Hub : Genes

MUC6

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.046	0.0173	0.0010	-0.001	0.011	-0.001	NA	-0.001	0.5400	0.00680	0.41000	NA	0.52000
2	TCGA	Skin Cutaneous Melanoma	0.260	0.1040	0.0049	0.004	0.027	0.031	NA	0.019	0.2400	0.06300	0.05100	NA	0.09800
3	TCGA	Thyroid Carcinoma	0.077	0.0420	0.0002	0.022	0.034	0.020	NA	0.028	0.0031	0.00025	0.00410	NA	0.00093
4	TCGA	Uterine Corpus Endometrial Carcinoma	0.510	0.1350	0.0071	0.065	-0.008	0.132	NA	0.179	0.0070	0.60000	0.00016	NA	0.00001

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	2.3	3.7	12.9	0.2	0.3	-1.4	3.6
Bipolar Disorder or Schizophrenia	0.4	1.0	1.5	-0.9	-0.8	-1.2	1.1
Depressed Affect (Nagel 2018)	0.6	1.3	4.9	-0.3	2.2	0.2	-0.4
Depression (Nagel 2018)	0.6	0.9	2.7	0.1	1.7	-0.6	0.8
Intelligence (Savage-Jansen 2018)	1.0	3.2	10.2	0.3	0.8	3.2	1.3
Neuroticism (Nagel 2018)	1.1	2.6	8.1	0.7	2.9	1.2	0.5
Schizophrenia (2018)	0.7	1.5	2.3	-1.3	-1.3	-0.5	-1.5
Schizophrenia vs Biploar Disorder	2.2	2.8	8.0	0.4	-0.1	1.8	-2.8
Worry (Nagel 2018)	1.5	3.1	6.5	1.3	2.6	0.8	1.9
Alzheimer’s Disease (in mother)	0.5	0.5	1.2	-0.2	-0.9	0.2	1.1
Alzheimer’s Disease (in father)	1.0	1.1	1.7	0.6	-1.0	-1.3	1.2
Alzheimer’s Disease (including proxy)	1.2	1.8	2.7	-0.9	-1.2	-1.6	1.5
Crohns Disease (2017)	1.6	3.6	9.2	-3.0	-1.8	-1.3	0.4
Irritable Bowel Disease (IBD)	1.8	4.2	10.3	-3.2	-2.5	-0.6	0.3
Ulcerative Colitis (UC)	1.2	2.2	5.7	-1.7	-2.4	0.2	-0.5
Major Depression (MDD)	0.0	0.0	0.2	0.0	0.0	-0.4	0.0
Reaction Time	1.0	1.8	4.5	-2.1	-0.6	-1.1	-1.1
Verbal and Numeric Reasoning (VNR)	1.1	2.6	8.8	-0.0	0.7	3.0	1.1
Breast Cancer	0.7	1.6	3.6	1.5	-0.8	1.9	0.4
Ovarian Cancer	0.3	0.3	0.9	-0.9	0.5	0.5	-0.1
Prostate Cancer	1.1	1.5	4.9	0.5	-0.5	2.2	0.8
Age at First Birth	1.1	1.7	3.5	0.4	1.9	1.7	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	4.2	5.7	10.1	-3.2	-2.3	-0.4	-2.7
Coronary Artery Disease (CAD)	0.6	0.7	1.2	0.0	1.0	0.7	-1.1
Crohns Disease (2012)	1.6	2.6	5.0	-2.2	-1.8	-1.4	-0.0
Mean Putamen Volume	2.5	2.8	7.1	-0.6	-1.6	-2.7	1.1
Fasting Glucose	3.7	4.4	13.8	-3.7	-0.6	-1.7	-0.8
HbA1C	2.2	2.4	4.7	-2.2	1.9	-1.1	-0.3
HDL Cholesterol	2.1	3.5	7.3	2.2	1.4	-0.1	2.7
LDL Cholesterol	1.2	1.9	4.2	0.1	0.7	1.7	-2.1
Lupus	3.0	4.6	15.1	-3.9	-1.5	0.8	0.4
Neuroticism (2016)	0.6	0.9	1.6	1.3	0.6	-1.2	0.0
Primary Biliary Cirrhosis	0.5	0.8	2.2	-1.5	0.1	0.8	0.4
Rheumatoid Arthritis	1.6	2.1	2.6	-1.4	-1.5	-1.3	-1.6
Schizophrenia (2014)	0.2	0.4	0.8	0.6	-0.6	0.3	-0.9
Triglycerides	0.5	0.8	1.1	-0.9	0.3	1.1	-1.1
Type 2 Diabetes (T2D) (2012)	0.7	0.8	2.1	-1.4	0.6	0.8	0.5
Ulcerative Colitis	0.4	0.6	1.6	-0.6	-1.3	0.3	-0.5
Blood Eosinophil Count	0.2	1.8	7.1	-0.1	-0.0	0.4	-2.7
