TWAS hub - SCG3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Lung Adenocarcinoma	0.0623	0.0338	0.00025	0.019	0.025	0.023	NA	0.018	0.0024	0.00053	0.00083	NA	0.0033
2	TCGA	Thyroid Carcinoma	0.1600	0.0990	0.00360	0.010	0.017	0.010	NA	0.002	0.0320	0.00850	0.03000	NA	0.2000

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Number of incorrect matches in round	10.5	17.5	18.2	4.1	4.3
Frequency of tiredness / lethargy in last 2 weeks	9.7	15.8	19.8	-4.5	-3.4
Verbal and Numeric Reasoning (VNR)	6.1	14.6	27.3	-5.2	-1.4
Body Mass Index (BMI) (2010)	5.7	7.9	11.6	-3.4	-2.0
Intelligence (Savage-Jansen 2018)	5.6	17.3	30.8	-5.6	-1.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	5.2	6.2	8.6	1.9	2.9
Forced expiratory volume in 1-second (FEV1), Best measure	5.0	16.0	22.2	-3.1	-4.7
Neck or shoulder pain in last month	5.0	7.1	7.9	2.5	2.8
Had major operations	4.8	5.7	6.3	2.5	2.3
Had menopause	4.7	5.8	11.3	0.6	3.4
BMI	4.4	25.3	38.1	-6.2	-3.5
Waist circumference	4.3	15.7	20.3	-4.5	-3.3
Arm fat percentage (right)	4.3	16.9	24.9	-5.0	-3.0
Forced vital capacity (FVC), Best measure	4.2	15.4	22.0	-3.0	-4.7
Trunk fat percentage	4.1	16.5	22.8	-4.8	-3.2
Trunk fat mass	4.1	17.8	22.6	-4.8	-3.6
Arm fat mass (right)	4.1	16.9	22.3	-4.7	-3.4
Body fat percentage	4.1	16.1	22.6	-4.8	-3.1
Whole body fat mass	4.0	16.5	21.5	-4.6	-3.4
Arm fat mass (left)	4.0	16.4	20.6	-4.5	-3.5
Medication: Ventolin 100micrograms inhaler	3.9	5.0	5.5	-2.3	-2.1
Arm fat percentage (left)	3.9	15.7	22.2	-4.7	-3.0
Type 2 Diabetes (T2D) (2018)	3.8	7.1	10.7	-3.3	-1.9
Ever taken oral contraceptive pill	3.8	4.2	4.4	-2.0	-2.1
Leg fat mass (left)	3.8	14.9	19.8	-4.5	-3.2
Forced expiratory volume in 1-second (FEV1)	3.6	12.1	17.6	-2.6	-4.2
Ever used hormone-replacement therapy (HRT)	3.5	4.5	8.4	0.8	2.9
Mouth/teeth dental problems: Bleeding gums	3.5	4.5	5.6	-2.4	-1.9
Leg fat mass (right)	3.5	13.7	18.2	-4.3	-3.0
Hearing aid user	3.5	4.0	4.9	1.7	2.2
Schizophrenia vs Biploar Disorder	3.4	4.5	5.2	2.3	2.0
Leg fat percentage (left)	3.4	12.2	17.7	-4.2	-2.6
Weight	3.3	16.1	18.4	-4.3	-3.7
Happiness	3.3	4.0	4.1	-2.0	-2.0
Hip circumference	3.2	14.0	16.1	-4.0	-3.4
Qualifications: College or University degree	3.2	10.2	13.0	-3.6	-2.7
Current tobacco smoking	3.1	5.0	7.2	1.7	2.7
Mother’s age at death	3.1	3.9	4.5	1.8	2.1
Fasting Glucose	3.0	3.6	4.4	-2.1	-1.6
Fed-up feelings	3.0	5.4	5.9	-2.2	-2.4
Forced vital capacity (FVC)	3.0	11.4	17.7	-2.3	-4.2
Fluid intelligence score	2.9	6.1	10.2	-3.2	-1.4
Comparative body size at age 10	2.9	8.0	10.0	-3.2	-2.5
