TWAS hub - GRB2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.1420	0.0517	0.0006	0.120	NA	0.084	NA	0.109	1.3e-09	NA	4.2e-07	NA	7.4e-09
2	NTR	Blood	0.0129	0.0071	0.0140	0.004	0.002	-0.001	0.002	0.002	1.8e-02	0.0800	6.1e-01	0.047	4.9e-02
3	TCGA	Breast Invasive Carcinoma	0.0171	0.0114	0.0030	0.001	0.009	0.004	NA	0.003	1.7e-01	0.0046	5.0e-02	NA	5.8e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Lung FVC	4.5	22.8	32.9	4.0	-4.4	5.7
Lupus	4.2	6.4	9.5	-2.6	1.7	-3.1
Ever had prostate specific antigen (PSA) test	4.2	4.9	11.6	0.8	-1.6	3.4
Comparative height size at age 10	3.9	21.2	37.6	-2.8	4.2	-6.1
Length of working week for main job	3.4	3.7	5.5	1.4	-2.3	1.9
Waist Hip Ratio (WHR)	3.1	14.1	20.2	-1.4	4.5	-4.5
Asthma	3.1	6.1	11.2	-3.4	1.8	-2.0
Chronotype (morning person)	3.0	6.9	12.8	-2.1	1.9	-3.6
Number of children fathered	3.0	3.3	3.4	-1.9	1.8	-1.8
Standing height	2.9	28.3	51.0	-3.2	4.9	-7.1
Financial situation satisfaction	2.9	3.6	6.7	2.0	-0.2	2.6
Alcohol drinker status: Previous	2.9	3.3	6.4	-2.5	0.7	-1.7
Pulse wave Arterial Stiffness index	2.8	3.3	6.9	-0.1	1.7	-2.6
Medication: Bendroflumethiazide	2.8	4.3	8.4	1.0	2.9	-1.8
Maternal smoking around birth	2.7	3.9	6.9	2.2	-0.1	2.6
Happiness	2.7	3.3	5.3	1.8	-1.2	2.3
Mouth/teeth dental problems: Loose teeth	2.7	3.2	4.8	2.0	-1.0	2.2
LDL Cholesterol	2.6	4.1	9.7	3.1	-0.3	1.6
Illness, injury, bereavement, stress in last 2 years	2.6	3.2	5.3	0.6	-2.3	2.0
Asthma (self-reported)	2.6	5.1	10.0	-3.2	1.6	-1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.6	5.6	7.9	2.1	-2.1	2.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.5	3.0	7.5	-2.7	0.8	-0.9
Alcohol intake frequency.	2.4	5.6	6.2	-2.3	2.3	-2.5
Diabetes (father)	2.3	2.8	3.2	-1.7	1.8	-1.5
Height	2.1	41.3	73.8	-4.2	5.7	-8.6
Smoking Status	2.1	5.0	8.3	1.2	-2.3	2.9
Allergy or Eczema	2.1	5.4	14.5	-0.3	-3.8	1.3
Respiratory disease	2.1	4.7	11.2	-3.3	1.1	-1.3
Past tobacco smoking	2.1	3.8	7.7	-1.2	1.6	-2.8
Loud music exposure frequency	2.1	2.3	4.6	-2.1	-1.3	0.8
Shortness of breath walking on level ground	2.1	2.5	3.7	-0.9	1.7	-1.9
Medication: Lisinopril	2.1	2.7	5.0	-1.7	0.5	-2.2
Mouth/teeth dental problems: Bleeding gums	2.0	2.5	4.0	-0.9	-2.0	1.7
Pulse wave peak to peak time	2.0	2.3	4.8	-0.0	-1.5	2.2
Bipolar Disorder (2018)	1.9	3.0	7.3	1.3	2.7	0.4
Fed-up feelings	1.9	3.5	4.7	2.1	-1.1	2.2
Age when periods started (menarche)	1.9	4.5	8.5	-0.4	-2.9	2.2
