Hub : Genes

HOGA1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2530	0.0490	2.6e-13	0.161	0.165	0.215	0.227	0.212	4.3e-19	1.3e-19	1.0e-25	3e-27	2.7e-25
2	GTEx	Nerve Tibial	0.1643	0.0562	2.9e-03	0.090	NA	0.085	NA	0.071	6.5e-07	NA	1.3e-06	NA	9.7e-06
3	GTEx	Thyroid	0.2600	0.0620	5.3e-07	0.373	NA	0.359	NA	0.372	5.7e-30	NA	1.4e-28	NA	7.3e-30
4	ROSMAP	Brain Pre-frontal Cortex	0.0561	0.0227	8.3e-04	0.007	0.028	0.027	0.030	0.021	3.4e-02	1.4e-04	1.7e-04	9e-05	9.5e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	4.7	7.4	16.0	-3.1	-0.2	-2.0	-4.0
Bipolar Disorder or Schizophrenia	1.6	3.9	11.1	-1.4	1.4	-0.9	-3.3
Depressed Affect (Nagel 2018)	0.1	0.3	0.4	0.6	-0.6	0.5	-0.4
Depression (Nagel 2018)	1.0	1.5	2.7	1.6	0.4	1.6	0.7
Intelligence (Savage-Jansen 2018)	3.1	9.6	15.6	-2.9	-0.5	-3.8	-3.9
Neuroticism (Nagel 2018)	2.7	6.4	10.7	3.3	0.7	3.1	2.3
Schizophrenia (2018)	0.6	1.1	2.8	0.7	1.7	0.5	-1.0
Schizophrenia vs Biploar Disorder	5.6	7.4	14.1	3.8	2.0	2.2	2.6
Worry (Nagel 2018)	4.9	10.3	15.5	3.9	1.0	3.9	3.1
Alzheimer’s Disease (in mother)	1.0	1.2	2.8	-0.9	0.5	-1.0	-1.7
Alzheimer’s Disease (in father)	0.7	0.8	1.8	-0.5	-0.1	-1.0	-1.3
Alzheimer’s Disease (including proxy)	1.4	2.0	5.3	-1.2	0.3	-1.0	-2.3
Crohns Disease (2017)	0.1	0.3	0.5	-0.7	-0.5	0.2	-0.4
Irritable Bowel Disease (IBD)	0.2	0.4	1.4	0.1	-1.2	0.2	-0.4
Ulcerative Colitis (UC)	0.3	0.6	1.9	0.5	-1.4	0.2	-0.3
Major Depression (MDD)	2.5	3.0	4.7	-1.7	0.9	-2.2	-1.9
Reaction Time	1.4	2.6	4.3	-1.8	1.1	-1.3	-2.1
Verbal and Numeric Reasoning (VNR)	2.0	4.8	11.9	-1.9	0.6	-1.9	-3.5
Breast Cancer	0.7	1.6	2.4	1.3	0.9	1.2	1.5
Ovarian Cancer	0.7	0.9	2.6	-1.6	-0.8	-0.7	-0.3
Prostate Cancer	0.3	0.4	1.1	-0.6	1.0	-0.0	-0.5
Age at First Birth	0.2	0.3	0.7	-0.4	0.5	-0.2	-0.9
Bipolar Disorder (2011)	2.4	2.4	6.4	-1.7	0.0	0.0	-2.5
Body Mass Index (BMI) (2010)	1.2	1.6	3.5	1.9	0.0	1.3	1.2
Coronary Artery Disease (CAD)	0.6	0.7	2.5	1.6	0.0	0.0	0.6
Crohns Disease (2012)	0.2	0.3	0.7	-0.8	-0.5	0.1	-0.5
Mean Putamen Volume	0.9	1.1	2.2	0.8	1.2	-0.2	1.5
Fasting Glucose	0.5	0.6	1.1	0.6	0.2	0.9	-1.1
HbA1C	0.2	0.2	0.7	0.8	0.3	-0.1	0.1
HDL Cholesterol	0.9	1.6	3.7	1.5	0.0	0.6	1.9
LDL Cholesterol	0.1	0.1	0.3	0.0	0.0	-0.6	-0.1
Lupus	1.5	2.2	2.8	-1.3	-1.3	-1.7	-1.6
Neuroticism (2016)	0.5	0.8	1.6	1.3	-0.0	0.9	0.7
Primary Biliary Cirrhosis	2.1	3.0	6.8	-0.8	-2.6	-0.9	-1.9
Rheumatoid Arthritis	1.8	2.5	4.7	1.2	-2.2	1.8	0.6
Schizophrenia (2014)	0.7	1.5	3.0	1.4	1.7	1.1	-0.4
Triglycerides	0.8	1.2	1.9	-1.4	0.0	-1.3	-1.1
Type 2 Diabetes (T2D) (2012)	1.4	1.6	2.8	-1.7	0.0	-1.2	-1.5
Ulcerative Colitis	0.5	0.7	1.3	1.1	-1.1	0.0	0.5
