Hub : Genes

RP11-352G18.2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.1059	0.0420	5.9e-03	0.021	NA	0.000	NA	0.003	8.3e-03	NA	3.2e-01	NA	1.6e-01
2	GTEx	Brain Cerebellum	0.4400	0.1180	3.4e-03	0.161	NA	0.155	NA	0.255	1.7e-05	NA	2.5e-05	NA	3.8e-08
3	GTEx	Breast Mammary Tissue	0.2000	0.0630	3.7e-04	0.056	NA	0.096	NA	0.085	7.4e-04	NA	1.3e-05	NA	3.7e-05
4	GTEx	Breast Mammary Tissue (Male)	0.1133	0.0861	1.2e-01	0.004	NA	-0.012	NA	-0.007	2.5e-01	NA	8.4e-01	NA	5.1e-01
5	GTEx	Breast Mammary Tissue (Female)	0.2488	0.0966	1.2e-02	0.050	NA	0.011	NA	0.046	1.3e-02	NA	1.4e-01	NA	1.7e-02
6	GTEx	Cells EBV-transformed lymphocytes	0.4580	0.1260	8.4e-03	0.213	NA	0.084	NA	0.131	1.5e-07	NA	1.0e-03	NA	4.9e-05
7	GTEx	Cells Transformed fibroblasts	0.2810	0.0640	4.8e-06	0.133	NA	0.130	NA	0.151	3.7e-10	NA	5.7e-10	NA	2.0e-11
8	GTEx	Lung	0.0843	0.0362	8.8e-03	0.010	NA	0.018	NA	0.020	5.4e-02	NA	1.5e-02	NA	1.1e-02
9	GTEx	Muscle Skeletal	0.1231	0.0313	8.7e-07	0.020	NA	0.113	NA	0.101	4.3e-03	NA	3.6e-11	NA	4.0e-10
10	GTEx	Spleen	0.3590	0.1100	2.5e-03	0.175	NA	0.037	NA	0.076	2.9e-05	NA	4.0e-02	NA	5.3e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	1.0	1.6	4.9	-1.3	-0.7	-1.5	-0.8	-1.0	-1.4	-1.7	-0.6	-2.2	0.0
Bipolar Disorder or Schizophrenia	0.2	0.6	2.1	-0.9	-0.9	-0.5	-0.7	-0.3	-1.5	-0.9	0.3	-0.4	0.0
Depressed Affect (Nagel 2018)	0.3	0.6	1.8	-0.5	-0.5	-1.3	1.0	-0.5	-0.3	-0.6	-0.7	-1.1	-0.2
Depression (Nagel 2018)	0.6	0.9	2.4	-1.1	-1.5	-0.7	-1.1	-1.1	-0.4	-1.1	-1.0	-0.4	0.2
Intelligence (Savage-Jansen 2018)	1.2	3.6	11.5	0.2	-0.1	2.9	-1.2	3.4	0.1	0.0	3.4	1.9	-0.3
Neuroticism (Nagel 2018)	0.1	0.3	2.2	-0.5	-0.3	0.2	0.3	0.4	-0.1	-0.1	0.1	0.4	1.5
Schizophrenia (2018)	0.2	0.4	1.5	-0.2	-0.5	0.6	-0.4	0.4	-0.7	0.3	0.9	1.2	0.0
Schizophrenia vs Biploar Disorder	0.4	0.5	2.7	-0.4	-0.1	0.9	-0.6	0.1	-1.1	0.2	0.3	1.6	0.0
Worry (Nagel 2018)	0.7	1.4	4.5	-1.2	-0.8	1.8	0.0	1.2	-0.9	-0.5	0.8	1.0	2.1
Alzheimer’s Disease (in mother)	2.8	3.2	7.3	-2.7	-2.7	-0.7	-2.1	-1.1	-2.4	-1.8	-0.8	-0.7	1.4
Alzheimer’s Disease (in father)	0.4	0.4	2.6	-0.5	-0.2	-0.5	0.2	-0.2	-0.6	-0.3	-0.6	1.6	0.6
Alzheimer’s Disease (including proxy)	1.5	2.2	4.7	-2.1	-2.1	-0.8	-1.4	-1.1	-2.2	-1.4	-0.9	0.3	1.2
Crohns Disease (2017)	0.5	1.1	3.5	-1.9	-1.3	0.1	0.2	-0.1	-1.6	-1.5	-0.4	-0.0	0.5
Irritable Bowel Disease (IBD)	0.3	0.7	2.2	-0.8	-0.1	-1.0	-0.7	-1.0	-0.5	-0.7	-0.8	-1.5	-0.1
Ulcerative Colitis (UC)	0.5	1.0	3.2	0.2	0.7	-1.3	-1.0	-1.2	0.2	-0.1	-0.9	-1.8	-0.8
Major Depression (MDD)	0.8	1.0	3.2	0.5	0.0	-1.5	-1.8	-1.4	0.5	0.9	-1.0	0.3	0.0
Reaction Time	0.1	0.3	1.1	0.6	0.5	0.3	-0.5	-0.4	0.1	0.3	-0.1	-1.1	-0.3
Verbal and Numeric Reasoning (VNR)	0.4	1.0	3.2	0.2	0.7	1.4	-1.3	1.5	0.0	0.0	1.8	0.6	0.0
Breast Cancer	0.7	1.7	4.5	-0.9	-1.5	1.2	0.8	1.6	-0.3	-1.3	1.5	0.7	-2.1
Ovarian Cancer	0.3	0.4	1.0	-0.2	-0.5	-0.7	-0.6	-0.7	1.0	-0.2	-0.9	-0.6	-0.2
Prostate Cancer	3.4	4.8	21.8	1.9	2.1	0.9	0.1	0.2	2.0	3.2	0.7	1.7	4.7
Age at First Birth	0.2	0.3	0.9	-0.2	0.6	0.7	-0.6	0.9	0.0	-0.6	0.7	0.4	0.0
Bipolar Disorder (2011)	1.3	1.3	3.3	-0.5	0.0	-1.6	-0.5	-1.8	0.0	-0.8	-1.7	-1.6	0.0
Body Mass Index (BMI) (2010)	1.5	2.1	5.6	-0.7	-0.1	-1.8	-1.2	-2.2	-0.3	-1.1	-2.4	-2.0	0.0
Coronary Artery Disease (CAD)	1.4	1.7	5.1	-1.5	-1.5	-0.8	-1.1	-0.3	-2.2	-1.9	-0.1	-1.4	0.0
Crohns Disease (2012)	0.2	0.4	1.1	0.6	0.8	0.3	0.5	-0.3	1.0	1.0	-0.4	0.6	0.0
Mean Putamen Volume	0.4	0.5	1.6	-0.1	0.1	-1.3	-0.8	-1.0	-0.1	0.5	-0.8	-0.9	0.0
Fasting Glucose	0.1	0.1	0.6	-0.3	-0.0	-0.4	-0.8	0.1	-0.1	-0.1	-0.4	-0.2	0.2
HbA1C	0.9	1.0	3.6	-1.8	-1.4	-0.1	0.1	0.2	-1.9	-0.8	0.5	0.5	0.0
HDL Cholesterol	0.4	0.7	1.9	-0.0	-0.8	1.1	0.5	1.4	0.1	-0.2	1.0	1.3	0.0
LDL Cholesterol	0.3	0.5	1.4	1.2	0.9	-0.4	-0.6	0.2	0.9	1.0	0.2	-0.4	0.0
Lupus	0.1	0.2	0.6	0.1	0.3	-0.8	-0.1	-0.5	0.4	0.0	-0.3	-0.6	0.0
Neuroticism (2016)	0.2	0.3	0.8	-0.0	0.9	-0.7	-0.5	-0.7	0.3	-0.0	-0.6	-0.6	0.5
Primary Biliary Cirrhosis	0.4	0.6	1.6	0.9	1.1	0.5	-0.6	0.6	0.1	1.3	0.9	0.4	0.0