Wheeze or whistling in the chest in last year	1.9	3.4	7.9	-2.8	0.0	-1.5
Eye problems/disorders: None of the above	1.9	2.2	4.5	1.0	-1.1	2.1
Ever taken oral contraceptive pill	1.9	2.1	5.2	-0.6	-2.3	0.8
Medication: Lansoprazole	1.8	2.1	4.6	-2.1	0.3	-1.3
Birth weight	1.8	3.9	9.3	0.3	3.0	-1.5
Long-standing illness, disability or infirmity	1.8	2.8	5.0	-2.2	0.5	-1.8
Mean Putamen Volume	1.7	2.0	3.6	-1.9	-0.1	-1.5
Other serious medical condition/disability diagnosed by doctor	1.7	2.2	5.4	-2.3	-0.9	-0.8
HDL Cholesterol	1.6	2.7	8.2	-2.9	-0.2	-0.2
Lung FEV1/FVC ratio	1.6	8.2	14.5	3.8	-2.0	2.5
Hayfever, allergic rhinitis or eczema	1.6	3.4	8.4	0.6	-2.9	1.2
Diabetes (self-reported)	1.6	2.4	4.0	-2.0	-1.4	-1.2
Prospective memory result	1.6	2.0	3.8	-1.1	0.9	-1.9
Pulse wave reflection index	1.6	2.0	2.9	0.7	1.6	-1.7
Health satisfaction	1.6	2.0	3.7	1.2	1.9	-0.9
Age at last live birth	1.6	2.4	6.8	0.1	2.6	-0.6
Eye problems/disorders: Cataract	1.6	1.8	2.9	-0.3	1.6	-1.7
Eye problems/disorders: Diabetes related eye disease	1.5	1.6	3.9	-2.0	-0.6	-0.8
Qualifications: CSEs or equivalent	1.5	1.9	2.9	-1.0	1.4	-1.7
Hayfever/allergic rhinitis (self-reported)	1.5	2.0	5.0	-0.8	-2.2	0.7
Pulse rate	1.5	2.5	3.8	-1.9	-1.7	-1.0
Gout (self-reported)	1.5	2.0	4.5	-0.1	2.1	-1.2
Number of full sisters	1.5	1.9	4.5	1.0	2.1	-0.3
Osteoarthritis (self-reported)	1.5	1.9	3.2	0.2	1.8	-1.6
Tinnitus: Yes, now most or all of the time	1.5	1.8	3.6	1.9	1.2	0.6
Breast Cancer	1.4	3.5	8.8	-0.9	-3.0	0.9
High blood pressure	1.4	3.9	7.7	0.3	2.8	-2.0
Waist circumference	1.4	5.0	12.3	-0.5	3.5	-1.6
Alcohol usually taken with meals	1.4	2.3	4.5	-2.1	-1.4	-0.8
Mouth/teeth dental problems	1.4	2.2	3.2	-1.1	1.5	-1.8
Hair/balding pattern: Pattern 3	1.4	2.2	3.2	1.5	-1.8	1.1
Depression (self-reported)	1.4	1.7	2.7	-0.1	-1.5	1.6
Qualifications: O levels/GCSEs or equivalent	1.4	2.3	5.7	0.4	-2.4	1.0
Migraine (self-reported)	1.4	1.8	3.1	-1.1	1.0	-1.8
Hypertension (Self-reported)	1.4	3.9	7.7	0.5	2.8	-1.9
Ever smoked	1.4	2.4	5.8	0.5	-1.1	2.4
Trunk fat mass	1.3	5.4	14.1	-0.7	3.8	-1.2
Exposure to tobacco smoke outside home	1.3	1.7	2.8	-0.2	-1.5	1.7
Smoking status: Previous	1.3	2.0	3.7	0.8	-1.3	1.9
Commuting to job workplace: Public transport	1.3	1.6	2.7	1.7	0.2	1.4
Pain type(s) experienced in last month: Hip pain	1.3	1.6	4.1	-0.5	0.6	-2.0
Basal cell carcinoma (self-reported)	1.3	1.6	2.2	-1.3	-1.5	0.9
Ulcerative Colitis (UC)	1.2	2.2	4.7	-0.6	1.2	-2.2