Number of full sisters	2.9	3.5	5.2	-1.4	-2.3
Body mass index (BMI)	2.8	11.9	16.4	-4.0	-2.7
Father’s age at death	2.8	3.8	6.9	-2.6	0.8
Diverticular disease/diverticulitis (self-reported)	2.7	3.2	4.6	-1.3	-2.1
Seen doctor (GP) for nerves, anxiety, tension or depression	2.6	3.9	4.9	-1.7	-2.2
Illnesses of siblings: Diabetes	2.6	3.2	5.3	-2.3	-1.1
Ever had bowel cancer screening	2.6	3.1	5.3	0.9	2.3
Medication: Cholesterol lowering	2.5	3.9	5.1	2.3	1.7
Peak expiratory flow (PEF)	2.5	5.9	9.2	-1.6	-3.0
Leg fat percentage (right)	2.5	8.9	13.3	-3.6	-2.1
Heel bone mineral density (BMD) T-score, automated (left)	2.4	5.4	10.2	-3.2	0.8
Breast Cancer	2.3	5.5	5.9	-2.3	-2.4
Neuroticism (2016)	2.3	3.3	3.5	-1.9	-1.8
Bilateral oophorectomy (both ovaries removed)	2.3	2.6	3.3	1.4	1.8
Number of full brothers	2.3	2.9	4.7	-1.1	-2.2
Smoking status: Current	2.2	3.5	6.0	1.0	2.4
Severe depression (siblings)	2.1	2.3	2.7	-1.6	-1.4
Number of live births	2.1	3.0	5.4	0.8	2.3
Leg fat-free mass (right)	2.1	11.1	12.2	-3.5	-3.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.1	2.5	3.1	1.4	1.8
Basal metabolic rate	2.1	11.5	12.4	-3.2	-3.5
Average weekly beer plus cider intake	2.1	3.1	4.4	-1.3	-2.1
Wheeze or whistling in the chest in last year	2.0	3.5	5.2	-2.3	-1.4
Leg predicted mass (right)	2.0	10.6	11.6	-3.4	-3.1
Medication: Co-codamol	1.9	2.2	3.1	1.8	1.2
Prospective memory result	1.9	2.3	3.4	1.1	1.8
Financial situation satisfaction	1.9	2.3	4.7	-0.1	2.2
Hand grip strength (left)	1.8	4.6	7.7	-1.2	-2.8
Heel bone mineral density (BMD) T-score, automated (right)	1.8	4.1	6.3	-2.5	1.4
Time employed in main current job	1.8	2.1	3.5	1.9	0.8
Exposure to tobacco smoke at home	1.8	2.0	2.7	-1.6	-1.2
Alzheimer’s Disease (including proxy)	1.7	2.5	4.2	-2.1	-0.9
Supplements: Zinc	1.7	1.9	2.3	-1.2	-1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.2	2.8	-1.3	-1.7
Health satisfaction	1.7	2.2	2.6	-1.6	-1.3
Overall health rating	1.7	3.6	5.4	-2.3	-1.3
Family relationship satisfaction	1.7	2.0	3.9	-2.0	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	1.7	3.6	7.0	-0.5	-2.6
Diabetes diagnosed by doctor	1.7	2.9	5.1	-2.3	-0.8
Supplements: Calcium	1.7	1.9	2.9	0.9	1.7
Heart disease (siblings)	1.7	2.1	2.9	-1.2	-1.7
Lupus	1.6	2.4	2.7	1.5	1.6
Smoking Status	1.6	3.8	4.1	1.9	2.0
Sensitivity / hurt feelings	1.6	2.7	5.1	2.2	-0.5
Leg fat-free mass (left)	1.6	8.6	9.3	-3.0	-2.8
Hand grip strength (right)	1.6	4.4	6.7	-1.5	-2.6
Leg predicted mass (left)	1.6	8.6	9.3	-3.0	-2.8
Number of children fathered	1.6	1.9	2.6	1.6	1.0
Basal cell carcinoma (self-reported)	1.6	1.9	2.0	1.4	1.4