Rheumatoid Arthritis	0.6	0.9	3.1	-0.1	-0.2	-1.4	-0.4	-1.8	0.0	0.0	-1.7	-0.6	0.0
Schizophrenia (2014)	0.4	0.8	2.8	0.1	-0.0	1.5	-0.4	0.9	-0.6	0.5	1.3	1.7	0.0
Triglycerides	0.8	1.3	4.7	1.6	1.6	0.1	-1.0	-0.3	1.1	2.2	-0.1	1.1	0.0
Type 2 Diabetes (T2D) (2012)	0.5	0.6	2.6	0.2	0.7	-0.4	0.6	-1.6	0.2	0.5	-1.3	-0.2	0.0
Ulcerative Colitis	1.1	1.6	3.6	1.1	1.9	-1.7	-0.6	-1.6	1.0	1.1	-1.2	-1.2	0.0
Blood Eosinophil Count	0.2	1.4	3.6	-1.1	-0.0	-1.5	1.7	-1.9	-0.1	-0.6	-1.6	-0.7	0.8
Blood Platelet Count	0.1	0.9	2.5	-1.6	-0.7	0.4	-1.2	-0.1	-1.1	-1.4	0.1	1.2	0.5
Blood Red Count	0.1	1.0	6.1	0.6	1.5	0.6	2.5	0.8	-0.0	0.3	0.6	-0.2	0.3
Blood White Count	0.1	0.7	4.5	0.0	0.1	-0.2	1.1	-0.0	0.4	-0.9	-0.4	-0.2	-2.1
Heel T-Score	0.1	0.7	1.8	-0.2	1.2	0.1	0.4	1.3	-0.5	-0.2	1.3	-0.9	-0.7
BMI	0.8	4.7	10.8	-2.1	-1.2	-3.3	-1.7	-3.2	-2.1	-2.0	-2.6	-1.0	-1.1
Height	0.5	9.1	33.9	1.4	1.3	4.2	0.5	2.8	0.8	2.2	2.1	5.8	4.1
Waist Hip Ratio (WHR)	0.5	2.2	7.3	0.4	1.2	-2.0	0.7	-1.4	0.7	-0.9	-1.8	-1.5	-2.7
Systolic Blood Pressure	0.1	0.3	1.6	0.0	-0.2	-0.6	-0.2	0.4	-0.3	-1.0	0.3	-0.1	-1.3
Smoking Status	0.5	1.2	3.1	-0.1	1.2	-1.8	-0.4	-1.4	-0.3	0.6	-0.6	-1.6	1.6
Allergy or Eczema	0.8	2.0	10.0	-0.8	-0.6	1.6	-0.7	1.2	-0.1	0.3	1.0	1.9	3.2
Cardiovascular Disease	0.3	0.8	2.5	0.5	1.2	-0.8	-1.6	-0.7	0.4	-0.6	-0.4	-0.5	-1.5
Hypothyroidism (self reported)	0.8	1.8	5.9	0.8	1.3	-1.5	-1.5	-1.9	0.6	0.3	-2.4	-0.7	-0.8
Respiratory disease	0.5	1.1	4.2	-0.7	-0.4	-1.0	-0.7	-2.1	-0.0	-0.4	-1.7	-0.2	1.0
Type 2 Diabetes (T2D) (2018)	0.6	1.1	2.0	-1.2	-0.8	-1.4	0.1	-1.4	-1.0	-1.2	-1.4	-0.9	-0.4
Lung FEV1/FVC ratio	0.1	0.6	1.6	1.1	1.3	0.5	-0.6	0.3	0.3	0.6	0.1	0.6	-1.2
Lung FVC	0.3	1.4	5.3	0.5	1.2	-0.1	-2.3	-0.0	0.2	1.2	0.4	-1.7	1.6
Neuroticism	0.4	1.0	2.6	-1.6	-1.1	0.3	1.0	0.1	-1.3	-1.2	0.1	-0.4	1.2
Chronotype (morning person)	0.8	1.8	7.3	-1.3	-1.4	-0.7	-1.4	-1.2	-0.9	-1.4	-0.7	-2.7	-0.6
Hair Pigment	0.1	2.8	8.1	-2.7	-1.8	-1.4	-0.9	-1.1	-1.5	-2.9	-1.2	-0.5	-1.1
Tanning	0.0	0.5	4.2	-0.3	-0.5	0.0	0.1	-0.3	-0.4	-0.5	0.0	-2.0	-0.6
Hand grip strength (left)	1.0	2.6	13.3	0.2	0.1	0.3	-2.2	-0.6	-0.7	1.4	-1.1	1.9	3.7
Number of treatments/medications taken	2.1	3.8	9.5	0.1	1.3	-2.3	-2.0	-3.1	0.3	-0.5	-2.5	-3.0	-1.4
Average weekly spirits intake	1.2	1.4	4.0	1.3	1.3	-1.0	-2.0	-1.0	1.0	1.1	-0.2	-1.7	0.1
Sensitivity / hurt feelings	1.4	2.4	8.2	1.1	1.0	1.2	-1.6	0.7	1.2	2.1	1.1	1.5	2.9
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.6	-0.0	-0.3	-0.5	0.8	-0.4	0.1	-0.1	-0.5	-0.6	-0.4
Hearing difficulty/problems: Yes	0.4	0.7	2.1	0.0	-0.6	-1.2	-0.3	-0.4	-0.3	-0.4	-0.6	-1.4	-1.3
Relative age of first facial hair	0.5	1.0	3.2	0.6	0.1	1.8	-0.1	1.2	-0.1	0.8	1.0	1.6	0.9
Other serious medical condition/disability diagnosed by doctor	1.0	1.4	3.5	1.2	1.9	-0.3	-1.9	-0.8	1.2	0.8	-0.9	-0.7	-0.9
Ever used hormone-replacement therapy (HRT)	0.3	0.4	2.2	0.1	0.4	-1.5	0.8	0.2	-0.0	-0.0	-0.0	-0.4	-0.6
Ever had hysterectomy (womb removed)	1.8	2.0	6.3	-1.0	-0.4	-1.8	0.4	-1.9	-1.1	-1.1	-1.8	-2.5	-0.4
Systolic blood pressure, automated reading	0.2	0.5	1.3	-0.6	-1.0	-0.0	0.1	0.8	-0.9	-1.1	0.4	0.8	-0.5
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	2.3	-0.5	0.2	-0.4	-1.5	0.3	-0.1	-0.2	0.2	0.7	0.6
Angina	1.4	1.8	5.1	0.6	1.1	-2.2	-0.5	-2.1	0.5	0.5	-1.8	-1.7	-0.2
Medication for hormone replacement therapy	1.7	1.9	4.1	1.8	1.5	0.7	-0.2	2.0	1.8	1.5	1.6	0.7	-0.6
Vitamin and mineral supplements	0.5	0.7	1.6	-1.0	-1.2	0.9	0.6	0.4	-0.4	-1.3	-0.3	0.3	-1.2
Supplements: Zinc	2.0	2.1	4.9	0.6	1.4	-2.2	-0.8	-2.0	0.8	1.1	-2.1	-0.6	1.8
Medication: Co-codamol	0.4	0.4	2.3	0.3	-0.0	-0.4	-1.1	-0.3	0.0	0.7	-0.4	0.1	1.5
Medication: Metformin	0.4	0.5	2.1	-0.5	0.3	-1.5	0.7	-0.9	-0.6	-0.5	-0.7	0.0	-0.4
Diabetes (father)	0.6	0.7	1.5	0.1	0.3	-1.2	0.9	-1.1	0.2	-0.4	-1.0	-0.8	-1.2
Diabetes (mother)	1.0	1.3	2.9	-0.5	0.6	-1.2	1.7	-1.7	-1.4	-0.4	-1.2	-1.1	0.6
Severe depression (siblings)	3.2	3.6	11.4	-0.1	0.3	-2.9	-0.2	-3.4	-0.7	-0.4	-3.4	-1.9	-0.7
