Hub : Genes

ZDHHC16

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Skin Sun Exposed Lower leg	0.075	0.033	9.3e-03	-0.003	NA	0.015	NA	-0.003	8.8e-01	NA	2.0e-02	NA	7.9e-01
2	GTEx	Testis	0.412	0.079	1.2e-07	0.350	NA	0.265	NA	0.330	2.4e-16	NA	3.9e-12	NA	2.6e-15
3	TCGA	Pancreatic Adenocarcinoma	0.239	0.111	4.9e-03	-0.006	-0.007	-0.007	NA	-0.007	7.4e-01	0.99	8.7e-01	NA	8.2e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.1	0.1	0.4	-0.6	0.0	0.2
Bipolar Disorder or Schizophrenia	0.3	0.7	1.8	-1.4	-0.3	-0.5
Depressed Affect (Nagel 2018)	0.9	1.9	5.2	0.2	2.3	-0.7
Depression (Nagel 2018)	0.4	0.6	0.9	0.2	1.0	-0.8
Intelligence (Savage-Jansen 2018)	0.3	0.9	1.4	-1.2	-1.0	0.4
Neuroticism (Nagel 2018)	2.1	5.0	14.0	-0.0	3.7	-0.9
Schizophrenia (2018)	0.4	0.8	1.6	-1.3	-0.3	-0.8
Schizophrenia vs Biploar Disorder	0.9	1.2	2.5	1.1	1.6	-0.1
Worry (Nagel 2018)	1.9	4.1	9.3	0.8	3.1	-1.5
Alzheimer’s Disease (in mother)	0.9	1.0	1.5	1.2	1.1	0.6
Alzheimer’s Disease (in father)	0.9	1.0	2.2	0.4	-0.7	1.5
Alzheimer’s Disease (including proxy)	0.6	0.9	2.0	0.7	0.5	1.4
Crohns Disease (2017)	0.2	0.4	0.8	-0.6	-0.9	0.3
Irritable Bowel Disease (IBD)	0.1	0.3	0.4	-0.7	-0.4	0.5
Ulcerative Colitis (UC)	0.2	0.3	0.8	-0.2	0.9	0.3
Major Depression (MDD)	1.3	1.6	3.7	0.0	-1.9	-1.0
Reaction Time	0.3	0.7	0.8	-0.7	-0.8	0.9
Verbal and Numeric Reasoning (VNR)	0.5	1.1	1.9	-1.1	-1.4	-0.5
Breast Cancer	0.6	1.5	3.4	0.3	1.9	-1.0
Ovarian Cancer	0.3	0.5	1.2	1.1	-0.3	-0.3
Prostate Cancer	1.1	1.6	3.5	1.9	1.0	0.4
Age at First Birth	0.0	0.1	0.1	0.0	-0.1	-0.4
Bipolar Disorder (2011)	1.0	1.0	1.3	-1.1	1.1	0.7
Body Mass Index (BMI) (2010)	3.2	4.4	10.9	3.3	-1.5	0.2
Coronary Artery Disease (CAD)	0.1	0.2	0.4	0.3	-0.6	-0.2
Crohns Disease (2012)	0.5	0.8	1.9	-0.2	-1.4	0.6
Mean Putamen Volume	0.6	0.7	2.0	0.1	1.4	-0.4
Fasting Glucose	0.6	0.7	1.4	-0.5	-1.2	-0.7
HbA1C	1.7	1.9	3.0	-1.5	-1.7	0.6
HDL Cholesterol	0.4	0.6	1.0	0.2	-1.0	0.9
LDL Cholesterol	0.4	0.7	1.3	-0.4	0.7	1.1
Lupus	1.2	1.9	4.7	-2.2	0.6	0.8
Neuroticism (2016)	2.3	3.3	8.6	-0.9	2.9	-0.8
Primary Biliary Cirrhosis	1.2	1.8	2.4	-1.5	1.5	0.7
Rheumatoid Arthritis	2.7	3.7	9.4	-0.7	3.1	-1.0
Schizophrenia (2014)	0.1	0.1	0.3	0.1	0.1	-0.6
Triglycerides	0.0	0.0	0.0	0.1	0.1	0.1
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.4	-0.0	1.2	0.2
Ulcerative Colitis	0.6	0.8	1.6	0.9	0.1	1.3
Blood Eosinophil Count	0.5	3.5	8.8	3.0	1.1	-0.6
Blood Platelet Count	0.6	6.6	14.3	3.8	-2.3	-0.7
