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chr10:103,313,599-105,850,787

Best TWAS P=1.04e-17 · Best GWAS P=2.98e-19 conditioned to 0.00772

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Visceral Omentum	SFXN2	0.25	0.16	enet	20	0.18	8.8e-10	-4.9	6.0	2.7e-09	-0.53	0.94	0.02	FALSE
2	GTEx	Artery Aorta	ARL3	0.19	0.07	lasso	6	0.06	4.8e-04	-3.8	5.2	2.3e-07	-0.71	0.31	0.48	FALSE
3	GTEx	Breast Mammary Tissue	SFXN2	0.11	0.00	enet	12	0.03	1.3e-02	-3.2	5.2	2.2e-07	-0.39	0.19	0.04	FALSE
4	GTEx	Breast Mammary Tissue (Female)	SFXN2	0.09	-0.01	enet	7	0.01	1.9e-01	-5.2	6.1	1.1e-09	-0.50	0.05	0.05	FALSE
5	GTEx	Breast Mammary Tissue (Female)	CYP17A1-AS1	0.14	0.01	lasso	11	0.00	4.7e-01	-7.5	-5.6	2.6e-08	0.87	0.03	0.60	FALSE
6	GTEx	Cells Transformed fibroblasts	GBF1	0.07	0.00	enet	2	0.00	1.4e-01	-5.9	-6.0	2.6e-09	0.78	0.04	0.48	FALSE
7	GTEx	Cells Transformed fibroblasts	SUFU	0.07	0.04	lasso	3	0.04	3.5e-04	-7.3	-7.5	9.4e-14	0.83	0.39	0.14	FALSE
8	GTEx	Skin Sun Exposed Lower leg	SFXN2	0.08	0.07	lasso	5	0.05	2.6e-05	-4.9	5.2	1.6e-07	-0.48	0.53	0.09	FALSE
9	GTEx	Stomach	SFXN2	0.22	0.09	lasso	5	0.08	1.8e-04	-4.9	5.2	2.0e-07	-0.54	0.78	0.02	FALSE
10	GTEx	Testis	NT5C2	0.20	0.03	lasso	8	0.08	2.8e-04	-7.3	-7.3	2.9e-13	0.86	0.05	0.91	FALSE
11	GTEx	Testis	CYP17A1-AS1	0.14	0.08	enet	5	0.10	2.3e-05	-7.4	7.6	4.1e-14	-0.97	0.05	0.93	FALSE
12	GTEx	Thyroid	WBP1L	0.26	0.10	enet	9	0.13	2.1e-10	-4.9	6.8	7.9e-12	-0.80	0.66	0.34	FALSE
13	METSIM	Adipose	SFXN2	0.16	0.09	lasso	4	0.08	1.4e-12	-4.9	5.2	2.2e-07	-0.48	1.00	0.00	FALSE
14	ROSMAP	Brain Pre-frontal Cortex	CNNM2	0.11	0.08	lasso	3	0.07	2.2e-09	-8.1	-8.1	4.8e-16	0.99	0.02	0.98	FALSE
15	ROSMAP	Brain Pre-frontal Cortex	USMG5	0.04	0.03	lasso	9	0.03	1.6e-04	-3.1	5.9	4.4e-09	-0.64	0.04	0.94	FALSE
16	YFS	Blood	NT5C2	0.13	0.10	bslmm	382	0.11	7.3e-35	-8.8	-8.6	1.0e-17	0.94	0.01	0.99	TRUE
17	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	SFXN2	0.18	0.13	enet	8	0.15	7.0e-13	-4.9	5.7	1.4e-08	-0.55	0.92	0.08	FALSE
18	The Cancer Genome Atlas	Breast Invasive Carcinoma	SFXN2	0.12	0.09	lasso	4	0.10	4.4e-19	-5.2	5.3	1.2e-07	-0.56	0.90	0.10	FALSE
19	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	ARL3	0.09	0.02	blup	57	0.05	1.8e-03	-3.8	5.7	1.6e-08	-0.58	0.01	0.59	FALSE
20	The Cancer Genome Atlas	Colon Adenocarcinoma	SFXN2	0.11	0.05	blup	47	0.05	7.2e-04	-4.9	6.3	3.4e-10	-0.63	0.12	0.65	FALSE
21	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SFXN2	0.20	0.15	lasso	4	0.18	9.5e-20	-5.2	5.5	3.4e-08	-0.54	0.91	0.09	FALSE
22	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SFXN2	0.16	0.11	enet	6	0.12	6.4e-13	-5.2	5.6	1.9e-08	-0.56	0.89	0.11	FALSE
23	The Cancer Genome Atlas	Brain Lower Grade Glioma	ARL3	0.04	0.00	blup	57	0.04	1.5e-05	-3.8	5.2	2.0e-07	-0.49	0.05	0.76	FALSE
24	The Cancer Genome Atlas	Brain Lower Grade Glioma	SFXN2	0.12	0.07	lasso	6	0.07	2.0e-08	-4.9	5.2	1.5e-07	-0.53	0.97	0.03	FALSE
25	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	SFXN2	0.20	0.08	blup	48	0.13	9.3e-07	-5.2	5.3	1.2e-07	-0.46	0.03	0.96	FALSE
26	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ARL3	0.04	0.00	blup	57	0.02	3.1e-03	-3.8	5.2	1.7e-07	-0.53	0.04	0.68	FALSE
27	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SFXN2	0.39	0.16	lasso	6	0.15	2.3e-10	-4.9	5.2	1.9e-07	-0.50	0.90	0.10	FALSE
28	The Cancer Genome Atlas	Soft Tissue Sarcoma	SFXN2	0.23	0.10	lasso	6	0.16	6.2e-10	3.1	5.7	1.1e-08	-0.54	0.44	0.52	FALSE
29	The Cancer Genome Atlas	Stomach Adenocarcinoma	AS3MT	0.05	0.02	blup	62	0.03	2.1e-03	3.1	-6.7	1.8e-11	0.72	0.03	0.32	FALSE
30	The Cancer Genome Atlas	Stomach Adenocarcinoma	SFXN2	0.15	0.10	enet	9	0.11	2.4e-08	-4.9	5.4	7.7e-08	-0.53	0.24	0.76	FALSE
31	The Cancer Genome Atlas	Testicular Germ Cell Tumors	SFXN2	0.33	0.26	enet	6	0.29	1.0e-10	-4.9	5.5	4.4e-08	-0.57	0.75	0.25	FALSE