Hub : Genes

ARHGAP19

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0710	0.0320	2.0e-03	0.051	0.011	0.020	NA	0.045	6.9e-07	1.5e-02	1.5e-03	NA	3.2e-06
2	GTEx	Adipose Subcutaneous	0.0750	0.0330	3.1e-03	0.082	NA	0.066	NA	0.073	3.3e-07	NA	4.0e-06	NA	1.3e-06
3	GTEx	Artery Tibial	0.0866	0.0345	1.6e-03	0.059	NA	0.033	NA	0.049	2.0e-05	NA	1.2e-03	NA	9.3e-05
4	GTEx	Lung	0.1402	0.0500	3.3e-04	0.048	NA	0.018	NA	0.027	1.4e-04	NA	1.5e-02	NA	3.6e-03
5	GTEx	Skin Not Sun Exposed Suprapubic	0.1450	0.0580	2.6e-03	0.064	NA	0.049	NA	0.051	2.2e-04	NA	1.1e-03	NA	8.9e-04
6	GTEx	Skin Sun Exposed Lower leg	0.1590	0.0390	8.4e-09	0.106	NA	0.110	NA	0.121	4.7e-09	NA	2.2e-09	NA	3.4e-10
7	GTEx	Whole Blood	0.1880	0.0450	2.2e-08	0.136	NA	0.142	NA	0.135	1.5e-12	NA	5.0e-13	NA	2.0e-12
8	METSIM	Adipose	0.0737	0.0230	7.3e-07	0.033	0.032	0.033	NA	0.042	7.7e-06	1.0e-05	7.5e-06	NA	6.3e-07
9	NTR	Blood	0.0967	0.0186	0.0e+00	0.098	0.073	0.090	0.095	0.094	8.3e-30	1.5e-22	2.0e-27	5.5e-29	7.5e-29
10	TCGA	Breast Invasive Carcinoma	0.0222	0.0109	3.0e-03	0.004	0.006	0.009	NA	0.006	4.2e-02	1.6e-02	4.7e-03	NA	1.6e-02
11	TCGA	Brain Lower Grade Glioma	0.0357	0.0190	2.6e-03	0.035	0.009	0.007	NA	0.015	7.3e-05	3.0e-02	4.4e-02	NA	6.5e-03
12	TCGA	Pancreatic Adenocarcinoma	0.1240	0.0650	8.3e-03	-0.004	0.009	-0.005	NA	-0.005	5.0e-01	1.3e-01	6.0e-01	NA	6.0e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bipolar Disorder (2018)	3.3	5.2	9.0	-2.6	-2.8	-2.6	-2.7	-3.0	-2.7	-0.8	-2.4	0.3	-1.5	-2.5	-1.3
Bipolar Disorder or Schizophrenia	3.5	8.5	13.7	-3.3	-3.5	-3.2	-3.1	-3.7	-3.3	-0.4	-3.0	0.9	-3.6	-3.2	-1.2
Depressed Affect (Nagel 2018)	0.6	1.2	1.9	1.3	0.7	1.4	1.0	1.1	1.3	-1.0	1.1	-1.3	-0.9	0.0	1.4
Depression (Nagel 2018)	0.2	0.3	0.8	0.6	0.4	0.6	0.4	0.6	0.4	-0.1	0.9	-0.1	-0.5	0.3	0.8
Intelligence (Savage-Jansen 2018)	2.6	8.1	11.9	-3.2	-3.4	-3.3	-3.3	-3.1	-3.0	-0.8	-3.5	0.1	0.2	-3.3	-3.4
Neuroticism (Nagel 2018)	4.1	9.6	16.0	4.0	3.4	4.0	3.7	3.7	3.9	-1.2	3.1	-1.9	0.4	1.6	3.4
Schizophrenia (2018)	1.9	3.9	11.8	-2.1	-2.2	-2.0	-1.7	-2.3	-2.0	0.1	-2.0	0.8	-3.4	-2.1	-0.5
Schizophrenia vs Biploar Disorder	0.6	0.8	1.6	0.6	0.9	0.8	1.0	0.5	0.3	1.2	1.2	1.3	-0.8	1.0	0.9
Worry (Nagel 2018)	3.7	7.8	13.1	3.6	3.6	3.3	3.6	3.5	3.0	0.7	3.1	-0.0	0.3	2.3	2.5
Alzheimer’s Disease (in mother)	0.7	0.8	2.6	-0.5	-1.2	-0.8	-0.8	-0.9	-0.5	-1.0	-0.8	-1.2	0.4	-1.6	-0.1
Alzheimer’s Disease (in father)	5.0	5.4	8.5	-2.8	-2.6	-2.7	-2.5	-2.8	-2.9	1.5	-2.1	1.9	-1.9	-1.2	-2.2
Alzheimer’s Disease (including proxy)	2.3	3.3	6.4	-2.1	-2.5	-2.2	-1.9	-2.3	-2.1	-0.1	-2.0	0.1	-0.5	-2.1	-1.4
Crohns Disease (2017)	0.2	0.4	0.7	0.6	0.5	0.8	0.7	0.6	0.7	-0.8	-0.8	-0.5	-0.2	-0.0	0.7
Irritable Bowel Disease (IBD)	0.2	0.4	1.4	0.2	0.2	0.4	0.7	0.2	0.5	-0.2	-0.8	-0.1	-1.1	0.6	1.2
Ulcerative Colitis (UC)	0.3	0.5	2.7	-0.2	-0.1	-0.1	0.5	-0.1	-0.1	0.9	-0.1	0.9	-1.6	1.0	0.9
Major Depression (MDD)	3.9	4.8	9.8	-2.6	-2.3	-2.5	-3.1	-2.6	-2.8	1.3	-2.2	1.7	-0.9	-1.7	-1.4
Reaction Time	1.0	2.0	5.0	-1.4	-1.0	-1.2	-1.0	-1.3	-1.4	1.2	-1.4	1.7	1.7	-0.7	-2.2
Verbal and Numeric Reasoning (VNR)	4.3	10.4	14.7	-3.6	-3.6	-3.7	-3.7	-3.8	-3.8	0.5	-3.7	1.5	-0.7	-3.4	-3.8
Breast Cancer	0.5	1.2	3.4	0.9	1.3	0.8	1.1	1.1	0.5	1.1	1.8	0.9	1.5	0.9	-0.6
Ovarian Cancer	0.2	0.2	0.8	0.1	0.2	0.2	0.1	-0.2	0.2	-0.7	-0.1	-0.6	0.8	-0.3	-0.9