Pack years adult smoking proportion	2.0	3.1	7.2	-0.7	-1.3	-2.7	-0.2	-2.1	-0.5	-1.4	-2.0	-2.3	-2.4
Impedance of leg (right)	0.4	1.9	4.0	2.0	0.9	1.6	1.1	1.5	1.9	0.9	1.1	-0.2	-1.5
Leg fat-free mass (left)	0.5	2.5	5.4	-2.0	-0.9	-0.7	-1.2	-1.4	-2.3	-0.9	-1.2	1.9	2.3
Trunk fat percentage	0.9	3.6	8.8	-2.6	-2.0	-1.4	-0.7	-1.5	-2.4	-3.0	-1.7	0.2	-1.8
Hand grip strength (right)	0.7	1.9	7.4	-0.5	-0.7	0.5	-2.7	-0.2	-1.2	0.4	-0.7	2.0	2.2
Townsend deprivation index at recruitment	0.4	0.5	1.3	0.2	0.8	-0.8	-0.1	-0.9	0.4	0.6	-1.1	0.3	1.1
Current tobacco smoking	0.5	0.8	2.3	-1.1	0.1	-1.5	0.1	-0.6	-1.3	-0.7	-0.3	-1.2	0.7
Average weekly fortified wine intake	0.6	0.7	2.4	0.3	0.2	1.5	-0.7	1.2	0.4	0.5	1.0	0.9	1.0
Maternal smoking around birth	1.1	1.7	3.6	0.9	0.4	-1.8	-0.9	-1.7	1.3	0.7	-1.9	-1.6	-0.5
Fed-up feelings	0.1	0.3	1.3	0.5	-0.1	-0.8	0.2	-0.3	0.1	0.4	-0.2	-1.1	-0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.5	2.1	4.1	-1.4	-1.4	-1.8	-0.0	-2.0	-0.9	-1.3	-1.9	-1.7	0.3
Relative age voice broke	1.9	2.8	8.7	0.9	0.3	3.0	1.2	2.5	-0.0	0.9	2.2	2.1	0.9
Taking other prescription medications	3.2	4.9	15.8	-0.1	1.4	-3.2	-1.7	-4.0	0.2	-0.3	-3.7	-2.0	-0.2
Age when periods started (menarche)	2.5	5.9	9.9	3.2	2.7	3.2	-0.1	2.6	2.8	2.6	2.2	2.4	0.1
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	3.9	0.5	1.5	-2.0	-0.2	-1.2	-0.1	0.7	-1.3	-1.0	0.9
Heel bone mineral density (BMD) T-score, automated (left)	1.6	3.5	9.4	-3.1	-3.0	-0.7	-0.7	0.3	-2.2	-2.8	0.4	-1.4	-0.7
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	3.4	0.7	-0.3	-0.8	1.8	-0.7	1.2	1.3	-1.0	0.1	1.6
Qualifications: CSEs or equivalent	3.6	4.7	10.1	-1.5	-1.9	-2.4	1.5	-3.2	-1.1	-1.9	-2.9	-2.8	-1.6
Serious illness, injury or assault to yourself	1.3	1.6	4.1	0.8	0.9	-0.8	-1.4	-1.6	0.8	1.2	-1.7	0.6	2.0
High blood pressure	0.3	0.8	2.9	-0.2	0.3	-1.3	-1.4	-0.3	-0.3	-1.2	-0.3	-0.4	-1.7
Hayfever, allergic rhinitis or eczema	0.4	0.9	3.4	-0.2	-0.1	1.3	-0.4	0.9	0.2	0.4	0.8	1.3	1.8
Multivitamins +/- minerals	0.3	0.4	1.2	0.5	0.5	-0.8	0.7	-0.4	0.3	0.9	0.3	-0.0	1.1
Stomach or abdominal pain in last month	1.1	1.4	3.5	-0.6	0.1	-1.6	-0.5	-1.5	-0.8	-0.0	-1.9	0.8	1.8
Supplements: Glucosamine	0.2	0.3	0.6	0.3	0.5	-0.5	0.6	-0.2	0.3	0.6	0.1	-0.8	0.8
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.6	-0.1	0.2	-1.1	0.2	-1.0	-1.0	-0.1	-1.3	-1.1	-0.5
Medication: Atenolol	1.2	1.5	8.9	-0.9	-0.6	-1.0	-3.0	0.2	0.1	-1.3	0.1	-0.1	-1.5
Medication: Levothyroxine sodium	0.4	0.7	3.9	0.5	0.7	-0.3	0.2	-1.3	0.9	0.2	-2.0	0.2	0.3
Sitting height	0.4	3.0	15.7	0.2	0.3	1.4	-0.9	-0.4	-0.4	1.4	-0.3	2.9	4.0
Chronic bronchitis/emphysema (father)	2.3	2.7	7.0	-2.6	-2.3	-0.6	0.0	-1.5	-1.8	-1.5	-1.5	-0.0	2.1
High blood pressure (mother)	1.1	1.5	3.7	-0.3	-0.4	1.9	-1.1	1.6	-0.3	-0.9	1.9	1.2	-1.1
Body mass index (BMI)	1.5	6.3	10.4	-3.2	-2.1	-3.1	-1.5	-3.1	-3.0	-3.0	-2.6	-1.0	-0.8
Impedance of leg (left)	0.6	2.8	6.0	2.5	1.4	1.9	0.5	2.0	2.3	1.3	1.6	0.1	-1.6
Leg predicted mass (left)	0.5	2.6	5.6	-2.1	-0.9	-0.6	-1.3	-1.3	-2.4	-0.9	-1.1	1.9	2.4
Trunk fat mass	1.0	4.3	8.9	-2.9	-2.0	-1.5	-1.4	-1.9	-2.9	-3.0	-1.9	0.5	-1.1
Waist circumference	1.1	4.1	6.7	-2.4	-1.0	-2.4	-2.0	-2.6	-2.3	-2.5	-2.4	-0.5	-1.0
Number of incorrect matches in round	0.9	1.6	5.1	-0.8	-0.9	1.4	0.0	1.4	-0.1	0.1	1.6	1.6	2.3
Past tobacco smoking	1.7	3.0	9.9	-1.9	-3.1	1.8	0.5	1.8	-0.8	-2.2	1.5	0.3	-1.6
Alcohol usually taken with meals	0.3	0.5	3.5	-0.4	-0.5	-0.6	-1.9	-0.1	-0.6	0.0	-0.2	-0.4	0.7
Nervous feelings	0.3	0.5	2.1	0.3	0.1	1.1	-0.4	0.6	-0.4	0.7	0.1	0.9	1.5
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	2.1	-0.4	-0.6	-0.8	-1.4	-0.8	-0.5	-0.1	-0.9	-0.5	1.4
Hearing difficulty/problems with background noise	0.4	0.7	1.3	-0.8	-0.8	-0.6	1.1	-0.0	-0.9	-1.1	-0.7	-0.8	-1.0
Hair/balding pattern: Pattern 2	0.7	0.9	3.4	0.3	-0.6	1.9	0.6	1.2	-0.8	0.3	1.3	0.7	0.5
Had menopause	1.1	1.4	5.3	-0.1	0.8	-2.3	0.1	-1.3	-0.1	-0.6	-1.5	-1.2	-1.6
