Hub : Genes

SLC25A19

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Cortex 0.4770 0.1260 4.7e-03 0.007 NA 0.027 NA -0.006 2.0e-01 NA 6.0e-02 NA 4.9e-01
2 GTEx Liver 0.1800 0.0680 1.8e-03 0.151 NA 0.061 NA 0.110 5.3e-05 NA 8.8e-03 NA 5.6e-04
3 YFS Blood 0.0687 0.0167 5.6e-16 0.062 0.054 0.054 0.06 0.056 1.9e-19 4.3e-17 4.4e-17 5.7e-19 1.2e-17
4 TCGA Liver Hepatocellular Carcinoma 0.1210 0.0560 4.3e-08 0.164 0.167 0.179 NA 0.171 3.9e-08 2.6e-08 8.0e-09 NA 1.8e-08
5 TCGA Lung Squamous Cell Carcinoma 0.0770 0.0477 1.4e-05 0.058 0.039 0.024 NA 0.046 3.6e-07 2.9e-05 9.1e-04 NA 5.2e-06
6 TCGA Pancreatic Adenocarcinoma 0.1050 0.0660 2.2e-03 0.107 0.037 0.071 NA 0.081 3.1e-05 1.1e-02 6.3e-04 NA 2.7e-04
7 TCGA Prostate Adenocarcinoma 0.0268 0.0182 9.7e-03 0.030 0.015 0.015 NA 0.019 3.4e-04 8.5e-03 9.0e-03 NA 3.6e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.5 0.8 3.2 0.0 1.0 -0.1 -0.1 -1.1 0.5 -1.8
Bipolar Disorder or Schizophrenia 0.5 1.3 4.4 0.0 0.9 -1.0 1.0 0.2 1.4 -2.1
Depressed Affect (Nagel 2018) 0.6 1.3 3.0 0.0 -0.8 1.4 -1.7 -1.4 -0.9 0.8
Depression (Nagel 2018) 0.3 0.4 1.0 0.0 1.0 -0.6 0.5 -0.5 -0.9 -0.6
Intelligence (Savage-Jansen 2018) 0.2 0.6 2.2 0.0 0.9 -1.5 0.5 0.7 0.5 -0.5
Neuroticism (Nagel 2018) 1.3 3.1 8.1 0.0 -1.0 2.1 -1.6 -2.8 -2.4 0.4
Schizophrenia (2018) 0.6 1.1 1.8 0.0 0.3 -1.2 1.3 1.2 1.3 -1.2
Schizophrenia vs Biploar Disorder 0.3 0.4 1.1 0.0 -0.1 -1.0 0.6 1.1 0.5 0.1
Worry (Nagel 2018) 1.8 3.8 10.4 0.0 -0.9 2.1 -1.1 -3.1 -3.2 -0.1
Alzheimer’s Disease (in mother) 0.1 0.1 0.5 0.0 0.7 -0.5 -0.2 0.2 -0.3 0.1
Alzheimer’s Disease (in father) 0.7 0.7 1.5 0.0 -0.5 1.2 -1.1 -1.0 -0.8 0.8
Alzheimer’s Disease (including proxy) 0.2 0.2 0.7 0.0 -0.2 0.4 -0.8 -0.4 -0.5 0.5
Crohns Disease (2017) 0.2 0.4 1.2 0.0 0.7 -1.1 0.9 0.2 0.4 -0.4
Irritable Bowel Disease (IBD) 0.0 0.1 0.5 0.0 -0.2 -0.2 0.7 0.0 -0.2 -0.2
Ulcerative Colitis (UC) 0.1 0.3 0.5 0.0 -0.7 0.6 0.5 -0.2 -0.7 -0.3
Major Depression (MDD) 0.5 0.6 1.6 0.0 1.3 -0.5 0.6 0.6 0.9 -1.1
Reaction Time 0.6 1.1 3.8 0.0 -0.6 0.3 -0.1 2.0 0.6 1.7
Verbal and Numeric Reasoning (VNR) 0.2 0.5 1.5 0.0 1.2 -1.1 0.1 0.3 0.2 -0.8
Breast Cancer 1.6 3.8 10.0 0.0 -2.6 1.8 -2.2 -0.9 -1.2 3.2
Ovarian Cancer 1.0 1.3 2.2 0.0 -1.3 1.2 -1.5 -1.5 -1.1 0.8
Prostate Cancer 1.5 2.1 4.3 0.0 -1.0 1.2 -2.1 -2.0 -1.8 1.0
Age at First Birth 0.2 0.3 1.1 0.0 -0.3 0.9 -1.0 -0.1 -0.0 -0.4
Bipolar Disorder (2011) 0.2 0.2 0.7 0.0 0.0 0.0 -0.6 -0.7 -0.8 -0.0
Body Mass Index (BMI) (2010) 1.3 1.8 5.6 0.0 2.4 -1.4 1.2 -0.0 0.1 -1.9
Coronary Artery Disease (CAD) 3.0 3.6 8.0 0.0 -2.8 1.5 -1.5 -2.0 -2.3 1.8
Crohns Disease (2012) 0.1 0.2 0.4 0.0 0.6 -0.7 0.3 0.2 0.2 -0.5
Mean Putamen Volume 0.4 0.5 1.8 0.0 -0.5 -0.3 0.5 1.0 0.5 1.3
Fasting Glucose 0.3 0.4 1.0 0.0 0.5 -1.0 0.2 0.5 1.0 -0.4
HbA1C 0.6 0.7 3.7 0.0 -0.6 -0.2 0.7 0.3 -0.2 1.9
HDL Cholesterol 0.5 0.9 2.1 0.0 -0.7 -0.3 0.4 1.5 1.4 1.1
LDL Cholesterol 0.6 1.0 2.5 0.0 -0.1 1.6 -1.4 -1.2 -1.0 -0.1
Lupus 3.7 5.5 14.7 0.0 1.3 -3.0 3.8 2.7 2.0 -1.5
Neuroticism (2016) 0.8 1.1 3.9 0.0 -0.1 0.6 -1.1 -2.0 -1.3 -0.9
Primary Biliary Cirrhosis 0.2 0.3 1.1 0.0 -0.3 0.2 0.1 -0.7 -0.5 -1.0
Rheumatoid Arthritis 0.4 0.5 1.0 0.0 0.8 -0.8 0.7 1.0 0.8 0.4
