Hub : Genes

AVPI1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1660	0.0350	8.1e-11	0.133	0.101	0.153	0.144	0.160	6.4e-16	3.0e-12	3.4e-18	3.7e-17	5.4e-19
2	GTEx	Brain Cortex	0.1460	0.0650	9.0e-03	-0.003	NA	-0.003	NA	0.004	4.0e-01	NA	4.0e-01	NA	2.5e-01
3	GTEx	Brain Frontal Cortex BA9	0.3086	0.1216	8.2e-03	-0.005	NA	0.058	NA	0.006	4.7e-01	NA	1.2e-02	NA	2.2e-01
4	ROSMAP	Brain Pre-frontal Cortex	0.2479	0.0451	0.0e+00	0.108	0.182	0.203	0.209	0.212	9.1e-14	8.7e-23	1.4e-25	2.6e-26	1.0e-26
5	YFS	Blood	0.0626	0.0190	2.0e-05	0.030	0.015	0.039	0.040	0.042	3.7e-10	7.2e-06	8.1e-13	3.5e-13	1.5e-13
6	TCGA	Rectum Adenocarcinoma	0.8480	0.0750	7.3e-04	0.061	0.144	0.137	NA	0.107	1.5e-02	3.0e-04	4.3e-04	NA	1.8e-03
7	TCGA	Stomach Adenocarcinoma	0.0610	0.0300	1.6e-04	0.031	0.050	0.061	NA	0.049	2.4e-03	1.7e-04	3.2e-05	NA	1.8e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.2	0.3	1.4	0.0	1.2	0.0	0.4	-0.5	-0.7	0.0
Bipolar Disorder or Schizophrenia	0.2	0.5	2.4	-0.8	0.6	-0.1	0.2	-0.6	0.1	-1.5
Depressed Affect (Nagel 2018)	0.8	1.6	3.7	-1.6	-1.1	-0.4	-1.0	1.9	1.3	-1.1
Depression (Nagel 2018)	0.5	0.8	2.2	-0.2	-1.5	-0.5	0.6	0.9	1.0	-1.0
Intelligence (Savage-Jansen 2018)	1.5	4.5	7.7	-1.7	2.2	-2.4	-2.8	0.5	-1.8	2.6
Neuroticism (Nagel 2018)	1.6	3.7	6.4	-2.2	-2.5	-1.0	-1.6	2.4	1.6	-1.6
Schizophrenia (2018)	0.4	0.9	4.5	-1.0	-0.2	-0.1	-0.1	-0.3	0.8	-2.1
Schizophrenia vs Biploar Disorder	2.4	3.1	5.3	-2.3	-2.2	-2.2	-2.3	0.2	0.8	-1.0
Worry (Nagel 2018)	0.8	1.7	4.8	-0.6	-2.2	-0.7	-0.1	2.1	0.6	-1.2
Alzheimer’s Disease (in mother)	0.3	0.3	1.3	0.5	0.1	-0.1	0.2	-1.1	0.1	0.9
Alzheimer’s Disease (in father)	0.7	0.7	1.9	-1.0	1.4	-1.2	-0.4	0.4	-0.6	0.2
Alzheimer’s Disease (including proxy)	0.6	0.8	2.6	0.5	1.2	-0.4	0.3	-0.7	-0.9	1.6
Crohns Disease (2017)	1.0	2.3	7.2	-0.8	0.2	1.6	0.5	0.2	2.3	-2.7
Irritable Bowel Disease (IBD)	0.9	2.1	5.9	-1.3	-0.2	0.7	-0.4	1.0	2.3	-2.4
Ulcerative Colitis (UC)	0.6	1.1	2.6	-1.0	-0.7	-0.8	-1.1	1.1	1.6	-0.8
Major Depression (MDD)	0.8	1.0	3.5	-1.9	0.8	-0.7	-0.7	0.1	0.7	-1.1
Reaction Time	0.4	0.8	2.5	1.1	0.4	0.3	0.5	0.8	-0.7	1.6
Verbal and Numeric Reasoning (VNR)	0.8	1.9	5.1	-0.5	2.3	-1.7	-1.1	0.8	-0.4	1.7
Breast Cancer	0.8	2.0	10.1	0.4	-1.8	-0.3	0.4	-3.2	0.1	0.3
Ovarian Cancer	0.8	1.0	2.6	1.3	0.7	1.6	1.6	-0.2	0.1	-0.2
Prostate Cancer	0.2	0.3	0.9	0.5	-0.3	-0.3	-0.2	0.8	-0.1	0.9
Age at First Birth	0.7	1.0	3.3	0.6	1.5	1.8	0.6	-0.0	-1.0	0.4
Bipolar Disorder (2011)	0.6	0.6	1.8	-1.3	0.7	-0.8	-1.1	0.0	-0.4	0.0
Body Mass Index (BMI) (2010)	0.7	1.0	4.1	-1.1	0.1	1.0	0.4	-0.1	0.8	-2.0
Coronary Artery Disease (CAD)	0.6	0.7	2.9	0.0	1.7	-0.4	1.0	0.0	0.2	-0.8
Crohns Disease (2012)	0.7	1.2	3.9	-0.6	0.7	1.3	0.3	1.3	0.2	-2.0
Mean Putamen Volume	2.3	2.6	7.7	-2.8	-0.6	-1.5	-2.2	-0.3	1.0	-1.4
Fasting Glucose	0.6	0.7	1.7	-0.2	0.7	-1.3	-0.6	1.2	0.9	0.7
HbA1C	0.8	0.9	2.7	-0.8	1.6	-0.5	0.2	-1.0	0.5	-1.2
HDL Cholesterol	0.4	0.7	1.4	-1.2	-1.0	-0.5	-1.1	0.0	0.9	0.0
LDL Cholesterol	0.6	1.0	2.6	-1.4	-0.1	-1.6	-1.5	0.0	-0.1	0.2
Lupus	1.1	1.7	3.8	-0.3	-0.6	-1.3	-1.5	1.9	-1.0	1.7
Neuroticism (2016)	1.4	2.0	5.3	-1.4	-2.3	-1.1	-1.0	0.1	1.4	-1.6
Primary Biliary Cirrhosis	0.1	0.2	0.6	-0.2	-0.3	0.5	-0.3	0.0	0.7	-0.2
Rheumatoid Arthritis	0.9	1.2	3.1	0.5	-1.4	0.8	0.9	0.5	1.8	-1.3
