Hub : Genes

TDH

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1580	0.0390	4.2e-09	0.069	0.085	0.070	0.088	0.069	7.7e-09	1.6e-10	6.6e-09	8.2e-11	9.7e-09
2	ROSMAP	Brain Pre-frontal Cortex	0.1383	0.0370	1.4e-10	0.107	0.101	0.061	0.100	0.092	1.2e-13	6.4e-13	2.7e-08	7.3e-13	7.8e-12
3	TCGA	Breast Invasive Carcinoma	0.0314	0.0161	4.3e-06	0.042	0.030	0.030	NA	0.034	3.8e-09	6.1e-07	8.2e-07	NA	1.2e-07
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.0491	0.0271	1.7e-05	0.014	0.043	0.032	NA	0.026	9.0e-03	1.3e-05	1.6e-04	NA	5.2e-04
5	TCGA	Lung Adenocarcinoma	0.1057	0.0653	8.1e-05	0.034	0.022	0.043	NA	0.028	7.3e-05	1.1e-03	7.6e-06	NA	2.8e-04
6	TCGA	Pheochromocytoma and Paraganglioma	0.3080	0.0960	2.9e-05	0.097	0.111	0.105	NA	0.126	1.1e-04	3.6e-05	5.9e-05	NA	1.1e-05
7	TCGA	Prostate Adenocarcinoma	0.0591	0.0313	9.9e-06	0.024	0.056	0.049	NA	0.036	1.3e-03	1.5e-06	6.9e-06	NA	1.1e-04
8	TCGA	Thyroid Carcinoma	0.0760	0.0370	3.3e-08	0.085	0.087	0.078	NA	0.083	1.3e-08	8.1e-09	5.3e-08	NA	1.8e-08

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8
Bipolar Disorder (2018)	1.2	1.8	4.6	-1.4	-1.0	-1.0	-1.3	-1.6	2.1	-0.9	-0.9
Bipolar Disorder or Schizophrenia	2.6	6.3	8.3	-2.4	-2.0	-2.1	-2.8	-2.5	2.9	-2.5	-2.8
Depressed Affect (Nagel 2018)	0.4	0.8	2.0	1.4	0.3	-0.1	1.3	0.0	-0.1	0.9	1.2
Depression (Nagel 2018)	0.3	0.4	1.2	-0.2	-1.1	-1.1	-0.4	0.1	0.8	-0.5	-0.4
Intelligence (Savage-Jansen 2018)	0.5	1.5	2.4	1.0	1.1	0.8	1.4	1.5	-1.3	0.9	1.5
Neuroticism (Nagel 2018)	1.0	2.3	5.0	2.1	1.1	0.7	1.9	0.6	0.3	1.8	2.2
Schizophrenia (2018)	2.2	4.6	8.4	-2.0	-1.7	-1.9	-2.5	-1.6	1.8	-2.5	-2.9
Schizophrenia vs Biploar Disorder	0.8	1.1	2.6	-0.3	-0.5	-1.2	-1.1	-0.5	1.1	-1.4	-1.6
Worry (Nagel 2018)	0.3	0.6	1.6	0.8	-0.6	-0.8	0.4	-0.6	1.3	0.8	0.7
Alzheimer’s Disease (in mother)	0.1	0.1	0.2	0.4	-0.4	0.2	-0.4	-0.1	0.4	0.1	-0.1
Alzheimer’s Disease (in father)	0.2	0.2	0.5	-0.6	0.2	0.3	0.4	-0.4	-0.2	0.5	0.7
Alzheimer’s Disease (including proxy)	0.2	0.3	0.6	0.8	-0.2	0.6	0.4	-0.3	-0.4	0.7	0.7
Crohns Disease (2017)	0.8	1.7	5.6	-0.4	-0.6	-1.4	-1.3	-1.0	2.4	-1.2	-1.1
Irritable Bowel Disease (IBD)	0.4	1.0	5.3	0.7	0.3	-0.7	-0.5	-1.0	2.3	-0.3	0.0
Ulcerative Colitis (UC)	0.2	0.4	1.7	0.8	0.1	-0.3	0.0	-1.0	1.3	0.0	0.5
Major Depression (MDD)	0.0	0.1	0.2	0.1	-0.0	-0.3	0.1	0.3	0.1	0.1	0.5
Reaction Time	0.5	1.0	2.9	0.2	1.7	0.8	1.3	0.1	-0.4	1.3	1.0
Verbal and Numeric Reasoning (VNR)	1.4	3.3	5.1	1.6	1.8	1.8	1.7	2.3	-2.0	1.7	1.7
Breast Cancer	2.7	6.5	10.6	-1.9	-2.9	-2.7	-3.2	-1.5	1.5	-3.3	-2.8
Ovarian Cancer	0.3	0.4	2.0	-0.1	0.9	-0.1	-0.2	0.4	1.4	-0.6	0.4
Prostate Cancer	5.5	7.7	13.9	-2.3	-1.7	-3.7	-2.9	-3.2	1.7	-3.3	-2.7
Age at First Birth	0.5	0.7	1.7	-1.0	0.3	1.3	0.6	0.6	-0.9	0.7	0.7
Bipolar Disorder (2011)	1.3	1.3	5.0	-2.2	-0.9	0.0	-1.3	-0.5	0.0	-0.9	-1.3
Body Mass Index (BMI) (2010)	1.6	2.2	3.8	-0.6	-0.9	-1.8	-1.8	-1.4	2.0	-1.8	-1.1
Coronary Artery Disease (CAD)	1.3	1.5	3.9	1.8	2.0	1.7	0.7	0.7	-0.2	0.8	0.8
Crohns Disease (2012)	0.9	1.5	3.2	-0.9	-0.5	-1.1	-1.1	-1.8	1.8	-1.0	-1.1
Mean Putamen Volume	0.2	0.2	0.7	-0.9	0.0	-0.1	-0.4	-0.2	0.5	0.0	-0.8
Fasting Glucose	0.8	0.9	2.0	-0.4	-0.2	-1.4	-1.0	-1.1	1.2	-0.9	-0.6
HbA1C	1.1	1.2	2.4	-1.6	-1.1	-1.1	-0.9	0.1	1.0	-1.4	-1.0
HDL Cholesterol	0.1	0.2	1.1	-0.1	0.7	0.3	0.3	-0.3	-1.1	0.2	-0.1
LDL Cholesterol	0.1	0.2	0.5	-0.1	-0.7	-0.1	-0.6	0.1	0.0	-0.3	-0.6
Lupus	7.4	11.2	16.0	-3.0	-3.0	-3.6	-3.9	-3.0	2.1	-3.7	-4.0
Neuroticism (2016)	27.7	39.9	57.5	4.9	5.8	6.3	7.6	5.4	-5.3	7.6	7.0
Primary Biliary Cirrhosis	0.8	1.1	3.9	-0.4	-0.9	-2.0	-0.6	-0.5	0.8	-1.3	-1.0