Schizophrenia (2014) 1.3 2.8 6.0 0.0 1.2 -1.7 1.9 1.7 1.7 -2.5
Triglycerides 1.2 2.0 6.4 0.0 2.3 -1.0 0.9 -0.5 0.2 -2.5
Type 2 Diabetes (T2D) (2012) 0.0 0.1 0.2 0.0 -0.1 0.3 -0.2 -0.4 -0.2 -0.1
Ulcerative Colitis 0.1 0.2 0.7 0.0 -0.8 0.6 0.3 0.3 -0.4 0.4
Blood Eosinophil Count 0.2 1.7 3.7 0.0 1.6 -1.4 1.9 0.3 0.7 -1.8
Blood Platelet Count 0.1 1.0 2.3 0.0 -0.9 1.4 -0.8 -0.9 -1.5 -0.6
Blood Red Count 0.2 2.2 4.7 0.0 1.2 -0.5 2.2 2.2 1.7 -1.2
Blood White Count 0.2 1.2 3.7 0.0 0.9 -0.2 1.8 0.1 -1.0 -1.9
Heel T-Score 0.4 3.5 11.0 0.0 0.7 -1.1 0.2 3.0 3.3 1.7
BMI 0.2 1.2 6.1 0.0 1.2 -0.8 0.2 0.0 0.3 -2.5
Height 0.7 13.4 47.7 0.0 2.1 -3.4 6.9 3.8 3.0 -2.6
Waist Hip Ratio (WHR) 4.9 22.0 42.8 0.0 5.2 -4.7 6.5 4.7 4.4 -4.6
Systolic Blood Pressure 0.2 0.8 1.8 0.0 0.9 -0.9 0.9 0.5 1.3 -1.1
Smoking Status 1.1 2.5 6.1 0.0 -1.5 1.9 -2.5 -1.2 -1.4 1.5
Allergy or Eczema 0.8 2.1 4.2 0.0 -2.0 0.7 -1.6 -1.6 -1.2 1.8
Cardiovascular Disease 1.2 4.0 8.8 0.0 2.5 -2.6 2.1 0.4 1.2 -3.0
Hypothyroidism (self reported) 0.4 0.9 2.4 0.0 -1.0 0.9 -1.0 -1.6 -1.2 0.2
Respiratory disease 1.6 3.6 5.4 0.0 1.7 -2.1 2.3 2.0 2.2 -1.8
Type 2 Diabetes (T2D) (2018) 0.4 0.7 2.8 0.0 0.2 -1.7 1.2 -0.5 -0.2 -0.3
Lung FEV1/FVC ratio 0.2 1.2 3.3 0.0 -0.8 0.1 -1.6 -1.8 -1.3 -0.6
Lung FVC 3.2 16.5 33.8 0.0 -4.5 4.5 -5.8 -3.3 -3.0 4.7
Neuroticism 1.2 3.0 5.7 0.0 -1.4 1.9 -1.7 -2.4 -2.3 1.1
Chronotype (morning person) 0.3 0.8 2.3 0.0 -0.5 0.6 0.4 -1.5 -1.5 -0.3
Hair Pigment 0.3 9.5 22.1 0.0 3.8 -3.3 4.7 2.5 2.1 -2.9
Tanning 0.6 7.9 16.7 0.0 -3.6 2.9 -4.1 -1.6 -1.1 3.6
Hand grip strength (left) 2.6 6.9 12.4 0.0 2.7 -3.5 3.1 2.0 2.7 -2.8
Number of treatments/medications taken 0.8 1.5 5.4 0.0 1.4 -1.4 1.0 -0.5 0.1 -2.3
Average weekly spirits intake 0.3 0.4 1.2 0.0 0.6 -0.5 0.6 1.1 0.5 -0.6
Sensitivity / hurt feelings 0.3 0.5 1.6 0.0 1.3 -0.6 0.9 0.5 0.6 -0.5
Frequency of depressed mood in last 2 weeks 0.1 0.1 0.4 0.0 0.4 -0.6 0.2 -0.2 -0.5 -0.1
Hearing difficulty/problems: Yes 0.1 0.1 0.6 0.0 0.3 0.3 0.3 0.1 -0.1 -0.8
Relative age of first facial hair 0.0 0.0 0.2 0.0 -0.0 0.2 0.3 0.4 0.1 0.0
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 1.3 0.0 -1.1 0.3 0.4 0.9 -0.2 1.0
Ever used hormone-replacement therapy (HRT) 1.2 1.5 3.6 0.0 -1.6 1.9 -1.4 -0.9 -0.7 1.2
Ever had hysterectomy (womb removed) 1.7 2.0 6.4 0.0 -2.0 1.3 -1.1 0.0 -0.4 2.5
Systolic blood pressure, automated reading 0.7 1.9 4.1 0.0 1.2 -1.2 1.3 1.5 2.0 -1.6
Eye problems/disorders: Diabetes related eye disease 1.1 1.2 3.3 0.0 0.7 -1.8 1.3 1.0 1.4 -0.4
Angina 0.7 0.9 2.0 0.0 -0.9 1.4 -1.1 -1.2 -1.0 0.1
Medication for hormone replacement therapy 0.2 0.2 0.7 0.0 0.3 -0.8 0.6 0.3 0.5 -0.3
Vitamin and mineral supplements 0.5 0.7 1.9 0.0 1.4 -1.2 0.6 0.2 -0.1 -1.2
Supplements: Zinc 0.2 0.2 0.5 0.0 0.3 -0.2 0.7 0.6 0.5 0.1
Medication: Co-codamol 0.1 0.2 0.5 0.0 -0.3 0.7 -0.5 -0.5 -0.3 0.1
Medication: Metformin 0.7 0.9 3.6 0.0 0.6 -1.9 1.1 0.2 0.7 -0.9
Diabetes (father) 1.6 2.0 4.9 0.0 0.6 -1.6 2.2 1.9 1.5 -0.2
Diabetes (mother) 0.4 0.6 1.7 0.0 0.6 -0.6 1.3 0.3 -0.3 -1.2
Severe depression (siblings) 0.1 0.1 0.2 0.0 -0.3 0.0 -0.1 0.4 0.4 0.4
Pack years adult smoking proportion 0.5 0.8 2.2 0.0 0.5 -0.5 1.2 1.2 1.5 -0.3
Impedance of leg (right) 0.1 0.5 1.7 0.0 0.7 -0.4 1.3 -0.0 0.4 -0.8