Blood Platelet Count	0.4	4.4	11.8	-3.4	-0.5	-2.3	-0.4
Blood Red Count	0.1	0.9	2.2	0.4	1.5	0.3	-0.9
Blood White Count	0.1	1.1	3.0	-1.7	0.6	-0.3	-0.8
Heel T-Score	0.2	1.8	5.8	0.2	1.1	-2.4	-0.0
BMI	1.6	9.5	22.7	-4.8	0.4	-3.6	1.4
Height	0.5	8.9	27.7	-1.7	-5.3	2.1	0.8
Waist Hip Ratio (WHR)	0.1	0.4	1.5	-1.2	0.0	0.5	-0.0
Systolic Blood Pressure	0.3	1.7	6.4	-0.2	-0.1	-2.5	0.5
Smoking Status	0.2	0.4	0.8	0.9	0.5	-0.0	0.8
Allergy or Eczema	0.8	2.1	3.7	-1.6	-0.4	-1.9	-1.4
Cardiovascular Disease	0.4	1.3	2.7	-0.8	1.3	-1.6	-0.4
Hypothyroidism (self reported)	2.3	5.2	10.8	-3.0	-0.2	0.9	-3.3
Respiratory disease	1.0	2.3	5.5	1.6	2.3	0.1	-1.1
Type 2 Diabetes (T2D) (2018)	0.7	1.4	4.0	0.4	1.0	2.0	-0.6
Lung FEV1/FVC ratio	1.1	5.7	17.6	-1.7	-1.1	-4.2	-1.0
Lung FVC	0.5	2.4	6.4	1.2	-0.2	2.5	-1.3
Neuroticism	1.5	3.6	13.0	0.8	3.6	0.7	0.6
Chronotype (morning person)	0.9	2.0	6.2	-0.4	-1.2	-2.5	0.5
Hair Pigment	0.0	1.0	2.2	-1.5	0.6	-0.1	1.2
Tanning	0.2	2.0	3.3	1.3	-0.1	1.7	1.8
Hand grip strength (left)	1.4	3.7	12.2	-1.3	-3.5	0.8	0.2
Number of treatments/medications taken	1.0	1.8	6.2	-2.5	-0.2	-1.0	-0.3
Average weekly spirits intake	2.1	2.7	6.3	-1.5	1.2	-0.8	2.5
Sensitivity / hurt feelings	1.1	1.9	5.8	0.4	2.4	1.4	0.0
Frequency of depressed mood in last 2 weeks	0.5	0.7	2.4	-0.0	1.5	-0.6	0.4
Hearing difficulty/problems: Yes	1.6	2.5	7.7	-2.8	0.0	-1.0	1.0
Relative age of first facial hair	0.7	1.5	5.7	0.0	-0.1	-0.6	2.4
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.1	-1.0	-0.9	-0.9	-1.0
Ever used hormone-replacement therapy (HRT)	0.7	0.9	1.6	1.3	0.0	1.2	0.7
Ever had hysterectomy (womb removed)	1.2	1.4	2.5	-0.4	-1.3	-1.6	1.1
Systolic blood pressure, automated reading	1.1	3.3	6.8	-1.6	-1.0	-2.6	1.7
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	2.6	-0.5	-1.6	1.1	0.8
Angina	0.7	0.9	1.7	-1.3	0.1	0.9	-1.1
Medication for hormone replacement therapy	0.6	0.7	1.3	1.1	0.6	-0.0	1.1
Vitamin and mineral supplements	0.5	0.7	1.8	0.5	1.3	0.8	-0.3
Supplements: Zinc	0.4	0.5	1.0	1.0	-0.2	-0.8	-0.4
Medication: Co-codamol	0.4	0.5	1.1	-0.8	-0.0	-1.0	-0.4
Medication: Metformin	0.2	0.2	0.3	0.6	-0.2	0.6	-0.5
Diabetes (father)	1.2	1.4	4.4	1.0	0.3	2.1	0.5
Diabetes (mother)	0.6	0.7	2.2	-0.6	0.5	0.3	-1.5
Severe depression (siblings)	0.8	0.9	2.5	0.4	0.6	-0.7	1.6
Pack years adult smoking proportion	1.0	1.6	4.0	-1.3	2.0	0.3	-0.8
Impedance of leg (right)	0.9	4.5	10.3	2.3	1.1	3.2	-1.1
Leg fat-free mass (left)	1.3	6.9	10.8	-3.3	-3.3	-2.4	0.6
Trunk fat percentage	0.8	3.0	7.0	-2.6	-1.1	-1.8	0.7
Hand grip strength (right)	1.3	3.5	12.2	-1.0	-3.5	0.9	-0.0
