Hub : Genes

NRIP2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.112 0.0310 1.1e-04 -0.002 0.040 0.002 0.035 0.002 0.7300 1.0e-05 1.5e-01 3.5e-05 1.7e-01
2 GTEx Brain Putamen basal ganglia 0.479 0.1320 1.2e-03 0.069 NA 0.213 NA 0.201 0.0100 NA 8.8e-06 NA 1.6e-05
3 GTEx Skin Sun Exposed Lower leg 0.172 0.0600 5.3e-03 0.003 NA -0.002 NA -0.003 0.1900 NA 6.1e-01 NA 8.7e-01
4 ROSMAP Brain Pre-frontal Cortex 0.140 0.0332 4.5e-08 0.018 0.054 0.058 0.064 0.056 0.0021 1.6e-07 5.0e-08 1.1e-08 8.6e-08

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.5 0.8 2.1 -0.3 0.9 -0.6 1.4
Bipolar Disorder or Schizophrenia 0.7 1.7 2.3 -1.0 1.0 -1.5 1.5
Depressed Affect (Nagel 2018) 0.3 0.6 2.3 0.1 1.5 0.4 -0.3
Depression (Nagel 2018) 0.7 1.0 2.6 0.3 1.6 0.7 0.9
Intelligence (Savage-Jansen 2018) 0.4 1.1 1.8 -0.5 -1.3 -1.3 -0.9
Neuroticism (Nagel 2018) 0.2 0.6 1.6 -0.6 0.1 0.5 -1.3
Schizophrenia (2018) 0.5 1.1 1.9 -1.1 0.6 -1.4 0.8
Schizophrenia vs Biploar Disorder 0.6 0.7 1.4 -0.8 -0.9 -1.2 -0.4
Worry (Nagel 2018) 0.6 1.3 2.5 -1.5 -0.6 -0.0 -1.6
Alzheimer’s Disease (in mother) 0.2 0.2 0.3 -0.3 -0.3 -0.5 -0.6
Alzheimer’s Disease (in father) 0.5 0.6 2.1 -0.4 -0.0 -1.5 -0.2
Alzheimer’s Disease (including proxy) 1.1 1.6 3.5 -1.0 -0.8 -1.9 -1.1
Crohns Disease (2017) 1.1 2.4 4.9 -0.7 -2.2 1.7 -1.2
Irritable Bowel Disease (IBD) 0.3 0.8 1.3 1.0 -0.9 1.1 0.2
Ulcerative Colitis (UC) 0.5 1.0 2.7 1.6 0.2 0.7 0.8
Major Depression (MDD) 0.1 0.2 0.3 -0.3 0.2 -0.6 -0.4
Reaction Time 0.8 1.4 2.5 -1.2 -1.6 -0.1 -1.4
Verbal and Numeric Reasoning (VNR) 0.4 1.0 2.0 -1.4 -1.0 -0.2 -0.9
Breast Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Ovarian Cancer 0.8 1.0 2.9 0.1 1.1 -0.1 1.7
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.2 0.3 1.0 -0.4 1.0 -0.2 0.3
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.6 0.9 3.1 0.2 0.5 1.8 -0.0
Coronary Artery Disease (CAD) 0.5 0.6 1.1 -0.9 1.1 -0.3 0.7
Crohns Disease (2012) 1.4 2.3 4.0 -0.9 -2.0 1.5 -1.5
Mean Putamen Volume 2.4 2.8 6.4 -2.0 -0.5 0.7 -2.5
Fasting Glucose 2.2 2.7 5.7 -2.4 1.5 0.6 -1.6
HbA1C 1.7 1.9 4.1 -1.6 0.9 2.0 -0.3
HDL Cholesterol 0.4 0.6 2.3 0.1 -0.5 -1.5 0.1
LDL Cholesterol 0.0 0.0 0.0 -0.0 0.1 -0.1 0.1
Lupus 0.7 1.1 2.7 -0.4 -1.6 -1.2 0.3
Neuroticism (2016) 0.6 0.8 1.9 -0.4 -0.0 -1.1 -1.4
Primary Biliary Cirrhosis 0.4 0.6 1.9 0.5 -1.4 -0.1 -0.5
Rheumatoid Arthritis 1.1 1.5 5.1 -0.5 -0.7 2.3 0.0
Schizophrenia (2014) 0.7 1.5 2.8 -0.4 0.9 -1.4 1.7
Triglycerides 0.2 0.3 0.7 -0.4 -0.4 0.3 -0.8
Type 2 Diabetes (T2D) (2012) 1.6 1.8 3.3 0.8 1.0 1.5 1.8
Ulcerative Colitis 0.5 0.8 1.8 1.3 -0.1 0.3 1.1
Blood Eosinophil Count 0.1 0.8 2.6 1.6 -0.4 -0.2 0.7