Leg fat-free mass (left) 0.3 1.9 4.5 0.0 1.1 -1.0 2.1 1.2 0.7 -2.1
Trunk fat percentage 0.7 2.7 10.4 0.0 1.9 -0.8 1.6 0.9 0.9 -3.2
Hand grip strength (right) 1.9 5.1 8.8 0.0 2.2 -3.0 2.5 2.2 2.7 -1.9
Townsend deprivation index at recruitment 1.1 1.5 5.2 0.0 -1.6 1.2 -1.0 0.5 -0.0 2.3
Current tobacco smoking 0.5 0.8 1.3 0.0 1.1 -1.0 0.7 1.0 0.8 -0.9
Average weekly fortified wine intake 0.6 0.7 2.5 0.0 1.6 -0.6 0.7 0.1 0.2 -1.3
Maternal smoking around birth 1.2 1.8 3.7 0.0 1.4 -1.4 0.9 1.9 1.7 -1.0
Fed-up feelings 0.4 0.7 2.4 0.0 -0.5 0.3 -1.6 -1.1 -0.8 0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 1.3 0.0 0.7 -1.1 0.7 0.0 -0.6 -0.5
Relative age voice broke 0.9 1.3 2.1 0.0 -1.1 1.4 -1.3 -1.2 -1.4 1.1
Taking other prescription medications 0.4 0.7 2.5 0.0 -0.1 0.0 0.0 -1.6 -1.3 -0.7
Age when periods started (menarche) 1.4 3.4 7.2 0.0 -2.7 1.8 -2.1 -0.9 -1.3 2.6
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 1.6 0.0 -1.3 1.1 -1.3 -0.3 -0.1 1.1
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.4 1.1 0.0 0.4 -0.7 0.5 0.9 1.1 -0.0
Tinnitus: Yes, but not now, but have in the past 0.3 0.4 1.5 0.0 0.8 -0.3 0.4 -0.0 0.1 -1.2
Qualifications: CSEs or equivalent 1.0 1.4 4.4 0.0 1.0 -1.4 2.1 1.0 0.5 -1.0
Serious illness, injury or assault to yourself 1.3 1.6 3.3 0.0 1.8 -1.4 1.6 0.2 0.5 -1.8
High blood pressure 1.7 4.9 9.8 0.0 2.7 -2.8 2.7 0.8 1.0 -3.1
Hayfever, allergic rhinitis or eczema 0.8 1.7 6.2 0.0 -1.2 0.2 -1.4 -2.5 -1.2 0.8
Multivitamins +/- minerals 0.2 0.2 0.7 0.0 -0.9 0.4 -0.3 -0.3 0.5 0.6
Stomach or abdominal pain in last month 0.5 0.6 1.6 0.0 0.7 -0.1 0.1 -1.0 -1.1 -1.3
Supplements: Glucosamine 1.0 1.2 2.8 0.0 -1.7 1.6 -1.0 -0.5 -0.6 1.3
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 1.5 0.0 -0.3 0.3 -0.7 -1.2 -0.9 0.5
Medication: Atenolol 0.1 0.1 0.3 0.0 -0.2 0.6 -0.2 -0.2 -0.3 0.4
Medication: Levothyroxine sodium 0.7 1.2 2.2 0.0 -1.5 1.0 -1.0 -1.5 -1.1 0.9
Sitting height 0.1 0.8 2.4 0.0 -1.6 1.0 -0.4 -1.0 -0.9 0.2
Chronic bronchitis/emphysema (father) 0.6 0.7 1.3 0.0 0.8 -0.9 0.7 0.6 1.2 -1.0
High blood pressure (mother) 3.0 4.2 9.2 0.0 1.8 -2.2 2.3 2.4 3.0 -1.1
Body mass index (BMI) 0.1 0.5 3.1 0.0 0.5 0.0 -0.1 0.2 0.0 -1.8
Impedance of leg (left) 0.0 0.2 0.5 0.0 0.2 -0.0 0.6 -0.6 0.2 -0.7
Leg predicted mass (left) 0.3 1.7 4.3 0.0 1.1 -0.9 2.0 1.1 0.6 -2.1
Trunk fat mass 0.9 3.8 12.8 0.0 2.1 -1.2 2.3 1.3 1.1 -3.6
Waist circumference 1.3 4.8 12.5 0.0 2.4 -1.7 2.7 1.7 1.4 -3.5
Number of incorrect matches in round 0.5 0.9 1.8 0.0 -1.4 1.3 -0.9 -0.1 -0.9 1.2
Past tobacco smoking 1.4 2.5 5.6 0.0 1.5 -2.1 2.4 1.4 1.6 -1.2
Alcohol usually taken with meals 0.5 0.9 1.6 0.0 -0.3 -1.0 0.9 1.3 1.3 1.0
Nervous feelings 1.3 2.3 6.2 0.0 -1.2 1.6 -0.9 -2.3 -2.5 0.2
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.4 1.3 0.0 0.2 -1.1 0.8 0.5 0.9 -0.3
Hearing difficulty/problems with background noise 0.1 0.1 0.5 0.0 -0.2 0.7 0.3 0.6 0.3 0.1
Hair/balding pattern: Pattern 2 2.3 2.9 5.7 0.0 2.4 -1.9 1.5 1.2 1.4 -2.3
Had menopause 0.8 1.0 3.3 0.0 -1.1 1.2 -0.7 0.7 -0.1 1.8
Had other major operations 0.2 0.2 0.7 0.0 0.7 -0.1 -0.1 0.0 0.6 -0.8
Forced vital capacity (FVC) 0.7 2.9 4.8 0.0 -2.1 1.8 -1.9 -2.2 -1.5 1.3