Townsend deprivation index at recruitment	0.2	0.3	1.0	0.2	0.4	-0.3	-1.0
Current tobacco smoking	0.4	0.7	1.8	0.9	-0.2	0.5	-1.3
Average weekly fortified wine intake	0.5	0.6	1.1	1.0	-0.3	-0.5	1.0
Maternal smoking around birth	0.7	1.0	2.6	1.2	1.6	0.1	-0.4
Fed-up feelings	0.1	0.3	0.4	-0.6	0.5	0.3	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.5	-0.7	0.4	-0.1	0.2
Relative age voice broke	1.5	2.3	7.3	1.0	0.3	-0.8	2.7
Taking other prescription medications	0.7	1.2	4.3	-2.1	-0.1	-0.5	0.2
Age when periods started (menarche)	1.1	2.6	4.8	1.9	0.7	2.2	1.2
Bilateral oophorectomy (both ovaries removed)	1.2	1.3	3.0	-1.0	-0.7	-0.9	1.7
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.1	0.3	-0.1	-0.1	-0.6	0.1
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.4	0.5	-0.2	0.6	-0.5
Qualifications: CSEs or equivalent	0.7	0.9	2.4	0.4	1.5	-1.0	-0.3
Serious illness, injury or assault to yourself	0.3	0.3	0.8	-0.4	-0.1	0.9	-0.6
High blood pressure	0.2	0.6	1.3	-0.0	-0.5	-0.8	1.2
Hayfever, allergic rhinitis or eczema	0.6	1.4	3.7	-1.2	-0.2	-1.9	-0.3
Multivitamins +/- minerals	0.3	0.4	1.1	-0.4	-1.0	-0.5	0.2
Stomach or abdominal pain in last month	2.4	2.9	7.2	1.2	2.7	1.7	0.4
Supplements: Glucosamine	0.3	0.4	1.3	-0.2	0.1	-0.4	1.2
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	2.2	-0.1	-0.6	0.1	1.5
Medication: Atenolol	1.3	1.6	4.4	-2.1	-0.7	-0.2	-1.1
Medication: Levothyroxine sodium	1.1	1.8	3.8	-1.9	-0.2	0.0	-1.8
Sitting height	0.4	2.8	6.9	-2.6	-2.0	0.5	-0.2
Chronic bronchitis/emphysema (father)	0.6	0.8	2.0	-1.4	-0.2	0.2	1.0
High blood pressure (mother)	0.8	1.2	3.1	-1.2	0.3	-1.8	0.1
Body mass index (BMI)	1.2	5.3	11.8	-3.4	-0.2	-2.9	1.1
Impedance of leg (left)	0.9	4.5	11.1	2.1	0.9	3.3	-1.2
Leg predicted mass (left)	1.3	6.9	10.9	-3.3	-3.2	-2.4	0.6
Trunk fat mass	1.0	4.5	10.1	-3.2	-1.8	-1.9	0.9
Waist circumference	1.1	3.9	10.0	-3.2	-0.5	-1.8	1.4
Number of incorrect matches in round	0.8	1.3	4.1	0.5	-2.0	-0.8	-0.0
Past tobacco smoking	1.1	2.0	6.8	0.3	-0.4	0.9	-2.6
Alcohol usually taken with meals	3.1	5.0	15.8	0.1	-4.0	1.9	0.6
Nervous feelings	0.9	1.7	4.6	1.0	2.1	-0.1	1.1
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.3	8.4	0.3	2.9	-0.3	0.9
Hearing difficulty/problems with background noise	1.8	2.9	4.6	-2.1	-1.4	-2.1	-0.8
Hair/balding pattern: Pattern 2	0.8	1.0	3.9	-2.0	-0.1	-0.4	-0.3
Had menopause	0.4	0.5	1.9	0.1	-1.4	0.3	-0.3
Had other major operations	0.7	0.9	2.4	-1.6	0.8	-0.7	-0.2
Forced vital capacity (FVC)	0.2	0.7	2.3	-0.0	-0.5	1.5	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.0	0.0	-0.1	0.0	-0.1	0.1
Ever unenthusiastic/disinterested for a whole week	1.9	2.3	4.4	-1.9	-1.0	-2.1	0.4
