Hub : Genes

EXOSC1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0570 0.0240 4.6e-03 0.053 0.000 0.020 0.015 0.032 4.6e-07 2.8e-01 1.4e-03 0.0058 6.9e-05
2 GTEx Muscle Skeletal 0.0559 0.0250 8.3e-03 -0.002 NA -0.001 NA 0.015 7.2e-01 NA 3.8e-01 NA 1.1e-02
3 ROSMAP Brain Pre-frontal Cortex 0.0406 0.0171 3.3e-03 0.008 0.013 0.013 0.010 0.013 3.1e-02 7.7e-03 6.7e-03 0.0170 7.6e-03
4 YFS Blood 0.0171 0.0069 1.2e-03 0.021 0.005 0.014 0.007 0.017 1.5e-07 9.3e-03 1.9e-05 0.0019 2.7e-06
5 TCGA Brain Lower Grade Glioma 0.1354 0.0501 3.3e-06 0.044 0.050 0.047 NA 0.055 7.9e-06 2.4e-06 4.6e-06 NA 7.3e-07
6 TCGA Liver Hepatocellular Carcinoma 0.2150 0.0840 1.6e-04 0.021 0.061 0.066 NA 0.025 3.3e-02 7.7e-04 4.8e-04 NA 2.3e-02
7 TCGA Prostate Adenocarcinoma 0.0703 0.0378 5.0e-03 0.039 0.021 0.020 NA 0.023 5.5e-05 2.3e-03 3.2e-03 NA 1.5e-03
8 TCGA Thyroid Carcinoma 0.0840 0.0400 1.5e-03 0.007 0.020 0.006 NA 0.015 6.9e-02 4.5e-03 7.4e-02 NA 1.3e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bipolar Disorder (2018) 2.7 4.2 10.4 -0.8 -1.1 -3.2 -1.0 -2.5 -2.8 -1.7 -2.0
Bipolar Disorder or Schizophrenia 1.8 4.4 11.1 -1.1 -1.7 -2.9 -1.4 -1.9 -3.3 -1.5 -1.9
Depressed Affect (Nagel 2018) 0.5 1.0 2.7 -0.2 -0.5 0.2 0.2 -1.7 1.4 -0.4 -1.6
Depression (Nagel 2018) 0.1 0.1 0.2 -0.1 -0.1 0.4 -0.4 -0.3 0.3 0.3 0.2
Intelligence (Savage-Jansen 2018) 1.6 5.0 12.6 -0.7 -0.7 -3.6 -0.2 -2.8 -2.2 -1.5 -3.4
Neuroticism (Nagel 2018) 1.1 2.6 9.1 0.7 -1.5 3.0 -0.6 -0.7 2.6 0.5 -0.9
Schizophrenia (2018) 0.6 1.2 4.1 -0.7 -1.3 -1.1 -1.0 -0.4 -2.0 -0.6 -0.9
Schizophrenia vs Biploar Disorder 0.9 1.2 3.8 0.4 0.2 1.2 -0.7 1.4 1.9 0.9 1.1
Worry (Nagel 2018) 1.0 2.1 10.1 -0.1 -0.7 3.2 -0.1 -0.2 2.5 0.1 -0.6
Alzheimer’s Disease (in mother) 1.8 2.1 11.4 0.4 -3.4 -1.0 -1.3 -0.9 0.2 0.1 -1.3
Alzheimer’s Disease (in father) 2.5 2.7 13.4 -1.3 -0.1 -3.7 0.3 -1.4 -0.7 -1.5 -1.4
Alzheimer’s Disease (including proxy) 2.2 3.3 9.0 0.0 -3.0 -2.9 -1.6 -1.5 -0.8 -0.4 -1.8
Crohns Disease (2017) 0.9 2.1 6.8 -0.1 -2.2 1.1 -2.6 -0.4 -1.6 -0.5 -0.8
Irritable Bowel Disease (IBD) 0.7 1.8 7.8 0.3 -2.3 0.6 -2.8 0.2 -0.8 -0.3 -0.2
Ulcerative Colitis (UC) 0.3 0.6 2.1 -0.2 -1.3 -0.1 -1.4 -0.1 0.3 -0.8 -0.1
Major Depression (MDD) 4.0 4.9 12.1 -1.7 1.3 -3.5 1.0 -2.5 -2.6 -2.1 -2.0
Reaction Time 0.5 0.9 1.8 -0.0 -1.0 -1.3 -1.4 -0.5 -1.3 -0.9 -0.4
Verbal and Numeric Reasoning (VNR) 2.5 5.9 15.1 -1.5 -0.3 -3.9 -0.3 -2.7 -3.1 -2.0 -3.0
Breast Cancer 0.2 0.5 2.1 -0.0 0.3 0.9 1.1 0.1 1.5 0.0 -0.0
Ovarian Cancer 0.3 0.3 1.5 0.5 0.3 0.2 -0.4 0.2 -1.2 0.6 0.5
Prostate Cancer 0.4 0.6 2.3 0.4 -1.2 -0.1 0.0 -0.5 1.5 -0.1 -0.7
Age at First Birth 0.7 1.0 2.2 -1.3 -0.8 -0.5 0.8 -0.8 0.8 -1.3 -1.5
Bipolar Disorder (2011) 3.3 3.2 5.6 -0.3 -1.6 -1.8 -1.6 -2.4 -2.3 -1.4 -2.0
Body Mass Index (BMI) (2010) 1.5 2.0 3.9 -1.9 1.7 -1.8 2.0 -1.1 -0.3 -1.1 0.0
Coronary Artery Disease (CAD) 0.8 0.9 4.3 -1.0 0.4 -2.1 0.6 -0.4 -0.9 -0.6 0.1
Crohns Disease (2012) 0.3 0.4 1.3 0.3 -0.6 0.4 -1.1 0.8 -0.8 0.2 0.5
Mean Putamen Volume 0.4 0.4 1.2 1.1 -0.9 0.4 -0.8 -0.1 -0.3 0.6 -0.2
Fasting Glucose 3.5 4.2 8.8 -2.1 1.3 -3.0 0.9 -2.0 -2.5 -2.4 -1.4
HbA1C 0.2 0.2 0.6 0.3 -0.1 -0.7 0.0 0.8 -0.3 0.6 0.5
HDL Cholesterol 0.2 0.3 0.7 -0.2 0.5 0.5 0.3 0.7 -0.6 0.3 0.9
LDL Cholesterol 1.2 2.0 4.4 -0.7 -1.4 -1.3 -0.8 -2.0 -1.0 -1.2 -2.1
Lupus 0.4 0.6 1.4 -0.2 -1.0 -0.5 -0.8 -0.9 -1.2 -0.2 -1.0
Neuroticism (2016) 0.8 1.2 3.2 0.5 -1.0 1.8 -0.8 -0.3 1.8 -0.0 -0.9
Primary Biliary Cirrhosis 1.0 1.4 5.0 1.2 -1.1 0.7 -2.2 -0.3 -1.4 0.9 0.4