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.2 3.0 0.0 0.7 -1.4 1.0 1.1 1.7 -0.5
Ever unenthusiastic/disinterested for a whole week 0.2 0.3 0.9 0.0 -0.6 0.5 -0.6 -0.2 -0.0 1.0
Qualifications: None of the above 0.2 0.4 1.3 0.0 -0.4 0.8 0.0 1.1 0.6 0.0
Financial difficulties in last 2 years 0.2 0.3 0.7 0.0 0.3 -0.8 0.3 0.1 -0.6 -0.9
Mouth/teeth dental problems 0.9 1.3 3.3 0.0 1.4 -0.5 1.5 0.8 1.8 -0.9
Heart attack 0.2 0.3 0.9 0.0 -0.4 0.3 -0.6 -0.9 -0.6 0.3
Allergy 0.2 0.4 2.2 0.0 -0.1 0.6 0.2 1.5 0.1 0.6
Pain all over the body in last month 1.0 1.1 4.2 0.0 -2.1 0.7 -0.6 -0.2 -0.5 1.6
Diabetes (self-reported) 0.7 1.1 3.6 0.0 0.1 -1.9 1.4 1.2 0.9 0.2
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 0.8 0.0 -0.7 0.5 -0.8 -0.8 -0.9 0.9
Medication: Ramipril 0.5 0.6 1.7 0.0 -0.6 0.0 -1.1 -1.3 -0.5 -0.8
Medication: Simvastatin 0.5 0.7 1.7 0.0 0.9 -1.0 1.1 -0.0 0.2 -1.3
Fluid intelligence score 0.0 0.1 0.3 0.0 0.2 -0.6 -0.4 -0.1 -0.1 0.4
Illnesses of siblings 0.1 0.1 0.3 0.0 0.5 0.5 0.1 -0.0 -0.5 0.1
Neuroticism score 1.3 2.7 7.3 0.0 -0.7 1.6 -1.7 -2.7 -2.3 0.4
Weight 0.4 2.0 7.7 0.0 1.1 -0.9 1.9 0.8 0.6 -2.8
Impedance of arm (right) 0.1 0.3 0.9 0.0 0.5 0.2 0.9 -0.3 -0.5 -0.5
Arm fat percentage (right) 0.2 0.9 5.0 0.0 1.1 0.1 0.4 0.2 -0.1 -2.2
Trunk fat-free mass 0.3 1.5 5.0 0.0 0.6 -0.9 2.2 1.1 0.7 -1.6
Hip circumference 0.1 0.5 1.2 0.0 -0.9 1.1 -0.5 -0.6 -0.8 -0.6
Time employed in main current job 0.2 0.2 1.0 0.0 -0.1 1.0 -0.5 -0.5 -0.2 0.4
Alcohol intake versus 10 years previously 1.3 2.0 4.1 0.0 1.2 -1.3 1.7 1.8 2.0 -0.7
Father’s age at death 0.2 0.3 0.8 0.0 -0.1 -0.7 -0.3 0.5 0.5 0.9
Worrier / anxious feelings 0.5 0.9 2.6 0.0 -0.3 1.3 -0.5 -1.4 -1.6 0.4
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.3 0.9 0.0 -0.8 0.1 -0.3 -1.0 -0.7 -0.1
Falls in the last year 0.6 0.8 3.4 0.0 -0.4 0.8 -0.3 -1.0 -1.9 0.4
Hair/balding pattern: Pattern 3 0.7 1.0 1.8 0.0 -1.1 0.7 -1.1 -1.4 -0.9 1.2
Number of live births 0.3 0.4 1.1 0.0 0.7 0.2 0.1 -0.7 -1.1 -0.9
Forced expiratory volume in 1-second (FEV1) 1.0 3.5 6.0 0.0 -2.4 1.8 -2.3 -2.3 -1.7 1.3
Pulse rate 0.1 0.2 1.3 0.0 -0.2 -1.1 0.3 -0.4 -0.3 -0.3
Happiness 2.2 2.6 5.8 0.0 -1.3 1.8 -2.4 -2.1 -1.8 0.3
Noisy workplace 0.6 0.7 1.8 0.0 0.7 -1.1 0.8 0.8 1.4 -0.5
Qualifications: A levels/AS levels or equivalent 0.2 0.5 1.5 0.0 1.1 -1.2 0.3 -0.5 0.2 -0.6
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.5 1.7 0.0 0.2 0.2 -0.4 -1.3 -1.3 -0.3
Mouth/teeth dental problems: Dentures 0.1 0.1 0.6 0.0 0.2 -0.0 -0.1 -0.3 -0.8 -0.4
Asthma 2.2 4.3 10.3 0.0 2.2 -2.3 2.2 1.1 1.8 -3.2
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.8 1.7 0.0 -1.3 0.6 -0.9 -1.3 -0.9 0.6
Medication: Cholesterol lowering 0.2 0.3 0.8 0.0 0.4 -0.7 0.7 -0.3 -0.1 -0.9
Depression (self-reported) 0.4 0.4 1.5 0.0 0.6 -0.8 -0.1 0.5 1.2 0.5
Medication: Lansoprazole 0.9 1.0 2.2 0.0 0.8 -1.1 1.5 1.0 1.1 -0.9
Prospective memory result 0.2 0.2 0.8 0.0 0.2 -0.4 0.9 0.3 0.4 0.0
Lung cancer (father) 0.1 0.1 0.4 0.0 -0.3 -0.1 0.4 -0.0 0.6 0.0
Illnesses of mother 1.0 1.2 3.1 0.0 -0.9 1.5 -0.3 -1.4 -1.8 0.4
Forced expiratory volume in 1-second (FEV1), Best measure 2.2 7.0 12.5 0.0 -3.2 2.4 -3.1 -3.5 -2.8 1.7