Blood Red Count	0.0	0.2	0.4	-0.6	0.3	-0.3
Blood White Count	4.3	31.7	67.2	8.2	4.4	-3.0
Heel T-Score	0.7	5.8	17.3	0.2	-4.2	-0.3
BMI	0.2	1.1	2.6	0.8	-1.6	-0.4
Height	0.6	10.7	19.3	3.6	4.4	0.4
Waist Hip Ratio (WHR)	0.4	1.8	3.2	-1.8	-0.7	-1.3
Systolic Blood Pressure	0.2	1.2	2.6	0.2	-0.9	-1.6
Smoking Status	0.0	0.1	0.1	-0.1	0.4	-0.2
Allergy or Eczema	1.0	2.7	7.3	-0.3	-2.7	0.9
Cardiovascular Disease	0.3	1.1	2.2	0.3	-1.5	-1.0
Hypothyroidism (self reported)	0.1	0.2	0.3	0.3	-0.5	-0.5
Respiratory disease	0.8	1.9	4.8	2.2	-0.9	0.2
Type 2 Diabetes (T2D) (2018)	1.2	2.2	5.3	0.2	-2.3	-1.1
Lung FEV1/FVC ratio	0.4	2.1	5.3	-1.0	-2.3	0.0
Lung FVC	0.7	3.4	7.3	-0.9	-2.7	1.4
Neuroticism	1.8	4.3	11.7	0.8	3.4	-0.9
Chronotype (morning person)	0.1	0.3	0.4	-0.4	-0.7	-0.6
Hair Pigment	0.0	0.8	2.1	-0.1	0.5	1.5
Tanning	0.1	0.6	1.7	-0.3	-1.3	0.3
Hand grip strength (left)	0.9	2.5	5.1	-0.3	-2.2	1.5
Number of treatments/medications taken	1.7	3.1	7.5	2.7	0.6	-1.1
Average weekly spirits intake	0.2	0.3	0.6	-0.0	0.8	0.3
Sensitivity / hurt feelings	2.6	4.5	6.7	-2.4	2.6	-1.1
Frequency of depressed mood in last 2 weeks	0.0	0.1	0.1	-0.2	0.1	-0.3
Hearing difficulty/problems: Yes	0.5	0.7	2.0	-1.4	-0.1	0.4
Relative age of first facial hair	1.6	3.3	9.7	0.1	-3.1	-0.4
Other serious medical condition/disability diagnosed by doctor	1.3	1.7	3.2	-1.2	-0.6	1.8
Ever used hormone-replacement therapy (HRT)	1.6	2.1	3.6	1.4	-0.8	-1.9
Ever had hysterectomy (womb removed)	0.7	0.7	1.3	0.7	-0.7	-1.1
Systolic blood pressure, automated reading	0.7	2.0	5.7	-0.3	0.6	-2.4
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.0	-0.2	-0.4	-1.0
Angina	0.4	0.6	1.6	0.0	-1.3	0.4
Medication for hormone replacement therapy	0.4	0.5	1.3	1.1	-0.3	-0.1
Vitamin and mineral supplements	0.3	0.5	0.7	-0.8	0.3	-0.8
Supplements: Zinc	0.1	0.1	0.3	0.0	0.5	0.2
Medication: Co-codamol	1.6	1.9	2.0	1.4	-1.3	1.4
Medication: Metformin	0.3	0.5	1.3	0.2	-0.4	-1.1
Diabetes (father)	1.3	1.6	4.3	2.1	-0.3	-0.5
Diabetes (mother)	1.1	1.5	3.1	1.1	-1.8	0.1
Severe depression (siblings)	2.4	2.7	8.0	0.2	-2.8	0.3
Pack years adult smoking proportion	2.4	3.6	10.0	-0.2	-3.2	-0.9
Impedance of leg (right)	0.1	0.5	1.3	-0.2	0.2	-1.1
Leg fat-free mass (left)	0.3	1.5	3.2	1.8	0.8	0.7
Trunk fat percentage	0.5	1.8	5.2	0.3	-0.5	-2.3
Hand grip strength (right)	0.9	2.4	5.5	0.1	-2.4	1.3
Townsend deprivation index at recruitment	1.0	1.3	2.9	1.7	-0.3	1.0
