Hub : Genes

GRB2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.1420	0.0517	0.0006	0.120	NA	0.084	NA	0.109	1.3e-09	NA	4.2e-07	NA	7.4e-09
2	NTR	Blood	0.0129	0.0071	0.0140	0.004	0.002	-0.001	0.002	0.002	1.8e-02	0.0800	6.1e-01	0.047	4.9e-02
3	TCGA	Breast Invasive Carcinoma	0.0171	0.0114	0.0030	0.001	0.009	0.004	NA	0.003	1.7e-01	0.0046	5.0e-02	NA	5.8e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	1.9	3.0	7.3	1.3	2.7	0.4
Bipolar Disorder or Schizophrenia	0.9	2.2	6.7	0.3	2.6	0.1
Depressed Affect (Nagel 2018)	0.8	1.6	2.5	1.4	-0.6	1.6
Depression (Nagel 2018)	1.0	1.5	2.5	-0.2	1.6	-1.4
Intelligence (Savage-Jansen 2018)	0.6	1.9	3.0	1.7	0.1	1.6
Neuroticism (Nagel 2018)	0.2	0.6	1.4	1.2	0.5	-0.2
Schizophrenia (2018)	0.3	0.6	1.2	-0.7	1.1	-0.2
Schizophrenia vs Biploar Disorder	0.6	0.8	1.4	-0.8	-1.2	-0.4
Worry (Nagel 2018)	1.0	2.1	3.7	0.3	1.6	-1.9
Alzheimer’s Disease (in mother)	0.6	0.8	1.7	0.2	-0.7	1.3
Alzheimer’s Disease (in father)	0.5	0.5	0.8	0.8	0.3	0.9
Alzheimer’s Disease (including proxy)	0.6	0.9	2.1	0.7	-0.3	1.4
Crohns Disease (2017)	0.3	0.6	1.7	-0.4	-0.1	-1.3
Irritable Bowel Disease (IBD)	0.6	1.3	3.5	-0.5	0.4	-1.9
Ulcerative Colitis (UC)	1.2	2.2	4.7	-0.6	1.2	-2.2
Major Depression (MDD)	0.3	0.3	0.7	-0.1	0.9	-0.4
Reaction Time	0.7	1.3	3.6	0.2	-0.5	1.9
Verbal and Numeric Reasoning (VNR)	1.1	2.7	4.0	2.0	0.4	2.0
Breast Cancer	1.4	3.5	8.8	-0.9	-3.0	0.9
Ovarian Cancer	0.6	0.8	1.2	0.9	-0.6	1.1
Prostate Cancer	0.6	0.9	1.5	0.3	-1.2	1.0
Age at First Birth	0.4	0.6	1.6	-0.2	0.2	1.3
Bipolar Disorder (2011)	0.2	0.2	0.6	0.0	0.0	-0.7
Body Mass Index (BMI) (2010)	0.6	0.8	1.5	-0.0	1.2	-1.0
Coronary Artery Disease (CAD)	0.9	1.1	1.6	-1.0	-0.9	-1.3
Crohns Disease (2012)	0.1	0.1	0.2	0.5	-0.1	0.2
Mean Putamen Volume	1.7	2.0	3.6	-1.9	-0.1	-1.5
Fasting Glucose	0.3	0.4	1.0	-0.3	-0.4	1.0
HbA1C	0.6	0.7	1.3	-0.4	-0.9	-1.1
HDL Cholesterol	1.6	2.7	8.2	-2.9	-0.2	-0.2
LDL Cholesterol	2.6	4.1	9.7	3.1	-0.3	1.6
Lupus	4.2	6.4	9.5	-2.6	1.7	-3.1
Neuroticism (2016)	0.4	0.5	0.9	1.0	0.7	0.2
Primary Biliary Cirrhosis	0.5	0.7	1.9	1.4	0.5	-0.3
Rheumatoid Arthritis	0.4	0.6	1.0	-1.0	-0.8	-0.3
Schizophrenia (2014)	0.6	1.4	3.8	-0.6	2.0	0.0
Triglycerides	0.4	0.6	1.2	0.4	1.1	-0.7
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.0	-1.0	0.5	-0.8
Ulcerative Colitis	0.5	0.7	1.5	-0.7	0.4	-1.2
Blood Eosinophil Count	0.2	1.9	4.7	-0.6	0.8	-2.2
Blood Platelet Count	0.0	0.1	0.3	-0.1	0.5	-0.0