Schizophrenia (2014)	0.8	1.8	5.8	-2.0	-1.1	-0.3	-0.7	0.6	0.5	-2.4
Triglycerides	0.4	0.7	2.4	0.6	1.5	0.6	0.5	0.0	-1.1	0.6
Type 2 Diabetes (T2D) (2012)	1.3	1.5	3.7	0.8	1.6	-0.1	-0.3	0.0	-1.8	1.9
Ulcerative Colitis	0.5	0.7	1.3	-0.8	-1.0	0.4	-0.9	0.7	0.9	-1.1
Blood Eosinophil Count	0.5	3.8	7.8	0.4	-2.8	2.2	1.4	-0.0	2.6	-2.3
Blood Platelet Count	0.2	1.9	7.7	1.1	-1.2	0.3	1.0	1.1	-2.8	0.5
Blood Red Count	0.1	1.2	2.5	1.4	1.5	0.4	0.8	0.1	-1.1	1.6
Blood White Count	2.4	17.5	110.2	1.8	-10.5	-0.2	0.8	-0.8	1.6	-2.4
Heel T-Score	0.4	3.6	7.8	2.2	2.1	1.6	2.8	0.1	2.2	-0.8
BMI	0.6	3.7	15.9	1.0	4.0	1.8	2.0	-0.7	-1.1	-0.1
Height	0.2	3.1	18.8	-0.4	-4.3	0.2	-1.2	-0.2	-0.9	0.3
Waist Hip Ratio (WHR)	0.4	1.9	6.8	-1.9	-0.0	-0.8	-2.6	0.7	-0.2	1.3
Systolic Blood Pressure	0.3	1.6	3.1	1.7	0.6	-0.2	1.1	1.4	-1.8	1.2
Smoking Status	0.5	1.1	3.3	-1.8	0.3	-0.9	-1.2	-0.7	-0.8	-1.0
Allergy or Eczema	0.7	1.8	4.0	1.9	0.6	1.0	2.0	0.5	-1.4	1.1
Cardiovascular Disease	0.2	0.6	1.9	-0.1	1.0	-1.4	-0.5	-0.7	0.1	0.5
Hypothyroidism (self reported)	0.2	0.4	1.4	0.1	1.2	1.0	0.5	0.3	-0.5	-0.3
Respiratory disease	0.4	0.9	2.6	0.1	-0.0	-1.1	-0.6	1.1	-1.1	1.6
Type 2 Diabetes (T2D) (2018)	0.9	1.7	4.6	-0.1	2.1	-1.3	-0.6	-1.3	-1.4	1.2
Lung FEV1/FVC ratio	0.2	1.2	6.9	0.7	2.6	0.5	0.5	-0.5	-0.2	0.2
Lung FVC	0.6	3.2	12.9	-1.6	3.6	-1.9	-1.5	0.8	0.9	-0.2
Neuroticism	0.8	2.0	4.6	-1.6	-2.2	-1.3	-1.3	1.0	1.2	-1.1
Chronotype (morning person)	0.2	0.4	1.3	0.9	0.1	0.5	0.4	0.8	1.1	0.2
Hair Pigment	0.2	5.5	13.8	3.5	1.0	3.0	3.7	-1.4	-0.5	-0.2
Tanning	0.1	1.6	3.8	-1.2	1.9	-1.2	-0.4	0.1	1.3	-1.6
Hand grip strength (left)	0.6	1.7	8.0	-0.9	2.8	-0.6	-0.8	1.0	0.4	0.9
Number of treatments/medications taken	1.5	2.7	6.2	1.9	-0.7	1.2	2.5	-2.4	0.0	-1.2
Average weekly spirits intake	1.0	1.2	4.7	-1.1	-0.4	1.0	-0.0	-0.8	0.8	-2.2
Sensitivity / hurt feelings	1.5	2.5	6.0	-2.2	-1.2	-1.8	-2.4	1.3	0.6	0.1
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.1	-0.1	-0.5	-0.5	-0.3	0.2	1.1	0.8
Hearing difficulty/problems: Yes	0.8	1.2	2.3	-1.3	1.1	-1.5	-1.5	-0.7	0.5	0.6
Relative age of first facial hair	0.5	1.1	2.6	0.4	1.2	0.3	0.1	-1.6	-1.6	0.8
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.5	0.3	1.1	-1.2	-0.5	-0.8	-0.7	1.2
Ever used hormone-replacement therapy (HRT)	1.1	1.4	4.2	-0.9	2.0	-0.1	-0.5	-1.8	-0.9	-0.8
Ever had hysterectomy (womb removed)	2.1	2.3	7.1	1.8	1.2	0.5	2.0	-2.7	-0.6	-0.5
Systolic blood pressure, automated reading	0.3	1.0	1.7	1.3	1.1	0.8	1.2	-0.5	-1.2	-0.1
Eye problems/disorders: Diabetes related eye disease	1.3	1.4	3.6	1.1	1.6	0.5	1.9	-0.4	1.2	-0.7
Angina	4.2	5.6	15.3	2.7	1.4	3.6	3.9	0.1	0.2	-1.2
Medication for hormone replacement therapy	0.5	0.5	2.9	0.0	1.7	0.1	-0.1	-0.7	0.1	-0.5
Vitamin and mineral supplements	0.4	0.6	3.1	0.7	0.7	0.1	-0.3	-0.1	-0.0	1.8
Supplements: Zinc	0.2	0.2	0.9	0.1	-0.1	0.3	-0.3	0.2	-0.4	1.0
Medication: Co-codamol	0.4	0.5	1.3	-0.9	0.7	0.5	-0.3	-0.1	-0.7	-1.1
Medication: Metformin	1.0	1.5	5.5	0.4	1.2	-1.2	-0.6	-0.2	-1.1	2.3
Diabetes (father)	0.9	1.1	3.5	1.4	1.9	-0.1	1.1	-0.7	0.3	0.7
Diabetes (mother)	1.6	2.0	6.8	0.2	2.6	-1.0	-0.7	0.3	-0.5	2.4
Severe depression (siblings)	2.0	2.3	4.7	1.7	2.2	1.7	1.6	0.3	-1.2	1.1
Pack years adult smoking proportion	0.6	1.0	3.5	-1.3	-0.5	0.5	0.0	0.7	0.8	-1.9