Had other major operations	1.2	1.4	7.1	1.5	2.7	-0.3	-0.6	-0.2	1.7	1.1	-0.5	0.3	-0.4
Forced vital capacity (FVC)	0.9	3.6	8.4	2.2	2.8	0.7	-2.0	0.2	1.4	2.9	0.2	1.5	2.4
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.9	5.6	-2.4	-1.5	-0.7	-0.8	0.7	-2.0	-2.2	0.6	-0.7	-0.5
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	2.4	1.5	1.3	-1.2	-1.1	-0.5	1.4	1.4	-0.9	-0.3	-0.2
Qualifications: None of the above	0.6	1.2	2.5	-1.0	-1.5	-1.4	1.2	-0.8	-0.9	-0.9	-0.8	-1.6	-0.3
Financial difficulties in last 2 years	2.1	2.9	5.5	-2.3	-2.0	-1.7	0.4	-1.7	-2.1	-2.3	-1.5	-1.1	-0.4
Mouth/teeth dental problems	0.1	0.2	0.6	-0.4	-0.2	0.3	0.7	-0.0	-0.3	-0.5	0.3	-0.5	-0.7
Heart attack	1.0	1.3	2.7	0.6	1.3	-1.3	-0.9	-1.6	0.7	0.2	-1.4	-1.4	-1.0
Allergy	0.3	0.8	3.1	-0.0	0.1	-1.5	-0.5	-0.6	-0.5	-0.6	-0.6	-1.0	-1.8
Pain all over the body in last month	0.1	0.1	0.6	-0.1	0.2	0.4	0.1	0.2	0.0	-0.2	0.4	-0.8	-0.6
Diabetes (self-reported)	1.1	1.7	5.1	-0.5	-0.1	-2.3	-0.2	-1.9	0.1	-0.8	-2.0	-1.5	-1.2
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	1.0	0.2	-0.4	0.7	1.0	0.3	0.3	0.1	0.6	-0.5	-0.4
Medication: Ramipril	3.2	4.1	7.3	2.3	1.4	-2.5	0.2	-2.7	2.5	2.2	-2.4	-1.4	1.0
Medication: Simvastatin	0.5	0.8	4.7	0.4	0.2	-0.9	-2.2	-0.4	-0.3	-0.2	-0.3	-0.5	-1.3
Fluid intelligence score	0.4	0.9	3.9	0.4	-0.0	1.6	-0.5	1.5	0.1	0.1	2.0	-0.0	-0.1
Illnesses of siblings	0.3	0.5	2.6	0.5	0.2	-0.1	-0.2	-0.5	0.4	1.0	-0.7	0.3	1.6
Neuroticism score	0.3	0.6	3.3	-0.9	-0.2	0.3	0.1	0.0	-1.1	-0.3	0.1	-0.2	1.8
Weight	0.8	3.9	8.1	-2.6	-1.5	-1.5	-2.1	-2.3	-2.8	-1.9	-2.1	1.0	0.9
Impedance of arm (right)	0.8	3.8	9.7	2.1	0.6	3.1	1.6	2.8	2.0	1.1	2.1	0.9	-1.6
Arm fat percentage (right)	1.3	5.0	11.0	-2.9	-2.3	-1.8	-1.3	-2.1	-2.6	-3.3	-1.8	-0.8	-2.1
Trunk fat-free mass	0.5	3.0	12.5	-1.5	-0.1	-0.1	-2.1	-1.1	-2.0	-0.0	-0.6	2.2	3.5
Hip circumference	0.5	2.0	4.2	-2.0	-1.4	-0.4	-2.0	-1.1	-2.0	-1.4	-0.7	1.1	0.6
Time employed in main current job	1.2	1.4	3.6	0.7	1.9	-1.2	-0.2	-1.4	1.1	0.3	-1.6	-1.4	-0.7
Alcohol intake versus 10 years previously	0.2	0.2	0.7	-0.3	-0.2	-0.7	-0.0	-0.9	-0.4	-0.4	-0.5	-0.3	-0.6
Father’s age at death	0.6	0.8	2.2	-1.4	-1.1	-0.1	0.9	-0.0	-0.9	-1.5	-0.0	0.0	-0.8
Worrier / anxious feelings	0.7	1.3	3.9	-1.7	-1.1	1.0	0.9	0.3	-1.5	-0.9	0.6	0.3	2.0
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.4	3.5	1.1	0.8	-1.4	-0.6	-1.6	0.6	1.4	-1.9	0.2	1.2
Falls in the last year	0.7	1.0	1.8	-1.2	-1.0	-1.3	-0.9	-1.0	-0.9	-0.9	-0.6	-1.4	0.2
Hair/balding pattern: Pattern 3	1.5	2.3	6.8	2.4	2.2	-0.4	0.3	-0.5	2.6	2.0	-0.3	-0.9	-0.1
Number of live births	0.6	0.9	3.2	-0.4	-0.6	-1.1	0.6	-0.7	-0.5	-0.7	-0.8	-1.8	-1.3
Forced expiratory volume in 1-second (FEV1)	1.1	3.7	8.3	2.5	2.7	1.0	-2.4	0.3	1.3	2.9	0.3	1.6	1.9
Pulse rate	0.6	1.1	2.3	1.4	1.4	-0.2	-1.0	-0.1	0.8	1.5	-0.2	1.2	1.1
Happiness	0.8	1.0	2.6	1.5	1.4	0.1	0.8	-0.6	0.4	1.6	-0.9	0.5	0.9
Noisy workplace	1.3	1.6	4.1	-0.6	0.5	-1.9	1.4	-0.9	-0.3	-1.1	-0.8	-1.8	-2.0
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.8	0.5	-0.0	0.9	-0.8	0.3	-0.3	0.2	0.4	0.6	-0.0
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	2.7	-0.4	-0.5	-1.4	-0.6	-1.1	-0.5	0.3	-1.1	0.0	1.6
Mouth/teeth dental problems: Dentures	0.6	1.0	3.2	-1.0	-1.8	-0.1	-0.7	0.9	-1.6	-0.5	0.6	0.7	0.7
Asthma	0.3	0.7	1.6	-1.0	-0.5	-0.6	0.7	-1.2	-0.4	-0.6	-1.2	0.0	0.9
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	3.2	-1.6	-1.0	-0.3	-0.5	-1.0	-1.3	-1.1	-0.6	-0.1	1.8
Medication: Cholesterol lowering	1.0	1.5	4.8	-0.6	-0.1	-1.0	-2.2	-1.6	-0.7	-0.9	-1.6	-1.3	-1.0
Depression (self-reported)	0.4	0.5	2.1	-0.2	0.6	0.2	-1.2	-0.6	-0.1	-0.6	0.2	-0.6	-1.5
Medication: Lansoprazole	0.3	0.4	1.9	-0.2	-0.0	-0.6	0.1	-0.4	0.4	-0.4	0.0	-1.4	-0.9
Prospective memory result	0.7	0.8	4.4	-0.0	-0.6	0.1	2.1	-0.8	0.5	-0.2	-1.3	-0.8	-0.4
Lung cancer (father)	0.2	0.3	2.0	-0.1	0.3	0.4	-0.4	-0.2	-0.3	-0.3	-0.1	-1.4	-0.4
Illnesses of mother	1.1	1.3	3.6	1.3	1.1	0.8	0.1	0.1	1.5	1.9	-0.2	0.9	1.8