Prostate Cancer	0.2	0.3	1.1	-0.1	0.1	-0.1	0.6	0.5	0.0	1.1	0.4	0.9	0.3	0.7	-0.6
Age at First Birth	0.9	1.2	3.0	-0.9	-0.9	-1.2	-1.1	-1.1	-1.0	0.9	-1.1	0.7	1.1	-1.3	-1.7
Bipolar Disorder (2011)	0.8	0.8	2.5	-0.6	-0.8	-0.4	-0.9	-1.3	-0.7	-1.6	-1.0	-0.5	-0.1	-1.2	0.1
Body Mass Index (BMI) (2010)	0.2	0.3	1.9	-0.3	-0.1	-0.2	-1.4	-0.8	-0.4	0.3	-0.2	0.2	-0.2	0.1	0.6
Coronary Artery Disease (CAD)	2.2	2.7	5.9	-1.9	-2.2	-2.1	-1.8	-1.6	-1.8	1.1	-0.9	1.2	-2.4	-0.6	-0.5
Crohns Disease (2012)	0.1	0.1	0.5	-0.3	-0.3	-0.1	-0.1	-0.1	-0.1	-0.5	-0.7	-0.1	0.0	0.1	0.2
Mean Putamen Volume	0.2	0.2	1.5	0.2	0.1	0.3	0.4	0.0	0.3	-0.7	0.1	-0.4	1.2	-0.4	-0.1
Fasting Glucose	4.2	5.0	9.0	-2.8	-2.3	-3.0	-2.5	-2.6	-2.7	1.7	-2.1	1.9	-0.5	-1.6	-2.1
HbA1C	1.8	2.0	3.5	-1.5	-1.8	-1.7	-1.9	-1.7	-1.2	-0.6	-1.9	-0.6	-0.3	-1.7	-1.0
HDL Cholesterol	0.3	0.4	1.1	0.6	0.5	0.4	1.0	0.7	0.6	0.6	1.0	0.3	-0.4	1.0	-0.4
LDL Cholesterol	0.2	0.3	1.4	-0.2	-0.4	-0.1	-0.3	-0.6	-0.4	-0.4	-0.7	-0.2	-1.1	-0.2	1.2
Lupus	0.4	0.6	3.2	0.3	0.2	0.5	0.1	-0.6	0.2	-1.8	-0.3	-1.1	0.3	-1.4	0.6
Neuroticism (2016)	2.0	3.0	5.3	2.2	1.9	2.3	2.2	2.2	2.0	0.2	1.9	0.0	0.2	1.0	1.9
Primary Biliary Cirrhosis	1.3	1.9	8.0	1.1	0.2	1.1	0.8	0.4	1.2	-2.8	0.1	-2.5	-0.2	-1.2	1.6
Rheumatoid Arthritis	3.7	5.0	10.1	2.6	2.1	2.6	3.2	2.7	2.6	-0.2	3.0	-0.6	0.1	2.4	1.8
Schizophrenia (2014)	1.6	3.5	9.7	-2.1	-2.2	-2.0	-1.7	-2.3	-2.1	0.2	-1.4	1.0	-3.1	-1.8	-0.4
Triglycerides	0.9	1.4	3.2	-1.1	-1.3	-1.0	-1.4	-1.4	-1.0	-1.1	-1.6	-0.3	-0.0	-1.8	1.0
Type 2 Diabetes (T2D) (2012)	1.1	1.3	2.2	-1.2	-1.4	-1.1	-1.2	-1.5	-1.3	-0.2	-1.4	0.4	-1.1	-1.5	0.0
Ulcerative Colitis	0.6	0.9	3.6	0.0	0.1	0.1	0.5	0.3	0.0	1.5	0.4	1.1	-1.3	1.9	1.3
Blood Eosinophil Count	2.7	20.8	36.6	5.3	5.1	5.2	5.4	6.0	5.3	0.4	5.1	-1.2	0.6	5.4	4.3
Blood Platelet Count	0.3	3.8	10.6	2.0	2.2	2.2	0.3	2.0	1.2	1.9	2.0	1.1	-0.9	3.3	2.5
Blood Red Count	0.3	3.3	6.0	-1.9	-1.9	-1.8	-2.2	-2.2	-1.8	0.1	-2.1	0.6	-0.3	-2.5	-2.2
Blood White Count	25.5	188.8	309.8	16.1	16.4	15.9	16.2	17.6	15.5	3.1	16.3	-1.4	5.0	15.8	11.0
Heel T-Score	0.4	2.9	8.9	-1.4	-1.2	-1.3	-1.6	-1.5	-1.2	-0.2	-2.2	0.5	3.0	-1.1	-2.9
BMI	2.4	13.8	25.2	-4.1	-4.3	-4.0	-5.0	-4.8	-3.7	-2.4	-4.2	-1.2	-1.6	-4.8	-1.6
Height	0.3	6.6	18.9	2.8	2.8	2.7	2.9	3.0	2.9	-1.1	4.3	-1.7	0.8	1.8	1.8
Waist Hip Ratio (WHR)	0.1	0.4	1.5	-0.0	-0.2	-0.0	-0.8	-0.3	-0.0	-1.0	-1.2	-0.6	0.5	-1.0	-0.7
Systolic Blood Pressure	0.6	3.0	8.9	-1.1	-1.0	-1.1	-0.7	-1.3	-1.6	2.9	-1.1	3.0	-2.3	0.2	-1.7
Smoking Status	0.3	0.7	2.8	0.1	-0.5	-0.0	-0.6	-0.4	0.2	-1.6	-0.5	-1.7	0.0	-1.1	0.8
Allergy or Eczema	0.5	1.2	3.2	-1.4	-1.2	-1.2	-1.2	-0.5	-1.2	1.8	-0.4	1.6	-0.6	0.1	-0.7
Cardiovascular Disease	0.4	1.3	3.5	-1.0	-0.7	-1.0	-1.2	-1.1	-1.3	1.2	-1.2	1.5	-1.9	-0.1	0.3
Hypothyroidism (self reported)	0.3	0.6	1.8	-0.2	-0.5	-0.1	-0.6	-0.7	-0.3	-0.8	-1.1	-0.7	-0.9	-0.9	1.3
Respiratory disease	2.4	5.3	10.2	-3.2	-2.7	-3.0	-3.0	-2.3	-3.1	1.8	-0.9	2.2	-1.0	-0.8	-1.6
Type 2 Diabetes (T2D) (2018)	3.0	5.7	11.8	-2.4	-2.6	-2.5	-3.2	-2.8	-2.5	-0.7	-3.4	0.3	-2.2	-2.6	-0.4
Lung FEV1/FVC ratio	0.5	2.4	6.8	-1.6	-1.3	-1.5	-1.8	-1.6	-1.6	0.4	-2.3	0.7	-0.0	-1.2	-2.6
Lung FVC	1.9	9.7	20.4	-3.2	-3.5	-3.2	-4.0	-3.6	-2.9	-2.0	-4.5	-1.0	0.3	-4.1	-2.0
Neuroticism	3.2	7.6	13.4	3.6	3.0	3.7	3.4	3.3	3.3	-0.6	2.6	-1.2	-0.6	1.7	3.4
Chronotype (morning person)	1.5	3.4	5.4	2.1	2.0	2.3	2.0	2.0	2.2	-1.4	1.4	-1.5	1.4	1.5	1.7