Blood Red Count	0.5	4.6	10.2	0.3	3.2	-1.9
Blood White Count	0.8	5.9	10.1	0.6	3.2	-2.7
Heel T-Score	0.5	4.2	6.9	2.4	0.3	2.6
BMI	0.2	1.2	1.7	1.0	0.9	1.3
Height	2.1	41.3	73.8	-4.2	5.7	-8.6
Waist Hip Ratio (WHR)	3.1	14.1	20.2	-1.4	4.5	-4.5
Systolic Blood Pressure	0.2	0.9	2.6	0.0	1.6	-0.0
Smoking Status	2.1	5.0	8.3	1.2	-2.3	2.9
Allergy or Eczema	2.1	5.4	14.5	-0.3	-3.8	1.3
Cardiovascular Disease	0.7	2.4	5.0	0.4	2.2	-1.4
Hypothyroidism (self reported)	0.0	0.0	0.1	0.0	0.3	0.0
Respiratory disease	2.1	4.7	11.2	-3.3	1.1	-1.3
Type 2 Diabetes (T2D) (2018)	1.2	2.3	5.1	-1.3	-0.5	-2.3
Lung FEV1/FVC ratio	1.6	8.2	14.5	3.8	-2.0	2.5
Lung FVC	4.5	22.8	32.9	4.0	-4.4	5.7
Neuroticism	0.1	0.2	0.3	0.4	-0.6	0.0
Chronotype (morning person)	3.0	6.9	12.8	-2.1	1.9	-3.6
Hair Pigment	0.5	15.3	28.0	-2.6	3.3	-5.3
Tanning	1.2	14.3	22.9	0.8	-4.4	4.8
Hand grip strength (left)	1.0	2.7	4.7	-2.2	1.1	-1.5
Number of treatments/medications taken	0.8	1.4	2.5	-0.6	1.2	-1.6
Average weekly spirits intake	0.2	0.2	0.5	-0.0	-0.2	0.7
Sensitivity / hurt feelings	0.0	0.0	0.0	0.1	0.1	-0.1
Frequency of depressed mood in last 2 weeks	0.0	0.0	0.0	-0.1	0.2	-0.2
Hearing difficulty/problems: Yes	0.3	0.4	0.9	0.4	1.0	0.2
Relative age of first facial hair	0.1	0.2	0.3	-0.6	-0.3	-0.4
Other serious medical condition/disability diagnosed by doctor	1.7	2.2	5.4	-2.3	-0.9	-0.8
Ever used hormone-replacement therapy (HRT)	0.8	1.0	1.6	0.8	-1.3	0.9
Ever had hysterectomy (womb removed)	0.6	0.7	1.4	-0.6	-1.2	0.6
Systolic blood pressure, automated reading	0.7	2.0	5.8	0.5	2.4	0.1
Eye problems/disorders: Diabetes related eye disease	1.5	1.6	3.9	-2.0	-0.6	-0.8
Angina	0.1	0.1	0.2	-0.5	-0.0	-0.2
Medication for hormone replacement therapy	0.5	0.5	0.9	-0.9	0.1	-0.9
Vitamin and mineral supplements	0.8	1.1	2.7	0.7	-0.4	1.6
Supplements: Zinc	0.4	0.5	0.7	-0.8	-0.1	-0.8
Medication: Co-codamol	0.0	0.0	0.1	-0.3	0.0	-0.1
Medication: Metformin	0.1	0.1	0.3	-0.2	-0.5	-0.1
Diabetes (father)	2.3	2.8	3.2	-1.7	1.8	-1.5
Diabetes (mother)	1.0	1.2	2.2	-0.4	1.1	-1.5
Severe depression (siblings)	0.6	0.6	1.3	-0.1	-1.1	0.7
Pack years adult smoking proportion	0.8	1.3	2.2	-1.5	0.4	-1.2
Impedance of leg (right)	0.5	2.5	5.1	-0.3	1.5	-2.2
Leg fat-free mass (left)	0.9	4.6	8.1	-1.0	2.8	-2.2
Trunk fat percentage	0.9	3.7	10.9	-0.1	3.3	-0.2
Hand grip strength (right)	0.2	0.7	1.2	-1.1	0.7	-0.6
Townsend deprivation index at recruitment	1.0	1.4	1.6	1.0	-1.2	1.3