Blood Platelet Count 0.2 2.1 5.7 -0.4 1.3 0.9 2.4
Blood Red Count 0.4 3.6 7.3 1.7 -0.3 2.7 -2.0
Blood White Count 0.6 4.5 8.9 1.5 2.4 1.0 3.0
Heel T-Score 0.4 3.0 8.9 -1.1 1.2 -3.0 -0.7
BMI 0.2 1.2 2.0 1.2 -1.4 -0.2 -1.2
Height 0.8 15.2 27.7 -2.2 -5.3 3.3 -4.2
Waist Hip Ratio (WHR) 0.4 1.8 4.5 0.6 0.5 2.1 1.5
Systolic Blood Pressure 0.2 0.8 1.6 1.0 1.3 -0.7 -0.5
Smoking Status 1.0 2.3 5.1 1.1 0.7 2.3 1.6
Allergy or Eczema 0.1 0.3 0.6 0.8 0.1 -0.6 -0.1
Cardiovascular Disease 0.3 0.8 2.3 1.5 0.6 -0.7 0.3
Hypothyroidism (self reported) 0.2 0.3 0.5 0.7 0.5 -0.6 -0.6
Respiratory disease 0.3 0.7 1.2 0.6 1.0 0.6 1.1
Type 2 Diabetes (T2D) (2018) 1.4 2.7 8.5 -0.7 -0.9 -2.9 -0.9
Lung FEV1/FVC ratio 0.6 3.2 8.4 -0.5 -1.7 2.9 -1.1
Lung FVC 0.7 3.8 6.6 -2.1 2.0 0.5 2.6
Neuroticism 0.0 0.1 0.3 -0.1 -0.1 0.2 -0.5
Chronotype (morning person) 0.9 2.1 4.7 1.1 0.7 -2.2 1.3
Hair Pigment 0.0 0.7 2.1 -0.5 -1.4 -0.0 -0.6
Tanning 0.1 1.2 4.4 -2.1 -0.6 0.2 -0.3
Hand grip strength (left) 0.4 1.1 2.7 -1.6 -0.5 1.1 0.3
Number of treatments/medications taken 0.1 0.2 0.7 0.0 0.3 0.8 0.0
Average weekly spirits intake 0.8 1.0 2.3 0.8 1.5 0.3 1.1
Sensitivity / hurt feelings 0.7 1.1 3.7 0.9 -0.0 1.9 -0.2
Frequency of depressed mood in last 2 weeks 0.2 0.3 0.9 -0.1 0.9 0.5 -0.2
Hearing difficulty/problems: Yes 1.7 2.5 6.3 -0.7 -0.9 1.6 -2.5
Relative age of first facial hair 0.0 0.0 0.1 -0.3 0.2 0.2 0.1
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 2.9 0.5 -0.2 1.7 -0.1
Ever used hormone-replacement therapy (HRT) 0.5 0.6 1.8 -0.8 -0.1 0.2 -1.3
Ever had hysterectomy (womb removed) 0.9 1.0 2.5 1.0 0.0 1.6 0.8
Systolic blood pressure, automated reading 0.2 0.7 1.2 0.9 1.1 -0.8 0.0
Eye problems/disorders: Diabetes related eye disease 1.1 1.2 4.2 -0.0 -0.6 -2.0 -0.6
Angina 0.4 0.6 1.1 0.4 0.7 -1.0 0.7
Medication for hormone replacement therapy 0.9 1.0 3.8 -1.9 0.3 0.0 -0.4
Vitamin and mineral supplements 1.2 1.6 3.1 1.1 1.8 -1.2 0.8
Supplements: Zinc 0.2 0.2 0.5 -0.4 0.1 -0.3 -0.7
Medication: Co-codamol 2.7 3.1 6.5 2.5 1.2 -1.4 1.6
Medication: Metformin 0.6 0.9 3.2 0.2 -0.1 -1.8 0.5
Diabetes (father) 1.6 2.0 2.7 1.6 1.0 -1.3 1.7
Diabetes (mother) 1.3 1.7 5.9 -0.2 -2.4 -0.6 -0.8
Severe depression (siblings) 0.7 0.8 1.6 -1.3 -1.1 -0.3 -0.5
Pack years adult smoking proportion 1.4 2.2 3.7 -1.1 -1.5 -1.3 -1.9
Impedance of leg (right) 0.2 0.8 2.1 0.6 0.3 1.5 0.8
Leg fat-free mass (left) 1.0 5.3 10.7 -1.7 -3.3 -0.1 -2.8
Trunk fat percentage 0.8 3.4 6.5 0.6 -2.5 -1.3 -2.2
Hand grip strength (right) 1.1 3.1 6.4 -2.5 -1.4 1.7 -1.1
Townsend deprivation index at recruitment 2.1 2.9 4.9 -0.7 -2.0 -2.2 -1.5