Hair Pigment	0.0	0.6	1.7	0.7	0.7	0.7	1.0	1.3	0.9	0.2	0.9	-0.2	-0.5	1.0	0.7
Tanning	0.1	1.2	2.5	-1.1	-1.3	-1.3	-1.6	-1.1	-0.7	-1.1	-1.2	-1.1	-0.6	-1.3	0.0
Hand grip strength (left)	3.8	9.9	21.2	-2.5	-3.1	-2.6	-3.8	-3.7	-1.8	-3.9	-3.9	-3.4	-0.5	-4.6	-1.0
Number of treatments/medications taken	0.5	0.8	3.0	-0.4	-0.4	-0.3	-0.0	0.0	-0.4	1.7	0.9	1.6	-1.5	0.8	0.3
Average weekly spirits intake	0.4	0.6	4.8	-0.2	-0.5	-0.2	-0.1	-0.2	-0.4	0.2	0.1	0.3	-2.2	0.4	1.0
Sensitivity / hurt feelings	3.8	6.6	11.0	3.3	2.7	3.3	2.7	2.7	3.3	-2.6	1.3	-2.9	0.5	0.9	2.5
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.3	0.4	-0.3	0.4	0.1	0.3	0.4	-0.7	-0.0	-0.7	-0.9	-0.7	1.1
Hearing difficulty/problems: Yes	1.7	2.6	5.3	-1.9	-1.8	-1.9	-1.6	-1.7	-1.6	-1.2	-1.3	-0.6	-1.9	-2.3	0.6
Relative age of first facial hair	3.0	6.1	11.6	-2.9	-3.2	-3.2	-3.4	-2.8	-2.4	-0.5	-2.6	-0.3	-0.8	-3.0	-1.5
Other serious medical condition/disability diagnosed by doctor	2.3	3.0	5.6	-1.9	-2.2	-1.8	-2.1	-2.0	-1.5	-1.2	-2.2	-0.8	-1.0	-2.4	-0.4
Ever used hormone-replacement therapy (HRT)	1.2	1.5	3.1	-1.0	-1.3	-1.3	-1.8	-1.5	-1.3	0.3	-1.4	0.5	-0.8	-1.8	-0.3
Ever had hysterectomy (womb removed)	1.3	1.5	2.8	-1.6	-1.7	-1.5	-1.4	-1.2	-1.4	0.4	-0.9	0.7	-1.4	-1.1	-0.3
Systolic blood pressure, automated reading	0.3	0.9	1.6	-0.8	-0.9	-1.1	-0.7	-1.1	-1.1	0.9	-0.9	0.9	-1.1	-0.8	-1.2
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	2.8	0.8	0.9	0.9	0.6	0.7	0.3	0.9	-0.4	1.1	-0.6	1.7	0.2
Angina	1.1	1.4	4.4	-0.7	-0.7	-0.6	-0.3	-0.2	-1.0	2.1	-0.8	2.0	-2.1	0.9	0.5
Medication for hormone replacement therapy	0.5	0.6	1.5	-0.4	-0.7	-0.4	-1.0	-1.0	-0.3	-0.8	-0.8	-0.6	1.1	-1.2	-0.4
Vitamin and mineral supplements	1.0	1.4	3.0	-1.1	-1.2	-1.2	-1.3	-1.3	-1.3	0.1	-1.6	0.5	0.1	-1.3	-1.7
Supplements: Zinc	0.1	0.1	0.5	0.3	0.0	0.2	0.2	0.0	0.1	-0.3	0.5	-0.4	0.7	-0.1	0.1
Medication: Co-codamol	1.4	1.6	4.1	-1.6	-2.0	-1.6	-1.7	-1.3	-1.2	-0.7	-1.1	-0.5	-0.8	-1.3	0.4
Medication: Metformin	1.8	2.5	5.1	-1.6	-2.3	-1.5	-1.9	-1.7	-1.6	-0.5	-1.9	0.5	-1.9	-1.9	-0.3
Diabetes (father)	0.5	0.6	1.3	-0.7	-0.5	-0.8	-0.7	-0.8	-0.8	0.4	-0.7	0.5	-1.1	-1.1	0.6
Diabetes (mother)	4.0	5.1	10.4	-2.3	-2.3	-2.5	-2.7	-2.7	-2.6	0.7	-3.2	1.1	-1.0	-2.3	-2.2
Severe depression (siblings)	5.6	6.3	13.9	-2.8	-2.7	-2.7	-3.7	-3.3	-2.6	-0.2	-3.1	-0.1	-0.9	-2.7	-1.9
Pack years adult smoking proportion	0.9	1.4	3.1	-1.3	-1.2	-1.4	-1.5	-1.0	-1.3	1.8	-0.8	1.2	-1.4	-0.5	0.4
Impedance of leg (right)	0.5	2.2	4.2	1.6	1.6	1.3	2.0	2.0	1.2	1.7	1.5	1.2	1.0	1.6	-0.3
Leg fat-free mass (left)	0.1	0.8	2.5	-0.5	-0.2	-0.4	-1.1	-0.9	-0.4	-1.6	0.2	-1.3	-0.9	-0.9	0.8
Trunk fat percentage	0.7	2.8	5.3	-1.8	-1.9	-2.1	-2.3	-2.0	-2.0	0.2	-1.1	0.5	-1.2	-2.1	-1.2
Hand grip strength (right)	3.2	8.8	16.5	-2.6	-3.0	-2.6	-3.9	-3.7	-2.0	-3.3	-3.5	-2.8	-1.2	-4.1	-1.0
Townsend deprivation index at recruitment	0.1	0.2	0.8	-0.3	-0.2	-0.1	-0.4	-0.3	-0.3	0.2	-0.2	0.2	-0.9	0.4	0.5
Current tobacco smoking	1.6	2.6	13.5	-1.4	-1.9	-1.6	-1.7	-1.3	-1.5	0.6	-1.1	0.4	-3.7	-0.9	0.5
Average weekly fortified wine intake	0.8	1.0	4.9	-0.7	-0.4	-0.7	-0.5	-0.2	-0.7	2.2	0.4	1.6	0.5	1.0	-0.9
Maternal smoking around birth	1.3	1.8	3.2	-1.6	-1.5	-1.8	-1.2	-1.4	-1.6	0.6	-0.6	0.8	-1.2	-1.5	-1.8