Rheumatoid Arthritis	0.4	0.5	1.1	0.7	1.0	0.4	0.8	-0.0	0.4	0.9	1.0
Schizophrenia (2014)	2.8	6.1	10.4	-2.4	-1.9	-2.3	-2.9	-2.2	1.9	-2.7	-3.2
Triglycerides	2.8	4.6	9.4	0.9	0.4	2.2	2.7	1.9	-3.1	2.3	2.4
Type 2 Diabetes (T2D) (2012)	1.5	1.7	3.6	-0.9	-1.1	-1.1	-1.9	-0.3	0.7	-1.8	-1.8
Ulcerative Colitis	0.5	0.7	1.7	1.0	0.8	0.3	0.7	-0.9	0.3	1.0	1.3
Blood Eosinophil Count	0.1	0.8	1.5	-1.2	-0.8	0.6	-1.2	-0.1	0.4	-1.2	-0.7
Blood Platelet Count	0.1	1.1	5.4	2.3	0.1	-0.4	0.8	-0.2	0.5	1.0	1.0
Blood Red Count	0.1	0.5	1.8	0.5	-1.1	0.1	0.0	0.5	-1.3	-0.8	-0.5
Blood White Count	0.7	5.4	14.1	-2.1	-3.8	-1.7	-2.2	-2.4	0.9	-2.4	-2.2
Heel T-Score	0.1	0.5	2.3	0.7	-1.5	-0.4	0.2	0.7	0.6	-0.3	-0.0
BMI	0.3	2.0	6.1	2.5	1.7	-0.5	1.3	-0.6	-0.4	1.3	1.7
Height	0.1	1.2	6.0	0.6	0.7	-2.5	-0.3	-1.3	-0.6	-0.4	-0.5
Waist Hip Ratio (WHR)	0.1	0.3	1.2	1.1	0.4	0.0	0.6	0.2	0.4	0.3	0.6
Systolic Blood Pressure	0.9	4.6	12.7	1.0	3.6	0.5	2.5	-0.4	1.2	2.4	3.0
Smoking Status	0.2	0.5	1.3	-0.1	-0.5	0.9	-0.4	0.7	-1.1	-0.7	-0.9
Allergy or Eczema	0.4	1.0	2.9	1.7	1.1	0.4	1.1	0.6	-0.4	1.1	0.8
Cardiovascular Disease	0.2	0.5	1.7	0.1	1.3	-0.2	0.2	-0.8	1.2	0.2	0.4
Hypothyroidism (self reported)	0.2	0.5	1.4	-1.2	0.6	1.0	-0.1	-0.3	-0.8	0.2	0.2
Respiratory disease	0.2	0.4	1.5	-0.4	-0.2	-0.4	-0.4	-0.7	1.2	-0.4	0.5
Type 2 Diabetes (T2D) (2018)	0.7	1.4	5.4	0.0	-0.9	-2.3	-0.4	-1.9	0.2	-0.6	-0.7
Lung FEV1/FVC ratio	0.0	0.2	0.8	-0.2	-0.3	-0.5	-0.3	-0.4	-0.5	0.1	-0.9
Lung FVC	0.2	1.2	3.0	-0.3	-0.6	-0.7	-1.2	-1.7	0.7	-1.1	-1.4
Neuroticism	0.3	0.8	1.9	0.2	-0.8	-1.3	0.4	-1.2	1.4	0.4	0.6
Chronotype (morning person)	0.3	0.7	4.9	-0.8	-0.1	0.1	0.1	0.3	-2.2	0.0	-0.4
Hair Pigment	0.0	0.4	2.2	-0.5	-1.5	0.3	0.0	0.4	0.2	0.2	0.5
Tanning	0.1	0.9	4.3	-0.4	-0.4	0.4	-1.1	-0.4	2.1	-0.7	-0.8
Hand grip strength (left)	2.0	5.2	7.8	-2.6	-2.4	-2.5	-2.4	-1.7	0.2	-2.8	-2.6
Number of treatments/medications taken	0.3	0.6	3.2	1.1	-0.1	-0.0	-0.5	0.2	1.8	-0.1	-0.0
Average weekly spirits intake	0.5	0.6	2.3	0.3	-0.2	-0.2	1.1	-0.5	-1.5	0.3	0.5
Sensitivity / hurt feelings	11.3	19.4	31.4	3.1	4.6	4.3	5.3	3.4	-2.6	5.3	5.6
Frequency of depressed mood in last 2 weeks	1.2	1.6	4.0	0.4	0.5	0.4	2.0	0.9	-1.8	1.4	1.4
Hearing difficulty/problems: Yes	0.2	0.3	0.8	0.9	-0.1	0.5	0.8	0.2	-0.6	0.8	0.1
Relative age of first facial hair	0.1	0.2	0.8	0.1	0.1	-0.9	0.1	-0.4	0.2	0.4	0.3
Other serious medical condition/disability diagnosed by doctor	1.0	1.2	2.7	0.7	1.6	1.6	0.9	1.0	-0.4	0.9	1.1
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.7	-0.4	-0.6	-0.6	-1.1	-0.4	1.1	-1.0	-1.3
Ever had hysterectomy (womb removed)	4.2	4.7	10.6	-1.1	-3.3	-2.1	-2.3	-1.2	1.3	-2.4	-2.7
Systolic blood pressure, automated reading	4.3	12.5	24.8	-1.8	-2.0	-4.0	-3.4	-4.3	5.0	-3.5	-3.2
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.1	-0.2	-0.0	0.9	0.8	1.1	-0.2	0.9	0.6
Angina	1.1	1.5	2.5	-0.7	-1.4	-1.0	-1.1	-1.6	-1.0	-1.1	-1.5
Medication for hormone replacement therapy	0.6	0.6	1.2	-0.7	-0.5	-0.7	-0.8	-0.6	1.1	-1.0	-0.6
Vitamin and mineral supplements	0.8	1.1	1.7	0.7	1.1	1.2	1.2	0.2	-0.8	1.3	1.3
Supplements: Zinc	0.8	0.8	3.5	-1.1	0.7	-0.4	-0.6	-0.6	1.9	-0.8	-0.4
Medication: Co-codamol	0.4	0.5	1.8	-0.2	-0.2	-1.4	-0.8	0.2	1.0	-0.4	-0.1
Medication: Metformin	2.3	3.2	7.1	-0.5	-1.9	-2.7	-1.6	-2.2	0.9	-1.8	-1.9
Diabetes (father)	2.2	2.7	4.0	-1.5	-0.7	-1.7	-1.9	-1.5	1.5	-2.0	-2.0
Diabetes (mother)	0.4	0.6	0.9	-0.9	-0.8	-0.0	-0.7	-0.7	1.0	-0.6	-0.7
Severe depression (siblings)	0.2	0.2	0.5	-0.5	0.7	0.6	-0.1	0.5	0.7	-0.0	-0.2