Rheumatoid Arthritis 0.8 1.1 5.3 -0.3 -0.7 2.3 0.1 0.2 1.7 -0.4 0.2
Schizophrenia (2014) 0.4 0.8 2.8 -0.4 -0.8 -1.2 -0.7 -0.3 -1.7 -0.3 -0.6
Triglycerides 2.0 3.2 8.4 -1.5 -1.3 -1.5 -0.1 -2.4 -1.4 -1.8 -2.9
Type 2 Diabetes (T2D) (2012) 2.0 2.3 3.8 -1.2 -1.9 -1.6 -1.2 -1.8 -0.7 -1.5 -1.9
Ulcerative Colitis 0.7 1.0 2.6 0.7 0.0 0.1 -0.2 1.5 1.6 0.3 1.5
Blood Eosinophil Count 1.1 8.5 27.5 0.9 2.1 5.2 1.6 2.3 4.1 1.6 2.8
Blood Platelet Count 0.6 7.3 20.9 -0.7 4.6 0.9 4.0 1.8 3.1 0.3 2.7
Blood Red Count 0.2 2.4 7.0 -1.0 -0.2 -2.6 0.8 -1.8 0.4 -1.4 -2.2
Blood White Count 10.9 80.5 243.4 3.7 6.0 15.6 6.5 7.7 11.9 5.6 8.8
Heel T-Score 0.2 1.5 4.4 -0.2 1.8 0.0 0.7 2.1 -1.6 0.5 1.1
BMI 0.5 2.8 16.2 -0.4 0.8 -4.0 1.1 -1.1 -1.3 -0.3 -1.1
Height 0.1 2.1 6.4 -1.2 -0.6 0.9 1.4 -2.5 1.7 -1.5 -1.0
Waist Hip Ratio (WHR) 0.1 0.5 2.5 1.6 0.4 0.2 -0.0 0.3 0.4 1.1 0.3
Systolic Blood Pressure 0.1 0.4 0.8 -0.9 0.7 -0.5 0.4 0.3 -0.2 -0.9 -0.7
Smoking Status 0.2 0.5 1.3 -0.9 0.2 -0.3 0.7 -1.1 -0.1 -0.7 -0.8
Allergy or Eczema 1.0 2.6 7.2 0.4 2.3 -0.9 1.3 1.7 1.1 1.2 2.7
Cardiovascular Disease 0.4 1.2 2.3 -1.3 1.5 -1.0 1.3 -1.0 -0.5 -1.1 -0.9
Hypothyroidism (self reported) 0.3 0.6 2.0 1.1 0.1 -0.1 -0.4 0.9 -0.1 1.4 0.7
Respiratory disease 2.4 5.4 10.0 -2.8 2.4 -3.2 2.9 -1.9 -0.5 -2.6 -0.9
Type 2 Diabetes (T2D) (2018) 0.3 0.6 2.4 -0.2 -0.0 -1.4 -0.4 0.2 -1.5 0.2 -0.1
Lung FEV1/FVC ratio 0.1 0.6 1.5 0.8 0.8 -1.2 0.2 0.8 -0.5 0.7 0.9
Lung FVC 0.4 2.1 6.1 -0.1 -0.9 -2.5 -1.1 -0.8 -2.3 0.0 -1.7
Neuroticism 0.8 1.8 6.5 0.5 -1.3 2.5 -1.0 -1.2 1.5 0.0 -1.4
Chronotype (morning person) 0.7 1.6 3.6 0.9 1.8 1.9 0.0 0.9 -0.8 1.0 1.7
Hair Pigment 0.0 1.1 5.4 0.3 -0.5 1.2 0.6 0.7 2.3 0.7 0.2
Tanning 0.0 0.1 0.2 -0.0 0.2 -0.5 0.1 0.3 0.4 0.1 0.3
Hand grip strength (left) 0.8 2.1 10.1 -0.5 -0.7 -3.2 -0.1 -1.2 -1.7 -0.1 -1.3
Number of treatments/medications taken 1.0 1.8 6.4 -0.9 2.1 0.5 2.5 0.2 1.4 -0.5 0.6
Average weekly spirits intake 0.4 0.4 1.5 0.2 -0.5 0.5 0.1 1.2 1.0 0.4 0.5
Sensitivity / hurt feelings 1.4 2.4 4.3 0.2 -2.1 2.1 -1.5 -2.1 -0.6 -0.2 -2.0
Frequency of depressed mood in last 2 weeks 0.2 0.3 1.0 -0.2 -0.0 0.3 -0.3 -1.0 -0.5 -0.2 -0.8
Hearing difficulty/problems: Yes 0.8 1.2 3.8 -0.1 -0.5 -1.7 -0.4 -1.2 -1.9 -0.7 -0.9
Relative age of first facial hair 1.5 3.0 7.2 -1.9 2.7 -2.2 2.1 -0.8 -1.5 -1.0 -0.0
Other serious medical condition/disability diagnosed by doctor 0.5 0.7 2.9 0.3 -1.3 -1.7 -0.2 0.1 0.5 0.6 0.3
Ever used hormone-replacement therapy (HRT) 1.1 1.4 4.5 -0.6 1.2 -1.1 2.1 -0.8 -0.4 -0.7 -1.5
Ever had hysterectomy (womb removed) 1.0 1.1 2.3 -1.5 0.8 -0.7 1.5 -0.7 0.0 -1.2 -1.3
Systolic blood pressure, automated reading 0.0 0.1 0.9 -0.1 0.2 -0.0 -0.1 0.1 -0.1 -0.2 -0.9
Eye problems/disorders: Diabetes related eye disease 0.4 0.5 1.2 -0.1 -1.0 1.0 -1.1 0.1 -0.3 -0.4 -0.6
Angina 0.4 0.6 1.4 0.5 -0.5 -0.1 -0.9 1.2 -0.8 0.5 0.9
Medication for hormone replacement therapy 1.3 1.4 4.0 -0.8 1.4 -1.0 2.0 -0.7 -0.0 -1.2 -1.2
Vitamin and mineral supplements 0.3 0.5 1.0 0.0 -0.9 -0.9 -0.9 -0.4 -0.4 0.2 -1.0
Supplements: Zinc 0.2 0.2 0.5 -0.6 -0.7 -0.0 0.0 -0.4 -0.0 -0.7 -0.5
Medication: Co-codamol 1.1 1.3 3.5 1.0 0.1 -0.1 0.6 1.9 1.1 1.3 1.6
Medication: Metformin 0.3 0.4 1.0 -0.2 -0.3 -0.8 -0.3 -0.6 -0.9 -0.6 -1.0
Diabetes (father) 0.1 0.1 0.4 -0.1 0.1 -0.3 0.1 -0.3 -0.7 -0.5 -0.5
Diabetes (mother) 1.1 1.4 3.6 1.5 -1.1 -1.9 -1.3 0.5 -1.2 1.0 -0.1
Severe depression (siblings) 1.5 1.7 9.2 -1.1 0.9 -3.0 0.2 -0.5 -1.3 -0.6 -0.2