Impedance of leg (right)	0.2	1.0	4.2	0.5	-2.1	1.4	0.0	-0.5	0.2	0.3
Leg fat-free mass (left)	0.1	0.4	1.1	-0.3	-0.1	-0.9	-0.5	0.1	-1.1	0.4
Trunk fat percentage	0.2	0.8	1.6	1.3	0.9	0.8	1.2	-0.4	-0.0	0.8
Hand grip strength (right)	0.3	0.9	4.2	0.2	2.1	-0.6	-0.3	-0.1	0.1	1.2
Townsend deprivation index at recruitment	0.4	0.6	2.0	-1.4	-0.5	-0.6	-0.8	-0.2	0.0	-0.9
Current tobacco smoking	0.5	0.7	2.4	-1.6	0.5	-0.2	-0.9	-0.5	-0.6	-1.0
Average weekly fortified wine intake	0.3	0.4	0.9	0.3	-0.3	0.7	0.8	1.0	-0.2	-0.4
Maternal smoking around birth	1.9	2.8	7.7	-2.8	-0.6	-1.1	-2.0	-0.1	2.1	-1.4
Fed-up feelings	1.0	1.8	4.2	-2.0	-1.0	-0.8	-1.2	1.1	1.5	-1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	3.7	-0.9	-1.9	-1.2	0.3	1.0	1.3	-1.4
Relative age voice broke	0.3	0.5	1.6	-0.7	0.0	-0.9	-0.7	0.1	-1.3	-0.4
Taking other prescription medications	1.2	1.9	4.9	1.4	0.4	0.7	1.5	-2.2	-1.8	-0.5
Age when periods started (menarche)	0.2	0.6	2.3	0.7	0.2	-0.4	0.9	-0.5	-1.5	0.0
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	3.2	0.5	1.8	-0.6	0.3	-1.3	-0.7	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	2.1	0.5	1.1	1.4	1.4	-0.5	0.2	-0.8
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	3.8	0.3	0.1	-1.2	-0.8	-1.4	-2.0	1.3
Qualifications: CSEs or equivalent	0.6	0.8	2.3	1.5	0.5	0.6	1.2	-0.1	-0.8	0.7
Serious illness, injury or assault to yourself	0.3	0.3	0.8	-0.1	0.9	-0.2	-0.4	-0.4	-0.7	0.8
High blood pressure	0.2	0.5	1.5	0.9	0.2	-0.0	1.2	-0.4	0.4	-0.7
Hayfever, allergic rhinitis or eczema	0.4	1.0	2.1	1.2	0.1	0.6	1.2	0.6	-1.4	1.1
Multivitamins +/- minerals	0.6	0.8	4.0	-0.4	-0.7	-0.2	0.7	-0.2	0.3	-2.0
Stomach or abdominal pain in last month	0.1	0.2	0.8	-0.5	0.1	0.3	0.0	0.0	-0.9	-0.4
Supplements: Glucosamine	0.4	0.6	1.3	-1.1	0.9	-0.2	-0.5	-0.4	0.4	-1.1
Diverticular disease/diverticulitis (self-reported)	0.7	0.9	1.8	1.1	-0.2	1.1	1.3	1.3	0.1	-0.1
Medication: Atenolol	1.3	1.7	3.7	1.6	-0.5	1.0	1.9	-0.6	1.9	-0.5
Medication: Levothyroxine sodium	1.1	1.9	4.2	0.6	0.8	2.1	2.0	0.6	0.4	-1.8
Sitting height	0.5	3.7	6.0	-1.7	-2.1	-2.1	-2.1	1.9	-2.5	0.6
Chronic bronchitis/emphysema (father)	0.7	0.9	2.1	-0.5	1.5	-0.4	-0.1	-1.2	1.2	-0.8
High blood pressure (mother)	0.5	0.8	1.8	0.6	1.1	1.4	0.8	-0.9	0.2	0.6
Body mass index (BMI)	0.3	1.3	6.1	0.7	2.5	0.6	1.3	-0.2	-0.5	0.0
Impedance of leg (left)	0.1	0.7	3.3	0.2	-1.8	1.0	-0.2	-0.1	0.4	0.7
Leg predicted mass (left)	0.1	0.4	1.1	-0.4	-0.1	-1.0	-0.6	-0.0	-1.0	0.4
Trunk fat mass	0.2	0.7	1.3	1.1	0.8	0.7	1.1	-0.4	-0.5	0.7
Waist circumference	0.1	0.2	1.0	0.1	1.0	-0.3	0.1	0.1	-0.3	0.3
Number of incorrect matches in round	0.3	0.5	1.8	-1.0	0.1	-0.2	-0.5	1.4	-0.3	0.3
Past tobacco smoking	1.1	2.1	6.2	2.5	0.5	1.4	2.2	0.1	0.9	0.7
Alcohol usually taken with meals	3.2	5.2	18.0	2.2	1.0	-1.3	-0.4	0.1	-3.3	4.2
Nervous feelings	2.3	4.3	17.2	-1.5	-4.1	-1.7	-1.0	1.7	1.4	-1.4
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	4.4	-0.9	-0.3	0.4	-0.1	1.4	2.1	-1.0
Hearing difficulty/problems with background noise	1.4	2.2	6.0	-2.3	-0.1	-1.9	-2.5	0.3	-0.5	0.2
Hair/balding pattern: Pattern 2	0.2	0.2	1.2	-0.1	0.2	-0.1	0.3	1.1	-0.3	0.1
Had menopause	0.8	0.9	2.8	0.6	1.2	0.2	0.1	-1.0	-1.7	0.9
Had other major operations	0.1	0.2	0.6	-0.2	0.8	-0.3	0.2	0.5	0.1	-0.2