Current tobacco smoking	0.2	0.3	0.7	0.3	0.1	0.8
Average weekly fortified wine intake	0.2	0.3	0.6	0.4	0.8	-0.1
Maternal smoking around birth	2.7	3.9	6.9	2.2	-0.1	2.6
Fed-up feelings	1.9	3.5	4.7	2.1	-1.1	2.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.5	-0.2	0.4	-0.7
Relative age voice broke	0.4	0.6	1.4	0.6	-1.2	0.4
Taking other prescription medications	0.5	0.8	1.7	-0.4	-0.7	-1.3
Age when periods started (menarche)	1.9	4.5	8.5	-0.4	-2.9	2.2
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	2.0	0.1	-0.9	1.4
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.4	0.6	0.6	0.3
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	1.2	0.4	1.1	0.3
Qualifications: CSEs or equivalent	1.5	1.9	2.9	-1.0	1.4	-1.7
Serious illness, injury or assault to yourself	0.8	1.0	2.0	-0.8	0.3	-1.4
High blood pressure	1.4	3.9	7.7	0.3	2.8	-2.0
Hayfever, allergic rhinitis or eczema	1.6	3.4	8.4	0.6	-2.9	1.2
Multivitamins +/- minerals	0.8	1.0	1.7	-1.1	0.1	-1.3
Stomach or abdominal pain in last month	0.3	0.4	0.7	0.3	0.5	-0.9
Supplements: Glucosamine	0.9	1.1	1.7	-1.3	-1.1	-0.7
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.0	-0.6	-1.0	0.1
Medication: Atenolol	0.1	0.1	0.3	0.5	-0.2	-0.0
Medication: Levothyroxine sodium	0.0	0.0	0.1	0.0	-0.2	-0.3
Sitting height	0.1	0.6	1.0	-0.8	0.1	-1.0
Chronic bronchitis/emphysema (father)	0.4	0.5	0.8	0.4	0.9	0.6
High blood pressure (mother)	1.2	1.7	2.7	-1.6	1.3	-0.9
Body mass index (BMI)	0.3	1.1	2.2	0.4	1.0	1.5
Impedance of leg (left)	0.2	1.0	2.2	-0.3	0.8	-1.5
Leg predicted mass (left)	0.9	4.6	8.1	-1.0	2.8	-2.2
Trunk fat mass	1.3	5.4	14.1	-0.7	3.8	-1.2
Waist circumference	1.4	5.0	12.3	-0.5	3.5	-1.6
Number of incorrect matches in round	0.9	1.6	4.1	-2.0	-0.1	-0.7
Past tobacco smoking	2.1	3.8	7.7	-1.2	1.6	-2.8
Alcohol usually taken with meals	1.4	2.3	4.5	-2.1	-1.4	-0.8
Nervous feelings	0.3	0.6	1.6	0.1	0.4	-1.3
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	3.1	-1.8	0.1	-0.5
Hearing difficulty/problems with background noise	0.6	0.9	2.1	0.8	1.4	0.0
Hair/balding pattern: Pattern 2	0.6	0.8	2.3	0.1	1.5	-0.1
Had menopause	0.4	0.5	1.0	1.0	-0.3	0.6
Had other major operations	0.7	0.8	1.8	0.7	1.3	0.5
Forced vital capacity (FVC)	0.3	1.2	1.7	1.3	-0.8	1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.3	0.4	1.1	-0.4
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	2.4	-1.5	-0.4	-0.2
Qualifications: None of the above	0.6	1.2	2.6	0.7	1.6	0.7
