Hub : Genes

TDH

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1580 0.0390 4.2e-09 0.069 0.085 0.070 0.088 0.069 7.7e-09 1.6e-10 6.6e-09 8.2e-11 9.7e-09
2 ROSMAP Brain Pre-frontal Cortex 0.1383 0.0370 1.4e-10 0.107 0.101 0.061 0.100 0.092 1.2e-13 6.4e-13 2.7e-08 7.3e-13 7.8e-12
3 TCGA Breast Invasive Carcinoma 0.0314 0.0161 4.3e-06 0.042 0.030 0.030 NA 0.034 3.8e-09 6.1e-07 8.2e-07 NA 1.2e-07
4 TCGA Kidney Renal Clear Cell Carcinoma 0.0491 0.0271 1.7e-05 0.014 0.043 0.032 NA 0.026 9.0e-03 1.3e-05 1.6e-04 NA 5.2e-04
5 TCGA Lung Adenocarcinoma 0.1057 0.0653 8.1e-05 0.034 0.022 0.043 NA 0.028 7.3e-05 1.1e-03 7.6e-06 NA 2.8e-04
6 TCGA Pheochromocytoma and Paraganglioma 0.3080 0.0960 2.9e-05 0.097 0.111 0.105 NA 0.126 1.1e-04 3.6e-05 5.9e-05 NA 1.1e-05
7 TCGA Prostate Adenocarcinoma 0.0591 0.0313 9.9e-06 0.024 0.056 0.049 NA 0.036 1.3e-03 1.5e-06 6.9e-06 NA 1.1e-04
8 TCGA Thyroid Carcinoma 0.0760 0.0370 3.3e-08 0.085 0.087 0.078 NA 0.083 1.3e-08 8.1e-09 5.3e-08 NA 1.8e-08

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bipolar Disorder (2018) 1.2 1.8 4.6 -1.4 -1.0 -1.0 -1.3 -1.6 2.1 -0.9 -0.9
Bipolar Disorder or Schizophrenia 2.6 6.3 8.3 -2.4 -2.0 -2.1 -2.8 -2.5 2.9 -2.5 -2.8
Depressed Affect (Nagel 2018) 0.4 0.8 2.0 1.4 0.3 -0.1 1.3 0.0 -0.1 0.9 1.2
Depression (Nagel 2018) 0.3 0.4 1.2 -0.2 -1.1 -1.1 -0.4 0.1 0.8 -0.5 -0.4
Intelligence (Savage-Jansen 2018) 0.5 1.5 2.4 1.0 1.1 0.8 1.4 1.5 -1.3 0.9 1.5
Neuroticism (Nagel 2018) 1.0 2.3 5.0 2.1 1.1 0.7 1.9 0.6 0.3 1.8 2.2
Schizophrenia (2018) 2.2 4.6 8.4 -2.0 -1.7 -1.9 -2.5 -1.6 1.8 -2.5 -2.9
Schizophrenia vs Biploar Disorder 0.8 1.1 2.6 -0.3 -0.5 -1.2 -1.1 -0.5 1.1 -1.4 -1.6
Worry (Nagel 2018) 0.3 0.6 1.6 0.8 -0.6 -0.8 0.4 -0.6 1.3 0.8 0.7
Alzheimer’s Disease (in mother) 0.1 0.1 0.2 0.4 -0.4 0.2 -0.4 -0.1 0.4 0.1 -0.1
Alzheimer’s Disease (in father) 0.2 0.2 0.5 -0.6 0.2 0.3 0.4 -0.4 -0.2 0.5 0.7
Alzheimer’s Disease (including proxy) 0.2 0.3 0.6 0.8 -0.2 0.6 0.4 -0.3 -0.4 0.7 0.7
Crohns Disease (2017) 0.8 1.7 5.6 -0.4 -0.6 -1.4 -1.3 -1.0 2.4 -1.2 -1.1
Irritable Bowel Disease (IBD) 0.4 1.0 5.3 0.7 0.3 -0.7 -0.5 -1.0 2.3 -0.3 0.0
Ulcerative Colitis (UC) 0.2 0.4 1.7 0.8 0.1 -0.3 0.0 -1.0 1.3 0.0 0.5
Major Depression (MDD) 0.0 0.1 0.2 0.1 -0.0 -0.3 0.1 0.3 0.1 0.1 0.5
Reaction Time 0.5 1.0 2.9 0.2 1.7 0.8 1.3 0.1 -0.4 1.3 1.0
Verbal and Numeric Reasoning (VNR) 1.4 3.3 5.1 1.6 1.8 1.8 1.7 2.3 -2.0 1.7 1.7
Breast Cancer 2.7 6.5 10.6 -1.9 -2.9 -2.7 -3.2 -1.5 1.5 -3.3 -2.8
Ovarian Cancer 0.3 0.4 2.0 -0.1 0.9 -0.1 -0.2 0.4 1.4 -0.6 0.4
Prostate Cancer 5.5 7.7 13.9 -2.3 -1.7 -3.7 -2.9 -3.2 1.7 -3.3 -2.7
Age at First Birth 0.5 0.7 1.7 -1.0 0.3 1.3 0.6 0.6 -0.9 0.7 0.7
Bipolar Disorder (2011) 1.3 1.3 5.0 -2.2 -0.9 0.0 -1.3 -0.5 0.0 -0.9 -1.3
Body Mass Index (BMI) (2010) 1.6 2.2 3.8 -0.6 -0.9 -1.8 -1.8 -1.4 2.0 -1.8 -1.1
Coronary Artery Disease (CAD) 1.3 1.5 3.9 1.8 2.0 1.7 0.7 0.7 -0.2 0.8 0.8
Crohns Disease (2012) 0.9 1.5 3.2 -0.9 -0.5 -1.1 -1.1 -1.8 1.8 -1.0 -1.1
Mean Putamen Volume 0.2 0.2 0.7 -0.9 0.0 -0.1 -0.4 -0.2 0.5 0.0 -0.8
Fasting Glucose 0.8 0.9 2.0 -0.4 -0.2 -1.4 -1.0 -1.1 1.2 -0.9 -0.6
HbA1C 1.1 1.2 2.4 -1.6 -1.1 -1.1 -0.9 0.1 1.0 -1.4 -1.0
HDL Cholesterol 0.1 0.2 1.1 -0.1 0.7 0.3 0.3 -0.3 -1.1 0.2 -0.1
LDL Cholesterol 0.1 0.2 0.5 -0.1 -0.7 -0.1 -0.6 0.1 0.0 -0.3 -0.6
Lupus 7.4 11.2 16.0 -3.0 -3.0 -3.6 -3.9 -3.0 2.1 -3.7 -4.0
Neuroticism (2016) 27.7 39.9 57.5 4.9 5.8 6.3 7.6 5.4 -5.3 7.6 7.0
Primary Biliary Cirrhosis 0.8 1.1 3.9 -0.4 -0.9 -2.0 -0.6 -0.5 0.8 -1.3 -1.0