Pack years adult smoking proportion 1.0 1.6 5.1 -0.9 2.3 -0.9 1.4 1.1 -0.7 0.3 1.5
Impedance of leg (right) 0.4 1.9 4.4 -1.9 -0.3 1.3 0.8 -1.3 -0.5 -2.1 -1.8
Leg fat-free mass (left) 0.2 1.0 3.2 0.2 1.5 -1.8 1.2 -0.8 0.4 0.5 0.4
Trunk fat percentage 0.6 2.3 5.3 -1.4 2.3 -1.8 2.3 -0.8 -1.0 -0.9 -0.4
Hand grip strength (right) 0.8 2.1 11.8 -0.9 -0.1 -3.4 0.7 -1.1 -1.2 -0.3 -1.0
Townsend deprivation index at recruitment 0.1 0.1 0.2 -0.2 -0.1 -0.5 0.1 0.0 0.4 0.0 0.4
Current tobacco smoking 0.9 1.5 3.6 -1.9 0.9 -1.6 1.2 -0.9 -1.3 -1.0 -0.0
Average weekly fortified wine intake 1.0 1.2 2.8 -0.4 0.8 -1.0 0.7 1.2 1.6 0.3 1.7
Maternal smoking around birth 1.1 1.5 3.0 -1.1 0.6 -1.7 -0.7 -1.4 -1.4 -1.5 -0.9
Fed-up feelings 1.3 2.3 7.5 -1.3 -1.2 0.1 -0.2 -2.3 0.4 -1.5 -2.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.0 0.1 0.1 -0.2 0.2 0.3 -0.4 -0.2 0.3 0.2 0.1
Relative age voice broke 0.5 0.8 2.4 -0.8 0.3 -0.3 0.6 -1.6 -0.5 -0.9 -1.2
Taking other prescription medications 0.6 0.9 3.5 -0.6 1.8 -0.5 1.9 0.1 0.4 -0.3 0.2
Age when periods started (menarche) 0.8 2.0 4.5 -1.5 -0.5 -0.9 0.1 -1.9 -2.1 -1.7 -1.3
Bilateral oophorectomy (both ovaries removed) 1.5 1.7 5.2 0.0 1.6 -0.5 2.3 0.7 2.3 -0.1 0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.4 1.4 -0.5 0.8 -1.2 0.6 0.4 -0.5 -0.5 0.0
Tinnitus: Yes, but not now, but have in the past 2.2 2.4 6.5 -1.6 -0.5 -0.1 0.9 -2.1 -0.7 -1.9 -2.5
Qualifications: CSEs or equivalent 1.1 1.5 3.9 0.1 1.9 2.0 0.1 1.3 0.2 0.5 1.6
Serious illness, injury or assault to yourself 0.9 1.1 3.5 -0.6 1.4 -1.9 1.5 0.3 -0.5 -0.3 0.5
High blood pressure 0.2 0.6 1.2 -1.1 0.3 0.0 0.5 -0.8 -0.3 -1.1 -1.1
Hayfever, allergic rhinitis or eczema 1.0 2.2 7.3 -0.3 2.7 -1.7 1.8 0.7 0.7 0.3 1.8
Multivitamins +/- minerals 1.2 1.5 5.4 1.0 0.6 0.8 0.1 1.7 1.1 0.8 2.3
Stomach or abdominal pain in last month 1.6 2.0 4.7 -1.5 1.9 -1.9 2.2 0.6 0.6 -0.6 0.8
Supplements: Glucosamine 0.4 0.5 2.0 0.8 -1.4 -0.0 -0.5 -0.3 0.6 0.7 -0.5
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.6 -0.2 0.8 0.5 0.4 -0.2 0.4 -0.5 -0.2
Medication: Atenolol 2.1 2.6 5.5 1.6 0.8 2.0 -0.7 2.1 0.3 1.8 2.3
Medication: Levothyroxine sodium 0.9 1.5 4.2 1.6 -0.2 1.0 -0.7 1.6 0.5 2.0 1.2
Sitting height 0.2 1.1 4.2 -1.0 0.1 -0.6 0.5 -2.0 0.3 -1.4 -1.0
Chronic bronchitis/emphysema (father) 1.0 1.2 2.5 -1.6 1.5 -0.8 1.0 0.1 -1.0 -1.5 -0.0
High blood pressure (mother) 0.2 0.3 1.4 -0.3 1.2 0.2 0.4 0.0 -0.7 -0.3 -0.6
Body mass index (BMI) 0.3 1.2 5.9 0.4 1.4 -2.4 0.7 0.3 -0.7 0.8 0.3
Impedance of leg (left) 0.4 1.9 4.3 -1.7 -0.8 1.3 0.3 -1.3 -0.9 -2.1 -1.7
Leg predicted mass (left) 0.2 1.0 3.3 0.1 1.4 -1.8 1.2 -0.9 0.3 0.4 0.3
Trunk fat mass 0.5 2.1 5.0 -1.0 2.1 -2.2 2.2 -1.0 -0.5 -0.6 -0.4
Waist circumference 0.2 0.7 1.7 1.1 1.1 -1.3 0.7 -0.2 -0.1 1.0 -0.0
Number of incorrect matches in round 0.2 0.4 1.3 -0.2 0.9 -0.9 1.1 -0.2 -0.0 0.2 0.3
Past tobacco smoking 0.4 0.7 1.6 -0.1 -0.5 -0.9 -1.3 0.9 -0.8 0.0 1.2
Alcohol usually taken with meals 1.9 3.0 6.5 -1.3 -0.4 -2.4 -0.0 -2.4 -0.9 -2.0 -2.5
Nervous feelings 0.9 1.7 7.6 -0.7 0.8 2.8 0.5 -1.0 1.9 -0.6 -0.1
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 1.3 1.1 0.2 0.9 -0.4 0.7 0.6 1.1 0.7
Hearing difficulty/problems with background noise 2.0 3.2 5.7 -1.5 -1.0 -2.4 -0.2 -2.4 -1.7 -2.0 -2.1
Hair/balding pattern: Pattern 2 0.2 0.2 0.7 -0.8 -0.1 -0.3 -0.2 -0.4 -0.4 -0.8 -0.3
Had menopause 0.3 0.3 2.0 -0.6 0.2 -0.2 -0.1 0.2 -1.4 -0.3 0.1
