Hub : Genes

NRIP2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.112	0.0310	1.1e-04	-0.002	0.040	0.002	0.035	0.002	0.7300	1.0e-05	1.5e-01	3.5e-05	1.7e-01
2	GTEx	Brain Putamen basal ganglia	0.479	0.1320	1.2e-03	0.069	NA	0.213	NA	0.201	0.0100	NA	8.8e-06	NA	1.6e-05
3	GTEx	Skin Sun Exposed Lower leg	0.172	0.0600	5.3e-03	0.003	NA	-0.002	NA	-0.003	0.1900	NA	6.1e-01	NA	8.7e-01
4	ROSMAP	Brain Pre-frontal Cortex	0.140	0.0332	4.5e-08	0.018	0.054	0.058	0.064	0.056	0.0021	1.6e-07	5.0e-08	1.1e-08	8.6e-08

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.5	0.8	2.1	-0.3	0.9	-0.6	1.4
Bipolar Disorder or Schizophrenia	0.7	1.7	2.3	-1.0	1.0	-1.5	1.5
Depressed Affect (Nagel 2018)	0.3	0.6	2.3	0.1	1.5	0.4	-0.3
Depression (Nagel 2018)	0.7	1.0	2.6	0.3	1.6	0.7	0.9
Intelligence (Savage-Jansen 2018)	0.4	1.1	1.8	-0.5	-1.3	-1.3	-0.9
Neuroticism (Nagel 2018)	0.2	0.6	1.6	-0.6	0.1	0.5	-1.3
Schizophrenia (2018)	0.5	1.1	1.9	-1.1	0.6	-1.4	0.8
Schizophrenia vs Biploar Disorder	0.6	0.7	1.4	-0.8	-0.9	-1.2	-0.4
Worry (Nagel 2018)	0.6	1.3	2.5	-1.5	-0.6	-0.0	-1.6
Alzheimer’s Disease (in mother)	0.2	0.2	0.3	-0.3	-0.3	-0.5	-0.6
Alzheimer’s Disease (in father)	0.5	0.6	2.1	-0.4	-0.0	-1.5	-0.2
Alzheimer’s Disease (including proxy)	1.1	1.6	3.5	-1.0	-0.8	-1.9	-1.1
Crohns Disease (2017)	1.1	2.4	4.9	-0.7	-2.2	1.7	-1.2
Irritable Bowel Disease (IBD)	0.3	0.8	1.3	1.0	-0.9	1.1	0.2
Ulcerative Colitis (UC)	0.5	1.0	2.7	1.6	0.2	0.7	0.8
Major Depression (MDD)	0.1	0.2	0.3	-0.3	0.2	-0.6	-0.4
Reaction Time	0.8	1.4	2.5	-1.2	-1.6	-0.1	-1.4
Verbal and Numeric Reasoning (VNR)	0.4	1.0	2.0	-1.4	-1.0	-0.2	-0.9
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	0.8	1.0	2.9	0.1	1.1	-0.1	1.7
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.2	0.3	1.0	-0.4	1.0	-0.2	0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.6	0.9	3.1	0.2	0.5	1.8	-0.0
Coronary Artery Disease (CAD)	0.5	0.6	1.1	-0.9	1.1	-0.3	0.7
Crohns Disease (2012)	1.4	2.3	4.0	-0.9	-2.0	1.5	-1.5
Mean Putamen Volume	2.4	2.8	6.4	-2.0	-0.5	0.7	-2.5
Fasting Glucose	2.2	2.7	5.7	-2.4	1.5	0.6	-1.6
HbA1C	1.7	1.9	4.1	-1.6	0.9	2.0	-0.3
HDL Cholesterol	0.4	0.6	2.3	0.1	-0.5	-1.5	0.1
LDL Cholesterol	0.0	0.0	0.0	-0.0	0.1	-0.1	0.1
Lupus	0.7	1.1	2.7	-0.4	-1.6	-1.2	0.3
Neuroticism (2016)	0.6	0.8	1.9	-0.4	-0.0	-1.1	-1.4
Primary Biliary Cirrhosis	0.4	0.6	1.9	0.5	-1.4	-0.1	-0.5
Rheumatoid Arthritis	1.1	1.5	5.1	-0.5	-0.7	2.3	0.0
Schizophrenia (2014)	0.7	1.5	2.8	-0.4	0.9	-1.4	1.7
Triglycerides	0.2	0.3	0.7	-0.4	-0.4	0.3	-0.8
Type 2 Diabetes (T2D) (2012)	1.6	1.8	3.3	0.8	1.0	1.5	1.8
Ulcerative Colitis	0.5	0.8	1.8	1.3	-0.1	0.3	1.1
Blood Eosinophil Count	0.1	0.8	2.6	1.6	-0.4	-0.2	0.7