Rheumatoid Arthritis 0.4 0.5 1.1 0.7 1.0 0.4 0.8 -0.0 0.4 0.9 1.0
Schizophrenia (2014) 2.8 6.1 10.4 -2.4 -1.9 -2.3 -2.9 -2.2 1.9 -2.7 -3.2
Triglycerides 2.8 4.6 9.4 0.9 0.4 2.2 2.7 1.9 -3.1 2.3 2.4
Type 2 Diabetes (T2D) (2012) 1.5 1.7 3.6 -0.9 -1.1 -1.1 -1.9 -0.3 0.7 -1.8 -1.8
Ulcerative Colitis 0.5 0.7 1.7 1.0 0.8 0.3 0.7 -0.9 0.3 1.0 1.3
Blood Eosinophil Count 0.1 0.8 1.5 -1.2 -0.8 0.6 -1.2 -0.1 0.4 -1.2 -0.7
Blood Platelet Count 0.1 1.1 5.4 2.3 0.1 -0.4 0.8 -0.2 0.5 1.0 1.0
Blood Red Count 0.1 0.5 1.8 0.5 -1.1 0.1 0.0 0.5 -1.3 -0.8 -0.5
Blood White Count 0.7 5.4 14.1 -2.1 -3.8 -1.7 -2.2 -2.4 0.9 -2.4 -2.2
Heel T-Score 0.1 0.5 2.3 0.7 -1.5 -0.4 0.2 0.7 0.6 -0.3 -0.0
BMI 0.3 2.0 6.1 2.5 1.7 -0.5 1.3 -0.6 -0.4 1.3 1.7
Height 0.1 1.2 6.0 0.6 0.7 -2.5 -0.3 -1.3 -0.6 -0.4 -0.5
Waist Hip Ratio (WHR) 0.1 0.3 1.2 1.1 0.4 0.0 0.6 0.2 0.4 0.3 0.6
Systolic Blood Pressure 0.9 4.6 12.7 1.0 3.6 0.5 2.5 -0.4 1.2 2.4 3.0
Smoking Status 0.2 0.5 1.3 -0.1 -0.5 0.9 -0.4 0.7 -1.1 -0.7 -0.9
Allergy or Eczema 0.4 1.0 2.9 1.7 1.1 0.4 1.1 0.6 -0.4 1.1 0.8
Cardiovascular Disease 0.2 0.5 1.7 0.1 1.3 -0.2 0.2 -0.8 1.2 0.2 0.4
Hypothyroidism (self reported) 0.2 0.5 1.4 -1.2 0.6 1.0 -0.1 -0.3 -0.8 0.2 0.2
Respiratory disease 0.2 0.4 1.5 -0.4 -0.2 -0.4 -0.4 -0.7 1.2 -0.4 0.5
Type 2 Diabetes (T2D) (2018) 0.7 1.4 5.4 0.0 -0.9 -2.3 -0.4 -1.9 0.2 -0.6 -0.7
Lung FEV1/FVC ratio 0.0 0.2 0.8 -0.2 -0.3 -0.5 -0.3 -0.4 -0.5 0.1 -0.9
Lung FVC 0.2 1.2 3.0 -0.3 -0.6 -0.7 -1.2 -1.7 0.7 -1.1 -1.4
Neuroticism 0.3 0.8 1.9 0.2 -0.8 -1.3 0.4 -1.2 1.4 0.4 0.6
Chronotype (morning person) 0.3 0.7 4.9 -0.8 -0.1 0.1 0.1 0.3 -2.2 0.0 -0.4
Hair Pigment 0.0 0.4 2.2 -0.5 -1.5 0.3 0.0 0.4 0.2 0.2 0.5
Tanning 0.1 0.9 4.3 -0.4 -0.4 0.4 -1.1 -0.4 2.1 -0.7 -0.8
Hand grip strength (left) 2.0 5.2 7.8 -2.6 -2.4 -2.5 -2.4 -1.7 0.2 -2.8 -2.6
Number of treatments/medications taken 0.3 0.6 3.2 1.1 -0.1 -0.0 -0.5 0.2 1.8 -0.1 -0.0
Average weekly spirits intake 0.5 0.6 2.3 0.3 -0.2 -0.2 1.1 -0.5 -1.5 0.3 0.5
Sensitivity / hurt feelings 11.3 19.4 31.4 3.1 4.6 4.3 5.3 3.4 -2.6 5.3 5.6
Frequency of depressed mood in last 2 weeks 1.2 1.6 4.0 0.4 0.5 0.4 2.0 0.9 -1.8 1.4 1.4
Hearing difficulty/problems: Yes 0.2 0.3 0.8 0.9 -0.1 0.5 0.8 0.2 -0.6 0.8 0.1
Relative age of first facial hair 0.1 0.2 0.8 0.1 0.1 -0.9 0.1 -0.4 0.2 0.4 0.3
Other serious medical condition/disability diagnosed by doctor 1.0 1.2 2.7 0.7 1.6 1.6 0.9 1.0 -0.4 0.9 1.1
Ever used hormone-replacement therapy (HRT) 0.6 0.8 1.7 -0.4 -0.6 -0.6 -1.1 -0.4 1.1 -1.0 -1.3
Ever had hysterectomy (womb removed) 4.2 4.7 10.6 -1.1 -3.3 -2.1 -2.3 -1.2 1.3 -2.4 -2.7
Systolic blood pressure, automated reading 4.3 12.5 24.8 -1.8 -2.0 -4.0 -3.4 -4.3 5.0 -3.5 -3.2
Eye problems/disorders: Diabetes related eye disease 0.4 0.5 1.1 -0.2 -0.0 0.9 0.8 1.1 -0.2 0.9 0.6
Angina 1.1 1.5 2.5 -0.7 -1.4 -1.0 -1.1 -1.6 -1.0 -1.1 -1.5
Medication for hormone replacement therapy 0.6 0.6 1.2 -0.7 -0.5 -0.7 -0.8 -0.6 1.1 -1.0 -0.6
Vitamin and mineral supplements 0.8 1.1 1.7 0.7 1.1 1.2 1.2 0.2 -0.8 1.3 1.3
Supplements: Zinc 0.8 0.8 3.5 -1.1 0.7 -0.4 -0.6 -0.6 1.9 -0.8 -0.4
Medication: Co-codamol 0.4 0.5 1.8 -0.2 -0.2 -1.4 -0.8 0.2 1.0 -0.4 -0.1
Medication: Metformin 2.3 3.2 7.1 -0.5 -1.9 -2.7 -1.6 -2.2 0.9 -1.8 -1.9
Diabetes (father) 2.2 2.7 4.0 -1.5 -0.7 -1.7 -1.9 -1.5 1.5 -2.0 -2.0
Diabetes (mother) 0.4 0.6 0.9 -0.9 -0.8 -0.0 -0.7 -0.7 1.0 -0.6 -0.7
Severe depression (siblings) 0.2 0.2 0.5 -0.5 0.7 0.6 -0.1 0.5 0.7 -0.0 -0.2