Financial difficulties in last 2 years	0.4	0.5	1.3	-1.1	0.5	-0.3
Mouth/teeth dental problems	1.4	2.2	3.2	-1.1	1.5	-1.8
Heart attack	0.7	0.8	2.2	-0.5	-1.5	-0.1
Allergy	0.3	0.7	1.5	0.8	1.2	-0.1
Pain all over the body in last month	0.4	0.4	1.0	-1.0	-0.5	0.2
Diabetes (self-reported)	1.6	2.4	4.0	-2.0	-1.4	-1.2
Hayfever/allergic rhinitis (self-reported)	1.5	2.0	5.0	-0.8	-2.2	0.7
Medication: Ramipril	0.6	0.7	1.1	0.4	-0.9	1.1
Medication: Simvastatin	0.6	0.8	2.0	0.3	0.7	-1.4
Fluid intelligence score	0.7	1.5	2.6	1.0	-1.0	1.6
Illnesses of siblings	0.2	0.2	0.7	0.1	-0.0	-0.8
Neuroticism score	0.2	0.4	0.8	0.9	-0.6	0.3
Weight	0.9	4.2	8.9	-1.0	3.0	-1.7
Impedance of arm (right)	0.4	1.9	3.4	0.2	1.5	-1.8
Arm fat percentage (right)	0.5	2.0	4.9	0.8	2.2	0.7
Trunk fat-free mass	1.2	6.9	10.9	-1.8	2.5	-3.3
Hip circumference	0.1	0.5	1.4	0.2	1.2	0.1
Time employed in main current job	0.7	0.8	1.9	1.4	0.6	0.4
Alcohol intake versus 10 years previously	1.1	1.7	4.4	-0.4	2.1	-0.7
Father’s age at death	0.7	0.9	1.5	-0.6	-1.2	1.0
Worrier / anxious feelings	0.4	0.8	2.2	-0.2	0.2	-1.5
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.1	-0.5	0.6	-1.1
Falls in the last year	0.8	1.1	1.9	-0.8	-1.4	-0.8
Hair/balding pattern: Pattern 3	1.4	2.2	3.2	1.5	-1.8	1.1
Number of live births	0.7	0.9	2.2	0.6	1.5	-0.4
Forced expiratory volume in 1-second (FEV1)	0.8	2.8	4.1	2.0	-1.3	1.6
Pulse rate	1.5	2.5	3.8	-1.9	-1.7	-1.0
Happiness	2.7	3.3	5.3	1.8	-1.2	2.3
Noisy workplace	0.9	1.1	2.8	-1.7	-0.7	-0.0
Qualifications: A levels/AS levels or equivalent	0.0	0.1	0.2	0.2	-0.1	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.0	0.0	0.1	-0.1	0.0
Mouth/teeth dental problems: Dentures	0.5	0.8	1.3	1.1	1.1	-0.1
Asthma	3.1	6.1	11.2	-3.4	1.8	-2.0
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.0	0.2	-1.0	-0.2
Medication: Cholesterol lowering	0.1	0.1	0.2	-0.3	-0.3	-0.5
Depression (self-reported)	1.4	1.7	2.7	-0.1	-1.5	1.6
Medication: Lansoprazole	1.8	2.1	4.6	-2.1	0.3	-1.3
Prospective memory result	1.6	2.0	3.8	-1.1	0.9	-1.9
Lung cancer (father)	0.8	1.0	2.2	-0.7	0.5	-1.5
Illnesses of mother	1.1	1.3	3.0	0.9	0.5	-1.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.9	4.2	2.0	-1.6	1.4
Pulse wave Arterial Stiffness index	2.8	3.3	6.9	-0.1	1.7	-2.6
Impedance of arm (left)	0.2	1.1	1.7	0.3	1.2	-1.3
Arm fat mass (right)	0.5	2.3	6.8	0.0	2.6	-0.1
Trunk predicted mass	1.2	6.8	11.0	-1.8	2.5	-3.3