Type 2 Diabetes (T2D) (2018)	1.2	2.3	5.1	-1.3	-0.5	-2.3
Tanning	1.2	14.3	22.9	0.8	-4.4	4.8
High blood pressure (mother)	1.2	1.7	2.7	-1.6	1.3	-0.9
Trunk fat-free mass	1.2	6.9	10.9	-1.8	2.5	-3.3
Trunk predicted mass	1.2	6.8	11.0	-1.8	2.5	-3.3
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	2.2	1.4	1.5	-0.0
Handedness (chirality/laterality): Left-handed	1.2	1.5	2.5	1.6	-1.3	0.5
Supplements: Fish oil (including cod liver oil)	1.2	1.6	2.5	-0.8	-1.6	1.4
Diastolic blood pressure, automated reading	1.2	3.8	7.7	1.9	2.8	-0.4
Verbal and Numeric Reasoning (VNR)	1.1	2.7	4.0	2.0	0.4	2.0
Alcohol intake versus 10 years previously	1.1	1.7	4.4	-0.4	2.1	-0.7
Illnesses of mother	1.1	1.3	3.0	0.9	0.5	-1.7
Hair/balding pattern: Pattern 4	1.1	2.6	5.1	-0.8	1.5	-2.3
Medication: Allopurinol	1.1	1.5	2.6	0.4	1.6	-1.3
Whole body fat mass	1.1	4.6	12.6	-0.4	3.6	-0.9
Commuting to job workplace: Car/motor vehicle	1.1	1.3	2.9	0.9	1.7	-0.3
Medication: Gliclazide	1.1	1.3	2.6	-0.8	0.8	-1.6
Mother’s age at death	1.1	1.4	1.6	1.3	-1.3	1.1
Alcohol drinker status: Never	1.1	1.3	2.1	-1.4	0.3	-1.3
Depression (Nagel 2018)	1.0	1.5	2.5	-0.2	1.6	-1.4
Worry (Nagel 2018)	1.0	2.1	3.7	0.3	1.6	-1.9
Hand grip strength (left)	1.0	2.7	4.7	-2.2	1.1	-1.5
Diabetes (mother)	1.0	1.2	2.2	-0.4	1.1	-1.5
Townsend deprivation index at recruitment	1.0	1.4	1.6	1.0	-1.2	1.3
Tense / ‘highly strung’	1.0	1.6	3.1	1.8	1.3	0.0
Heart disease (mother)	1.0	1.2	3.2	-1.8	-0.6	-0.3
Whole body fat-free mass	1.0	5.5	7.6	-1.6	2.5	-2.8
Whole body water mass	1.0	5.5	7.3	-1.6	2.5	-2.7
Basal metabolic rate	1.0	5.7	8.2	-1.5	2.9	-2.6
Arm predicted mass (left)	1.0	4.9	6.5	-1.5	2.5	-2.5
Bipolar Disorder or Schizophrenia	0.9	2.2	6.7	0.3	2.6	0.1
Coronary Artery Disease (CAD)	0.9	1.1	1.6	-1.0	-0.9	-1.3
Leg fat-free mass (left)	0.9	4.6	8.1	-1.0	2.8	-2.2
Trunk fat percentage	0.9	3.7	10.9	-0.1	3.3	-0.2
Supplements: Glucosamine	0.9	1.1	1.7	-1.3	-1.1	-0.7
Leg predicted mass (left)	0.9	4.6	8.1	-1.0	2.8	-2.2
Number of incorrect matches in round	0.9	1.6	4.1	-2.0	-0.1	-0.7
Weight	0.9	4.2	8.9	-1.0	3.0	-1.7
Noisy workplace	0.9	1.1	2.8	-1.7	-0.7	-0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.9	4.2	2.0	-1.6	1.4
Birth weight of first child	0.9	1.7	3.0	-0.9	1.2	-1.7
Medication: Paracetamol	0.9	1.5	2.6	1.6	1.3	0.3
Arm fat-free mass (right)	0.9	4.4	6.4	-1.4	2.5	-2.2
Leg fat mass (right)	0.9	3.3	9.5	-0.0	3.1	-0.7
Overall health rating	0.9	2.0	3.1	0.3	1.7	-1.8