Pack years adult smoking proportion 2.9 4.4 9.0 0.4 -1.8 -3.0 -1.8 -2.5 2.5 -2.2 -1.6
Impedance of leg (right) 6.9 33.3 48.9 3.0 4.4 6.2 6.8 5.1 -6.2 7.0 6.3
Leg fat-free mass (left) 3.0 16.0 28.7 -1.0 -2.9 -5.4 -4.3 -4.1 4.3 -4.5 -3.9
Trunk fat percentage 0.8 3.2 8.3 0.4 -1.5 -1.9 -1.8 -2.1 2.9 -1.6 -1.0
Hand grip strength (right) 1.2 3.3 5.8 -1.9 -1.9 -2.4 -1.6 -1.6 -0.6 -1.9 -2.0
Townsend deprivation index at recruitment 0.6 0.9 2.2 0.9 1.5 0.8 0.9 -0.3 0.0 0.9 1.2
Current tobacco smoking 9.1 14.8 20.1 -2.2 -4.1 -4.1 -4.4 -3.6 2.9 -4.5 -4.3
Average weekly fortified wine intake 7.9 9.2 13.3 3.4 3.4 2.4 3.5 2.2 -1.4 3.6 3.5
Maternal smoking around birth 0.1 0.1 0.4 0.6 -0.1 0.2 0.2 0.4 -0.3 0.3 0.2
Fed-up feelings 4.4 8.0 14.5 1.1 1.9 2.3 3.8 2.0 -3.7 3.5 3.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 0.7 -0.3 -0.2 0.4 0.7 0.7 -0.8 0.5 0.1
Relative age voice broke 0.2 0.3 1.8 -0.1 -0.3 -0.3 0.1 0.4 -1.3 0.3 -0.1
Taking other prescription medications 0.3 0.5 1.8 1.3 0.6 0.7 -0.3 0.9 0.6 -0.3 0.4
Age when periods started (menarche) 0.6 1.3 3.2 0.5 1.8 1.4 0.8 0.3 -1.6 0.9 1.0
Bilateral oophorectomy (both ovaries removed) 1.1 1.2 2.8 -0.2 -1.7 -0.8 -1.2 -0.5 1.3 -1.4 -1.0
Heel bone mineral density (BMD) T-score, automated (left) 18.1 41.0 66.1 -4.1 -5.1 -6.5 -7.7 -4.8 8.1 -7.3 -6.4
Tinnitus: Yes, but not now, but have in the past 1.1 1.1 2.2 -1.0 -1.0 -1.2 -1.5 -0.5 0.7 -1.1 -1.3
Qualifications: CSEs or equivalent 0.5 0.6 2.6 1.6 1.1 -0.3 0.6 -0.2 0.2 0.2 0.7
Serious illness, injury or assault to yourself 0.6 0.7 1.4 0.9 0.6 1.1 0.5 1.2 -0.6 0.8 0.8
High blood pressure 5.2 14.5 33.8 -1.7 -2.5 -3.5 -4.5 -3.2 5.8 -4.2 -3.5
Hayfever, allergic rhinitis or eczema 0.1 0.3 0.7 -0.0 -0.8 -0.8 -0.6 -0.3 0.4 -0.4 -0.7
Multivitamins +/- minerals 0.4 0.5 1.2 -1.0 -0.7 -0.5 -0.7 0.6 -0.2 -0.6 -1.1
Stomach or abdominal pain in last month 4.9 6.1 10.8 1.9 2.1 2.3 3.0 1.9 -2.5 3.3 2.4
Supplements: Glucosamine 0.6 0.8 2.1 -1.3 0.2 0.1 -1.3 0.3 -0.1 -0.7 -1.5
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.9 0.6 0.9 -0.3 0.3 -0.5 0.1 0.1 0.5
Medication: Atenolol 1.8 2.3 4.3 -0.2 -2.0 -1.4 -1.5 -1.2 2.1 -1.5 -1.4
Medication: Levothyroxine sodium 5.7 9.7 14.6 1.3 2.7 3.7 3.4 2.4 -3.8 3.3 3.5
Sitting height 0.7 4.7 12.6 -0.9 -1.5 -3.5 -2.1 -2.2 1.9 -2.0 -2.2
Chronic bronchitis/emphysema (father) 0.3 0.4 0.7 -0.8 -0.8 -0.3 -0.7 -0.6 0.5 -0.6 -0.3
High blood pressure (mother) 0.6 0.9 2.9 0.0 1.0 -0.6 -0.0 -1.5 1.7 -0.6 -0.1
Body mass index (BMI) 5.9 25.0 38.5 -1.5 -4.2 -5.5 -5.7 -4.8 6.2 -5.7 -4.8
Impedance of leg (left) 7.2 34.8 50.6 3.2 4.3 6.5 6.9 5.3 -6.4 7.1 6.3
Leg predicted mass (left) 3.0 16.0 28.7 -1.0 -2.9 -5.4 -4.4 -4.1 4.3 -4.5 -3.9
Trunk fat mass 1.5 6.4 12.4 0.4 -2.1 -3.1 -2.6 -2.8 3.5 -2.5 -1.8
Waist circumference 0.7 2.6 6.0 1.1 -0.8 -2.1 -1.2 -2.2 2.5 -1.2 -0.8
Number of incorrect matches in round 1.6 2.7 5.7 0.9 1.5 1.5 2.4 1.5 -1.2 2.1 1.6
Past tobacco smoking 0.5 1.0 2.1 0.1 0.6 -0.4 1.3 -0.0 -1.2 1.4 1.5
Alcohol usually taken with meals 1.0 1.7 3.8 -0.6 -0.5 -1.3 -1.6 -1.2 0.3 -1.8 -2.0
Nervous feelings 17.9 33.3 49.9 4.3 5.4 5.5 7.1 4.4 -5.6 6.8 6.4
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.4 0.9 0.2 -0.2 0.1 1.0 -0.4 -0.8 0.8 0.8
Hearing difficulty/problems with background noise 1.7 2.8 4.6 1.9 1.3 1.8 2.1 1.4 -1.5 1.7 1.4
Hair/balding pattern: Pattern 2 0.9 1.1 2.9 -0.7 -0.8 -0.0 -1.6 0.5 1.7 -1.2 -0.8
Had menopause 1.2 1.5 2.2 -0.9 -0.4 -1.5 -1.3 -1.2 1.4 -1.4 -1.2