Current tobacco smoking 0.4 0.6 1.2 0.3 1.0 1.1 0.6
Average weekly fortified wine intake 1.2 1.4 3.0 -0.6 -1.4 0.5 -1.7
Maternal smoking around birth 0.8 1.1 2.3 -0.4 -1.1 -0.8 -1.5
Fed-up feelings 0.4 0.7 2.6 0.4 1.6 -0.3 -0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 0.6 -0.1 0.7 0.0 0.7
Relative age voice broke 0.4 0.6 1.8 -0.1 1.3 -0.4 0.6
Taking other prescription medications 0.3 0.4 1.2 -0.3 -0.3 -0.6 -1.1
Age when periods started (menarche) 0.3 0.8 2.0 -0.4 -0.9 -0.3 -1.4
Bilateral oophorectomy (both ovaries removed) 1.7 2.0 3.3 1.2 1.8 0.6 1.6
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.7 1.1 -0.7 0.6 -1.1 -0.9
Tinnitus: Yes, but not now, but have in the past 0.5 0.5 1.4 0.4 0.1 1.2 -0.7
Qualifications: CSEs or equivalent 0.4 0.5 1.0 -0.2 -0.7 -0.7 -1.0
Serious illness, injury or assault to yourself 0.1 0.1 0.4 0.6 -0.2 -0.1 0.1
High blood pressure 0.1 0.2 0.4 0.6 0.4 -0.1 -0.1
Hayfever, allergic rhinitis or eczema 0.1 0.1 0.3 -0.1 0.1 -0.6 -0.4
Multivitamins +/- minerals 1.4 1.8 4.7 -1.1 -0.8 2.2 -0.7
Stomach or abdominal pain in last month 1.0 1.2 3.5 -0.4 -1.1 -0.1 -1.9
Supplements: Glucosamine 0.5 0.7 1.9 -0.2 -0.8 0.2 -1.4
Diverticular disease/diverticulitis (self-reported) 0.7 0.8 1.7 -0.2 -1.2 -0.4 -1.3
Medication: Atenolol 0.7 0.9 2.1 -0.7 -0.7 -1.4 -0.9
Medication: Levothyroxine sodium 0.5 0.9 2.9 1.7 0.6 -0.5 0.1
Sitting height 0.8 5.4 12.1 -1.8 -2.4 0.6 -3.5
Chronic bronchitis/emphysema (father) 2.8 3.3 5.6 2.4 1.8 0.3 2.0
High blood pressure (mother) 0.7 1.0 2.5 0.8 -1.6 0.7 -0.5
Body mass index (BMI) 0.3 1.4 2.5 0.4 -1.6 -1.0 -1.3
Impedance of leg (left) 0.1 0.3 0.3 0.6 0.6 0.4 0.5
Leg predicted mass (left) 1.1 5.7 11.2 -1.8 -3.3 -0.0 -2.9
Trunk fat mass 0.9 3.9 8.3 0.1 -2.9 -0.9 -2.5
Waist circumference 0.4 1.5 3.4 0.5 -1.8 -0.2 -1.5
Number of incorrect matches in round 0.1 0.1 0.2 -0.2 -0.4 -0.2 -0.4
Past tobacco smoking 1.3 2.5 4.6 -1.3 -0.7 -1.8 -2.2
Alcohol usually taken with meals 0.6 1.0 1.8 1.3 0.9 0.4 1.0
Nervous feelings 0.6 1.0 1.3 -1.1 -1.1 -0.6 -1.1
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.4 0.9 0.2 0.9 -0.7 0.3
Hearing difficulty/problems with background noise 2.3 3.6 11.0 -1.4 -0.8 1.0 -3.3
Hair/balding pattern: Pattern 2 3.1 3.9 11.8 -1.8 -0.7 -0.2 -3.4
Had menopause 1.1 1.4 2.6 1.2 1.6 0.8 1.0
Had other major operations 0.4 0.5 0.9 -0.9 -0.8 -0.3 -0.7
Forced vital capacity (FVC) 0.3 1.0 3.7 -1.9 0.1 0.6 0.2
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.4 1.0 -0.3 0.7 -1.0 0.1
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 1.3 -0.2 -0.7 1.2 0.3