Had other major operations 0.5 0.7 1.9 -0.4 -1.4 -1.1 -0.8 -0.4 -0.4 -0.5 -0.8
Forced vital capacity (FVC) 0.3 1.2 3.6 -0.3 -0.6 -1.9 -0.1 -1.7 -0.4 -0.4 -1.6
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.6 1.4 -1.1 0.1 -1.2 0.6 -0.1 -0.6 -1.1 -0.2
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 1.5 0.4 -1.2 -0.8 -1.1 0.0 -1.1 0.5 0.0
Qualifications: None of the above 1.1 2.4 5.2 0.4 1.6 1.7 2.3 0.9 2.0 0.9 1.4
Financial difficulties in last 2 years 0.8 1.1 2.7 0.3 1.5 -0.4 1.1 1.6 0.6 0.8 1.0
Mouth/teeth dental problems 0.2 0.4 1.3 0.2 0.6 -0.2 0.1 1.1 -0.3 -0.1 1.0
Heart attack 0.5 0.6 1.7 0.5 -0.4 -0.4 -0.8 1.3 0.7 0.8 0.9
Allergy 0.9 2.0 5.7 1.1 -2.4 2.1 -1.9 0.1 -0.4 0.7 -0.7
Pain all over the body in last month 0.7 0.8 2.7 0.4 1.3 0.7 0.0 0.9 0.2 0.8 1.6
Diabetes (self-reported) 0.1 0.1 0.7 0.3 0.3 -0.3 -0.3 0.1 -0.8 0.1 0.0
Hayfever/allergic rhinitis (self-reported) 1.1 1.5 4.4 1.3 0.3 0.5 -0.3 2.1 0.8 1.6 1.6
Medication: Ramipril 0.3 0.4 0.9 0.6 -0.6 -0.8 -0.3 -0.3 -1.0 0.6 0.0
Medication: Simvastatin 0.3 0.4 1.6 -0.2 -0.4 -1.3 0.2 -0.5 0.1 -0.5 -0.8
Fluid intelligence score 3.0 6.1 16.3 -1.2 -1.4 -4.0 -1.2 -2.2 -3.8 -1.7 -2.5
Illnesses of siblings 0.5 0.6 1.8 0.6 0.1 1.3 0.1 0.5 1.2 0.6 0.9
Neuroticism score 1.2 2.4 4.6 -0.1 -1.9 1.9 -1.6 -2.1 0.6 -0.8 -2.2
Weight 0.2 1.0 4.7 0.2 1.2 -2.2 1.1 -0.7 -0.0 0.4 -0.0
Impedance of arm (right) 0.5 2.3 14.0 -1.0 1.0 3.7 0.9 0.8 0.2 -0.8 0.6
Arm fat percentage (right) 0.3 1.2 4.0 0.3 2.0 -1.2 1.3 0.9 -0.5 0.8 0.8
Trunk fat-free mass 0.2 1.1 5.6 0.5 0.2 -2.4 0.4 -1.4 0.4 0.4 -0.6
Hip circumference 0.1 0.6 2.3 0.2 1.5 -0.8 1.1 -0.3 -0.1 0.5 0.3
Time employed in main current job 0.4 0.4 1.5 -0.8 0.1 1.2 0.4 -0.1 1.0 -0.4 -0.0
Alcohol intake versus 10 years previously 0.5 0.7 2.1 -0.8 0.2 -0.1 0.4 -1.0 -0.5 -1.3 -1.4
Father’s age at death 0.3 0.4 1.4 -0.3 0.4 -0.1 0.5 -1.2 -0.0 -0.9 -0.9
Worrier / anxious feelings 1.6 3.0 10.1 0.8 -2.4 3.2 -2.5 0.6 0.7 0.7 -0.0
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.4 1.0 -0.0 -0.3 -0.6 -0.3 -0.9 -1.0 0.0 -1.0
Falls in the last year 0.3 0.3 2.0 -0.4 1.4 -0.3 0.1 -0.1 -0.3 -0.5 0.4
Hair/balding pattern: Pattern 3 1.2 1.8 4.4 1.4 0.0 0.8 -1.7 2.1 -0.2 1.2 1.8
Number of live births 0.5 0.8 2.3 1.0 0.6 0.4 0.8 1.5 0.6 0.8 0.7
Forced expiratory volume in 1-second (FEV1) 0.4 1.3 6.0 -0.4 -0.2 -2.4 -0.0 -1.5 -0.5 -0.4 -1.3
Pulse rate 0.1 0.2 0.7 -0.2 -0.2 -0.6 0.1 0.2 0.3 -0.4 -0.8
Happiness 3.1 3.8 9.2 -1.4 -0.9 -1.0 -0.7 -2.7 -2.4 -1.9 -3.0
Noisy workplace 0.9 1.1 5.8 0.3 -0.7 2.4 -0.6 0.6 0.5 0.8 0.7
Qualifications: A levels/AS levels or equivalent 0.8 1.7 3.5 -0.1 -1.2 -0.8 -1.6 -1.4 -1.6 -1.0 -1.9
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.1 2.6 0.7 1.0 0.8 0.5 1.6 0.2 1.3 1.4
Mouth/teeth dental problems: Dentures 0.5 0.8 2.2 -0.7 1.1 0.6 1.5 0.4 1.4 -0.2 0.5
Asthma 2.0 3.9 9.7 -1.9 1.9 -3.1 1.9 -1.9 -0.4 -2.3 -1.1
Medication: Ibuprofen (e.g. Nurofen) 1.0 1.3 3.3 -1.1 -0.5 -0.5 0.7 -1.2 0.7 -1.8 -1.7
Medication: Cholesterol lowering 0.1 0.2 0.9 0.4 -0.1 -1.0 -0.5 -0.0 -0.3 0.2 -0.2
Depression (self-reported) 0.2 0.2 0.5 0.1 -0.5 0.5 -0.4 0.5 0.7 0.4 0.6
Medication: Lansoprazole 0.3 0.3 1.2 -1.1 0.7 -0.7 0.6 -0.2 0.1 -0.4 -0.2
Prospective memory result 1.5 1.8 5.7 1.0 0.8 2.4 -0.1 1.3 1.1 1.1 1.8
Lung cancer (father) 0.5 0.6 1.2 0.4 0.8 0.6 0.7 0.7 1.1 0.7 1.1
Illnesses of mother 0.2 0.2 0.6 -0.3 0.0 0.7 0.5 -0.2 0.8 -0.2 0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.3 4.1 -0.3 -0.4 -2.0 0.1 -1.7 -0.7 -0.4 -1.6