Fed-up feelings	0.2	0.3	0.6	0.8	0.3	0.8	0.8	0.6	0.7	-0.3	0.5	-0.3	0.3	-0.1	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.4	0.5	0.5	0.5	0.7	0.7	0.3	1.1	1.2	0.9	-0.5	0.9	0.4
Relative age voice broke	0.1	0.1	0.4	-0.3	-0.4	-0.4	-0.4	-0.2	-0.1	-0.4	-0.4	-0.6	-0.3	-0.6	0.0
Taking other prescription medications	0.9	1.4	3.1	-1.5	-1.5	-1.4	-1.3	-1.0	-1.3	1.0	-0.6	1.2	-1.8	-0.4	-0.3
Age when periods started (menarche)	0.3	0.8	3.2	-0.9	-1.1	-1.0	-0.6	-0.7	-0.8	-0.3	-0.5	0.0	-1.8	-1.3	-0.3
Bilateral oophorectomy (both ovaries removed)	2.2	2.5	4.4	-1.8	-1.8	-2.1	-1.9	-1.5	-1.9	1.5	-1.2	1.6	-0.5	-1.1	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.4	4.3	-1.9	-2.1	-1.7	-1.8	-2.0	-1.6	-0.9	-1.4	-0.3	-0.3	-2.0	-1.0
Tinnitus: Yes, but not now, but have in the past	0.0	0.0	0.2	0.3	-0.0	0.1	0.0	0.1	0.0	-0.2	-0.0	-0.0	-0.5	-0.2	-0.1
Qualifications: CSEs or equivalent	1.6	2.1	4.2	1.5	2.0	1.4	1.6	1.7	1.3	1.3	1.6	0.7	-0.0	2.1	1.1
Serious illness, injury or assault to yourself	3.0	3.6	6.0	-2.5	-2.4	-2.4	-2.4	-1.9	-2.3	1.3	-1.5	1.5	-0.9	-0.9	-1.8
High blood pressure	0.1	0.3	1.6	-0.3	-0.2	-0.5	-0.1	-0.3	-0.6	1.2	-0.2	1.2	-0.5	0.3	-0.1
Hayfever, allergic rhinitis or eczema	0.9	1.8	3.7	-1.6	-1.4	-1.6	-1.8	-1.2	-1.6	1.9	-0.6	1.7	-0.7	-0.4	-0.6
Multivitamins +/- minerals	1.5	1.9	5.6	1.1	1.4	1.4	1.4	1.3	1.3	0.1	1.6	-0.3	-0.4	1.9	2.4
Stomach or abdominal pain in last month	3.0	3.7	8.0	-2.2	-1.9	-2.1	-2.2	-2.1	-2.0	1.9	-1.2	1.8	-1.1	-1.2	-2.8
Supplements: Glucosamine	0.2	0.3	1.4	0.0	-0.1	-0.1	0.0	-0.3	0.0	-0.9	-0.3	-0.8	-0.3	-1.2	0.4
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	2.2	0.9	1.5	1.0	0.9	0.9	0.4	1.2	0.7	1.3	1.3	1.3	-0.6
Medication: Atenolol	1.4	1.8	3.6	1.3	1.5	1.4	1.9	1.7	1.3	0.7	1.4	0.3	0.3	1.7	1.2
Medication: Levothyroxine sodium	0.3	0.5	1.4	0.8	0.4	0.8	0.4	0.5	0.7	-0.7	-0.3	-1.2	-0.4	0.2	1.2
Sitting height	0.2	1.3	2.8	1.2	1.7	1.3	1.0	1.1	1.1	-0.5	1.5	-0.7	1.1	1.2	0.7
Chronic bronchitis/emphysema (father)	2.1	2.5	3.1	-1.6	-1.7	-1.8	-1.6	-1.5	-1.7	1.5	-1.4	1.4	-1.7	-1.4	-1.7
High blood pressure (mother)	0.3	0.5	1.4	0.5	0.8	0.5	0.4	0.3	0.2	0.9	-0.1	1.0	1.2	1.2	0.0
Body mass index (BMI)	1.5	6.3	11.4	-2.8	-2.9	-2.8	-3.4	-3.2	-2.7	-1.2	-2.5	-0.4	-1.9	-3.2	-0.7
Impedance of leg (left)	0.3	1.5	3.1	1.3	1.2	1.1	1.8	1.7	1.1	1.2	1.0	0.9	1.4	1.3	-0.5
Leg predicted mass (left)	0.2	0.8	2.8	-0.5	-0.3	-0.4	-1.1	-0.9	-0.4	-1.7	0.1	-1.4	-0.8	-1.0	0.8
Trunk fat mass	0.6	2.6	5.5	-1.8	-1.8	-1.9	-2.3	-2.0	-1.8	-0.5	-0.9	-0.1	-1.2	-2.2	-0.8
Waist circumference	0.7	2.4	7.1	-1.4	-1.5	-1.4	-2.0	-1.9	-1.3	-1.8	-1.4	-1.2	-0.3	-2.7	-0.3
Number of incorrect matches in round	0.2	0.3	0.9	-0.5	-0.2	-0.5	-0.8	-0.4	-0.7	0.3	-0.3	0.8	0.9	-0.3	-0.6
Past tobacco smoking	1.0	1.8	7.3	-0.8	-0.4	-0.5	-0.2	-0.2	-1.1	2.6	-0.4	2.7	-1.3	1.3	-1.4
Alcohol usually taken with meals	0.9	1.5	3.8	-1.2	-1.2	-1.2	-1.4	-1.5	-1.5	-0.1	-1.0	0.6	0.8	-1.0	-2.0
Nervous feelings	6.3	11.8	20.3	3.9	4.1	3.7	4.3	4.5	3.5	1.7	4.5	0.6	0.2	3.8	2.6
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	2.2	0.4	0.0	0.4	0.3	0.6	0.5	-0.0	0.1	-0.3	-1.5	0.1	0.8
Hearing difficulty/problems with background noise	1.9	3.1	5.1	-2.1	-2.3	-2.2	-1.8	-2.1	-2.0	-0.8	-1.3	-0.2	-1.9	-2.0	-0.5
Hair/balding pattern: Pattern 2	0.4	0.5	1.9	-0.6	-0.3	-0.6	-0.5	-0.6	-0.2	-0.9	-0.1	-0.7	1.1	-0.8	-1.4
Had menopause	1.5	1.9	2.9	-1.3	-1.4	-1.7	-1.3	-1.2	-1.7	1.4	-1.2	1.6	-0.5	-1.2	-1.6