Qualifications: None of the above 0.2 0.5 1.8 0.1 0.1 1.4 -0.3
Financial difficulties in last 2 years 0.8 1.0 1.8 -0.8 -0.5 1.2 -1.3
Mouth/teeth dental problems 0.4 0.6 1.1 -0.0 1.0 -0.6 1.0
Heart attack 0.6 0.8 2.0 0.8 1.4 0.5 0.2
Allergy 0.3 0.7 1.8 0.1 -0.9 1.3 0.6
Pain all over the body in last month 0.7 0.8 1.4 0.6 -1.1 -1.2 0.3
Diabetes (self-reported) 1.7 2.6 9.5 -0.7 -0.5 -3.1 0.3
Hayfever/allergic rhinitis (self-reported) 2.3 3.0 4.9 2.2 2.2 -0.1 1.5
Medication: Ramipril 1.3 1.7 4.3 1.1 0.5 -2.1 1.1
Medication: Simvastatin 0.5 0.8 1.9 0.9 0.3 -1.4 0.6
Fluid intelligence score 0.3 0.6 1.0 -1.0 -0.4 -0.6 -0.9
Illnesses of siblings 0.7 1.0 2.0 -0.9 -0.9 0.6 1.4
Neuroticism score 0.3 0.7 2.5 -0.4 -0.4 -0.3 -1.6
Weight 0.8 4.1 8.8 -0.7 -3.0 -0.2 -2.6
Impedance of arm (right) 0.0 0.2 0.3 0.5 -0.4 -0.5 0.3
Arm fat percentage (right) 0.5 2.0 3.7 0.6 -1.9 -1.3 -1.5
Trunk fat-free mass 0.7 3.9 5.6 -1.8 -2.4 1.4 -2.2
Hip circumference 1.2 5.0 10.3 -0.5 -3.2 -1.1 -2.9
Time employed in main current job 1.0 1.2 3.9 -0.0 2.0 0.4 0.8
Alcohol intake versus 10 years previously 0.9 1.3 2.8 1.5 0.5 -0.3 1.7
Father’s age at death 0.6 0.8 2.1 -0.7 -0.2 1.5 0.7
Worrier / anxious feelings 1.6 3.1 7.5 -1.7 -1.2 -0.5 -2.7
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.5 0.8 0.5 -0.8 -0.6 -0.9
Falls in the last year 0.3 0.4 0.9 0.3 -0.2 -1.0 0.6
Hair/balding pattern: Pattern 3 0.9 1.3 2.0 1.4 0.6 -1.1 1.3
Number of live births 1.2 1.7 5.3 0.6 -0.7 2.3 0.8
Forced expiratory volume in 1-second (FEV1) 0.3 0.9 2.3 -1.5 -0.4 1.1 -0.1
Pulse rate 0.4 0.7 1.0 1.0 0.9 0.7 -0.4
Happiness 2.0 2.4 5.4 -1.3 -1.3 1.0 -2.3
Noisy workplace 0.3 0.3 0.6 -0.7 -0.8 0.1 -0.4
Qualifications: A levels/AS levels or equivalent 0.1 0.2 0.8 0.1 -0.3 -0.0 -0.9
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.5 1.3 1.1 -0.1 -0.9 0.1
Mouth/teeth dental problems: Dentures 0.2 0.4 0.7 -0.5 0.3 -0.8 0.8
Asthma 0.5 1.0 3.1 0.1 1.8 0.1 1.0
Medication: Ibuprofen (e.g. Nurofen) 2.4 3.1 11.2 0.8 -0.4 3.3 -0.6
Medication: Cholesterol lowering 0.5 0.8 1.9 0.8 -0.3 -1.4 0.8
Depression (self-reported) 1.4 1.6 3.5 -1.2 -0.1 1.9 -1.3
Medication: Lansoprazole 0.2 0.2 0.9 -0.2 -0.9 -0.2 0.0
Prospective memory result 0.9 1.2 2.7 1.6 0.6 -0.1 1.2
Lung cancer (father) 1.4 1.7 3.1 -0.9 -1.1 -1.3 -1.8
Illnesses of mother 3.2 3.9 5.3 -1.6 2.3 -1.6 2.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.5 4.6 -2.1 -0.9 0.6 -0.4
Pulse wave Arterial Stiffness index 0.1 0.1 0.2 0.5 -0.2 -0.0 0.1
Impedance of arm (left) 0.0 0.2 0.5 0.7 0.0 -0.5 0.3
Arm fat mass (right) 0.7 2.8 5.9 -0.1 -2.4 -1.1 -2.0
Trunk predicted mass 0.7 3.9 5.6 -1.7 -2.4 1.4 -2.3