Standing height	2.9	28.3	51.0	-3.2	4.9	-7.1
Length of working week for main job	3.4	3.7	5.5	1.4	-2.3	1.9
Exposure to tobacco smoke at home	0.1	0.2	0.5	-0.7	0.1	0.0
Breastfed as a baby	0.4	0.5	0.9	0.7	0.9	-0.3
Tense / ‘highly strung’	1.0	1.6	3.1	1.8	1.3	0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.2	0.6	0.3	-0.8	0.3
Hair/balding pattern: Pattern 4	1.1	2.6	5.1	-0.8	1.5	-2.3
Birth weight of first child	0.9	1.7	3.0	-0.9	1.2	-1.7
Peak expiratory flow (PEF)	0.1	0.2	0.5	-0.1	-0.5	0.7
Pulse wave reflection index	1.6	2.0	2.9	0.7	1.6	-1.7
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.7	-0.1	-0.9	0.1
Loud music exposure frequency	2.1	2.3	4.6	-2.1	-1.3	0.8
Qualifications: O levels/GCSEs or equivalent	1.4	2.3	5.7	0.4	-2.4	1.0
Mouth/teeth dental problems: Bleeding gums	2.0	2.5	4.0	-0.9	-2.0	1.7
Blood clot in the leg (DVT)	0.3	0.3	0.7	-0.2	0.9	-0.5
Medication: Paracetamol	0.9	1.5	2.6	1.6	1.3	0.3
Headache pain in last month	0.2	0.3	0.7	0.8	0.4	0.2
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	2.6	-0.1	-0.6	1.6
Glaucoma (self-reported)	0.4	0.5	1.0	0.0	1.0	-0.7
Gout (self-reported)	1.5	2.0	4.5	-0.1	2.1	-1.2
Hypothyroidism/myxoedema (self-reported)	0.0	0.0	0.1	-0.1	0.3	0.0
Medication: Amlodipine	0.4	0.6	0.9	0.7	-0.8	0.9
Medication: Ventolin 100micrograms inhaler	0.5	0.7	1.1	-0.8	0.6	-1.1
Birth weight	1.8	3.9	9.3	0.3	3.0	-1.5
Chronic bronchitis/emphysema (mother)	0.8	0.9	1.8	-0.2	-1.0	1.3
High blood pressure (siblings)	0.8	1.2	2.0	1.2	0.5	1.4
Forced vital capacity (FVC), Best measure	0.4	1.3	1.6	1.3	-1.2	0.9
Body fat percentage	0.7	2.7	8.0	0.1	2.8	0.1
Leg fat percentage (right)	0.5	1.7	5.2	-0.0	2.3	-0.0
Arm fat-free mass (right)	0.9	4.4	6.4	-1.4	2.5	-2.2
Exposure to tobacco smoke outside home	1.3	1.7	2.8	-0.2	-1.5	1.7
Comparative body size at age 10	0.3	0.7	2.2	-1.5	0.1	-0.2
Number of full brothers	0.7	0.9	1.6	1.3	1.0	0.5
Worry too long after embarrassment	0.3	0.5	1.3	1.1	-0.2	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.3	-0.4	-0.6	0.3
Wheeze or whistling in the chest in last year	1.9	3.4	7.9	-2.8	0.0	-1.5
Number of children fathered	3.0	3.3	3.4	-1.9	1.8	-1.8
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	2.2	1.4	1.5	-0.0
Age at first live birth	0.2	0.4	1.0	0.4	1.0	-0.2
Pulse wave peak to peak time	2.0	2.3	4.8	-0.0	-1.5	2.2
Health satisfaction	1.6	2.0	3.7	1.2	1.9	-0.9
Shortness of breath walking on level ground	2.1	2.5	3.7	-0.9	1.7	-1.9