Had other major operations	1.0	1.2	2.1	-1.2	-1.4	-1.3	-1.2	-1.3	-1.2	-0.7	-1.1	-0.4	-1.4	-0.7	-0.6
Forced vital capacity (FVC)	0.5	1.9	7.5	-0.6	-0.8	-0.5	-1.4	-1.0	-0.2	-2.7	-1.6	-2.3	1.1	-1.5	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	3.1	-1.6	-1.8	-1.4	-1.2	-1.4	-1.2	-0.6	-1.0	-0.2	-0.2	-1.2	-1.1
Ever unenthusiastic/disinterested for a whole week	2.1	2.5	4.5	-1.9	-2.1	-1.9	-1.7	-1.7	-1.6	-0.5	-2.0	0.1	-0.7	-2.1	-0.6
Qualifications: None of the above	0.6	1.2	3.0	1.2	1.1	1.3	0.9	1.2	1.3	0.2	1.7	-0.1	-0.2	0.6	1.6
Financial difficulties in last 2 years	2.7	3.6	5.4	-2.0	-2.3	-2.1	-2.2	-2.3	-2.3	0.6	-1.7	1.1	-2.1	-2.2	-1.1
Mouth/teeth dental problems	0.1	0.1	0.5	-0.3	-0.0	-0.1	-0.4	-0.1	-0.2	0.4	-0.7	0.3	-0.1	0.2	-0.3
Heart attack	0.2	0.3	0.6	-0.7	-0.1	-0.5	-0.7	-0.4	-0.7	0.3	-0.7	0.4	-0.1	0.8	-0.5
Allergy	1.3	2.9	4.8	2.1	1.8	2.0	2.1	1.5	2.1	-2.1	0.8	-2.2	1.0	0.4	0.9
Pain all over the body in last month	0.6	0.6	1.2	0.9	1.0	1.0	0.6	0.6	0.7	0.4	1.0	0.6	0.6	0.4	1.1
Diabetes (self-reported)	1.1	1.7	6.0	-1.1	-1.4	-1.0	-1.6	-1.2	-1.2	0.2	-1.5	0.8	-2.4	-1.2	0.5
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.7	-0.4	-0.7	-0.7	-0.5	-0.4	-0.4	0.4	-1.2	-0.0	-0.1	-0.3	-1.3
Medication: Ramipril	0.4	0.6	2.3	-0.5	-0.3	-0.7	-1.1	-0.8	-0.6	0.3	-1.5	0.1	-0.9	-0.7	0.3
Medication: Simvastatin	1.3	1.9	3.5	-1.5	-1.6	-1.5	-1.8	-1.5	-1.7	0.3	-1.8	0.6	-1.9	-0.9	0.0
Fluid intelligence score	6.1	12.7	19.6	-4.0	-4.2	-3.9	-4.0	-4.4	-3.9	-0.8	-4.4	0.6	-1.1	-4.2	-3.5
Illnesses of siblings	3.1	4.4	8.8	2.1	2.5	2.2	2.7	2.7	1.9	0.1	3.0	-0.0	0.4	2.8	1.4
Neuroticism score	2.4	5.1	8.7	2.8	2.5	2.9	2.9	2.8	2.6	-0.5	2.1	-0.8	-0.1	1.5	2.7
Weight	0.5	2.3	4.9	-1.4	-1.4	-1.3	-2.1	-1.8	-1.3	-1.9	-0.9	-1.4	-1.0	-2.2	0.2
Impedance of arm (right)	1.9	8.8	16.0	3.5	3.5	3.1	3.8	4.0	3.0	1.9	3.3	0.8	2.1	3.6	-0.1
Arm fat percentage (right)	0.8	3.1	5.9	-1.9	-2.0	-2.0	-2.4	-2.2	-1.9	-0.5	-1.8	-0.1	-1.2	-2.3	-1.2
Trunk fat-free mass	0.2	1.0	4.5	-0.6	-0.3	-0.3	-1.1	-1.0	-0.4	-2.1	-0.2	-1.7	-0.3	-1.0	0.8
Hip circumference	0.1	0.5	2.3	-0.2	-0.2	-0.1	-0.6	-0.7	-0.2	-1.5	0.3	-1.2	0.2	-1.1	0.4
Time employed in main current job	2.3	2.7	5.3	1.9	2.3	1.9	2.0	1.9	1.7	0.4	1.6	-0.1	0.7	2.1	1.2
Alcohol intake versus 10 years previously	0.1	0.2	0.9	-0.1	-0.3	-0.1	-0.2	-0.3	-0.2	-0.2	-0.1	0.2	0.8	-0.4	-0.9
Father’s age at death	0.2	0.2	0.6	0.7	0.6	0.6	0.2	0.2	0.5	0.1	0.6	0.1	0.8	-0.3	0.3
Worrier / anxious feelings	3.2	6.0	11.8	3.2	3.0	2.9	3.4	3.1	2.7	-0.4	2.1	-0.7	2.2	2.1	1.5
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.2	4.5	-0.6	-1.2	-0.6	-1.1	-1.2	-0.9	-0.7	-1.0	-0.0	-2.1	-1.7	0.7
Falls in the last year	0.3	0.4	1.7	-0.3	-0.2	-0.3	-0.2	-0.4	-0.4	0.9	-0.3	1.1	-1.3	-0.0	-0.2
Hair/balding pattern: Pattern 3	0.6	0.9	3.1	-0.4	-0.6	-0.8	-0.1	-0.5	-0.9	1.8	-0.6	1.6	-1.5	-0.4	0.4
Number of live births	0.5	0.7	4.5	-0.4	-0.9	-0.7	-0.6	-0.5	-0.3	-0.2	-0.8	-0.4	-2.1	-1.3	0.1
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	4.4	-1.0	-1.1	-0.9	-2.0	-1.6	-0.8	-2.1	-2.1	-1.6	0.6	-1.7	-0.8
Pulse rate	0.9	1.5	4.6	-0.9	-0.8	-1.1	-0.5	-0.8	-1.4	2.1	-1.0	2.1	-1.0	-0.2	-0.9
Happiness	0.7	0.8	2.8	-0.7	-1.1	-0.8	-0.7	-0.9	-1.0	-0.3	-1.1	0.4	-1.7	-1.1	-0.0
Noisy workplace	4.4	5.4	8.1	2.8	2.6	2.7	2.7	2.6	2.9	-1.8	1.6	-2.1	0.3	1.6	2.8
