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chr17:72,536,901-77,462,467

Best TWAS P=1.22e-24 · Best GWAS P=2.44e-27 conditioned to 2.46e-12

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	LLGL2	0.07	0.01	blup	364	0.03	2.7e-04	-7.8	-6.6	3.5e-11	0.72	0.48	0.41	FALSE
2	CommonMind	Brain Pre-frontal Cortex	USP36	0.14	0.13	lasso	3	0.13	1.7e-15	8.9	-8.7	2.7e-18	-0.07	0.03	0.97	FALSE
3	GTEx	Adipose Subcutaneous	CYTH1	0.13	0.03	lasso	5	0.04	5.7e-04	9.2	5.8	6.0e-09	0.04	0.04	0.83	TRUE
4	GTEx	Brain Cerebellar Hemisphere	USP36	0.50	0.16	enet	20	0.07	5.7e-03	7.8	-7.9	3.4e-15	-0.06	0.06	0.86	FALSE
5	GTEx	Brain Cerebellar Hemisphere	GGA3	0.22	0.00	lasso	4	0.00	3.0e-01	-9.2	-7.7	1.2e-14	0.67	0.04	0.38	FALSE
6	GTEx	Brain Cerebellum	USP36	0.31	0.20	enet	18	0.13	9.7e-05	7.8	-6.6	3.8e-11	-0.05	0.05	0.85	FALSE
7	GTEx	Brain Cerebellum	TRIM65	0.34	0.14	enet	8	0.19	2.8e-06	3.7	5.2	2.0e-07	-0.05	0.28	0.04	FALSE
8	GTEx	Brain Cerebellum	SEPT9	0.26	0.15	lasso	7	0.09	1.1e-03	6.6	-6.7	3.0e-11	0.01	0.01	0.96	TRUE
9	GTEx	Brain Frontal Cortex BA9	MRPL38	0.22	0.01	enet	20	0.02	8.1e-02	-4.3	-7.0	3.0e-12	0.54	0.06	0.20	FALSE
10	GTEx	Brain Nucleus accumbens basal ganglia	USP36	0.36	0.23	lasso	5	0.20	4.8e-06	8.8	-8.8	1.2e-18	-0.05	0.03	0.96	FALSE
11	GTEx	Esophagus Mucosa	USP36	0.11	0.04	enet	13	0.06	1.1e-04	9.3	-10.2	1.2e-24	-0.04	0.02	0.98	TRUE
12	GTEx	Esophagus Muscularis	USP36	0.18	0.16	lasso	3	0.08	2.5e-05	8.9	8.2	3.3e-16	0.07	0.02	0.98	FALSE
13	GTEx	Esophagus Muscularis	LLGL2	0.23	0.17	lasso	4	0.17	2.0e-10	-4.6	-5.4	5.8e-08	0.29	1.00	0.00	FALSE
14	GTEx	Heart Left Ventricle	LLGL2	0.23	0.09	lasso	5	0.11	2.5e-06	-4.6	-5.8	7.9e-09	0.35	0.77	0.03	FALSE
15	GTEx	Muscle Skeletal	LLGL2	0.22	0.08	lasso	8	0.08	4.3e-08	-4.6	-5.1	2.8e-07	0.28	1.00	0.00	FALSE
16	GTEx	Muscle Skeletal	CYTH1	0.13	0.12	lasso	3	0.13	2.5e-12	9.2	9.1	7.6e-20	0.05	0.02	0.98	FALSE
17	GTEx	Nerve Tibial	SYNGR2	0.16	0.05	enet	23	0.05	1.7e-04	-7.7	8.3	7.9e-17	-0.05	0.29	0.06	TRUE
18	GTEx	Nerve Tibial	MIF4GD	0.09	0.01	enet	12	0.02	6.9e-03	-2.9	5.4	6.4e-08	-0.40	0.13	0.36	FALSE
19	GTEx	Pancreas	TRIM65	0.42	0.03	enet	55	0.05	5.3e-03	1.2	-5.4	7.4e-08	0.13	0.11	0.05	FALSE
20	GTEx	Pituitary	SYNGR2	0.58	0.07	lasso	10	0.07	9.2e-03	3.2	-5.3	1.3e-07	0.07	0.11	0.05	FALSE