Blood Eosinophil Count	1.2	8.9	21.9	2.0	-1.5	2.7	4.7
Blood Platelet Count	0.1	1.5	3.1	0.5	1.5	0.7	1.8
Blood Red Count	1.0	9.9	18.4	-4.3	-0.2	-3.3	-3.2
Blood White Count	10.6	78.4	210.2	6.3	1.1	7.9	14.5
Heel T-Score	0.1	0.8	1.4	-0.8	1.2	0.8	-0.8
BMI	1.1	6.3	13.6	-3.1	0.8	-1.1	-3.7
Height	0.1	2.6	5.4	2.3	-1.2	1.4	1.2
Waist Hip Ratio (WHR)	0.5	2.2	4.6	-0.8	-0.2	-2.1	-1.9
Systolic Blood Pressure	0.0	0.1	0.2	-0.1	0.4	-0.1	-0.4
Smoking Status	0.3	0.7	1.2	1.1	0.7	0.8	0.7
Allergy or Eczema	0.1	0.3	0.3	-0.6	0.4	-0.6	-0.5
Cardiovascular Disease	0.4	1.4	5.6	0.4	2.4	-0.0	0.2
Hypothyroidism (self reported)	0.1	0.3	1.0	0.0	1.0	0.1	-0.3
Respiratory disease	0.2	0.5	2.0	-0.4	1.4	-0.1	-0.1
Type 2 Diabetes (T2D) (2018)	1.3	2.5	4.0	-1.3	1.5	-1.4	-2.0
Lung FEV1/FVC ratio	1.3	6.4	11.0	-3.3	-1.9	-2.8	-1.8
Lung FVC	1.2	6.0	9.6	-2.0	2.4	-3.1	-2.2
Neuroticism	0.3	0.7	1.3	1.0	0.2	0.7	1.1
Chronotype (morning person)	0.3	0.8	1.6	0.8	-0.3	0.8	1.3
Hair Pigment	0.0	0.1	0.3	-0.4	0.1	0.5	-0.0
Tanning	0.0	0.5	0.9	-0.6	-0.9	-0.7	-0.3
Hand grip strength (left)	1.1	2.9	7.6	-0.9	-0.4	-1.8	-2.8
Number of treatments/medications taken	1.5	2.7	8.3	1.0	-0.3	2.9	1.1
Average weekly spirits intake	1.7	2.1	4.5	2.1	0.2	1.9	0.7
Sensitivity / hurt feelings	0.5	0.9	1.8	-0.6	0.5	-1.3	1.1
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.2	0.5	0.4	-0.2	-0.2
Hearing difficulty/problems: Yes	1.3	2.0	5.4	-1.1	-0.3	-1.1	-2.3
Relative age of first facial hair	0.1	0.2	0.4	0.2	0.6	-0.3	-0.3
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	2.8	0.0	0.3	0.9	-1.7
Ever used hormone-replacement therapy (HRT)	1.3	1.6	5.4	-0.4	-2.3	-0.6	-0.8
Ever had hysterectomy (womb removed)	0.4	0.5	1.0	-0.8	-0.5	-0.0	-1.0
Systolic blood pressure, automated reading	0.3	0.8	1.6	-1.3	-0.3	-0.3	-1.1
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	2.4	-1.6	-0.6	-0.5	0.2
Angina	0.4	0.5	0.8	-0.2	-0.9	0.9	-0.7
Medication for hormone replacement therapy	1.3	1.4	3.6	-0.8	-1.2	-0.0	-1.9
Vitamin and mineral supplements	1.3	1.8	4.4	-0.8	-1.4	-0.6	-2.1
Supplements: Zinc	0.1	0.1	0.3	-0.2	0.6	-0.0	-0.4
Medication: Co-codamol	1.6	1.8	2.9	-1.7	-1.3	-1.3	-1.0
Medication: Metformin	2.5	3.6	4.1	-1.9	1.8	-2.0	-1.8
Diabetes (father)	0.7	0.8	1.8	-0.9	0.6	-0.6	-1.4
Diabetes (mother)	3.2	4.0	7.0	-2.0	0.7	-2.2	-2.6
Severe depression (siblings)	3.2	3.6	8.3	-1.7	-0.3	-1.7	-2.9
Pack years adult smoking proportion	1.2	1.8	2.8	1.6	1.7	0.3	1.2
Impedance of leg (right)	0.1	0.4	1.3	0.1	-1.1	-0.5	0.1
Leg fat-free mass (left)	0.0	0.3	0.9	-0.1	1.0	0.2	-0.2
Trunk fat percentage	0.5	2.1	4.7	-1.6	2.2	-0.4	-1.1
Hand grip strength (right)	1.1	3.0	8.9	-0.8	-0.7	-1.4	-3.0