Qualifications: A levels/AS levels or equivalent	0.5	1.1	6.5	-0.1	-0.2	0.1	-0.0	-0.5	0.1	-2.6	-0.8	-1.7	1.3	-0.9	-0.7
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.9	-0.5	-0.9	-0.5	-0.8	-0.5	-0.2	-0.9	-0.8	-0.9	-0.7	-1.4	0.4
Mouth/teeth dental problems: Dentures	1.2	2.0	10.1	-0.5	-0.2	-0.7	0.0	0.4	-0.7	3.2	0.7	2.8	-0.8	1.5	-1.1
Asthma	2.5	4.8	9.2	-3.0	-2.5	-2.9	-2.8	-2.4	-2.9	1.7	-1.1	2.2	-1.1	-1.0	-1.2
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.3	0.1	0.0	0.1	-0.0	-0.2	-0.0	-0.2	-0.1	-0.3	-0.5	0.1	-0.6
Medication: Cholesterol lowering	1.0	1.5	2.9	-1.3	-1.4	-1.4	-1.4	-1.2	-1.5	0.1	-1.6	0.3	-1.7	-0.8	0.2
Depression (self-reported)	0.4	0.5	3.3	0.0	-0.2	-0.0	0.0	-0.0	0.2	0.4	-0.3	-0.0	-1.8	-0.6	1.5
Medication: Lansoprazole	1.2	1.4	2.2	-1.3	-0.9	-1.1	-1.2	-1.3	-1.4	1.1	-0.9	1.5	-1.0	-0.8	-1.2
Prospective memory result	4.1	5.1	7.6	2.5	2.3	2.0	2.8	2.5	2.0	1.9	2.6	0.8	-2.0	2.6	2.3
Lung cancer (father)	0.5	0.5	1.4	0.8	0.3	0.5	0.9	1.2	0.7	0.6	1.0	-0.1	0.4	1.2	-0.3
Illnesses of mother	0.6	0.8	2.0	0.6	0.3	0.6	0.8	0.9	1.0	-1.3	1.1	-1.4	-0.6	-0.0	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	4.4	-0.7	-0.6	-0.7	-1.6	-1.2	-0.6	-1.6	-2.1	-1.3	0.8	-1.2	-0.8
Pulse wave Arterial Stiffness index	0.2	0.2	0.7	0.1	0.2	0.1	-0.4	-0.4	-0.0	-0.7	-0.1	-0.5	-0.7	-0.7	0.8
Impedance of arm (left)	1.1	5.2	9.6	2.6	2.5	2.2	2.8	3.1	2.2	1.6	2.6	0.7	1.9	2.8	-0.6
Arm fat mass (right)	0.7	2.9	5.8	-1.8	-1.9	-1.8	-2.4	-2.2	-1.8	-1.1	-1.5	-0.5	-0.9	-2.3	-1.0
Trunk predicted mass	0.2	1.0	4.4	-0.5	-0.3	-0.3	-1.1	-0.9	-0.3	-2.1	-0.2	-1.7	-0.3	-1.0	0.8
Standing height	0.6	5.9	9.5	2.8	2.9	2.8	2.3	2.5	2.8	-1.9	3.1	-2.4	1.7	1.7	1.7
Length of working week for main job	1.2	1.3	2.5	1.4	1.4	1.4	1.3	1.6	1.0	-0.3	1.4	-0.1	0.3	0.8	1.3
Exposure to tobacco smoke at home	0.3	0.4	1.7	-0.2	0.0	-0.2	0.5	0.4	-0.2	0.9	0.1	0.7	-1.3	0.9	0.4
Breastfed as a baby	0.2	0.3	1.3	0.1	-0.0	0.2	0.7	0.3	0.5	-1.2	0.5	-0.9	0.4	-0.0	-0.0
Tense / ‘highly strung’	0.6	1.0	1.8	1.1	1.3	1.1	1.0	1.2	1.3	-0.6	1.1	-0.8	0.7	0.3	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	7.0	10.7	17.1	-3.9	-4.1	-4.1	-3.9	-4.1	-3.5	-0.3	-3.8	0.1	-2.2	-3.6	-1.9
Hair/balding pattern: Pattern 4	0.7	1.7	5.2	1.1	0.6	1.1	0.8	0.9	1.3	-2.2	0.2	-2.3	-0.4	-0.2	2.0
Birth weight of first child	6.2	11.3	18.7	3.8	4.2	3.6	3.7	4.3	3.8	-0.3	4.1	-1.6	2.0	3.9	2.2
Peak expiratory flow (PEF)	0.4	0.9	3.2	-0.9	-0.9	-0.8	-1.8	-1.3	-0.9	-0.4	-1.2	-0.1	0.5	-0.5	-1.0
Pulse wave reflection index	0.4	0.5	2.7	0.1	0.1	0.3	-0.4	-0.1	0.3	-1.1	0.3	-0.9	-0.8	-0.7	1.6
Ever highly irritable/argumentative for 2 days	1.0	1.2	2.1	-1.0	-1.5	-1.2	-1.4	-1.1	-1.2	0.2	-1.3	0.3	-1.4	-1.1	0.7
Loud music exposure frequency	1.0	1.1	4.5	1.2	1.1	1.5	0.7	0.8	1.0	-0.5	0.5	-0.3	-0.6	0.7	2.1
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	1.1	-0.5	-0.8	-0.7	-0.3	-0.5	-0.6	0.3	-0.5	0.3	-0.4	0.2	-1.0
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.0	-0.5	-0.8	-0.6	-0.2	-0.9	-0.8	-1.0	0.1	-0.2	-0.3	-0.6	0.7
Blood clot in the leg (DVT)	1.0	1.3	4.3	-1.1	-1.0	-1.0	-0.3	-0.7	-1.3	1.7	0.0	2.1	-1.1	0.0	-1.3
Medication: Paracetamol	0.9	1.4	4.0	1.2	1.0	1.0	1.6	1.2	1.1	0.2	2.0	0.0	-0.8	1.2	1.5
Headache pain in last month	0.2	0.3	1.5	0.2	0.5	0.1	0.4	0.2	-0.1	0.6	0.3	0.5	-1.2	1.2	0.2