Had other major operations 2.0 2.4 4.1 0.3 -2.0 -1.6 -1.9 -1.2 1.4 -1.5 -1.9
Forced vital capacity (FVC) 0.6 2.5 7.6 1.0 1.9 1.1 1.5 1.4 -2.7 1.1 1.0
Heel bone mineral density (BMD) T-score, automated (right) 17.9 41.0 63.7 -3.9 -5.6 -6.4 -7.7 -4.3 8.0 -7.4 -6.7
Ever unenthusiastic/disinterested for a whole week 2.4 2.9 4.1 1.6 1.5 1.5 1.9 1.9 -0.5 2.0 2.0
Qualifications: None of the above 0.1 0.2 0.6 -0.1 0.5 0.8 -0.0 -0.6 0.6 0.2 0.3
Financial difficulties in last 2 years 0.6 0.8 1.8 0.1 -0.3 -0.9 -1.2 -0.6 0.6 -1.4 -1.2
Mouth/teeth dental problems 0.7 1.0 2.3 -1.5 -0.2 1.3 0.6 1.2 -1.5 0.4 0.3
Heart attack 0.3 0.4 1.5 1.2 0.8 1.0 0.3 0.2 -0.1 0.2 0.4
Allergy 1.2 2.7 4.0 0.5 1.5 1.8 2.0 1.3 -2.0 1.9 1.7
Pain all over the body in last month 0.8 0.9 2.5 0.1 -1.6 -0.8 -1.2 -0.2 0.3 -0.9 -1.3
Diabetes (self-reported) 1.8 2.7 7.8 -0.2 -1.3 -2.8 -1.3 -1.5 1.9 -1.7 -1.3
Hayfever/allergic rhinitis (self-reported) 1.0 1.3 2.6 1.3 0.9 0.1 1.6 -0.0 -0.5 1.6 1.6
Medication: Ramipril 2.1 2.7 7.1 -0.9 -1.8 -0.8 -2.0 -1.2 2.7 -1.8 -1.1
Medication: Simvastatin 0.5 0.8 1.7 1.0 -0.3 -1.2 -0.3 -1.2 1.3 -0.4 -0.2
Fluid intelligence score 2.1 4.4 6.5 1.8 2.1 2.2 1.9 2.5 -2.4 1.8 1.8
Illnesses of siblings 0.7 1.0 4.3 0.5 0.7 0.9 0.9 2.1 -1.1 0.5 0.4
Neuroticism score 17.6 36.7 60.8 3.9 5.2 5.6 7.8 4.4 -5.7 7.6 7.1
Weight 2.4 12.0 21.7 -0.2 -2.5 -4.7 -3.6 -3.7 4.2 -3.8 -3.1
Impedance of arm (right) 6.6 30.9 43.1 2.6 4.6 6.3 6.1 5.2 -6.2 6.6 5.9
Arm fat percentage (right) 2.5 9.9 19.5 -0.3 -2.6 -3.3 -3.5 -3.4 4.4 -3.3 -2.5
Trunk fat-free mass 1.4 8.3 18.4 -0.4 -1.8 -4.3 -2.9 -3.1 3.0 -3.2 -2.7
Hip circumference 3.2 13.7 21.2 -1.1 -3.0 -4.6 -3.9 -4.3 4.3 -3.9 -3.3
Time employed in main current job 4.4 5.0 8.1 1.1 2.0 2.6 2.7 2.1 -1.5 2.9 2.5
Alcohol intake versus 10 years previously 0.4 0.5 1.1 -0.3 -0.8 -0.9 -0.4 -0.6 -0.6 -1.0 -0.9
Father’s age at death 4.9 6.6 11.1 0.7 1.8 2.8 3.3 1.8 -3.3 3.2 2.3
Worrier / anxious feelings 20.7 39.1 66.7 3.8 5.2 5.9 8.0 4.5 -5.7 8.2 7.3
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.8 1.4 0.5 1.2 0.6 1.1 1.1 -0.7 0.6 0.9
Falls in the last year 0.3 0.4 1.4 -0.3 0.1 -0.7 -0.8 -0.3 1.2 -0.6 -0.5
Hair/balding pattern: Pattern 3 1.6 2.3 4.6 0.8 0.8 1.3 1.9 1.4 -2.1 1.9 1.2
Number of live births 0.1 0.2 0.9 0.0 0.9 0.2 0.3 0.3 -0.4 0.2 0.4
Forced expiratory volume in 1-second (FEV1) 1.5 5.2 12.5 1.2 2.3 1.9 2.5 2.0 -3.5 2.2 1.9
Pulse rate 2.5 4.3 13.6 3.7 1.0 1.6 2.2 1.2 0.2 2.3 2.3
Happiness 0.6 0.7 2.0 0.6 0.7 -0.3 1.1 1.0 -1.4 0.7 0.7
Noisy workplace 0.4 0.5 1.0 0.5 -0.0 0.6 0.9 0.9 -0.7 0.8 1.0
Qualifications: A levels/AS levels or equivalent 2.1 4.7 9.4 0.9 1.6 2.4 2.7 1.6 -1.4 3.1 2.8
Serious illness, injury or assault of a close relative in last 2 years 4.6 5.3 7.6 0.4 2.8 2.7 2.7 1.8 -2.5 2.1 2.3
Mouth/teeth dental problems: Dentures 2.1 3.5 9.7 0.7 -1.0 -1.8 -1.9 -2.4 3.1 -1.3 -1.4
Asthma 2.9 5.8 10.2 -1.7 -2.3 -2.0 -3.0 -1.6 3.2 -2.8 -2.1
Medication: Ibuprofen (e.g. Nurofen) 3.0 3.9 6.7 2.1 2.2 1.3 2.6 0.7 -1.2 2.4 2.3
Medication: Cholesterol lowering 0.5 0.8 2.3 1.4 0.9 -0.2 0.4 -1.5 0.9 0.1 0.6
Depression (self-reported) 2.5 3.0 6.8 2.6 1.3 1.1 2.1 0.9 -0.9 2.2 1.8
Medication: Lansoprazole 0.2 0.2 0.5 -0.4 -0.5 -0.1 -0.7 0.1 0.5 -0.4 -0.5
Prospective memory result 0.3 0.4 1.4 -0.8 0.4 -0.4 0.1 -1.2 -0.6 -0.1 -0.7
Lung cancer (father) 0.0 0.1 0.1 -0.3 0.4 0.2 -0.2 0.3 0.2 -0.1 0.0
Illnesses of mother 1.5 1.8 5.0 -1.2 -2.2 -1.7 -1.1 -0.5 -0.2 -1.3 -1.3
Forced expiratory volume in 1-second (FEV1), Best measure 1.6 5.2 8.8 1.7 3.0 1.7 2.7 1.2 -3.0 2.3 2.1