Blood Platelet Count	0.2	2.1	5.7	-0.4	1.3	0.9	2.4
Blood Red Count	0.4	3.6	7.3	1.7	-0.3	2.7	-2.0
Blood White Count	0.6	4.5	8.9	1.5	2.4	1.0	3.0
Heel T-Score	0.4	3.0	8.9	-1.1	1.2	-3.0	-0.7
BMI	0.2	1.2	2.0	1.2	-1.4	-0.2	-1.2
Height	0.8	15.2	27.7	-2.2	-5.3	3.3	-4.2
Waist Hip Ratio (WHR)	0.4	1.8	4.5	0.6	0.5	2.1	1.5
Systolic Blood Pressure	0.2	0.8	1.6	1.0	1.3	-0.7	-0.5
Smoking Status	1.0	2.3	5.1	1.1	0.7	2.3	1.6
Allergy or Eczema	0.1	0.3	0.6	0.8	0.1	-0.6	-0.1
Cardiovascular Disease	0.3	0.8	2.3	1.5	0.6	-0.7	0.3
Hypothyroidism (self reported)	0.2	0.3	0.5	0.7	0.5	-0.6	-0.6
Respiratory disease	0.3	0.7	1.2	0.6	1.0	0.6	1.1
Type 2 Diabetes (T2D) (2018)	1.4	2.7	8.5	-0.7	-0.9	-2.9	-0.9
Lung FEV1/FVC ratio	0.6	3.2	8.4	-0.5	-1.7	2.9	-1.1
Lung FVC	0.7	3.8	6.6	-2.1	2.0	0.5	2.6
Neuroticism	0.0	0.1	0.3	-0.1	-0.1	0.2	-0.5
Chronotype (morning person)	0.9	2.1	4.7	1.1	0.7	-2.2	1.3
Hair Pigment	0.0	0.7	2.1	-0.5	-1.4	-0.0	-0.6
Tanning	0.1	1.2	4.4	-2.1	-0.6	0.2	-0.3
Hand grip strength (left)	0.4	1.1	2.7	-1.6	-0.5	1.1	0.3
Number of treatments/medications taken	0.1	0.2	0.7	0.0	0.3	0.8	0.0
Average weekly spirits intake	0.8	1.0	2.3	0.8	1.5	0.3	1.1
Sensitivity / hurt feelings	0.7	1.1	3.7	0.9	-0.0	1.9	-0.2
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.9	-0.1	0.9	0.5	-0.2
Hearing difficulty/problems: Yes	1.7	2.5	6.3	-0.7	-0.9	1.6	-2.5
Relative age of first facial hair	0.0	0.0	0.1	-0.3	0.2	0.2	0.1
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.9	0.5	-0.2	1.7	-0.1
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.8	-0.8	-0.1	0.2	-1.3
Ever had hysterectomy (womb removed)	0.9	1.0	2.5	1.0	0.0	1.6	0.8
Systolic blood pressure, automated reading	0.2	0.7	1.2	0.9	1.1	-0.8	0.0
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	4.2	-0.0	-0.6	-2.0	-0.6
Angina	0.4	0.6	1.1	0.4	0.7	-1.0	0.7
Medication for hormone replacement therapy	0.9	1.0	3.8	-1.9	0.3	0.0	-0.4
Vitamin and mineral supplements	1.2	1.6	3.1	1.1	1.8	-1.2	0.8
Supplements: Zinc	0.2	0.2	0.5	-0.4	0.1	-0.3	-0.7
Medication: Co-codamol	2.7	3.1	6.5	2.5	1.2	-1.4	1.6
Medication: Metformin	0.6	0.9	3.2	0.2	-0.1	-1.8	0.5
Diabetes (father)	1.6	2.0	2.7	1.6	1.0	-1.3	1.7
Diabetes (mother)	1.3	1.7	5.9	-0.2	-2.4	-0.6	-0.8
Severe depression (siblings)	0.7	0.8	1.6	-1.3	-1.1	-0.3	-0.5
Pack years adult smoking proportion	1.4	2.2	3.7	-1.1	-1.5	-1.3	-1.9
Impedance of leg (right)	0.2	0.8	2.1	0.6	0.3	1.5	0.8
Leg fat-free mass (left)	1.0	5.3	10.7	-1.7	-3.3	-0.1	-2.8
Trunk fat percentage	0.8	3.4	6.5	0.6	-2.5	-1.3	-2.2
Hand grip strength (right)	1.1	3.1	6.4	-2.5	-1.4	1.7	-1.1
Townsend deprivation index at recruitment	2.1	2.9	4.9	-0.7	-2.0	-2.2	-1.5