Current tobacco smoking	0.8	1.2	3.7	-0.0	-1.9	0.1
Average weekly fortified wine intake	1.1	1.3	3.5	1.9	-0.5	0.2
Maternal smoking around birth	1.7	2.5	7.4	-2.7	0.3	-0.1
Fed-up feelings	1.0	1.8	4.0	-0.9	2.0	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	1.3	0.6	1.1	-1.1
Relative age voice broke	0.4	0.6	1.3	0.7	-0.1	-1.1
Taking other prescription medications	1.9	3.0	6.4	2.5	-0.6	-1.5
Age when periods started (menarche)	0.1	0.2	0.4	0.5	0.1	-0.6
Bilateral oophorectomy (both ovaries removed)	1.1	1.2	3.3	1.8	-0.6	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.0	1.4	-1.2	-0.8	1.0
Tinnitus: Yes, but not now, but have in the past	1.0	1.0	2.1	0.6	0.7	-1.5
Qualifications: CSEs or equivalent	0.1	0.2	0.4	0.0	-0.3	-0.7
Serious illness, injury or assault to yourself	2.2	2.7	7.6	-0.1	-2.8	0.6
High blood pressure	0.5	1.4	2.8	1.1	-0.0	-1.7
Hayfever, allergic rhinitis or eczema	0.8	1.7	5.1	-0.1	-2.2	0.1
Multivitamins +/- minerals	1.7	2.2	5.4	0.9	-0.6	2.3
Stomach or abdominal pain in last month	4.2	5.3	11.5	3.4	-2.1	-0.2
Supplements: Glucosamine	1.2	1.6	1.9	-1.2	1.2	1.4
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	0.8	0.5	0.9	-0.6
Medication: Atenolol	0.4	0.5	0.6	0.8	-0.6	0.8
Medication: Levothyroxine sodium	0.4	0.7	2.0	-0.2	-0.1	-1.4
Sitting height	0.3	2.4	4.9	2.2	1.4	0.6
Chronic bronchitis/emphysema (father)	0.7	0.8	2.1	-0.1	-1.4	-0.6
High blood pressure (mother)	1.4	1.9	5.2	0.1	-0.8	-2.3
Body mass index (BMI)	0.1	0.3	0.6	-0.3	-0.8	-0.4
Impedance of leg (left)	0.2	0.8	1.6	-1.0	0.0	-1.3
Leg predicted mass (left)	0.3	1.5	3.2	1.8	0.8	0.8
Trunk fat mass	0.2	0.8	2.1	0.6	0.1	-1.4
Waist circumference	0.1	0.5	0.9	-0.6	0.6	-1.0
Number of incorrect matches in round	0.6	1.0	2.1	-1.4	-0.6	-0.6
Past tobacco smoking	0.8	1.5	2.7	-0.8	-1.7	1.1
Alcohol usually taken with meals	1.0	1.6	2.5	-1.6	1.4	-0.6
Nervous feelings	1.6	3.0	8.3	0.8	2.9	0.0
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.3	-0.6	0.1	-0.3
Hearing difficulty/problems with background noise	0.9	1.5	3.4	-1.9	0.9	-0.3
Hair/balding pattern: Pattern 2	0.1	0.1	0.1	-0.4	0.0	-0.4
Had menopause	1.4	1.7	2.5	-1.2	-1.1	-1.6
Had other major operations	0.3	0.3	0.7	0.4	0.3	0.8
Forced vital capacity (FVC)	0.7	2.5	6.7	-0.0	-0.9	2.6
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	2.3	-0.6	-0.9	1.5
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.3	-0.1	-1.2	-0.1
Qualifications: None of the above	0.4	0.8	1.3	1.1	0.4	-0.9