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.2	6.9	2.6	2.5	1.4	-2.1	0.6	1.6	2.6	0.4	1.3	1.1
Pulse wave Arterial Stiffness index	0.2	0.3	0.9	0.0	0.6	0.1	-0.2	0.9	-0.2	-0.3	0.6	-0.6	-0.9
Impedance of arm (left)	0.7	3.3	9.6	1.7	0.2	3.1	1.7	2.8	1.6	0.8	1.8	1.2	-1.3
Arm fat mass (right)	1.1	4.6	9.7	-3.1	-2.0	-1.7	-1.9	-2.1	-3.0	-2.9	-1.8	0.1	-0.6
Trunk predicted mass	0.5	2.9	12.0	-1.5	-0.1	-0.1	-2.0	-1.1	-2.0	-0.1	-0.6	2.2	3.5
Standing height	0.7	7.0	22.5	1.1	1.3	3.6	-1.7	1.8	0.1	2.2	1.3	4.7	4.4
Length of working week for main job	0.3	0.3	0.9	-0.9	-0.2	-0.1	0.7	0.0	-0.7	-1.0	0.1	-0.2	-0.5
Exposure to tobacco smoke at home	0.5	0.6	1.6	1.0	0.4	-0.7	0.5	-0.2	1.2	0.4	0.2	-1.0	-1.3
Breastfed as a baby	1.4	1.8	4.3	1.6	1.5	0.8	-0.6	0.7	2.1	1.9	0.5	1.4	0.9
Tense / ‘highly strung’	0.4	0.6	3.5	0.0	0.4	0.7	-1.1	-0.4	-0.1	0.5	0.1	-0.4	1.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	3.6	0.4	1.0	-1.6	-1.9	-1.4	0.3	0.3	-0.6	-1.0	-0.3
Hair/balding pattern: Pattern 4	0.9	2.1	4.6	-1.8	-2.1	-2.1	0.9	-1.5	-1.6	-1.2	-1.4	-0.1	0.4
Birth weight of first child	0.3	0.6	2.1	-0.6	-0.1	1.0	0.4	0.0	-1.1	-0.2	0.7	-1.5	0.4
Peak expiratory flow (PEF)	0.6	1.3	3.6	0.6	1.1	-0.8	-1.0	-1.9	-0.2	1.0	-1.9	0.3	1.3
Pulse wave reflection index	0.5	0.6	1.5	-0.5	-0.5	0.7	-0.3	0.9	-0.9	-0.4	1.2	-1.2	-0.2
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.9	0.3	0.6	-0.7	0.1	-1.0	0.5	0.3	-0.9	-0.9	0.4
Loud music exposure frequency	0.4	0.5	3.1	0.2	0.4	0.6	1.8	0.5	0.2	-0.1	0.4	0.1	-0.8
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	1.4	0.6	0.7	0.3	-0.5	-1.2	0.4	0.5	-0.7	-0.3	0.4
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	1.0	0.2	0.0	-0.6	-0.6	-0.8	0.5	0.1	-1.0	0.0	0.3
Blood clot in the leg (DVT)	0.7	0.9	2.9	-0.6	-1.0	1.7	0.8	1.1	-0.7	-0.7	1.2	0.1	-0.6
Medication: Paracetamol	0.7	1.1	2.1	-1.4	-1.1	-1.0	0.3	-1.2	-1.3	-1.1	-1.2	-1.0	0.3
Headache pain in last month	0.4	0.6	2.4	0.3	-0.1	-0.6	-1.4	-0.4	0.2	-0.3	-0.9	-0.3	-1.6
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	5.1	0.8	0.3	1.0	2.3	1.0	0.7	1.4	0.8	1.8	1.6
Glaucoma (self-reported)	0.3	0.3	1.9	-0.4	0.3	0.1	-0.4	-0.2	-0.7	-0.8	-0.1	-0.2	-1.4
Gout (self-reported)	0.3	0.4	1.3	0.2	0.6	-0.5	-0.8	0.1	-0.8	0.4	-0.3	1.1	0.6
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	4.8	0.8	1.0	-0.8	-0.0	-1.8	0.8	0.6	-2.2	-0.1	0.2
Medication: Amlodipine	2.6	3.6	10.9	-0.4	0.0	-2.4	-0.7	-2.0	-0.6	-1.5	-1.8	-3.3	-3.0
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.1	-0.9	-1.0	-0.2	1.1	-0.3	0.1	-0.8	-0.1	-0.4	-0.1
Birth weight	0.5	1.1	2.4	-1.3	-0.5	-1.1	0.6	-1.5	-1.3	-0.8	-1.3	-1.2	0.2
Chronic bronchitis/emphysema (mother)	1.5	1.8	3.5	-1.5	-1.9	-1.9	0.8	-0.8	-0.6	-1.6	-1.2	-0.9	-1.5
High blood pressure (siblings)	0.3	0.5	1.4	-0.7	-0.0	-0.2	-1.2	0.0	0.1	-1.0	0.5	-0.9	-0.8
Forced vital capacity (FVC), Best measure	0.5	1.9	3.8	1.6	1.7	1.4	-1.7	0.4	0.8	2.0	0.2	1.2	1.7
Body fat percentage	1.3	5.3	12.1	-3.0	-2.2	-2.0	-1.0	-2.0	-2.7	-3.5	-2.1	-0.6	-2.3
Leg fat percentage (right)	2.0	7.4	13.0	-3.0	-2.1	-3.1	-1.1	-3.1	-2.8	-3.6	-2.9	-1.7	-2.7
Arm fat-free mass (right)	0.6	2.9	7.7	-1.8	-0.1	-0.6	-2.1	-1.4	-2.4	-0.6	-1.0	2.1	2.8
Exposure to tobacco smoke outside home	0.6	0.8	4.5	0.3	1.4	-0.3	2.1	-0.6	0.5	0.4	-0.4	-0.7	0.1
Comparative body size at age 10	0.3	0.9	2.2	-1.1	0.3	-1.5	1.5	-0.8	-0.4	-0.8	-1.2	-0.4	-0.3
Number of full brothers	0.4	0.5	2.2	0.2	0.8	-0.7	0.7	-0.7	0.0	-0.2	-0.5	-0.4	-1.5
Worry too long after embarrassment	0.1	0.2	0.7	0.2	0.3	0.2	-0.3	-0.2	0.3	0.4	0.1	0.8	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	9.7	-0.2	-0.4	0.5	-3.1	-0.1	-0.5	-0.2	-0.0	-0.1	0.2
Wheeze or whistling in the chest in last year	1.1	2.0	5.8	-0.8	-0.1	-2.4	0.7	-2.3	-0.8	-0.2	-1.7	-1.5	1.6
Number of children fathered	1.0	1.1	7.5	0.1	0.1	-0.2	-0.2	-0.0	0.1	-0.8	-0.1	-1.7	-2.7
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.1	-1.0	-0.9	0.3	-1.0	0.6	-0.9	-0.5	1.1	0.3	1.0