Current tobacco smoking	0.4	0.6	1.2	0.3	1.0	1.1	0.6
Average weekly fortified wine intake	1.2	1.4	3.0	-0.6	-1.4	0.5	-1.7
Maternal smoking around birth	0.8	1.1	2.3	-0.4	-1.1	-0.8	-1.5
Fed-up feelings	0.4	0.7	2.6	0.4	1.6	-0.3	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.6	-0.1	0.7	0.0	0.7
Relative age voice broke	0.4	0.6	1.8	-0.1	1.3	-0.4	0.6
Taking other prescription medications	0.3	0.4	1.2	-0.3	-0.3	-0.6	-1.1
Age when periods started (menarche)	0.3	0.8	2.0	-0.4	-0.9	-0.3	-1.4
Bilateral oophorectomy (both ovaries removed)	1.7	2.0	3.3	1.2	1.8	0.6	1.6
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.1	-0.7	0.6	-1.1	-0.9
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.4	0.4	0.1	1.2	-0.7
Qualifications: CSEs or equivalent	0.4	0.5	1.0	-0.2	-0.7	-0.7	-1.0
Serious illness, injury or assault to yourself	0.1	0.1	0.4	0.6	-0.2	-0.1	0.1
High blood pressure	0.1	0.2	0.4	0.6	0.4	-0.1	-0.1
Hayfever, allergic rhinitis or eczema	0.1	0.1	0.3	-0.1	0.1	-0.6	-0.4
Multivitamins +/- minerals	1.4	1.8	4.7	-1.1	-0.8	2.2	-0.7
Stomach or abdominal pain in last month	1.0	1.2	3.5	-0.4	-1.1	-0.1	-1.9
Supplements: Glucosamine	0.5	0.7	1.9	-0.2	-0.8	0.2	-1.4
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	1.7	-0.2	-1.2	-0.4	-1.3
Medication: Atenolol	0.7	0.9	2.1	-0.7	-0.7	-1.4	-0.9
Medication: Levothyroxine sodium	0.5	0.9	2.9	1.7	0.6	-0.5	0.1
Sitting height	0.8	5.4	12.1	-1.8	-2.4	0.6	-3.5
Chronic bronchitis/emphysema (father)	2.8	3.3	5.6	2.4	1.8	0.3	2.0
High blood pressure (mother)	0.7	1.0	2.5	0.8	-1.6	0.7	-0.5
Body mass index (BMI)	0.3	1.4	2.5	0.4	-1.6	-1.0	-1.3
Impedance of leg (left)	0.1	0.3	0.3	0.6	0.6	0.4	0.5
Leg predicted mass (left)	1.1	5.7	11.2	-1.8	-3.3	-0.0	-2.9
Trunk fat mass	0.9	3.9	8.3	0.1	-2.9	-0.9	-2.5
Waist circumference	0.4	1.5	3.4	0.5	-1.8	-0.2	-1.5
Number of incorrect matches in round	0.1	0.1	0.2	-0.2	-0.4	-0.2	-0.4
Past tobacco smoking	1.3	2.5	4.6	-1.3	-0.7	-1.8	-2.2
Alcohol usually taken with meals	0.6	1.0	1.8	1.3	0.9	0.4	1.0
Nervous feelings	0.6	1.0	1.3	-1.1	-1.1	-0.6	-1.1
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.4	0.9	0.2	0.9	-0.7	0.3
Hearing difficulty/problems with background noise	2.3	3.6	11.0	-1.4	-0.8	1.0	-3.3
Hair/balding pattern: Pattern 2	3.1	3.9	11.8	-1.8	-0.7	-0.2	-3.4
Had menopause	1.1	1.4	2.6	1.2	1.6	0.8	1.0
Had other major operations	0.4	0.5	0.9	-0.9	-0.8	-0.3	-0.7
Forced vital capacity (FVC)	0.3	1.0	3.7	-1.9	0.1	0.6	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.0	-0.3	0.7	-1.0	0.1
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.3	-0.2	-0.7	1.2	0.3