Pulse wave Arterial Stiffness index 1.1 1.3 2.5 -1.4 -1.0 -0.6 -1.3 0.5 1.0 -1.6 -1.4
Impedance of arm (left) 5.9 27.2 38.7 2.3 4.5 5.8 5.8 4.7 -5.7 6.2 5.6
Arm fat mass (right) 3.4 13.9 21.5 -0.5 -3.1 -4.4 -4.2 -3.9 4.6 -4.2 -3.4
Trunk predicted mass 1.4 8.3 18.8 -0.4 -1.8 -4.3 -2.8 -3.1 2.9 -3.3 -2.7
Standing height 1.0 9.5 14.9 3.0 3.2 1.2 3.9 1.9 -3.7 3.4 3.4
Length of working week for main job 1.6 1.8 3.5 -0.2 -1.0 -1.1 -1.8 -0.7 1.5 -1.9 -1.7
Exposure to tobacco smoke at home 0.5 0.5 1.7 -0.1 0.3 -1.3 -0.1 -1.2 0.7 -0.7 -0.3
Breastfed as a baby 2.3 2.8 4.7 1.2 1.6 1.4 2.2 1.2 -1.5 2.1 1.9
Tense / ‘highly strung’ 7.3 12.1 23.1 2.3 2.7 3.2 4.8 2.2 -3.6 4.4 3.8
Seen doctor (GP) for nerves, anxiety, tension or depression 4.1 6.2 9.2 2.3 2.2 2.3 3.0 2.2 -2.1 3.0 2.5
Hair/balding pattern: Pattern 4 0.5 1.3 3.5 1.9 1.1 1.7 1.0 0.7 -0.3 0.5 0.8
Birth weight of first child 0.2 0.4 0.8 0.6 -0.9 -0.9 0.6 0.1 0.5 0.6 0.8
Peak expiratory flow (PEF) 2.8 6.5 17.1 1.0 1.6 2.3 2.9 2.7 -4.1 2.4 2.2
Pulse wave reflection index 2.9 3.6 8.8 -3.0 -1.3 -0.9 -2.0 -0.4 0.1 -2.5 -2.6
Ever highly irritable/argumentative for 2 days 0.7 0.9 2.2 0.5 1.5 0.2 1.3 -0.1 -0.3 0.7 1.5
Loud music exposure frequency 0.2 0.2 0.4 -0.6 0.2 0.6 -0.4 -0.5 0.5 -0.6 -0.0
Qualifications: O levels/GCSEs or equivalent 3.3 5.2 8.0 1.3 1.7 2.4 2.4 2.8 -2.4 2.6 2.3
Mouth/teeth dental problems: Bleeding gums 1.4 1.9 4.0 0.2 -0.8 -1.9 -1.6 -0.8 2.0 -1.4 -1.3
Blood clot in the leg (DVT) 2.4 3.1 5.0 0.1 -1.2 -2.1 -2.1 -1.7 1.9 -2.2 -1.6
Medication: Paracetamol 1.6 2.7 3.8 0.8 1.9 1.8 1.7 1.7 -1.7 1.6 1.5
Headache pain in last month 2.2 3.7 5.9 1.3 2.4 1.6 2.4 1.4 -1.4 2.0 2.4
Medication for cholesterol, blood pressure or diabetes 1.2 2.0 5.3 -0.2 0.2 1.5 1.2 2.1 -2.3 1.4 0.8
Glaucoma (self-reported) 1.3 1.5 5.6 0.3 -0.2 -0.8 -1.3 -1.3 2.4 -1.4 -0.6
Gout (self-reported) 0.2 0.3 0.7 0.9 0.7 -0.8 -0.0 -0.6 0.4 -0.2 0.4
Hypothyroidism/myxoedema (self-reported) 8.5 16.7 25.5 1.7 3.9 4.4 4.6 3.2 -5.0 4.5 4.3
Medication: Amlodipine 1.4 2.0 7.8 -0.5 -0.6 -1.7 -0.8 -1.8 2.8 -0.8 -0.4
Medication: Ventolin 100micrograms inhaler 1.4 1.7 2.7 -1.3 -0.7 -1.5 -1.6 -1.3 1.4 -1.3 -1.2
Birth weight 0.3 0.6 1.7 -0.4 -1.2 -1.3 -0.4 -0.9 -0.1 -0.8 -0.3
Chronic bronchitis/emphysema (mother) 1.1 1.3 3.0 1.2 1.4 1.7 0.7 1.3 -0.8 1.0 0.7
High blood pressure (siblings) 0.5 0.8 2.8 -0.1 -0.2 -0.6 -0.3 -1.7 1.7 0.2 0.2
Forced vital capacity (FVC), Best measure 0.3 1.3 3.8 1.0 1.9 0.3 1.2 -0.0 -1.7 0.7 0.7
Body fat percentage 1.2 4.9 12.0 0.3 -1.9 -2.4 -2.2 -2.6 3.5 -2.1 -1.4
Leg fat percentage (right) 1.9 6.9 13.8 0.1 -2.5 -3.0 -2.7 -2.8 3.7 -2.6 -2.0
Arm fat-free mass (right) 2.8 14.3 29.8 -0.4 -2.9 -5.5 -3.8 -4.1 3.7 -4.3 -3.6
Exposure to tobacco smoke outside home 0.8 1.1 3.3 1.5 1.8 0.1 0.9 0.5 -0.3 0.7 1.3
Comparative body size at age 10 9.7 26.7 37.4 -3.8 -6.1 -5.5 -6.0 -2.6 4.4 -6.1 -5.8
Number of full brothers 1.5 1.9 3.2 -1.0 -1.8 -1.0 -1.6 -1.4 1.0 -1.7 -1.5
Worry too long after embarrassment 15.9 26.7 43.6 3.3 4.8 5.0 6.4 4.1 -4.2 6.6 5.9
Seen a psychiatrist for nerves, anxiety, tension or depression 1.5 1.9 5.6 2.4 1.2 0.0 1.6 0.4 -0.4 1.7 1.5
Wheeze or whistling in the chest in last year 2.0 3.5 6.3 -0.4 -1.1 -1.6 -2.5 -1.5 2.3 -2.4 -2.2
Number of children fathered 2.5 2.8 5.0 -1.1 -2.0 -1.5 -2.2 -0.5 0.8 -2.1 -2.1
Reason for reducing amount of alcohol drunk: Health precaution 1.1 1.3 4.8 0.4 1.2 1.0 1.2 0.6 -2.2 1.1 0.4
