Hub : Genes

EXOSC1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0570	0.0240	4.6e-03	0.053	0.000	0.020	0.015	0.032	4.6e-07	2.8e-01	1.4e-03	0.0058	6.9e-05
2	GTEx	Muscle Skeletal	0.0559	0.0250	8.3e-03	-0.002	NA	-0.001	NA	0.015	7.2e-01	NA	3.8e-01	NA	1.1e-02
3	ROSMAP	Brain Pre-frontal Cortex	0.0406	0.0171	3.3e-03	0.008	0.013	0.013	0.010	0.013	3.1e-02	7.7e-03	6.7e-03	0.0170	7.6e-03
4	YFS	Blood	0.0171	0.0069	1.2e-03	0.021	0.005	0.014	0.007	0.017	1.5e-07	9.3e-03	1.9e-05	0.0019	2.7e-06
5	TCGA	Brain Lower Grade Glioma	0.1354	0.0501	3.3e-06	0.044	0.050	0.047	NA	0.055	7.9e-06	2.4e-06	4.6e-06	NA	7.3e-07
6	TCGA	Liver Hepatocellular Carcinoma	0.2150	0.0840	1.6e-04	0.021	0.061	0.066	NA	0.025	3.3e-02	7.7e-04	4.8e-04	NA	2.3e-02
7	TCGA	Prostate Adenocarcinoma	0.0703	0.0378	5.0e-03	0.039	0.021	0.020	NA	0.023	5.5e-05	2.3e-03	3.2e-03	NA	1.5e-03
8	TCGA	Thyroid Carcinoma	0.0840	0.0400	1.5e-03	0.007	0.020	0.006	NA	0.015	6.9e-02	4.5e-03	7.4e-02	NA	1.3e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8
Bipolar Disorder (2018)	2.7	4.2	10.4	-0.8	-1.1	-3.2	-1.0	-2.5	-2.8	-1.7	-2.0
Bipolar Disorder or Schizophrenia	1.8	4.4	11.1	-1.1	-1.7	-2.9	-1.4	-1.9	-3.3	-1.5	-1.9
Depressed Affect (Nagel 2018)	0.5	1.0	2.7	-0.2	-0.5	0.2	0.2	-1.7	1.4	-0.4	-1.6
Depression (Nagel 2018)	0.1	0.1	0.2	-0.1	-0.1	0.4	-0.4	-0.3	0.3	0.3	0.2
Intelligence (Savage-Jansen 2018)	1.6	5.0	12.6	-0.7	-0.7	-3.6	-0.2	-2.8	-2.2	-1.5	-3.4
Neuroticism (Nagel 2018)	1.1	2.6	9.1	0.7	-1.5	3.0	-0.6	-0.7	2.6	0.5	-0.9
Schizophrenia (2018)	0.6	1.2	4.1	-0.7	-1.3	-1.1	-1.0	-0.4	-2.0	-0.6	-0.9
Schizophrenia vs Biploar Disorder	0.9	1.2	3.8	0.4	0.2	1.2	-0.7	1.4	1.9	0.9	1.1
Worry (Nagel 2018)	1.0	2.1	10.1	-0.1	-0.7	3.2	-0.1	-0.2	2.5	0.1	-0.6
Alzheimer’s Disease (in mother)	1.8	2.1	11.4	0.4	-3.4	-1.0	-1.3	-0.9	0.2	0.1	-1.3
Alzheimer’s Disease (in father)	2.5	2.7	13.4	-1.3	-0.1	-3.7	0.3	-1.4	-0.7	-1.5	-1.4
Alzheimer’s Disease (including proxy)	2.2	3.3	9.0	0.0	-3.0	-2.9	-1.6	-1.5	-0.8	-0.4	-1.8
Crohns Disease (2017)	0.9	2.1	6.8	-0.1	-2.2	1.1	-2.6	-0.4	-1.6	-0.5	-0.8
Irritable Bowel Disease (IBD)	0.7	1.8	7.8	0.3	-2.3	0.6	-2.8	0.2	-0.8	-0.3	-0.2
Ulcerative Colitis (UC)	0.3	0.6	2.1	-0.2	-1.3	-0.1	-1.4	-0.1	0.3	-0.8	-0.1
Major Depression (MDD)	4.0	4.9	12.1	-1.7	1.3	-3.5	1.0	-2.5	-2.6	-2.1	-2.0
Reaction Time	0.5	0.9	1.8	-0.0	-1.0	-1.3	-1.4	-0.5	-1.3	-0.9	-0.4
Verbal and Numeric Reasoning (VNR)	2.5	5.9	15.1	-1.5	-0.3	-3.9	-0.3	-2.7	-3.1	-2.0	-3.0
Breast Cancer	0.2	0.5	2.1	-0.0	0.3	0.9	1.1	0.1	1.5	0.0	-0.0
Ovarian Cancer	0.3	0.3	1.5	0.5	0.3	0.2	-0.4	0.2	-1.2	0.6	0.5
Prostate Cancer	0.4	0.6	2.3	0.4	-1.2	-0.1	0.0	-0.5	1.5	-0.1	-0.7
Age at First Birth	0.7	1.0	2.2	-1.3	-0.8	-0.5	0.8	-0.8	0.8	-1.3	-1.5
Bipolar Disorder (2011)	3.3	3.2	5.6	-0.3	-1.6	-1.8	-1.6	-2.4	-2.3	-1.4	-2.0
Body Mass Index (BMI) (2010)	1.5	2.0	3.9	-1.9	1.7	-1.8	2.0	-1.1	-0.3	-1.1	0.0
Coronary Artery Disease (CAD)	0.8	0.9	4.3	-1.0	0.4	-2.1	0.6	-0.4	-0.9	-0.6	0.1
Crohns Disease (2012)	0.3	0.4	1.3	0.3	-0.6	0.4	-1.1	0.8	-0.8	0.2	0.5
Mean Putamen Volume	0.4	0.4	1.2	1.1	-0.9	0.4	-0.8	-0.1	-0.3	0.6	-0.2
Fasting Glucose	3.5	4.2	8.8	-2.1	1.3	-3.0	0.9	-2.0	-2.5	-2.4	-1.4
HbA1C	0.2	0.2	0.6	0.3	-0.1	-0.7	0.0	0.8	-0.3	0.6	0.5
HDL Cholesterol	0.2	0.3	0.7	-0.2	0.5	0.5	0.3	0.7	-0.6	0.3	0.9
LDL Cholesterol	1.2	2.0	4.4	-0.7	-1.4	-1.3	-0.8	-2.0	-1.0	-1.2	-2.1
Lupus	0.4	0.6	1.4	-0.2	-1.0	-0.5	-0.8	-0.9	-1.2	-0.2	-1.0
Neuroticism (2016)	0.8	1.2	3.2	0.5	-1.0	1.8	-0.8	-0.3	1.8	-0.0	-0.9