Pack years adult smoking proportion	2.9	4.4	9.0	0.4	-1.8	-3.0	-1.8	-2.5	2.5	-2.2	-1.6
Impedance of leg (right)	6.9	33.3	48.9	3.0	4.4	6.2	6.8	5.1	-6.2	7.0	6.3
Leg fat-free mass (left)	3.0	16.0	28.7	-1.0	-2.9	-5.4	-4.3	-4.1	4.3	-4.5	-3.9
Trunk fat percentage	0.8	3.2	8.3	0.4	-1.5	-1.9	-1.8	-2.1	2.9	-1.6	-1.0
Hand grip strength (right)	1.2	3.3	5.8	-1.9	-1.9	-2.4	-1.6	-1.6	-0.6	-1.9	-2.0
Townsend deprivation index at recruitment	0.6	0.9	2.2	0.9	1.5	0.8	0.9	-0.3	0.0	0.9	1.2
Current tobacco smoking	9.1	14.8	20.1	-2.2	-4.1	-4.1	-4.4	-3.6	2.9	-4.5	-4.3
Average weekly fortified wine intake	7.9	9.2	13.3	3.4	3.4	2.4	3.5	2.2	-1.4	3.6	3.5
Maternal smoking around birth	0.1	0.1	0.4	0.6	-0.1	0.2	0.2	0.4	-0.3	0.3	0.2
Fed-up feelings	4.4	8.0	14.5	1.1	1.9	2.3	3.8	2.0	-3.7	3.5	3.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.7	-0.3	-0.2	0.4	0.7	0.7	-0.8	0.5	0.1
Relative age voice broke	0.2	0.3	1.8	-0.1	-0.3	-0.3	0.1	0.4	-1.3	0.3	-0.1
Taking other prescription medications	0.3	0.5	1.8	1.3	0.6	0.7	-0.3	0.9	0.6	-0.3	0.4
Age when periods started (menarche)	0.6	1.3	3.2	0.5	1.8	1.4	0.8	0.3	-1.6	0.9	1.0
Bilateral oophorectomy (both ovaries removed)	1.1	1.2	2.8	-0.2	-1.7	-0.8	-1.2	-0.5	1.3	-1.4	-1.0
Heel bone mineral density (BMD) T-score, automated (left)	18.1	41.0	66.1	-4.1	-5.1	-6.5	-7.7	-4.8	8.1	-7.3	-6.4
Tinnitus: Yes, but not now, but have in the past	1.1	1.1	2.2	-1.0	-1.0	-1.2	-1.5	-0.5	0.7	-1.1	-1.3
Qualifications: CSEs or equivalent	0.5	0.6	2.6	1.6	1.1	-0.3	0.6	-0.2	0.2	0.2	0.7
Serious illness, injury or assault to yourself	0.6	0.7	1.4	0.9	0.6	1.1	0.5	1.2	-0.6	0.8	0.8
High blood pressure	5.2	14.5	33.8	-1.7	-2.5	-3.5	-4.5	-3.2	5.8	-4.2	-3.5
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.7	-0.0	-0.8	-0.8	-0.6	-0.3	0.4	-0.4	-0.7
Multivitamins +/- minerals	0.4	0.5	1.2	-1.0	-0.7	-0.5	-0.7	0.6	-0.2	-0.6	-1.1
Stomach or abdominal pain in last month	4.9	6.1	10.8	1.9	2.1	2.3	3.0	1.9	-2.5	3.3	2.4
Supplements: Glucosamine	0.6	0.8	2.1	-1.3	0.2	0.1	-1.3	0.3	-0.1	-0.7	-1.5
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.9	0.6	0.9	-0.3	0.3	-0.5	0.1	0.1	0.5
Medication: Atenolol	1.8	2.3	4.3	-0.2	-2.0	-1.4	-1.5	-1.2	2.1	-1.5	-1.4
Medication: Levothyroxine sodium	5.7	9.7	14.6	1.3	2.7	3.7	3.4	2.4	-3.8	3.3	3.5
Sitting height	0.7	4.7	12.6	-0.9	-1.5	-3.5	-2.1	-2.2	1.9	-2.0	-2.2
Chronic bronchitis/emphysema (father)	0.3	0.4	0.7	-0.8	-0.8	-0.3	-0.7	-0.6	0.5	-0.6	-0.3
High blood pressure (mother)	0.6	0.9	2.9	0.0	1.0	-0.6	-0.0	-1.5	1.7	-0.6	-0.1
Body mass index (BMI)	5.9	25.0	38.5	-1.5	-4.2	-5.5	-5.7	-4.8	6.2	-5.7	-4.8
Impedance of leg (left)	7.2	34.8	50.6	3.2	4.3	6.5	6.9	5.3	-6.4	7.1	6.3
Leg predicted mass (left)	3.0	16.0	28.7	-1.0	-2.9	-5.4	-4.4	-4.1	4.3	-4.5	-3.9
Trunk fat mass	1.5	6.4	12.4	0.4	-2.1	-3.1	-2.6	-2.8	3.5	-2.5	-1.8
Waist circumference	0.7	2.6	6.0	1.1	-0.8	-2.1	-1.2	-2.2	2.5	-1.2	-0.8
Number of incorrect matches in round	1.6	2.7	5.7	0.9	1.5	1.5	2.4	1.5	-1.2	2.1	1.6
Past tobacco smoking	0.5	1.0	2.1	0.1	0.6	-0.4	1.3	-0.0	-1.2	1.4	1.5
Alcohol usually taken with meals	1.0	1.7	3.8	-0.6	-0.5	-1.3	-1.6	-1.2	0.3	-1.8	-2.0
Nervous feelings	17.9	33.3	49.9	4.3	5.4	5.5	7.1	4.4	-5.6	6.8	6.4
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	0.9	0.2	-0.2	0.1	1.0	-0.4	-0.8	0.8	0.8
Hearing difficulty/problems with background noise	1.7	2.8	4.6	1.9	1.3	1.8	2.1	1.4	-1.5	1.7	1.4
Hair/balding pattern: Pattern 2	0.9	1.1	2.9	-0.7	-0.8	-0.0	-1.6	0.5	1.7	-1.2	-0.8
Had menopause	1.2	1.5	2.2	-0.9	-0.4	-1.5	-1.3	-1.2	1.4	-1.4	-1.2