Age at first live birth 2.4 4.3 8.9 0.5 0.7 2.3 2.6 1.8 -3.0 2.4 1.9
Pulse wave peak to peak time 1.6 1.9 3.5 1.5 1.3 0.8 1.5 -0.3 -1.3 1.9 1.6
Health satisfaction 2.0 2.6 6.1 -0.1 -1.2 -2.2 -1.6 -0.9 2.5 -1.9 -1.1
Shortness of breath walking on level ground 1.0 1.1 4.5 2.1 0.8 0.3 0.9 0.6 0.8 0.7 1.3
Qualifications: College or University degree 0.3 0.9 4.4 -0.5 -0.8 -0.1 0.6 1.1 -2.1 0.2 -0.3
Eye problems/disorders: None of the above 0.6 0.7 2.4 -0.1 1.5 0.2 0.7 0.6 -0.7 0.8 1.0
Mouth/teeth dental problems: Loose teeth 2.0 2.3 6.5 -0.7 -0.6 -1.8 -1.9 -1.2 2.6 -1.5 -1.0
Emphysema/chronic bronchitis 5.1 5.7 13.5 -1.0 -0.9 -2.5 -3.2 -1.7 1.5 -3.7 -2.9
Medication for pain relief, constipation, heartburn 1.5 2.6 4.3 -1.7 -1.6 -1.5 -2.1 -0.9 0.4 -2.0 -1.9
Neck or shoulder pain in last month 0.3 0.4 1.9 0.7 1.4 0.6 0.6 0.3 0.1 0.2 0.6
Medication: Blood pressure 2.7 4.8 8.9 -0.7 -1.6 -2.5 -2.3 -2.2 3.0 -2.5 -1.9
Angina (self-reported) 1.1 1.5 2.3 -0.8 -1.5 -1.0 -1.3 -1.5 -0.6 -1.2 -1.5
Migraine (self-reported) 0.6 0.8 1.5 1.2 0.3 0.6 1.0 0.8 -0.7 1.2 0.8
Medication: Ibuprofen 2.9 3.5 6.0 2.1 2.1 0.9 2.4 0.8 -1.3 2.1 2.2
Medication: Allopurinol 0.4 0.6 1.7 0.1 0.0 -1.0 -1.0 -0.3 0.1 -1.3 -0.9
Medication: Omeprazole 0.2 0.2 0.5 -0.1 -0.6 0.3 -0.5 0.7 0.6 -0.5 -0.3
Medication: Seretide 50 evohaler 0.6 0.7 2.2 -0.3 -0.6 -0.6 -1.2 -0.5 0.2 -1.5 -0.9
Mean time to correctly identify matches 0.3 0.6 1.6 0.3 1.3 0.3 0.8 -0.8 0.6 0.8 0.7
Heart disease (mother) 2.7 3.3 8.2 1.6 2.5 2.9 1.4 1.5 -0.6 1.6 1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 4.2 5.0 7.8 2.2 1.6 2.0 2.8 1.5 -2.8 2.5 2.2
Whole body fat mass 2.1 8.7 15.1 0.1 -2.5 -3.6 -3.1 -3.1 3.9 -3.1 -2.4
Leg fat mass (right) 3.4 13.2 19.8 -0.3 -3.3 -4.4 -3.9 -3.9 4.5 -3.9 -3.2
Arm predicted mass (right) 2.8 14.2 28.3 -0.5 -2.7 -5.3 -3.8 -4.1 3.8 -4.4 -3.7
Pulse rate, automated reading 0.4 1.3 3.1 1.6 -1.8 0.0 -0.7 -0.7 1.7 -0.6 -0.6
Alcohol intake frequency. 0.1 0.3 0.8 0.3 0.9 0.0 0.5 0.3 0.6 0.5 0.9
Comparative height size at age 10 0.2 1.1 2.9 0.0 -0.0 -1.7 -0.6 -1.5 1.5 -1.1 -0.4
Number of full sisters 2.7 3.2 5.5 -1.0 -1.4 -2.4 -2.0 -1.9 2.1 -1.9 -1.4
Suffer from ‘nerves’ 5.1 8.0 14.3 1.8 2.6 2.4 3.8 1.9 -3.0 3.3 3.2
Overall health rating 5.1 11.1 16.1 -0.8 -2.6 -3.8 -3.6 -3.4 4.0 -4.0 -3.2
Chest pain or discomfort 0.7 1.0 2.3 0.8 0.9 1.1 1.0 1.1 -1.5 0.7 0.6
Had major operations 0.4 0.5 1.3 -0.6 -0.6 -0.3 -0.7 -1.1 0.2 -0.6 -0.9
Age at last live birth 5.0 7.3 11.5 1.1 2.1 2.9 3.4 2.1 -3.3 3.3 2.6
Family relationship satisfaction 2.5 3.1 5.1 1.8 1.5 1.7 1.8 2.2 -1.1 1.7 1.9
Leg pain on walking 0.5 0.7 1.9 -0.2 -0.1 -0.9 -0.9 0.2 0.3 -1.3 -1.4
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 3.0 1.7 -0.1 0.0 -0.0 -0.3 1.0 0.1 0.3
Commuting to job workplace: Car/motor vehicle 0.3 0.4 0.7 -0.8 -0.7 -0.8 -0.7 -0.1 0.0 -0.8 -0.5
Illness, injury, bereavement, stress in last 2 years 0.4 0.4 0.7 -0.8 -0.8 -0.8 -0.5 -0.2 0.5 -0.8 -0.7
Medication: Aspirin 1.1 1.5 4.3 0.3 -1.3 -0.9 -1.1 -1.4 2.1 -1.1 -0.9
Supplements: Vitamin C 1.6 1.9 3.6 -1.0 -1.2 -0.4 -1.8 -0.6 1.3 -1.9 -1.9
Knee pain experienced in last month 1.1 1.7 3.1 0.2 0.3 -1.6 -1.3 -1.3 1.7 -1.8 -1.3
Hypertension (Self-reported) 5.8 16.2 35.9 -2.0 -2.8 -3.8 -4.7 -3.3 6.0 -4.5 -3.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.4 0.9 -0.9 -0.9 -0.5 -0.6 -0.3 0.2 -0.4 -0.9
Illnesses of father: Heart disease 0.1 0.1 0.5 -0.7 0.2 0.5 -0.1 0.3 -0.2 0.2 0.0
Illnesses of siblings: Diabetes 3.8 4.7 7.8 -2.5 -2.7 -1.7 -2.3 -1.4 -0.2 -2.5 -2.8
