TWAS hub - MOB2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Colon Sigmoid	0.4210	0.0880	1.3e-06	0.234	NA	0.227	NA	0.206	8.3e-09	NA	1.5e-08	NA	8.2e-08
2	GTEx	Esophagus Muscularis	0.2000	0.0560	7.2e-05	0.114	NA	0.077	NA	0.126	2.0e-07	NA	2.1e-05	NA	4.8e-08
3	TCGA	Esophageal Carcinoma	0.1610	0.1150	7.4e-03	0.055	0.025	0.018	NA	0.031	7.9e-03	5.6e-02	8.6e-02	NA	3.5e-02
4	TCGA	Lung Adenocarcinoma	0.0229	0.0143	2.5e-03	0.014	0.018	0.014	NA	0.017	7.5e-03	2.9e-03	7.6e-03	NA	4.1e-03
5	TCGA	Prostate Adenocarcinoma	0.0784	0.0315	2.1e-10	0.051	0.101	0.097	NA	0.098	4.3e-06	1.1e-10	2.6e-10	NA	1.9e-10

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Medication: Omeprazole (e.g. Zanprol)	5.7	7.0	10.8	1.8	2.1	-3.0	-2.7	3.3
Chronic bronchitis/emphysema (mother)	5.5	6.5	9.5	1.8	1.1	-3.0	-3.1	3.0
Seen doctor (GP) for nerves, anxiety, tension or depression	5.2	8.0	19.7	2.8	4.4	-0.7	-1.0	3.3
Supplements: Zinc	5.1	5.5	13.9	2.2	3.7	-0.9	-1.2	2.6
High cholesterol (Self-reported)	5.0	8.9	15.9	-4.0	-2.5	2.1	2.4	-3.5
Prostate Cancer	4.9	7.0	14.8	-1.8	-3.8	1.8	2.0	-3.1
Number of children fathered	4.9	5.5	9.7	1.4	1.6	-3.1	-2.7	2.4
Diastolic blood pressure, automated reading	4.9	15.1	21.3	-2.3	-3.1	4.3	4.6	-4.5
Medication: Ramipril	3.7	4.7	7.0	-1.5	-1.5	2.6	2.6	-2.4
Maternal smoking around birth	3.4	4.9	10.0	0.2	0.5	-3.2	-3.2	2.1
Mouth/teeth dental problems: Loose teeth	3.4	4.0	6.1	1.3	0.8	-2.4	-2.4	2.5
Medication: Omeprazole	3.4	4.1	6.3	1.5	1.7	-2.2	-1.9	2.5
Comparative height size at age 10	3.4	18.6	28.6	3.0	4.6	-4.2	-4.0	5.3
Hypertension (Self-reported)	3.3	9.2	14.6	-1.8	-2.3	3.8	3.6	-3.2
Fractured/broken bones in last 5 years	3.3	4.2	6.2	1.8	2.5	-2.0	-1.7	2.2
Cardiovascular Disease	3.1	10.2	14.5	-2.0	-2.4	3.8	3.8	-3.6
Medication: Bendroflumethiazide	3.1	4.7	7.3	-2.0	-2.3	1.7	2.0	-2.7
Medication: Atorvastatin	3.1	3.8	4.8	-1.6	-2.2	1.7	2.1	-2.2
Medication: Ventolin 100micrograms inhaler	3.0	3.9	9.0	0.3	-0.4	-2.5	-3.0	2.0
Average weekly champagne plus white wine intake	3.0	4.1	9.2	-0.8	-0.1	3.0	2.8	-1.7
Age started oral contraceptive pill	3.0	3.7	5.9	-1.8	-1.9	1.7	1.7	-2.4
Mean time to correctly identify matches	2.9	5.6	14.1	-2.6	-3.8	0.5	0.6	-2.5
Number of operations (self-reported)	2.9	4.3	6.1	1.6	1.9	-2.2	-2.1	2.5
Medication: Blood pressure	2.8	5.4	7.5	-1.4	-2.6	2.4	2.2	-2.7
Pain type(s) experienced in last month: Hip pain	2.8	3.5	8.8	2.3	3.0	0.4	0.1	1.7
High blood pressure	2.7	7.6	13.2	-1.4	-1.9	3.6	3.3	-2.9
Chronotype (morning person)	2.6	5.9	13.0	-0.5	0.4	3.3	3.6	-2.2
Reaction Time	2.5	4.7	11.7	-2.4	-3.4	0.7	0.6	-2.3
Medication: Ibuprofen	2.5	2.9	8.8	1.4	3.0	1.2	0.7	1.5
Ulcerative Colitis (UC)	2.4	4.5	9.2	0.5	0.1	-3.0	-3.0	2.1
Supplements: Glucosamine	2.3	3.0	8.5	1.6	2.9	-0.8	-0.5	1.7
Medication: Paracetamol	2.3	3.8	6.4	1.3	0.9	-2.5	-2.5	2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	2.3	2.9	5.2	0.6	2.0	2.3	2.2	-0.0