Had other major operations	2.0	2.4	4.1	0.3	-2.0	-1.6	-1.9	-1.2	1.4	-1.5	-1.9
Forced vital capacity (FVC)	0.6	2.5	7.6	1.0	1.9	1.1	1.5	1.4	-2.7	1.1	1.0
Heel bone mineral density (BMD) T-score, automated (right)	17.9	41.0	63.7	-3.9	-5.6	-6.4	-7.7	-4.3	8.0	-7.4	-6.7
Ever unenthusiastic/disinterested for a whole week	2.4	2.9	4.1	1.6	1.5	1.5	1.9	1.9	-0.5	2.0	2.0
Qualifications: None of the above	0.1	0.2	0.6	-0.1	0.5	0.8	-0.0	-0.6	0.6	0.2	0.3
Financial difficulties in last 2 years	0.6	0.8	1.8	0.1	-0.3	-0.9	-1.2	-0.6	0.6	-1.4	-1.2
Mouth/teeth dental problems	0.7	1.0	2.3	-1.5	-0.2	1.3	0.6	1.2	-1.5	0.4	0.3
Heart attack	0.3	0.4	1.5	1.2	0.8	1.0	0.3	0.2	-0.1	0.2	0.4
Allergy	1.2	2.7	4.0	0.5	1.5	1.8	2.0	1.3	-2.0	1.9	1.7
Pain all over the body in last month	0.8	0.9	2.5	0.1	-1.6	-0.8	-1.2	-0.2	0.3	-0.9	-1.3
Diabetes (self-reported)	1.8	2.7	7.8	-0.2	-1.3	-2.8	-1.3	-1.5	1.9	-1.7	-1.3
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	2.6	1.3	0.9	0.1	1.6	-0.0	-0.5	1.6	1.6
Medication: Ramipril	2.1	2.7	7.1	-0.9	-1.8	-0.8	-2.0	-1.2	2.7	-1.8	-1.1
Medication: Simvastatin	0.5	0.8	1.7	1.0	-0.3	-1.2	-0.3	-1.2	1.3	-0.4	-0.2
Fluid intelligence score	2.1	4.4	6.5	1.8	2.1	2.2	1.9	2.5	-2.4	1.8	1.8
Illnesses of siblings	0.7	1.0	4.3	0.5	0.7	0.9	0.9	2.1	-1.1	0.5	0.4
Neuroticism score	17.6	36.7	60.8	3.9	5.2	5.6	7.8	4.4	-5.7	7.6	7.1
Weight	2.4	12.0	21.7	-0.2	-2.5	-4.7	-3.6	-3.7	4.2	-3.8	-3.1
Impedance of arm (right)	6.6	30.9	43.1	2.6	4.6	6.3	6.1	5.2	-6.2	6.6	5.9
Arm fat percentage (right)	2.5	9.9	19.5	-0.3	-2.6	-3.3	-3.5	-3.4	4.4	-3.3	-2.5
Trunk fat-free mass	1.4	8.3	18.4	-0.4	-1.8	-4.3	-2.9	-3.1	3.0	-3.2	-2.7
Hip circumference	3.2	13.7	21.2	-1.1	-3.0	-4.6	-3.9	-4.3	4.3	-3.9	-3.3
Time employed in main current job	4.4	5.0	8.1	1.1	2.0	2.6	2.7	2.1	-1.5	2.9	2.5
Alcohol intake versus 10 years previously	0.4	0.5	1.1	-0.3	-0.8	-0.9	-0.4	-0.6	-0.6	-1.0	-0.9
Father’s age at death	4.9	6.6	11.1	0.7	1.8	2.8	3.3	1.8	-3.3	3.2	2.3
Worrier / anxious feelings	20.7	39.1	66.7	3.8	5.2	5.9	8.0	4.5	-5.7	8.2	7.3
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.4	0.5	1.2	0.6	1.1	1.1	-0.7	0.6	0.9
Falls in the last year	0.3	0.4	1.4	-0.3	0.1	-0.7	-0.8	-0.3	1.2	-0.6	-0.5
Hair/balding pattern: Pattern 3	1.6	2.3	4.6	0.8	0.8	1.3	1.9	1.4	-2.1	1.9	1.2
Number of live births	0.1	0.2	0.9	0.0	0.9	0.2	0.3	0.3	-0.4	0.2	0.4
Forced expiratory volume in 1-second (FEV1)	1.5	5.2	12.5	1.2	2.3	1.9	2.5	2.0	-3.5	2.2	1.9
Pulse rate	2.5	4.3	13.6	3.7	1.0	1.6	2.2	1.2	0.2	2.3	2.3
Happiness	0.6	0.7	2.0	0.6	0.7	-0.3	1.1	1.0	-1.4	0.7	0.7
Noisy workplace	0.4	0.5	1.0	0.5	-0.0	0.6	0.9	0.9	-0.7	0.8	1.0
Qualifications: A levels/AS levels or equivalent	2.1	4.7	9.4	0.9	1.6	2.4	2.7	1.6	-1.4	3.1	2.8
Serious illness, injury or assault of a close relative in last 2 years	4.6	5.3	7.6	0.4	2.8	2.7	2.7	1.8	-2.5	2.1	2.3
Mouth/teeth dental problems: Dentures	2.1	3.5	9.7	0.7	-1.0	-1.8	-1.9	-2.4	3.1	-1.3	-1.4
Asthma	2.9	5.8	10.2	-1.7	-2.3	-2.0	-3.0	-1.6	3.2	-2.8	-2.1
Medication: Ibuprofen (e.g. Nurofen)	3.0	3.9	6.7	2.1	2.2	1.3	2.6	0.7	-1.2	2.4	2.3
Medication: Cholesterol lowering	0.5	0.8	2.3	1.4	0.9	-0.2	0.4	-1.5	0.9	0.1	0.6
Depression (self-reported)	2.5	3.0	6.8	2.6	1.3	1.1	2.1	0.9	-0.9	2.2	1.8
Medication: Lansoprazole	0.2	0.2	0.5	-0.4	-0.5	-0.1	-0.7	0.1	0.5	-0.4	-0.5
Prospective memory result	0.3	0.4	1.4	-0.8	0.4	-0.4	0.1	-1.2	-0.6	-0.1	-0.7
Lung cancer (father)	0.0	0.1	0.1	-0.3	0.4	0.2	-0.2	0.3	0.2	-0.1	0.0
Illnesses of mother	1.5	1.8	5.0	-1.2	-2.2	-1.7	-1.1	-0.5	-0.2	-1.3	-1.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.6	5.2	8.8	1.7	3.0	1.7	2.7	1.2	-3.0	2.3	2.1