Qualifications: None of the above	0.4	0.8	2.3	-1.5	-0.7	-0.5	0.1
Financial difficulties in last 2 years	1.6	2.1	5.0	-0.0	2.2	-1.8	-0.1
Mouth/teeth dental problems	0.6	0.9	2.1	1.4	-0.7	0.9	0.4
Heart attack	0.1	0.1	0.2	-0.4	0.5	-0.3	-0.3
Allergy	0.5	1.2	3.2	1.3	0.3	1.8	0.3
Pain all over the body in last month	1.1	1.2	1.6	-1.2	-1.3	-1.3	0.2
Diabetes (self-reported)	1.2	1.9	4.8	0.7	1.4	2.2	0.4
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.4	-0.6	0.2	-0.4	0.5
Medication: Ramipril	0.3	0.4	1.1	-0.0	-0.0	-1.0	0.6
Medication: Simvastatin	0.5	0.7	2.1	-0.6	0.5	-1.5	-0.1
Fluid intelligence score	0.9	1.9	4.9	-0.7	0.9	2.2	1.3
Illnesses of siblings	0.6	0.8	1.3	0.7	1.1	0.7	1.1
Neuroticism score	1.0	2.1	7.7	0.0	2.8	0.7	0.4
Weight	1.3	6.6	14.4	-3.8	-2.3	-2.4	1.1
Impedance of arm (right)	0.4	1.8	3.8	1.9	-0.6	1.4	-1.0
Arm fat percentage (right)	1.0	4.0	8.6	-2.9	-0.8	-2.6	0.5
Trunk fat-free mass	1.1	6.3	11.7	-3.2	-3.4	-1.5	1.0
Hip circumference	1.3	5.7	10.7	-3.3	-1.8	-2.7	1.3
Time employed in main current job	0.8	0.9	2.1	1.1	-0.2	1.5	-0.4
Alcohol intake versus 10 years previously	1.2	1.8	4.8	0.4	1.0	-2.2	1.2
Father’s age at death	0.6	0.8	1.3	1.1	0.1	0.8	-1.0
Worrier / anxious feelings	1.7	3.2	6.8	1.7	2.6	1.2	1.3
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.4	-0.7	0.8	0.9	-1.2
Falls in the last year	0.8	1.1	2.0	-1.3	0.2	-1.4	-0.7
Hair/balding pattern: Pattern 3	2.5	3.7	8.2	2.9	1.7	1.0	-1.7
Number of live births	1.1	1.5	3.5	1.9	-1.1	0.1	-1.2
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	0.6	-0.4	-0.8	0.2	-0.6
Pulse rate	0.5	0.8	1.7	-0.6	-1.3	-0.9	0.7
Happiness	3.2	3.9	8.8	-3.0	-1.6	-1.9	0.7
Noisy workplace	0.3	0.4	0.9	0.1	-0.7	-0.9	-0.4
Qualifications: A levels/AS levels or equivalent	0.8	1.7	3.3	1.8	-0.1	1.6	0.9
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.7	3.3	0.9	1.2	-1.8	-1.1
Mouth/teeth dental problems: Dentures	1.0	1.7	3.6	-1.9	-1.4	-0.5	-1.0
Asthma	0.6	1.1	3.6	-0.3	0.8	-1.9	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	0.6	-0.7	-0.6	-0.8	0.7
Medication: Cholesterol lowering	0.4	0.6	1.0	0.7	1.0	-0.4	-0.7
Depression (self-reported)	0.7	0.9	1.9	0.8	0.5	0.8	1.4
Medication: Lansoprazole	1.6	1.8	5.4	-2.3	0.8	-0.2	-1.1
Prospective memory result	1.2	1.5	2.7	-1.0	-1.6	-1.0	-1.2
Lung cancer (father)	3.4	4.0	11.0	3.3	-0.0	1.7	1.5
Illnesses of mother	1.1	1.3	2.1	0.9	-1.3	1.5	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.0	0.1	0.0	-0.4	0.1	-0.2
Pulse wave Arterial Stiffness index	2.9	3.4	4.3	2.0	2.1	2.1	1.1
Impedance of arm (left)	0.8	3.6	9.4	3.1	-0.1	2.0	-0.9
Arm fat mass (right)	1.4	5.8	12.0	-3.5	-1.5	-2.8	1.2