Pulse wave Arterial Stiffness index 1.8 2.1 6.0 -1.5 -0.4 -0.8 0.4 -2.1 0.7 -1.5 -2.4
Impedance of arm (left) 0.4 1.7 8.7 -1.4 0.8 3.0 1.0 0.2 -0.2 -1.2 0.2
Arm fat mass (right) 0.3 1.1 3.5 0.1 1.9 -1.8 1.3 0.2 -0.4 0.6 0.5
Trunk predicted mass 0.2 1.1 5.6 0.5 0.3 -2.4 0.5 -1.5 0.4 0.4 -0.6
Standing height 0.1 1.3 5.8 -0.7 0.1 0.0 1.2 -2.4 1.0 -0.9 -1.0
Length of working week for main job 0.3 0.4 1.7 -0.1 -0.6 1.3 0.4 -0.1 0.6 0.5 -0.4
Exposure to tobacco smoke at home 0.8 0.8 1.9 0.7 0.5 0.7 -1.0 1.0 -0.9 1.0 1.4
Breastfed as a baby 1.8 2.2 5.0 2.1 -1.5 0.5 -2.2 1.2 -0.2 1.8 1.2
Tense / ‘highly strung’ 0.4 0.6 2.5 -0.1 0.3 1.6 0.6 0.0 1.3 0.0 -0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 1.9 2.9 11.5 -0.9 -0.6 -3.4 -1.6 -1.4 -1.9 -1.2 -1.0
Hair/balding pattern: Pattern 4 0.5 1.3 2.9 1.7 -1.7 0.9 -0.9 0.3 0.5 1.5 -0.0
Birth weight of first child 3.9 7.0 13.4 2.2 1.0 3.6 0.4 2.8 2.7 2.9 3.7
Peak expiratory flow (PEF) 0.6 1.4 4.6 -0.7 1.3 -2.1 1.4 -1.0 0.2 -1.0 -0.9
Pulse wave reflection index 0.6 0.7 1.8 -1.3 0.3 -0.3 0.6 -1.4 0.1 -0.9 -0.8
Ever highly irritable/argumentative for 2 days 0.2 0.3 0.9 0.3 0.9 -0.6 -0.1 0.3 -0.9 0.3 0.2
Loud music exposure frequency 0.2 0.2 0.5 0.2 0.7 0.4 0.3 -0.0 -0.7 0.5 0.3
Qualifications: O levels/GCSEs or equivalent 0.4 0.6 2.0 -1.0 -0.7 -0.4 -0.4 -0.4 0.1 -1.4 -1.0
Mouth/teeth dental problems: Bleeding gums 3.3 4.2 7.8 -2.2 -1.5 -1.6 -0.7 -2.8 -2.2 -2.3 -2.4
Blood clot in the leg (DVT) 2.2 2.8 7.3 -2.2 0.3 -1.6 0.7 -2.0 -0.5 -2.7 -1.8
Medication: Paracetamol 0.3 0.5 1.3 -0.7 0.7 1.1 1.1 -0.2 0.3 -0.6 0.2
Headache pain in last month 0.1 0.2 0.4 -0.5 -0.6 -0.3 -0.1 -0.6 -0.4 -0.5 -0.4
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 1.0 -1.0 0.2 0.2 0.7 -0.3 -0.2 -0.7 -0.0
Glaucoma (self-reported) 1.1 1.3 3.7 1.9 -0.7 1.9 -1.1 0.6 -0.3 1.1 0.2
Gout (self-reported) 1.0 1.4 3.6 1.7 0.8 0.9 0.6 0.7 1.9 1.4 1.0
Hypothyroidism/myxoedema (self-reported) 0.3 0.5 1.9 1.2 0.5 0.0 0.2 0.5 0.3 1.4 0.2
Medication: Amlodipine 0.6 0.8 1.7 -0.7 0.6 -1.3 0.2 -1.0 -0.5 -1.2 -1.0
Medication: Ventolin 100micrograms inhaler 3.8 4.9 9.5 -2.9 1.3 -2.5 2.0 -2.2 0.4 -3.1 -1.9
Birth weight 2.2 4.9 10.0 1.9 1.8 2.9 -0.2 2.5 1.2 2.4 3.2
Chronic bronchitis/emphysema (mother) 0.1 0.2 0.4 -0.7 -0.4 -0.1 -0.3 -0.3 -0.7 -0.2 -0.1
High blood pressure (siblings) 0.4 0.6 1.1 0.9 -0.3 -0.5 -0.9 1.1 -0.8 0.9 0.6
Forced vital capacity (FVC), Best measure 0.2 0.8 2.4 0.1 -0.9 -1.2 -0.1 -1.6 -0.1 -0.1 -1.4
Body fat percentage 0.5 1.9 4.3 -1.1 2.1 -1.9 2.1 -0.5 -0.9 -0.7 -0.4
Leg fat percentage (right) 0.4 1.3 4.5 -0.8 1.4 -2.1 1.5 -0.4 -0.6 -0.4 -0.6
Arm fat-free mass (right) 0.5 2.7 12.9 -0.5 0.3 -3.6 0.9 -2.3 -0.1 -0.6 -1.3
Exposure to tobacco smoke outside home 0.7 0.9 3.3 -1.1 0.5 1.8 1.0 -0.9 -0.1 -0.8 -0.6
Comparative body size at age 10 1.1 3.0 5.8 2.2 -0.1 1.9 -1.1 2.3 -0.5 2.4 1.8
Number of full brothers 1.6 2.0 6.3 -1.2 1.7 -2.5 0.6 -0.8 -1.9 -1.0 -0.3
Worry too long after embarrassment 1.7 2.9 10.5 1.5 -2.1 3.2 -2.1 0.3 0.9 0.6 -0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.9 1.1 5.4 -0.5 -0.1 -2.3 -0.9 -0.2 -1.5 -0.4 -0.5
Wheeze or whistling in the chest in last year 1.5 2.7 5.8 -2.2 2.1 -1.5 2.4 -1.0 -0.3 -1.7 -0.5
Number of children fathered 3.4 3.9 9.0 -2.6 1.7 -0.6 3.0 -1.8 0.4 -2.2 -1.9
Reason for reducing amount of alcohol drunk: Health precaution 1.0 1.2 2.4 0.8 -1.2 -0.9 -1.1 1.4 0.2 0.9 1.5