Townsend deprivation index at recruitment	0.1	0.1	0.5	-0.2	-0.1	-0.7	0.0
Current tobacco smoking	0.5	0.9	2.9	1.7	0.5	0.3	0.5
Average weekly fortified wine intake	2.8	3.2	5.4	2.3	-0.9	2.1	1.6
Maternal smoking around birth	0.0	0.1	0.1	0.2	0.4	0.1	-0.1
Fed-up feelings	0.0	0.1	0.1	-0.4	-0.2	-0.3	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	2.0	2.6	3.9	1.9	1.1	2.0	1.4
Relative age voice broke	0.9	1.4	4.1	0.3	2.0	-0.0	1.1
Taking other prescription medications	0.1	0.2	0.7	-0.3	0.0	0.9	-0.2
Age when periods started (menarche)	0.4	0.9	2.0	0.1	-1.4	0.2	-1.3
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	2.0	-0.4	-1.4	0.4	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	2.4	-1.2	0.1	-0.3	-1.5
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.1	-0.1	-0.4	0.3	-0.3
Qualifications: CSEs or equivalent	1.1	1.5	3.8	1.1	-0.1	0.9	1.9
Serious illness, injury or assault to yourself	1.9	2.3	4.9	-1.1	-2.2	-1.2	-1.3
High blood pressure	0.4	1.2	3.5	0.1	1.9	1.1	0.5
Hayfever, allergic rhinitis or eczema	0.4	0.9	1.6	-0.9	0.5	-1.3	-0.8
Multivitamins +/- minerals	2.1	2.7	4.9	1.4	1.5	1.3	2.2
Stomach or abdominal pain in last month	1.1	1.3	2.7	1.6	0.2	1.2	1.1
Supplements: Glucosamine	0.5	0.6	1.7	0.3	-1.3	-0.8	-0.1
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.5	-0.9	-1.2	-0.7	0.4
Medication: Atenolol	0.2	0.3	0.8	-0.6	-0.1	0.2	0.9
Medication: Levothyroxine sodium	0.4	0.7	2.3	0.6	0.3	1.5	0.5
Sitting height	0.1	0.6	1.4	0.5	-1.2	-0.1	0.8
Chronic bronchitis/emphysema (father)	1.2	1.4	3.0	1.7	1.3	0.2	0.9
High blood pressure (mother)	0.4	0.6	0.8	-0.7	-0.9	-0.7	0.8
Body mass index (BMI)	0.7	3.0	4.9	-1.9	2.2	-0.6	-1.8
Impedance of leg (left)	0.1	0.4	1.1	-0.1	-1.0	-0.8	0.1
Leg predicted mass (left)	0.0	0.3	0.9	-0.1	0.9	0.2	-0.3
Trunk fat mass	0.4	1.8	3.1	-1.5	1.8	-0.3	-1.3
Waist circumference	1.1	4.1	5.9	-2.4	2.1	-1.2	-2.1
Number of incorrect matches in round	0.5	0.8	2.4	0.6	1.6	0.3	0.5
Past tobacco smoking	0.3	0.5	1.0	-1.0	0.2	-0.6	-0.7
Alcohol usually taken with meals	3.8	6.1	11.1	-3.3	-0.5	-2.0	-3.0
Nervous feelings	4.7	8.8	16.3	3.3	0.7	2.8	4.0
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.9	0.5	1.0	-0.2	0.3
Hearing difficulty/problems with background noise	0.7	1.1	3.1	0.3	-0.7	-0.9	-1.8
Hair/balding pattern: Pattern 2	0.3	0.4	0.8	-0.4	0.9	-0.2	-0.7
Had menopause	0.3	0.4	1.0	0.4	1.0	0.7	0.0
Had other major operations	1.6	2.0	5.5	0.5	1.0	2.3	-1.1
Forced vital capacity (FVC)	0.8	3.0	7.4	-1.3	-0.3	-2.7	-1.7
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	1.9	-1.4	0.9	-0.3	-1.1
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.2	-0.3	1.1	-1.0	-0.7