Trunk predicted mass	1.1	6.3	11.4	-3.2	-3.4	-1.5	0.9
Standing height	0.5	5.1	18.4	-1.2	-4.3	0.8	0.1
Length of working week for main job	1.5	1.7	4.6	-0.3	1.2	0.8	-2.1
Exposure to tobacco smoke at home	1.6	1.8	4.7	-2.2	-0.3	-1.6	-0.3
Breastfed as a baby	1.0	1.2	4.0	0.3	-2.0	0.8	-0.2
Tense / ‘highly strung’	0.2	0.4	0.8	0.7	-0.1	-0.4	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.6	-0.3	-0.3	-0.4	0.8
Hair/balding pattern: Pattern 4	0.5	1.1	2.2	-0.9	-1.5	0.7	1.1
Birth weight of first child	1.1	1.9	2.6	-1.6	-1.6	-0.6	1.5
Peak expiratory flow (PEF)	0.3	0.8	1.7	-1.3	-0.9	-0.6	-0.4
Pulse wave reflection index	2.7	3.3	6.5	1.8	2.6	1.9	-0.3
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.5	-0.7	-0.1	-0.7	0.4
Loud music exposure frequency	2.1	2.3	5.2	-2.3	-1.1	-0.9	1.3
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.4	0.4	0.5	-0.5	0.6
Mouth/teeth dental problems: Bleeding gums	0.0	0.0	0.0	-0.1	0.2	-0.1	0.1
Blood clot in the leg (DVT)	0.6	0.7	2.5	-0.2	0.3	0.5	1.6
Medication: Paracetamol	0.5	0.9	1.8	0.9	1.4	-0.4	0.8
Headache pain in last month	0.1	0.1	0.2	0.2	0.3	0.4	-0.4
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.5	-0.5	-0.6	-0.2	-0.7
Glaucoma (self-reported)	0.1	0.2	0.5	-0.1	-0.4	0.7	-0.2
Gout (self-reported)	1.0	1.4	3.4	1.1	1.9	-0.7	0.7
Hypothyroidism/myxoedema (self-reported)	1.4	2.7	6.3	-2.5	0.0	0.6	-2.1
Medication: Amlodipine	0.7	1.0	1.4	0.9	1.0	1.0	1.2
Medication: Ventolin 100micrograms inhaler	1.6	2.1	6.7	-0.9	0.8	-2.6	-0.2
Birth weight	0.4	0.8	1.9	-0.2	-1.4	0.4	1.1
Chronic bronchitis/emphysema (mother)	1.0	1.2	4.0	-0.3	2.0	-0.3	0.8
High blood pressure (siblings)	0.2	0.3	1.1	-0.4	0.2	-1.0	0.1
Forced vital capacity (FVC), Best measure	0.2	0.6	1.9	0.0	0.0	1.4	-0.6
Body fat percentage	0.7	2.7	7.0	-2.6	-0.7	-1.8	0.4
Leg fat percentage (right)	0.6	2.0	5.8	-2.4	-0.1	-1.4	0.4
Arm fat-free mass (right)	1.0	5.1	10.3	-3.2	-2.6	-1.4	1.0
Exposure to tobacco smoke outside home	3.0	4.0	6.7	-1.7	0.7	-2.6	-2.4
Comparative body size at age 10	1.8	4.8	7.2	-2.2	-2.7	-2.1	-1.7
Number of full brothers	0.3	0.4	1.5	0.2	0.1	-1.2	-0.1
Worry too long after embarrassment	3.5	6.0	13.2	1.0	2.7	3.6	1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	3.2	0.7	0.5	1.8	-0.6
Wheeze or whistling in the chest in last year	1.1	1.9	3.6	-0.8	1.9	-1.5	-1.0
Number of children fathered	2.7	3.0	4.5	-2.1	-1.9	-1.5	-1.4
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.7	4.6	0.1	-1.5	-0.4	2.1
Age at first live birth	0.5	0.9	3.0	0.4	0.5	1.7	0.0
Pulse wave peak to peak time	3.6	4.2	6.5	-2.2	-2.6	-2.0	-1.3
Health satisfaction	1.5	2.0	4.6	-2.1	1.7	0.2	-0.7