21	GTEx	Stomach	MRPS7	0.37	-0.01	enet	20	0.03	1.5e-02	-5.8	5.3	9.6e-08	-0.48	0.11	0.61	FALSE
22	GTEx	Testis	USP36	0.32	0.24	lasso	6	0.26	6.2e-12	7.4	-8.4	4.6e-17	-0.04	0.05	0.95	FALSE
23	GTEx	Testis	LLGL2	0.17	0.05	enet	15	0.13	2.4e-06	-2.1	5.3	1.2e-07	-0.53	0.16	0.56	FALSE
24	GTEx	Thyroid	USP36	0.21	0.15	enet	45	0.16	1.6e-12	8.8	-9.0	2.2e-19	-0.05	0.14	0.86	FALSE
25	GTEx	Thyroid	CYTH1	0.24	0.07	lasso	11	0.06	3.4e-05	9.0	8.2	3.3e-16	0.04	0.06	0.94	FALSE
26	GTEx	Vagina	UBE2O	0.48	-0.01	enet	59	0.04	3.8e-02	-2.2	5.3	1.4e-07	0.05	0.05	0.22	TRUE
27	GTEx	Whole Blood	MIF4GD	0.07	0.06	lasso	4	0.04	1.2e-04	-6.0	5.8	7.2e-09	-0.60	0.24	0.70	FALSE
28	NTR	Blood	GRB2	0.01	0.00	bslmm	372	0.00	4.7e-02	-2.4	5.7	1.3e-08	-0.55	0.11	0.18	FALSE
29	NTR	Blood	LLGL2	0.01	0.00	bslmm	354	0.00	2.0e-02	-3.4	-5.5	4.1e-08	0.16	0.06	0.05	TRUE
30	YFS	Blood	MRPL38	0.10	0.00	enet	34	0.03	4.3e-11	-3.1	-5.4	7.2e-08	0.01	0.13	0.03	TRUE
31	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TIMP2	0.06	0.01	blup	76	0.02	3.4e-03	6.2	-9.2	4.7e-20	-0.06	0.03	0.23	TRUE
32	The Cancer Genome Atlas	Breast Invasive Carcinoma	GRB2	0.02	0.00	blup	43	0.01	4.6e-03	-7.8	-8.6	8.6e-18	0.89	0.01	0.84	TRUE
33	The Cancer Genome Atlas	Breast Invasive Carcinoma	MIF4GD	0.01	0.00	blup	28	0.01	6.0e-03	-2.6	5.8	8.3e-09	-0.66	0.02	0.52	FALSE
34	The Cancer Genome Atlas	Breast Invasive Carcinoma	SYNGR2	0.05	0.01	lasso	3	0.02	9.8e-06	4.9	-5.6	2.2e-08	0.05	0.74	0.01	FALSE
35	The Cancer Genome Atlas	Brain Lower Grade Glioma	USP36	0.04	0.00	blup	57	0.01	2.9e-02	9.3	-7.4	1.3e-13	-0.05	0.01	0.56	FALSE
36	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	SLC25A19	0.12	0.16	enet	8	0.18	8.0e-09	-6.6	6.9	4.8e-12	-0.69	0.80	0.20	FALSE
37	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	NUP85	0.08	0.05	lasso	3	0.05	4.6e-03	-6.0	-5.8	6.8e-09	0.64	0.02	0.22	FALSE
38	The Cancer Genome Atlas	Rectum Adenocarcinoma	EPR1	0.18	0.07	blup	61	0.08	6.9e-03	3.5	5.3	9.8e-08	-0.05	0.02	0.09	FALSE
39	The Cancer Genome Atlas	Testicular Germ Cell Tumors	USP36	0.10	0.02	lasso	4	0.05	6.6e-03	8.8	-6.8	1.2e-11	0.00	0.02	0.83	FALSE
40	The Cancer Genome Atlas	Thyroid Carcinoma	CYTH1	0.11	0.09	lasso	4	0.08	2.4e-08	-5.5	5.4	7.3e-08	0.02	0.88	0.11	FALSE
41	The Cancer Genome Atlas	Thyroid Carcinoma	TIMP2	0.06	0.01	blup	77	0.02	1.2e-02	4.2	7.9	4.0e-15	0.03	0.04	0.17	TRUE