Qualifications: None of the above	0.2	0.5	1.8	0.1	0.1	1.4	-0.3
Financial difficulties in last 2 years	0.8	1.0	1.8	-0.8	-0.5	1.2	-1.3
Mouth/teeth dental problems	0.4	0.6	1.1	-0.0	1.0	-0.6	1.0
Heart attack	0.6	0.8	2.0	0.8	1.4	0.5	0.2
Allergy	0.3	0.7	1.8	0.1	-0.9	1.3	0.6
Pain all over the body in last month	0.7	0.8	1.4	0.6	-1.1	-1.2	0.3
Diabetes (self-reported)	1.7	2.6	9.5	-0.7	-0.5	-3.1	0.3
Hayfever/allergic rhinitis (self-reported)	2.3	3.0	4.9	2.2	2.2	-0.1	1.5
Medication: Ramipril	1.3	1.7	4.3	1.1	0.5	-2.1	1.1
Medication: Simvastatin	0.5	0.8	1.9	0.9	0.3	-1.4	0.6
Fluid intelligence score	0.3	0.6	1.0	-1.0	-0.4	-0.6	-0.9
Illnesses of siblings	0.7	1.0	2.0	-0.9	-0.9	0.6	1.4
Neuroticism score	0.3	0.7	2.5	-0.4	-0.4	-0.3	-1.6
Weight	0.8	4.1	8.8	-0.7	-3.0	-0.2	-2.6
Impedance of arm (right)	0.0	0.2	0.3	0.5	-0.4	-0.5	0.3
Arm fat percentage (right)	0.5	2.0	3.7	0.6	-1.9	-1.3	-1.5
Trunk fat-free mass	0.7	3.9	5.6	-1.8	-2.4	1.4	-2.2
Hip circumference	1.2	5.0	10.3	-0.5	-3.2	-1.1	-2.9
Time employed in main current job	1.0	1.2	3.9	-0.0	2.0	0.4	0.8
Alcohol intake versus 10 years previously	0.9	1.3	2.8	1.5	0.5	-0.3	1.7
Father’s age at death	0.6	0.8	2.1	-0.7	-0.2	1.5	0.7
Worrier / anxious feelings	1.6	3.1	7.5	-1.7	-1.2	-0.5	-2.7
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	0.8	0.5	-0.8	-0.6	-0.9
Falls in the last year	0.3	0.4	0.9	0.3	-0.2	-1.0	0.6
Hair/balding pattern: Pattern 3	0.9	1.3	2.0	1.4	0.6	-1.1	1.3
Number of live births	1.2	1.7	5.3	0.6	-0.7	2.3	0.8
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	2.3	-1.5	-0.4	1.1	-0.1
Pulse rate	0.4	0.7	1.0	1.0	0.9	0.7	-0.4
Happiness	2.0	2.4	5.4	-1.3	-1.3	1.0	-2.3
Noisy workplace	0.3	0.3	0.6	-0.7	-0.8	0.1	-0.4
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.8	0.1	-0.3	-0.0	-0.9
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	1.3	1.1	-0.1	-0.9	0.1
Mouth/teeth dental problems: Dentures	0.2	0.4	0.7	-0.5	0.3	-0.8	0.8
Asthma	0.5	1.0	3.1	0.1	1.8	0.1	1.0
Medication: Ibuprofen (e.g. Nurofen)	2.4	3.1	11.2	0.8	-0.4	3.3	-0.6
Medication: Cholesterol lowering	0.5	0.8	1.9	0.8	-0.3	-1.4	0.8
Depression (self-reported)	1.4	1.6	3.5	-1.2	-0.1	1.9	-1.3
Medication: Lansoprazole	0.2	0.2	0.9	-0.2	-0.9	-0.2	0.0
Prospective memory result	0.9	1.2	2.7	1.6	0.6	-0.1	1.2
Lung cancer (father)	1.4	1.7	3.1	-0.9	-1.1	-1.3	-1.8
Illnesses of mother	3.2	3.9	5.3	-1.6	2.3	-1.6	2.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	4.6	-2.1	-0.9	0.6	-0.4
Pulse wave Arterial Stiffness index	0.1	0.1	0.2	0.5	-0.2	-0.0	0.1
Impedance of arm (left)	0.0	0.2	0.5	0.7	0.0	-0.5	0.3
Arm fat mass (right)	0.7	2.8	5.9	-0.1	-2.4	-1.1	-2.0
Trunk predicted mass	0.7	3.9	5.6	-1.7	-2.4	1.4	-2.3