Standing height 0.8 7.6 12.0 -2.5 -3.5 1.6 -3.1
Length of working week for main job 1.1 1.2 2.1 0.7 1.0 1.1 1.5
Exposure to tobacco smoke at home 0.2 0.2 0.6 0.1 0.0 -0.8 -0.3
Breastfed as a baby 1.9 2.3 4.7 2.2 1.6 0.6 1.3
Tense / ‘highly strung’ 0.7 1.2 1.7 -0.5 -1.2 -1.3 -1.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.9 1.4 2.5 -1.4 -0.9 0.1 -1.6
Hair/balding pattern: Pattern 4 1.4 3.4 5.6 1.5 2.0 1.3 2.4
Birth weight of first child 0.5 0.8 3.0 0.2 0.4 -1.7 -0.3
Peak expiratory flow (PEF) 0.2 0.4 1.1 -0.8 0.2 1.0 0.2
Pulse wave reflection index 0.3 0.4 0.7 -0.4 -0.3 -0.8 0.7
Ever highly irritable/argumentative for 2 days 0.3 0.4 0.6 -0.8 -0.7 0.5 0.3
Loud music exposure frequency 0.3 0.4 0.9 -1.0 0.5 -0.0 -0.5
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 0.6 -0.4 -0.4 -0.8 -0.5
Mouth/teeth dental problems: Bleeding gums 1.1 1.4 2.8 -0.3 -1.2 1.0 -1.7
Blood clot in the leg (DVT) 1.6 2.0 3.2 -1.0 -1.5 -1.3 -1.8
Medication: Paracetamol 0.4 0.7 2.6 0.2 -0.3 1.6 0.3
Headache pain in last month 0.1 0.1 0.2 0.1 0.5 -0.5 0.2
Medication for cholesterol, blood pressure or diabetes 0.4 0.6 1.5 0.4 1.2 0.8 0.1
Glaucoma (self-reported) 0.9 1.1 3.6 -0.1 -0.7 -1.9 -0.3
Gout (self-reported) 0.4 0.6 1.3 0.7 -0.1 1.1 -0.7
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 0.6 0.7 0.5 -0.8 -0.6
Medication: Amlodipine 1.5 2.0 5.3 -0.3 -2.3 -1.3 -1.0
Medication: Ventolin 100micrograms inhaler 0.9 1.2 3.2 0.9 1.8 -0.3 0.7
Birth weight 1.6 3.5 9.4 -3.1 -1.5 0.5 -1.4
Chronic bronchitis/emphysema (mother) 3.5 4.0 7.3 2.7 2.2 -1.3 1.5
High blood pressure (siblings) 0.7 1.0 1.7 1.0 1.1 -0.6 -1.3
Forced vital capacity (FVC), Best measure 0.5 1.9 7.3 -2.7 -0.4 0.4 -0.1
Body fat percentage 0.6 2.3 4.6 0.8 -2.2 -1.1 -1.7
Leg fat percentage (right) 0.3 1.1 2.4 1.0 -1.5 0.4 -1.0
Arm fat-free mass (right) 0.8 4.3 7.3 -1.6 -2.5 0.9 -2.7
Exposure to tobacco smoke outside home 0.1 0.2 0.2 0.5 -0.5 0.5 -0.1
Comparative body size at age 10 1.0 2.8 10.0 3.2 0.3 0.6 0.8
Number of full brothers 1.2 1.5 3.3 1.5 0.5 -1.8 0.5
Worry too long after embarrassment 0.9 1.6 4.2 0.0 -1.3 0.5 -2.1
Seen a psychiatrist for nerves, anxiety, tension or depression 1.8 2.4 3.7 -1.5 0.3 -1.8 -1.9
Wheeze or whistling in the chest in last year 0.2 0.3 0.7 -0.8 -0.1 0.5 -0.7
Number of children fathered 2.0 2.2 3.7 -0.2 -1.6 1.9 -1.7
Reason for reducing amount of alcohol drunk: Health precaution 1.5 1.7 3.7 1.9 -1.2 -0.4 1.3
Age at first live birth 0.4 0.7 1.5 -0.5 -0.1 -1.0 -1.2
Pulse wave peak to peak time 0.2 0.2 0.6 -0.8 -0.1 0.2 -0.6
Health satisfaction 1.0 1.2 2.9 -0.5 -1.7 0.3 -1.3