Age at first live birth 0.1 0.1 0.6 -0.2 0.2 -0.8 0.4 0.3 0.4 -0.2 0.3
Pulse wave peak to peak time 1.1 1.3 3.8 1.2 0.4 0.5 -0.3 1.6 -0.9 1.1 1.9
Health satisfaction 1.2 1.5 4.0 -1.0 1.7 -1.1 2.0 -0.3 -1.1 -0.8 -0.9
Shortness of breath walking on level ground 2.8 3.3 5.1 -1.5 1.0 -2.1 1.7 -2.1 -2.3 -1.4 -2.0
Qualifications: College or University degree 0.2 0.6 3.1 -0.1 0.5 -1.8 -0.2 -0.4 -0.9 -0.3 -0.1
Eye problems/disorders: None of the above 0.5 0.5 1.1 -1.0 0.0 -1.0 -0.0 -1.0 -0.9 -0.5 -0.4
Mouth/teeth dental problems: Loose teeth 0.5 0.6 1.3 0.6 -0.7 1.0 -0.9 0.2 1.1 1.0 0.2
Emphysema/chronic bronchitis 0.3 0.3 1.0 -0.5 0.0 -1.0 0.8 -0.1 -0.7 -0.4 -0.2
Medication for pain relief, constipation, heartburn 0.6 1.1 2.9 1.1 -1.7 0.5 -1.6 0.1 0.2 1.2 -0.0
Neck or shoulder pain in last month 0.2 0.3 0.5 0.6 -0.2 0.6 0.2 0.7 0.3 0.7 0.6
Medication: Blood pressure 0.4 0.6 1.2 1.0 0.1 0.9 -0.6 1.1 0.1 0.9 0.8
Angina (self-reported) 0.3 0.4 1.1 0.2 -0.5 -0.2 -0.8 1.1 -0.7 0.2 0.7
Migraine (self-reported) 0.6 0.8 2.4 0.4 -1.3 -0.0 -1.5 -0.9 -0.7 0.1 -0.7
Medication: Ibuprofen 1.3 1.5 3.4 -1.1 -0.9 -0.7 0.0 -1.6 0.6 -1.9 -1.8
Medication: Allopurinol 1.7 2.2 4.1 1.7 1.0 1.2 0.5 1.4 2.0 1.7 1.8
Medication: Omeprazole 1.3 1.6 3.5 1.6 1.4 -0.4 0.8 1.5 0.4 1.9 1.3
Medication: Seretide 50 evohaler 2.0 2.4 4.7 -1.9 0.3 -1.6 0.4 -1.8 -1.2 -2.2 -1.6
Mean time to correctly identify matches 0.4 0.8 2.6 -0.1 -0.6 -1.6 -1.1 -0.6 -1.1 -0.7 -0.4
Heart disease (mother) 0.1 0.2 0.4 0.3 0.6 -0.4 0.5 0.6 -0.1 0.2 -0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.9 1.0 2.4 -0.8 0.7 -1.0 0.9 -1.6 -0.3 -1.0 -1.3
Whole body fat mass 0.5 1.9 4.7 -0.8 2.1 -2.2 2.1 -0.8 -0.4 -0.4 -0.3
Leg fat mass (right) 0.4 1.6 5.1 -0.8 1.5 -2.3 1.8 -0.9 -0.3 -0.4 -0.6
Arm predicted mass (right) 0.6 2.9 13.0 -0.7 0.7 -3.6 1.4 -2.3 -0.1 -0.6 -1.4
Pulse rate, automated reading 0.5 1.7 5.3 0.4 -2.3 2.0 -1.7 0.1 0.6 0.1 -1.0
Alcohol intake frequency. 0.4 1.0 2.5 0.4 0.8 0.9 -0.4 1.6 0.8 1.0 1.5
Comparative height size at age 10 0.2 1.2 4.0 -0.7 0.8 0.4 1.9 -0.8 2.0 -0.5 0.1
Number of full sisters 0.4 0.5 3.1 0.0 0.0 -1.8 -0.1 0.2 -0.5 -0.0 -0.5
Suffer from ‘nerves’ 1.2 1.9 6.4 -1.3 2.5 0.9 1.6 -0.2 1.8 -0.7 0.2
Overall health rating 0.2 0.5 1.9 -0.1 1.4 -0.2 0.5 0.8 0.2 0.2 1.0
Chest pain or discomfort 0.2 0.3 1.0 -0.2 -0.3 -1.0 -0.2 -0.1 -0.3 -0.4 -0.8
Had major operations 0.4 0.5 1.0 -1.0 0.4 -0.7 0.3 -0.6 -0.4 -0.9 -0.8
Age at last live birth 1.0 1.5 2.4 1.5 -0.5 0.2 0.2 1.6 1.6 1.6 1.6
Family relationship satisfaction 1.7 2.1 4.2 -1.2 -0.3 -1.8 0.3 -1.8 -2.1 -1.5 -1.6
Leg pain on walking 1.0 1.2 3.3 -1.0 -0.7 -1.2 1.0 -1.1 -0.0 -1.2 -1.8
Qualifications: NVQ or HND or HNC or equivalent 0.9 1.1 5.8 0.9 -2.4 -0.2 -1.2 0.2 -0.6 0.5 0.1
Commuting to job workplace: Car/motor vehicle 1.2 1.4 2.6 -1.0 1.1 -1.6 1.0 -0.8 -1.0 -1.3 -1.4
Illness, injury, bereavement, stress in last 2 years 0.9 1.1 4.0 0.8 -2.0 0.7 -1.7 -0.1 -0.8 0.4 -0.0
Medication: Aspirin 0.2 0.3 0.9 -0.7 0.7 -0.0 0.2 0.3 -0.9 -0.7 0.3
Supplements: Vitamin C 1.8 2.1 6.2 -0.7 -1.0 -1.2 -0.1 -2.5 -0.3 -1.6 -2.3
Knee pain experienced in last month 1.0 1.5 3.5 -1.2 0.8 -1.9 1.3 -1.2 0.0 -1.2 -1.3
Hypertension (Self-reported) 0.1 0.2 0.4 -0.5 0.2 0.3 0.4 -0.1 0.2 -0.5 -0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.3 0.9 -0.5 0.4 -0.9 -0.0 -0.2 -0.9 -0.3 0.1
Illnesses of father: Heart disease 0.4 0.6 1.8 -0.7 0.6 -1.3 0.8 0.2 -0.3 -0.5 -1.1
Illnesses of siblings: Diabetes 2.9 3.6 7.7 -1.5 -1.1 -2.0 -1.1 -2.2 -2.2 -1.7 -2.8