Vascular/heart problems diagnosed by doctor	2.2	6.1	7.8	1.6	2.4	-2.8	-2.7	2.7
Crohns Disease (2012)	2.1	3.3	7.4	0.8	0.3	-2.4	-2.7	1.7
Schizophrenia (2014)	2.1	4.5	7.9	-1.3	-0.5	2.6	2.8	-2.4
Illnesses of father: None of the above (group 1)	2.1	2.6	5.6	2.4	1.4	-1.1	-1.1	1.7
Hayfever/allergic rhinitis (self-reported)	1.9	2.6	6.5	-1.3	-2.5	-1.6	-1.0	-1.1
Mineral and other dietary supplements	1.9	2.6	8.2	-1.7	-2.9	-0.0	-0.2	-1.3
Wears glasses or contact lenses	1.9	2.2	5.4	-2.3	-2.1	-0.2	-0.3	-1.1
Irritable Bowel Disease (IBD)	1.8	4.4	8.7	1.1	0.1	-2.9	-3.0	1.8
Health satisfaction	1.8	2.3	5.7	-2.4	-1.6	0.6	0.8	-1.5
Medication: Seretide 50 evohaler	1.8	2.1	3.3	1.8	0.5	-1.5	-1.6	1.3
Breastfed as a baby	1.7	2.1	4.7	0.9	0.7	2.2	2.0	-0.6
Qualifications: O levels/GCSEs or equivalent	1.7	2.7	4.6	1.5	0.3	-2.0	-2.2	1.7
Mouth/teeth dental problems: Bleeding gums	1.7	2.2	5.0	-0.2	0.0	2.0	2.2	-1.3
Medication: Lisinopril	1.7	2.2	4.3	-1.4	-2.1	0.6	0.6	-1.9
Commuting to job workplace: Cycle	1.7	2.1	2.9	1.6	1.7	-1.0	-1.1	1.7
Ever unenthusiastic/disinterested for a whole week	1.6	2.0	2.9	-1.3	-1.0	1.7	1.6	-1.3
Father’s age at death	1.6	2.1	3.8	-0.7	-0.5	1.9	2.0	-1.6
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.1	5.8	1.3	2.4	0.7	0.2	1.5
Birth weight of first child	1.6	3.0	4.5	-2.1	-1.1	1.5	1.8	-1.8
Loud music exposure frequency	1.6	1.7	3.9	0.1	-0.8	-2.0	-1.8	0.8
Loneliness, isolation	1.6	2.3	4.8	-0.8	0.3	2.1	2.2	-1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.6	1.9	3.8	-1.8	-1.9	0.1	0.1	-1.6
Osteoporosis (self-reported)	1.6	1.9	3.1	0.8	0.9	-1.4	-1.7	1.8
Chronic bronchitis/emphysema (father)	1.5	1.8	3.4	-1.0	-1.9	-1.4	-1.6	0.0
Medication for pain relief, constipation, heartburn	1.5	2.6	3.5	-1.4	-1.3	1.8	1.7	-1.9
Mouth/teeth dental problems: Mouth ulcers	1.5	2.4	4.8	-0.3	-0.1	2.1	2.2	-1.7
Cholesterol lowering medication	1.5	2.2	4.1	-1.8	-2.0	0.6	0.8	-1.7
Coronary Artery Disease (CAD)	1.4	1.6	3.5	-1.9	-1.5	0.3	0.3	-1.5
Hearing difficulty/problems with background noise	1.4	2.2	4.6	-1.1	-1.2	-1.8	-2.1	0.6
Pain all over the body in last month	1.4	1.5	4.4	1.2	2.1	-0.4	-0.1	1.3
Depression (self-reported)	1.4	1.7	5.0	1.2	2.2	0.5	0.4	1.2
Prospective memory result	1.4	1.7	2.8	-1.4	-1.7	0.5	0.9	-1.7
Tense / ‘highly strung’	1.4	2.3	4.9	-2.2	-1.6	0.8	0.7	-1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.6	2.7	1.6	1.3	-0.8	-0.6	1.6
Medication for cholesterol	1.4	2.1	3.3	1.2	1.8	-1.2	-1.2	1.7
Guilty feelings	1.4	2.2	3.0	-1.6	-1.5	-1.7	-1.7	0.1
Supplements: Fish oil (including cod liver oil)	1.4	1.8	5.4	1.3	2.3	0.9	0.8	0.7
Medication: Paracetamol	1.4	2.1	3.5	1.1	0.8	-1.9	-1.8	1.5
Worry (Nagel 2018)	1.3	2.7	7.9	-1.8	-2.8	-0.5	-0.5	-1.3
Ulcerative Colitis	1.3	1.9	4.0	-0.4	-0.7	-2.0	-1.9	1.1
Lung FEV1/FVC ratio	1.3	6.6	12.6	-0.5	-0.9	3.4	3.6	-2.8