Pulse wave Arterial Stiffness index	1.1	1.3	2.5	-1.4	-1.0	-0.6	-1.3	0.5	1.0	-1.6	-1.4
Impedance of arm (left)	5.9	27.2	38.7	2.3	4.5	5.8	5.8	4.7	-5.7	6.2	5.6
Arm fat mass (right)	3.4	13.9	21.5	-0.5	-3.1	-4.4	-4.2	-3.9	4.6	-4.2	-3.4
Trunk predicted mass	1.4	8.3	18.8	-0.4	-1.8	-4.3	-2.8	-3.1	2.9	-3.3	-2.7
Standing height	1.0	9.5	14.9	3.0	3.2	1.2	3.9	1.9	-3.7	3.4	3.4
Length of working week for main job	1.6	1.8	3.5	-0.2	-1.0	-1.1	-1.8	-0.7	1.5	-1.9	-1.7
Exposure to tobacco smoke at home	0.5	0.5	1.7	-0.1	0.3	-1.3	-0.1	-1.2	0.7	-0.7	-0.3
Breastfed as a baby	2.3	2.8	4.7	1.2	1.6	1.4	2.2	1.2	-1.5	2.1	1.9
Tense / ‘highly strung’	7.3	12.1	23.1	2.3	2.7	3.2	4.8	2.2	-3.6	4.4	3.8
Seen doctor (GP) for nerves, anxiety, tension or depression	4.1	6.2	9.2	2.3	2.2	2.3	3.0	2.2	-2.1	3.0	2.5
Hair/balding pattern: Pattern 4	0.5	1.3	3.5	1.9	1.1	1.7	1.0	0.7	-0.3	0.5	0.8
Birth weight of first child	0.2	0.4	0.8	0.6	-0.9	-0.9	0.6	0.1	0.5	0.6	0.8
Peak expiratory flow (PEF)	2.8	6.5	17.1	1.0	1.6	2.3	2.9	2.7	-4.1	2.4	2.2
Pulse wave reflection index	2.9	3.6	8.8	-3.0	-1.3	-0.9	-2.0	-0.4	0.1	-2.5	-2.6
Ever highly irritable/argumentative for 2 days	0.7	0.9	2.2	0.5	1.5	0.2	1.3	-0.1	-0.3	0.7	1.5
Loud music exposure frequency	0.2	0.2	0.4	-0.6	0.2	0.6	-0.4	-0.5	0.5	-0.6	-0.0
Qualifications: O levels/GCSEs or equivalent	3.3	5.2	8.0	1.3	1.7	2.4	2.4	2.8	-2.4	2.6	2.3
Mouth/teeth dental problems: Bleeding gums	1.4	1.9	4.0	0.2	-0.8	-1.9	-1.6	-0.8	2.0	-1.4	-1.3
Blood clot in the leg (DVT)	2.4	3.1	5.0	0.1	-1.2	-2.1	-2.1	-1.7	1.9	-2.2	-1.6
Medication: Paracetamol	1.6	2.7	3.8	0.8	1.9	1.8	1.7	1.7	-1.7	1.6	1.5
Headache pain in last month	2.2	3.7	5.9	1.3	2.4	1.6	2.4	1.4	-1.4	2.0	2.4
Medication for cholesterol, blood pressure or diabetes	1.2	2.0	5.3	-0.2	0.2	1.5	1.2	2.1	-2.3	1.4	0.8
Glaucoma (self-reported)	1.3	1.5	5.6	0.3	-0.2	-0.8	-1.3	-1.3	2.4	-1.4	-0.6
Gout (self-reported)	0.2	0.3	0.7	0.9	0.7	-0.8	-0.0	-0.6	0.4	-0.2	0.4
Hypothyroidism/myxoedema (self-reported)	8.5	16.7	25.5	1.7	3.9	4.4	4.6	3.2	-5.0	4.5	4.3
Medication: Amlodipine	1.4	2.0	7.8	-0.5	-0.6	-1.7	-0.8	-1.8	2.8	-0.8	-0.4
Medication: Ventolin 100micrograms inhaler	1.4	1.7	2.7	-1.3	-0.7	-1.5	-1.6	-1.3	1.4	-1.3	-1.2
Birth weight	0.3	0.6	1.7	-0.4	-1.2	-1.3	-0.4	-0.9	-0.1	-0.8	-0.3
Chronic bronchitis/emphysema (mother)	1.1	1.3	3.0	1.2	1.4	1.7	0.7	1.3	-0.8	1.0	0.7
High blood pressure (siblings)	0.5	0.8	2.8	-0.1	-0.2	-0.6	-0.3	-1.7	1.7	0.2	0.2
Forced vital capacity (FVC), Best measure	0.3	1.3	3.8	1.0	1.9	0.3	1.2	-0.0	-1.7	0.7	0.7
Body fat percentage	1.2	4.9	12.0	0.3	-1.9	-2.4	-2.2	-2.6	3.5	-2.1	-1.4
Leg fat percentage (right)	1.9	6.9	13.8	0.1	-2.5	-3.0	-2.7	-2.8	3.7	-2.6	-2.0
Arm fat-free mass (right)	2.8	14.3	29.8	-0.4	-2.9	-5.5	-3.8	-4.1	3.7	-4.3	-3.6
Exposure to tobacco smoke outside home	0.8	1.1	3.3	1.5	1.8	0.1	0.9	0.5	-0.3	0.7	1.3
Comparative body size at age 10	9.7	26.7	37.4	-3.8	-6.1	-5.5	-6.0	-2.6	4.4	-6.1	-5.8
Number of full brothers	1.5	1.9	3.2	-1.0	-1.8	-1.0	-1.6	-1.4	1.0	-1.7	-1.5
Worry too long after embarrassment	15.9	26.7	43.6	3.3	4.8	5.0	6.4	4.1	-4.2	6.6	5.9
Seen a psychiatrist for nerves, anxiety, tension or depression	1.5	1.9	5.6	2.4	1.2	0.0	1.6	0.4	-0.4	1.7	1.5
Wheeze or whistling in the chest in last year	2.0	3.5	6.3	-0.4	-1.1	-1.6	-2.5	-1.5	2.3	-2.4	-2.2
Number of children fathered	2.5	2.8	5.0	-1.1	-2.0	-1.5	-2.2	-0.5	0.8	-2.1	-2.1
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	4.8	0.4	1.2	1.0	1.2	0.6	-2.2	1.1	0.4
