Best TWAS P=1.77e-18 · Best GWAS P=1.81e-15 conditioned to 0.207
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Visceral Omentum | NCOA1 | 0.11 | 0.02 | enet | 17 | 0.02 | 2.1e-02 | -5.7 | -6.5 | 6.1e-11 | 0.39 | 0.18 | 0.08 | FALSE |
2 | GTEx | Artery Aorta | NCOA1 | 0.15 | 0.00 | enet | 15 | 0.01 | 1.4e-01 | -4.2 | -6.2 | 6.4e-10 | 0.61 | 0.04 | 0.52 | FALSE |
3 | GTEx | Cells EBV-transformed lymphocytes | ADCY3 | 0.25 | 0.23 | enet | 10 | 0.12 | 9.2e-05 | -3.1 | 5.3 | 8.8e-08 | -0.36 | 0.72 | 0.10 | FALSE |
4 | GTEx | Colon Sigmoid | DNMT3A | 0.19 | -0.01 | lasso | 8 | 0.00 | 4.5e-01 | -6.2 | -8.8 | 1.8e-18 | 0.53 | 0.04 | 0.50 | TRUE |
5 | GTEx | Esophagus Muscularis | NCOA1 | 0.11 | 0.01 | enet | 9 | 0.01 | 5.8e-02 | -6.3 | -5.8 | 5.1e-09 | 0.20 | 0.08 | 0.08 | FALSE |
6 | YFS | Blood | CENPO | 0.09 | 0.06 | lasso | 6 | 0.07 | 6.7e-21 | -5.8 | 5.8 | 6.7e-09 | -0.20 | 1.00 | 0.00 | FALSE |
7 | The Cancer Genome Atlas | Glioblastoma Multiforme | ADCY3 | 0.36 | 0.14 | enet | 7 | 0.13 | 8.9e-05 | -6.4 | 7.5 | 6.6e-14 | -0.37 | 0.00 | 0.95 | FALSE |
8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ADCY3 | 0.08 | 0.03 | enet | 16 | 0.03 | 1.5e-04 | -5.9 | 7.0 | 3.0e-12 | -0.28 | 0.01 | 0.62 | TRUE |
9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | POMC | 0.16 | 0.05 | blup | 39 | 0.11 | 2.4e-12 | 4.2 | 5.2 | 1.8e-07 | -0.33 | 0.98 | 0.01 | TRUE |
10 | The Cancer Genome Atlas | Lung Adenocarcinoma | DNAJC27 | 0.05 | 0.01 | blup | 46 | 0.04 | 3.2e-05 | -3.0 | 5.2 | 2.0e-07 | -0.38 | 0.70 | 0.19 | FALSE |
11 | The Cancer Genome Atlas | Lung Adenocarcinoma | UBXN2A | 0.05 | 0.00 | blup | 46 | 0.01 | 1.3e-02 | -2.3 | 5.6 | 2.4e-08 | -0.10 | 0.01 | 0.25 | FALSE |
12 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | EFR3B | 0.26 | 0.01 | lasso | 4 | 0.05 | 3.8e-03 | -6.3 | -5.2 | 1.6e-07 | 0.35 | 0.03 | 0.10 | FALSE |
13 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ATAD2B | 0.15 | 0.02 | enet | 33 | 0.03 | 1.4e-04 | -2.1 | 6.1 | 9.8e-10 | -0.08 | 0.01 | 0.04 | TRUE |