Shortness of breath walking on level ground 0.6 0.7 1.1 0.5 -0.8 1.0 0.9
Qualifications: College or University degree 0.3 0.9 1.7 -1.2 -0.4 -1.3 0.2
Eye problems/disorders: None of the above 0.1 0.2 0.3 -0.4 -0.6 -0.4 -0.0
Mouth/teeth dental problems: Loose teeth 0.9 1.0 2.4 -1.5 -0.8 0.7 -0.8
Emphysema/chronic bronchitis 0.3 0.3 0.7 -0.6 0.3 0.3 -0.9
Medication for pain relief, constipation, heartburn 0.2 0.4 1.1 -0.7 0.2 -1.0 -0.2
Neck or shoulder pain in last month 0.5 0.8 1.7 -0.3 1.0 1.3 -0.5
Medication: Blood pressure 0.6 1.1 2.5 -0.4 -1.6 -0.5 -1.3
Angina (self-reported) 0.8 1.1 2.3 0.7 0.8 -1.5 0.9
Migraine (self-reported) 2.1 2.6 4.6 -2.1 -1.1 -0.4 -2.1
Medication: Ibuprofen 1.8 2.1 7.0 0.1 -1.0 2.6 -0.7
Medication: Allopurinol 0.9 1.2 3.8 -0.3 -0.5 2.0 -0.8
Medication: Omeprazole 0.2 0.3 0.8 -0.9 -0.5 0.1 0.3
Medication: Seretide 50 evohaler 2.3 2.7 3.8 -2.0 -1.6 -1.9 -1.0
Mean time to correctly identify matches 0.4 0.7 1.8 -0.7 -1.3 -0.3 -0.6
Heart disease (mother) 1.0 1.2 3.3 1.8 -0.1 1.1 -0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.0 1.1 1.7 -1.1 0.8 -1.0 -1.3
Whole body fat mass 0.7 2.9 6.5 0.1 -2.5 -0.8 -2.1
Leg fat mass (right) 0.7 2.7 6.8 0.0 -2.6 -0.1 -2.0
Arm predicted mass (right) 0.8 4.2 7.1 -1.6 -2.6 0.5 -2.7
Pulse rate, automated reading 0.5 1.5 2.5 1.4 0.9 1.6 0.9
Alcohol intake frequency. 0.1 0.2 0.6 0.1 -0.2 -0.8 0.2
Comparative height size at age 10 0.1 0.4 0.7 0.2 -0.7 0.9 -0.3
Number of full sisters 2.7 3.3 8.6 1.3 1.4 -0.9 2.9
Suffer from ‘nerves’ 0.4 0.6 1.2 -0.2 -1.0 -1.1 -0.5
Overall health rating 0.8 1.8 3.6 -0.2 -1.8 -0.2 -1.9
Chest pain or discomfort 0.3 0.5 0.9 -0.5 -0.2 -0.9 -0.9
Had major operations 0.5 0.6 1.3 -0.2 0.9 1.1 -0.5
Age at last live birth 0.1 0.1 0.1 -0.3 -0.4 0.1 -0.3
Family relationship satisfaction 0.8 1.0 2.6 -0.1 -1.6 0.2 -1.2
Leg pain on walking 0.9 1.1 2.7 -0.1 -1.0 1.6 -0.9
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.4 0.7 0.1 -0.3 0.8 -0.8
Commuting to job workplace: Car/motor vehicle 1.0 1.1 3.7 -0.1 -0.0 0.8 1.9
Illness, injury, bereavement, stress in last 2 years 0.7 0.8 2.5 -1.6 -0.4 -0.7 -0.5
Medication: Aspirin 0.6 0.8 2.1 1.1 0.1 -1.5 0.2
Supplements: Vitamin C 2.9 3.4 7.7 -1.2 -2.8 -0.6 -2.1
Knee pain experienced in last month 1.5 2.3 4.6 -2.1 0.2 1.2 -1.8
Hypertension (Self-reported) 0.1 0.2 0.3 0.5 0.5 -0.3 -0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.3 0.8 0.5 -0.9 -0.1 0.0
Illnesses of father: Heart disease 0.2 0.2 0.5 -0.7 -0.5 0.3 0.1
Illnesses of siblings: Diabetes 0.2 0.2 0.5 0.3 0.7 -0.6 -0.1
Smoking status: Previous 1.4 2.1 3.5 1.4 0.7 1.5 1.9