Age at first live birth	2.4	4.3	8.9	0.5	0.7	2.3	2.6	1.8	-3.0	2.4	1.9
Pulse wave peak to peak time	1.6	1.9	3.5	1.5	1.3	0.8	1.5	-0.3	-1.3	1.9	1.6
Health satisfaction	2.0	2.6	6.1	-0.1	-1.2	-2.2	-1.6	-0.9	2.5	-1.9	-1.1
Shortness of breath walking on level ground	1.0	1.1	4.5	2.1	0.8	0.3	0.9	0.6	0.8	0.7	1.3
Qualifications: College or University degree	0.3	0.9	4.4	-0.5	-0.8	-0.1	0.6	1.1	-2.1	0.2	-0.3
Eye problems/disorders: None of the above	0.6	0.7	2.4	-0.1	1.5	0.2	0.7	0.6	-0.7	0.8	1.0
Mouth/teeth dental problems: Loose teeth	2.0	2.3	6.5	-0.7	-0.6	-1.8	-1.9	-1.2	2.6	-1.5	-1.0
Emphysema/chronic bronchitis	5.1	5.7	13.5	-1.0	-0.9	-2.5	-3.2	-1.7	1.5	-3.7	-2.9
Medication for pain relief, constipation, heartburn	1.5	2.6	4.3	-1.7	-1.6	-1.5	-2.1	-0.9	0.4	-2.0	-1.9
Neck or shoulder pain in last month	0.3	0.4	1.9	0.7	1.4	0.6	0.6	0.3	0.1	0.2	0.6
Medication: Blood pressure	2.7	4.8	8.9	-0.7	-1.6	-2.5	-2.3	-2.2	3.0	-2.5	-1.9
Angina (self-reported)	1.1	1.5	2.3	-0.8	-1.5	-1.0	-1.3	-1.5	-0.6	-1.2	-1.5
Migraine (self-reported)	0.6	0.8	1.5	1.2	0.3	0.6	1.0	0.8	-0.7	1.2	0.8
Medication: Ibuprofen	2.9	3.5	6.0	2.1	2.1	0.9	2.4	0.8	-1.3	2.1	2.2
Medication: Allopurinol	0.4	0.6	1.7	0.1	0.0	-1.0	-1.0	-0.3	0.1	-1.3	-0.9
Medication: Omeprazole	0.2	0.2	0.5	-0.1	-0.6	0.3	-0.5	0.7	0.6	-0.5	-0.3
Medication: Seretide 50 evohaler	0.6	0.7	2.2	-0.3	-0.6	-0.6	-1.2	-0.5	0.2	-1.5	-0.9
Mean time to correctly identify matches	0.3	0.6	1.6	0.3	1.3	0.3	0.8	-0.8	0.6	0.8	0.7
Heart disease (mother)	2.7	3.3	8.2	1.6	2.5	2.9	1.4	1.5	-0.6	1.6	1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	4.2	5.0	7.8	2.2	1.6	2.0	2.8	1.5	-2.8	2.5	2.2
Whole body fat mass	2.1	8.7	15.1	0.1	-2.5	-3.6	-3.1	-3.1	3.9	-3.1	-2.4
Leg fat mass (right)	3.4	13.2	19.8	-0.3	-3.3	-4.4	-3.9	-3.9	4.5	-3.9	-3.2
Arm predicted mass (right)	2.8	14.2	28.3	-0.5	-2.7	-5.3	-3.8	-4.1	3.8	-4.4	-3.7
Pulse rate, automated reading	0.4	1.3	3.1	1.6	-1.8	0.0	-0.7	-0.7	1.7	-0.6	-0.6
Alcohol intake frequency.	0.1	0.3	0.8	0.3	0.9	0.0	0.5	0.3	0.6	0.5	0.9
Comparative height size at age 10	0.2	1.1	2.9	0.0	-0.0	-1.7	-0.6	-1.5	1.5	-1.1	-0.4
Number of full sisters	2.7	3.2	5.5	-1.0	-1.4	-2.4	-2.0	-1.9	2.1	-1.9	-1.4
Suffer from ‘nerves’	5.1	8.0	14.3	1.8	2.6	2.4	3.8	1.9	-3.0	3.3	3.2
Overall health rating	5.1	11.1	16.1	-0.8	-2.6	-3.8	-3.6	-3.4	4.0	-4.0	-3.2
Chest pain or discomfort	0.7	1.0	2.3	0.8	0.9	1.1	1.0	1.1	-1.5	0.7	0.6
Had major operations	0.4	0.5	1.3	-0.6	-0.6	-0.3	-0.7	-1.1	0.2	-0.6	-0.9
Age at last live birth	5.0	7.3	11.5	1.1	2.1	2.9	3.4	2.1	-3.3	3.3	2.6
Family relationship satisfaction	2.5	3.1	5.1	1.8	1.5	1.7	1.8	2.2	-1.1	1.7	1.9
Leg pain on walking	0.5	0.7	1.9	-0.2	-0.1	-0.9	-0.9	0.2	0.3	-1.3	-1.4
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	3.0	1.7	-0.1	0.0	-0.0	-0.3	1.0	0.1	0.3
Commuting to job workplace: Car/motor vehicle	0.3	0.4	0.7	-0.8	-0.7	-0.8	-0.7	-0.1	0.0	-0.8	-0.5
Illness, injury, bereavement, stress in last 2 years	0.4	0.4	0.7	-0.8	-0.8	-0.8	-0.5	-0.2	0.5	-0.8	-0.7
Medication: Aspirin	1.1	1.5	4.3	0.3	-1.3	-0.9	-1.1	-1.4	2.1	-1.1	-0.9
Supplements: Vitamin C	1.6	1.9	3.6	-1.0	-1.2	-0.4	-1.8	-0.6	1.3	-1.9	-1.9
Knee pain experienced in last month	1.1	1.7	3.1	0.2	0.3	-1.6	-1.3	-1.3	1.7	-1.8	-1.3
Hypertension (Self-reported)	5.8	16.2	35.9	-2.0	-2.8	-3.8	-4.7	-3.3	6.0	-4.5	-3.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	0.9	-0.9	-0.9	-0.5	-0.6	-0.3	0.2	-0.4	-0.9
Illnesses of father: Heart disease	0.1	0.1	0.5	-0.7	0.2	0.5	-0.1	0.3	-0.2	0.2	0.0
Illnesses of siblings: Diabetes	3.8	4.7	7.8	-2.5	-2.7	-1.7	-2.3	-1.4	-0.2	-2.5	-2.8