Qualifications: College or University degree	0.4	1.3	2.9	1.7	0.9	0.3
Eye problems/disorders: None of the above	1.9	2.2	4.5	1.0	-1.1	2.1
Mouth/teeth dental problems: Loose teeth	2.7	3.2	4.8	2.0	-1.0	2.2
Emphysema/chronic bronchitis	0.4	0.5	0.8	-0.2	0.7	-0.9
Medication for pain relief, constipation, heartburn	0.2	0.4	0.9	-1.0	0.6	0.1
Neck or shoulder pain in last month	0.5	0.7	1.3	-0.7	0.5	-1.1
Medication: Blood pressure	0.6	1.1	2.1	-0.0	1.1	-1.4
Angina (self-reported)	0.1	0.2	0.5	-0.7	0.1	-0.2
Migraine (self-reported)	1.4	1.8	3.1	-1.1	1.0	-1.8
Medication: Ibuprofen	0.3	0.4	0.6	0.8	-0.5	0.5
Medication: Allopurinol	1.1	1.5	2.6	0.4	1.6	-1.3
Medication: Omeprazole	0.8	0.9	1.7	-0.1	1.0	-1.3
Medication: Seretide 50 evohaler	0.3	0.4	0.6	-0.1	0.8	0.7
Mean time to correctly identify matches	0.3	0.6	1.4	0.1	0.6	1.2
Heart disease (mother)	1.0	1.2	3.2	-1.8	-0.6	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.5	3.0	7.5	-2.7	0.8	-0.9
Whole body fat mass	1.1	4.6	12.6	-0.4	3.6	-0.9
Leg fat mass (right)	0.9	3.3	9.5	-0.0	3.1	-0.7
Arm predicted mass (right)	0.8	4.3	5.9	-1.4	2.4	-2.3
Pulse rate, automated reading	0.2	0.8	1.9	0.1	-1.4	-0.7
Alcohol intake frequency.	2.4	5.6	6.2	-2.3	2.3	-2.5
Comparative height size at age 10	3.9	21.2	37.6	-2.8	4.2	-6.1
Number of full sisters	1.5	1.9	4.5	1.0	2.1	-0.3
Suffer from ‘nerves’	0.3	0.5	1.3	1.1	0.5	-0.2
Overall health rating	0.9	2.0	3.1	0.3	1.7	-1.8
Chest pain or discomfort	0.2	0.3	0.4	0.0	-0.7	-0.6
Had major operations	0.5	0.6	0.9	0.9	-0.9	0.2
Age at last live birth	1.6	2.4	6.8	0.1	2.6	-0.6
Family relationship satisfaction	0.8	1.0	2.0	0.9	-0.4	1.4
Leg pain on walking	0.9	1.2	2.8	0.4	1.7	-0.7
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	0.9	-0.8	-1.0	-0.2
Commuting to job workplace: Car/motor vehicle	1.1	1.3	2.9	0.9	1.7	-0.3
Illness, injury, bereavement, stress in last 2 years	2.6	3.2	5.3	0.6	-2.3	2.0
Medication: Aspirin	0.3	0.4	0.8	-0.5	-0.9	-0.1
Supplements: Vitamin C	0.8	1.0	2.2	-0.8	0.2	-1.5
Knee pain experienced in last month	0.2	0.3	0.8	-0.1	-0.2	-0.9
Hypertension (Self-reported)	1.4	3.9	7.7	0.5	2.8	-1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.2	-0.5	-0.1	0.3
Illnesses of father: Heart disease	0.6	0.8	2.2	-0.3	-1.5	-0.4
Illnesses of siblings: Diabetes	0.4	0.5	1.0	-1.0	0.2	-0.6
Smoking status: Previous	1.3	2.0	3.7	0.8	-1.3	1.9
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	4.1	-0.7	0.7	-2.0