Primary Biliary Cirrhosis	1.0	1.4	5.0	1.2	-1.1	0.7	-2.2	-0.3	-1.4	0.9	0.4
Rheumatoid Arthritis	0.8	1.1	5.3	-0.3	-0.7	2.3	0.1	0.2	1.7	-0.4	0.2
Schizophrenia (2014)	0.4	0.8	2.8	-0.4	-0.8	-1.2	-0.7	-0.3	-1.7	-0.3	-0.6
Triglycerides	2.0	3.2	8.4	-1.5	-1.3	-1.5	-0.1	-2.4	-1.4	-1.8	-2.9
Type 2 Diabetes (T2D) (2012)	2.0	2.3	3.8	-1.2	-1.9	-1.6	-1.2	-1.8	-0.7	-1.5	-1.9
Ulcerative Colitis	0.7	1.0	2.6	0.7	0.0	0.1	-0.2	1.5	1.6	0.3	1.5
Blood Eosinophil Count	1.1	8.5	27.5	0.9	2.1	5.2	1.6	2.3	4.1	1.6	2.8
Blood Platelet Count	0.6	7.3	20.9	-0.7	4.6	0.9	4.0	1.8	3.1	0.3	2.7
Blood Red Count	0.2	2.4	7.0	-1.0	-0.2	-2.6	0.8	-1.8	0.4	-1.4	-2.2
Blood White Count	10.9	80.5	243.4	3.7	6.0	15.6	6.5	7.7	11.9	5.6	8.8
Heel T-Score	0.2	1.5	4.4	-0.2	1.8	0.0	0.7	2.1	-1.6	0.5	1.1
BMI	0.5	2.8	16.2	-0.4	0.8	-4.0	1.1	-1.1	-1.3	-0.3	-1.1
Height	0.1	2.1	6.4	-1.2	-0.6	0.9	1.4	-2.5	1.7	-1.5	-1.0
Waist Hip Ratio (WHR)	0.1	0.5	2.5	1.6	0.4	0.2	-0.0	0.3	0.4	1.1	0.3
Systolic Blood Pressure	0.1	0.4	0.8	-0.9	0.7	-0.5	0.4	0.3	-0.2	-0.9	-0.7
Smoking Status	0.2	0.5	1.3	-0.9	0.2	-0.3	0.7	-1.1	-0.1	-0.7	-0.8
Allergy or Eczema	1.0	2.6	7.2	0.4	2.3	-0.9	1.3	1.7	1.1	1.2	2.7
Cardiovascular Disease	0.4	1.2	2.3	-1.3	1.5	-1.0	1.3	-1.0	-0.5	-1.1	-0.9
Hypothyroidism (self reported)	0.3	0.6	2.0	1.1	0.1	-0.1	-0.4	0.9	-0.1	1.4	0.7
Respiratory disease	2.4	5.4	10.0	-2.8	2.4	-3.2	2.9	-1.9	-0.5	-2.6	-0.9
Type 2 Diabetes (T2D) (2018)	0.3	0.6	2.4	-0.2	-0.0	-1.4	-0.4	0.2	-1.5	0.2	-0.1
Lung FEV1/FVC ratio	0.1	0.6	1.5	0.8	0.8	-1.2	0.2	0.8	-0.5	0.7	0.9
Lung FVC	0.4	2.1	6.1	-0.1	-0.9	-2.5	-1.1	-0.8	-2.3	0.0	-1.7
Neuroticism	0.8	1.8	6.5	0.5	-1.3	2.5	-1.0	-1.2	1.5	0.0	-1.4
Chronotype (morning person)	0.7	1.6	3.6	0.9	1.8	1.9	0.0	0.9	-0.8	1.0	1.7
Hair Pigment	0.0	1.1	5.4	0.3	-0.5	1.2	0.6	0.7	2.3	0.7	0.2
Tanning	0.0	0.1	0.2	-0.0	0.2	-0.5	0.1	0.3	0.4	0.1	0.3
Hand grip strength (left)	0.8	2.1	10.1	-0.5	-0.7	-3.2	-0.1	-1.2	-1.7	-0.1	-1.3
Number of treatments/medications taken	1.0	1.8	6.4	-0.9	2.1	0.5	2.5	0.2	1.4	-0.5	0.6
Average weekly spirits intake	0.4	0.4	1.5	0.2	-0.5	0.5	0.1	1.2	1.0	0.4	0.5
Sensitivity / hurt feelings	1.4	2.4	4.3	0.2	-2.1	2.1	-1.5	-2.1	-0.6	-0.2	-2.0
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.0	-0.2	-0.0	0.3	-0.3	-1.0	-0.5	-0.2	-0.8
Hearing difficulty/problems: Yes	0.8	1.2	3.8	-0.1	-0.5	-1.7	-0.4	-1.2	-1.9	-0.7	-0.9
Relative age of first facial hair	1.5	3.0	7.2	-1.9	2.7	-2.2	2.1	-0.8	-1.5	-1.0	-0.0
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	2.9	0.3	-1.3	-1.7	-0.2	0.1	0.5	0.6	0.3
Ever used hormone-replacement therapy (HRT)	1.1	1.4	4.5	-0.6	1.2	-1.1	2.1	-0.8	-0.4	-0.7	-1.5
Ever had hysterectomy (womb removed)	1.0	1.1	2.3	-1.5	0.8	-0.7	1.5	-0.7	0.0	-1.2	-1.3
Systolic blood pressure, automated reading	0.0	0.1	0.9	-0.1	0.2	-0.0	-0.1	0.1	-0.1	-0.2	-0.9
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.2	-0.1	-1.0	1.0	-1.1	0.1	-0.3	-0.4	-0.6
Angina	0.4	0.6	1.4	0.5	-0.5	-0.1	-0.9	1.2	-0.8	0.5	0.9
Medication for hormone replacement therapy	1.3	1.4	4.0	-0.8	1.4	-1.0	2.0	-0.7	-0.0	-1.2	-1.2
Vitamin and mineral supplements	0.3	0.5	1.0	0.0	-0.9	-0.9	-0.9	-0.4	-0.4	0.2	-1.0
Supplements: Zinc	0.2	0.2	0.5	-0.6	-0.7	-0.0	0.0	-0.4	-0.0	-0.7	-0.5
Medication: Co-codamol	1.1	1.3	3.5	1.0	0.1	-0.1	0.6	1.9	1.1	1.3	1.6
Medication: Metformin	0.3	0.4	1.0	-0.2	-0.3	-0.8	-0.3	-0.6	-0.9	-0.6	-1.0
Diabetes (father)	0.1	0.1	0.4	-0.1	0.1	-0.3	0.1	-0.3	-0.7	-0.5	-0.5
Diabetes (mother)	1.1	1.4	3.6	1.5	-1.1	-1.9	-1.3	0.5	-1.2	1.0	-0.1
Severe depression (siblings)	1.5	1.7	9.2	-1.1	0.9	-3.0	0.2	-0.5	-1.3	-0.6	-0.2