Qualifications: None of the above	0.6	1.2	3.3	0.7	-0.0	0.9	1.8
Financial difficulties in last 2 years	0.4	0.6	1.7	-0.5	0.1	-0.6	-1.3
Mouth/teeth dental problems	0.2	0.2	0.7	-0.5	-0.3	-0.8	-0.0
Heart attack	0.5	0.7	1.2	-1.1	-1.0	0.5	-0.4
Allergy	0.3	0.7	1.4	0.6	-0.6	0.8	1.2
Pain all over the body in last month	0.7	0.8	1.8	0.8	-0.7	0.4	1.3
Diabetes (self-reported)	0.9	1.3	1.9	-1.2	1.1	-1.4	-0.8
Hayfever/allergic rhinitis (self-reported)	0.3	0.5	1.0	-0.2	0.7	0.5	-1.0
Medication: Ramipril	0.1	0.1	0.2	-0.1	0.4	0.3	-0.4
Medication: Simvastatin	1.4	2.0	3.7	-1.9	1.1	-0.3	-1.8
Fluid intelligence score	3.2	6.5	17.6	-1.9	1.0	-2.0	-4.2
Illnesses of siblings	1.0	1.5	3.6	1.0	0.2	1.1	1.9
Neuroticism score	0.2	0.4	1.1	0.5	-0.0	0.2	1.0
Weight	0.3	1.5	2.4	-1.3	1.6	-0.3	-1.4
Impedance of arm (right)	0.5	2.2	6.0	1.5	-0.4	0.7	2.5
Arm fat percentage (right)	0.6	2.3	4.7	-1.7	2.2	-0.5	-1.1
Trunk fat-free mass	0.1	0.3	1.0	-0.3	-0.5	-0.1	-1.0
Hip circumference	0.2	1.0	2.1	-1.3	1.4	0.4	-0.2
Time employed in main current job	1.0	1.2	2.9	0.4	0.2	1.3	1.7
Alcohol intake versus 10 years previously	0.6	0.9	3.2	-1.8	0.2	-0.5	-0.4
Father’s age at death	0.0	0.1	0.1	-0.1	0.3	-0.4	-0.0
Worrier / anxious feelings	2.6	4.9	6.2	2.2	1.6	2.5	2.5
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.6	0.8	0.3	-0.1	-0.3
Falls in the last year	0.2	0.3	0.6	-0.2	-0.4	-0.8	-0.7
Hair/balding pattern: Pattern 3	0.5	0.7	2.7	0.3	-1.6	0.1	0.1
Number of live births	1.2	1.7	4.1	-1.3	-0.4	-2.0	-1.0
Forced expiratory volume in 1-second (FEV1)	1.3	4.5	9.0	-2.0	-0.8	-3.0	-2.1
Pulse rate	1.0	1.7	3.9	2.0	0.2	1.7	0.3
Happiness	0.6	0.7	2.5	-0.1	0.2	-0.6	-1.6
Noisy workplace	0.9	1.1	2.8	1.0	-0.4	0.5	1.7
Qualifications: A levels/AS levels or equivalent	1.3	2.8	6.0	-1.6	-0.7	-1.4	-2.4
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	0.4	-0.6	0.6	-0.6	-0.6
Mouth/teeth dental problems: Dentures	0.8	1.4	3.0	0.8	0.5	1.2	1.7
Asthma	0.3	0.7	1.4	-0.8	0.1	-0.8	-1.2
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	3.2	0.5	-0.4	1.8	-1.3
Medication: Cholesterol lowering	0.3	0.4	0.8	-0.8	0.3	-0.5	-0.9
Depression (self-reported)	0.8	0.9	1.7	0.2	0.7	-1.3	1.2
Medication: Lansoprazole	0.6	0.7	2.5	0.1	0.5	1.6	0.3
Prospective memory result	1.1	1.4	2.9	0.6	-1.7	0.5	1.4
Lung cancer (father)	0.7	0.8	2.5	0.6	0.1	0.7	1.6
Illnesses of mother	0.5	0.6	1.7	0.3	1.3	0.6	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.2	9.7	-2.3	0.0	-3.1	-1.3
Pulse wave Arterial Stiffness index	0.3	0.3	0.8	0.1	0.2	0.7	-0.9
Impedance of arm (left)	0.3	1.4	2.8	1.3	-0.6	0.9	1.7
Arm fat mass (right)	0.5	2.1	4.5	-1.6	2.1	-0.5	-1.0