Pulse wave Arterial Stiffness index 0.9 1.1 2.8 0.0 1.1 -0.7 1.7 -0.4 -0.6 -1.6
Impedance of arm (left) 0.0 0.1 0.5 0.0 0.4 0.1 0.7 -0.3 -0.2 -0.1
Arm fat mass (right) 0.4 1.5 6.8 0.0 1.2 -0.4 1.1 0.6 0.4 -2.6
Trunk predicted mass 0.2 1.3 4.5 0.0 0.5 -0.8 2.1 1.0 0.6 -1.5
Standing height 0.6 5.9 22.0 0.0 1.7 -2.1 4.7 1.6 1.5 -2.7
Length of working week for main job 1.6 1.8 3.4 0.0 -1.1 1.3 -1.8 -1.3 -1.9 1.1
Exposure to tobacco smoke at home 0.1 0.1 0.1 0.0 -0.1 -0.4 -0.0 0.3 0.3 -0.3
Breastfed as a baby 0.1 0.1 0.3 0.0 -0.3 0.3 0.5 0.5 0.2 -0.1
Tense / ‘highly strung’ 1.3 2.2 7.0 0.0 0.2 0.6 -0.8 -2.6 -2.3 -1.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 2.2 0.0 0.3 -0.1 -0.5 -1.5 -0.3 -0.8
Hair/balding pattern: Pattern 4 0.3 0.8 2.2 0.0 -0.3 0.7 0.8 1.5 1.2 0.8
Birth weight of first child 0.2 0.3 0.9 0.0 0.6 -0.5 0.6 -0.6 -0.3 -0.9
Peak expiratory flow (PEF) 0.3 0.7 1.6 0.0 -1.1 0.6 -1.2 -1.3 -0.8 0.3
Pulse wave reflection index 0.4 0.5 1.5 0.0 1.2 -0.6 1.1 -0.2 -0.1 -0.6
Ever highly irritable/argumentative for 2 days 0.6 0.7 1.1 0.0 -0.9 1.0 -0.9 -0.7 -1.0 1.0
Loud music exposure frequency 0.3 0.3 0.8 0.0 -0.4 -0.6 -0.3 0.2 0.9 0.9
Qualifications: O levels/GCSEs or equivalent 1.2 1.9 4.2 0.0 -0.9 1.3 -1.8 -2.0 -1.6 0.8
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 1.2 0.0 -0.8 -0.4 -0.4 0.9 0.6 1.1
Blood clot in the leg (DVT) 0.1 0.1 0.5 0.0 0.1 0.1 0.2 -0.7 0.4 -0.6
Medication: Paracetamol 0.1 0.2 0.4 0.0 -0.2 0.5 -0.6 -0.7 0.2 -0.3
Headache pain in last month 0.1 0.2 1.0 0.0 0.5 -0.2 -0.0 -0.5 -0.3 -1.0
Medication for cholesterol, blood pressure or diabetes 0.5 0.9 2.7 0.0 -0.9 0.6 -0.7 1.0 0.7 1.6
Glaucoma (self-reported) 0.9 1.0 3.0 0.0 1.3 -1.0 1.1 0.6 0.1 -1.7
Gout (self-reported) 0.5 0.7 1.7 0.0 0.6 -0.6 1.2 0.5 0.7 -1.3
Hypothyroidism/myxoedema (self-reported) 0.3 0.5 1.4 0.0 -1.0 0.7 -0.7 -1.2 -0.5 -0.0
Medication: Amlodipine 0.1 0.2 0.8 0.0 -0.4 -0.1 -0.6 -0.9 -0.1 0.3
Medication: Ventolin 100micrograms inhaler 0.2 0.2 1.0 0.0 0.4 -0.3 0.6 -0.1 -0.0 -1.0
Birth weight 2.0 4.3 7.8 0.0 2.8 -2.0 2.8 1.7 1.6 -2.3
Chronic bronchitis/emphysema (mother) 0.1 0.1 0.2 0.0 -0.4 -0.2 -0.4 0.4 0.5 0.4
High blood pressure (siblings) 0.1 0.1 0.3 0.0 0.2 -0.3 -0.4 -0.2 0.2 -0.6
Forced vital capacity (FVC), Best measure 1.7 6.2 11.0 0.0 -3.0 2.4 -2.8 -3.3 -2.6 1.7
Body fat percentage 0.4 1.7 7.9 0.0 1.4 -0.3 1.0 0.6 0.5 -2.8
Leg fat percentage (right) 0.4 1.4 5.7 0.0 1.3 -0.2 1.1 0.9 0.5 -2.4
Arm fat-free mass (right) 0.4 1.9 4.4 0.0 0.9 -1.1 2.1 1.3 1.1 -2.1
Exposure to tobacco smoke outside home 0.8 1.1 2.5 0.0 -1.2 0.8 -1.6 -1.3 -0.9 1.0
Comparative body size at age 10 1.4 3.9 8.1 0.0 1.8 -2.5 2.2 2.8 2.1 -0.7
Number of full brothers 0.3 0.4 0.9 0.0 -0.1 0.4 -0.4 -1.0 -0.7 -0.9
Worry too long after embarrassment 0.3 0.5 1.3 0.0 0.2 0.6 -0.1 -1.0 -1.1 -0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.2 0.9 0.0 0.4 -0.9 0.0 -0.4 0.4 0.3
Wheeze or whistling in the chest in last year 1.7 3.1 5.6 0.0 1.7 -2.4 2.2 1.5 1.8 -1.6
Number of children fathered 1.3 1.4 2.8 0.0 1.2 -1.7 1.6 0.4 1.3 -1.2
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.3 1.2 0.0 1.1 0.1 -0.2 -0.7 -0.5 -0.6
Age at first live birth 0.3 0.5 1.4 0.0 1.2 -1.2 0.6 0.3 0.5 -0.5