Medication for cholesterol, blood pressure or diabetes	0.3	0.4	2.1	0.5	0.6	0.6	0.5	0.5	0.7	-0.3	0.7	-0.3	1.4	0.2	-0.8
Glaucoma (self-reported)	1.1	1.3	2.8	1.4	1.3	1.4	1.7	1.4	1.5	-1.0	0.6	-1.0	0.7	0.5	0.7
Gout (self-reported)	0.8	1.0	4.4	0.5	0.4	0.6	0.5	0.2	0.9	-1.5	0.8	-1.6	-0.6	-0.8	2.1
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.7	0.3	-0.1	0.4	-0.3	-0.3	0.3	-1.1	-0.9	-1.2	-1.0	-0.6	1.3
Medication: Amlodipine	0.8	1.1	2.2	-1.1	-1.0	-1.1	-1.4	-1.3	-1.1	0.8	-1.5	0.8	-0.0	-0.7	-0.8
Medication: Ventolin 100micrograms inhaler	2.8	3.7	7.5	-2.3	-2.0	-2.2	-2.0	-1.8	-2.4	2.6	-0.5	2.7	-0.8	-0.1	-1.3
Birth weight	2.5	5.5	9.4	2.7	3.1	3.0	2.5	2.6	2.9	-0.6	2.3	-0.8	1.4	2.6	1.9
Chronic bronchitis/emphysema (mother)	0.9	1.0	3.3	-0.8	-0.9	-0.8	-0.4	-0.5	-1.0	1.6	-0.6	1.8	-0.3	-0.4	-1.5
High blood pressure (siblings)	2.1	3.1	7.7	-1.5	-2.0	-1.5	-2.2	-2.1	-1.1	-1.2	-2.8	-1.0	-0.7	-2.6	-0.6
Forced vital capacity (FVC), Best measure	0.3	1.2	5.3	-0.1	-0.2	-0.1	-0.9	-0.5	0.1	-2.3	-1.4	-2.1	0.9	-0.8	-0.2
Body fat percentage	1.0	4.0	7.3	-2.2	-2.4	-2.4	-2.7	-2.5	-2.3	-0.1	-1.6	0.4	-1.5	-2.6	-1.3
Leg fat percentage (right)	1.4	5.1	8.4	-2.5	-2.8	-2.6	-2.9	-2.7	-2.6	-0.3	-1.9	0.4	-2.0	-2.9	-1.2
Arm fat-free mass (right)	0.6	3.2	6.2	-2.0	-1.7	-1.7	-2.5	-2.4	-1.7	-1.9	-1.2	-1.2	-1.3	-2.2	0.1
Exposure to tobacco smoke outside home	2.2	2.9	5.8	1.8	1.8	1.9	2.3	2.4	1.9	-0.6	2.1	-0.6	1.0	1.7	1.4
Comparative body size at age 10	0.2	0.6	2.7	0.8	1.0	0.8	1.0	0.5	0.8	-0.3	0.0	-0.3	1.6	-0.1	-0.5
Number of full brothers	3.9	4.8	8.9	-2.8	-3.0	-2.8	-2.3	-2.4	-2.6	1.0	-1.3	1.3	-1.8	-2.4	-1.4
Worry too long after embarrassment	4.7	7.8	15.6	3.4	3.7	3.3	3.9	3.6	3.1	0.1	2.6	-0.4	2.1	2.4	1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	5.6	7.3	13.7	-2.9	-3.0	-2.9	-3.2	-3.4	-2.7	-0.5	-3.5	0.2	0.1	-3.7	-2.6
Wheeze or whistling in the chest in last year	0.8	1.5	3.8	-1.4	-1.5	-1.2	-1.4	-0.9	-1.3	1.2	-0.2	1.3	-2.0	-0.5	0.5
Number of children fathered	0.2	0.3	0.7	-0.2	-0.7	-0.4	-0.5	-0.6	-0.1	-0.7	0.6	-0.5	0.1	-0.8	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	3.5	-1.3	-1.2	-1.1	-1.4	-1.4	-0.8	-0.7	-1.4	-0.3	1.1	-0.7	-1.9
Age at first live birth	0.1	0.2	0.7	-0.5	-0.3	-0.3	-0.8	-0.8	-0.4	-0.1	-0.9	0.0	0.1	0.0	-0.0
Pulse wave peak to peak time	0.2	0.2	0.9	-0.1	-0.2	-0.1	0.4	0.4	0.1	0.4	0.1	0.3	0.9	0.6	-0.8
Health satisfaction	1.5	1.9	7.6	-1.0	-1.0	-1.3	-1.4	-1.3	-1.5	1.0	-1.8	0.9	-2.8	-0.5	0.8
Shortness of breath walking on level ground	4.0	4.8	12.3	-2.2	-2.4	-2.3	-2.4	-2.3	-2.3	0.4	-2.3	0.7	-3.5	-2.7	-0.0
Qualifications: College or University degree	0.2	0.6	2.6	-0.6	-0.5	-0.3	-0.4	-0.8	-0.5	-1.3	0.0	-0.4	1.2	-0.2	-1.6
Eye problems/disorders: None of the above	1.2	1.4	7.7	-0.3	-0.5	-0.2	-0.7	-0.6	-0.2	-0.9	-0.2	-0.9	-2.1	-1.0	2.8
Mouth/teeth dental problems: Loose teeth	1.5	1.8	6.8	1.2	1.1	1.1	1.2	1.1	1.3	-1.4	1.1	-1.6	-0.3	0.0	2.6
Emphysema/chronic bronchitis	2.6	2.9	5.3	-1.9	-2.0	-2.0	-2.3	-1.9	-1.9	0.8	-1.9	1.0	-1.6	-1.8	-0.4
Medication for pain relief, constipation, heartburn	0.3	0.6	1.5	0.7	0.9	0.9	0.3	0.6	0.9	-0.9	-0.3	-0.9	1.2	-0.3	0.5
Neck or shoulder pain in last month	0.3	0.4	1.5	0.4	0.2	0.4	0.3	0.2	0.5	-0.7	0.1	-0.7	1.2	-0.3	-1.2
Medication: Blood pressure	0.1	0.2	0.7	0.1	0.2	0.0	0.2	0.1	0.0	0.5	-0.2	0.3	-0.8	0.5	0.8