Age when periods started (menarche)	1.3	3.0	6.8	-1.8	-2.6	0.7	0.8	-2.0
Medication: Cholesterol lowering	1.3	2.0	5.5	-2.4	-0.7	0.8	1.2	-1.4
Medication: Amlodipine	1.3	1.8	3.8	-1.2	-1.9	0.8	0.9	-1.6
Medication: Blood pressure	1.3	2.3	5.1	-0.3	-0.4	2.3	2.0	-1.4
Basal cell carcinoma (self-reported)	1.3	1.6	3.2	-0.7	-0.3	1.8	1.6	-1.2
Fasting Glucose	1.2	1.4	2.4	-1.1	0.5	-1.5	-1.6	0.9
Height	1.2	23.0	32.5	0.6	4.9	-5.5	-5.3	5.7
Relative age of first facial hair	1.2	2.4	3.2	-1.4	-1.3	1.6	1.7	-1.8
Systolic blood pressure, automated reading	1.2	3.5	6.1	-0.6	-1.3	2.3	2.5	-2.0
Multivitamins +/- minerals	1.2	1.5	2.4	1.1	1.6	1.4	1.3	0.2
Forced vital capacity (FVC)	1.2	4.6	15.1	1.5	3.9	-0.0	-0.1	2.4
Qualifications: None of the above	1.2	2.6	5.3	-2.3	-1.9	0.4	0.8	-1.8
Pulse rate	1.2	2.0	4.8	0.4	-0.1	-1.7	-2.2	1.4
Standing height	1.2	12.0	17.0	1.0	4.1	-3.7	-3.4	4.1
Glaucoma (self-reported)	1.2	1.4	2.9	0.9	1.3	1.7	1.3	0.0
Gout (self-reported)	1.2	1.7	2.3	1.5	1.5	1.5	1.3	0.1
Birth weight	1.2	2.6	4.2	0.6	2.1	-1.7	-1.4	1.9
Medication: Allopurinol	1.2	1.5	2.4	1.5	1.5	1.3	1.1	0.2
Chest pain or discomfort	1.2	1.8	3.0	-1.0	-0.8	1.6	1.7	-1.2
Eye problems/disorders: Glaucoma	1.2	1.4	3.0	0.5	1.0	1.7	1.5	-0.4
Schizophrenia vs Biploar Disorder	1.1	1.4	3.4	-1.0	-1.9	0.0	0.6	-1.5
Rheumatoid Arthritis	1.1	1.5	2.4	0.6	0.6	-1.5	-1.6	1.5
Heel T-Score	1.1	9.0	18.1	-1.4	-0.3	4.1	4.2	-2.9
Waist Hip Ratio (WHR)	1.1	5.1	15.3	-2.5	-3.9	-0.6	-0.6	-1.8
Systolic Blood Pressure	1.1	5.5	11.6	0.6	-0.5	3.4	3.4	-2.0
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	1.8	-1.1	-1.4	1.0	0.7	-1.3
Qualifications: CSEs or equivalent	1.1	1.4	3.9	2.0	1.3	-0.3	-0.2	1.2
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	2.8	1.0	1.3	-0.5	-0.8	1.7
Alcohol usually taken with meals	1.1	1.7	2.5	-1.2	-0.9	1.6	1.1	-1.6
Nervous feelings	1.1	2.0	6.0	-1.6	-2.4	-0.5	-0.8	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.2	3.5	-0.1	0.1	1.9	1.5	-0.7
Qualifications: College or University degree	1.1	3.6	8.1	-0.8	-0.1	2.9	2.5	-1.7
Alzheimer’s Disease (in father)	1.0	1.1	2.3	-1.5	-0.4	1.0	1.1	-0.8
Mean Putamen Volume	1.0	1.2	2.0	0.6	0.9	-1.1	-1.2	1.4
Leg fat-free mass (left)	1.0	5.1	8.0	0.8	2.8	-2.2	-2.0	2.8
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.2	4.8	-0.1	0.2	2.2	2.0	-1.4
Medication: Atenolol	1.0	1.2	2.5	-0.8	-1.6	0.7	0.6	-1.4
Sitting height	1.0	7.3	18.4	1.2	4.3	-2.0	-1.7	3.1
Leg predicted mass (left)	1.0	5.1	8.2	0.8	2.9	-2.2	-2.0	2.8
Impedance of arm (right)	1.0	4.8	7.1	2.1	1.7	-2.0	-2.3	2.7
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	2.1	-1.5	-0.8	1.4	1.4	-1.3
Length of working week for main job	1.0	1.1	2.2	0.1	0.4	1.5	1.5	-0.9
Peak expiratory flow (PEF)	1.0	2.2	4.1	1.4	2.0	1.7	1.5	0.3
Ever taken oral contraceptive pill	1.0	1.1	2.5	-1.6	-1.5	-0.4	-0.1	-0.8
Supplements: Calcium	1.0	1.1	1.9	0.3	1.0	-1.0	-1.4	1.2