Leg pain on walking	0.9	1.2	2.8	0.4	1.7	-0.7
Ever had bowel cancer screening	0.9	1.1	2.1	0.9	1.4	-0.6
Diabetes diagnosed by doctor	0.9	1.5	2.2	-1.5	-0.6	-1.4
Number of self-reported non-cancer illnesses	0.9	1.6	1.9	-1.4	1.1	-1.3
Arm fat-free mass (left)	0.9	4.8	6.9	-1.4	2.6	-2.4
Vascular/heart problems diagnosed by doctor	0.9	2.4	5.0	-0.5	-2.2	1.4
Supplements: Calcium	0.9	1.0	3.0	-1.7	-0.1	0.1
Heart attack/myocardial infarction (self-reported)	0.9	1.1	3.1	-0.4	-1.8	-0.2
Depressed Affect (Nagel 2018)	0.8	1.6	2.5	1.4	-0.6	1.6
Blood White Count	0.8	5.9	10.1	0.6	3.2	-2.7
Number of treatments/medications taken	0.8	1.4	2.5	-0.6	1.2	-1.6
Ever used hormone-replacement therapy (HRT)	0.8	1.0	1.6	0.8	-1.3	0.9
Vitamin and mineral supplements	0.8	1.1	2.7	0.7	-0.4	1.6
Pack years adult smoking proportion	0.8	1.3	2.2	-1.5	0.4	-1.2
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	2.0	0.1	-0.9	1.4
Serious illness, injury or assault to yourself	0.8	1.0	2.0	-0.8	0.3	-1.4
Multivitamins +/- minerals	0.8	1.0	1.7	-1.1	0.1	-1.3
Falls in the last year	0.8	1.1	1.9	-0.8	-1.4	-0.8
Forced expiratory volume in 1-second (FEV1)	0.8	2.8	4.1	2.0	-1.3	1.6
Lung cancer (father)	0.8	1.0	2.2	-0.7	0.5	-1.5
Chronic bronchitis/emphysema (mother)	0.8	0.9	1.8	-0.2	-1.0	1.3
High blood pressure (siblings)	0.8	1.2	2.0	1.2	0.5	1.4
Medication: Omeprazole	0.8	0.9	1.7	-0.1	1.0	-1.3
Arm predicted mass (right)	0.8	4.3	5.9	-1.4	2.4	-2.3
Family relationship satisfaction	0.8	1.0	2.0	0.9	-0.4	1.4
Supplements: Vitamin C	0.8	1.0	2.2	-0.8	0.2	-1.5
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	4.1	-0.7	0.7	-2.0
Back pain experienced in last month	0.8	1.1	2.4	-1.5	0.5	-0.9
Breast cancer (self-reported)	0.8	0.9	2.2	-1.5	0.5	-0.6
Average weekly beer plus cider intake	0.8	1.2	1.9	1.2	1.4	-0.5
Risk taking	0.8	1.1	3.2	-1.8	-0.5	-0.1
Cholesterol lowering medication	0.8	1.2	2.2	-1.0	0.6	-1.5
Reaction Time	0.7	1.3	3.6	0.2	-0.5	1.9
Cardiovascular Disease	0.7	2.4	5.0	0.4	2.2	-1.4
Systolic blood pressure, automated reading	0.7	2.0	5.8	0.5	2.4	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	3.1	-1.8	0.1	-0.5
Had other major operations	0.7	0.8	1.8	0.7	1.3	0.5
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	2.4	-1.5	-0.4	-0.2
Heart attack	0.7	0.8	2.2	-0.5	-1.5	-0.1
Fluid intelligence score	0.7	1.5	2.6	1.0	-1.0	1.6
Time employed in main current job	0.7	0.8	1.9	1.4	0.6	0.4
Father’s age at death	0.7	0.9	1.5	-0.6	-1.2	1.0