Shortness of breath walking on level ground	0.9	1.1	3.1	-1.8	0.8	0.7	-0.2
Qualifications: College or University degree	0.9	3.0	5.6	1.2	2.1	2.4	0.6
Eye problems/disorders: None of the above	1.1	1.2	3.8	0.2	0.8	-1.9	0.6
Mouth/teeth dental problems: Loose teeth	2.4	2.8	7.4	-0.1	2.7	-0.6	-1.9
Emphysema/chronic bronchitis	1.6	1.8	4.0	0.8	-0.2	2.0	-1.6
Medication for pain relief, constipation, heartburn	0.5	0.8	2.8	0.3	0.4	1.7	-0.4
Neck or shoulder pain in last month	0.1	0.2	0.4	0.2	0.5	-0.4	0.6
Medication: Blood pressure	0.5	0.9	2.0	0.5	0.0	1.2	1.4
Angina (self-reported)	0.7	0.9	1.6	-1.0	0.5	1.3	-0.8
Migraine (self-reported)	2.1	2.6	6.4	-1.4	-1.5	-2.5	0.3
Medication: Ibuprofen	0.3	0.4	1.5	-0.4	-0.2	-1.2	0.1
Medication: Allopurinol	0.6	0.8	2.4	0.7	1.6	-0.5	0.2
Medication: Omeprazole	0.7	0.9	1.4	-0.7	1.2	-0.5	1.1
Medication: Seretide 50 evohaler	1.6	1.8	5.6	-0.2	1.2	2.4	0.2
Mean time to correctly identify matches	0.6	1.2	2.6	-1.6	-0.5	-1.4	-0.3
Heart disease (mother)	1.1	1.4	1.9	1.0	1.3	0.9	-1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.8	5.1	-1.4	-0.3	-2.3	-0.4
Whole body fat mass	1.1	4.7	10.4	-3.2	-1.6	-2.2	0.9
Leg fat mass (right)	1.1	4.1	10.4	-3.2	-1.4	-1.9	0.6
Arm predicted mass (right)	1.0	5.2	10.6	-3.2	-2.7	-1.3	1.1
Pulse rate, automated reading	0.3	1.1	2.2	-1.4	0.0	-0.1	1.5
Alcohol intake frequency.	0.3	0.8	1.8	-0.7	0.4	-0.8	-1.3
Comparative height size at age 10	0.6	3.4	9.4	-1.6	-3.1	-0.4	1.2
Number of full sisters	0.6	0.7	1.6	0.4	1.0	-0.3	-1.3
Suffer from ‘nerves’	2.1	3.4	6.5	1.1	1.8	1.6	2.5
Overall health rating	0.6	1.2	1.9	-1.4	1.4	0.3	-1.0
Chest pain or discomfort	1.0	1.4	4.7	0.5	2.2	0.6	-0.5
Had major operations	0.1	0.1	0.2	0.1	0.2	-0.2	-0.5
Age at last live birth	0.6	0.9	1.9	1.4	0.5	1.1	-0.1
Family relationship satisfaction	1.7	2.1	5.5	-1.3	0.1	-1.1	2.4
Leg pain on walking	0.4	0.5	1.1	-0.6	-1.1	-0.4	0.7
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.4	2.6	-1.1	-0.9	-1.6	-1.0
Commuting to job workplace: Car/motor vehicle	0.8	0.9	3.3	0.2	1.8	0.1	-0.3
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.1	0.3	-1.1	0.6	-0.2
Medication: Aspirin	1.0	1.3	1.9	-1.4	-0.9	-1.4	0.7
Supplements: Vitamin C	0.7	0.8	2.7	0.5	-0.4	-1.6	0.5
Knee pain experienced in last month	1.4	2.1	5.2	-1.8	-0.1	-2.3	0.4
Hypertension (Self-reported)	0.3	0.8	2.6	-0.2	-0.1	-0.8	1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.4	2.8	7.3	1.0	2.7	0.6	1.6
Illnesses of father: Heart disease	0.6	0.8	1.9	1.1	0.0	-0.2	-1.4
Illnesses of siblings: Diabetes	0.3	0.3	0.8	-0.3	-0.9	-0.3	-0.6
Smoking status: Previous	1.1	1.7	4.9	-0.1	0.7	-1.1	2.2
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.9	3.4	-1.8	-1.6	-1.2	-0.3
