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chr8:8,092,025-13,120,332

Best TWAS P=3.6e-10 · Best GWAS P=2.77e-10 conditioned to 0.00117

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
39	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	FAM167A	0.29	0.24	lasso	2	0.27	3.5e-11	6.1	6.3	3.6e-10	0.47	0.00	1.00	TRUE
32	NTR	Blood	NEIL2	0.04	0.03	lasso	5	0.02	3.0e-07	5.5	5.9	3.9e-09	0.33	0.08	0.92	TRUE
21	GTEx	Nerve Tibial	ERI1	0.07	0.01	enet	16	0.01	4.2e-02	-5.0	-6.0	1.4e-09	-0.74	0.12	0.66	FALSE
33	ROSMAP	Brain Pre-frontal Cortex	XKR6	0.11	0.10	enet	23	0.13	1.2e-16	-4.8	5.9	3.4e-09	0.64	0.17	0.83	FALSE
40	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	TDH	0.31	0.10	lasso	3	0.13	1.1e-05	6.1	5.7	1.4e-08	0.45	0.00	1.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	FAM86B1	0.02	0.02	lasso	3	0.01	1.3e-02	5.4	5.6	2.3e-08	0.62	0.03	0.90	FALSE
20	GTEx	Muscle Skeletal	NEIL2	0.11	0.08	lasso	5	0.05	4.7e-06	5.5	5.6	2.3e-08	0.42	0.08	0.92	FALSE
29	GTEx	Thyroid	AF131215.2	0.11	0.15	enet	17	0.18	1.2e-13	-4.7	5.6	2.3e-08	0.60	0.75	0.25	FALSE
37	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NEIL2	0.05	0.07	enet	5	0.08	8.1e-09	5.2	5.6	2.6e-08	0.39	0.01	0.99	FALSE
19	GTEx	Muscle Skeletal	MFHAS1	0.07	0.04	lasso	4	0.04	1.4e-04	4.5	5.5	2.9e-08	0.75	0.13	0.85	FALSE
35	ROSMAP	Brain Pre-frontal Cortex	AF131215.3	0.08	0.10	lasso	7	0.12	8.3e-16	5.1	5.5	3.0e-08	0.65	0.50	0.50	FALSE
25	GTEx	Prostate	AF131215.2	0.18	0.02	lasso	6	0.02	9.6e-02	5.1	5.5	3.4e-08	0.59	0.12	0.25	FALSE
17	GTEx	Heart Atrial Appendage	AF131215.9	0.24	0.17	enet	26	0.18	1.3e-08	-4.7	5.5	3.7e-08	0.59	0.27	0.73	FALSE
7	GTEx	Artery Aorta	ERI1	0.11	0.08	lasso	5	0.10	5.1e-06	4.5	-5.5	4.2e-08	-0.71	0.40	0.57	FALSE
15	GTEx	Esophagus Muscularis	FAM85A	0.10	0.01	enet	20	0.04	2.7e-03	-4.4	5.5	4.2e-08	0.47	0.14	0.72	FALSE
3	CommonMind	Brain Pre-frontal Cortex	LOC100506990	0.08	0.03	enet	32	0.05	4.1e-07	5.4	5.4	5.4e-08	0.54	0.02	0.97	FALSE
36	ROSMAP	Brain Pre-frontal Cortex	FAM85A	0.11	0.07	enet	23	0.11	4.3e-14	5.3	5.4	6.3e-08	0.61	0.03	0.97	FALSE
11	GTEx	Breast Mammary Tissue (Female)	AF131215.9	0.04	-0.01	enet	6	0.02	7.3e-02	-4.1	5.4	7.0e-08	0.65	0.07	0.22	FALSE
8	GTEx	Artery Tibial	ERI1	0.05	0.02	lasso	7	0.01	3.2e-02	5.3	-5.4	7.3e-08	-0.80	0.07	0.87	FALSE