Financial difficulties in last 2 years	2.0	2.7	4.8	-2.2	-1.2	-1.3
Mouth/teeth dental problems	1.8	2.8	6.8	0.9	-2.6	0.9
Heart attack	0.5	0.7	0.9	1.0	-0.9	0.7
Allergy	0.6	1.3	3.2	-0.6	1.8	0.5
Pain all over the body in last month	0.1	0.1	0.1	-0.2	-0.2	-0.4
Diabetes (self-reported)	1.4	2.1	3.3	1.8	-0.7	-1.6
Hayfever/allergic rhinitis (self-reported)	1.9	2.5	4.6	-1.7	-2.1	-0.4
Medication: Ramipril	2.0	2.6	4.7	2.2	-1.7	-0.5
Medication: Simvastatin	0.3	0.4	0.8	0.9	-0.6	0.3
Fluid intelligence score	0.8	1.7	4.7	-0.5	-2.2	0.4
Illnesses of siblings	1.1	1.5	3.0	0.1	1.7	1.2
Neuroticism score	2.2	4.6	12.7	-0.5	3.6	-0.9
Weight	0.1	0.3	0.4	0.7	0.6	0.1
Impedance of arm (right)	0.5	2.3	7.0	-0.0	-0.0	-2.6
Arm fat percentage (right)	0.3	1.4	2.6	-0.4	-1.1	-1.6
Trunk fat-free mass	0.4	2.1	3.3	1.1	1.4	1.8
Hip circumference	0.2	0.8	1.9	0.3	1.4	-0.6
Time employed in main current job	0.1	0.1	0.3	-0.0	0.6	0.3
Alcohol intake versus 10 years previously	0.6	0.9	1.4	1.2	0.6	-1.0
Father’s age at death	1.2	1.7	1.7	1.3	1.3	-1.3
Worrier / anxious feelings	2.1	4.0	8.5	-1.4	2.9	-1.3
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.6	0.8	-0.0	-0.7
Falls in the last year	0.8	1.1	1.6	-1.3	-0.1	-1.2
Hair/balding pattern: Pattern 3	0.4	0.6	1.0	-0.6	-1.0	0.6
Number of live births	1.1	1.5	3.4	0.3	-1.9	1.0
Forced expiratory volume in 1-second (FEV1)	1.0	3.2	6.9	-0.6	-1.6	2.6
Pulse rate	0.2	0.4	1.1	0.2	0.2	-1.0
Happiness	1.0	1.2	2.9	-0.7	0.3	-1.7
Noisy workplace	0.4	0.4	1.0	0.0	0.6	-1.0
Qualifications: A levels/AS levels or equivalent	1.2	2.7	4.5	-2.1	0.4	1.9
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	2.4	0.3	-1.5	-1.0
Mouth/teeth dental problems: Dentures	1.3	2.1	3.3	1.8	0.2	-1.8
Asthma	0.2	0.4	1.0	1.0	-0.3	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	1.3	1.1	1.1	-0.7
Medication: Cholesterol lowering	0.2	0.3	0.5	0.3	-0.5	0.7
Depression (self-reported)	1.4	1.7	3.3	1.8	-1.1	0.8
Medication: Lansoprazole	0.5	0.6	1.3	1.1	-0.0	-0.7
Prospective memory result	0.4	0.5	0.7	-0.1	0.9	-0.8
Lung cancer (father)	0.1	0.2	0.3	-0.2	0.3	0.6
Illnesses of mother	0.5	0.6	1.5	-0.1	0.5	1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	2.6	0.3	-1.6	1.6
Pulse wave Arterial Stiffness index	1.4	1.6	4.1	-0.6	2.0	-0.7
Impedance of arm (left)	0.5	2.2	6.2	0.7	-0.2	-2.5
Arm fat mass (right)	0.1	0.3	0.6	-0.1	-0.5	-0.8
Trunk predicted mass	0.4	2.1	3.3	1.2	1.3	1.8
Standing height	0.4	3.8	6.9	1.9	2.6	0.9