Smoking status: Previous	0.6	0.9	3.8	0.4	0.8	2.0	0.3	1.4	-0.4	0.3	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	3.0	0.6	1.7	-0.2	1.0	-0.1	-0.3	0.9	1.4
Whole body fat-free mass	2.2	12.4	25.3	-0.7	-2.4	-5.0	-3.6	-3.7	3.6	-4.0	-3.4
Leg fat-free mass (right)	2.9	15.7	27.8	-1.0	-2.9	-5.3	-4.3	-4.0	4.2	-4.6	-4.0
Arm fat percentage (left)	2.8	11.1	21.2	-0.4	-2.7	-3.6	-3.7	-3.7	4.6	-3.5	-2.7
Average weekly red wine intake	0.3	0.5	1.8	-0.7	0.2	-0.4	-0.6	0.3	-0.9	-0.4	-1.3
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.7	0.5	-0.5	0.4	-0.2	0.8	-0.5	-0.6	-0.7
Mood swings	4.6	8.3	15.6	2.5	2.2	2.1	3.9	1.6	-2.7	3.5	3.7
Loneliness, isolation	1.5	2.0	3.3	1.8	1.1	1.5	1.7	1.4	-0.7	1.4	1.5
Long-standing illness, disability or infirmity	0.4	0.6	1.6	1.3	1.2	-0.2	-0.2	0.1	1.2	-0.6	0.4
Ever had bowel cancer screening	1.3	1.5	2.4	1.4	0.9	1.5	1.3	0.8	-0.6	1.5	1.4
Diabetes diagnosed by doctor	1.5	2.5	5.9	-0.4	-1.5	-2.4	-1.3	-1.8	1.4	-1.6	-1.6
Ever had stillbirth, spontaneous miscarriage or termination	4.5	4.9	8.6	-1.5	-2.2	-2.8	-2.4	-1.7	0.1	-2.6	-2.9
Friendships satisfaction	0.0	0.0	0.2	0.2	0.1	-0.0	-0.1	0.5	-0.0	-0.1	-0.1
Qualifications: nursing, teaching	0.3	0.4	1.1	-0.2	-0.3	-0.0	0.9	0.6	-1.0	0.9	0.6
Commuting to job workplace: Walk	0.5	0.5	1.6	0.9	1.3	0.1	0.8	-0.6	-0.2	0.8	0.5
Eye problems/disorders: Cataract	0.3	0.4	1.9	-0.4	-1.4	-0.4	-0.2	-0.7	0.4	-0.1	-0.4
Mouth/teeth dental problems: Mouth ulcers	3.1	5.0	7.5	2.4	2.0	2.0	2.7	1.9	-1.7	2.2	2.7
Medication for cholesterol	2.8	4.2	6.9	1.8	1.7	1.8	2.5	0.7	-2.2	2.6	2.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.8	-0.2	0.1	-0.0	-0.8	-1.3	0.8	-0.7	-0.7
Back pain experienced in last month	0.5	0.8	2.1	0.8	0.8	-0.7	-0.8	-0.8	0.8	-1.4	-0.7
Mineral and other dietary supplements	4.5	6.0	10.9	2.1	1.6	2.0	3.2	1.0	-3.3	2.8	2.7
Breast cancer (self-reported)	0.3	0.3	1.1	1.0	-0.2	-0.3	-0.1	0.4	1.0	-0.4	0.2
Asthma (self-reported)	3.1	6.2	10.9	-1.8	-2.4	-2.2	-3.0	-1.8	3.3	-2.8	-2.3
Osteoporosis (self-reported)	2.9	3.6	6.1	0.7	1.9	2.5	2.2	1.1	-2.2	2.1	1.9
Osteoarthritis (self-reported)	0.6	0.8	2.3	1.5	1.1	-0.9	-0.4	-0.7	1.0	-0.3	-0.5
Medication: Aspirin	0.7	0.9	3.1	0.7	-0.9	-0.5	-0.7	-0.9	1.8	-0.8	-0.7
Medication: Gliclazide	0.2	0.2	0.6	-0.4	-0.7	-0.5	-0.4	-0.8	0.3	-0.1	-0.5
Illnesses of father: None of the above (group 1)	2.9	3.6	5.5	1.9	1.8	1.8	2.4	1.2	-1.8	2.2	1.8
Smoking status: Current	9.5	15.1	20.6	-2.3	-4.2	-4.2	-4.5	-3.4	3.1	-4.5	-4.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.6	3.4	8.7	0.4	1.8	2.1	2.0	1.2	-3.0	1.8	1.5
Whole body water mass	2.2	12.3	25.4	-0.5	-2.4	-5.0	-3.6	-3.7	3.7	-4.0	-3.3
Leg predicted mass (right)	2.9	15.7	27.8	-1.0	-2.9	-5.3	-4.3	-3.9	4.2	-4.6	-4.0
Arm fat mass (left)	3.5	14.2	22.5	-0.3	-3.0	-4.4	-4.2	-4.0	4.7	-4.2	-3.3
Number of self-reported non-cancer illnesses	0.3	0.6	2.1	1.3	0.8	0.3	0.1	-0.2	1.5	0.2	0.6
Average weekly champagne plus white wine intake	0.7	0.9	2.4	-0.1	-0.9	-1.6	-0.7	-1.5	0.5	-0.5	-0.9
Miserableness	9.4	16.3	28.2	3.2	3.1	3.8	5.3	3.5	-3.6	4.7	4.5
Guilty feelings	8.4	12.7	18.9	2.6	3.3	3.4	4.3	2.7	-3.3	4.3	4.2
Wears glasses or contact lenses	0.9	1.0	2.8	1.3	0.5	1.7	0.8	0.7	-0.3	1.2	0.8
Ever taken oral contraceptive pill	1.6	1.8	3.8	1.6	0.4	1.1	1.2	1.9	-0.9	1.6	1.3
Hearing aid user	0.5	0.6	1.0	0.9	1.0	0.7	1.0	0.8	-0.6	0.3	0.8
Mother’s age at death	1.9	2.3	6.8	0.9	0.8	1.1	2.3	-0.5	-0.4	2.6	1.8
Financial situation satisfaction	0.7	0.9	2.8	-0.0	-0.6	-1.7	-1.0	-1.0	0.8	-1.0	-0.6