Pack years adult smoking proportion	1.0	1.6	5.1	-0.9	2.3	-0.9	1.4	1.1	-0.7	0.3	1.5
Impedance of leg (right)	0.4	1.9	4.4	-1.9	-0.3	1.3	0.8	-1.3	-0.5	-2.1	-1.8
Leg fat-free mass (left)	0.2	1.0	3.2	0.2	1.5	-1.8	1.2	-0.8	0.4	0.5	0.4
Trunk fat percentage	0.6	2.3	5.3	-1.4	2.3	-1.8	2.3	-0.8	-1.0	-0.9	-0.4
Hand grip strength (right)	0.8	2.1	11.8	-0.9	-0.1	-3.4	0.7	-1.1	-1.2	-0.3	-1.0
Townsend deprivation index at recruitment	0.1	0.1	0.2	-0.2	-0.1	-0.5	0.1	0.0	0.4	0.0	0.4
Current tobacco smoking	0.9	1.5	3.6	-1.9	0.9	-1.6	1.2	-0.9	-1.3	-1.0	-0.0
Average weekly fortified wine intake	1.0	1.2	2.8	-0.4	0.8	-1.0	0.7	1.2	1.6	0.3	1.7
Maternal smoking around birth	1.1	1.5	3.0	-1.1	0.6	-1.7	-0.7	-1.4	-1.4	-1.5	-0.9
Fed-up feelings	1.3	2.3	7.5	-1.3	-1.2	0.1	-0.2	-2.3	0.4	-1.5	-2.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.1	0.1	-0.2	0.2	0.3	-0.4	-0.2	0.3	0.2	0.1
Relative age voice broke	0.5	0.8	2.4	-0.8	0.3	-0.3	0.6	-1.6	-0.5	-0.9	-1.2
Taking other prescription medications	0.6	0.9	3.5	-0.6	1.8	-0.5	1.9	0.1	0.4	-0.3	0.2
Age when periods started (menarche)	0.8	2.0	4.5	-1.5	-0.5	-0.9	0.1	-1.9	-2.1	-1.7	-1.3
Bilateral oophorectomy (both ovaries removed)	1.5	1.7	5.2	0.0	1.6	-0.5	2.3	0.7	2.3	-0.1	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.4	-0.5	0.8	-1.2	0.6	0.4	-0.5	-0.5	0.0
Tinnitus: Yes, but not now, but have in the past	2.2	2.4	6.5	-1.6	-0.5	-0.1	0.9	-2.1	-0.7	-1.9	-2.5
Qualifications: CSEs or equivalent	1.1	1.5	3.9	0.1	1.9	2.0	0.1	1.3	0.2	0.5	1.6
Serious illness, injury or assault to yourself	0.9	1.1	3.5	-0.6	1.4	-1.9	1.5	0.3	-0.5	-0.3	0.5
High blood pressure	0.2	0.6	1.2	-1.1	0.3	0.0	0.5	-0.8	-0.3	-1.1	-1.1
Hayfever, allergic rhinitis or eczema	1.0	2.2	7.3	-0.3	2.7	-1.7	1.8	0.7	0.7	0.3	1.8
Multivitamins +/- minerals	1.2	1.5	5.4	1.0	0.6	0.8	0.1	1.7	1.1	0.8	2.3
Stomach or abdominal pain in last month	1.6	2.0	4.7	-1.5	1.9	-1.9	2.2	0.6	0.6	-0.6	0.8
Supplements: Glucosamine	0.4	0.5	2.0	0.8	-1.4	-0.0	-0.5	-0.3	0.6	0.7	-0.5
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.6	-0.2	0.8	0.5	0.4	-0.2	0.4	-0.5	-0.2
Medication: Atenolol	2.1	2.6	5.5	1.6	0.8	2.0	-0.7	2.1	0.3	1.8	2.3
Medication: Levothyroxine sodium	0.9	1.5	4.2	1.6	-0.2	1.0	-0.7	1.6	0.5	2.0	1.2
Sitting height	0.2	1.1	4.2	-1.0	0.1	-0.6	0.5	-2.0	0.3	-1.4	-1.0
Chronic bronchitis/emphysema (father)	1.0	1.2	2.5	-1.6	1.5	-0.8	1.0	0.1	-1.0	-1.5	-0.0
High blood pressure (mother)	0.2	0.3	1.4	-0.3	1.2	0.2	0.4	0.0	-0.7	-0.3	-0.6
Body mass index (BMI)	0.3	1.2	5.9	0.4	1.4	-2.4	0.7	0.3	-0.7	0.8	0.3
Impedance of leg (left)	0.4	1.9	4.3	-1.7	-0.8	1.3	0.3	-1.3	-0.9	-2.1	-1.7
Leg predicted mass (left)	0.2	1.0	3.3	0.1	1.4	-1.8	1.2	-0.9	0.3	0.4	0.3
Trunk fat mass	0.5	2.1	5.0	-1.0	2.1	-2.2	2.2	-1.0	-0.5	-0.6	-0.4
Waist circumference	0.2	0.7	1.7	1.1	1.1	-1.3	0.7	-0.2	-0.1	1.0	-0.0
Number of incorrect matches in round	0.2	0.4	1.3	-0.2	0.9	-0.9	1.1	-0.2	-0.0	0.2	0.3
Past tobacco smoking	0.4	0.7	1.6	-0.1	-0.5	-0.9	-1.3	0.9	-0.8	0.0	1.2
Alcohol usually taken with meals	1.9	3.0	6.5	-1.3	-0.4	-2.4	-0.0	-2.4	-0.9	-2.0	-2.5
Nervous feelings	0.9	1.7	7.6	-0.7	0.8	2.8	0.5	-1.0	1.9	-0.6	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.3	1.1	0.2	0.9	-0.4	0.7	0.6	1.1	0.7
Hearing difficulty/problems with background noise	2.0	3.2	5.7	-1.5	-1.0	-2.4	-0.2	-2.4	-1.7	-2.0	-2.1
Hair/balding pattern: Pattern 2	0.2	0.2	0.7	-0.8	-0.1	-0.3	-0.2	-0.4	-0.4	-0.8	-0.3
Had menopause	0.3	0.3	2.0	-0.6	0.2	-0.2	-0.1	0.2	-1.4	-0.3	0.1