Pulse wave peak to peak time 0.8 1.0 2.4 0.0 -1.1 0.6 -1.4 0.4 0.6 1.6
Health satisfaction 2.1 2.7 6.0 0.0 -1.0 2.1 -1.2 -2.5 -2.3 -1.1
Shortness of breath walking on level ground 1.4 1.7 3.5 0.0 1.8 -1.4 1.7 0.3 0.6 -1.9
Qualifications: College or University degree 0.2 0.7 2.1 0.0 -0.4 1.5 -1.1 -1.0 -0.6 0.5
Eye problems/disorders: None of the above 0.7 0.8 1.9 0.0 -1.0 1.1 -1.3 -0.1 -0.0 1.4
Mouth/teeth dental problems: Loose teeth 0.1 0.1 0.3 0.0 -0.3 -0.0 -0.3 0.6 0.3 0.2
Emphysema/chronic bronchitis 0.5 0.6 1.5 0.0 0.5 -0.5 1.2 1.1 1.0 -0.1
Medication for pain relief, constipation, heartburn 0.6 1.1 3.6 0.0 0.6 -0.2 0.8 1.9 1.5 0.8
Neck or shoulder pain in last month 0.9 1.3 4.6 0.0 1.2 -1.0 1.0 -0.7 -0.8 -2.1
Medication: Blood pressure 0.4 0.7 2.3 0.0 1.0 -0.5 0.9 -0.3 -0.4 -1.5
Angina (self-reported) 0.5 0.7 1.6 0.0 -0.8 1.2 -1.0 -1.0 -0.9 0.0
Migraine (self-reported) 0.1 0.1 0.3 0.0 0.0 0.1 0.5 -0.4 0.2 -0.1
Medication: Ibuprofen 0.2 0.3 1.1 0.0 -0.3 0.1 -0.9 -1.1 -0.1 -0.0
Medication: Allopurinol 0.6 0.8 2.0 0.0 1.0 -0.8 1.2 0.3 0.6 -1.4
Medication: Omeprazole 0.6 0.7 1.7 0.0 0.6 0.3 0.1 -1.3 -1.0 -1.3
Medication: Seretide 50 evohaler 0.9 1.1 3.8 0.0 0.4 -0.7 1.1 2.0 1.3 -0.4
Mean time to correctly identify matches 1.1 2.0 8.8 0.0 0.7 -0.7 1.1 3.0 1.6 0.7
Heart disease (mother) 0.8 0.9 2.5 0.0 0.6 -1.6 1.1 0.9 1.3 -0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.6 1.9 3.2 0.0 1.2 -1.6 1.8 1.3 1.7 -1.1
Whole body fat mass 0.7 2.9 11.5 0.0 1.8 -0.9 1.8 0.9 0.8 -3.4
Leg fat mass (right) 0.6 2.2 9.3 0.0 1.5 -0.6 1.6 0.8 0.5 -3.0
Arm predicted mass (right) 0.3 1.7 4.2 0.0 0.8 -1.1 2.0 1.0 0.9 -2.0
Pulse rate, automated reading 0.2 0.7 2.7 0.0 -0.1 -0.4 -0.2 -1.4 -1.6 -0.5
Alcohol intake frequency. 2.1 5.0 11.4 0.0 1.4 -2.1 3.1 3.4 2.4 -1.1
Comparative height size at age 10 1.4 7.9 22.0 0.0 2.5 -2.8 4.7 1.9 1.7 -3.5
Number of full sisters 0.2 0.2 0.5 0.0 0.3 0.4 0.6 0.4 0.5 -0.7
Suffer from ‘nerves’ 1.2 1.9 5.6 0.0 0.1 0.8 -0.8 -2.4 -2.2 -1.2
Overall health rating 0.7 1.5 4.8 0.0 0.8 -0.6 0.6 -1.6 -1.3 -2.2
Chest pain or discomfort 2.0 2.9 7.7 0.0 -1.0 1.7 -1.7 -2.8 -2.4 -0.2
Had major operations 2.1 2.4 5.5 0.0 -1.4 1.6 -1.5 -2.4 -2.2 -0.2
Age at last live birth 1.4 2.0 5.5 0.0 2.4 -1.6 1.3 0.7 0.5 -1.9
Family relationship satisfaction 1.0 1.2 2.7 0.0 -1.0 0.9 -1.4 -1.7 -1.2 -0.6
Leg pain on walking 1.6 2.0 4.1 0.0 1.8 -0.9 1.9 1.1 1.0 -2.0
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.3 1.2 0.0 0.2 -1.1 0.4 -0.1 0.3 -0.8
Commuting to job workplace: Car/motor vehicle 5.6 6.4 9.8 0.0 3.0 -2.9 3.1 2.5 2.0 -2.7
Illness, injury, bereavement, stress in last 2 years 1.8 2.2 5.2 0.0 -2.1 1.5 -1.8 0.3 0.6 2.3
Medication: Aspirin 0.6 0.8 2.5 0.0 0.9 -1.4 0.5 -0.4 -0.1 -1.6
Supplements: Vitamin C 0.4 0.5 1.5 0.0 -1.0 1.2 0.0 0.4 -0.2 0.8
Knee pain experienced in last month 0.5 0.7 2.0 0.0 0.7 -1.4 1.3 0.5 0.6 -0.7
Hypertension (Self-reported) 1.7 4.6 9.0 0.0 2.7 -2.7 2.7 0.8 1.1 -3.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.3 1.1 0.0 0.4 -0.2 0.2 0.2 1.0 -0.9
Illnesses of father: Heart disease 0.4 0.6 2.9 0.0 0.2 -0.2 -0.4 -1.7 -0.9 -0.3
Illnesses of siblings: Diabetes 0.3 0.4 1.2 0.0 -0.9 0.1 0.8 1.1 0.5 -0.1