Qualifications: None of the above	1.5	3.3	4.9	1.3	2.2
Commuting to job workplace: Public transport	1.5	1.8	3.1	-1.8	-0.8
Arm fat-free mass (left)	1.5	7.8	8.8	-2.6	-3.0
Blood White Count	1.4	10.3	14.7	-3.8	-2.4
Angina	1.4	1.8	2.8	1.7	0.9
Hearing difficulty/problems with background noise	1.4	2.3	2.8	1.3	1.7
Illnesses of siblings	1.4	1.9	3.0	0.9	1.7
Mouth/teeth dental problems: Dentures	1.4	2.4	2.7	1.6	1.5
Whole body fat-free mass	1.4	8.0	9.7	-2.5	-3.1
Friendships satisfaction	1.4	1.7	2.3	-1.5	-1.0
Wears glasses or contact lenses	1.4	1.6	2.8	-1.7	-0.7
Age started oral contraceptive pill	1.4	1.8	2.7	0.9	1.6
Number of treatments/medications taken	1.3	2.3	3.3	1.1	1.8
Birth weight of first child	1.3	2.4	2.6	-1.6	-1.5
Arm predicted mass (right)	1.3	6.7	9.4	-2.0	-3.1
Chest pain or discomfort	1.3	1.9	3.6	-1.9	-0.4
Whole body water mass	1.3	7.7	9.3	-2.5	-3.0
Arm predicted mass (left)	1.3	6.8	7.2	-2.5	-2.7
Alzheimer’s Disease (in father)	1.2	1.3	2.2	-1.5	-0.6
Crohns Disease (2012)	1.2	1.9	3.7	-1.9	0.2
Relative age voice broke	1.2	1.9	2.1	1.4	1.3
Qualifications: CSEs or equivalent	1.2	1.6	2.6	0.8	-1.6
Noisy workplace	1.2	1.5	2.4	-1.6	-0.8
Arm fat-free mass (right)	1.2	6.2	8.5	-2.0	-2.9
Breast cancer (self-reported)	1.2	1.4	2.4	1.5	0.6
Schizophrenia (2018)	1.1	2.2	3.3	1.1	1.8
Systolic Blood Pressure	1.1	5.3	8.7	-1.4	-3.0
Trunk fat-free mass	1.1	6.5	9.4	-1.9	-3.1
Trunk predicted mass	1.1	6.2	9.3	-1.8	-3.0
Headache pain in last month	1.1	1.9	2.0	-1.4	-1.4
Qualifications: nursing, teaching	1.1	1.8	3.5	-0.1	-1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.3	3.7	-1.0	-1.9
HbA1C	1.0	1.1	2.0	-0.4	-1.4
Schizophrenia (2014)	1.0	2.1	2.3	1.4	1.5
Heel T-Score	1.0	8.0	10.6	-3.3	2.3
Taking other prescription medications	1.0	1.6	2.2	1.0	1.5
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	2.3	-0.8	-1.5
Had other major operations	1.0	1.2	1.5	-1.2	-1.0
Diabetes (self-reported)	1.0	1.6	2.0	-1.4	-1.1
Age at first live birth	1.0	1.8	2.5	1.6	1.0
Supplements: Vitamin C	1.0	1.2	1.9	-1.4	-0.7
Loneliness, isolation	1.0	1.4	2.5	-1.6	-0.4
Chronotype (morning person)	0.9	2.1	3.7	-1.9	-0.8
Relative age of first facial hair	0.9	1.8	3.5	1.9	0.1
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	2.3	-1.5	-0.3
Length of working week for main job	0.9	1.0	1.3	1.1	0.8
Birth weight	0.9	2.0	2.9	-1.7	-1.0
Angina (self-reported)	0.9	1.2	1.9	1.4	0.7
Mean time to correctly identify matches	0.9	1.7	2.8	0.8	1.7
Illnesses of father: Heart disease	0.9	1.2	2.2	0.5	-1.5
Back pain experienced in last month	0.9	1.3	2.6	1.6	0.3