Had other major operations	0.5	0.7	1.9	-0.4	-1.4	-1.1	-0.8	-0.4	-0.4	-0.5	-0.8
Forced vital capacity (FVC)	0.3	1.2	3.6	-0.3	-0.6	-1.9	-0.1	-1.7	-0.4	-0.4	-1.6
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.4	-1.1	0.1	-1.2	0.6	-0.1	-0.6	-1.1	-0.2
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.5	0.4	-1.2	-0.8	-1.1	0.0	-1.1	0.5	0.0
Qualifications: None of the above	1.1	2.4	5.2	0.4	1.6	1.7	2.3	0.9	2.0	0.9	1.4
Financial difficulties in last 2 years	0.8	1.1	2.7	0.3	1.5	-0.4	1.1	1.6	0.6	0.8	1.0
Mouth/teeth dental problems	0.2	0.4	1.3	0.2	0.6	-0.2	0.1	1.1	-0.3	-0.1	1.0
Heart attack	0.5	0.6	1.7	0.5	-0.4	-0.4	-0.8	1.3	0.7	0.8	0.9
Allergy	0.9	2.0	5.7	1.1	-2.4	2.1	-1.9	0.1	-0.4	0.7	-0.7
Pain all over the body in last month	0.7	0.8	2.7	0.4	1.3	0.7	0.0	0.9	0.2	0.8	1.6
Diabetes (self-reported)	0.1	0.1	0.7	0.3	0.3	-0.3	-0.3	0.1	-0.8	0.1	0.0
Hayfever/allergic rhinitis (self-reported)	1.1	1.5	4.4	1.3	0.3	0.5	-0.3	2.1	0.8	1.6	1.6
Medication: Ramipril	0.3	0.4	0.9	0.6	-0.6	-0.8	-0.3	-0.3	-1.0	0.6	0.0
Medication: Simvastatin	0.3	0.4	1.6	-0.2	-0.4	-1.3	0.2	-0.5	0.1	-0.5	-0.8
Fluid intelligence score	3.0	6.1	16.3	-1.2	-1.4	-4.0	-1.2	-2.2	-3.8	-1.7	-2.5
Illnesses of siblings	0.5	0.6	1.8	0.6	0.1	1.3	0.1	0.5	1.2	0.6	0.9
Neuroticism score	1.2	2.4	4.6	-0.1	-1.9	1.9	-1.6	-2.1	0.6	-0.8	-2.2
Weight	0.2	1.0	4.7	0.2	1.2	-2.2	1.1	-0.7	-0.0	0.4	-0.0
Impedance of arm (right)	0.5	2.3	14.0	-1.0	1.0	3.7	0.9	0.8	0.2	-0.8	0.6
Arm fat percentage (right)	0.3	1.2	4.0	0.3	2.0	-1.2	1.3	0.9	-0.5	0.8	0.8
Trunk fat-free mass	0.2	1.1	5.6	0.5	0.2	-2.4	0.4	-1.4	0.4	0.4	-0.6
Hip circumference	0.1	0.6	2.3	0.2	1.5	-0.8	1.1	-0.3	-0.1	0.5	0.3
Time employed in main current job	0.4	0.4	1.5	-0.8	0.1	1.2	0.4	-0.1	1.0	-0.4	-0.0
Alcohol intake versus 10 years previously	0.5	0.7	2.1	-0.8	0.2	-0.1	0.4	-1.0	-0.5	-1.3	-1.4
Father’s age at death	0.3	0.4	1.4	-0.3	0.4	-0.1	0.5	-1.2	-0.0	-0.9	-0.9
Worrier / anxious feelings	1.6	3.0	10.1	0.8	-2.4	3.2	-2.5	0.6	0.7	0.7	-0.0
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	1.0	-0.0	-0.3	-0.6	-0.3	-0.9	-1.0	0.0	-1.0
Falls in the last year	0.3	0.3	2.0	-0.4	1.4	-0.3	0.1	-0.1	-0.3	-0.5	0.4
Hair/balding pattern: Pattern 3	1.2	1.8	4.4	1.4	0.0	0.8	-1.7	2.1	-0.2	1.2	1.8
Number of live births	0.5	0.8	2.3	1.0	0.6	0.4	0.8	1.5	0.6	0.8	0.7
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	6.0	-0.4	-0.2	-2.4	-0.0	-1.5	-0.5	-0.4	-1.3
Pulse rate	0.1	0.2	0.7	-0.2	-0.2	-0.6	0.1	0.2	0.3	-0.4	-0.8
Happiness	3.1	3.8	9.2	-1.4	-0.9	-1.0	-0.7	-2.7	-2.4	-1.9	-3.0
Noisy workplace	0.9	1.1	5.8	0.3	-0.7	2.4	-0.6	0.6	0.5	0.8	0.7
Qualifications: A levels/AS levels or equivalent	0.8	1.7	3.5	-0.1	-1.2	-0.8	-1.6	-1.4	-1.6	-1.0	-1.9
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.1	2.6	0.7	1.0	0.8	0.5	1.6	0.2	1.3	1.4
Mouth/teeth dental problems: Dentures	0.5	0.8	2.2	-0.7	1.1	0.6	1.5	0.4	1.4	-0.2	0.5
Asthma	2.0	3.9	9.7	-1.9	1.9	-3.1	1.9	-1.9	-0.4	-2.3	-1.1
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	3.3	-1.1	-0.5	-0.5	0.7	-1.2	0.7	-1.8	-1.7
Medication: Cholesterol lowering	0.1	0.2	0.9	0.4	-0.1	-1.0	-0.5	-0.0	-0.3	0.2	-0.2
Depression (self-reported)	0.2	0.2	0.5	0.1	-0.5	0.5	-0.4	0.5	0.7	0.4	0.6
Medication: Lansoprazole	0.3	0.3	1.2	-1.1	0.7	-0.7	0.6	-0.2	0.1	-0.4	-0.2
Prospective memory result	1.5	1.8	5.7	1.0	0.8	2.4	-0.1	1.3	1.1	1.1	1.8
Lung cancer (father)	0.5	0.6	1.2	0.4	0.8	0.6	0.7	0.7	1.1	0.7	1.1
Illnesses of mother	0.2	0.2	0.6	-0.3	0.0	0.7	0.5	-0.2	0.8	-0.2	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	4.1	-0.3	-0.4	-2.0	0.1	-1.7	-0.7	-0.4	-1.6
