leg fat-free mass (right) 0.6 3.4 5.7 -2.4 -2.1 -2.0 1.0 -1.1 1.9 2.0 2.0 1.6 2.0
Arm fat percentage (left) 0.5 2.1 3.6 -1.3 -0.4 -1.9 1.8 -0.7 1.5 1.4 1.5 1.5 1.9
Average weekly red wine intake 0.7 1.0 4.4 0.1 -2.1 -0.3 -1.8 1.3 0.1 0.1 0.0 0.2 0.3
Handedness (chirality/laterality): Left-handed 0.5 0.6 2.6 0.2 1.6 0.2 0.9 0.1 0.7 0.6 0.4 1.0 -0.2
Mood swings 0.1 0.1 0.3 -0.1 -0.4 0.5 0.4 0.5 0.0 -0.1 -0.1 0.1 -0.5
Loneliness, isolation 0.3 0.4 1.3 -0.1 -1.0 1.2 -0.2 -0.2 0.1 0.0 0.0 0.2 -1.0
Long-standing illness, disability or infirmity 0.9 1.3 3.2 0.7 -0.2 1.7 1.8 -0.8 -0.9 -1.0 -0.8 -1.0 -1.6
Ever had bowel cancer screening 4.4 5.2 6.5 2.2 2.2 2.5 1.9 -2.2 -2.2 -2.2 -2.2 -2.5 -2.5
Diabetes diagnosed by doctor 0.2 0.3 2.3 -0.1 -0.8 -0.4 1.5 -0.3 0.2 0.2 0.3 0.1 0.3
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 1.0 -1.0 -1.0 -0.6 -0.3 -0.1 0.2 0.2 0.2 -0.0 0.4
Friendships satisfaction 0.5 0.6 1.3 1.1 0.7 0.8 0.3 1.1 -0.8 -0.8 -0.6 -0.6 -0.9
Qualifications: nursing, teaching 0.1 0.1 0.8 0.2 -0.4 0.0 -0.9 0.5 -0.1 -0.0 -0.1 -0.2 0.1
Commuting to job workplace: Walk 0.6 0.6 4.2 0.4 0.3 0.6 -2.0 -0.1 -0.6 -0.6 -0.4 -0.6 -0.5
Eye problems/disorders: Cataract 0.5 0.5 3.1 0.9 -0.5 0.5 1.8 0.0 -0.4 -0.4 -0.4 -0.2 -0.5
Mouth/teeth dental problems: Mouth ulcers 1.0 1.6 4.9 0.8 0.7 2.2 1.9 0.5 -0.8 -0.8 -0.7 -0.8 -1.9
Medication for cholesterol 0.6 0.9 7.1 0.2 0.5 0.1 -1.3 2.7 0.1 0.1 -0.0 0.3 -0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.3 0.7 -0.8 -0.8 0.6 0.4 -0.1 0.5 0.3 0.5 0.6 -0.5
Back pain experienced in last month 0.4 0.5 2.1 0.6 -0.8 -0.1 -1.5 -1.4 0.2 0.3 0.3 -0.1 0.1
Mineral and other dietary supplements 0.3 0.3 1.5 0.1 -0.8 0.1 0.9 1.2 -0.0 -0.2 -0.3 0.2 -0.3
Breast cancer (self-reported) 0.7 0.8 1.2 0.8 -0.9 1.1 0.9 -0.8 -0.9 -0.9 -0.8 -0.9 -1.1
Asthma (self-reported) 0.5 1.1 2.9 0.6 1.7 1.2 0.0 -1.7 -0.4 -0.3 -0.4 -0.9 -1.3
Osteoporosis (self-reported) 0.6 0.8 6.2 0.1 -0.5 0.8 -2.5 0.5 -0.2 -0.1 -0.1 -0.3 -0.7
Osteoarthritis (self-reported) 1.2 1.6 3.1 1.3 0.2 0.9 1.0 -0.6 -1.8 -1.8 -1.6 -1.6 -1.1
Medication: Aspirin 0.2 0.3 2.2 0.3 -0.5 0.1 1.5 0.1 -0.1 -0.1 0.0 0.2 -0.1
Medication: Gliclazide 0.5 0.6 1.2 -0.8 0.1 -0.7 -0.0 0.7 1.0 1.0 0.8 1.1 0.7
Illnesses of father: None of the above (group 1) 1.1 1.4 2.4 0.8 0.4 1.0 -1.1 0.4 -1.6 -1.5 -1.6 -1.5 -1.0
Smoking status: Current 0.1 0.2 1.9 0.3 0.1 -0.2 0.1 1.4 0.1 -0.0 -0.1 0.5 0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 1.4 1.1 -0.5 0.7 -0.7 0.3 -1.1 -1.0 -1.2 -0.9 -0.9