Forced vital capacity (FVC)	0.4	1.4	3.0	-0.8	1.3	-1.1	-1.7	1.1	-0.7	1.3
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	1.9	0.5	0.7	1.1	1.4	-1.1	0.7	-0.9
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.6	-1.3	1.1	-0.6	-0.6	-0.0	-0.2	-0.3
Qualifications: None of the above	0.5	1.0	3.5	0.2	-1.0	1.1	0.8	-0.7	0.4	-1.9
Financial difficulties in last 2 years	0.8	1.0	4.4	-0.2	1.0	0.4	0.5	2.1	-1.2	0.0
Mouth/teeth dental problems	1.3	2.0	3.6	1.6	1.6	1.3	1.5	-1.9	0.7	0.7
Heart attack	1.6	2.0	5.6	1.8	1.3	1.8	2.4	-0.3	-0.3	-0.5
Allergy	0.4	1.0	3.7	-0.7	0.1	0.2	-0.2	-0.3	1.9	-1.6
Pain all over the body in last month	0.5	0.5	1.2	-0.8	-0.9	-0.5	-0.6	-0.2	1.1	-0.6
Diabetes (self-reported)	0.5	0.7	1.9	-0.5	0.4	-1.4	-0.8	-0.2	-1.3	0.5
Hayfever/allergic rhinitis (self-reported)	1.5	1.9	5.6	1.7	0.5	1.8	2.4	-1.0	-0.9	-0.1
Medication: Ramipril	0.1	0.1	0.6	-0.0	0.8	-0.2	-0.1	-0.3	-0.5	-0.0
Medication: Simvastatin	1.7	2.5	6.9	2.0	2.6	0.5	1.7	-1.6	0.5	0.5
Fluid intelligence score	0.8	1.6	5.5	0.2	2.3	-0.6	0.3	1.8	-1.0	1.1
Illnesses of siblings	0.8	1.1	6.0	-0.4	-2.4	-0.4	0.0	0.7	-0.5	-0.8
Neuroticism score	0.9	2.0	3.8	-2.0	-1.8	-0.8	-1.3	1.5	1.1	-1.0
Weight	0.1	0.4	1.6	0.5	0.8	0.2	0.6	0.2	-1.3	0.4
Impedance of arm (right)	0.4	1.8	8.5	-0.6	-2.9	-0.8	-1.5	0.1	0.9	0.4
Arm fat percentage (right)	0.2	0.9	3.8	0.9	1.9	0.6	1.0	0.1	-0.3	0.4
Trunk fat-free mass	0.2	0.9	3.8	-0.7	-0.2	-0.8	-0.8	0.8	-2.0	0.2
Hip circumference	0.1	0.4	1.4	1.0	0.2	0.3	1.2	0.1	-0.6	-0.2
Time employed in main current job	0.9	1.1	2.3	1.1	-1.1	1.5	1.0	-0.7	1.1	0.0
Alcohol intake versus 10 years previously	0.4	0.6	1.6	0.7	0.5	0.4	1.3	1.2	0.2	-0.4
Father’s age at death	1.5	2.0	9.9	0.9	0.3	-1.1	-0.9	-0.1	-0.9	3.1
Worrier / anxious feelings	0.9	1.6	6.7	-0.9	-1.3	-0.4	0.3	0.2	1.4	-2.6
Frequency of tiredness / lethargy in last 2 weeks	0.6	0.9	2.5	-1.6	0.3	-0.8	-1.1	0.9	-1.1	-0.2
Falls in the last year	1.1	1.5	3.1	0.5	-1.3	1.7	1.8	0.1	-0.6	-1.4
Hair/balding pattern: Pattern 3	1.1	1.7	3.9	1.8	1.2	1.7	2.0	0.1	0.1	0.5
Number of live births	0.7	0.9	2.4	-1.2	0.4	-0.2	-1.5	1.6	0.5	0.3
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	3.6	-0.0	1.9	-0.5	-0.8	0.7	-0.6	1.2
Pulse rate	0.5	0.8	2.1	-1.4	1.2	-0.1	-0.5	0.3	0.6	-1.1
Happiness	0.9	1.1	3.4	-1.8	0.3	0.0	-1.2	1.1	1.3	-0.2
Noisy workplace	0.4	0.6	1.8	-0.4	-0.8	1.3	-0.4	-0.8	-0.4	-0.6
Qualifications: A levels/AS levels or equivalent	0.3	0.6	2.0	-0.9	0.6	-0.8	-1.4	0.3	0.8	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	1.6	0.3	0.2	0.3	0.7	0.5	1.3	-0.2
Mouth/teeth dental problems: Dentures	0.4	0.8	2.5	-1.1	-1.2	-0.2	-0.4	-0.2	0.1	-1.6
Asthma	0.7	1.4	3.6	0.0	0.2	-1.3	-1.1	0.7	-1.6	1.9
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.1	3.2	1.0	0.3	1.1	1.8	0.6	-0.2	-1.3
Medication: Cholesterol lowering	0.7	1.0	3.6	0.6	1.9	0.4	1.1	-1.3	0.4	-0.1
Depression (self-reported)	1.0	1.2	4.5	-0.2	-0.7	1.0	1.2	-0.9	0.3	-2.1
Medication: Lansoprazole	1.4	1.6	4.0	2.0	1.0	0.5	2.0	-0.7	-1.2	0.5
Prospective memory result	0.7	0.8	2.9	1.2	-1.7	0.8	0.3	-0.3	0.1	0.9
Lung cancer (father)	0.3	0.4	1.1	0.1	-0.3	0.5	0.4	1.0	1.0	-0.2
Illnesses of mother	0.4	0.4	1.7	0.2	-0.9	0.1	0.5	0.4	-0.3	-1.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	4.0	-0.5	2.0	-0.2	-1.1	0.8	-0.1	0.9