Pulse wave Arterial Stiffness index	1.8	2.1	6.0	-1.5	-0.4	-0.8	0.4	-2.1	0.7	-1.5	-2.4
Impedance of arm (left)	0.4	1.7	8.7	-1.4	0.8	3.0	1.0	0.2	-0.2	-1.2	0.2
Arm fat mass (right)	0.3	1.1	3.5	0.1	1.9	-1.8	1.3	0.2	-0.4	0.6	0.5
Trunk predicted mass	0.2	1.1	5.6	0.5	0.3	-2.4	0.5	-1.5	0.4	0.4	-0.6
Standing height	0.1	1.3	5.8	-0.7	0.1	0.0	1.2	-2.4	1.0	-0.9	-1.0
Length of working week for main job	0.3	0.4	1.7	-0.1	-0.6	1.3	0.4	-0.1	0.6	0.5	-0.4
Exposure to tobacco smoke at home	0.8	0.8	1.9	0.7	0.5	0.7	-1.0	1.0	-0.9	1.0	1.4
Breastfed as a baby	1.8	2.2	5.0	2.1	-1.5	0.5	-2.2	1.2	-0.2	1.8	1.2
Tense / ‘highly strung’	0.4	0.6	2.5	-0.1	0.3	1.6	0.6	0.0	1.3	0.0	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.9	2.9	11.5	-0.9	-0.6	-3.4	-1.6	-1.4	-1.9	-1.2	-1.0
Hair/balding pattern: Pattern 4	0.5	1.3	2.9	1.7	-1.7	0.9	-0.9	0.3	0.5	1.5	-0.0
Birth weight of first child	3.9	7.0	13.4	2.2	1.0	3.6	0.4	2.8	2.7	2.9	3.7
Peak expiratory flow (PEF)	0.6	1.4	4.6	-0.7	1.3	-2.1	1.4	-1.0	0.2	-1.0	-0.9
Pulse wave reflection index	0.6	0.7	1.8	-1.3	0.3	-0.3	0.6	-1.4	0.1	-0.9	-0.8
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.9	0.3	0.9	-0.6	-0.1	0.3	-0.9	0.3	0.2
Loud music exposure frequency	0.2	0.2	0.5	0.2	0.7	0.4	0.3	-0.0	-0.7	0.5	0.3
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	2.0	-1.0	-0.7	-0.4	-0.4	-0.4	0.1	-1.4	-1.0
Mouth/teeth dental problems: Bleeding gums	3.3	4.2	7.8	-2.2	-1.5	-1.6	-0.7	-2.8	-2.2	-2.3	-2.4
Blood clot in the leg (DVT)	2.2	2.8	7.3	-2.2	0.3	-1.6	0.7	-2.0	-0.5	-2.7	-1.8
Medication: Paracetamol	0.3	0.5	1.3	-0.7	0.7	1.1	1.1	-0.2	0.3	-0.6	0.2
Headache pain in last month	0.1	0.2	0.4	-0.5	-0.6	-0.3	-0.1	-0.6	-0.4	-0.5	-0.4
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	1.0	-1.0	0.2	0.2	0.7	-0.3	-0.2	-0.7	-0.0
Glaucoma (self-reported)	1.1	1.3	3.7	1.9	-0.7	1.9	-1.1	0.6	-0.3	1.1	0.2
Gout (self-reported)	1.0	1.4	3.6	1.7	0.8	0.9	0.6	0.7	1.9	1.4	1.0
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.9	1.2	0.5	0.0	0.2	0.5	0.3	1.4	0.2
Medication: Amlodipine	0.6	0.8	1.7	-0.7	0.6	-1.3	0.2	-1.0	-0.5	-1.2	-1.0
Medication: Ventolin 100micrograms inhaler	3.8	4.9	9.5	-2.9	1.3	-2.5	2.0	-2.2	0.4	-3.1	-1.9
Birth weight	2.2	4.9	10.0	1.9	1.8	2.9	-0.2	2.5	1.2	2.4	3.2
Chronic bronchitis/emphysema (mother)	0.1	0.2	0.4	-0.7	-0.4	-0.1	-0.3	-0.3	-0.7	-0.2	-0.1
High blood pressure (siblings)	0.4	0.6	1.1	0.9	-0.3	-0.5	-0.9	1.1	-0.8	0.9	0.6
Forced vital capacity (FVC), Best measure	0.2	0.8	2.4	0.1	-0.9	-1.2	-0.1	-1.6	-0.1	-0.1	-1.4
Body fat percentage	0.5	1.9	4.3	-1.1	2.1	-1.9	2.1	-0.5	-0.9	-0.7	-0.4
Leg fat percentage (right)	0.4	1.3	4.5	-0.8	1.4	-2.1	1.5	-0.4	-0.6	-0.4	-0.6
Arm fat-free mass (right)	0.5	2.7	12.9	-0.5	0.3	-3.6	0.9	-2.3	-0.1	-0.6	-1.3
Exposure to tobacco smoke outside home	0.7	0.9	3.3	-1.1	0.5	1.8	1.0	-0.9	-0.1	-0.8	-0.6
Comparative body size at age 10	1.1	3.0	5.8	2.2	-0.1	1.9	-1.1	2.3	-0.5	2.4	1.8
Number of full brothers	1.6	2.0	6.3	-1.2	1.7	-2.5	0.6	-0.8	-1.9	-1.0	-0.3
Worry too long after embarrassment	1.7	2.9	10.5	1.5	-2.1	3.2	-2.1	0.3	0.9	0.6	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.1	5.4	-0.5	-0.1	-2.3	-0.9	-0.2	-1.5	-0.4	-0.5
Wheeze or whistling in the chest in last year	1.5	2.7	5.8	-2.2	2.1	-1.5	2.4	-1.0	-0.3	-1.7	-0.5
Number of children fathered	3.4	3.9	9.0	-2.6	1.7	-0.6	3.0	-1.8	0.4	-2.2	-1.9
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	2.4	0.8	-1.2	-0.9	-1.1	1.4	0.2	0.9	1.5