Age at first live birth	0.5	0.9	3.8	0.6	0.8	1.0	-0.3	1.1	0.3	0.0	0.4	2.0	-1.2
Pulse wave peak to peak time	0.4	0.4	1.5	0.0	-0.5	0.2	0.1	-0.9	0.2	0.4	-0.7	0.9	1.2
Health satisfaction	1.5	1.9	5.6	0.1	0.1	-2.0	-0.5	-2.4	0.2	-0.2	-2.1	-2.0	-0.8
Shortness of breath walking on level ground	1.1	1.3	4.8	0.7	-0.1	-1.0	-2.2	-1.8	0.7	0.7	-1.5	-0.7	-0.0
Qualifications: College or University degree	1.3	4.2	8.2	2.2	1.9	2.4	-1.3	1.8	2.4	2.1	1.9	2.9	0.5
Eye problems/disorders: None of the above	1.7	2.0	5.0	1.1	0.6	2.2	1.7	2.0	0.7	1.0	1.9	1.1	0.5
Mouth/teeth dental problems: Loose teeth	0.3	0.3	1.7	-0.1	-0.1	-0.7	-0.5	-0.8	-0.1	-0.2	-1.3	-0.2	0.2
Emphysema/chronic bronchitis	0.8	0.9	2.8	1.2	1.7	0.6	0.6	-0.2	0.4	1.5	0.1	0.4	1.3
Medication for pain relief, constipation, heartburn	1.3	2.3	4.1	1.6	1.1	1.6	2.0	1.8	1.3	1.6	1.6	1.6	0.5
Neck or shoulder pain in last month	0.9	1.3	5.1	0.5	-0.1	0.4	1.1	0.5	0.2	1.3	0.7	2.0	2.2
Medication: Blood pressure	0.1	0.3	0.7	0.5	0.8	-0.3	-0.4	0.1	0.6	0.1	0.3	-0.6	-0.7
Angina (self-reported)	1.4	1.9	4.8	0.8	1.4	-2.2	-0.8	-1.9	0.7	0.7	-1.7	-1.7	-0.4
Migraine (self-reported)	1.1	1.3	4.7	1.8	1.2	-0.5	0.1	-0.6	2.2	1.6	-0.4	-0.7	-0.1
Medication: Ibuprofen	0.8	1.0	3.2	-1.3	-0.7	-0.6	-0.9	-1.1	-0.6	-0.8	-0.6	-0.7	1.8
Medication: Allopurinol	0.4	0.5	1.7	0.5	0.6	-1.3	-1.1	-0.5	-0.0	0.8	-0.6	0.2	0.4
Medication: Omeprazole	2.4	2.8	8.9	-0.8	-0.6	-1.4	-3.0	-2.4	-0.8	-1.0	-2.8	-0.8	-0.6
Medication: Seretide 50 evohaler	1.2	1.3	3.2	1.4	1.5	0.6	0.6	-0.1	1.8	1.7	0.2	0.4	1.5
Mean time to correctly identify matches	0.1	0.2	0.8	0.3	0.4	-0.1	-0.2	-0.7	0.2	0.1	-0.5	-0.9	-0.4
Heart disease (mother)	2.0	2.4	7.3	-0.8	0.6	-2.0	-0.3	-1.2	-1.6	-1.5	-1.0	-2.7	-2.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	2.8	-0.1	0.6	-1.4	-0.3	-1.3	0.7	-0.2	-1.7	-0.5	-0.3
Whole body fat mass	1.1	4.5	8.8	-2.9	-1.9	-1.9	-1.5	-2.2	-2.9	-3.0	-2.1	0.2	-1.0
Leg fat mass (right)	1.3	5.2	8.4	-2.8	-1.7	-2.5	-1.4	-2.9	-2.7	-2.9	-2.7	-0.4	-1.3
Arm predicted mass (right)	0.6	2.9	6.5	-1.9	-0.3	-0.9	-2.0	-1.6	-2.4	-0.8	-1.3	1.7	2.6
Pulse rate, automated reading	0.1	0.4	1.6	0.7	0.8	-0.1	-1.3	-0.5	0.7	0.5	-0.2	-0.4	0.0
Alcohol intake frequency.	0.5	1.2	2.4	-1.2	-0.1	-1.0	0.9	-1.5	-0.6	-1.3	-1.5	-1.0	-1.2
Comparative height size at age 10	0.5	3.0	7.3	1.4	1.5	-1.0	-1.7	-2.0	1.1	2.1	-2.1	0.4	2.7
Number of full sisters	1.2	1.4	4.3	-2.0	-0.8	-1.5	0.3	-0.3	-2.1	-1.7	-0.3	-0.3	0.1
Suffer from ‘nerves’	0.9	1.4	3.3	-1.0	-0.8	1.8	-1.8	1.4	-0.9	-0.9	1.1	0.7	0.5
Overall health rating	0.7	1.5	4.3	-0.8	-0.6	-1.7	-0.3	-1.9	-0.9	-0.6	-2.1	-1.2	0.5
Chest pain or discomfort	1.9	2.8	8.7	-0.1	0.2	-2.9	-1.0	-2.9	0.5	0.1	-2.6	-1.4	0.7
Had major operations	1.2	1.4	6.1	-0.1	0.6	-1.0	0.7	-2.5	-0.2	0.2	-1.7	-1.7	0.9
Age at last live birth	1.0	1.5	3.8	0.7	0.4	1.7	-1.4	1.9	0.6	0.3	1.6	1.2	-0.9
Family relationship satisfaction	0.2	0.3	1.1	0.4	0.6	-0.3	1.0	0.2	0.1	0.5	0.1	-0.4	0.6
Leg pain on walking	0.4	0.5	1.5	0.8	0.6	-1.0	-0.6	-0.9	0.2	0.5	-1.2	-0.2	-0.8
Qualifications: NVQ or HND or HNC or equivalent	1.7	2.1	7.2	0.6	1.4	-2.3	-0.1	-2.3	0.3	0.4	-2.7	-0.7	-0.0
Commuting to job workplace: Car/motor vehicle	0.7	0.8	2.2	-0.5	-0.8	1.0	1.5	1.2	0.1	-0.3	0.7	1.2	0.3
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	3.5	1.9	1.3	1.2	0.3	1.4	1.3	1.2	1.4	-0.3	-1.6
Medication: Aspirin	1.5	1.9	3.9	-0.5	-0.2	-1.7	-1.7	-2.0	-1.3	-0.9	-2.0	-1.3	-1.1
Supplements: Vitamin C	1.3	1.6	5.2	1.7	2.3	-0.1	-1.7	0.5	1.2	1.5	0.4	0.7	0.5
Knee pain experienced in last month	1.4	2.2	5.8	-0.7	-0.8	-2.1	-0.1	-2.4	-0.5	-0.8	-2.2	-2.1	-0.9
Hypertension (Self-reported)	0.3	0.8	2.0	0.1	0.6	-1.4	-1.4	-0.6	-0.3	-0.8	-0.4	-0.5	-1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	1.2	-0.5	0.3	0.1	-0.8	1.1	-0.2	-0.2	0.9	-0.1	0.2
Illnesses of father: Heart disease	0.6	0.8	2.5	-1.1	0.6	-0.4	-0.6	0.4	-1.6	-1.2	0.7	-0.8	-0.6
Illnesses of siblings: Diabetes	0.6	0.7	2.6	-1.1	0.6	-0.7	1.6	-0.1	-1.4	-0.8	0.1	0.1	0.4