Whole body water mass 0.8 4.3 8.5 -2.9 -2.4 -2.0 1.4 -0.7 2.2 2.2 2.2 1.8 2.1
Leg predicted mass (right) 0.6 3.4 5.6 -2.4 -2.1 -2.0 1.1 -1.0 1.9 1.9 2.0 1.5 2.0
Arm fat mass (left) 0.8 3.3 5.1 -2.1 -0.9 -2.2 1.9 -1.0 1.9 1.8 2.0 1.7 2.3
Number of self-reported non-cancer illnesses 0.9 1.6 3.2 1.3 1.4 0.8 1.7 -1.8 -1.1 -1.1 -0.8 -1.4 -0.8
Average weekly champagne plus white wine intake 1.8 2.4 3.2 -1.8 -0.4 -1.7 -1.6 0.9 1.8 1.7 1.8 1.6 1.7
Miserableness 0.4 0.6 1.4 -0.4 -0.8 -0.3 1.2 0.6 0.9 0.8 1.0 1.0 0.2
Guilty feelings 1.2 1.8 3.2 1.1 0.7 1.8 0.9 -0.1 -1.5 -1.5 -1.6 -1.3 -1.8
Wears glasses or contact lenses 1.6 1.8 3.5 1.5 1.9 1.0 0.2 -1.2 -1.5 -1.4 -1.4 -1.8 -0.7
Ever taken oral contraceptive pill 0.6 0.6 1.6 -0.8 -0.1 -0.9 -0.4 1.3 0.8 0.9 0.7 1.0 0.6
Hearing aid user 0.2 0.2 0.9 -0.6 -0.6 0.0 -0.2 -1.0 0.2 0.1 0.3 0.2 0.0
Mother’s age at death 0.5 0.6 2.7 -0.7 1.5 0.4 -1.7 -0.6 0.3 0.2 0.2 0.3 -0.2
Financial situation satisfaction 0.3 0.4 3.0 0.1 -0.5 -0.0 -1.7 0.5 0.3 0.3 0.1 0.5 -0.0
Tinnitus: Yes, now most or all of the time 0.4 0.4 1.5 0.9 -0.1 0.3 -1.2 0.8 -0.4 -0.4 -0.3 -0.6 -0.5
Commuting to job workplace: Public transport 0.2 0.2 1.0 -0.3 1.0 0.2 -0.0 -0.8 0.4 0.4 0.5 0.1 0.0
Eye problems/disorders: Glaucoma 3.5 4.1 6.0 -2.3 -2.4 -1.9 -0.2 -0.2 2.5 2.4 2.4 2.4 1.9
Medication: Blood pressure 1.3 2.4 6.0 1.2 0.1 1.1 2.5 -2.4 -1.5 -1.4 -1.4 -1.8 -0.9
Pain type(s) experienced in last month: Hip pain 0.2 0.3 1.7 0.6 1.3 -0.3 0.2 0.7 0.1 0.0 0.2 0.1 -0.0
Supplements: Fish oil (including cod liver oil) 0.3 0.4 2.0 0.4 1.4 0.4 -0.6 -0.4 -0.5 -0.4 -0.3 -0.6 -0.3
High cholesterol (Self-reported) 0.3 0.5 1.5 -0.6 -0.7 -0.9 1.2 0.3 0.6 0.5 0.6 0.6 0.9
Medication: Bendroflumethiazide 1.1 1.7 12.3 0.3 -0.1 1.3 3.5 0.0 -0.6 -0.7 -0.6 -0.8 -1.1
Medication: Paracetamol 0.5 0.8 3.5 -0.8 -1.2 -0.5 1.9 0.3 0.7 0.7 0.8 0.8 0.4
Medication: Lisinopril 0.4 0.6 2.1 -0.8 1.0 -0.6 1.4 0.0 -0.3 -0.3 -0.3 -0.9 0.8
Medication: Atorvastatin 1.6 2.0 3.7 -1.4 -0.9 -0.5 1.6 -0.6 1.8 1.8 1.9 1.7 0.8
Illnesses of father: High blood pressure 1.3 1.6 3.0 -1.2 -1.7 -1.4 -0.2 0.1 1.5 1.4 1.6 1.4 1.2
Alcohol drinker status: Never 0.7 0.8 3.1 1.0 -0.8 1.8 0.3 0.3 -0.4 -0.5 -0.4 -0.3 -1.6
Ever smoked 0.4 0.7 2.8 -0.6 -1.7 -0.6 -1.1 1.2 0.4 0.4 0.4 0.3 0.6
Basal metabolic rate 0.9 5.1 9.5 -3.1 -2.3 -2.3 1.4 -0.7 2.5 2.5 2.5 2.1 2.4