Age at first live birth	0.1	0.1	0.6	-0.2	0.2	-0.8	0.4	0.3	0.4	-0.2	0.3
Pulse wave peak to peak time	1.1	1.3	3.8	1.2	0.4	0.5	-0.3	1.6	-0.9	1.1	1.9
Health satisfaction	1.2	1.5	4.0	-1.0	1.7	-1.1	2.0	-0.3	-1.1	-0.8	-0.9
Shortness of breath walking on level ground	2.8	3.3	5.1	-1.5	1.0	-2.1	1.7	-2.1	-2.3	-1.4	-2.0
Qualifications: College or University degree	0.2	0.6	3.1	-0.1	0.5	-1.8	-0.2	-0.4	-0.9	-0.3	-0.1
Eye problems/disorders: None of the above	0.5	0.5	1.1	-1.0	0.0	-1.0	-0.0	-1.0	-0.9	-0.5	-0.4
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.3	0.6	-0.7	1.0	-0.9	0.2	1.1	1.0	0.2
Emphysema/chronic bronchitis	0.3	0.3	1.0	-0.5	0.0	-1.0	0.8	-0.1	-0.7	-0.4	-0.2
Medication for pain relief, constipation, heartburn	0.6	1.1	2.9	1.1	-1.7	0.5	-1.6	0.1	0.2	1.2	-0.0
Neck or shoulder pain in last month	0.2	0.3	0.5	0.6	-0.2	0.6	0.2	0.7	0.3	0.7	0.6
Medication: Blood pressure	0.4	0.6	1.2	1.0	0.1	0.9	-0.6	1.1	0.1	0.9	0.8
Angina (self-reported)	0.3	0.4	1.1	0.2	-0.5	-0.2	-0.8	1.1	-0.7	0.2	0.7
Migraine (self-reported)	0.6	0.8	2.4	0.4	-1.3	-0.0	-1.5	-0.9	-0.7	0.1	-0.7
Medication: Ibuprofen	1.3	1.5	3.4	-1.1	-0.9	-0.7	0.0	-1.6	0.6	-1.9	-1.8
Medication: Allopurinol	1.7	2.2	4.1	1.7	1.0	1.2	0.5	1.4	2.0	1.7	1.8
Medication: Omeprazole	1.3	1.6	3.5	1.6	1.4	-0.4	0.8	1.5	0.4	1.9	1.3
Medication: Seretide 50 evohaler	2.0	2.4	4.7	-1.9	0.3	-1.6	0.4	-1.8	-1.2	-2.2	-1.6
Mean time to correctly identify matches	0.4	0.8	2.6	-0.1	-0.6	-1.6	-1.1	-0.6	-1.1	-0.7	-0.4
Heart disease (mother)	0.1	0.2	0.4	0.3	0.6	-0.4	0.5	0.6	-0.1	0.2	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.0	2.4	-0.8	0.7	-1.0	0.9	-1.6	-0.3	-1.0	-1.3
Whole body fat mass	0.5	1.9	4.7	-0.8	2.1	-2.2	2.1	-0.8	-0.4	-0.4	-0.3
Leg fat mass (right)	0.4	1.6	5.1	-0.8	1.5	-2.3	1.8	-0.9	-0.3	-0.4	-0.6
Arm predicted mass (right)	0.6	2.9	13.0	-0.7	0.7	-3.6	1.4	-2.3	-0.1	-0.6	-1.4
Pulse rate, automated reading	0.5	1.7	5.3	0.4	-2.3	2.0	-1.7	0.1	0.6	0.1	-1.0
Alcohol intake frequency.	0.4	1.0	2.5	0.4	0.8	0.9	-0.4	1.6	0.8	1.0	1.5
Comparative height size at age 10	0.2	1.2	4.0	-0.7	0.8	0.4	1.9	-0.8	2.0	-0.5	0.1
Number of full sisters	0.4	0.5	3.1	0.0	0.0	-1.8	-0.1	0.2	-0.5	-0.0	-0.5
Suffer from ‘nerves’	1.2	1.9	6.4	-1.3	2.5	0.9	1.6	-0.2	1.8	-0.7	0.2
Overall health rating	0.2	0.5	1.9	-0.1	1.4	-0.2	0.5	0.8	0.2	0.2	1.0
Chest pain or discomfort	0.2	0.3	1.0	-0.2	-0.3	-1.0	-0.2	-0.1	-0.3	-0.4	-0.8
Had major operations	0.4	0.5	1.0	-1.0	0.4	-0.7	0.3	-0.6	-0.4	-0.9	-0.8
Age at last live birth	1.0	1.5	2.4	1.5	-0.5	0.2	0.2	1.6	1.6	1.6	1.6
Family relationship satisfaction	1.7	2.1	4.2	-1.2	-0.3	-1.8	0.3	-1.8	-2.1	-1.5	-1.6
Leg pain on walking	1.0	1.2	3.3	-1.0	-0.7	-1.2	1.0	-1.1	-0.0	-1.2	-1.8
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	5.8	0.9	-2.4	-0.2	-1.2	0.2	-0.6	0.5	0.1
Commuting to job workplace: Car/motor vehicle	1.2	1.4	2.6	-1.0	1.1	-1.6	1.0	-0.8	-1.0	-1.3	-1.4
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	4.0	0.8	-2.0	0.7	-1.7	-0.1	-0.8	0.4	-0.0
Medication: Aspirin	0.2	0.3	0.9	-0.7	0.7	-0.0	0.2	0.3	-0.9	-0.7	0.3
Supplements: Vitamin C	1.8	2.1	6.2	-0.7	-1.0	-1.2	-0.1	-2.5	-0.3	-1.6	-2.3
Knee pain experienced in last month	1.0	1.5	3.5	-1.2	0.8	-1.9	1.3	-1.2	0.0	-1.2	-1.3
Hypertension (Self-reported)	0.1	0.2	0.4	-0.5	0.2	0.3	0.4	-0.1	0.2	-0.5	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.9	-0.5	0.4	-0.9	-0.0	-0.2	-0.9	-0.3	0.1
Illnesses of father: Heart disease	0.4	0.6	1.8	-0.7	0.6	-1.3	0.8	0.2	-0.3	-0.5	-1.1
Illnesses of siblings: Diabetes	2.9	3.6	7.7	-1.5	-1.1	-2.0	-1.1	-2.2	-2.2	-1.7	-2.8