Pulse wave Arterial Stiffness index	1.1	1.2	3.2	1.8	1.0	-0.4	1.7	-0.6	-1.0	0.5
Impedance of arm (left)	0.2	1.0	5.3	0.1	-2.3	0.0	-0.7	-0.6	0.7	0.4
Arm fat mass (right)	0.1	0.5	2.1	0.5	1.5	0.2	0.6	0.0	-0.7	0.5
Trunk predicted mass	0.1	0.8	3.6	-0.7	-0.2	-0.7	-0.8	0.7	-1.9	0.2
Standing height	0.3	2.8	11.4	-0.6	-3.4	-0.9	-1.7	0.7	-1.7	1.0
Length of working week for main job	0.4	0.4	1.4	0.2	-0.5	0.5	0.7	1.2	0.7	-0.4
Exposure to tobacco smoke at home	0.3	0.4	1.5	0.5	-0.2	-0.4	0.9	-0.1	0.1	-1.2
Breastfed as a baby	1.4	1.7	5.8	0.6	-1.0	0.4	1.6	-1.4	0.5	-2.4
Tense / ‘highly strung’	0.5	0.8	2.7	0.6	-0.3	0.9	1.7	0.3	0.5	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	4.9	-0.0	2.2	-0.4	1.0	0.6	-0.6	-0.1
Hair/balding pattern: Pattern 4	0.1	0.3	0.6	0.1	0.8	0.7	0.3	0.1	0.7	-0.6
Birth weight of first child	0.6	1.1	3.9	0.6	-2.0	-1.1	-0.4	-0.8	0.6	0.8
Peak expiratory flow (PEF)	0.6	1.4	3.6	0.3	1.9	-1.3	-0.9	0.5	-0.8	1.7
Pulse wave reflection index	0.3	0.4	1.4	1.2	-0.0	-0.2	0.8	-0.7	0.2	0.5
Ever highly irritable/argumentative for 2 days	0.7	0.8	2.4	-0.8	0.8	-0.6	-0.9	0.6	-1.6	0.8
Loud music exposure frequency	0.7	0.8	2.0	-1.4	-0.8	-1.1	-0.9	0.3	0.4	-0.9
Qualifications: O levels/GCSEs or equivalent	1.0	1.5	3.4	-1.3	0.2	-1.6	-1.9	1.4	-0.0	1.0
Mouth/teeth dental problems: Bleeding gums	1.6	2.1	6.0	-0.9	-1.5	-1.0	-1.4	2.4	-1.1	1.4
Blood clot in the leg (DVT)	1.3	1.7	3.6	-1.8	-0.9	-1.9	-1.9	-0.5	0.4	0.2
Medication: Paracetamol	0.4	0.6	2.4	-0.2	-1.6	0.4	-0.0	0.3	-0.7	-1.1
Headache pain in last month	1.6	2.8	7.3	1.7	-0.4	2.7	2.7	0.7	0.3	-1.2
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	2.1	-1.2	-1.0	-0.4	-1.4	1.2	-1.3	-0.1
Glaucoma (self-reported)	1.3	1.5	3.3	-1.8	-1.0	-0.7	-1.5	-0.1	1.4	-1.1
Gout (self-reported)	1.4	2.0	6.1	1.7	0.1	1.4	1.0	0.2	-2.5	1.3
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	1.5	0.4	1.0	1.2	0.9	0.5	-1.1	-0.6
Medication: Amlodipine	0.6	0.8	2.7	-0.3	0.7	-0.1	0.6	-0.4	1.4	-1.6
Medication: Ventolin 100micrograms inhaler	2.0	2.6	8.4	1.4	-0.1	0.4	0.2	-0.1	-2.9	2.8
Birth weight	0.4	0.9	2.7	0.2	-1.6	-1.0	-0.1	-0.7	1.2	-0.7
Chronic bronchitis/emphysema (mother)	0.1	0.2	0.7	-0.5	-0.0	0.1	0.3	0.3	0.0	-0.8
High blood pressure (siblings)	0.9	1.3	6.4	0.6	2.5	0.6	0.4	-0.3	1.4	0.2
Forced vital capacity (FVC), Best measure	0.3	1.2	3.1	-0.6	1.8	-0.5	-1.4	1.0	-0.2	1.1
Body fat percentage	0.3	1.1	2.3	1.3	1.4	1.1	1.5	-0.6	-0.1	0.5
Leg fat percentage (right)	0.4	1.3	2.6	0.7	1.6	1.4	1.5	-1.2	0.1	-0.4
Arm fat-free mass (right)	0.1	0.5	2.5	0.0	0.6	-0.0	0.1	0.5	-1.6	0.6
Exposure to tobacco smoke outside home	1.3	1.8	3.0	-1.5	-1.4	-1.2	-1.0	-0.3	1.7	-1.6
Comparative body size at age 10	0.3	0.8	2.3	-0.9	-0.7	-1.1	-0.5	-0.0	1.5	-0.6
Number of full brothers	0.6	0.8	1.6	-1.3	0.2	-1.1	-0.6	1.2	0.9	-0.3
Worry too long after embarrassment	1.0	1.8	3.9	-0.7	-1.9	1.0	0.1	1.4	1.2	-2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	3.8	-0.7	1.9	1.1	0.9	-0.4	0.8	-1.4
Wheeze or whistling in the chest in last year	0.4	0.7	1.2	-1.0	-0.6	-0.7	-1.1	0.9	0.9	0.6
Number of children fathered	0.8	0.9	1.9	-1.4	-1.3	0.2	-1.2	0.6	-0.9	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	1.8	1.3	1.4	0.9	1.3	0.5	-1.1	0.2
Age at first live birth	0.2	0.3	0.7	-0.0	-0.1	-0.0	-0.4	0.6	-0.8	0.8