Intelligence (Savage-Jansen 2018)	0.9	2.8	4.6	1.5	1.8	-1.2	-1.4	2.1
Lung FVC	0.9	4.5	10.6	-0.2	1.0	3.2	3.0	-1.3
Average weekly spirits intake	0.9	1.1	2.9	-0.4	-0.9	-1.7	-1.2	-0.1
Ever used hormone-replacement therapy (HRT)	0.9	1.2	2.8	-0.6	-0.0	1.4	1.7	-0.9
Severe depression (siblings)	0.9	1.0	2.7	1.6	1.2	0.0	-0.1	1.0
Medication: Simvastatin	0.9	1.3	4.1	-2.0	-1.0	-0.0	0.3	-1.2
Alcohol intake versus 10 years previously	0.9	1.4	2.1	-1.3	-1.0	0.9	1.3	-1.5
Forced expiratory volume in 1-second (FEV1)	0.9	3.1	10.0	1.4	3.2	1.2	1.1	1.1
Happiness	0.9	1.1	3.0	-1.4	-1.7	-0.2	-0.6	-0.5
Worry too long after embarrassment	0.9	1.6	3.6	-1.1	-1.9	0.7	0.5	-1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.0	2.2	-0.7	-0.1	-1.4	-1.5	0.7
Had major operations	0.9	1.0	2.4	0.9	1.6	-0.2	-0.5	1.3
Leg fat-free mass (right)	0.9	4.8	8.5	0.8	2.9	-2.0	-1.8	2.7
Asthma (self-reported)	0.9	1.8	3.8	0.4	-0.6	-1.9	-2.0	1.2
Leg predicted mass (right)	0.9	4.9	8.4	0.8	2.9	-2.1	-1.9	2.7
Mother’s age at death	0.9	1.2	2.4	0.6	1.0	1.5	1.4	-0.3
Financial situation satisfaction	0.9	1.1	3.4	-1.8	-1.1	0.3	0.5	-0.8
Pain experienced in last month	0.9	1.5	3.5	-1.2	-1.9	0.5	0.5	-1.5
Deep venous thrombosis (DVT) (self-reported)	0.9	1.1	2.1	1.4	0.8	1.4	1.0	0.3
Neuroticism (Nagel 2018)	0.8	1.9	4.6	-1.7	-2.2	-0.1	-0.1	-1.3
Bipolar Disorder (2011)	0.8	0.7	2.4	0.0	0.0	1.6	1.1	0.2
Respiratory disease	0.8	1.8	3.4	0.7	-0.2	-1.8	-1.8	1.3
Vitamin and mineral supplements	0.8	1.1	2.1	-1.0	-1.5	-1.0	-1.0	-0.2
Hayfever, allergic rhinitis or eczema	0.8	1.7	5.4	-1.2	-2.3	-0.5	-0.5	-1.1
Asthma	0.8	1.6	3.4	0.5	-0.4	-1.7	-1.8	1.2
Blood clot in the leg (DVT)	0.8	1.0	1.9	1.4	0.7	1.4	0.9	0.3
Forced vital capacity (FVC), Best measure	0.8	2.8	10.5	1.0	3.2	0.3	0.5	1.4
Eye problems/disorders: None of the above	0.8	1.0	2.4	0.2	-0.9	-1.5	-1.3	-0.0
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	1.9	0.5	0.4	-1.4	-1.3	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.6	3.0	0.5	1.4	-1.7	-1.2	1.2
Average weekly red wine intake	0.8	1.2	1.7	-0.8	-1.2	1.3	1.0	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	2.4	-0.4	-1.6	-1.1	-0.8	-0.4
Miserableness	0.8	1.4	3.3	1.2	1.8	0.9	0.9	0.9
Basal metabolic rate	0.8	4.2	5.9	0.4	2.4	-2.3	-2.0	2.4
Breast Cancer	0.7	1.7	3.8	-0.8	0.1	1.9	1.8	-0.8
Ever had hysterectomy (womb removed)	0.7	0.8	1.5	1.2	1.0	0.8	0.7	0.6
Average weekly fortified wine intake	0.7	0.9	1.3	1.2	0.6	-0.5	-1.0	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	3.1	-1.8	-0.5	0.6	0.7	-0.7
Taking other prescription medications	0.7	1.1	1.5	1.1	0.8	-1.0	-1.0	1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.5	3.1	-0.0	0.3	1.8	1.8	-1.1
Mouth/teeth dental problems	0.7	1.1	1.6	0.8	1.2	-0.9	-1.0	1.3
Trunk fat-free mass	0.7	4.0	6.4	0.2	2.5	-2.2	-1.9	2.2
Hair/balding pattern: Pattern 3	0.7	1.0	2.3	1.5	1.0	0.7	0.7	0.8