Smoking status: Previous	1.4	2.0	4.6	1.6	2.1	-1.2	-0.7	-1.7	1.2	1.8	-1.5	-0.3	1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	4.7	0.5	0.7	1.6	0.1	1.3	0.2	0.9	0.9	2.2	1.8
Whole body fat-free mass	0.5	2.8	10.0	-1.7	-0.2	-0.4	-1.9	-1.2	-2.1	-0.3	-0.9	2.2	3.2
Leg fat-free mass (right)	0.5	2.4	5.9	-1.9	-0.7	-0.4	-1.5	-1.1	-2.2	-0.7	-0.9	2.0	2.4
Arm fat percentage (left)	1.4	5.4	12.3	-3.2	-2.6	-1.8	-1.2	-1.9	-2.9	-3.5	-1.8	-0.5	-2.0
Average weekly red wine intake	0.8	1.2	5.4	-1.2	-0.8	0.8	-2.3	0.3	-1.2	-1.0	0.3	0.8	0.9
Handedness (chirality/laterality): Left-handed	1.7	2.0	4.0	1.9	2.0	-0.9	1.8	-1.0	1.7	1.8	-1.0	-0.1	0.5
Mood swings	0.4	0.6	2.0	0.6	0.7	-1.4	-0.3	-0.9	0.7	0.6	-1.0	-0.9	0.4
Loneliness, isolation	1.0	1.4	10.4	0.4	0.8	-1.3	3.2	-0.2	0.3	0.3	-0.7	-0.5	-0.8
Long-standing illness, disability or infirmity	0.9	1.4	3.1	0.8	1.4	-1.0	-1.8	-1.3	1.2	0.9	-0.9	-1.6	0.4
Ever had bowel cancer screening	1.5	1.8	4.8	-1.8	-1.5	-0.8	-1.1	-0.8	-2.2	-1.7	-0.8	-1.1	-0.1
Diabetes diagnosed by doctor	0.7	1.1	4.5	-0.8	-0.1	-2.1	0.2	-1.2	-0.6	-0.9	-1.3	-1.1	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	4.6	-0.7	-0.6	0.8	0.2	1.6	-0.6	-0.5	2.1	0.4	0.1
Friendships satisfaction	1.0	1.2	3.3	0.9	0.3	1.8	1.0	0.7	0.8	1.3	0.6	1.2	1.5
Qualifications: nursing, teaching	2.1	3.2	7.3	2.5	2.3	1.5	-0.3	0.9	2.5	2.7	0.8	1.4	1.0
Commuting to job workplace: Walk	0.3	0.3	1.3	-0.6	-0.4	-0.3	-1.1	-0.1	-0.5	-0.2	0.4	-0.7	0.5
Eye problems/disorders: Cataract	0.7	0.9	3.1	-1.0	-0.7	-1.8	-0.2	-1.4	-0.3	-0.5	-0.8	-1.0	0.2
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	3.8	1.2	0.8	0.6	-1.5	0.6	1.9	1.3	0.5	1.4	0.7
Medication for cholesterol	1.5	2.2	4.9	-1.8	-2.0	1.5	1.4	0.7	-1.9	-0.7	1.0	0.7	2.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.4	3.3	-1.3	-0.8	-0.6	1.2	-0.4	-0.7	-1.8	-0.4	-1.6	-1.6
Back pain experienced in last month	0.3	0.4	0.7	-0.8	-0.4	-0.7	0.7	-0.7	-0.8	-0.5	-0.6	-0.1	0.4
Mineral and other dietary supplements	0.3	0.4	2.0	0.1	-0.3	-0.5	-0.6	-0.8	0.3	-0.1	-1.4	0.6	-0.4
Breast cancer (self-reported)	0.3	0.4	0.9	-0.9	0.0	0.9	-0.8	-0.2	-0.8	-0.8	0.1	-0.6	0.4
Asthma (self-reported)	0.5	1.0	2.5	-1.6	-1.0	-0.7	0.4	-1.4	-0.9	-1.1	-1.3	-0.2	1.0
Osteoporosis (self-reported)	0.7	0.9	3.1	0.2	-0.3	1.8	-0.6	1.2	0.3	0.5	1.6	0.4	0.5
Osteoarthritis (self-reported)	1.0	1.3	4.3	-1.8	-1.1	0.5	-0.5	0.2	-1.6	-1.0	0.4	0.0	2.1
Medication: Aspirin	1.1	1.4	3.6	-0.3	-0.1	-1.5	-1.4	-1.9	-1.0	-0.7	-1.9	-0.8	-0.8
Medication: Gliclazide	1.0	1.1	2.3	-1.5	-1.3	-1.1	-0.1	0.2	-1.3	-1.5	-0.1	-1.0	-0.9
Illnesses of father: None of the above (group 1)	1.3	1.6	5.1	2.1	1.6	0.6	-0.1	0.5	2.3	1.7	0.3	0.1	-0.8
Smoking status: Current	0.4	0.6	1.5	-1.0	0.5	-1.2	0.3	-0.4	-1.2	-0.5	0.0	-1.0	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	2.3	1.5	0.9	1.2	-1.3	0.3	1.3	1.4	0.4	-0.5	-0.3
Whole body water mass	0.5	2.8	9.8	-1.7	-0.3	-0.4	-1.8	-1.3	-2.2	-0.4	-0.9	2.2	3.1
Leg predicted mass (right)	0.4	2.3	6.1	-1.9	-0.6	-0.4	-1.4	-1.0	-2.2	-0.7	-0.7	2.1	2.5
Arm fat mass (left)	1.1	4.4	9.3	-3.1	-2.1	-1.8	-1.5	-2.1	-2.9	-2.9	-1.8	0.1	-0.8
Number of self-reported non-cancer illnesses	1.2	2.1	6.4	0.2	0.8	-1.8	-1.9	-2.5	0.1	0.0	-2.0	-1.8	0.0
Average weekly champagne plus white wine intake	0.3	0.4	1.5	0.3	-0.6	-0.4	-0.6	-1.1	0.2	0.4	-1.2	-0.6	0.4
Miserableness	0.2	0.4	1.5	-0.6	-0.5	-1.2	-0.1	-0.7	-0.6	-0.4	-0.4	-0.8	0.5
Guilty feelings	0.5	0.7	1.7	-1.3	-0.8	-0.5	0.6	-0.8	-1.2	-1.1	-0.7	-0.4	0.1
Wears glasses or contact lenses	2.2	2.6	5.8	-1.5	-1.3	-1.3	0.1	-0.7	-2.0	-2.1	-0.4	-2.3	-2.4
Ever taken oral contraceptive pill	0.2	0.2	0.5	0.4	-0.3	0.7	-0.5	-0.4	0.5	0.2	0.4	-0.3	-0.2
Hearing aid user	0.6	0.7	3.5	0.3	0.3	-1.0	0.0	0.3	0.1	-0.3	0.2	-1.4	-1.9
Mother’s age at death	0.3	0.4	2.4	-0.3	-0.2	0.3	1.6	-0.2	0.2	-0.5	-0.2	0.5	-0.6
Financial situation satisfaction	1.1	1.3	3.4	1.3	1.3	-0.3	0.7	-1.0	1.0	1.8	-0.8	0.1	1.7