High cholesterol (Self-reported)	0.9	1.5	2.8	1.7	0.6
Mean Putamen Volume	0.8	1.0	1.0	-1.0	0.9
Ulcerative Colitis	0.8	1.1	1.8	-0.6	1.3
Blood Eosinophil Count	0.8	5.9	10.6	-3.3	-1.1
Lung FVC	0.8	3.9	4.8	-1.7	-2.2
Heart attack	0.8	1.0	1.3	1.2	0.8
Qualifications: A levels/AS levels or equivalent	0.8	1.7	2.3	-1.0	-1.5
Illnesses of mother	0.8	1.0	1.6	1.2	-0.6
Gout (self-reported)	0.8	1.1	2.2	0.2	1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	2.2	1.5	-0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	1.0	-1.0	-1.0
Osteoarthritis (self-reported)	0.8	1.1	1.5	-1.2	-0.8
Irritability	0.8	1.4	1.4	1.2	-1.1
Commuting to job workplace: Cycle	0.8	0.9	1.8	-0.0	-1.4
Crohns Disease (2017)	0.7	1.6	2.6	-1.6	-0.8
Ulcerative Colitis (UC)	0.7	1.3	2.5	0.0	1.6
Triglycerides	0.7	1.1	1.4	-1.0	-1.2
Falls in the last year	0.7	1.0	2.0	1.4	0.3
Medication: Seretide 50 evohaler	0.7	0.9	1.0	1.0	0.8
Osteoporosis (self-reported)	0.7	0.9	1.0	1.0	0.9
Illnesses of father: None of the above (group 1)	0.7	0.9	1.0	0.9	1.0
Pain type(s) experienced in last month: Hip pain	0.7	0.8	1.0	0.8	1.0
Ever had prostate specific antigen (PSA) test	0.7	0.9	1.0	0.9	1.0
Cholesterol lowering medication	0.7	1.0	1.8	0.3	1.4
Coronary Artery Disease (CAD)	0.6	0.7	1.2	1.1	0.4
Lung FEV1/FVC ratio	0.6	2.8	3.9	-2.0	-1.3
Average weekly spirits intake	0.6	0.7	1.0	0.7	1.0
Ever had hysterectomy (womb removed)	0.6	0.7	0.8	-0.7	0.9
Maternal smoking around birth	0.6	0.8	1.6	-1.3	-0.1
Stomach or abdominal pain in last month	0.6	0.8	1.4	-1.2	-0.4
Pulse rate	0.6	1.0	1.7	0.6	1.3
Asthma	0.6	1.2	1.7	-1.3	-0.8
Breastfed as a baby	0.6	0.8	1.2	-0.6	1.1
Pulse wave reflection index	0.6	0.8	1.1	-1.1	-0.6
Emphysema/chronic bronchitis	0.6	0.7	1.2	-1.1	0.4
Medication: Omeprazole	0.6	0.7	1.2	1.1	0.4
Leg pain on walking	0.6	0.7	1.2	-0.5	1.1
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	1.1	1.0	0.7
Medication: Aspirin	0.6	0.8	0.8	0.9	0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	1.0	0.6	1.0
Supplements: Fish oil (including cod liver oil)	0.6	0.8	0.9	0.9	0.9
Medication: Atorvastatin	0.6	0.8	0.8	0.9	0.9
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.1	1.1	0.7
Bipolar Disorder or Schizophrenia	0.5	1.1	1.3	1.0	1.1
Bipolar Disorder (2011)	0.5	0.5	1.0	0.1	1.0
Allergy or Eczema	0.5	1.4	1.6	1.1	1.3
Cardiovascular Disease	0.5	1.8	2.7	-1.0	-1.6
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.2	-0.5	-1.1
Medication: Metformin	0.5	0.7	1.2	-1.1	0.4
Medication: Levothyroxine sodium	0.5	0.8	0.9	0.9	1.0