Pulse wave Arterial Stiffness index	0.7	0.9	1.5	0.2	1.1	-0.8	-0.9	1.2
Trunk predicted mass	0.7	4.2	6.5	0.2	2.5	-2.3	-2.0	2.3
Exposure to tobacco smoke at home	0.7	0.8	1.7	-1.3	-1.1	0.2	0.5	-1.0
Angina (self-reported)	0.7	1.0	2.9	-1.1	-1.7	-0.4	0.0	-0.7
Overall health rating	0.7	1.4	3.0	-1.7	-1.7	0.4	0.3	-0.9
Whole body fat-free mass	0.7	4.3	6.8	0.4	2.6	-2.2	-1.9	2.4
Back pain experienced in last month	0.7	1.0	2.6	0.8	1.6	0.4	0.2	1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	2.9	0.3	1.2	1.7	1.7	-0.3
Whole body water mass	0.7	4.1	6.6	0.4	2.6	-2.2	-1.9	2.3
Irritability	0.7	1.2	2.2	-1.5	-1.2	0.5	0.4	-1.4
Bipolar Disorder or Schizophrenia	0.6	1.4	2.4	-0.1	-0.5	1.5	1.5	-1.5
Schizophrenia (2018)	0.6	1.3	2.4	-0.8	-0.9	1.1	1.3	-1.5
Alzheimer’s Disease (in mother)	0.6	0.7	2.4	1.6	0.8	0.2	-0.1	0.5
Crohns Disease (2017)	0.6	1.4	2.7	1.2	0.1	-1.5	-1.6	0.7
Allergy or Eczema	0.6	1.6	5.3	-1.4	-2.3	-0.3	-0.4	-0.9
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	1.6	-0.1	0.1	1.3	1.2	-0.4
Relative age voice broke	0.6	1.0	2.8	0.5	0.2	1.7	1.2	-0.5
Number of incorrect matches in round	0.6	1.0	2.3	0.0	1.5	1.3	0.9	0.4
Falls in the last year	0.6	0.8	2.7	-1.6	-0.8	0.1	0.2	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.1	6.1	0.8	2.5	1.3	1.4	0.3
Pulse wave reflection index	0.6	0.7	1.5	-0.5	0.8	1.1	1.2	-0.2
High blood pressure (siblings)	0.6	0.8	1.6	0.5	1.3	1.0	1.1	0.1
Number of full brothers	0.6	0.8	1.7	-0.6	-1.0	-1.3	-1.0	0.1
Pulse wave peak to peak time	0.6	0.7	1.2	-0.2	-0.9	0.8	0.9	-1.1
Pulse rate, automated reading	0.6	1.9	4.2	-0.3	-1.3	-1.8	-2.0	0.5
Supplements: Vitamin C	0.6	0.7	2.2	1.0	1.5	0.3	0.3	0.5
Illnesses of father: Heart disease	0.6	0.8	1.5	-0.3	1.0	1.2	1.2	-0.5
Friendships satisfaction	0.6	0.8	1.9	-1.4	-0.9	-0.6	-0.8	-0.2
Illnesses of father: High blood pressure	0.6	0.8	1.2	-0.6	-0.8	1.1	1.0	-0.9
Smoking Status	0.5	1.3	2.7	0.5	0.6	-1.6	-1.3	1.2
Angina	0.5	0.7	2.0	-0.7	-1.4	-0.8	-0.4	-0.3
Medication for hormone replacement therapy	0.5	0.5	0.9	0.2	1.0	0.9	0.9	-0.1
Medication: Co-codamol	0.5	0.5	0.9	0.5	0.4	-1.0	-1.0	0.7
Hand grip strength (right)	0.5	1.4	4.9	1.0	2.2	0.3	0.5	0.7
Serious illness, injury or assault to yourself	0.5	0.6	1.8	0.3	1.4	0.7	0.4	0.8
Allergy	0.5	1.2	3.3	0.5	1.8	1.0	1.2	0.2
Diabetes (self-reported)	0.5	0.7	1.8	-1.2	-1.3	-0.4	-0.3	-0.3
Weight	0.5	2.3	3.6	0.3	1.5	-1.9	-1.4	1.8
Worrier / anxious feelings	0.5	0.9	1.9	-0.9	-1.4	0.7	0.7	-0.9
Noisy workplace	0.5	0.6	1.4	-0.4	-0.4	-1.2	-1.1	0.6
Illnesses of mother	0.5	0.6	1.4	-0.1	0.1	-1.0	-1.2	0.8
Impedance of arm (left)	0.5	2.5	4.0	1.8	1.3	-1.1	-1.4	2.0
Arm fat mass (right)	0.5	1.9	3.4	0.8	0.7	-1.8	-1.5	1.7
Whole body fat mass	0.5	1.9	4.0	0.3	0.6	-2.0	-1.6	1.6
Illnesses of siblings: Diabetes	0.5	0.7	1.2	1.1	1.0	0.2	-0.0	1.0
Ever had bowel cancer screening	0.5	0.6	2.0	-0.7	1.4	-0.2	0.3	0.5