Smoking status: Previous 1.0 1.4 3.0 0.0 -1.3 1.6 -1.7 -0.9 -0.9 1.0
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.3 1.4 0.0 -1.2 0.4 0.4 -0.3 -0.3 0.4
Whole body fat-free mass 0.2 1.2 3.7 0.0 0.5 -0.7 1.9 0.9 0.5 -1.7
Leg fat-free mass (right) 0.2 1.0 2.9 0.0 0.6 -0.6 1.6 0.9 0.5 -1.7
Arm fat percentage (left) 0.2 0.8 4.3 0.0 1.0 0.1 0.3 0.2 -0.1 -2.1
Average weekly red wine intake 0.3 0.5 1.4 0.0 0.9 0.5 -0.1 -0.1 -1.0 -1.2
Handedness (chirality/laterality): Left-handed 2.7 3.3 5.3 0.0 -1.6 2.3 -2.0 -2.3 -2.3 0.9
Mood swings 0.1 0.2 0.4 0.0 -0.4 0.5 -0.7 -0.3 -0.4 0.4
Loneliness, isolation 0.3 0.5 1.8 0.0 -0.2 0.6 -0.6 -0.9 -1.3 -0.1
Long-standing illness, disability or infirmity 1.4 2.1 4.9 0.0 1.2 -1.6 2.2 1.1 0.5 -2.1
Ever had bowel cancer screening 0.3 0.3 0.7 0.0 0.7 -0.1 0.8 0.6 0.7 -0.2
Diabetes diagnosed by doctor 0.7 1.2 4.2 0.0 0.7 -2.0 1.6 0.6 0.7 -0.6
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.6 2.4 0.0 -0.1 0.4 -0.5 -1.2 -1.5 -0.5
Friendships satisfaction 0.4 0.5 1.3 0.0 -0.3 1.1 -1.1 -0.6 -0.2 -0.5
Qualifications: nursing, teaching 0.1 0.1 0.6 0.0 0.8 -0.2 0.1 0.0 0.1 -0.6
Commuting to job workplace: Walk 1.4 1.5 3.4 0.0 -1.2 1.0 -1.8 -1.5 -1.4 0.7
Eye problems/disorders: Cataract 1.9 2.3 4.2 0.0 2.0 -1.9 2.0 0.6 0.8 -1.8
Mouth/teeth dental problems: Mouth ulcers 2.1 3.4 7.2 0.0 -1.9 1.7 -2.0 -2.2 -2.7 1.1
Medication for cholesterol 0.9 1.3 3.2 0.0 -0.7 1.6 -1.1 -1.0 -1.8 0.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.4 2.8 6.6 0.0 -1.8 1.8 -1.3 -2.6 -2.1 0.4
Back pain experienced in last month 1.0 1.5 2.8 0.0 1.1 -1.7 1.5 1.4 1.3 -0.8
Mineral and other dietary supplements 0.7 1.0 2.5 0.0 1.3 -0.9 0.4 -0.8 -1.0 -1.6
Breast cancer (self-reported) 0.2 0.2 0.9 0.0 -0.1 0.6 0.3 1.0 0.3 0.3
Asthma (self-reported) 1.9 3.9 9.8 0.0 2.2 -2.3 2.0 0.8 1.6 -3.1
Osteoporosis (self-reported) 0.5 0.6 1.6 0.0 -0.7 1.2 -0.7 -0.3 -0.9 0.9
Osteoarthritis (self-reported) 0.3 0.3 1.3 0.0 0.6 -0.6 1.1 0.3 0.1 -0.5
Medication: Aspirin 1.0 1.3 3.7 0.0 1.3 -1.7 0.6 -0.4 0.2 -1.9
Medication: Gliclazide 0.6 0.7 2.8 0.0 0.4 -0.4 0.5 -0.9 -0.8 -1.7
Illnesses of father: None of the above (group 1) 0.2 0.3 0.9 0.0 0.1 0.3 0.0 -0.4 -1.0 -1.0
Smoking status: Current 0.1 0.1 0.3 0.0 0.5 -0.3 -0.1 0.5 0.3 -0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 3.7 7.9 16.4 0.0 -2.8 2.6 -4.0 -4.0 -2.7 1.1
Whole body water mass 0.2 1.3 4.0 0.0 0.6 -0.8 2.0 1.1 0.7 -1.7
Leg predicted mass (right) 0.2 1.0 2.8 0.0 0.6 -0.6 1.6 0.8 0.4 -1.7
Arm fat mass (left) 0.4 1.5 7.1 0.0 1.2 -0.4 1.0 0.6 0.4 -2.7
Number of self-reported non-cancer illnesses 1.3 2.2 4.7 0.0 1.7 -2.0 1.8 0.4 0.8 -2.2
Average weekly champagne plus white wine intake 0.2 0.3 0.8 0.0 -0.7 -0.1 0.2 0.7 0.4 0.9
Miserableness 0.2 0.3 0.9 0.0 -0.2 0.1 -0.9 -1.0 -0.4 -0.3
Guilty feelings 1.1 1.7 6.4 0.0 -0.4 0.9 -0.9 -2.5 -1.9 0.1
Wears glasses or contact lenses 0.2 0.2 0.6 0.0 0.3 -0.2 0.8 0.4 -0.0 -0.6
Ever taken oral contraceptive pill 0.1 0.1 0.4 0.0 -0.4 -0.1 -0.5 -0.6 -0.4 0.1
Hearing aid user 0.3 0.3 0.8 0.0 -0.6 0.9 -0.4 -0.1 -0.3 0.9
Mother’s age at death 1.1 1.4 2.6 0.0 -0.9 1.4 -1.4 -0.9 -1.1 1.6
Financial situation satisfaction 0.3 0.4 1.5 0.0 0.0 0.4 -1.2 -0.6 -0.6 -0.5