Standing height	0.8	7.6	12.0	-2.5	-3.5	1.6	-3.1
Length of working week for main job	1.1	1.2	2.1	0.7	1.0	1.1	1.5
Exposure to tobacco smoke at home	0.2	0.2	0.6	0.1	0.0	-0.8	-0.3
Breastfed as a baby	1.9	2.3	4.7	2.2	1.6	0.6	1.3
Tense / ‘highly strung’	0.7	1.2	1.7	-0.5	-1.2	-1.3	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	2.5	-1.4	-0.9	0.1	-1.6
Hair/balding pattern: Pattern 4	1.4	3.4	5.6	1.5	2.0	1.3	2.4
Birth weight of first child	0.5	0.8	3.0	0.2	0.4	-1.7	-0.3
Peak expiratory flow (PEF)	0.2	0.4	1.1	-0.8	0.2	1.0	0.2
Pulse wave reflection index	0.3	0.4	0.7	-0.4	-0.3	-0.8	0.7
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.6	-0.8	-0.7	0.5	0.3
Loud music exposure frequency	0.3	0.4	0.9	-1.0	0.5	-0.0	-0.5
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.6	-0.4	-0.4	-0.8	-0.5
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	2.8	-0.3	-1.2	1.0	-1.7
Blood clot in the leg (DVT)	1.6	2.0	3.2	-1.0	-1.5	-1.3	-1.8
Medication: Paracetamol	0.4	0.7	2.6	0.2	-0.3	1.6	0.3
Headache pain in last month	0.1	0.1	0.2	0.1	0.5	-0.5	0.2
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	1.5	0.4	1.2	0.8	0.1
Glaucoma (self-reported)	0.9	1.1	3.6	-0.1	-0.7	-1.9	-0.3
Gout (self-reported)	0.4	0.6	1.3	0.7	-0.1	1.1	-0.7
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.6	0.7	0.5	-0.8	-0.6
Medication: Amlodipine	1.5	2.0	5.3	-0.3	-2.3	-1.3	-1.0
Medication: Ventolin 100micrograms inhaler	0.9	1.2	3.2	0.9	1.8	-0.3	0.7
Birth weight	1.6	3.5	9.4	-3.1	-1.5	0.5	-1.4
Chronic bronchitis/emphysema (mother)	3.5	4.0	7.3	2.7	2.2	-1.3	1.5
High blood pressure (siblings)	0.7	1.0	1.7	1.0	1.1	-0.6	-1.3
Forced vital capacity (FVC), Best measure	0.5	1.9	7.3	-2.7	-0.4	0.4	-0.1
Body fat percentage	0.6	2.3	4.6	0.8	-2.2	-1.1	-1.7
Leg fat percentage (right)	0.3	1.1	2.4	1.0	-1.5	0.4	-1.0
Arm fat-free mass (right)	0.8	4.3	7.3	-1.6	-2.5	0.9	-2.7
Exposure to tobacco smoke outside home	0.1	0.2	0.2	0.5	-0.5	0.5	-0.1
Comparative body size at age 10	1.0	2.8	10.0	3.2	0.3	0.6	0.8
Number of full brothers	1.2	1.5	3.3	1.5	0.5	-1.8	0.5
Worry too long after embarrassment	0.9	1.6	4.2	0.0	-1.3	0.5	-2.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.8	2.4	3.7	-1.5	0.3	-1.8	-1.9
Wheeze or whistling in the chest in last year	0.2	0.3	0.7	-0.8	-0.1	0.5	-0.7
Number of children fathered	2.0	2.2	3.7	-0.2	-1.6	1.9	-1.7
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.7	3.7	1.9	-1.2	-0.4	1.3
Age at first live birth	0.4	0.7	1.5	-0.5	-0.1	-1.0	-1.2
Pulse wave peak to peak time	0.2	0.2	0.6	-0.8	-0.1	0.2	-0.6
Health satisfaction	1.0	1.2	2.9	-0.5	-1.7	0.3	-1.3