Alcohol usually taken with meals	0.5	0.8	1.6	-0.2	1.3
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	0.9	-0.9	-0.8
Medication for pain relief, constipation, heartburn	0.5	0.9	1.0	-0.9	-1.0
Average weekly red wine intake	0.5	0.7	1.1	0.5	1.0
Mineral and other dietary supplements	0.5	0.7	1.4	-0.3	-1.2
Medication: Aspirin	0.5	0.6	0.8	0.7	0.9
Medication: Gliclazide	0.5	0.5	0.7	0.5	0.9
Number of self-reported non-cancer illnesses	0.5	0.9	1.8	0.2	1.4
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	0.8	0.9	0.7
Rheumatoid Arthritis	0.4	0.6	0.7	0.8	0.7
Type 2 Diabetes (T2D) (2012)	0.4	0.5	0.6	-0.6	-0.8
Vitamin and mineral supplements	0.4	0.5	0.6	0.8	-0.6
Diabetes (father)	0.4	0.6	0.8	-0.6	-0.9
Sitting height	0.4	2.6	4.9	2.2	-0.5
High blood pressure (mother)	0.4	0.5	0.7	-0.9	0.6
Hair/balding pattern: Pattern 2	0.4	0.5	0.5	-0.7	-0.7
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	0.8	0.4	0.9
Medication: Simvastatin	0.4	0.6	0.7	0.7	0.8
Medication: Lansoprazole	0.4	0.4	0.7	0.8	0.4
Standing height	0.4	3.6	6.6	-0.8	-2.6
Medication: Paracetamol	0.4	0.6	1.2	-0.2	-1.1
High blood pressure (siblings)	0.4	0.5	1.0	0.1	-1.0
Medication: Allopurinol	0.4	0.6	1.1	0.2	1.1
Suffer from ‘nerves’	0.4	0.6	1.2	-1.1	-0.2
Age at last live birth	0.4	0.5	0.9	0.4	0.9
Knee pain experienced in last month	0.4	0.6	0.9	-0.9	0.6
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.1	1.1	-0.3
Asthma (self-reported)	0.4	0.9	1.2	-1.1	-0.7
Medication: Blood pressure	0.4	0.7	0.7	-0.8	-0.8
Alcohol drinker status: Never	0.4	0.5	0.7	-0.5	-0.9
Number of operations (self-reported)	0.4	0.6	1.2	0.2	1.1
Risk taking	0.4	0.5	0.9	0.4	1.0
Fractured/broken bones in last 5 years	0.4	0.5	0.6	0.8	0.7
Diastolic blood pressure, automated reading	0.4	1.2	1.4	-1.0	-1.2
Worry (Nagel 2018)	0.3	0.7	0.8	0.8	0.9
Irritable Bowel Disease (IBD)	0.3	0.8	1.4	-1.2	0.4
Prostate Cancer	0.3	0.4	0.9	0.1	0.9
Respiratory disease	0.3	0.8	1.5	-1.2	0.2
Impedance of leg (right)	0.3	1.5	2.7	1.6	0.6
Medication: Atenolol	0.3	0.4	0.6	0.3	0.8
Chronic bronchitis/emphysema (father)	0.3	0.4	0.4	-0.6	-0.6
Tense / ‘highly strung’	0.3	0.4	0.8	0.9	-0.2
Exposure to tobacco smoke outside home	0.3	0.4	0.7	0.9	-0.1
Worry too long after embarrassment	0.3	0.5	0.9	-0.9	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.5	0.4	-0.7
Pulse wave peak to peak time	0.3	0.4	0.6	-0.8	-0.4
Shortness of breath walking on level ground	0.3	0.3	0.6	0.1	0.8
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.6	-0.2	0.8
Medication: Blood pressure	0.3	0.6	0.8	0.6	0.9