Diabetes diagnosed by doctor	0.5	0.9	2.2	-1.5	-1.3	-0.5	-0.3	-0.3
Commuting to job workplace: Walk	0.5	0.5	1.2	0.2	0.1	-0.8	-1.1	0.8
Arm fat mass (left)	0.5	2.0	3.4	0.8	0.8	-1.8	-1.5	1.8
Average weekly beer plus cider intake	0.5	0.8	2.0	-0.8	-1.4	0.3	0.5	-1.0
Alcohol drinker status: Previous	0.5	0.5	2.5	-0.2	-1.6	0.1	-0.2	-0.3
Bipolar Disorder (2018)	0.4	0.6	1.1	1.0	0.4	1.0	0.8	-0.4
Primary Biliary Cirrhosis	0.4	0.6	1.0	1.0	0.4	-1.0	-0.7	0.8
Type 2 Diabetes (T2D) (2018)	0.4	0.8	1.8	-1.4	-1.4	-0.4	-0.3	-0.5
Neuroticism	0.4	1.0	2.5	-1.3	-1.6	0.1	0.1	-0.9
Hand grip strength (left)	0.4	1.1	3.3	0.9	1.8	0.7	1.0	0.3
Hearing difficulty/problems: Yes	0.4	0.7	1.5	-0.3	-0.5	-1.2	-1.2	0.3
Medication: Metformin	0.4	0.5	1.3	-1.1	-1.0	0.3	0.1	-0.5
Diabetes (mother)	0.4	0.6	1.0	-1.0	-1.0	-0.8	-0.4	-0.3
Trunk fat mass	0.4	1.7	3.8	0.2	0.5	-1.9	-1.5	1.5
Had other major operations	0.4	0.5	0.8	-0.3	0.7	-0.9	-0.8	0.6
Financial difficulties in last 2 years	0.4	0.6	1.0	-0.7	0.5	1.0	1.0	-0.5
Arm fat percentage (right)	0.4	1.6	2.7	1.0	0.4	-1.6	-1.3	1.6
Hip circumference	0.4	1.8	2.9	0.4	1.1	-1.7	-1.4	1.6
Number of live births	0.4	0.6	1.5	0.6	1.2	-0.1	-0.3	1.1
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	0.8	-0.9	-0.3	0.5	0.6	-0.9
Medication: Lansoprazole	0.4	0.4	1.1	-0.4	-0.3	-1.0	-0.8	0.4
Headache pain in last month	0.4	0.7	1.7	0.7	-0.1	-1.3	-0.9	0.7
Alcohol intake frequency.	0.4	0.9	1.4	0.8	-0.0	-1.2	-1.0	1.1
Age at last live birth	0.4	0.5	1.2	0.8	0.5	-0.4	-0.7	1.1
Smoking status: Previous	0.4	0.6	1.2	0.3	0.1	-1.1	-1.1	0.8
Osteoarthritis (self-reported)	0.4	0.5	1.0	0.8	1.0	0.3	0.0	0.8
Medication: Gliclazide	0.4	0.4	0.8	-0.6	-0.9	0.1	0.4	-0.9
Commuting to job workplace: Public transport	0.4	0.5	1.5	-1.2	-0.7	-0.5	-0.6	-0.4
Arm fat-free mass (left)	0.4	2.0	3.8	-0.3	1.4	-1.9	-1.5	1.4
Risk taking	0.4	0.6	1.4	0.2	0.9	1.2	1.0	-0.2
Ever had prostate specific antigen (PSA) test	0.4	0.5	0.9	-1.0	-0.3	0.7	0.9	-0.4
Unable to work because of sickness or disability	0.4	0.5	1.8	-1.4	-0.6	0.2	0.4	-0.4
Arm predicted mass (left)	0.4	2.2	3.9	-0.1	1.5	-2.0	-1.5	1.5
Depression (Nagel 2018)	0.3	0.4	1.1	-1.0	-0.7	-0.5	-0.5	-0.1
LDL Cholesterol	0.3	0.5	0.7	-0.7	-0.3	0.8	0.8	-0.6
Triglycerides	0.3	0.4	0.8	0.9	0.8	-0.3	-0.5	0.6
Blood Red Count	0.3	3.1	7.2	-0.5	0.6	2.7	2.6	-0.8
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	0.9	-0.1	0.2	-0.9	-0.9	0.5
Medication: Levothyroxine sodium	0.3	0.4	0.9	-1.0	-0.5	0.3	0.5	-0.8
High blood pressure (mother)	0.3	0.5	0.7	0.6	0.9	0.8	0.8	0.1
Waist circumference	0.3	1.0	2.3	-0.4	-1.0	-1.5	-1.2	0.3
Fluid intelligence score	0.3	0.7	1.0	0.8	0.7	-0.5	-1.0	0.9
Neuroticism score	0.3	0.6	1.6	-0.7	-1.3	0.4	0.3	-0.6
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.1	0.6	-0.1	-1.0	-0.9	0.6
Arm fat-free mass (right)	0.3	1.3	2.2	-0.8	1.3	-1.5	-1.1	1.1
Exposure to tobacco smoke outside home	0.3	0.4	0.7	-0.1	0.6	-0.8	-0.8	0.8