Trunk predicted mass	0.1	0.4	1.0	-0.4	-0.6	-0.2	-1.0
Standing height	0.1	1.1	2.6	1.1	-1.6	0.5	0.5
Length of working week for main job	1.4	1.5	3.1	1.8	-0.5	1.5	0.6
Exposure to tobacco smoke at home	1.7	1.9	3.3	1.0	1.8	1.1	1.4
Breastfed as a baby	0.6	0.8	1.5	-1.2	1.1	-0.1	-0.6
Tense / ‘highly strung’	0.6	1.1	1.5	0.2	1.1	1.2	1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.6	2.5	7.4	-1.0	0.7	-1.0	-2.7
Hair/balding pattern: Pattern 4	0.2	0.5	0.9	0.9	0.0	1.0	0.2
Birth weight of first child	1.8	3.3	9.8	1.4	-0.2	1.2	3.1
Peak expiratory flow (PEF)	1.8	4.2	6.6	-1.7	-2.6	-2.1	-1.7
Pulse wave reflection index	0.2	0.2	0.4	0.6	0.7	0.3	-0.2
Ever highly irritable/argumentative for 2 days	1.5	1.7	4.0	-1.5	0.8	-2.0	-0.4
Loud music exposure frequency	1.3	1.4	2.2	1.4	1.5	0.3	1.2
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.8	0.9	-0.7	-0.2	-0.1
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	1.9	-1.3	-1.4	-1.1	-1.2
Blood clot in the leg (DVT)	0.6	0.8	1.8	1.4	0.3	0.5	-1.0
Medication: Paracetamol	1.8	3.0	9.1	0.8	-3.0	1.4	0.6
Headache pain in last month	0.2	0.4	0.8	-0.5	-0.7	0.9	-0.2
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	1.5	1.2	-1.2	0.3	0.8
Glaucoma (self-reported)	0.2	0.2	0.5	-0.3	-0.7	-0.4	0.3
Gout (self-reported)	1.8	2.5	6.1	-0.7	-2.5	0.7	-1.8
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.5	0.0	0.7	0.5	-0.5
Medication: Amlodipine	0.3	0.4	1.0	-0.6	1.0	-0.2	-0.4
Medication: Ventolin 100micrograms inhaler	0.0	0.0	0.1	-0.1	0.0	0.1	-0.3
Birth weight	0.7	1.5	4.4	0.3	-1.0	0.7	2.1
Chronic bronchitis/emphysema (mother)	1.0	1.1	2.8	0.6	1.0	-0.4	1.7
High blood pressure (siblings)	0.7	1.0	3.4	-0.3	0.1	-0.5	-1.9
Forced vital capacity (FVC), Best measure	0.6	2.0	5.6	-1.3	-0.0	-2.4	-1.0
Body fat percentage	0.6	2.5	4.8	-1.7	2.2	-0.4	-1.4
Leg fat percentage (right)	0.7	2.5	5.6	-1.5	2.4	-0.5	-1.4
Arm fat-free mass (right)	0.2	1.1	3.4	-0.9	-0.4	-0.4	-1.8
Exposure to tobacco smoke outside home	4.2	5.5	8.9	3.0	1.4	1.9	2.8
Comparative body size at age 10	1.1	2.9	8.4	-1.2	2.9	-0.9	1.1
Number of full brothers	1.0	1.2	2.5	-0.3	0.3	-1.6	-1.5
Worry too long after embarrassment	1.6	2.7	3.9	1.7	0.5	1.9	2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	1.9	-0.2	-0.0	-0.6	-1.4
Wheeze or whistling in the chest in last year	0.6	1.0	2.3	1.5	1.2	-0.3	0.6
Number of children fathered	1.8	2.1	6.0	2.4	0.6	1.3	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.5	-1.2	1.2	0.2	-0.5
Age at first live birth	0.4	0.8	1.9	-0.2	0.8	-1.4	-0.7
Pulse wave peak to peak time	0.2	0.3	0.7	0.0	-0.3	-0.5	0.8
Health satisfaction	1.2	1.6	3.5	-1.5	-0.2	-1.9	-0.9