Pulse wave peak to peak time	1.2	1.4	3.8	-1.9	-1.0	0.2	-1.9	0.7	0.8	-0.3
Health satisfaction	0.7	0.9	2.7	0.0	1.6	0.3	-0.3	0.2	-1.2	1.5
Shortness of breath walking on level ground	1.0	1.2	3.4	0.1	1.4	-0.4	-0.6	-0.5	-1.5	1.8
Qualifications: College or University degree	0.2	0.7	3.0	0.1	-0.1	-0.9	-0.9	0.1	0.1	1.7
Eye problems/disorders: None of the above	0.4	0.4	1.6	-0.1	0.3	-0.8	-0.5	1.3	0.6	0.1
Mouth/teeth dental problems: Loose teeth	3.2	3.8	7.2	-2.7	-2.1	-1.7	-2.2	2.1	0.8	-1.3
Emphysema/chronic bronchitis	0.2	0.2	0.6	-0.4	0.8	-0.4	-0.4	0.4	-0.4	-0.3
Medication for pain relief, constipation, heartburn	0.9	1.5	4.6	-1.9	0.1	-1.1	-2.1	0.4	0.9	0.7
Neck or shoulder pain in last month	0.3	0.5	1.5	-0.9	-0.4	-0.7	-0.6	-0.4	-0.1	-1.2
Medication: Blood pressure	1.3	2.2	5.1	1.7	0.6	1.4	2.3	-1.6	1.3	-1.0
Angina (self-reported)	4.1	5.3	14.9	2.8	1.3	3.5	3.9	0.2	0.2	-0.8
Migraine (self-reported)	0.6	0.7	1.2	1.0	-0.8	1.1	0.9	-1.0	-0.3	0.4
Medication: Ibuprofen	0.4	0.5	1.7	0.2	-0.6	0.5	1.0	0.2	0.1	-1.3
Medication: Allopurinol	0.3	0.4	0.9	0.8	-0.9	0.7	0.2	-0.4	-1.0	0.2
Medication: Omeprazole	0.5	0.6	1.0	0.9	1.0	0.4	0.6	-1.0	-0.7	0.8
Medication: Seretide 50 evohaler	0.1	0.1	0.4	-0.1	0.1	0.2	-0.2	-0.2	-0.6	0.6
Mean time to correctly identify matches	0.7	1.4	2.9	1.7	1.1	0.9	1.3	0.2	-0.7	1.7
Heart disease (mother)	0.4	0.5	3.2	-0.1	1.8	0.1	-0.1	-0.7	0.1	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	3.1	-0.7	-0.0	-1.7	-1.8	0.1	-1.4	1.1
Whole body fat mass	0.2	0.8	1.6	1.1	1.1	0.8	1.3	-0.5	-0.5	0.5
Leg fat mass (right)	0.2	0.8	1.6	0.8	1.3	1.1	1.2	-0.8	-0.5	0.2
Arm predicted mass (right)	0.1	0.6	3.6	-0.0	0.6	-0.2	-0.1	0.3	-1.9	0.6
Pulse rate, automated reading	0.3	0.8	2.8	-0.9	-0.5	0.6	-0.3	-0.9	0.8	-1.7
Alcohol intake frequency.	1.0	2.4	5.7	1.1	-0.1	2.2	2.4	-0.3	-0.7	-2.1
Comparative height size at age 10	0.3	1.5	4.4	1.3	-2.1	0.0	-0.2	-0.0	-0.5	2.0
Number of full sisters	0.5	0.6	1.6	-0.7	1.3	0.8	0.1	-0.9	0.9	-0.3
Suffer from ‘nerves’	0.8	1.2	6.8	-0.6	-2.6	-0.5	-0.2	0.9	-0.4	-0.3
Overall health rating	0.8	1.7	5.3	0.8	0.2	2.3	1.6	-0.4	0.1	-1.8
Chest pain or discomfort	0.3	0.4	1.5	-0.3	1.2	0.8	0.1	-0.1	-0.0	0.5
Had major operations	0.4	0.5	1.7	0.8	0.6	0.3	1.3	0.7	-0.1	-0.4
Age at last live birth	0.7	1.0	2.1	-1.1	-1.2	-0.5	-1.4	0.7	-0.9	0.8
Family relationship satisfaction	0.8	1.0	2.5	-1.6	1.3	-0.3	-1.5	0.4	0.5	0.1
Leg pain on walking	0.8	1.1	2.9	-0.7	1.6	-0.1	-0.3	-1.7	-1.2	-0.2
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	2.5	-1.6	0.8	-0.3	-0.8	1.4	0.6	-1.4
Commuting to job workplace: Car/motor vehicle	0.8	0.9	3.2	0.1	1.8	1.3	0.7	-0.7	0.1	-0.6
Illness, injury, bereavement, stress in last 2 years	0.0	0.0	0.1	0.0	0.3	0.2	-0.2	-0.1	-0.1	-0.2
Medication: Aspirin	1.1	1.5	3.3	1.7	0.8	1.3	1.8	-1.2	0.0	0.0
Supplements: Vitamin C	0.4	0.5	0.9	-0.8	0.1	-0.9	-0.9	0.2	-1.0	0.3
Knee pain experienced in last month	0.4	0.6	1.8	-1.3	-0.7	0.5	-0.5	-0.7	-0.7	-0.8
Hypertension (Self-reported)	0.1	0.4	1.3	1.0	0.4	0.0	1.1	-0.4	0.3	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	0.9	0.7	0.8	0.5	0.9	0.4	0.4	0.1
Illnesses of father: Heart disease	0.9	1.3	2.6	-1.4	1.6	-1.1	-1.6	-0.6	0.2	0.4
Illnesses of siblings: Diabetes	0.6	0.7	1.9	-0.4	1.4	-0.2	-0.7	-0.7	1.2	0.8