Whole body fat-free mass	1.2	6.9	11.8	-3.4	-3.4	-1.9	0.9
Leg fat-free mass (right)	1.2	6.5	11.0	-3.1	-3.3	-2.2	0.5
Arm fat percentage (left)	0.8	3.0	5.8	-2.4	-0.7	-2.4	0.5
Average weekly red wine intake	2.5	3.8	9.8	-0.3	-3.1	-1.4	1.8
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.8	0.9	-0.9	-0.2	0.2
Mood swings	0.6	1.0	2.4	-0.2	1.3	-0.3	-1.6
Loneliness, isolation	0.5	0.7	2.4	-0.4	1.6	-0.4	-0.2
Long-standing illness, disability or infirmity	0.9	1.3	3.7	-1.9	0.8	-0.9	-0.4
Ever had bowel cancer screening	0.1	0.2	0.3	-0.1	-0.6	0.5	-0.2
Diabetes diagnosed by doctor	0.5	0.8	1.9	0.2	1.0	1.4	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.4	1.0	-1.0	0.5	0.3	0.1
Friendships satisfaction	3.2	4.0	11.6	-3.4	-0.8	-1.9	-0.1
Qualifications: nursing, teaching	0.9	1.3	4.0	0.4	0.6	2.0	0.9
Commuting to job workplace: Walk	0.4	0.5	1.1	-0.3	-0.5	-0.7	1.0
Eye problems/disorders: Cataract	0.4	0.4	1.4	-0.2	0.2	1.2	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.6	1.0	1.3	0.6	0.6
Medication for cholesterol	0.6	0.9	2.8	0.8	-0.2	1.7	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.8	-0.9	-0.3	0.4	-0.1
Back pain experienced in last month	0.6	0.9	2.0	1.4	-0.9	0.9	-0.3
Mineral and other dietary supplements	2.0	2.7	6.1	1.0	1.2	2.5	-1.5
Breast cancer (self-reported)	0.6	0.7	2.4	-0.6	0.1	1.5	-0.3
Asthma (self-reported)	0.4	0.8	2.5	-0.3	0.8	-1.6	0.2
Osteoporosis (self-reported)	0.1	0.1	0.3	0.0	0.5	-0.2	0.0
Osteoarthritis (self-reported)	1.9	2.4	6.9	-1.3	-0.3	-2.6	1.0
Medication: Aspirin	0.4	0.5	0.7	-0.6	-0.9	-0.8	0.5
Medication: Gliclazide	0.4	0.5	0.9	-0.4	0.0	0.9	0.9
Illnesses of father: None of the above (group 1)	0.4	0.5	1.1	0.2	0.7	0.4	1.1
Smoking status: Current	0.5	0.8	2.3	0.7	-0.4	0.4	-1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.1	0.9	0.1	1.1	0.4
Whole body water mass	1.2	6.6	11.2	-3.4	-3.3	-1.9	0.7
Leg predicted mass (right)	1.2	6.5	11.4	-3.1	-3.4	-2.1	0.4
Arm fat mass (left)	1.1	4.5	10.7	-3.3	-1.1	-2.4	0.9
Number of self-reported non-cancer illnesses	0.1	0.2	0.6	0.1	0.5	-0.4	0.8
Average weekly champagne plus white wine intake	0.7	0.9	2.5	-0.7	-0.8	1.6	-0.5
Miserableness	0.1	0.1	0.5	0.1	0.2	0.0	-0.7
Guilty feelings	0.4	0.6	1.8	-1.3	0.4	-0.7	-0.2
Wears glasses or contact lenses	0.8	0.9	3.2	-0.3	0.5	1.8	0.0
Ever taken oral contraceptive pill	0.7	0.8	1.5	-0.9	0.8	-1.2	-0.2
Hearing aid user	0.9	1.1	2.1	-1.5	-0.5	-1.2	-0.7
Mother’s age at death	0.4	0.5	1.6	-0.1	-1.3	-0.4	0.3
Financial situation satisfaction	2.0	2.5	5.9	-2.4	0.8	-1.8	-0.6
Tinnitus: Yes, now most or all of the time	0.8	0.9	2.9	-0.6	-1.7	0.5	-0.5