Number of live births	0.7	0.9	2.2	0.6	1.5	-0.4
Body fat percentage	0.7	2.7	8.0	0.1	2.8	0.1
Number of full brothers	0.7	0.9	1.6	1.3	1.0	0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	2.1	1.4	0.0	0.5
Friendships satisfaction	0.7	0.8	2.3	0.3	-0.2	1.5
Miserableness	0.7	1.1	1.6	0.4	-1.3	1.3
Age started oral contraceptive pill	0.7	0.9	2.1	-0.2	-1.4	0.7
Pain experienced in last month	0.7	1.1	2.5	1.6	-0.2	0.9
Leg fat mass (left)	0.7	2.6	7.8	-0.0	2.8	-0.3
Intelligence (Savage-Jansen 2018)	0.6	1.9	3.0	1.7	0.1	1.6
Schizophrenia vs Biploar Disorder	0.6	0.8	1.4	-0.8	-1.2	-0.4
Alzheimer’s Disease (in mother)	0.6	0.8	1.7	0.2	-0.7	1.3
Alzheimer’s Disease (including proxy)	0.6	0.9	2.1	0.7	-0.3	1.4
Irritable Bowel Disease (IBD)	0.6	1.3	3.5	-0.5	0.4	-1.9
Ovarian Cancer	0.6	0.8	1.2	0.9	-0.6	1.1
Prostate Cancer	0.6	0.9	1.5	0.3	-1.2	1.0
Body Mass Index (BMI) (2010)	0.6	0.8	1.5	-0.0	1.2	-1.0
HbA1C	0.6	0.7	1.3	-0.4	-0.9	-1.1
Schizophrenia (2014)	0.6	1.4	3.8	-0.6	2.0	0.0
Ever had hysterectomy (womb removed)	0.6	0.7	1.4	-0.6	-1.2	0.6
Severe depression (siblings)	0.6	0.6	1.3	-0.1	-1.1	0.7
Hearing difficulty/problems with background noise	0.6	0.9	2.1	0.8	1.4	0.0
Hair/balding pattern: Pattern 2	0.6	0.8	2.3	0.1	1.5	-0.1
Qualifications: None of the above	0.6	1.2	2.6	0.7	1.6	0.7
Medication: Ramipril	0.6	0.7	1.1	0.4	-0.9	1.1
Medication: Simvastatin	0.6	0.8	2.0	0.3	0.7	-1.4
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	2.6	-0.1	-0.6	1.6
Medication: Blood pressure	0.6	1.1	2.1	-0.0	1.1	-1.4
Illnesses of father: Heart disease	0.6	0.8	2.2	-0.3	-1.5	-0.4
Leg fat-free mass (right)	0.6	3.2	5.2	-1.1	2.3	-1.8
Leg predicted mass (right)	0.6	3.1	4.9	-1.2	2.2	-1.8
Arm fat mass (left)	0.6	2.5	7.3	0.4	2.7	0.1
Medication: Paracetamol	0.6	1.0	1.9	1.4	1.0	0.3
Illnesses of father: High blood pressure	0.6	0.7	1.3	-0.6	0.8	1.1
Ever depressed for a whole week	0.6	0.7	1.3	-0.8	-0.4	-1.1
Alzheimer’s Disease (in father)	0.5	0.5	0.8	0.8	0.3	0.9
Primary Biliary Cirrhosis	0.5	0.7	1.9	1.4	0.5	-0.3
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.0	-1.0	0.5	-0.8
Ulcerative Colitis	0.5	0.7	1.5	-0.7	0.4	-1.2
Blood Red Count	0.5	4.6	10.2	0.3	3.2	-1.9
Heel T-Score	0.5	4.2	6.9	2.4	0.3	2.6
Hair Pigment	0.5	15.3	28.0	-2.6	3.3	-5.3
Medication for hormone replacement therapy	0.5	0.5	0.9	-0.9	0.1	-0.9
Impedance of leg (right)	0.5	2.5	5.1	-0.3	1.5	-2.2
Taking other prescription medications	0.5	0.8	1.7	-0.4	-0.7	-1.3