Smoking status: Previous	0.7	1.0	2.5	-0.0	0.4	1.1	1.2	-0.9	1.5	-0.4	-1.6
Forced expiratory volume in 1-second (FEV1), predicted	0.5	0.9	2.3	-1.4	0.6	0.6	1.0	-1.5	-0.0	-1.0	-0.9
Whole body fat-free mass	0.2	1.2	5.8	0.2	0.9	-2.4	0.9	-1.4	0.3	0.3	-0.4
Leg fat-free mass (right)	0.2	0.8	3.3	0.3	1.2	-1.8	0.9	-0.8	0.1	0.6	0.4
Arm fat percentage (left)	0.3	1.3	3.9	-0.3	2.0	-1.8	1.6	0.5	-0.7	0.4	0.4
Average weekly red wine intake	0.4	0.5	1.7	-0.4	0.0	-1.3	-0.4	-0.7	-0.5	-0.6	-1.1
Handedness (chirality/laterality): Left-handed	0.5	0.6	2.0	0.7	0.1	1.4	-1.0	0.5	-0.3	0.9	0.7
Mood swings	0.3	0.6	1.8	-0.6	-0.9	0.3	-0.7	-1.4	0.2	-0.7	-1.0
Loneliness, isolation	0.4	0.6	1.6	1.0	-0.9	0.3	-1.3	-0.8	-0.1	0.8	-0.3
Long-standing illness, disability or infirmity	0.2	0.2	1.8	0.2	-0.2	-0.2	-0.1	-0.1	1.3	0.0	0.0
Ever had bowel cancer screening	0.2	0.3	0.8	-0.6	0.5	-0.7	0.9	0.2	-0.5	-0.2	0.2
Diabetes diagnosed by doctor	0.2	0.3	1.5	0.1	0.0	-0.5	-0.4	-0.2	-1.2	-0.1	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	3.2	-0.8	0.9	-1.8	1.0	0.1	0.0	-1.1	-0.6
Friendships satisfaction	0.5	0.7	2.8	-0.2	1.3	-0.4	0.3	-0.5	-1.7	0.1	-0.4
Qualifications: nursing, teaching	0.6	1.0	3.1	1.1	-1.1	0.4	-1.8	0.9	-0.1	1.3	0.4
Commuting to job workplace: Walk	1.3	1.4	5.2	0.6	-2.2	0.6	-2.3	-0.2	-0.7	0.2	-0.2
Eye problems/disorders: Cataract	1.2	1.4	3.9	-1.3	0.2	0.8	2.0	-0.8	1.1	-1.2	-1.3
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	1.3	1.1	-0.5	0.2	0.6	-0.9	1.0	0.9	-1.1
Medication for cholesterol	0.6	0.8	1.7	0.9	-0.7	0.8	-1.3	0.8	0.2	1.2	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	3.5	-1.4	0.8	-0.3	1.9	-0.2	1.6	-1.3	-0.6
Back pain experienced in last month	0.5	0.8	1.6	1.2	0.3	1.3	-0.1	0.8	1.0	0.8	0.6
Mineral and other dietary supplements	1.0	1.4	3.3	-1.6	1.8	-1.7	1.0	-0.0	-0.6	-0.9	0.1
Breast cancer (self-reported)	0.7	0.8	1.6	1.1	-0.6	-0.7	-1.3	0.9	-0.2	0.9	0.9
Asthma (self-reported)	1.7	3.4	9.5	-1.7	1.8	-3.1	1.8	-1.6	-0.3	-2.2	-0.9
Osteoporosis (self-reported)	0.8	1.0	2.9	0.6	1.1	0.7	0.9	0.5	1.7	0.7	1.3
Osteoarthritis (self-reported)	0.6	0.7	1.5	-1.2	1.2	-0.4	1.2	-0.3	0.2	-1.1	-0.0
Medication: Aspirin	0.6	0.8	2.1	-1.4	0.8	-0.4	0.3	-0.3	-1.2	-1.3	-0.2
Medication: Gliclazide	0.2	0.3	0.9	0.6	-1.0	-0.1	-0.7	0.3	0.2	0.4	-0.1
Illnesses of father: None of the above (group 1)	3.1	3.9	6.5	2.2	-1.8	2.5	-2.1	1.6	0.8	2.3	1.8
Smoking status: Current	0.7	1.1	2.5	-1.5	0.9	-1.2	1.1	-0.6	-1.6	-0.5	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.2	2.7	1.2	-0.7	-1.6	-1.1	1.0	-0.5	1.3	0.8
Whole body water mass	0.2	1.2	6.2	0.3	0.8	-2.5	0.8	-1.4	0.3	0.3	-0.3
Leg predicted mass (right)	0.2	0.9	3.9	0.3	1.2	-2.0	0.8	-0.8	0.1	0.5	0.4
Arm fat mass (left)	0.3	1.4	4.7	-0.0	1.9	-2.2	1.6	0.0	-0.5	0.5	0.3
Number of self-reported non-cancer illnesses	0.5	0.8	1.8	0.6	1.2	-0.2	1.1	1.1	0.2	0.7	1.3
Average weekly champagne plus white wine intake	0.8	1.0	3.1	-1.3	1.1	-1.8	0.6	-0.1	-0.9	-1.1	-0.1
Miserableness	0.7	1.3	3.3	0.4	-1.3	-0.1	-0.1	-1.5	1.7	-0.2	-1.8
Guilty feelings	2.4	3.6	9.1	2.1	-3.0	2.2	-2.1	0.4	2.1	1.4	0.2
Wears glasses or contact lenses	0.4	0.5	1.6	-0.3	1.2	0.5	1.3	0.4	0.6	-0.1	0.2
Ever taken oral contraceptive pill	0.5	0.6	4.1	-0.3	-0.1	-2.0	0.1	-0.2	-0.7	-0.2	-0.1
Hearing aid user	1.0	1.1	4.1	-0.3	0.2	-1.4	-0.4	-1.1	-2.0	-0.3	-1.2
Mother’s age at death	1.0	1.2	3.5	0.4	-1.9	-0.8	-1.4	-0.9	0.1	-0.4	-1.5
Financial situation satisfaction	1.3	1.7	2.5	-1.6	1.5	-1.0	1.0	-1.2	-1.1	-1.6	-1.3