Shortness of breath walking on level ground	0.6	0.7	1.1	0.5	-0.8	1.0	0.9
Qualifications: College or University degree	0.3	0.9	1.7	-1.2	-0.4	-1.3	0.2
Eye problems/disorders: None of the above	0.1	0.2	0.3	-0.4	-0.6	-0.4	-0.0
Mouth/teeth dental problems: Loose teeth	0.9	1.0	2.4	-1.5	-0.8	0.7	-0.8
Emphysema/chronic bronchitis	0.3	0.3	0.7	-0.6	0.3	0.3	-0.9
Medication for pain relief, constipation, heartburn	0.2	0.4	1.1	-0.7	0.2	-1.0	-0.2
Neck or shoulder pain in last month	0.5	0.8	1.7	-0.3	1.0	1.3	-0.5
Medication: Blood pressure	0.6	1.1	2.5	-0.4	-1.6	-0.5	-1.3
Angina (self-reported)	0.8	1.1	2.3	0.7	0.8	-1.5	0.9
Migraine (self-reported)	2.1	2.6	4.6	-2.1	-1.1	-0.4	-2.1
Medication: Ibuprofen	1.8	2.1	7.0	0.1	-1.0	2.6	-0.7
Medication: Allopurinol	0.9	1.2	3.8	-0.3	-0.5	2.0	-0.8
Medication: Omeprazole	0.2	0.3	0.8	-0.9	-0.5	0.1	0.3
Medication: Seretide 50 evohaler	2.3	2.7	3.8	-2.0	-1.6	-1.9	-1.0
Mean time to correctly identify matches	0.4	0.7	1.8	-0.7	-1.3	-0.3	-0.6
Heart disease (mother)	1.0	1.2	3.3	1.8	-0.1	1.1	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.1	1.7	-1.1	0.8	-1.0	-1.3
Whole body fat mass	0.7	2.9	6.5	0.1	-2.5	-0.8	-2.1
Leg fat mass (right)	0.7	2.7	6.8	0.0	-2.6	-0.1	-2.0
Arm predicted mass (right)	0.8	4.2	7.1	-1.6	-2.6	0.5	-2.7
Pulse rate, automated reading	0.5	1.5	2.5	1.4	0.9	1.6	0.9
Alcohol intake frequency.	0.1	0.2	0.6	0.1	-0.2	-0.8	0.2
Comparative height size at age 10	0.1	0.4	0.7	0.2	-0.7	0.9	-0.3
Number of full sisters	2.7	3.3	8.6	1.3	1.4	-0.9	2.9
Suffer from ‘nerves’	0.4	0.6	1.2	-0.2	-1.0	-1.1	-0.5
Overall health rating	0.8	1.8	3.6	-0.2	-1.8	-0.2	-1.9
Chest pain or discomfort	0.3	0.5	0.9	-0.5	-0.2	-0.9	-0.9
Had major operations	0.5	0.6	1.3	-0.2	0.9	1.1	-0.5
Age at last live birth	0.1	0.1	0.1	-0.3	-0.4	0.1	-0.3
Family relationship satisfaction	0.8	1.0	2.6	-0.1	-1.6	0.2	-1.2
Leg pain on walking	0.9	1.1	2.7	-0.1	-1.0	1.6	-0.9
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	0.7	0.1	-0.3	0.8	-0.8
Commuting to job workplace: Car/motor vehicle	1.0	1.1	3.7	-0.1	-0.0	0.8	1.9
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	2.5	-1.6	-0.4	-0.7	-0.5
Medication: Aspirin	0.6	0.8	2.1	1.1	0.1	-1.5	0.2
Supplements: Vitamin C	2.9	3.4	7.7	-1.2	-2.8	-0.6	-2.1
Knee pain experienced in last month	1.5	2.3	4.6	-2.1	0.2	1.2	-1.8
Hypertension (Self-reported)	0.1	0.2	0.3	0.5	0.5	-0.3	-0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.8	0.5	-0.9	-0.1	0.0
Illnesses of father: Heart disease	0.2	0.2	0.5	-0.7	-0.5	0.3	0.1
Illnesses of siblings: Diabetes	0.2	0.2	0.5	0.3	0.7	-0.6	-0.1
Smoking status: Previous	1.4	2.1	3.5	1.4	0.7	1.5	1.9
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.1	2.6	-1.4	-1.6	-1.6	-1.2