Length of working week for main job	2.1	2.3	4.2	-2.1	1.1	-1.3
Exposure to tobacco smoke at home	0.4	0.4	0.6	0.8	-0.7	0.4
Breastfed as a baby	1.5	1.9	3.0	-1.7	1.5	0.4
Tense / ‘highly strung’	1.1	1.8	2.9	0.8	1.4	-1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	2.3	-0.2	-1.5	0.1
Hair/balding pattern: Pattern 4	0.2	0.6	0.9	0.6	0.9	-0.7
Birth weight of first child	1.2	2.2	5.9	2.4	0.7	0.6
Peak expiratory flow (PEF)	1.1	2.5	4.4	-1.2	-1.3	2.1
Pulse wave reflection index	0.8	1.0	2.7	-1.6	0.3	-0.4
Ever highly irritable/argumentative for 2 days	0.9	1.0	2.3	-0.9	-1.5	0.1
Loud music exposure frequency	0.5	0.5	0.8	-0.5	-0.7	-0.9
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	2.2	-1.5	0.0	0.8
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	3.6	-0.4	1.9	0.7
Blood clot in the leg (DVT)	0.2	0.3	0.5	-0.5	0.7	0.3
Medication: Paracetamol	0.6	1.0	2.9	0.2	1.7	0.0
Headache pain in last month	0.7	1.2	3.3	1.8	0.6	0.1
Medication for cholesterol, blood pressure or diabetes	0.0	0.1	0.1	-0.4	-0.2	0.0
Glaucoma (self-reported)	0.6	0.6	1.1	0.5	1.1	-0.7
Gout (self-reported)	1.4	1.9	4.4	1.1	2.1	0.1
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	0.8	0.2	-0.3	-0.9
Medication: Amlodipine	0.3	0.4	0.9	-0.1	-0.9	-0.6
Medication: Ventolin 100micrograms inhaler	0.9	1.2	2.4	1.6	0.3	-1.0
Birth weight	0.4	0.9	1.4	1.2	-0.0	1.1
Chronic bronchitis/emphysema (mother)	0.6	0.7	0.9	1.0	-0.7	-0.7
High blood pressure (siblings)	1.8	2.6	4.7	-1.8	-2.2	0.1
Forced vital capacity (FVC), Best measure	0.3	1.3	3.1	0.5	-0.7	1.8
Body fat percentage	0.4	1.6	4.4	-0.0	-0.5	-2.1
Leg fat percentage (right)	0.2	0.7	1.9	-0.2	-0.2	-1.4
Arm fat-free mass (right)	0.4	2.0	3.2	1.3	1.1	1.8
Exposure to tobacco smoke outside home	0.3	0.4	0.9	0.6	1.0	-0.1
Comparative body size at age 10	0.1	0.2	0.6	0.1	-0.7	-0.4
Number of full brothers	0.6	0.7	1.2	-1.1	-1.0	-0.0
Worry too long after embarrassment	3.6	6.0	10.6	-2.6	3.3	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.8	4.0	-1.2	-2.0	0.2
Wheeze or whistling in the chest in last year	0.5	0.9	1.4	0.7	-0.8	-1.2
Number of children fathered	0.8	0.9	1.9	-0.2	0.8	-1.4
Reason for reducing amount of alcohol drunk: Health precaution	2.6	3.0	5.4	1.3	-1.4	2.3
Age at first live birth	1.1	1.9	3.6	0.9	-1.9	1.1
Pulse wave peak to peak time	1.1	1.3	3.2	0.6	-1.8	0.7
Health satisfaction	1.7	2.2	5.3	0.7	-2.3	-1.0
Shortness of breath walking on level ground	1.0	1.2	2.6	-0.3	-1.6	-0.9