Tinnitus: Yes, now most or all of the time	1.0	1.2	3.5	-0.1	1.1	1.9	1.2	1.1	-0.9	0.8	0.7
Commuting to job workplace: Public transport	3.7	4.4	7.1	1.1	1.9	2.7	2.6	1.9	-1.9	2.4	2.0
Eye problems/disorders: Glaucoma	3.1	3.7	8.9	-0.6	-1.3	-1.4	-2.4	-1.5	3.0	-2.5	-1.5
Medication: Blood pressure	7.3	13.9	32.1	-2.6	-2.7	-3.2	-4.4	-2.5	5.7	-4.1	-3.5
Pain type(s) experienced in last month: Hip pain	0.6	0.7	4.0	0.2	0.6	-0.3	-0.5	-0.2	2.0	-1.1	0.1
Supplements: Fish oil (including cod liver oil)	3.1	4.1	10.8	-1.2	-1.0	-2.2	-2.5	-0.6	3.3	-2.2	-1.8
High cholesterol (Self-reported)	0.5	0.9	2.9	-0.0	-0.4	-0.9	-0.7	-1.7	1.5	-0.8	-0.5
Medication: Bendroflumethiazide	9.5	14.4	21.0	-3.6	-3.1	-3.8	-4.5	-1.8	3.9	-4.6	-4.3
Medication: Paracetamol	1.1	1.8	4.0	0.3	2.0	1.2	1.5	0.9	-1.2	1.4	1.5
Medication: Lisinopril	0.9	1.1	2.0	-0.6	-0.6	-0.9	-1.4	-0.3	1.3	-1.4	-1.3
Medication: Atorvastatin	0.2	0.3	0.8	-0.4	0.1	-0.4	-0.3	-0.9	0.5	-0.7	-0.5
Illnesses of father: High blood pressure	2.1	2.6	5.0	-0.4	-0.9	-2.1	-1.6	-1.8	2.2	-1.7	-1.1
Alcohol drinker status: Never	0.6	0.7	1.5	0.3	1.2	0.4	0.8	0.8	-0.4	1.2	0.8
Ever smoked	0.2	0.3	0.8	0.8	-0.3	0.2	-0.6	0.2	0.4	-0.9	-0.7
Basal metabolic rate	2.3	12.9	25.2	-0.6	-2.5	-5.0	-3.8	-3.8	3.9	-4.1	-3.4
Leg fat percentage (left)	2.0	7.1	13.7	0.2	-2.7	-2.9	-2.8	-2.8	3.7	-2.7	-2.2
Arm fat-free mass (left)	2.1	10.7	22.2	-0.0	-2.3	-4.7	-3.3	-3.4	3.5	-3.8	-3.1
Number of operations (self-reported)	2.5	3.7	6.8	-0.2	-1.9	-2.0	-2.1	-1.8	2.6	-1.9	-1.9
Average weekly beer plus cider intake	6.7	9.7	13.9	2.2	3.7	3.7	3.2	2.3	-2.4	3.5	3.4
Irritability	13.1	22.2	35.9	2.3	3.6	4.7	5.9	3.8	-6.0	5.5	4.7
Risk taking	8.3	12.1	20.2	-1.4	-3.7	-3.6	-4.0	-3.4	2.1	-4.1	-4.5
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.4	-0.6	0.0	-0.0	0.0	-0.1	-0.6	-0.3	-0.3
Fractured/broken bones in last 5 years	0.7	0.9	2.3	0.6	1.2	1.5	0.6	0.6	-0.8	0.9	0.7
Age started oral contraceptive pill	2.0	2.6	3.5	0.8	1.0	1.6	1.9	1.7	-1.8	1.8	1.9
Diastolic blood pressure, automated reading	8.2	25.3	32.4	-3.2	-3.5	-5.4	-5.6	-5.1	5.7	-5.6	-5.4
Ever depressed for a whole week	5.6	6.9	13.3	1.6	2.2	2.2	2.9	3.6	-2.6	2.9	2.6
Unable to work because of sickness or disability	2.5	3.3	6.4	-1.1	-1.8	-1.8	-2.0	-1.5	1.7	-2.5	-1.8
Commuting to job workplace: Cycle	0.3	0.4	1.2	-1.1	-0.6	-0.3	-0.6	-0.3	0.5	-0.7	-0.6
Myopia	0.3	0.5	1.0	-0.1	1.0	1.0	0.4	0.5	-0.3	0.8	0.9
Vascular/heart problems diagnosed by doctor	3.2	8.7	23.7	0.9	1.4	2.8	3.4	2.6	-4.9	3.3	2.5
Cholesterol lowering medication	0.3	0.5	1.2	-0.5	-0.8	-0.6	-0.8	-0.5	0.1	-0.8	-1.1
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.6	-0.1	-0.7	0.2	-0.5	0.8	0.7	-0.4	-0.3
Pain experienced in last month	0.4	0.7	2.7	-1.3	-1.6	-0.0	-0.4	0.4	-0.8	0.2	-0.3
Supplements: Calcium	0.4	0.4	2.5	-0.7	1.6	0.1	0.4	-0.0	-0.4	0.4	0.0
Basal cell carcinoma (self-reported)	0.3	0.3	1.0	-0.5	-1.0	-0.1	-0.4	-0.6	-0.0	0.0	-0.8
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.4	1.2	0.9	1.0	0.5	0.3	-0.2	0.4	0.6
Deep venous thrombosis (DVT) (self-reported)	3.1	4.0	6.7	-0.0	-1.5	-2.3	-2.4	-2.0	2.2	-2.6	-1.9
Heart disease (siblings)	0.5	0.6	1.8	1.4	0.4	0.4	0.6	0.0	-0.1	0.8	1.3
Alcohol drinker status: Previous	0.4	0.5	1.1	-0.8	-1.0	-0.1	-0.4	0.7	-0.7	-0.6	-0.8
Pack years of smoking	1.5	2.2	5.4	1.2	-0.9	-2.3	-0.9	-2.0	1.8	-1.3	-0.7
Impedance of whole body	7.1	36.3	50.7	3.1	4.8	6.7	6.9	5.5	-6.5	7.1	6.5
Leg fat mass (left)	3.3	13.0	19.1	-0.3	-3.4	-4.3	-3.9	-3.7	4.4	-3.9	-3.3
Arm predicted mass (left)	2.2	11.1	22.8	0.0	-2.2	-4.8	-3.4	-3.4	3.6	-3.9	-3.1