Shortness of breath walking on level ground	1.3	1.6	2.5	-1.2	0.3	-1.6	-1.5
Qualifications: College or University degree	0.5	1.6	3.7	-1.0	-1.1	-0.8	-1.9
Eye problems/disorders: None of the above	0.3	0.4	1.0	0.8	-1.0	-0.2	-0.1
Mouth/teeth dental problems: Loose teeth	1.3	1.5	3.6	1.9	1.0	0.3	1.2
Emphysema/chronic bronchitis	0.4	0.4	0.9	0.6	0.3	0.6	-1.0
Medication for pain relief, constipation, heartburn	1.2	2.1	4.5	0.4	2.1	-1.5	1.3
Neck or shoulder pain in last month	0.5	0.8	2.9	-0.0	-1.7	0.0	-0.3
Medication: Blood pressure	0.2	0.3	0.4	-0.5	0.6	0.6	-0.2
Angina (self-reported)	0.3	0.4	0.9	-0.2	-0.6	1.0	-0.5
Migraine (self-reported)	0.5	0.6	1.1	-1.1	-0.8	0.2	-0.7
Medication: Ibuprofen	0.9	1.1	2.2	0.4	-0.8	1.5	-1.2
Medication: Allopurinol	1.3	1.7	5.8	0.1	-2.4	1.0	-0.3
Medication: Omeprazole	2.9	3.5	5.9	-2.4	0.3	-2.3	-1.6
Medication: Seretide 50 evohaler	0.5	0.5	1.1	0.3	-1.0	-0.2	-0.9
Mean time to correctly identify matches	1.4	2.7	4.5	-2.1	1.4	-0.8	-1.9
Heart disease (mother)	0.7	0.8	3.2	-0.0	-1.8	0.2	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.6	3.1	4.4	-1.9	-1.1	-2.1	-1.8
Whole body fat mass	0.5	1.9	3.4	-1.5	1.9	-0.3	-1.4
Leg fat mass (right)	0.5	1.8	3.7	-1.4	1.9	-0.4	-1.3
Arm predicted mass (right)	0.2	1.0	3.0	-0.9	-0.2	-0.6	-1.7
Pulse rate, automated reading	0.5	1.5	4.3	0.6	-1.1	2.1	0.2
Alcohol intake frequency.	0.2	0.6	0.8	-0.9	0.1	0.7	0.9
Comparative height size at age 10	0.2	1.3	2.5	1.2	-0.5	1.1	1.6
Number of full sisters	0.6	0.7	1.4	-0.8	0.9	-0.2	-1.2
Suffer from ‘nerves’	4.7	7.3	11.4	3.2	0.3	2.7	3.4
Overall health rating	0.2	0.4	0.8	0.4	-0.2	0.8	0.9
Chest pain or discomfort	0.6	0.8	2.9	-0.3	-0.2	-0.5	-1.7
Had major operations	0.4	0.5	1.4	0.4	0.7	1.2	0.2
Age at last live birth	0.4	0.6	2.0	0.0	0.5	-1.4	-0.2
Family relationship satisfaction	1.1	1.3	2.5	1.6	0.8	0.8	-1.2
Leg pain on walking	0.5	0.7	1.2	-0.5	-0.3	-1.1	-1.1
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	3.2	0.9	1.8	-0.3	-0.3
Commuting to job workplace: Car/motor vehicle	1.2	1.3	2.8	-0.6	-1.2	-0.9	-1.7
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	3.1	0.7	1.8	0.4	1.0
Medication: Aspirin	0.6	0.8	1.5	-1.2	-0.7	-0.2	-1.0
Supplements: Vitamin C	1.3	1.6	2.3	-1.5	0.6	-1.3	-1.4
Knee pain experienced in last month	0.2	0.3	0.9	0.3	-1.0	-0.1	-0.4
Hypertension (Self-reported)	0.5	1.3	3.7	0.3	1.9	1.1	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.5	-1.2	0.1	-0.3	-0.8
Illnesses of father: Heart disease	0.5	0.7	1.9	0.2	-0.8	-0.5	-1.4
Illnesses of siblings: Diabetes	1.1	1.4	3.0	-0.8	1.1	-0.7	-1.7
Smoking status: Previous	0.3	0.5	1.0	0.3	0.1	1.0	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	2.3	0.7	-0.3	0.5	1.5