Tinnitus: Yes, now most or all of the time	1.2	1.4	6.1	-0.6	0.0	0.1	0.3	-0.3	-0.5	-1.6	-0.2	-2.1	-2.5
Commuting to job workplace: Public transport	0.2	0.3	1.2	-0.1	0.2	-0.7	-1.1	0.3	-0.7	-0.1	0.2	0.2	-0.3
Eye problems/disorders: Glaucoma	0.8	0.9	2.8	-1.3	-0.7	-0.4	-0.6	-0.9	-1.7	-1.4	-0.6	-0.4	-0.6
Medication: Blood pressure	0.6	1.2	2.3	1.0	1.3	-1.4	-1.2	-1.2	0.7	0.1	-1.5	0.2	-1.3
Pain type(s) experienced in last month: Hip pain	0.2	0.3	1.8	-0.4	-0.1	-0.5	-0.2	-0.6	-0.2	-0.1	-0.2	-0.1	1.4
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.7	0.8	0.5	0.5	0.9	0.8	0.4	0.7	1.3	-0.7	-0.4
High cholesterol (Self-reported)	0.7	1.3	3.3	-0.7	-0.1	-1.0	-1.4	-0.9	-1.2	-1.5	-1.1	-0.6	-1.8
Medication: Bendroflumethiazide	0.7	1.1	7.1	0.7	1.1	0.4	-2.7	0.4	0.6	0.4	0.4	1.0	-0.1
Medication: Paracetamol	0.3	0.4	0.9	-0.9	-0.4	-0.4	0.6	-0.6	-0.9	-0.5	-0.5	-0.1	0.8
Medication: Lisinopril	2.4	3.1	6.0	-1.6	-0.8	-2.4	-1.4	-2.2	-0.6	-2.0	-2.1	-2.0	-1.4
Medication: Atorvastatin	0.9	1.1	2.4	1.0	1.1	-1.3	-1.0	-1.5	0.4	1.0	-1.5	0.0	0.4
Illnesses of father: High blood pressure	0.8	1.0	3.4	-1.4	-1.1	-0.3	-0.7	-0.2	-1.9	-1.3	-0.3	-0.7	0.2
Alcohol drinker status: Never	0.4	0.5	1.2	-1.0	-0.6	-0.6	0.6	0.3	-0.6	-1.0	0.3	-0.3	-1.1
Ever smoked	1.4	2.4	9.9	2.0	3.1	-1.3	-0.0	-1.0	1.0	2.2	-0.7	-0.4	1.0
Basal metabolic rate	0.5	2.9	7.4	-2.0	-0.6	-0.6	-1.9	-1.5	-2.4	-0.7	-1.1	2.0	2.7
Leg fat percentage (left)	1.8	6.4	11.4	-2.7	-1.9	-3.0	-1.3	-2.9	-2.6	-3.4	-2.6	-1.5	-2.7
Arm fat-free mass (left)	0.5	2.5	7.7	-1.5	0.0	-0.7	-1.8	-1.5	-1.9	-0.3	-1.0	2.0	2.8
Number of operations (self-reported)	1.9	2.8	8.4	-0.5	0.7	-2.3	-0.7	-2.9	-0.7	0.0	-2.6	-2.0	1.4
Average weekly beer plus cider intake	1.2	1.7	5.1	1.1	0.4	1.6	1.3	2.3	0.7	0.8	2.1	0.0	-0.7
Irritability	0.9	1.6	2.6	1.3	1.5	1.4	-0.0	1.1	0.9	1.6	1.1	1.2	1.6
Risk taking	0.1	0.2	1.0	-0.4	-1.0	0.1	-0.1	-0.3	0.1	-0.2	0.3	-0.7	0.3
Ever had prostate specific antigen (PSA) test	2.0	2.3	6.7	-1.1	-0.7	-1.7	-2.6	-2.0	-0.6	-1.1	-1.8	-1.7	0.1
Fractured/broken bones in last 5 years	0.9	1.1	3.9	-0.7	-0.5	-0.7	-1.4	-2.0	-0.6	-0.3	-1.5	0.0	1.3
Age started oral contraceptive pill	0.6	0.8	1.9	0.2	-0.4	-1.4	-1.2	-1.1	-0.1	-0.1	-1.3	-0.4	-1.2
Diastolic blood pressure, automated reading	0.4	1.4	3.8	-1.6	-1.9	0.1	-0.6	-0.3	-1.7	-1.9	-0.1	-0.5	0.1
Ever depressed for a whole week	0.5	0.6	2.3	-1.0	-0.0	-1.1	-1.5	-0.3	-0.6	-0.5	-0.6	-0.7	0.4
Unable to work because of sickness or disability	0.4	0.6	2.0	0.7	0.3	-0.7	-0.0	-1.0	0.9	0.5	-0.7	-1.4	-0.5
Commuting to job workplace: Cycle	0.6	0.7	1.9	0.3	0.2	1.4	1.1	1.1	0.2	0.2	1.0	1.0	0.1
Myopia	0.6	0.9	2.4	-1.4	-0.5	-0.6	-0.1	-0.3	-1.6	-1.2	-0.9	1.2	0.6
Vascular/heart problems diagnosed by doctor	0.5	1.2	3.2	-0.5	-1.1	1.7	1.7	0.7	-0.3	0.5	0.7	0.7	1.8
Cholesterol lowering medication	0.9	1.3	4.4	1.0	0.4	-1.9	-0.9	-0.9	0.4	0.0	-0.9	-1.1	-2.1
Medication: Omeprazole (e.g. Zanprol)	2.2	2.7	7.2	-1.0	-0.7	-1.4	-2.6	-2.4	-1.1	-0.9	-2.7	-0.9	-0.1
Pain experienced in last month	0.5	0.8	2.4	-0.1	-0.4	1.6	-1.0	1.5	0.1	-0.2	1.4	0.5	-0.2
Supplements: Calcium	0.3	0.3	1.1	-0.4	-0.2	-0.5	-1.0	-0.3	-0.1	-0.7	0.0	-0.4	-1.1
Basal cell carcinoma (self-reported)	0.2	0.2	1.4	0.3	0.1	0.0	0.3	-0.1	0.2	-0.2	-0.4	0.1	-1.2
Heart attack/myocardial infarction (self-reported)	1.0	1.3	2.6	0.7	1.5	-1.3	-1.0	-1.6	1.0	0.4	-1.4	-1.2	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.9	1.1	2.8	-0.9	-1.1	1.7	1.0	1.1	-0.7	-0.9	1.3	0.2	-0.7
Heart disease (siblings)	0.3	0.4	1.5	-0.6	-0.3	0.1	0.4	-0.1	-0.7	-0.9	0.2	-0.8	-1.2
Alcohol drinker status: Previous	1.4	1.6	3.9	1.3	1.9	-0.5	-0.5	-1.0	2.0	0.6	-0.9	-1.0	-1.7
Pack years of smoking	2.2	3.2	8.8	-0.5	-1.4	-3.0	-0.3	-2.3	-0.4	-1.1	-2.0	-2.4	-2.2
Impedance of whole body	0.6	3.1	7.2	2.0	0.7	2.7	1.4	2.5	1.8	0.9	1.7	0.8	-1.8
Leg fat mass (left)	1.3	4.9	7.8	-2.7	-1.6	-2.5	-1.7	-2.7	-2.6	-2.8	-2.5	-0.4	-1.3
Arm predicted mass (left)	0.5	2.6	7.1	-1.8	-0.1	-1.0	-1.7	-1.7	-2.1	-0.6	-1.2	1.6	2.7