Whole body fat-free mass	0.8	4.6	7.7	-1.8	-2.8	0.7	-2.6
Leg fat-free mass (right)	1.0	5.2	9.2	-1.7	-3.0	-0.5	-3.0
Arm fat percentage (left)	0.5	2.0	3.3	0.9	-1.8	-1.4	-1.5
Average weekly red wine intake	0.2	0.3	0.5	-0.7	-0.7	-0.2	-0.5
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.2	1.0	0.4	1.1	0.4
Mood swings	0.3	0.5	1.0	-0.4	0.5	-0.7	-1.0
Loneliness, isolation	0.4	0.6	1.0	0.0	-1.0	0.9	-0.8
Long-standing illness, disability or infirmity	0.1	0.2	0.3	-0.3	-0.4	0.3	-0.5
Ever had bowel cancer screening	1.3	1.5	2.6	-1.2	-1.6	0.8	-1.1
Diabetes diagnosed by doctor	1.8	2.9	10.6	-0.8	-0.6	-3.3	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	1.1	1.1	-0.9	1.0	0.0
Friendships satisfaction	0.4	0.5	1.3	-0.6	-0.1	-0.6	-1.2
Qualifications: nursing, teaching	3.2	4.9	9.6	2.2	1.6	-1.6	3.1
Commuting to job workplace: Walk	2.3	2.4	4.6	1.2	2.1	-1.6	1.1
Eye problems/disorders: Cataract	0.3	0.3	0.7	0.6	0.8	0.4	-0.0
Mouth/teeth dental problems: Mouth ulcers	2.0	3.2	5.5	-1.5	-2.3	0.2	-2.3
Medication for cholesterol	0.9	1.3	2.9	1.0	-1.7	-1.1	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	2.6	-0.6	1.6	-0.6	1.0
Back pain experienced in last month	0.2	0.3	0.7	0.9	0.6	0.3	0.3
Mineral and other dietary supplements	0.3	0.4	0.8	0.8	-0.1	-0.1	0.9
Breast cancer (self-reported)	0.6	0.7	1.6	-0.7	-1.3	-0.2	-0.9
Asthma (self-reported)	0.7	1.4	3.6	0.3	1.9	0.2	1.4
Osteoporosis (self-reported)	1.3	1.6	3.9	0.4	-1.4	2.0	-0.7
Osteoarthritis (self-reported)	0.6	0.8	1.7	-0.5	1.3	1.1	-0.3
Medication: Aspirin	0.4	0.6	1.7	0.7	-0.3	-1.3	0.1
Medication: Gliclazide	5.3	6.0	18.7	0.6	1.0	-4.3	2.0
Illnesses of father: None of the above (group 1)	1.1	1.4	2.9	-1.7	-0.8	-0.8	-1.1
Smoking status: Current	0.3	0.5	1.2	0.2	0.5	1.1	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.1	6.6	-2.6	-1.2	-0.0	-0.6
Whole body water mass	0.8	4.4	7.1	-1.8	-2.7	0.7	-2.6
Leg predicted mass (right)	0.9	4.9	8.8	-1.6	-3.0	-0.3	-2.8
Arm fat mass (left)	0.7	3.0	5.4	-0.0	-2.3	-1.3	-2.2
Number of self-reported non-cancer illnesses	0.3	0.4	0.9	0.7	0.9	0.6	-0.1
Average weekly champagne plus white wine intake	0.3	0.4	0.8	-0.7	0.9	-0.5	-0.5
Miserableness	0.3	0.6	1.6	-0.6	0.3	0.4	-1.3
Guilty feelings	1.9	2.9	5.4	-1.8	-1.7	-0.1	-2.3
Wears glasses or contact lenses	1.6	1.8	3.3	1.8	1.4	1.1	0.9
Ever taken oral contraceptive pill	0.6	0.6	1.0	0.5	0.7	-0.8	1.0
Hearing aid user	0.5	0.6	1.5	0.3	1.2	0.9	-0.0
Mother’s age at death	1.5	1.8	2.7	1.3	1.6	1.4	1.0
Financial situation satisfaction	0.2	0.2	0.8	-0.1	0.2	0.9	-0.4
Tinnitus: Yes, now most or all of the time	0.8	0.9	2.5	0.0	1.1	0.0	1.6