Leg fat percentage (left) 1.7 6.3 10.3 -3.2 -1.2 -2.6 1.6 -0.3 2.9 2.9 2.9 2.9 2.8
Arm fat-free mass (left) 0.9 4.4 10.2 -3.2 -2.3 -2.0 1.2 -0.7 2.2 2.2 2.2 1.8 2.2
Number of operations (self-reported) 0.6 0.9 2.0 -1.2 -0.7 -0.8 1.4 -0.4 0.9 0.8 0.9 0.9 0.9
Average weekly beer plus cider intake 2.4 3.4 7.8 -1.6 0.5 -2.8 0.0 0.4 2.1 2.1 2.1 2.1 2.4
Irritability 0.4 0.7 5.3 0.0 -2.3 0.6 0.8 0.4 -0.1 -0.2 -0.2 -0.0 -0.4
Risk taking 1.4 2.1 5.9 -0.9 -0.2 -1.1 -2.4 -0.3 1.7 1.6 1.7 1.6 1.3
Ever had prostate specific antigen (PSA) test 0.6 0.6 1.8 1.1 -1.3 -0.1 0.6 0.8 -0.8 -0.8 -1.0 -0.3 -0.1
Fractured/broken bones in last 5 years 0.3 0.3 2.1 -0.5 -1.4 -0.1 -1.0 0.3 0.2 0.2 0.1 0.1 0.2
Age started oral contraceptive pill 0.9 1.1 2.0 1.2 1.0 1.0 -0.7 -1.4 -1.0 -0.9 -0.9 -1.2 -1.0
Diastolic blood pressure, automated reading 0.3 0.8 1.7 -0.4 0.5 -1.2 -1.3 -0.2 0.9 0.8 0.9 1.1 1.0
Ever depressed for a whole week 0.3 0.4 1.1 1.1 0.7 0.6 -0.5 0.3 -0.6 -0.6 -0.5 -0.5 -0.6
Unable to work because of sickness or disability 2.6 3.4 5.6 -2.2 -0.2 -2.0 0.8 -0.3 2.3 2.2 2.4 2.1 2.0
Commuting to job workplace: Cycle 0.7 0.8 2.5 1.6 -0.0 0.4 -0.8 0.6 -1.0 -0.9 -1.1 -1.1 -0.2
Myopia 0.8 1.1 2.4 1.2 0.7 1.6 -0.4 0.3 -1.0 -0.9 -1.1 -1.1 -1.5
Vascular/heart problems diagnosed by doctor 1.0 2.8 24.1 -0.6 0.2 -0.5 -4.9 1.4 0.6 0.6 0.3 0.8 0.2
Cholesterol lowering medication 0.7 1.0 2.9 -0.5 -1.4 -1.0 1.7 -1.4 0.5 0.6 0.7 0.3 1.0
Medication: Omeprazole (e.g. Zanprol) 0.4 0.4 2.8 -0.1 -1.7 0.2 -0.9 -0.5 0.3 0.2 0.3 0.4 -0.4
Pain experienced in last month 0.4 0.7 1.6 -1.2 0.5 -0.6 0.9 1.2 0.9 0.8 0.5 0.8 0.7
Supplements: Calcium 0.7 0.7 1.1 0.7 1.0 0.6 -1.0 -0.5 -1.0 -1.0 -0.9 -1.0 -0.6
Basal cell carcinoma (self-reported) 2.5 2.9 5.3 1.9 1.1 2.3 0.6 0.2 -1.8 -1.9 -2.0 -1.6 -2.3
Heart attack/myocardial infarction (self-reported) 2.3 3.0 5.6 -2.0 -2.4 -0.9 -0.9 0.6 2.0 2.0 2.0 2.4 1.1
Deep venous thrombosis (DVT) (self-reported) 1.6 2.1 3.4 -1.4 -0.2 -1.6 0.3 1.0 1.8 1.9 1.8 1.7 1.6
Heart disease (siblings) 0.2 0.2 1.0 -0.7 0.2 -0.5 -0.5 -1.0 0.2 0.1 0.2 0.0 0.2
Alcohol drinker status: Previous 0.4 0.4 3.7 -0.1 0.4 0.2 1.9 0.6 -0.2 -0.1 0.0 -0.2 -0.2
Pack years of smoking 0.9 1.4 2.9 -0.7 -1.6 -0.5 0.2 1.5 1.3 1.2 1.2 1.7 0.6
Impedance of whole body 0.1 0.6 2.1 0.9 1.0 0.3 -1.5 1.2 -0.0 -0.0 -0.2 0.0 -0.3
Leg fat mass (left) 2.1 8.3 13.2 -3.6 -1.8 -3.1 1.6 -0.6 3.4 3.3 3.4 3.2 3.2
Arm predicted mass (left) 1.1 5.4 12.3 -3.5 -2.4 -2.2 1.4 -0.7 2.5 2.5 2.6 2.0 2.4