Smoking status: Previous 0.7 1.0 2.5 -0.0 0.4 1.1 1.2 -0.9 1.5 -0.4 -1.6
Forced expiratory volume in 1-second (FEV1), predicted 0.5 0.9 2.3 -1.4 0.6 0.6 1.0 -1.5 -0.0 -1.0 -0.9
Whole body fat-free mass 0.2 1.2 5.8 0.2 0.9 -2.4 0.9 -1.4 0.3 0.3 -0.4
Leg fat-free mass (right) 0.2 0.8 3.3 0.3 1.2 -1.8 0.9 -0.8 0.1 0.6 0.4
Arm fat percentage (left) 0.3 1.3 3.9 -0.3 2.0 -1.8 1.6 0.5 -0.7 0.4 0.4
Average weekly red wine intake 0.4 0.5 1.7 -0.4 0.0 -1.3 -0.4 -0.7 -0.5 -0.6 -1.1
Handedness (chirality/laterality): Left-handed 0.5 0.6 2.0 0.7 0.1 1.4 -1.0 0.5 -0.3 0.9 0.7
Mood swings 0.3 0.6 1.8 -0.6 -0.9 0.3 -0.7 -1.4 0.2 -0.7 -1.0
Loneliness, isolation 0.4 0.6 1.6 1.0 -0.9 0.3 -1.3 -0.8 -0.1 0.8 -0.3
Long-standing illness, disability or infirmity 0.2 0.2 1.8 0.2 -0.2 -0.2 -0.1 -0.1 1.3 0.0 0.0
Ever had bowel cancer screening 0.2 0.3 0.8 -0.6 0.5 -0.7 0.9 0.2 -0.5 -0.2 0.2
Diabetes diagnosed by doctor 0.2 0.3 1.5 0.1 0.0 -0.5 -0.4 -0.2 -1.2 -0.1 -0.6
Ever had stillbirth, spontaneous miscarriage or termination 0.8 0.9 3.2 -0.8 0.9 -1.8 1.0 0.1 0.0 -1.1 -0.6
Friendships satisfaction 0.5 0.7 2.8 -0.2 1.3 -0.4 0.3 -0.5 -1.7 0.1 -0.4
Qualifications: nursing, teaching 0.6 1.0 3.1 1.1 -1.1 0.4 -1.8 0.9 -0.1 1.3 0.4
Commuting to job workplace: Walk 1.3 1.4 5.2 0.6 -2.2 0.6 -2.3 -0.2 -0.7 0.2 -0.2
Eye problems/disorders: Cataract 1.2 1.4 3.9 -1.3 0.2 0.8 2.0 -0.8 1.1 -1.2 -1.3
Mouth/teeth dental problems: Mouth ulcers 0.4 0.7 1.3 1.1 -0.5 0.2 0.6 -0.9 1.0 0.9 -1.1
Medication for cholesterol 0.6 0.8 1.7 0.9 -0.7 0.8 -1.3 0.8 0.2 1.2 0.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.2 1.4 3.5 -1.4 0.8 -0.3 1.9 -0.2 1.6 -1.3 -0.6
Back pain experienced in last month 0.5 0.8 1.6 1.2 0.3 1.3 -0.1 0.8 1.0 0.8 0.6
Mineral and other dietary supplements 1.0 1.4 3.3 -1.6 1.8 -1.7 1.0 -0.0 -0.6 -0.9 0.1
Breast cancer (self-reported) 0.7 0.8 1.6 1.1 -0.6 -0.7 -1.3 0.9 -0.2 0.9 0.9
Asthma (self-reported) 1.7 3.4 9.5 -1.7 1.8 -3.1 1.8 -1.6 -0.3 -2.2 -0.9
Osteoporosis (self-reported) 0.8 1.0 2.9 0.6 1.1 0.7 0.9 0.5 1.7 0.7 1.3
Osteoarthritis (self-reported) 0.6 0.7 1.5 -1.2 1.2 -0.4 1.2 -0.3 0.2 -1.1 -0.0
Medication: Aspirin 0.6 0.8 2.1 -1.4 0.8 -0.4 0.3 -0.3 -1.2 -1.3 -0.2
Medication: Gliclazide 0.2 0.3 0.9 0.6 -1.0 -0.1 -0.7 0.3 0.2 0.4 -0.1
Illnesses of father: None of the above (group 1) 3.1 3.9 6.5 2.2 -1.8 2.5 -2.1 1.6 0.8 2.3 1.8
Smoking status: Current 0.7 1.1 2.5 -1.5 0.9 -1.2 1.1 -0.6 -1.6 -0.5 0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.2 2.7 1.2 -0.7 -1.6 -1.1 1.0 -0.5 1.3 0.8
Whole body water mass 0.2 1.2 6.2 0.3 0.8 -2.5 0.8 -1.4 0.3 0.3 -0.3
Leg predicted mass (right) 0.2 0.9 3.9 0.3 1.2 -2.0 0.8 -0.8 0.1 0.5 0.4
Arm fat mass (left) 0.3 1.4 4.7 -0.0 1.9 -2.2 1.6 0.0 -0.5 0.5 0.3
Number of self-reported non-cancer illnesses 0.5 0.8 1.8 0.6 1.2 -0.2 1.1 1.1 0.2 0.7 1.3
Average weekly champagne plus white wine intake 0.8 1.0 3.1 -1.3 1.1 -1.8 0.6 -0.1 -0.9 -1.1 -0.1
Miserableness 0.7 1.3 3.3 0.4 -1.3 -0.1 -0.1 -1.5 1.7 -0.2 -1.8
Guilty feelings 2.4 3.6 9.1 2.1 -3.0 2.2 -2.1 0.4 2.1 1.4 0.2
Wears glasses or contact lenses 0.4 0.5 1.6 -0.3 1.2 0.5 1.3 0.4 0.6 -0.1 0.2
Ever taken oral contraceptive pill 0.5 0.6 4.1 -0.3 -0.1 -2.0 0.1 -0.2 -0.7 -0.2 -0.1
Hearing aid user 1.0 1.1 4.1 -0.3 0.2 -1.4 -0.4 -1.1 -2.0 -0.3 -1.2
Mother’s age at death 1.0 1.2 3.5 0.4 -1.9 -0.8 -1.4 -0.9 0.1 -0.4 -1.5
Financial situation satisfaction 1.3 1.7 2.5 -1.6 1.5 -1.0 1.0 -1.2 -1.1 -1.6 -1.3