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	0.4	0.6	0.6
Medication for cholesterol	0.3	0.4	0.8	-0.0	-0.9
Average weekly champagne plus white wine intake	0.3	0.4	0.6	-0.8	-0.4
Medication: Bendroflumethiazide	0.3	0.4	0.8	0.0	0.9
Alcohol drinker status: Previous	0.3	0.3	0.6	0.0	0.8
Alzheimer’s Disease (in mother)	0.2	0.2	0.2	-0.4	-0.5
Primary Biliary Cirrhosis	0.2	0.3	0.5	0.1	0.7
Blood Platelet Count	0.2	2.6	3.5	-1.9	-1.3
Blood Red Count	0.2	1.7	3.3	-0.3	-1.8
Tanning	0.2	2.8	4.1	2.0	1.2
Hearing difficulty/problems: Yes	0.2	0.3	0.6	-0.8	0.1
Diabetes (mother)	0.2	0.3	0.4	-0.6	0.3
Average weekly fortified wine intake	0.2	0.2	0.4	0.0	0.7
Serious illness, injury or assault to yourself	0.2	0.2	0.3	0.5	-0.4
Financial difficulties in last 2 years	0.2	0.2	0.5	0.1	0.7
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.6	-0.7	-0.2
Alcohol intake versus 10 years previously	0.2	0.3	0.5	0.0	-0.7
Depression (self-reported)	0.2	0.3	0.4	-0.6	-0.3
Loud music exposure frequency	0.2	0.2	0.4	0.2	0.7
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	0.8	0.9	-0.0
Glaucoma (self-reported)	0.2	0.3	0.6	0.1	-0.7
Migraine (self-reported)	0.2	0.2	0.3	-0.3	-0.5
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.5	-0.1	-0.7
Long-standing illness, disability or infirmity	0.2	0.3	0.4	0.3	-0.7
Commuting to job workplace: Walk	0.2	0.2	0.3	0.6	0.4
Eye problems/disorders: Cataract	0.2	0.2	0.2	-0.5	-0.5
Miserableness	0.2	0.3	0.4	0.6	-0.5
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.4	0.2	0.6
Eye problems/disorders: Glaucoma	0.2	0.2	0.3	0.6	-0.4
Medication: Lisinopril	0.2	0.3	0.6	0.8	0.0
Unable to work because of sickness or disability	0.2	0.3	0.4	0.6	0.4
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.5	0.7	0.1
Depressed Affect (Nagel 2018)	0.1	0.3	0.4	-0.6	-0.5
Depression (Nagel 2018)	0.1	0.2	0.3	-0.6	-0.3
Neuroticism (Nagel 2018)	0.1	0.2	0.4	0.6	-0.1
Major Depression (MDD)	0.1	0.1	0.2	-0.3	0.4
Reaction Time	0.1	0.2	0.2	0.5	0.4
Ovarian Cancer	0.1	0.2	0.2	0.4	0.4
Age at First Birth	0.1	0.1	0.2	0.5	0.1
LDL Cholesterol	0.1	0.2	0.4	-0.1	-0.6
Height	0.1	2.7	5.3	-0.0	-2.3
Waist Hip Ratio (WHR)	0.1	0.5	0.9	0.0	-1.0
Neuroticism	0.1	0.2	0.3	0.1	-0.5
Systolic blood pressure, automated reading	0.1	0.2	0.5	-0.1	-0.7
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	-0.2	0.4
Medication for hormone replacement therapy	0.1	0.1	0.1	-0.3	0.2
Age when periods started (menarche)	0.1	0.3	0.4	0.6	0.4
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	0.5	0.1
High blood pressure	0.1	0.3	0.5	-0.5	-0.7