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.4	-0.3	0.1	0.2	-0.4	0.1	-0.7	-0.4	0.4
Commuting to job workplace: Public transport	0.5	0.6	1.5	0.8	-0.2	0.5	-0.7	0.5	0.9	1.0	1.2
Eye problems/disorders: Glaucoma	0.9	1.0	3.0	1.5	-0.8	1.7	-1.2	0.7	-0.0	0.7	0.0
Medication: Blood pressure	0.7	1.3	2.7	-1.6	-0.3	-0.6	0.2	-1.1	-0.9	-1.6	-1.6
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.8	0.0	-0.2	1.3	-0.2	-0.3	-0.4	-0.3	-1.0
Supplements: Fish oil (including cod liver oil)	0.5	0.7	2.6	0.6	-1.6	1.1	-0.3	-0.4	0.7	0.1	-0.7
High cholesterol (Self-reported)	0.2	0.3	1.0	0.2	0.1	-0.4	0.4	-0.6	-1.0	-0.4	-0.8
Medication: Bendroflumethiazide	0.6	0.8	3.8	-0.5	-0.5	0.2	0.3	-1.2	-0.3	-0.8	-2.0
Medication: Paracetamol	0.5	0.8	2.6	-1.4	0.2	-0.3	0.5	-1.2	-0.4	-1.6	-0.6
Medication: Lisinopril	0.6	0.7	2.0	-0.9	-0.7	0.0	-0.3	-1.0	-0.3	-1.1	-1.4
Medication: Atorvastatin	0.4	0.5	1.0	-0.7	0.8	-0.2	0.2	-0.5	-0.7	-1.0	-0.7
Illnesses of father: High blood pressure	1.3	1.6	3.8	-1.0	1.2	-2.0	1.4	-1.1	0.1	-1.2	-1.3
Alcohol drinker status: Never	1.6	1.9	3.5	1.7	-0.6	1.4	-0.3	1.5	1.5	1.9	1.5
Ever smoked	0.3	0.6	1.6	0.5	0.7	0.9	1.3	-0.4	1.1	0.5	-0.0
Basal metabolic rate	0.2	1.1	5.6	0.2	0.9	-2.4	0.9	-1.2	0.2	0.4	-0.2
Leg fat percentage (left)	0.3	1.1	4.8	-0.5	1.2	-2.2	1.2	-0.3	-0.8	-0.1	-0.4
Arm fat-free mass (left)	0.3	1.5	9.1	0.5	0.3	-3.0	0.3	-1.4	-0.1	0.4	-0.5
Number of operations (self-reported)	1.0	1.5	3.9	-1.6	-0.0	-1.8	0.6	-0.5	-0.0	-2.0	-1.3
Average weekly beer plus cider intake	0.3	0.5	3.0	-0.3	-1.7	-0.5	-0.2	-0.2	0.3	-0.1	-0.6
Irritability	0.5	0.9	3.1	-0.5	0.3	-1.3	0.5	-1.8	-0.6	-0.7	-0.9
Risk taking	1.1	1.6	10.6	-0.7	0.7	-3.3	0.0	-0.0	-0.9	-0.5	-0.3
Ever had prostate specific antigen (PSA) test	2.6	3.0	5.8	-1.4	-0.8	-2.4	-0.6	-2.4	-1.7	-1.7	-2.0
Fractured/broken bones in last 5 years	0.4	0.5	2.4	-0.5	-0.9	-0.0	0.3	0.5	1.6	0.4	0.4
Age started oral contraceptive pill	1.7	2.2	6.1	2.5	-1.9	0.2	-1.9	0.5	-0.6	1.8	0.2
Diastolic blood pressure, automated reading	0.1	0.3	1.0	-0.2	0.6	-0.5	-0.4	-0.1	-1.0	0.0	-0.9
Ever depressed for a whole week	1.4	1.7	6.0	0.6	-0.8	-1.8	-1.7	-0.6	-2.5	0.3	-0.5
Unable to work because of sickness or disability	0.4	0.5	1.7	-0.2	0.7	-0.5	-0.1	1.3	-0.1	0.5	1.1
Commuting to job workplace: Cycle	0.9	1.1	2.9	1.4	-0.8	-0.4	-1.2	0.7	-1.7	1.2	-0.0
Myopia	0.4	0.6	1.1	-0.5	-0.4	-1.0	-1.0	-0.6	-0.9	-0.1	1.0
Vascular/heart problems diagnosed by doctor	0.3	0.7	1.5	1.2	0.1	0.4	0.1	0.9	0.3	1.2	1.2
Cholesterol lowering medication	0.4	0.7	1.4	-0.5	0.2	-1.2	0.8	-0.7	-0.4	-1.1	-1.0
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	2.0	0.5	1.4	-1.4	0.9	0.8	-0.3	0.9	0.5
Pain experienced in last month	0.8	1.4	2.9	1.0	-1.2	0.6	-1.7	1.0	0.3	1.2	1.5
Supplements: Calcium	0.5	0.5	2.1	-0.6	0.3	0.6	1.4	-0.8	0.6	-0.4	-0.3
Basal cell carcinoma (self-reported)	0.7	0.8	1.8	-1.2	0.4	-0.7	1.3	-0.9	1.0	-0.8	-0.6
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.3	0.5	-0.3	-0.3	-0.9	1.5	0.8	1.0	1.1
Deep venous thrombosis (DVT) (self-reported)	2.4	3.1	7.9	-2.3	-0.0	-1.6	0.5	-2.0	-0.8	-2.8	-2.0
Heart disease (siblings)	0.2	0.3	1.0	-0.1	-0.6	-0.4	-0.5	-0.1	-0.6	-0.2	-1.0
Alcohol drinker status: Previous	0.3	0.4	1.0	-1.0	0.5	-0.4	0.1	0.3	-1.0	-0.4	0.2
Pack years of smoking	0.8	1.1	3.3	-0.6	1.8	-0.8	1.1	1.0	-0.8	0.3	1.2
Impedance of whole body	0.3	1.6	5.4	-1.7	0.2	2.3	0.8	-0.4	-0.5	-1.7	-0.6
Leg fat mass (left)	0.3	1.3	5.0	-0.6	1.2	-2.2	1.5	-0.9	-0.6	-0.3	-0.7
Arm predicted mass (left)	0.3	1.4	8.7	0.4	0.3	-3.0	0.3	-1.4	-0.1	0.3	-0.6