Arm fat percentage (right)	0.5	2.0	4.9	0.8	2.2	0.7
Mouth/teeth dental problems: Dentures	0.5	0.8	1.3	1.1	1.1	-0.1
Arm fat mass (right)	0.5	2.3	6.8	0.0	2.6	-0.1
Medication: Ventolin 100micrograms inhaler	0.5	0.7	1.1	-0.8	0.6	-1.1
Leg fat percentage (right)	0.5	1.7	5.2	-0.0	2.3	-0.0
Neck or shoulder pain in last month	0.5	0.7	1.3	-0.7	0.5	-1.1
Had major operations	0.5	0.6	0.9	0.9	-0.9	0.2
Arm fat percentage (left)	0.5	1.8	4.0	0.8	2.0	0.9
Commuting to job workplace: Walk	0.5	0.6	0.9	-0.1	-0.9	0.9
Mouth/teeth dental problems: Mouth ulcers	0.5	0.7	2.1	0.2	-1.5	0.2
Illnesses of father: None of the above (group 1)	0.5	0.6	0.7	0.8	0.7	-0.8
Unable to work because of sickness or disability	0.5	0.7	1.0	0.7	-0.8	1.0
Commuting to job workplace: Cycle	0.5	0.6	1.3	-1.1	-0.5	-0.6
Pack years of smoking	0.5	0.7	1.0	-1.0	0.3	-1.0
Age at First Birth	0.4	0.6	1.6	-0.2	0.2	1.3
Neuroticism (2016)	0.4	0.5	0.9	1.0	0.7	0.2
Rheumatoid Arthritis	0.4	0.6	1.0	-1.0	-0.8	-0.3
Triglycerides	0.4	0.6	1.2	0.4	1.1	-0.7
Supplements: Zinc	0.4	0.5	0.7	-0.8	-0.1	-0.8
Relative age voice broke	0.4	0.6	1.4	0.6	-1.2	0.4
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	1.2	0.4	1.1	0.3
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.0	-0.6	-1.0	0.1
Chronic bronchitis/emphysema (father)	0.4	0.5	0.8	0.4	0.9	0.6
Had menopause	0.4	0.5	1.0	1.0	-0.3	0.6
Financial difficulties in last 2 years	0.4	0.5	1.3	-1.1	0.5	-0.3
Pain all over the body in last month	0.4	0.4	1.0	-1.0	-0.5	0.2
Impedance of arm (right)	0.4	1.9	3.4	0.2	1.5	-1.8
Worrier / anxious feelings	0.4	0.8	2.2	-0.2	0.2	-1.5
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.1	-0.5	0.6	-1.1
Breastfed as a baby	0.4	0.5	0.9	0.7	0.9	-0.3
Glaucoma (self-reported)	0.4	0.5	1.0	0.0	1.0	-0.7
Medication: Amlodipine	0.4	0.6	0.9	0.7	-0.8	0.9
Forced vital capacity (FVC), Best measure	0.4	1.3	1.6	1.3	-1.2	0.9
Qualifications: College or University degree	0.4	1.3	2.9	1.7	0.9	0.3
Emphysema/chronic bronchitis	0.4	0.5	0.8	-0.2	0.7	-0.9
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	0.9	-0.8	-1.0	-0.2
Illnesses of siblings: Diabetes	0.4	0.5	1.0	-1.0	0.2	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.5	-0.1	-0.1	-1.2
Mineral and other dietary supplements	0.4	0.6	1.5	1.2	0.5	0.1
Smoking status: Current	0.4	0.7	1.7	0.5	-0.3	1.3
Average weekly champagne plus white wine intake	0.4	0.5	0.9	-0.8	-0.9	-0.1
Wears glasses or contact lenses	0.4	0.5	0.9	-0.4	0.7	-0.9