Whole body fat-free mass	0.0	0.1	0.5	-0.2	0.1	0.0	-0.7
Leg fat-free mass (right)	0.0	0.2	0.7	-0.1	0.8	0.1	-0.2
Arm fat percentage (left)	0.6	2.4	4.3	-1.7	2.1	-0.4	-1.4
Average weekly red wine intake	2.0	2.9	5.3	-1.7	1.1	-1.5	-2.3
Handedness (chirality/laterality): Left-handed	3.0	3.6	5.2	1.6	1.9	1.7	2.3
Mood swings	0.1	0.2	0.3	0.5	0.2	-0.4	0.6
Loneliness, isolation	0.8	1.1	3.2	-0.5	-1.8	-1.0	-0.2
Long-standing illness, disability or infirmity	0.1	0.2	0.6	0.0	-0.8	-0.3	-0.2
Ever had bowel cancer screening	1.6	1.9	3.7	1.3	1.9	0.9	1.1
Diabetes diagnosed by doctor	1.1	1.8	2.0	-1.4	1.4	-1.3	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	0.7	-0.1	0.8	-0.6	-0.8
Friendships satisfaction	0.6	0.8	2.1	1.4	1.0	-0.3	0.2
Qualifications: nursing, teaching	0.7	1.1	1.8	-1.4	-1.0	-1.3	-0.4
Commuting to job workplace: Walk	0.2	0.2	0.8	-0.4	0.9	-0.0	-0.2
Eye problems/disorders: Cataract	0.9	1.1	1.6	0.0	1.1	1.1	1.3
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.4	-0.0	-0.1	-0.2	-0.6
Medication for cholesterol	0.4	0.7	1.9	-0.2	-0.6	-1.4	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.9	2.3	6.2	1.3	0.8	2.5	0.8
Back pain experienced in last month	1.5	2.1	3.1	-1.8	-1.6	-1.6	-0.5
Mineral and other dietary supplements	0.8	1.1	2.3	-1.5	0.2	-0.7	-1.2
Breast cancer (self-reported)	0.5	0.6	1.8	-0.6	-0.6	-0.0	-1.4
Asthma (self-reported)	0.3	0.6	1.2	-0.8	0.2	-0.8	-1.1
Osteoporosis (self-reported)	0.7	0.8	1.3	1.1	-0.0	1.1	0.9
Osteoarthritis (self-reported)	0.5	0.7	1.0	0.7	-1.0	0.8	0.8
Medication: Aspirin	0.1	0.1	0.2	-0.4	0.3	0.1	0.1
Medication: Gliclazide	1.2	1.3	4.4	0.1	2.1	0.9	-0.3
Illnesses of father: None of the above (group 1)	0.4	0.5	1.0	0.2	0.5	0.8	1.0
Smoking status: Current	0.3	0.5	1.6	1.3	0.6	-0.2	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.3	4.9	-1.8	0.1	-2.2	-1.0
Whole body water mass	0.0	0.2	0.8	-0.3	0.0	-0.1	-0.9
Leg predicted mass (right)	0.0	0.2	0.7	-0.2	0.9	-0.0	-0.3
Arm fat mass (left)	0.6	2.3	3.8	-1.7	1.9	-0.6	-1.5
Number of self-reported non-cancer illnesses	0.2	0.3	0.6	0.2	-0.7	0.8	-0.5
Average weekly champagne plus white wine intake	0.2	0.3	0.6	-0.5	-0.8	-0.5	-0.4
Miserableness	0.2	0.4	0.6	-0.8	-0.1	-0.8	-0.6
Guilty feelings	0.9	1.3	2.0	1.0	1.1	1.1	1.4
Wears glasses or contact lenses	0.4	0.5	0.9	0.4	-0.5	0.8	1.0
Ever taken oral contraceptive pill	0.1	0.1	0.4	0.6	0.2	-0.1	-0.4
Hearing aid user	2.5	2.8	3.9	-1.8	0.9	-1.8	-2.0
Mother’s age at death	1.3	1.6	2.1	-1.5	-1.2	-1.0	-1.4
Financial situation satisfaction	0.8	1.0	3.2	-0.5	0.4	-1.8	-0.5
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.5	0.7	-0.2	0.4	0.5