Qualifications: College or University degree	0.8	2.5	3.9	-1.8	0.7	2.0
Eye problems/disorders: None of the above	0.8	0.9	2.2	-0.6	-0.3	1.5
Mouth/teeth dental problems: Loose teeth	1.5	1.7	3.2	-1.2	1.8	0.8
Emphysema/chronic bronchitis	1.4	1.6	4.0	0.7	-2.0	-0.4
Medication for pain relief, constipation, heartburn	0.2	0.4	1.0	-0.3	-0.1	1.0
Neck or shoulder pain in last month	0.3	0.4	1.2	1.1	-0.1	0.1
Medication: Blood pressure	0.5	1.0	2.1	1.5	-0.6	-0.7
Angina (self-reported)	0.4	0.5	1.4	-0.1	-1.2	0.4
Migraine (self-reported)	1.4	1.7	5.0	-0.0	2.2	0.4
Medication: Ibuprofen	1.2	1.4	3.6	0.8	1.9	-0.1
Medication: Allopurinol	1.1	1.5	3.1	1.1	1.8	-0.3
Medication: Omeprazole	2.9	3.5	6.1	1.9	-2.5	-0.9
Medication: Seretide 50 evohaler	0.3	0.3	0.9	-1.0	-0.1	0.0
Mean time to correctly identify matches	0.3	0.5	1.0	-1.0	-0.7	-0.0
Heart disease (mother)	0.4	0.4	0.6	-0.8	-0.5	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.0	0.0	0.1	-0.1	0.2
Whole body fat mass	0.1	0.5	1.2	0.6	-0.1	-1.1
Leg fat mass (right)	0.1	0.4	0.8	0.6	0.3	-0.9
Arm predicted mass (right)	0.3	1.5	2.2	1.3	0.9	1.5
Pulse rate, automated reading	0.7	2.3	4.5	0.2	2.1	-1.5
Alcohol intake frequency.	0.1	0.1	0.2	0.3	-0.4	0.3
Comparative height size at age 10	0.4	2.2	3.4	1.9	1.6	0.7
Number of full sisters	1.7	2.1	3.3	-1.8	-1.7	-0.1
Suffer from ‘nerves’	0.4	0.6	1.0	0.8	1.0	-0.5
Overall health rating	0.2	0.4	0.5	0.5	-0.7	-0.6
Chest pain or discomfort	0.7	1.1	2.3	-1.5	-0.6	-0.7
Had major operations	0.0	0.0	0.0	-0.2	-0.2	0.0
Age at last live birth	1.5	2.2	2.5	1.6	-1.5	1.4
Family relationship satisfaction	0.4	0.5	0.8	-0.6	-0.5	0.9
Leg pain on walking	0.2	0.2	0.6	-0.8	-0.2	-0.2
Qualifications: NVQ or HND or HNC or equivalent	1.7	2.1	3.4	-1.5	-0.7	1.8
Commuting to job workplace: Car/motor vehicle	1.5	1.7	4.8	0.4	-2.2	-0.5
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	0.7	-0.4	0.8	0.5
Medication: Aspirin	0.5	0.6	1.6	-0.1	-1.3	-0.4
Supplements: Vitamin C	0.9	1.1	2.0	-1.0	1.4	0.5
Knee pain experienced in last month	0.3	0.5	1.1	0.4	0.6	-1.0
Hypertension (Self-reported)	0.3	0.8	1.9	0.7	0.0	-1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.0	3.5	7.5	2.7	-1.7	-0.0
Illnesses of father: Heart disease	1.7	2.4	4.6	0.3	-2.1	-1.6
Illnesses of siblings: Diabetes	0.6	0.8	2.0	-0.5	-0.1	-1.4
Smoking status: Previous	1.6	2.4	6.2	0.5	2.5	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	1.4	1.2	0.9	0.6