Hearing aid user	0.4	0.5	0.9	-0.4	-0.9	0.6
Leg fat percentage (left)	0.4	1.3	3.6	0.2	1.9	0.6
Number of operations (self-reported)	0.4	0.5	1.4	1.2	-0.1	0.4
Schizophrenia (2018)	0.3	0.6	1.2	-0.7	1.1	-0.2
Crohns Disease (2017)	0.3	0.6	1.7	-0.4	-0.1	-1.3
Major Depression (MDD)	0.3	0.3	0.7	-0.1	0.9	-0.4
Fasting Glucose	0.3	0.4	1.0	-0.3	-0.4	1.0
Hearing difficulty/problems: Yes	0.3	0.4	0.9	0.4	1.0	0.2
Stomach or abdominal pain in last month	0.3	0.4	0.7	0.3	0.5	-0.9
Body mass index (BMI)	0.3	1.1	2.2	0.4	1.0	1.5
Nervous feelings	0.3	0.6	1.6	0.1	0.4	-1.3
Forced vital capacity (FVC)	0.3	1.2	1.7	1.3	-0.8	1.1
Allergy	0.3	0.7	1.5	0.8	1.2	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.0	0.2	-1.0	-0.2
Blood clot in the leg (DVT)	0.3	0.3	0.7	-0.2	0.9	-0.5
Comparative body size at age 10	0.3	0.7	2.2	-1.5	0.1	-0.2
Worry too long after embarrassment	0.3	0.5	1.3	1.1	-0.2	-0.3
Medication: Ibuprofen	0.3	0.4	0.6	0.8	-0.5	0.5
Medication: Seretide 50 evohaler	0.3	0.4	0.6	-0.1	0.8	0.7
Mean time to correctly identify matches	0.3	0.6	1.4	0.1	0.6	1.2
Suffer from ‘nerves’	0.3	0.5	1.3	1.1	0.5	-0.2
Medication: Aspirin	0.3	0.4	0.8	-0.5	-0.9	-0.1
Loneliness, isolation	0.3	0.4	0.8	0.9	0.0	0.5
High cholesterol (Self-reported)	0.3	0.6	1.2	-0.1	1.1	-0.7
Medication: Atorvastatin	0.3	0.4	1.3	-1.1	-0.0	-0.2
Myopia	0.3	0.5	1.0	-0.6	1.0	0.1
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.7	0.3	0.5	-0.8
Impedance of whole body	0.3	1.4	2.6	-0.2	1.3	-1.6
Neuroticism (Nagel 2018)	0.2	0.6	1.4	1.2	0.5	-0.2
Bipolar Disorder (2011)	0.2	0.2	0.6	0.0	0.0	-0.7
Blood Eosinophil Count	0.2	1.9	4.7	-0.6	0.8	-2.2
BMI	0.2	1.2	1.7	1.0	0.9	1.3
Systolic Blood Pressure	0.2	0.9	2.6	0.0	1.6	-0.0
Average weekly spirits intake	0.2	0.2	0.5	-0.0	-0.2	0.7
Hand grip strength (right)	0.2	0.7	1.2	-1.1	0.7	-0.6
Current tobacco smoking	0.2	0.3	0.7	0.3	0.1	0.8
Average weekly fortified wine intake	0.2	0.3	0.6	0.4	0.8	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.5	-0.2	0.4	-0.7
Impedance of leg (left)	0.2	1.0	2.2	-0.3	0.8	-1.5
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.3	0.4	1.1	-0.4
Illnesses of siblings	0.2	0.2	0.7	0.1	-0.0	-0.8
Neuroticism score	0.2	0.4	0.8	0.9	-0.6	0.3
Impedance of arm (left)	0.2	1.1	1.7	0.3	1.2	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.2	0.6	0.3	-0.8	0.3
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.7	-0.1	-0.9	0.1