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.5	0.2	0.7
Multivitamins +/- minerals	0.1	0.1	0.1	0.3	0.2
Supplements: Glucosamine	0.1	0.2	0.3	-0.5	0.3
Impedance of leg (left)	0.1	0.4	0.8	0.9	0.0
Nervous feelings	0.1	0.2	0.3	0.6	0.3
Allergy	0.1	0.1	0.2	-0.2	-0.5
Pain all over the body in last month	0.1	0.1	0.1	-0.1	-0.4
Neuroticism score	0.1	0.3	0.4	0.4	-0.7
Worrier / anxious feelings	0.1	0.2	0.3	0.5	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.1	0.4	-0.4
Pulse wave Arterial Stiffness index	0.1	0.2	0.3	0.5	0.1
Blood clot in the leg (DVT)	0.1	0.2	0.2	0.4	0.4
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.2	-0.4	0.2
Chronic bronchitis/emphysema (mother)	0.1	0.2	0.3	0.2	0.5
Eye problems/disorders: None of the above	0.1	0.1	0.1	-0.2	-0.3
Heart disease (mother)	0.1	0.2	0.2	-0.3	0.5
Pulse rate, automated reading	0.1	0.3	0.6	-0.8	0.1
Comparative height size at age 10	0.1	0.3	0.6	-0.3	0.8
Hypertension (Self-reported)	0.1	0.2	0.3	-0.3	-0.5
Smoking status: Previous	0.1	0.2	0.4	0.6	0.2
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.1	0.3	-0.4
Mood swings	0.1	0.3	0.3	0.5	-0.5
Guilty feelings	0.1	0.2	0.2	0.3	0.5
Medication: Paracetamol	0.1	0.2	0.3	-0.6	-0.4
Illnesses of father: High blood pressure	0.1	0.1	0.2	0.2	-0.5
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.4	0.6	0.4
Pack years of smoking	0.1	0.1	0.1	0.3	0.4
Impedance of whole body	0.1	0.8	1.2	1.1	0.6
Bipolar Disorder (2018)	0.0	0.1	0.1	-0.0	-0.4
HDL Cholesterol	0.0	0.0	0.1	-0.3	0.1
Hypothyroidism (self reported)	0.0	0.0	0.1	-0.3	-0.0
Hair Pigment	0.0	0.4	0.4	0.6	0.7
Pack years adult smoking proportion	0.0	0.0	0.0	0.1	0.0
Townsend deprivation index at recruitment	0.0	0.0	0.0	-0.2	0.2
Past tobacco smoking	0.0	0.0	0.1	-0.0	-0.3
Mouth/teeth dental problems	0.0	0.0	0.0	-0.0	0.0
Medication: Ramipril	0.0	0.0	0.0	-0.1	-0.2
Impedance of arm (right)	0.0	0.2	0.3	-0.0	0.6
Hair/balding pattern: Pattern 3	0.0	0.0	0.0	-0.1	0.1
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.0	0.1	-0.3	0.1
Lung cancer (father)	0.0	0.1	0.1	0.0	0.3
Impedance of arm (left)	0.0	0.2	0.3	0.6	0.3
Hair/balding pattern: Pattern 4	0.0	0.1	0.2	-0.4	0.0
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.1	0.3	0.2
Medication: Amlodipine	0.0	0.0	0.0	-0.1	-0.2
Medication: Ibuprofen	0.0	0.0	0.1	-0.3	-0.1
Alcohol intake frequency.	0.0	0.1	0.1	-0.2	-0.3
Ever smoked	0.0	0.0	0.1	-0.3	0.1
Ever depressed for a whole week	0.0	0.0	0.0	0.2	-0.1
Myopia	0.0	0.0	0.0	0.2	-0.2
Pain experienced in last month	0.0	0.0	0.0	-0.1	-0.2

Hub : Genes

SCG3

Models

Trait associations