Forced expiratory volume in 1-second (FEV1), predicted 1.0 2.1 2.6 -1.4 -1.6 -1.6 -1.2
Whole body fat-free mass 0.8 4.6 7.7 -1.8 -2.8 0.7 -2.6
Leg fat-free mass (right) 1.0 5.2 9.2 -1.7 -3.0 -0.5 -3.0
Arm fat percentage (left) 0.5 2.0 3.3 0.9 -1.8 -1.4 -1.5
Average weekly red wine intake 0.2 0.3 0.5 -0.7 -0.7 -0.2 -0.5
Handedness (chirality/laterality): Left-handed 0.5 0.6 1.2 1.0 0.4 1.1 0.4
Mood swings 0.3 0.5 1.0 -0.4 0.5 -0.7 -1.0
Loneliness, isolation 0.4 0.6 1.0 0.0 -1.0 0.9 -0.8
Long-standing illness, disability or infirmity 0.1 0.2 0.3 -0.3 -0.4 0.3 -0.5
Ever had bowel cancer screening 1.3 1.5 2.6 -1.2 -1.6 0.8 -1.1
Diabetes diagnosed by doctor 1.8 2.9 10.6 -0.8 -0.6 -3.3 -0.3
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.7 1.1 1.1 -0.9 1.0 0.0
Friendships satisfaction 0.4 0.5 1.3 -0.6 -0.1 -0.6 -1.2
Qualifications: nursing, teaching 3.2 4.9 9.6 2.2 1.6 -1.6 3.1
Commuting to job workplace: Walk 2.3 2.4 4.6 1.2 2.1 -1.6 1.1
Eye problems/disorders: Cataract 0.3 0.3 0.7 0.6 0.8 0.4 -0.0
Mouth/teeth dental problems: Mouth ulcers 2.0 3.2 5.5 -1.5 -2.3 0.2 -2.3
Medication for cholesterol 0.9 1.3 2.9 1.0 -1.7 -1.1 0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.9 1.1 2.6 -0.6 1.6 -0.6 1.0
Back pain experienced in last month 0.2 0.3 0.7 0.9 0.6 0.3 0.3
Mineral and other dietary supplements 0.3 0.4 0.8 0.8 -0.1 -0.1 0.9
Breast cancer (self-reported) 0.6 0.7 1.6 -0.7 -1.3 -0.2 -0.9
Asthma (self-reported) 0.7 1.4 3.6 0.3 1.9 0.2 1.4
Osteoporosis (self-reported) 1.3 1.6 3.9 0.4 -1.4 2.0 -0.7
Osteoarthritis (self-reported) 0.6 0.8 1.7 -0.5 1.3 1.1 -0.3
Medication: Aspirin 0.4 0.6 1.7 0.7 -0.3 -1.3 0.1
Medication: Gliclazide 5.3 6.0 18.7 0.6 1.0 -4.3 2.0
Illnesses of father: None of the above (group 1) 1.1 1.4 2.9 -1.7 -0.8 -0.8 -1.1
Smoking status: Current 0.3 0.5 1.2 0.2 0.5 1.1 0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.0 2.1 6.6 -2.6 -1.2 -0.0 -0.6
Whole body water mass 0.8 4.4 7.1 -1.8 -2.7 0.7 -2.6
Leg predicted mass (right) 0.9 4.9 8.8 -1.6 -3.0 -0.3 -2.8
Arm fat mass (left) 0.7 3.0 5.4 -0.0 -2.3 -1.3 -2.2
Number of self-reported non-cancer illnesses 0.3 0.4 0.9 0.7 0.9 0.6 -0.1
Average weekly champagne plus white wine intake 0.3 0.4 0.8 -0.7 0.9 -0.5 -0.5
Miserableness 0.3 0.6 1.6 -0.6 0.3 0.4 -1.3
Guilty feelings 1.9 2.9 5.4 -1.8 -1.7 -0.1 -2.3
Wears glasses or contact lenses 1.6 1.8 3.3 1.8 1.4 1.1 0.9
Ever taken oral contraceptive pill 0.6 0.6 1.0 0.5 0.7 -0.8 1.0
Hearing aid user 0.5 0.6 1.5 0.3 1.2 0.9 -0.0
Mother’s age at death 1.5 1.8 2.7 1.3 1.6 1.4 1.0
Financial situation satisfaction 0.2 0.2 0.8 -0.1 0.2 0.9 -0.4
Tinnitus: Yes, now most or all of the time 0.8 0.9 2.5 0.0 1.1 0.0 1.6