Whole body fat-free mass	0.3	1.6	1.9	1.4	1.1	1.3
Leg fat-free mass (right)	0.2	0.9	1.8	1.4	0.6	0.7
Arm fat percentage (left)	0.3	1.3	2.2	-0.2	-1.3	-1.5
Average weekly red wine intake	0.5	0.7	1.3	-1.1	0.3	0.9
Handedness (chirality/laterality): Left-handed	0.5	0.6	0.8	0.9	0.8	0.5
Mood swings	0.9	1.7	2.9	-1.7	1.4	0.1
Loneliness, isolation	0.7	1.0	2.6	-0.1	1.6	-0.7
Long-standing illness, disability or infirmity	1.3	2.0	4.9	2.2	1.0	0.2
Ever had bowel cancer screening	0.7	0.8	1.2	-0.8	-0.7	-1.1
Diabetes diagnosed by doctor	1.2	2.0	2.8	1.5	-0.9	-1.7
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	0.8	0.6	-0.9	-0.5
Friendships satisfaction	1.1	1.4	2.5	-0.8	-1.6	-1.0
Qualifications: nursing, teaching	0.3	0.5	1.3	0.3	-0.4	1.2
Commuting to job workplace: Walk	0.8	0.8	1.4	-0.5	1.2	0.9
Eye problems/disorders: Cataract	1.2	1.4	2.2	0.4	1.3	-1.5
Mouth/teeth dental problems: Mouth ulcers	1.7	2.8	5.2	-1.6	2.3	-0.8
Medication for cholesterol	0.2	0.4	0.7	-0.6	-0.2	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.0	1.0	0.9	0.3
Back pain experienced in last month	0.2	0.3	0.8	0.9	0.4	-0.1
Mineral and other dietary supplements	1.7	2.3	6.2	0.8	-2.5	0.3
Breast cancer (self-reported)	0.5	0.6	1.2	-0.4	-1.1	0.7
Asthma (self-reported)	0.3	0.5	1.5	1.2	-0.2	-0.2
Osteoporosis (self-reported)	2.0	2.5	7.2	2.7	0.6	0.1
Osteoarthritis (self-reported)	0.2	0.3	0.6	0.2	0.8	-0.4
Medication: Aspirin	0.5	0.7	1.6	-0.1	-1.2	-0.7
Medication: Gliclazide	0.3	0.3	0.5	0.6	-0.4	-0.7
Illnesses of father: None of the above (group 1)	1.5	1.8	3.2	0.1	1.5	1.8
Smoking status: Current	1.2	1.8	5.5	-0.1	-2.3	0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	3.0	6.7	-0.4	-2.6	1.5
Whole body water mass	0.3	1.6	2.0	1.2	1.1	1.4
Leg predicted mass (right)	0.2	0.9	1.7	1.3	0.5	0.8
Arm fat mass (left)	0.1	0.4	0.6	0.2	-0.7	-0.8
Number of self-reported non-cancer illnesses	1.4	2.4	3.7	1.9	-1.5	-1.0
Average weekly champagne plus white wine intake	0.6	0.8	2.1	-0.4	-1.5	0.4
Miserableness	1.1	1.8	4.8	-0.4	2.2	0.7
Guilty feelings	2.4	3.5	9.9	0.5	3.1	0.7
Wears glasses or contact lenses	1.3	1.6	4.3	0.1	0.6	-2.1
Ever taken oral contraceptive pill	2.7	3.0	4.5	0.7	-2.1	2.0
Hearing aid user	0.4	0.5	0.6	-0.7	-0.8	-0.6
Mother’s age at death	1.7	2.1	6.1	-0.4	2.5	-0.2
Financial situation satisfaction	2.2	2.7	3.7	-1.9	-0.8	-1.9
Tinnitus: Yes, now most or all of the time	0.0	0.0	0.1	0.0	0.3	-0.3