4	GTEx	Adipose Subcutaneous	NEIL2	0.12	0.14	enet	19	0.14	3.3e-11	5.3	5.4	7.4e-08	0.38	0.18	0.82	FALSE
31	NTR	Blood	MSRA	0.02	0.01	blup	833	0.01	2.3e-05	4.2	-5.4	8.2e-08	-0.62	0.40	0.59	FALSE
10	GTEx	Breast Mammary Tissue (Male)	FAM85A	0.14	0.03	enet	16	0.09	4.3e-03	-4.3	5.3	8.8e-08	0.51	0.07	0.41	FALSE
6	GTEx	Artery Aorta	FDFT1	0.09	0.02	lasso	4	0.03	6.1e-03	2.2	5.3	9.2e-08	0.53	0.12	0.57	FALSE
5	GTEx	Adrenal Gland	AF131215.9	0.18	0.16	lasso	10	0.18	3.5e-07	4.8	5.3	1.0e-07	0.63	0.44	0.55	FALSE
13	GTEx	Esophagus Mucosa	AF131215.9	0.18	0.16	lasso	14	0.19	1.6e-12	4.9	5.3	1.0e-07	0.63	0.53	0.47	FALSE
2	CommonMind	Brain Pre-frontal Cortex	FAM90A25P	0.11	0.08	lasso	3	0.08	1.4e-09	5.1	5.3	1.1e-07	0.56	0.01	0.99	FALSE
16	GTEx	Esophagus Muscularis	AF131215.9	0.14	0.17	enet	16	0.17	1.6e-10	-4.4	5.3	1.1e-07	0.61	0.64	0.35	FALSE
26	GTEx	Skin Not Sun Exposed Suprapubic	AF131215.2	0.16	0.11	enet	21	0.20	3.9e-11	-4.7	5.3	1.1e-07	0.61	0.73	0.27	FALSE
14	GTEx	Esophagus Muscularis	AF131215.2	0.10	0.08	lasso	5	0.09	2.3e-06	-4.7	5.2	1.5e-07	0.56	0.71	0.27	FALSE
12	GTEx	Colon Sigmoid	AF131215.2	0.10	0.00	enet	7	0.02	5.0e-02	4.6	5.2	1.7e-07	0.67	0.19	0.26	FALSE
23	GTEx	Nerve Tibial	AF131215.2	0.19	0.18	lasso	12	0.23	3.5e-16	-4.7	5.2	1.9e-07	0.60	0.79	0.21	FALSE
27	GTEx	Skin Not Sun Exposed Suprapubic	AF131215.9	0.17	0.14	lasso	8	0.19	9.4e-11	-4.4	5.2	1.9e-07	0.59	0.73	0.27	FALSE
38	The Cancer Genome Atlas	Lung Adenocarcinoma	ERI1	0.06	0.04	blup	72	0.04	1.5e-05	5.1	-5.2	1.9e-07	-0.61	0.00	0.99	FALSE
24	GTEx	Ovary	NEIL2	0.47	0.32	lasso	7	0.26	5.7e-07	5.3	5.2	2.0e-07	0.34	0.19	0.71	FALSE
28	GTEx	Thyroid	SGK223	0.19	0.35	enet	16	0.36	1.1e-28	5.2	-5.2	2.0e-07	-0.77	0.10	0.90	FALSE
30	GTEx	Whole Blood	NEIL2	0.09	0.01	enet	15	0.03	1.5e-03	-3.8	5.2	2.4e-07	0.45	0.31	0.34	FALSE
18	GTEx	Heart Left Ventricle	AF131215.9	0.07	0.10	enet	8	0.10	9.4e-06	-4.4	5.2	2.5e-07	0.59	0.37	0.59	FALSE
34	ROSMAP	Brain Pre-frontal Cortex	FAM66A	0.23	0.26	enet	29	0.30	4.7e-39	5.3	5.2	2.6e-07	0.55	0.01	0.99	FALSE
9	GTEx	Breast Mammary Tissue	AF131215.9	0.10	0.10	lasso	8	0.12	8.7e-07	-4.5	5.1	2.7e-07	0.65	0.57	0.41	FALSE
22	GTEx	Nerve Tibial	NEIL2	0.34	0.20	lasso	6	0.25	8.1e-18	5.3	5.1	2.9e-07	0.37	0.18	0.82	FALSE