Commuting to job workplace: Public transport	0.9	1.0	3.0	0.2	1.7	0.3	1.0
Eye problems/disorders: Glaucoma	0.1	0.1	0.2	-0.2	-0.2	0.1	0.5
Medication: Blood pressure	0.8	1.5	5.6	0.0	2.4	0.4	0.5
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.8	0.4	0.5	0.9	-0.0
Supplements: Fish oil (including cod liver oil)	1.0	1.3	2.1	1.5	0.9	0.9	1.2
High cholesterol (Self-reported)	0.9	1.7	3.2	-1.3	0.8	-1.1	-1.8
Medication: Bendroflumethiazide	0.7	1.1	2.1	1.3	0.1	1.4	0.9
Medication: Paracetamol	1.4	2.1	7.4	0.4	-2.7	1.0	0.1
Medication: Lisinopril	0.4	0.5	1.4	-0.6	1.2	-0.4	-0.1
Medication: Atorvastatin	0.3	0.4	0.8	0.5	-0.9	0.2	-0.7
Illnesses of father: High blood pressure	0.6	0.8	1.8	-0.4	-0.6	-1.3	-0.8
Alcohol drinker status: Never	0.9	1.1	2.6	-1.6	-1.3	-0.2	0.3
Ever smoked	0.7	1.2	3.1	1.8	-0.4	0.8	0.8
Basal metabolic rate	0.1	0.4	0.8	-0.5	0.6	-0.2	-0.9
Leg fat percentage (left)	0.7	2.6	5.5	-1.6	2.3	-0.6	-1.4
Arm fat-free mass (left)	0.2	1.0	2.4	-1.1	0.1	-0.8	-1.6
Number of operations (self-reported)	1.2	1.8	4.4	0.4	1.2	2.1	-1.1
Average weekly beer plus cider intake	1.3	1.8	3.1	1.5	1.8	1.4	0.4
Irritability	0.8	1.4	2.3	-1.0	1.5	-1.5	-0.3
Risk taking	1.8	2.6	3.2	-1.5	1.6	-1.6	-1.8
Ever had prostate specific antigen (PSA) test	2.1	2.4	4.1	1.3	2.0	1.6	-1.1
Fractured/broken bones in last 5 years	0.4	0.5	0.9	0.6	0.5	-0.6	0.9
Age started oral contraceptive pill	3.1	3.8	6.2	-2.4	-1.6	-1.0	-2.5
Diastolic blood pressure, automated reading	0.4	1.4	2.2	-1.5	0.2	-1.0	-1.5
Ever depressed for a whole week	2.1	2.6	5.0	-0.8	-0.0	-2.2	-2.2
Unable to work because of sickness or disability	0.2	0.2	0.6	-0.5	0.8	-0.3	-0.1
Commuting to job workplace: Cycle	1.6	1.9	3.9	-0.6	0.3	-1.8	-2.0
Myopia	0.5	0.8	2.5	0.0	1.6	0.2	0.8
Vascular/heart problems diagnosed by doctor	0.4	1.0	2.0	-0.4	-1.3	-1.4	-0.1
Cholesterol lowering medication	1.6	2.4	7.4	-1.4	-0.2	-0.1	-2.7
Medication: Omeprazole (e.g. Zanprol)	2.6	3.1	4.5	-2.1	1.2	-2.0	-1.7
Pain experienced in last month	1.3	2.2	5.9	1.1	2.4	1.1	0.6
Supplements: Calcium	2.7	3.0	4.8	2.1	-0.0	1.7	2.2
Basal cell carcinoma (self-reported)	0.8	1.0	2.0	0.5	1.1	0.6	1.4
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.1	-1.1	-0.8	0.5	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	1.8	1.2	0.4	0.4	-1.3
Heart disease (siblings)	0.8	1.0	1.4	-0.8	-1.0	-1.0	-1.2
Alcohol drinker status: Previous	0.3	0.3	0.6	0.6	0.8	0.4	0.4
Pack years of smoking	1.0	1.5	2.5	1.6	1.5	0.7	0.8
Impedance of whole body	0.1	0.6	1.1	0.6	-1.0	0.1	1.0
Leg fat mass (left)	0.6	2.3	4.1	-1.6	2.0	-0.5	-1.5
Arm predicted mass (left)	0.2	0.9	2.2	-0.9	-0.1	-0.8	-1.5