Smoking status: Previous	0.6	0.9	1.9	-1.4	-0.7	-1.0	-1.3	-0.1	-0.8	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	5.4	-0.5	-2.3	-0.1	-0.8	-0.4	-0.7	0.0
Whole body fat-free mass	0.1	0.7	2.6	-0.6	-0.1	-0.9	-0.8	0.6	-1.6	0.3
Leg fat-free mass (right)	0.1	0.6	1.5	-0.4	0.0	-1.2	-0.7	0.3	-1.2	0.8
Arm fat percentage (left)	0.3	1.3	4.6	1.2	2.1	1.1	1.4	-0.4	-0.3	0.3
Average weekly red wine intake	1.9	2.8	7.0	-1.5	1.0	-2.6	-2.4	1.0	0.8	1.4
Handedness (chirality/laterality): Left-handed	1.0	1.2	4.4	-1.1	-1.3	-2.1	-1.0	0.2	0.2	-0.5
Mood swings	1.0	1.7	4.6	-2.2	-1.4	-0.0	-1.2	1.4	0.8	-1.2
Loneliness, isolation	0.3	0.4	1.1	-0.3	-0.4	0.1	-0.6	1.1	0.9	0.3
Long-standing illness, disability or infirmity	0.5	0.7	2.4	-0.0	-0.6	-0.3	-0.2	-1.6	-1.4	-0.5
Ever had bowel cancer screening	2.4	2.8	8.7	-2.5	-0.2	-1.2	-0.8	-0.0	1.5	-3.0
Diabetes diagnosed by doctor	0.8	1.3	2.7	0.0	1.1	-1.6	-0.6	-1.3	-1.6	0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	2.0	-1.4	1.0	-0.7	-0.7	0.8	0.4	-1.0
Friendships satisfaction	2.9	3.6	10.1	-2.8	-0.0	-1.9	-3.2	1.5	0.1	1.1
Qualifications: nursing, teaching	0.2	0.3	0.8	0.5	0.0	-0.0	-0.2	-0.8	0.7	0.9
Commuting to job workplace: Walk	0.6	0.7	3.6	0.1	0.5	0.0	-0.0	1.9	-0.5	0.7
Eye problems/disorders: Cataract	1.4	1.6	4.3	1.1	-0.9	0.3	0.9	-2.1	-1.9	0.4
Mouth/teeth dental problems: Mouth ulcers	1.0	1.5	3.5	-1.1	-0.2	-0.5	-1.8	1.3	-1.9	0.7
Medication for cholesterol	0.4	0.6	1.6	0.0	-0.6	1.3	0.6	0.7	-1.3	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	2.3	1.0	-0.2	0.6	1.5	0.1	-0.9	-0.7
Back pain experienced in last month	0.4	0.5	2.1	0.6	0.8	1.5	0.6	0.1	-0.2	-0.0
Mineral and other dietary supplements	1.0	1.3	4.4	1.6	0.2	0.4	0.7	-0.2	-1.2	2.1
Breast cancer (self-reported)	1.9	2.3	5.2	1.8	1.9	2.3	1.7	0.2	-0.9	0.7
Asthma (self-reported)	0.4	0.9	2.5	0.1	0.1	-1.2	-0.8	0.5	-1.0	1.6
Osteoporosis (self-reported)	0.4	0.4	1.7	-0.2	-1.3	-0.0	0.3	0.9	0.3	-0.6
Osteoarthritis (self-reported)	0.6	0.8	3.2	-0.1	-0.7	0.6	0.3	-1.8	-0.1	-1.1
Medication: Aspirin	0.5	0.7	1.8	1.2	0.5	0.8	1.3	-0.8	-0.1	-0.0
Medication: Gliclazide	0.9	1.0	2.5	1.2	1.1	-0.2	0.7	-0.4	-1.6	1.2
Illnesses of father: None of the above (group 1)	0.9	1.1	2.5	1.6	-1.0	1.4	1.3	0.6	-0.2	0.3
Smoking status: Current	0.4	0.6	1.5	-1.2	0.9	-0.1	-0.6	-0.4	-0.6	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.8	9.6	0.1	3.1	0.4	0.1	1.3	0.7	0.7
Whole body water mass	0.1	0.7	2.5	-0.6	-0.0	-0.9	-0.7	0.5	-1.6	0.4
Leg predicted mass (right)	0.1	0.7	1.7	-0.4	0.1	-1.3	-0.7	0.3	-1.3	0.8
Arm fat mass (left)	0.2	0.8	3.1	0.8	1.8	0.6	0.8	-0.2	-0.8	0.5
Number of self-reported non-cancer illnesses	0.8	1.4	2.6	1.4	1.6	1.1	1.6	-1.0	0.2	-0.3
Average weekly champagne plus white wine intake	0.8	1.1	5.6	0.4	0.9	0.4	-0.6	-0.1	-0.7	2.4
Miserableness	0.9	1.6	4.0	-2.0	-1.6	-0.7	-1.4	0.6	0.6	-1.2
Guilty feelings	1.3	1.9	3.3	-1.8	-1.5	-0.4	-1.2	1.7	1.7	-0.7
Wears glasses or contact lenses	0.5	0.6	1.1	-0.3	-0.2	-0.8	-0.8	-0.8	-1.0	0.9
Ever taken oral contraceptive pill	1.4	1.6	5.8	0.1	2.4	-1.0	-0.2	0.3	-1.7	1.1
Hearing aid user	1.4	1.6	4.2	0.6	1.7	0.1	-0.2	0.6	-2.0	1.8
Mother’s age at death	0.5	0.6	1.2	0.6	1.1	1.1	0.4	0.3	-0.3	1.1
Financial situation satisfaction	0.3	0.4	1.4	-0.6	0.7	0.5	-0.2	-0.2	-1.2	0.6