Comparative body size at age 10	0.3	0.8	1.8	1.1	1.4	-0.3	0.2	0.9
Wheeze or whistling in the chest in last year	0.3	0.5	1.0	0.1	0.4	-0.9	-0.9	1.0
Migraine (self-reported)	0.3	0.3	0.9	0.0	-0.7	-0.6	-0.9	0.2
Arm predicted mass (right)	0.3	1.3	2.3	-0.8	1.1	-1.5	-1.2	1.0
Suffer from ‘nerves’	0.3	0.5	0.8	-0.6	-0.9	-0.7	-0.9	0.1
Leg pain on walking	0.3	0.3	0.7	-0.8	-0.8	-0.1	0.2	-0.5
Medication: Aspirin	0.3	0.3	0.8	-0.1	-0.7	-0.9	-0.6	-0.1
Arm fat percentage (left)	0.3	1.0	1.7	0.8	0.3	-1.2	-1.0	1.3
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.9	-0.1	0.1	1.0	0.7	-0.4
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.7	-0.6	-0.6	-0.5	-0.8	-0.0
Heart disease (siblings)	0.3	0.4	0.8	0.0	-0.3	0.9	0.8	-0.5
Depressed Affect (Nagel 2018)	0.2	0.5	0.8	-0.5	-0.2	0.8	0.9	-0.9
Major Depression (MDD)	0.2	0.3	1.3	0.0	0.0	-0.2	0.1	-1.1
Ovarian Cancer	0.2	0.3	0.5	0.6	0.0	-0.3	-0.7	0.7
Age at First Birth	0.2	0.3	0.7	-0.4	-0.8	-0.6	-0.5	-0.2
Body Mass Index (BMI) (2010)	0.2	0.2	0.9	-0.1	0.9	-0.2	-0.1	0.4
HDL Cholesterol	0.2	0.3	0.6	0.4	0.1	-0.7	-0.6	0.8
Neuroticism (2016)	0.2	0.3	0.6	0.5	0.6	-0.2	-0.6	0.8
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.4	0.1	0.4	-0.6	-0.4	0.5
Blood Platelet Count	0.2	2.5	4.7	-0.2	-2.1	-2.2	-1.9	0.2
Tanning	0.2	2.9	5.7	2.0	2.4	-0.8	-0.9	1.9
Number of treatments/medications taken	0.2	0.3	0.7	0.4	0.8	0.4	0.5	0.1
Diabetes (father)	0.2	0.2	0.4	-0.3	0.3	0.5	0.7	-0.5
Impedance of leg (right)	0.2	1.0	2.9	-0.9	-1.7	-0.3	-0.2	-1.0
Trunk fat percentage	0.2	0.9	2.2	0.2	-0.1	-1.5	-1.1	1.0
Current tobacco smoking	0.2	0.3	0.9	0.2	0.9	-0.5	-0.2	0.7
Impedance of leg (left)	0.2	1.0	3.2	-0.9	-1.8	-0.5	-0.3	-1.0
Past tobacco smoking	0.2	0.3	0.9	0.2	0.2	0.9	0.6	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.4	-1.2	0.3	0.2	0.3	0.1
Had menopause	0.2	0.2	0.6	-0.8	-0.6	0.0	-0.1	-0.2
Heart attack	0.2	0.3	0.7	-0.8	-0.8	0.2	0.3	-0.3
Time employed in main current job	0.2	0.2	0.5	0.1	-0.7	0.4	0.4	-0.5
Mouth/teeth dental problems: Dentures	0.2	0.4	0.6	-0.4	-0.8	-0.7	-0.7	0.2
Body fat percentage	0.2	0.7	1.8	-0.0	-0.4	-1.3	-1.0	0.8
Emphysema/chronic bronchitis	0.2	0.2	0.3	0.4	0.1	-0.5	-0.6	0.4
Neck or shoulder pain in last month	0.2	0.3	0.6	0.1	0.7	-0.3	-0.7	0.8
Leg fat mass (right)	0.2	0.8	2.0	-0.3	0.1	-1.4	-1.0	1.0
Number of full sisters	0.2	0.3	0.6	-0.8	-0.4	0.3	0.3	-0.5
Knee pain experienced in last month	0.2	0.4	1.0	-1.0	-0.6	-0.4	-0.1	-0.5
Qualifications: nursing, teaching	0.2	0.3	0.6	0.8	-0.4	-0.5	-0.5	0.3
Breast cancer (self-reported)	0.2	0.2	0.6	-0.1	-0.3	-0.7	-0.6	0.0
Medication: Aspirin	0.2	0.3	0.7	0.1	-0.4	-0.8	-0.6	0.2
Hearing aid user	0.2	0.2	0.7	-0.8	-0.5	-0.0	0.3	-0.3
Ever depressed for a whole week	0.2	0.2	0.4	0.5	0.5	0.7	0.4	0.2
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.7	-0.8	-0.8	0.1	0.2	-0.3