Smoking status: Previous 0.6 0.9 3.8 0.4 0.8 2.0 0.3 1.4 -0.4 0.3 -0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.9 3.0 0.6 1.7 -0.2 1.0 -0.1 -0.3 0.9 1.4
Whole body fat-free mass 2.2 12.4 25.3 -0.7 -2.4 -5.0 -3.6 -3.7 3.6 -4.0 -3.4
Leg fat-free mass (right) 2.9 15.7 27.8 -1.0 -2.9 -5.3 -4.3 -4.0 4.2 -4.6 -4.0
Arm fat percentage (left) 2.8 11.1 21.2 -0.4 -2.7 -3.6 -3.7 -3.7 4.6 -3.5 -2.7
Average weekly red wine intake 0.3 0.5 1.8 -0.7 0.2 -0.4 -0.6 0.3 -0.9 -0.4 -1.3
Handedness (chirality/laterality): Left-handed 0.3 0.3 0.7 0.5 -0.5 0.4 -0.2 0.8 -0.5 -0.6 -0.7
Mood swings 4.6 8.3 15.6 2.5 2.2 2.1 3.9 1.6 -2.7 3.5 3.7
Loneliness, isolation 1.5 2.0 3.3 1.8 1.1 1.5 1.7 1.4 -0.7 1.4 1.5
Long-standing illness, disability or infirmity 0.4 0.6 1.6 1.3 1.2 -0.2 -0.2 0.1 1.2 -0.6 0.4
Ever had bowel cancer screening 1.3 1.5 2.4 1.4 0.9 1.5 1.3 0.8 -0.6 1.5 1.4
Diabetes diagnosed by doctor 1.5 2.5 5.9 -0.4 -1.5 -2.4 -1.3 -1.8 1.4 -1.6 -1.6
Ever had stillbirth, spontaneous miscarriage or termination 4.5 4.9 8.6 -1.5 -2.2 -2.8 -2.4 -1.7 0.1 -2.6 -2.9
Friendships satisfaction 0.0 0.0 0.2 0.2 0.1 -0.0 -0.1 0.5 -0.0 -0.1 -0.1
Qualifications: nursing, teaching 0.3 0.4 1.1 -0.2 -0.3 -0.0 0.9 0.6 -1.0 0.9 0.6
Commuting to job workplace: Walk 0.5 0.5 1.6 0.9 1.3 0.1 0.8 -0.6 -0.2 0.8 0.5
Eye problems/disorders: Cataract 0.3 0.4 1.9 -0.4 -1.4 -0.4 -0.2 -0.7 0.4 -0.1 -0.4
Mouth/teeth dental problems: Mouth ulcers 3.1 5.0 7.5 2.4 2.0 2.0 2.7 1.9 -1.7 2.2 2.7
Medication for cholesterol 2.8 4.2 6.9 1.8 1.7 1.8 2.5 0.7 -2.2 2.6 2.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.5 1.8 -0.2 0.1 -0.0 -0.8 -1.3 0.8 -0.7 -0.7
Back pain experienced in last month 0.5 0.8 2.1 0.8 0.8 -0.7 -0.8 -0.8 0.8 -1.4 -0.7
Mineral and other dietary supplements 4.5 6.0 10.9 2.1 1.6 2.0 3.2 1.0 -3.3 2.8 2.7
Breast cancer (self-reported) 0.3 0.3 1.1 1.0 -0.2 -0.3 -0.1 0.4 1.0 -0.4 0.2
Asthma (self-reported) 3.1 6.2 10.9 -1.8 -2.4 -2.2 -3.0 -1.8 3.3 -2.8 -2.3
Osteoporosis (self-reported) 2.9 3.6 6.1 0.7 1.9 2.5 2.2 1.1 -2.2 2.1 1.9
Osteoarthritis (self-reported) 0.6 0.8 2.3 1.5 1.1 -0.9 -0.4 -0.7 1.0 -0.3 -0.5
Medication: Aspirin 0.7 0.9 3.1 0.7 -0.9 -0.5 -0.7 -0.9 1.8 -0.8 -0.7
Medication: Gliclazide 0.2 0.2 0.6 -0.4 -0.7 -0.5 -0.4 -0.8 0.3 -0.1 -0.5
Illnesses of father: None of the above (group 1) 2.9 3.6 5.5 1.9 1.8 1.8 2.4 1.2 -1.8 2.2 1.8
Smoking status: Current 9.5 15.1 20.6 -2.3 -4.2 -4.2 -4.5 -3.4 3.1 -4.5 -4.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.6 3.4 8.7 0.4 1.8 2.1 2.0 1.2 -3.0 1.8 1.5
Whole body water mass 2.2 12.3 25.4 -0.5 -2.4 -5.0 -3.6 -3.7 3.7 -4.0 -3.3
Leg predicted mass (right) 2.9 15.7 27.8 -1.0 -2.9 -5.3 -4.3 -3.9 4.2 -4.6 -4.0
Arm fat mass (left) 3.5 14.2 22.5 -0.3 -3.0 -4.4 -4.2 -4.0 4.7 -4.2 -3.3
Number of self-reported non-cancer illnesses 0.3 0.6 2.1 1.3 0.8 0.3 0.1 -0.2 1.5 0.2 0.6
Average weekly champagne plus white wine intake 0.7 0.9 2.4 -0.1 -0.9 -1.6 -0.7 -1.5 0.5 -0.5 -0.9
Miserableness 9.4 16.3 28.2 3.2 3.1 3.8 5.3 3.5 -3.6 4.7 4.5
Guilty feelings 8.4 12.7 18.9 2.6 3.3 3.4 4.3 2.7 -3.3 4.3 4.2
Wears glasses or contact lenses 0.9 1.0 2.8 1.3 0.5 1.7 0.8 0.7 -0.3 1.2 0.8
Ever taken oral contraceptive pill 1.6 1.8 3.8 1.6 0.4 1.1 1.2 1.9 -0.9 1.6 1.3
Hearing aid user 0.5 0.6 1.0 0.9 1.0 0.7 1.0 0.8 -0.6 0.3 0.8
Mother’s age at death 1.9 2.3 6.8 0.9 0.8 1.1 2.3 -0.5 -0.4 2.6 1.8
Financial situation satisfaction 0.7 0.9 2.8 -0.0 -0.6 -1.7 -1.0 -1.0 0.8 -1.0 -0.6