Commuting to job workplace: Public transport	1.4	1.7	4.1	1.3	0.2	-2.0	-0.9
Eye problems/disorders: Glaucoma	0.1	0.2	0.3	-0.2	0.4	-0.5	0.5
Medication: Blood pressure	0.5	1.0	2.7	0.6	1.6	0.9	0.4
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.5	0.3	-0.3	-0.4	-0.7
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.6	-0.8	-0.3	0.6	-0.8
High cholesterol (Self-reported)	1.6	2.9	3.4	1.9	1.4	-1.7	1.8
Medication: Bendroflumethiazide	0.8	1.2	2.3	-1.5	0.2	0.9	-1.4
Medication: Paracetamol	0.7	1.1	4.3	0.2	0.2	2.1	0.4
Medication: Lisinopril	0.1	0.1	0.4	-0.0	0.3	0.6	0.0
Medication: Atorvastatin	0.8	1.0	2.4	1.5	1.1	-0.3	0.6
Illnesses of father: High blood pressure	1.1	1.4	3.4	1.9	0.7	0.2	1.3
Alcohol drinker status: Never	1.1	1.3	3.8	-1.9	0.1	-0.1	1.2
Ever smoked	1.2	2.1	4.1	0.8	1.0	1.6	2.0
Basal metabolic rate	0.9	5.1	8.9	-1.7	-3.0	0.5	-2.9
Leg fat percentage (left)	0.3	1.1	1.5	1.1	-1.2	-0.3	-1.2
Arm fat-free mass (left)	1.0	5.1	8.7	-2.0	-2.7	0.5	-3.0
Number of operations (self-reported)	1.6	2.4	8.1	-0.3	0.9	2.8	0.7
Average weekly beer plus cider intake	0.4	0.6	1.1	0.5	-0.7	0.7	-1.0
Irritability	0.8	1.3	2.0	1.4	1.3	-1.3	0.1
Risk taking	0.3	0.5	1.1	-0.6	0.1	-0.7	1.0
Ever had prostate specific antigen (PSA) test	0.5	0.5	2.0	-1.4	0.3	-0.0	-0.3
Fractured/broken bones in last 5 years	0.1	0.1	0.4	-0.1	-0.3	-0.0	-0.6
Age started oral contraceptive pill	1.7	2.2	5.1	-1.2	-0.2	-1.5	-2.3
Diastolic blood pressure, automated reading	0.3	1.1	2.3	1.5	1.2	0.7	0.1
Ever depressed for a whole week	0.1	0.1	0.4	0.1	0.1	0.7	-0.2
Unable to work because of sickness or disability	0.2	0.3	0.6	-0.8	-0.2	-0.2	-0.5
Commuting to job workplace: Cycle	0.5	0.6	1.6	-0.2	0.5	-0.7	-1.3
Myopia	1.2	1.8	2.7	-1.3	-1.0	-1.6	-1.4
Vascular/heart problems diagnosed by doctor	0.1	0.4	1.3	-1.1	-0.6	-0.1	-0.0
Cholesterol lowering medication	0.4	0.5	1.7	0.4	1.3	0.1	0.5
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.4	0.0	0.1	-0.6	0.4
Pain experienced in last month	0.1	0.2	0.2	0.5	-0.4	-0.3	0.5
Supplements: Calcium	0.3	0.3	0.7	0.3	0.1	-0.9	-0.7
Basal cell carcinoma (self-reported)	1.7	2.0	3.5	-1.9	-1.4	1.2	-1.1
Heart attack/myocardial infarction (self-reported)	0.9	1.1	3.0	0.9	1.7	0.5	0.5
Deep venous thrombosis (DVT) (self-reported)	1.6	2.1	3.3	-1.0	-1.4	-1.4	-1.8
Heart disease (siblings)	0.7	0.8	1.4	0.9	0.1	1.0	-1.2
Alcohol drinker status: Previous	1.8	2.0	2.5	-1.1	-1.6	-1.5	-1.5
Pack years of smoking	2.0	2.9	5.0	-1.3	-1.9	-1.1	-2.2
Impedance of whole body	0.0	0.1	0.2	0.3	-0.0	-0.4	0.2
Leg fat mass (left)	0.6	2.3	5.0	0.1	-2.2	-0.5	-2.0
Arm predicted mass (left)	0.8	4.0	6.9	-1.8	-2.4	0.6	-2.6