Headache pain in last month	0.2	0.3	0.7	0.8	0.4	0.2
Age at first live birth	0.2	0.4	1.0	0.4	1.0	-0.2
Medication for pain relief, constipation, heartburn	0.2	0.4	0.9	-1.0	0.6	0.1
Pulse rate, automated reading	0.2	0.8	1.9	0.1	-1.4	-0.7
Chest pain or discomfort	0.2	0.3	0.4	0.0	-0.7	-0.6
Knee pain experienced in last month	0.2	0.3	0.8	-0.1	-0.2	-0.9
Average weekly red wine intake	0.2	0.3	0.7	-0.4	0.9	-0.1
Mood swings	0.2	0.3	0.5	0.1	-0.7	0.7
Qualifications: nursing, teaching	0.2	0.3	0.9	-0.2	1.0	0.1
Medication for cholesterol	0.2	0.2	0.4	0.7	-0.4	0.3
Guilty feelings	0.2	0.3	0.5	0.4	-0.4	-0.7
Eye problems/disorders: Glaucoma	0.2	0.2	0.7	0.8	0.2	-0.1
Medication: Blood pressure	0.2	0.5	0.7	-0.1	0.8	-0.8
Fractured/broken bones in last 5 years	0.2	0.2	0.4	-0.3	0.4	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.6	0.2	0.8	-0.4
Heart disease (siblings)	0.2	0.3	0.5	-0.5	0.4	-0.7
Crohns Disease (2012)	0.1	0.1	0.2	0.5	-0.1	0.2
Neuroticism	0.1	0.2	0.3	0.4	-0.6	0.0
Relative age of first facial hair	0.1	0.2	0.3	-0.6	-0.3	-0.4
Angina	0.1	0.1	0.2	-0.5	-0.0	-0.2
Medication: Metformin	0.1	0.1	0.3	-0.2	-0.5	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.4	0.6	0.6	0.3
Medication: Atenolol	0.1	0.1	0.3	0.5	-0.2	-0.0
Sitting height	0.1	0.6	1.0	-0.8	0.1	-1.0
Hip circumference	0.1	0.5	1.4	0.2	1.2	0.1
Medication: Cholesterol lowering	0.1	0.1	0.2	-0.3	-0.3	-0.5
Exposure to tobacco smoke at home	0.1	0.2	0.5	-0.7	0.1	0.0
Peak expiratory flow (PEF)	0.1	0.2	0.5	-0.1	-0.5	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.3	-0.4	-0.6	0.3
Angina (self-reported)	0.1	0.2	0.5	-0.7	0.1	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.2	-0.5	-0.1	0.3
Osteoporosis (self-reported)	0.1	0.1	0.3	0.5	0.1	0.0
Medication: Aspirin	0.1	0.1	0.4	-0.1	-0.6	0.1
Irritability	0.1	0.2	0.4	0.7	0.1	0.3
Blood Platelet Count	0.0	0.1	0.3	-0.1	0.5	-0.0
Hypothyroidism (self reported)	0.0	0.0	0.1	0.0	0.3	0.0
Sensitivity / hurt feelings	0.0	0.0	0.0	0.1	0.1	-0.1
Frequency of depressed mood in last 2 weeks	0.0	0.0	0.0	-0.1	0.2	-0.2
Medication: Co-codamol	0.0	0.0	0.1	-0.3	0.0	-0.1
Medication: Levothyroxine sodium	0.0	0.0	0.1	0.0	-0.2	-0.3
Qualifications: A levels/AS levels or equivalent	0.0	0.1	0.2	0.2	-0.1	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.0	0.0	0.1	-0.1	0.0
Hypothyroidism/myxoedema (self-reported)	0.0	0.0	0.1	-0.1	0.3	0.0

Hub : Genes

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Trait associations