Commuting to job workplace: Public transport	0.7	0.8	2.0	0.5	0.9	-0.4	1.4
Eye problems/disorders: Glaucoma	0.4	0.4	1.2	0.4	-0.2	1.1	-0.5
Medication: Blood pressure	1.4	2.7	4.6	-1.7	-1.6	-2.2	0.8
Pain type(s) experienced in last month: Hip pain	1.1	1.4	1.9	1.4	0.7	-1.2	1.3
Supplements: Fish oil (including cod liver oil)	1.4	1.8	4.7	-0.6	-1.2	-2.2	0.7
High cholesterol (Self-reported)	0.9	1.6	3.7	-0.4	1.3	-0.9	-1.9
Medication: Bendroflumethiazide	0.5	0.8	1.5	-1.2	-1.2	-0.4	0.3
Medication: Paracetamol	0.6	0.9	2.4	0.7	1.5	0.2	0.8
Medication: Lisinopril	0.9	1.2	1.8	-1.3	-1.1	-1.3	-0.2
Medication: Atorvastatin	0.9	1.2	2.7	-0.4	1.7	1.2	-0.6
Illnesses of father: High blood pressure	0.3	0.3	1.0	1.0	0.5	-0.3	-0.1
Alcohol drinker status: Never	1.0	1.2	2.1	1.4	1.0	1.2	-0.5
Ever smoked	1.1	2.0	6.0	0.5	1.1	-0.8	2.5
Basal metabolic rate	1.3	7.0	12.5	-3.5	-3.2	-2.1	0.8
Leg fat percentage (left)	0.6	2.2	6.9	-2.6	-0.1	-1.3	0.4
Arm fat-free mass (left)	1.4	7.1	15.6	-4.0	-2.9	-1.9	1.1
Number of operations (self-reported)	1.1	1.7	5.6	0.6	2.4	0.8	-0.3
Average weekly beer plus cider intake	1.0	1.4	3.0	0.9	1.3	-0.4	-1.7
Irritability	0.1	0.1	0.3	-0.1	0.3	0.5	0.4
Risk taking	1.0	1.5	5.5	0.4	0.2	0.3	-2.3
Ever had prostate specific antigen (PSA) test	0.5	0.5	1.0	-1.0	-1.0	-0.4	0.2
Fractured/broken bones in last 5 years	0.5	0.7	2.5	-0.4	-0.2	-0.2	1.6
Age started oral contraceptive pill	0.7	0.8	1.4	1.1	-0.9	-1.2	0.2
Diastolic blood pressure, automated reading	0.5	1.6	4.3	0.6	0.6	-1.2	2.1
Ever depressed for a whole week	1.5	1.9	4.0	-1.3	-0.2	-1.3	2.0
Unable to work because of sickness or disability	1.9	2.5	7.6	-2.8	0.7	-1.3	0.3
Commuting to job workplace: Cycle	0.4	0.5	1.0	1.0	-0.6	0.6	0.4
Myopia	0.3	0.4	0.7	-0.7	0.6	-0.8	-0.5
Vascular/heart problems diagnosed by doctor	0.2	0.4	0.7	0.2	0.8	0.7	-0.8
Cholesterol lowering medication	1.0	1.4	3.0	-1.7	0.7	-0.8	-1.3
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	3.8	0.2	2.0	-0.0	0.3
Pain experienced in last month	0.4	0.7	2.0	0.3	1.4	0.6	-0.7
Supplements: Calcium	1.0	1.1	2.5	1.2	-0.2	-0.7	1.6
Basal cell carcinoma (self-reported)	0.9	1.1	3.0	0.9	-0.8	0.2	1.7
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.2	-0.3	0.5	-0.2	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	3.3	-0.1	0.3	0.5	1.8
Heart disease (siblings)	3.0	3.7	9.2	0.5	-3.0	-0.1	-2.4
Alcohol drinker status: Previous	0.1	0.2	0.3	0.5	0.5	0.3	0.0
Pack years of smoking	1.0	1.5	2.9	-1.4	1.7	1.0	-0.3
Impedance of whole body	0.8	4.2	7.9	2.7	0.5	2.8	-1.0
Leg fat mass (left)	1.1	4.1	10.9	-3.3	-1.4	-1.8	0.7
Arm predicted mass (left)	1.4	7.0	14.2	-3.8	-3.0	-2.0	1.1