[Hub]/) : Traits : Cardiovascular Disease :

chr10:103,313,599-105,850,787

Best TWAS P=1.04e-17 · Best GWAS P=2.98e-19 conditioned to 0.00772

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Visceral Omentum SFXN2 0.25 0.16 enet 20 0.18 8.8e-10 -4.9 6.0 2.7e-09 -0.53 0.94 0.02 FALSE
2 GTEx Artery Aorta ARL3 0.19 0.07 lasso 6 0.06 4.8e-04 -3.8 5.2 2.3e-07 -0.71 0.31 0.48 FALSE
3 GTEx Breast Mammary Tissue SFXN2 0.11 0.00 enet 12 0.03 1.3e-02 -3.2 5.2 2.2e-07 -0.39 0.19 0.04 FALSE
4 GTEx Breast Mammary Tissue (Female) SFXN2 0.09 -0.01 enet 7 0.01 1.9e-01 -5.2 6.1 1.1e-09 -0.50 0.05 0.05 FALSE
5 GTEx Breast Mammary Tissue (Female) CYP17A1-AS1 0.14 0.01 lasso 11 0.00 4.7e-01 -7.5 -5.6 2.6e-08 0.87 0.03 0.60 FALSE
6 GTEx Cells Transformed fibroblasts GBF1 0.07 0.00 enet 2 0.00 1.4e-01 -5.9 -6.0 2.6e-09 0.78 0.04 0.48 FALSE
7 GTEx Cells Transformed fibroblasts SUFU 0.07 0.04 lasso 3 0.04 3.5e-04 -7.3 -7.5 9.4e-14 0.83 0.39 0.14 FALSE
8 GTEx Skin Sun Exposed Lower leg SFXN2 0.08 0.07 lasso 5 0.05 2.6e-05 -4.9 5.2 1.6e-07 -0.48 0.53 0.09 FALSE
9 GTEx Stomach SFXN2 0.22 0.09 lasso 5 0.08 1.8e-04 -4.9 5.2 2.0e-07 -0.54 0.78 0.02 FALSE
10 GTEx Testis NT5C2 0.20 0.03 lasso 8 0.08 2.8e-04 -7.3 -7.3 2.9e-13 0.86 0.05 0.91 FALSE
11 GTEx Testis CYP17A1-AS1 0.14 0.08 enet 5 0.10 2.3e-05 -7.4 7.6 4.1e-14 -0.97 0.05 0.93 FALSE
12 GTEx Thyroid WBP1L 0.26 0.10 enet 9 0.13 2.1e-10 -4.9 6.8 7.9e-12 -0.80 0.66 0.34 FALSE
13 METSIM Adipose SFXN2 0.16 0.09 lasso 4 0.08 1.4e-12 -4.9 5.2 2.2e-07 -0.48 1.00 0.00 FALSE
14 ROSMAP Brain Pre-frontal Cortex CNNM2 0.11 0.08 lasso 3 0.07 2.2e-09 -8.1 -8.1 4.8e-16 0.99 0.02 0.98 FALSE
15 ROSMAP Brain Pre-frontal Cortex USMG5 0.04 0.03 lasso 9 0.03 1.6e-04 -3.1 5.9 4.4e-09 -0.64 0.04 0.94 FALSE
16 YFS Blood NT5C2 0.13 0.10 bslmm 382 0.11 7.3e-35 -8.8 -8.6 1.0e-17 0.94 0.01 0.99 TRUE
17 The Cancer Genome Atlas Bladder Urothelial Carcinoma SFXN2 0.18 0.13 enet 8 0.15 7.0e-13 -4.9 5.7 1.4e-08 -0.55 0.92 0.08 FALSE
18 The Cancer Genome Atlas Breast Invasive Carcinoma SFXN2 0.12 0.09 lasso 4 0.10 4.4e-19 -5.2 5.3 1.2e-07 -0.56 0.90 0.10 FALSE
19 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma ARL3 0.09 0.02 blup 57 0.05 1.8e-03 -3.8 5.7 1.6e-08 -0.58 0.01 0.59 FALSE
20 The Cancer Genome Atlas Colon Adenocarcinoma SFXN2 0.11 0.05 blup 47 0.05 7.2e-04 -4.9 6.3 3.4e-10 -0.63 0.12 0.65 FALSE
21 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma SFXN2 0.20 0.15 lasso 4 0.18 9.5e-20 -5.2 5.5 3.4e-08 -0.54 0.91 0.09 FALSE
22 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma SFXN2 0.16 0.11 enet 6 0.12 6.4e-13 -5.2 5.6 1.9e-08 -0.56 0.89 0.11 FALSE
23 The Cancer Genome Atlas Brain Lower Grade Glioma ARL3 0.04 0.00 blup 57 0.04 1.5e-05 -3.8 5.2 2.0e-07 -0.49 0.05 0.76 FALSE
24 The Cancer Genome Atlas Brain Lower Grade Glioma SFXN2 0.12 0.07 lasso 6 0.07 2.0e-08 -4.9 5.2 1.5e-07 -0.53 0.97 0.03 FALSE
25 The Cancer Genome Atlas Liver Hepatocellular Carcinoma SFXN2 0.20 0.08 blup 48 0.13 9.3e-07 -5.2 5.3 1.2e-07 -0.46 0.03 0.96 FALSE
26 The Cancer Genome Atlas Lung Squamous Cell Carcinoma ARL3 0.04 0.00 blup 57 0.02 3.1e-03 -3.8 5.2 1.7e-07 -0.53 0.04 0.68 FALSE
27 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma SFXN2 0.39 0.16 lasso 6 0.15 2.3e-10 -4.9 5.2 1.9e-07 -0.50 0.90 0.10 FALSE
28 The Cancer Genome Atlas Soft Tissue Sarcoma SFXN2 0.23 0.10 lasso 6 0.16 6.2e-10 3.1 5.7 1.1e-08 -0.54 0.44 0.52 FALSE
29 The Cancer Genome Atlas Stomach Adenocarcinoma AS3MT 0.05 0.02 blup 62 0.03 2.1e-03 3.1 -6.7 1.8e-11 0.72 0.03 0.32 FALSE
30 The Cancer Genome Atlas Stomach Adenocarcinoma SFXN2 0.15 0.10 enet 9 0.11 2.4e-08 -4.9 5.4 7.7e-08 -0.53 0.24 0.76 FALSE
31 The Cancer Genome Atlas Testicular Germ Cell Tumors SFXN2 0.33 0.26 enet 6 0.29 1.0e-10 -4.9 5.5 4.4e-08 -0.57 0.75 0.25 FALSE