Commuting to job workplace: Public transport	1.5	1.8	1.9	-1.2	1.4	1.4
Eye problems/disorders: Glaucoma	0.9	1.0	1.7	0.6	1.3	-1.0
Medication: Blood pressure	0.5	0.9	2.7	0.2	-0.3	-1.6
Pain type(s) experienced in last month: Hip pain	2.2	2.8	7.3	-0.0	1.0	-2.7
Supplements: Fish oil (including cod liver oil)	1.6	2.1	4.8	-0.1	2.2	-1.2
High cholesterol (Self-reported)	0.3	0.5	1.0	-0.1	-0.7	-1.0
Medication: Bendroflumethiazide	1.4	2.1	2.4	-1.6	1.4	-1.4
Medication: Paracetamol	1.0	1.5	4.3	-0.1	2.1	0.5
Medication: Lisinopril	0.4	0.6	1.4	0.2	1.2	-0.5
Medication: Atorvastatin	0.1	0.1	0.3	-0.6	-0.3	0.1
Illnesses of father: High blood pressure	0.9	1.2	1.6	-0.5	-1.3	-1.3
Alcohol drinker status: Never	0.1	0.2	0.4	-0.2	0.1	0.7
Ever smoked	0.6	1.0	1.5	1.0	1.2	-0.7
Basal metabolic rate	0.2	1.1	1.4	1.2	0.9	1.1
Leg fat percentage (left)	0.3	0.9	2.1	-0.7	-0.4	-1.4
Arm fat-free mass (left)	0.3	1.3	2.6	0.7	0.8	1.6
Number of operations (self-reported)	0.3	0.4	1.0	1.0	-0.2	0.2
Average weekly beer plus cider intake	0.5	0.7	2.0	1.4	-0.0	0.2
Irritability	0.1	0.2	0.4	0.6	-0.2	-0.2
Risk taking	1.2	1.8	3.8	-1.1	-2.0	0.6
Ever had prostate specific antigen (PSA) test	2.2	2.5	5.5	-2.4	1.4	-0.4
Fractured/broken bones in last 5 years	1.4	1.8	5.0	2.2	-0.7	-0.2
Age started oral contraceptive pill	0.9	1.2	2.3	-1.5	0.9	0.6
Diastolic blood pressure, automated reading	0.5	1.5	3.3	-1.0	-0.3	-1.8
Ever depressed for a whole week	1.8	2.2	5.4	-1.0	-2.3	-0.2
Unable to work because of sickness or disability	1.1	1.5	4.2	-0.1	-2.0	-0.4
Commuting to job workplace: Cycle	1.9	2.3	5.3	0.2	-2.3	1.3
Myopia	0.1	0.1	0.2	0.3	0.5	0.3
Vascular/heart problems diagnosed by doctor	0.3	0.7	1.4	-0.8	-0.3	1.2
Cholesterol lowering medication	0.3	0.5	1.0	-0.6	-0.3	-1.0
Medication: Omeprazole (e.g. Zanprol)	3.5	4.3	8.7	1.5	-3.0	-1.4
Pain experienced in last month	0.4	0.6	1.2	-1.1	-0.3	0.8
Supplements: Calcium	1.1	1.3	2.6	1.1	1.6	-0.1
Basal cell carcinoma (self-reported)	0.8	1.0	2.2	0.8	1.5	-0.1
Heart attack/myocardial infarction (self-reported)	0.8	1.0	1.4	1.2	-1.1	0.7
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.5	-0.7	0.5	0.1
Heart disease (siblings)	1.3	1.6	3.7	0.8	-0.7	-1.9
Alcohol drinker status: Previous	1.1	1.2	2.8	-0.7	-1.7	0.7
Pack years of smoking	2.1	3.1	8.0	-0.4	-2.8	-1.0
Impedance of whole body	0.3	1.4	4.1	0.3	-0.1	-2.0
Leg fat mass (left)	0.1	0.4	0.9	0.2	0.3	-1.0
Arm predicted mass (left)	0.2	1.1	2.4	0.6	0.9	1.5