Tinnitus: Yes, now most or all of the time 1.0 1.2 3.5 -0.1 1.1 1.9 1.2 1.1 -0.9 0.8 0.7
Commuting to job workplace: Public transport 3.7 4.4 7.1 1.1 1.9 2.7 2.6 1.9 -1.9 2.4 2.0
Eye problems/disorders: Glaucoma 3.1 3.7 8.9 -0.6 -1.3 -1.4 -2.4 -1.5 3.0 -2.5 -1.5
Medication: Blood pressure 7.3 13.9 32.1 -2.6 -2.7 -3.2 -4.4 -2.5 5.7 -4.1 -3.5
Pain type(s) experienced in last month: Hip pain 0.6 0.7 4.0 0.2 0.6 -0.3 -0.5 -0.2 2.0 -1.1 0.1
Supplements: Fish oil (including cod liver oil) 3.1 4.1 10.8 -1.2 -1.0 -2.2 -2.5 -0.6 3.3 -2.2 -1.8
High cholesterol (Self-reported) 0.5 0.9 2.9 -0.0 -0.4 -0.9 -0.7 -1.7 1.5 -0.8 -0.5
Medication: Bendroflumethiazide 9.5 14.4 21.0 -3.6 -3.1 -3.8 -4.5 -1.8 3.9 -4.6 -4.3
Medication: Paracetamol 1.1 1.8 4.0 0.3 2.0 1.2 1.5 0.9 -1.2 1.4 1.5
Medication: Lisinopril 0.9 1.1 2.0 -0.6 -0.6 -0.9 -1.4 -0.3 1.3 -1.4 -1.3
Medication: Atorvastatin 0.2 0.3 0.8 -0.4 0.1 -0.4 -0.3 -0.9 0.5 -0.7 -0.5
Illnesses of father: High blood pressure 2.1 2.6 5.0 -0.4 -0.9 -2.1 -1.6 -1.8 2.2 -1.7 -1.1
Alcohol drinker status: Never 0.6 0.7 1.5 0.3 1.2 0.4 0.8 0.8 -0.4 1.2 0.8
Ever smoked 0.2 0.3 0.8 0.8 -0.3 0.2 -0.6 0.2 0.4 -0.9 -0.7
Basal metabolic rate 2.3 12.9 25.2 -0.6 -2.5 -5.0 -3.8 -3.8 3.9 -4.1 -3.4
Leg fat percentage (left) 2.0 7.1 13.7 0.2 -2.7 -2.9 -2.8 -2.8 3.7 -2.7 -2.2
Arm fat-free mass (left) 2.1 10.7 22.2 -0.0 -2.3 -4.7 -3.3 -3.4 3.5 -3.8 -3.1
Number of operations (self-reported) 2.5 3.7 6.8 -0.2 -1.9 -2.0 -2.1 -1.8 2.6 -1.9 -1.9
Average weekly beer plus cider intake 6.7 9.7 13.9 2.2 3.7 3.7 3.2 2.3 -2.4 3.5 3.4
Irritability 13.1 22.2 35.9 2.3 3.6 4.7 5.9 3.8 -6.0 5.5 4.7
Risk taking 8.3 12.1 20.2 -1.4 -3.7 -3.6 -4.0 -3.4 2.1 -4.1 -4.5
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.4 -0.6 0.0 -0.0 0.0 -0.1 -0.6 -0.3 -0.3
Fractured/broken bones in last 5 years 0.7 0.9 2.3 0.6 1.2 1.5 0.6 0.6 -0.8 0.9 0.7
Age started oral contraceptive pill 2.0 2.6 3.5 0.8 1.0 1.6 1.9 1.7 -1.8 1.8 1.9
Diastolic blood pressure, automated reading 8.2 25.3 32.4 -3.2 -3.5 -5.4 -5.6 -5.1 5.7 -5.6 -5.4
Ever depressed for a whole week 5.6 6.9 13.3 1.6 2.2 2.2 2.9 3.6 -2.6 2.9 2.6
Unable to work because of sickness or disability 2.5 3.3 6.4 -1.1 -1.8 -1.8 -2.0 -1.5 1.7 -2.5 -1.8
Commuting to job workplace: Cycle 0.3 0.4 1.2 -1.1 -0.6 -0.3 -0.6 -0.3 0.5 -0.7 -0.6
Myopia 0.3 0.5 1.0 -0.1 1.0 1.0 0.4 0.5 -0.3 0.8 0.9
Vascular/heart problems diagnosed by doctor 3.2 8.7 23.7 0.9 1.4 2.8 3.4 2.6 -4.9 3.3 2.5
Cholesterol lowering medication 0.3 0.5 1.2 -0.5 -0.8 -0.6 -0.8 -0.5 0.1 -0.8 -1.1
Medication: Omeprazole (e.g. Zanprol) 0.2 0.3 0.6 -0.1 -0.7 0.2 -0.5 0.8 0.7 -0.4 -0.3
Pain experienced in last month 0.4 0.7 2.7 -1.3 -1.6 -0.0 -0.4 0.4 -0.8 0.2 -0.3
Supplements: Calcium 0.4 0.4 2.5 -0.7 1.6 0.1 0.4 -0.0 -0.4 0.4 0.0
Basal cell carcinoma (self-reported) 0.3 0.3 1.0 -0.5 -1.0 -0.1 -0.4 -0.6 -0.0 0.0 -0.8
Heart attack/myocardial infarction (self-reported) 0.4 0.5 1.4 1.2 0.9 1.0 0.5 0.3 -0.2 0.4 0.6
Deep venous thrombosis (DVT) (self-reported) 3.1 4.0 6.7 -0.0 -1.5 -2.3 -2.4 -2.0 2.2 -2.6 -1.9
Heart disease (siblings) 0.5 0.6 1.8 1.4 0.4 0.4 0.6 0.0 -0.1 0.8 1.3
Alcohol drinker status: Previous 0.4 0.5 1.1 -0.8 -1.0 -0.1 -0.4 0.7 -0.7 -0.6 -0.8
Pack years of smoking 1.5 2.2 5.4 1.2 -0.9 -2.3 -0.9 -2.0 1.8 -1.3 -0.7
Impedance of whole body 7.1 36.3 50.7 3.1 4.8 6.7 6.9 5.5 -6.5 7.1 6.5
Leg fat mass (left) 3.3 13.0 19.1 -0.3 -3.4 -4.3 -3.9 -3.7 4.4 -3.9 -3.3
Arm predicted mass (left) 2.2 11.1 22.8 0.0 -2.2 -4.8 -3.4 -3.4 3.6 -3.9 -3.1