Commuting to job workplace: Public transport 1.4 1.7 4.1 1.3 0.2 -2.0 -0.9
Eye problems/disorders: Glaucoma 0.1 0.2 0.3 -0.2 0.4 -0.5 0.5
Medication: Blood pressure 0.5 1.0 2.7 0.6 1.6 0.9 0.4
Pain type(s) experienced in last month: Hip pain 0.2 0.2 0.5 0.3 -0.3 -0.4 -0.7
Supplements: Fish oil (including cod liver oil) 0.3 0.4 0.6 -0.8 -0.3 0.6 -0.8
High cholesterol (Self-reported) 1.6 2.9 3.4 1.9 1.4 -1.7 1.8
Medication: Bendroflumethiazide 0.8 1.2 2.3 -1.5 0.2 0.9 -1.4
Medication: Paracetamol 0.7 1.1 4.3 0.2 0.2 2.1 0.4
Medication: Lisinopril 0.1 0.1 0.4 -0.0 0.3 0.6 0.0
Medication: Atorvastatin 0.8 1.0 2.4 1.5 1.1 -0.3 0.6
Illnesses of father: High blood pressure 1.1 1.4 3.4 1.9 0.7 0.2 1.3
Alcohol drinker status: Never 1.1 1.3 3.8 -1.9 0.1 -0.1 1.2
Ever smoked 1.2 2.1 4.1 0.8 1.0 1.6 2.0
Basal metabolic rate 0.9 5.1 8.9 -1.7 -3.0 0.5 -2.9
Leg fat percentage (left) 0.3 1.1 1.5 1.1 -1.2 -0.3 -1.2
Arm fat-free mass (left) 1.0 5.1 8.7 -2.0 -2.7 0.5 -3.0
Number of operations (self-reported) 1.6 2.4 8.1 -0.3 0.9 2.8 0.7
Average weekly beer plus cider intake 0.4 0.6 1.1 0.5 -0.7 0.7 -1.0
Irritability 0.8 1.3 2.0 1.4 1.3 -1.3 0.1
Risk taking 0.3 0.5 1.1 -0.6 0.1 -0.7 1.0
Ever had prostate specific antigen (PSA) test 0.5 0.5 2.0 -1.4 0.3 -0.0 -0.3
Fractured/broken bones in last 5 years 0.1 0.1 0.4 -0.1 -0.3 -0.0 -0.6
Age started oral contraceptive pill 1.7 2.2 5.1 -1.2 -0.2 -1.5 -2.3
Diastolic blood pressure, automated reading 0.3 1.1 2.3 1.5 1.2 0.7 0.1
Ever depressed for a whole week 0.1 0.1 0.4 0.1 0.1 0.7 -0.2
Unable to work because of sickness or disability 0.2 0.3 0.6 -0.8 -0.2 -0.2 -0.5
Commuting to job workplace: Cycle 0.5 0.6 1.6 -0.2 0.5 -0.7 -1.3
Myopia 1.2 1.8 2.7 -1.3 -1.0 -1.6 -1.4
Vascular/heart problems diagnosed by doctor 0.1 0.4 1.3 -1.1 -0.6 -0.1 -0.0
Cholesterol lowering medication 0.4 0.5 1.7 0.4 1.3 0.1 0.5
Medication: Omeprazole (e.g. Zanprol) 0.1 0.1 0.4 0.0 0.1 -0.6 0.4
Pain experienced in last month 0.1 0.2 0.2 0.5 -0.4 -0.3 0.5
Supplements: Calcium 0.3 0.3 0.7 0.3 0.1 -0.9 -0.7
Basal cell carcinoma (self-reported) 1.7 2.0 3.5 -1.9 -1.4 1.2 -1.1
Heart attack/myocardial infarction (self-reported) 0.9 1.1 3.0 0.9 1.7 0.5 0.5
Deep venous thrombosis (DVT) (self-reported) 1.6 2.1 3.3 -1.0 -1.4 -1.4 -1.8
Heart disease (siblings) 0.7 0.8 1.4 0.9 0.1 1.0 -1.2
Alcohol drinker status: Previous 1.8 2.0 2.5 -1.1 -1.6 -1.5 -1.5
Pack years of smoking 2.0 2.9 5.0 -1.3 -1.9 -1.1 -2.2
Impedance of whole body 0.0 0.1 0.2 0.3 -0.0 -0.4 0.2
Leg fat mass (left) 0.6 2.3 5.0 0.1 -2.2 -0.5 -2.0
Arm predicted mass (left) 0.8 4.0 6.9 -1.8 -2.4 0.6 -2.6