Tinnitus: Yes, now most or all of the time	1.0	1.1	2.4	-1.5	0.1	-0.6	-0.7	1.2	-0.9	-1.5
Commuting to job workplace: Public transport	1.0	1.2	4.4	0.1	-1.6	-0.9	-0.4	-0.6	-2.1	0.5
Eye problems/disorders: Glaucoma	0.5	0.6	1.3	-0.9	-1.1	0.7	-0.4	-0.3	0.7	-1.1
Medication: Blood pressure	0.4	0.7	3.5	-0.2	0.6	-1.9	-0.6	0.2	0.2	0.7
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.2	-0.3	-0.3	-0.2	-0.3	0.1	0.4	-0.4
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.9	-0.9	-0.3	-0.7	-0.9	0.4	0.2	-0.7
High cholesterol (Self-reported)	1.0	1.9	5.4	-0.4	2.3	-1.5	-1.5	0.1	0.4	1.7
Medication: Bendroflumethiazide	0.1	0.1	0.3	-0.2	0.5	-0.5	-0.1	0.5	-0.0	-0.0
Medication: Paracetamol	0.5	0.8	2.8	-0.6	-1.7	0.3	-0.3	0.1	-1.0	-1.0
Medication: Lisinopril	1.4	1.9	3.9	-0.6	-0.7	-2.0	-1.8	-1.5	1.0	1.4
Medication: Atorvastatin	0.5	0.6	1.6	-0.7	0.4	-0.7	-1.3	-0.6	-0.9	0.6
Illnesses of father: High blood pressure	0.8	1.0	3.0	-1.2	0.4	-1.0	-1.7	0.0	-0.2	1.0
Alcohol drinker status: Never	0.4	0.5	1.6	0.4	0.5	1.3	0.7	-0.2	-0.0	-0.9
Ever smoked	1.3	2.3	6.2	-2.5	-1.5	-1.2	-2.2	-0.5	-0.7	-0.8
Basal metabolic rate	0.1	0.5	2.6	-0.3	0.2	-0.7	-0.5	0.4	-1.6	0.4
Leg fat percentage (left)	0.3	1.1	3.4	0.5	1.9	1.2	1.4	-0.9	0.3	-0.4
Arm fat-free mass (left)	0.1	0.6	2.2	-0.6	0.8	-0.5	-0.5	0.6	-1.5	0.4
Number of operations (self-reported)	0.2	0.3	0.8	0.6	0.9	-0.3	0.9	-0.1	-0.4	0.1
Average weekly beer plus cider intake	0.2	0.2	0.7	-0.8	0.2	-0.3	-0.4	-0.4	-0.2	-0.7
Irritability	2.3	3.9	8.4	-1.7	0.2	-2.9	-2.9	0.6	-0.7	2.7
Risk taking	1.0	1.4	5.5	-0.3	2.3	1.3	0.6	0.7	-1.3	-0.3
Ever had prostate specific antigen (PSA) test	1.8	2.1	8.2	-1.7	-0.7	-1.0	-0.8	0.5	2.9	-1.0
Fractured/broken bones in last 5 years	0.6	0.8	2.8	-1.0	0.2	-0.3	0.0	0.1	-1.2	-1.7
Age started oral contraceptive pill	0.5	0.6	3.1	0.2	1.8	0.0	-0.2	-0.0	-0.9	0.5
Diastolic blood pressure, automated reading	0.1	0.4	1.3	0.3	0.8	1.1	0.7	-0.4	-0.3	-0.6
Ever depressed for a whole week	1.0	1.3	4.0	-1.9	2.0	-0.3	-1.1	0.1	-0.1	-0.3
Unable to work because of sickness or disability	1.0	1.3	2.3	1.1	1.2	1.3	1.5	0.0	1.5	-0.1
Commuting to job workplace: Cycle	1.2	1.4	6.7	-0.5	2.6	0.3	0.3	-0.3	1.2	-1.0
Myopia	1.2	1.7	6.1	0.1	-1.5	-2.5	-0.5	-0.1	1.7	0.5
Vascular/heart problems diagnosed by doctor	0.3	0.9	2.6	-1.1	-0.4	-0.7	-1.6	0.3	-0.9	1.1
Cholesterol lowering medication	0.5	0.8	2.8	0.7	1.7	-0.3	-0.2	-1.2	0.5	0.5
Medication: Omeprazole (e.g. Zanprol)	0.9	1.0	2.9	1.2	1.7	0.0	0.9	-0.6	-1.0	0.8
Pain experienced in last month	0.2	0.4	1.0	0.9	0.4	-1.0	-0.0	-0.3	0.2	0.8
Supplements: Calcium	0.4	0.4	0.8	-0.9	-0.9	-0.4	-0.7	0.1	-0.7	-0.5
Basal cell carcinoma (self-reported)	0.9	1.0	1.9	-0.6	-1.4	-0.7	-1.2	1.4	0.8	0.9
Heart attack/myocardial infarction (self-reported)	1.8	2.3	6.4	1.9	1.5	1.8	2.5	-0.7	-0.2	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	2.7	-1.5	-0.3	-1.6	-1.6	-0.5	0.3	0.3
Heart disease (siblings)	0.4	0.5	1.4	0.0	1.2	0.4	0.2	-0.5	1.2	0.2
Alcohol drinker status: Previous	1.1	1.3	4.3	1.1	0.6	1.2	2.1	-0.1	-0.2	-1.3
Pack years of smoking	0.7	1.0	3.6	-1.2	-0.2	0.6	0.2	0.7	0.9	-1.9
Impedance of whole body	0.2	1.1	5.8	0.4	-2.4	0.4	-0.5	-0.3	0.7	0.8
Leg fat mass (left)	0.2	0.8	2.4	0.7	1.5	0.9	1.1	-0.6	-0.2	0.2
Arm predicted mass (left)	0.1	0.6	2.4	-0.6	0.5	-0.3	-0.6	0.6	-1.5	0.4