Pack years of smoking	0.2	0.2	1.1	0.2	-1.1	0.2	0.1	-0.0
Leg fat mass (left)	0.2	0.7	1.7	-0.3	-0.0	-1.3	-0.9	0.8
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.8	-0.1	-0.9	-0.6	-0.7	0.1
HbA1C	0.1	0.1	0.5	0.1	0.2	0.7	0.3	-0.2
Lupus	0.1	0.1	0.5	-0.5	-0.0	-0.7	-0.1	-0.1
Blood Eosinophil Count	0.1	0.6	1.1	-0.6	0.1	-1.0	-0.8	0.8
Hypothyroidism (self reported)	0.1	0.3	0.6	-0.5	0.8	0.4	0.5	-0.1
Sensitivity / hurt feelings	0.1	0.1	0.2	0.5	-0.3	0.0	0.0	0.4
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.2	-0.5	0.1	-0.2	-0.3	0.5
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.5	-0.7	-0.3	0.1	-0.1	-0.3
Pack years adult smoking proportion	0.1	0.2	0.7	0.2	-0.8	0.0	-0.1	0.2
Townsend deprivation index at recruitment	0.1	0.1	0.4	-0.2	0.0	-0.6	-0.4	0.3
Fed-up feelings	0.1	0.1	0.4	-0.6	-0.4	0.2	0.3	-0.3
Stomach or abdominal pain in last month	0.1	0.2	0.5	-0.7	-0.5	0.1	0.0	-0.3
Hair/balding pattern: Pattern 2	0.1	0.1	0.3	-0.3	0.1	-0.5	-0.5	-0.2
Illnesses of siblings	0.1	0.1	0.2	-0.4	-0.1	-0.4	-0.4	-0.1
Qualifications: A levels/AS levels or equivalent	0.1	0.1	0.4	0.7	-0.2	0.1	-0.3	0.2
Lung cancer (father)	0.1	0.2	0.4	0.1	-0.2	0.6	0.5	-0.3
Hair/balding pattern: Pattern 4	0.1	0.2	0.8	-0.9	-0.3	0.1	0.0	-0.6
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.2	-0.4	0.3	0.4	0.5	-0.4
Leg fat percentage (right)	0.1	0.3	0.9	-0.6	-1.0	-0.5	-0.1	-0.1
Age at first live birth	0.1	0.2	0.6	0.3	-0.8	-0.3	-0.5	-0.0
Shortness of breath walking on level ground	0.1	0.1	0.2	0.4	-0.4	-0.1	0.2	-0.2
Heart disease (mother)	0.1	0.1	0.3	-0.5	0.1	-0.2	-0.1	-0.1
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.1	-0.2	-0.2	0.2	0.3	-0.3
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.6	0.8	-0.3	0.2	0.1	-0.2
Long-standing illness, disability or infirmity	0.1	0.2	0.7	-0.9	-0.4	0.1	0.0	-0.3
Eye problems/disorders: Cataract	0.1	0.1	0.2	-0.4	-0.3	-0.5	-0.3	0.3
Smoking status: Current	0.1	0.2	0.6	-0.0	0.8	-0.2	0.1	0.4
Number of self-reported non-cancer illnesses	0.1	0.2	0.4	-0.1	-0.7	0.6	0.3	-0.3
Alcohol drinker status: Never	0.1	0.1	0.2	-0.1	-0.4	0.5	0.3	-0.1
Ever smoked	0.1	0.1	0.3	-0.4	0.1	-0.5	-0.3	0.1
Leg fat percentage (left)	0.1	0.4	1.1	-0.6	-1.1	-0.6	-0.1	-0.2
Myopia	0.1	0.1	0.2	-0.2	-0.2	0.3	0.3	-0.4
Impedance of whole body	0.1	0.5	0.9	0.7	-0.1	-0.9	-1.0	0.6
Alzheimer’s Disease (including proxy)	0.0	0.0	0.0	-0.2	0.1	0.2	-0.0	-0.0
Blood White Count	0.0	0.2	0.5	0.1	0.2	0.7	0.7	0.1
BMI	0.0	0.2	0.6	-0.2	-0.8	-0.3	-0.1	-0.1
Hair Pigment	0.0	1.0	2.7	-1.0	-1.6	-0.7	-0.2	-1.0
Body mass index (BMI)	0.0	0.1	0.2	-0.1	-0.4	-0.3	0.0	-0.1
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.1	-0.2	0.1	0.1	-0.1	0.4
Family relationship satisfaction	0.0	0.0	0.1	0.1	0.2	0.3	0.1	0.2
Mood swings	0.0	0.1	0.3	-0.6	-0.2	0.1	0.0	0.1

Hub : Genes

MOB2

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Trait associations