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.4 -0.3 0.1 0.2 -0.4 0.1 -0.7 -0.4 0.4
Commuting to job workplace: Public transport 0.5 0.6 1.5 0.8 -0.2 0.5 -0.7 0.5 0.9 1.0 1.2
Eye problems/disorders: Glaucoma 0.9 1.0 3.0 1.5 -0.8 1.7 -1.2 0.7 -0.0 0.7 0.0
Medication: Blood pressure 0.7 1.3 2.7 -1.6 -0.3 -0.6 0.2 -1.1 -0.9 -1.6 -1.6
Pain type(s) experienced in last month: Hip pain 0.3 0.4 1.8 0.0 -0.2 1.3 -0.2 -0.3 -0.4 -0.3 -1.0
Supplements: Fish oil (including cod liver oil) 0.5 0.7 2.6 0.6 -1.6 1.1 -0.3 -0.4 0.7 0.1 -0.7
High cholesterol (Self-reported) 0.2 0.3 1.0 0.2 0.1 -0.4 0.4 -0.6 -1.0 -0.4 -0.8
Medication: Bendroflumethiazide 0.6 0.8 3.8 -0.5 -0.5 0.2 0.3 -1.2 -0.3 -0.8 -2.0
Medication: Paracetamol 0.5 0.8 2.6 -1.4 0.2 -0.3 0.5 -1.2 -0.4 -1.6 -0.6
Medication: Lisinopril 0.6 0.7 2.0 -0.9 -0.7 0.0 -0.3 -1.0 -0.3 -1.1 -1.4
Medication: Atorvastatin 0.4 0.5 1.0 -0.7 0.8 -0.2 0.2 -0.5 -0.7 -1.0 -0.7
Illnesses of father: High blood pressure 1.3 1.6 3.8 -1.0 1.2 -2.0 1.4 -1.1 0.1 -1.2 -1.3
Alcohol drinker status: Never 1.6 1.9 3.5 1.7 -0.6 1.4 -0.3 1.5 1.5 1.9 1.5
Ever smoked 0.3 0.6 1.6 0.5 0.7 0.9 1.3 -0.4 1.1 0.5 -0.0
Basal metabolic rate 0.2 1.1 5.6 0.2 0.9 -2.4 0.9 -1.2 0.2 0.4 -0.2
Leg fat percentage (left) 0.3 1.1 4.8 -0.5 1.2 -2.2 1.2 -0.3 -0.8 -0.1 -0.4
Arm fat-free mass (left) 0.3 1.5 9.1 0.5 0.3 -3.0 0.3 -1.4 -0.1 0.4 -0.5
Number of operations (self-reported) 1.0 1.5 3.9 -1.6 -0.0 -1.8 0.6 -0.5 -0.0 -2.0 -1.3
Average weekly beer plus cider intake 0.3 0.5 3.0 -0.3 -1.7 -0.5 -0.2 -0.2 0.3 -0.1 -0.6
Irritability 0.5 0.9 3.1 -0.5 0.3 -1.3 0.5 -1.8 -0.6 -0.7 -0.9
Risk taking 1.1 1.6 10.6 -0.7 0.7 -3.3 0.0 -0.0 -0.9 -0.5 -0.3
Ever had prostate specific antigen (PSA) test 2.6 3.0 5.8 -1.4 -0.8 -2.4 -0.6 -2.4 -1.7 -1.7 -2.0
Fractured/broken bones in last 5 years 0.4 0.5 2.4 -0.5 -0.9 -0.0 0.3 0.5 1.6 0.4 0.4
Age started oral contraceptive pill 1.7 2.2 6.1 2.5 -1.9 0.2 -1.9 0.5 -0.6 1.8 0.2
Diastolic blood pressure, automated reading 0.1 0.3 1.0 -0.2 0.6 -0.5 -0.4 -0.1 -1.0 0.0 -0.9
Ever depressed for a whole week 1.4 1.7 6.0 0.6 -0.8 -1.8 -1.7 -0.6 -2.5 0.3 -0.5
Unable to work because of sickness or disability 0.4 0.5 1.7 -0.2 0.7 -0.5 -0.1 1.3 -0.1 0.5 1.1
Commuting to job workplace: Cycle 0.9 1.1 2.9 1.4 -0.8 -0.4 -1.2 0.7 -1.7 1.2 -0.0
Myopia 0.4 0.6 1.1 -0.5 -0.4 -1.0 -1.0 -0.6 -0.9 -0.1 1.0
Vascular/heart problems diagnosed by doctor 0.3 0.7 1.5 1.2 0.1 0.4 0.1 0.9 0.3 1.2 1.2
Cholesterol lowering medication 0.4 0.7 1.4 -0.5 0.2 -1.2 0.8 -0.7 -0.4 -1.1 -1.0
Medication: Omeprazole (e.g. Zanprol) 0.7 0.9 2.0 0.5 1.4 -1.4 0.9 0.8 -0.3 0.9 0.5
Pain experienced in last month 0.8 1.4 2.9 1.0 -1.2 0.6 -1.7 1.0 0.3 1.2 1.5
Supplements: Calcium 0.5 0.5 2.1 -0.6 0.3 0.6 1.4 -0.8 0.6 -0.4 -0.3
Basal cell carcinoma (self-reported) 0.7 0.8 1.8 -1.2 0.4 -0.7 1.3 -0.9 1.0 -0.8 -0.6
Heart attack/myocardial infarction (self-reported) 0.6 0.8 2.3 0.5 -0.3 -0.3 -0.9 1.5 0.8 1.0 1.1
Deep venous thrombosis (DVT) (self-reported) 2.4 3.1 7.9 -2.3 -0.0 -1.6 0.5 -2.0 -0.8 -2.8 -2.0
Heart disease (siblings) 0.2 0.3 1.0 -0.1 -0.6 -0.4 -0.5 -0.1 -0.6 -0.2 -1.0
Alcohol drinker status: Previous 0.3 0.4 1.0 -1.0 0.5 -0.4 0.1 0.3 -1.0 -0.4 0.2
Pack years of smoking 0.8 1.1 3.3 -0.6 1.8 -0.8 1.1 1.0 -0.8 0.3 1.2
Impedance of whole body 0.3 1.6 5.4 -1.7 0.2 2.3 0.8 -0.4 -0.5 -1.7 -0.6
Leg fat mass (left) 0.3 1.3 5.0 -0.6 1.2 -2.2 1.5 -0.9 -0.6 -0.3 -0.7
Arm predicted mass (left) 0.3 1.4 8.7 0.4 0.3 -3.0 0.3 -1.4 -0.1 0.3 -0.6