Whole body fat-free mass	1.0	5.5	7.6	-1.6	2.5	-2.8
Leg fat-free mass (right)	0.6	3.2	5.2	-1.1	2.3	-1.8
Arm fat percentage (left)	0.5	1.8	4.0	0.8	2.0	0.9
Average weekly red wine intake	0.2	0.3	0.7	-0.4	0.9	-0.1
Handedness (chirality/laterality): Left-handed	1.2	1.5	2.5	1.6	-1.3	0.5
Mood swings	0.2	0.3	0.5	0.1	-0.7	0.7
Loneliness, isolation	0.3	0.4	0.8	0.9	0.0	0.5
Long-standing illness, disability or infirmity	1.8	2.8	5.0	-2.2	0.5	-1.8
Ever had bowel cancer screening	0.9	1.1	2.1	0.9	1.4	-0.6
Diabetes diagnosed by doctor	0.9	1.5	2.2	-1.5	-0.6	-1.4
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	2.1	1.4	0.0	0.5
Friendships satisfaction	0.7	0.8	2.3	0.3	-0.2	1.5
Qualifications: nursing, teaching	0.2	0.3	0.9	-0.2	1.0	0.1
Commuting to job workplace: Walk	0.5	0.6	0.9	-0.1	-0.9	0.9
Eye problems/disorders: Cataract	1.6	1.8	2.9	-0.3	1.6	-1.7
Mouth/teeth dental problems: Mouth ulcers	0.5	0.7	2.1	0.2	-1.5	0.2
Medication for cholesterol	0.2	0.2	0.4	0.7	-0.4	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.5	-0.1	-0.1	-1.2
Back pain experienced in last month	0.8	1.1	2.4	-1.5	0.5	-0.9
Mineral and other dietary supplements	0.4	0.6	1.5	1.2	0.5	0.1
Breast cancer (self-reported)	0.8	0.9	2.2	-1.5	0.5	-0.6
Asthma (self-reported)	2.6	5.1	10.0	-3.2	1.6	-1.7
Osteoporosis (self-reported)	0.1	0.1	0.3	0.5	0.1	0.0
Osteoarthritis (self-reported)	1.5	1.9	3.2	0.2	1.8	-1.6
Medication: Aspirin	0.1	0.1	0.4	-0.1	-0.6	0.1
Medication: Gliclazide	1.1	1.3	2.6	-0.8	0.8	-1.6
Illnesses of father: None of the above (group 1)	0.5	0.6	0.7	0.8	0.7	-0.8
Smoking status: Current	0.4	0.7	1.7	0.5	-0.3	1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.6	5.6	7.9	2.1	-2.1	2.8
Whole body water mass	1.0	5.5	7.3	-1.6	2.5	-2.7
Leg predicted mass (right)	0.6	3.1	4.9	-1.2	2.2	-1.8
Arm fat mass (left)	0.6	2.5	7.3	0.4	2.7	0.1
Number of self-reported non-cancer illnesses	0.9	1.6	1.9	-1.4	1.1	-1.3
Average weekly champagne plus white wine intake	0.4	0.5	0.9	-0.8	-0.9	-0.1
Miserableness	0.7	1.1	1.6	0.4	-1.3	1.3
Guilty feelings	0.2	0.3	0.5	0.4	-0.4	-0.7
Wears glasses or contact lenses	0.4	0.5	0.9	-0.4	0.7	-0.9
Ever taken oral contraceptive pill	1.9	2.1	5.2	-0.6	-2.3	0.8
Hearing aid user	0.4	0.5	0.9	-0.4	-0.9	0.6
Mother’s age at death	1.1	1.4	1.6	1.3	-1.3	1.1
Financial situation satisfaction	2.9	3.6	6.7	2.0	-0.2	2.6
Tinnitus: Yes, now most or all of the time	1.5	1.8	3.6	1.9	1.2	0.6