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.5 0.0 0.7 0.1 0.1 0.3 -0.0 -0.6
Commuting to job workplace: Public transport 0.8 0.9 2.1 0.0 -0.3 1.2 -1.4 -1.3 -0.9 0.5
Eye problems/disorders: Glaucoma 0.1 0.2 0.5 0.0 0.1 0.3 0.1 -0.1 -0.7 -0.7
Medication: Blood pressure 0.2 0.3 0.9 0.0 0.1 -0.9 0.7 0.4 0.9 -0.0
Pain type(s) experienced in last month: Hip pain 1.9 2.3 4.7 0.0 1.9 -1.9 2.2 1.0 0.8 -1.7
Supplements: Fish oil (including cod liver oil) 1.2 1.5 3.7 0.0 -1.6 1.1 -1.1 0.9 1.0 1.9
High cholesterol (Self-reported) 0.6 1.0 3.4 0.0 1.2 -0.5 1.2 0.6 0.5 -1.8
Medication: Bendroflumethiazide 0.9 1.4 3.3 0.0 1.6 -1.1 1.8 0.5 0.7 -1.5
Medication: Paracetamol 0.2 0.3 1.0 0.0 0.3 0.1 -0.7 -1.0 0.1 -0.7
Medication: Lisinopril 0.2 0.3 1.4 0.0 -0.3 0.2 0.5 -0.4 -1.2 0.2
Medication: Atorvastatin 0.6 0.8 3.0 0.0 0.7 -1.0 0.8 0.2 0.4 -1.7
Illnesses of father: High blood pressure 2.3 2.9 5.9 0.0 1.9 -2.3 1.3 1.6 2.4 -1.0
Alcohol drinker status: Never 1.0 1.2 2.0 0.0 0.8 -1.3 1.4 1.4 0.6 -1.3
Ever smoked 0.7 1.2 3.3 0.0 -0.7 1.5 -1.8 -1.0 -1.1 0.6
Basal metabolic rate 0.3 1.6 4.5 0.0 0.8 -0.8 2.1 1.0 0.6 -2.1
Leg fat percentage (left) 0.3 1.1 5.3 0.0 1.1 0.1 0.6 0.6 0.4 -2.3
Arm fat-free mass (left) 0.3 1.7 4.3 0.0 0.8 -0.9 2.0 1.2 0.8 -2.1
Number of operations (self-reported) 0.7 1.0 2.9 0.0 -0.5 1.0 -1.0 -1.7 -1.2 -0.7
Average weekly beer plus cider intake 0.5 0.8 2.5 0.0 -0.4 0.8 -0.2 -1.6 -1.3 -0.8
Irritability 0.6 1.0 2.7 0.0 0.6 -0.4 -0.5 -1.6 -1.6 -1.1
Risk taking 0.1 0.2 0.5 0.0 0.0 -0.7 0.1 0.5 0.5 0.5
Ever had prostate specific antigen (PSA) test 3.1 3.6 10.8 0.0 -1.7 2.5 -3.3 -1.6 -1.0 1.1
Fractured/broken bones in last 5 years 0.1 0.2 0.7 0.0 0.1 0.2 0.8 0.6 0.2 0.0
Age started oral contraceptive pill 1.1 1.4 3.9 0.0 -1.2 1.3 -1.5 -0.4 -0.5 2.0
Diastolic blood pressure, automated reading 0.5 1.4 3.1 0.0 1.3 -1.2 1.5 0.9 0.9 -1.7
Ever depressed for a whole week 0.1 0.1 0.4 0.0 0.3 -0.3 0.3 -0.6 -0.5 -0.4
Unable to work because of sickness or disability 0.6 0.8 1.8 0.0 -1.1 1.3 -0.9 -0.1 -1.0 1.0
Commuting to job workplace: Cycle 0.9 1.0 2.9 0.0 -1.0 1.7 -1.1 -0.9 -0.8 0.8
Myopia 2.4 3.5 6.7 0.0 2.1 -2.0 1.9 2.6 2.0 -1.2
Vascular/heart problems diagnosed by doctor 1.2 3.3 7.7 0.0 -2.3 2.3 -2.1 -0.4 -0.7 2.8
Cholesterol lowering medication 0.6 0.9 1.9 0.0 0.8 -0.9 1.4 0.9 1.1 -1.1
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 1.4 0.0 -0.2 0.8 -0.2 -1.2 -1.0 -0.3
Pain experienced in last month 1.4 2.4 4.2 0.0 -1.5 2.1 -1.9 -1.5 -1.6 1.4
Supplements: Calcium 0.3 0.3 0.8 0.0 -0.1 -0.3 0.2 0.8 0.9 0.7
Basal cell carcinoma (self-reported) 0.3 0.4 1.4 0.0 -0.6 -0.0 0.0 1.2 0.6 0.9
Heart attack/myocardial infarction (self-reported) 0.4 0.5 1.3 0.0 -0.6 0.5 -0.7 -1.1 -0.8 0.5
Deep venous thrombosis (DVT) (self-reported) 0.2 0.2 1.0 0.0 -0.1 0.4 -0.1 -1.0 0.0 -0.5
Heart disease (siblings) 0.2 0.2 1.0 0.0 0.2 -0.0 0.1 -0.5 -0.3 -1.0
Alcohol drinker status: Previous 1.2 1.3 5.0 0.0 -0.3 -0.2 1.3 2.2 1.2 1.1
Pack years of smoking 0.4 0.5 1.6 0.0 0.2 -0.2 1.0 1.0 1.3 -0.0
Impedance of whole body 0.0 0.2 0.7 0.0 0.4 -0.2 0.8 -0.4 0.2 -0.6
Leg fat mass (left) 0.5 1.8 8.4 0.0 1.3 -0.4 1.2 0.7 0.5 -2.9
Arm predicted mass (left) 0.3 1.3 3.7 0.0 0.5 -0.5 1.8 1.1 0.7 -1.9