Commuting to job workplace: Public transport	1.3	1.6	2.7	1.7	0.2	1.4
Eye problems/disorders: Glaucoma	0.2	0.2	0.7	0.8	0.2	-0.1
Medication: Blood pressure	0.2	0.5	0.7	-0.1	0.8	-0.8
Pain type(s) experienced in last month: Hip pain	1.3	1.6	4.1	-0.5	0.6	-2.0
Supplements: Fish oil (including cod liver oil)	1.2	1.6	2.5	-0.8	-1.6	1.4
High cholesterol (Self-reported)	0.3	0.6	1.2	-0.1	1.1	-0.7
Medication: Bendroflumethiazide	2.8	4.3	8.4	1.0	2.9	-1.8
Medication: Paracetamol	0.6	1.0	1.9	1.4	1.0	0.3
Medication: Lisinopril	2.1	2.7	5.0	-1.7	0.5	-2.2
Medication: Atorvastatin	0.3	0.4	1.3	-1.1	-0.0	-0.2
Illnesses of father: High blood pressure	0.6	0.7	1.3	-0.6	0.8	1.1
Alcohol drinker status: Never	1.1	1.3	2.1	-1.4	0.3	-1.3
Ever smoked	1.4	2.4	5.8	0.5	-1.1	2.4
Basal metabolic rate	1.0	5.7	8.2	-1.5	2.9	-2.6
Leg fat percentage (left)	0.4	1.3	3.6	0.2	1.9	0.6
Arm fat-free mass (left)	0.9	4.8	6.9	-1.4	2.6	-2.4
Number of operations (self-reported)	0.4	0.5	1.4	1.2	-0.1	0.4
Average weekly beer plus cider intake	0.8	1.2	1.9	1.2	1.4	-0.5
Irritability	0.1	0.2	0.4	0.7	0.1	0.3
Risk taking	0.8	1.1	3.2	-1.8	-0.5	-0.1
Ever had prostate specific antigen (PSA) test	4.2	4.9	11.6	0.8	-1.6	3.4
Fractured/broken bones in last 5 years	0.2	0.2	0.4	-0.3	0.4	-0.6
Age started oral contraceptive pill	0.7	0.9	2.1	-0.2	-1.4	0.7
Diastolic blood pressure, automated reading	1.2	3.8	7.7	1.9	2.8	-0.4
Ever depressed for a whole week	0.6	0.7	1.3	-0.8	-0.4	-1.1
Unable to work because of sickness or disability	0.5	0.7	1.0	0.7	-0.8	1.0
Commuting to job workplace: Cycle	0.5	0.6	1.3	-1.1	-0.5	-0.6
Myopia	0.3	0.5	1.0	-0.6	1.0	0.1
Vascular/heart problems diagnosed by doctor	0.9	2.4	5.0	-0.5	-2.2	1.4
Cholesterol lowering medication	0.8	1.2	2.2	-1.0	0.6	-1.5
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.7	0.3	0.5	-0.8
Pain experienced in last month	0.7	1.1	2.5	1.6	-0.2	0.9
Supplements: Calcium	0.9	1.0	3.0	-1.7	-0.1	0.1
Basal cell carcinoma (self-reported)	1.3	1.6	2.2	-1.3	-1.5	0.9
Heart attack/myocardial infarction (self-reported)	0.9	1.1	3.1	-0.4	-1.8	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.6	0.2	0.8	-0.4
Heart disease (siblings)	0.2	0.3	0.5	-0.5	0.4	-0.7
Alcohol drinker status: Previous	2.9	3.3	6.4	-2.5	0.7	-1.7
Pack years of smoking	0.5	0.7	1.0	-1.0	0.3	-1.0
Impedance of whole body	0.3	1.4	2.6	-0.2	1.3	-1.6
Leg fat mass (left)	0.7	2.6	7.8	-0.0	2.8	-0.3
Arm predicted mass (left)	1.0	4.9	6.5	-1.5	2.5	-2.5