Angina (self-reported)	1.2	1.6	5.0	-0.8	-0.8	-0.7	-0.3	-0.2	-1.1	2.2	-0.8	2.1	-2.2	0.9	0.4
Migraine (self-reported)	0.5	0.6	2.4	0.6	0.6	0.5	1.2	0.4	0.7	-0.8	0.8	-0.8	1.6	0.2	-0.3
Medication: Ibuprofen	0.3	0.3	1.1	0.5	0.6	0.5	0.5	0.2	0.2	0.0	0.4	-0.0	0.8	0.6	-1.1
Medication: Allopurinol	0.6	0.8	3.5	0.4	0.4	0.6	0.8	0.6	0.8	-0.8	1.3	-0.8	-0.4	0.2	1.9
Medication: Omeprazole	1.0	1.2	3.3	-1.2	-1.3	-1.2	-1.6	-1.1	-0.7	-0.5	-1.8	-0.4	-0.6	-1.2	0.5
Medication: Seretide 50 evohaler	1.3	1.5	3.3	-1.7	-1.8	-1.6	-1.3	-1.3	-1.5	-0.1	-0.7	0.5	-1.0	-0.8	-0.9
Mean time to correctly identify matches	1.6	3.0	7.5	-1.7	-1.4	-1.8	-1.6	-1.6	-1.8	1.6	-1.6	1.9	1.7	-0.9	-2.7
Heart disease (mother)	0.4	0.5	1.3	-0.5	-0.4	-0.4	-0.6	-0.5	-0.7	1.0	-0.9	1.0	-1.1	0.5	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.5	-0.1	0.2	-0.1	-0.7	-0.5	-0.2	-0.7	-0.2	-0.6	0.5	-0.5	-0.3
Whole body fat mass	0.7	2.8	5.8	-1.7	-1.9	-1.8	-2.4	-2.1	-1.7	-0.9	-1.1	-0.4	-1.3	-2.4	-0.6
Leg fat mass (right)	0.9	3.4	6.3	-2.0	-2.2	-2.1	-2.5	-2.3	-2.1	-0.8	-1.3	-0.2	-1.8	-2.5	-0.7
Arm predicted mass (right)	0.7	3.5	7.0	-2.1	-1.9	-1.8	-2.6	-2.4	-1.8	-2.0	-1.3	-1.3	-1.0	-2.5	0.2
Pulse rate, automated reading	0.3	1.1	2.6	1.3	1.2	1.1	1.6	1.4	1.2	-0.7	0.8	-0.8	0.3	0.6	0.9
Alcohol intake frequency.	0.2	0.5	1.2	0.8	1.0	0.7	0.8	0.5	0.4	1.0	0.4	0.8	0.7	1.1	-0.2
Comparative height size at age 10	0.8	4.3	8.5	2.4	2.6	2.5	2.0	2.4	2.3	0.4	2.9	-0.6	1.1	2.4	1.4
Number of full sisters	2.9	3.6	7.3	-2.0	-1.8	-2.3	-2.6	-2.5	-1.9	-0.1	-2.7	0.0	-1.2	-2.1	-0.7
Suffer from ‘nerves’	2.1	3.4	8.1	1.4	1.9	1.3	1.6	1.8	1.0	2.8	2.3	2.2	-0.8	2.4	1.2
Overall health rating	0.8	1.8	6.4	-0.4	-0.0	-0.4	-0.2	-0.1	-0.9	2.5	-0.1	2.3	-2.4	1.3	1.1
Chest pain or discomfort	1.1	1.6	2.7	-1.4	-1.6	-1.4	-1.5	-1.2	-1.4	-0.0	-1.5	0.2	-1.6	-1.2	-0.6
Had major operations	0.1	0.1	1.0	-0.2	-0.4	-0.2	-0.1	-0.2	-0.4	0.1	-0.2	0.2	-1.0	0.2	-0.2
Age at last live birth	0.2	0.3	1.4	0.2	0.1	0.3	-0.3	-0.2	0.5	-1.1	-0.0	-1.2	-0.2	-0.2	0.5
Family relationship satisfaction	1.8	2.2	4.2	-1.5	-2.0	-1.7	-1.4	-1.8	-1.6	-0.9	-1.3	-0.4	-1.7	-1.8	-1.0
Leg pain on walking	1.5	1.9	4.6	-1.5	-1.7	-1.6	-1.3	-1.3	-1.7	0.3	-1.5	0.8	-2.2	-1.3	0.5
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.5	-0.4	-0.8	-0.3	-0.4	-0.2	-0.4	-0.5	-1.2	-0.3	-0.6	-0.9	0.3
Commuting to job workplace: Car/motor vehicle	2.6	2.9	6.5	-1.6	-1.7	-1.7	-2.2	-2.0	-1.3	-1.5	-2.5	-1.5	-0.9	-2.2	-0.3
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	2.4	0.8	1.0	1.0	1.6	1.1	0.9	0.1	0.3	0.1	0.6	1.3	0.1
Medication: Aspirin	0.3	0.4	0.8	-0.6	-0.8	-0.6	-0.6	-0.4	-0.7	0.6	-0.6	0.9	-0.9	0.2	-0.0
Supplements: Vitamin C	0.3	0.3	1.3	-0.1	-0.4	-0.1	0.0	-0.1	0.1	-1.0	-0.1	-1.1	-0.8	-0.7	0.7
Knee pain experienced in last month	2.0	3.0	5.1	-2.2	-2.2	-2.1	-2.1	-1.9	-2.3	0.9	-1.0	1.5	-1.8	-0.9	-1.0
Hypertension (Self-reported)	0.2	0.5	2.3	-0.3	-0.3	-0.5	0.1	-0.2	-0.6	1.5	-0.2	1.4	-0.9	0.2	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.5	1.8	4.6	-1.2	-1.2	-1.4	-1.4	-1.4	-1.4	1.3	-1.5	1.1	-2.1	-0.8	-0.6
Illnesses of father: Heart disease	2.8	3.9	7.0	-2.2	-2.3	-2.4	-2.3	-1.8	-2.3	1.2	-2.3	1.3	-2.6	-1.0	-0.7
Illnesses of siblings: Diabetes	2.3	2.8	5.7	-1.7	-1.6	-1.8	-1.9	-2.3	-1.7	-0.3	-2.2	-0.2	0.1	-2.4	-1.6
Smoking status: Previous	1.1	1.7	4.5	1.1	0.9	0.9	0.6	0.4	1.3	-2.0	0.8	-2.0	2.1	-0.6	1.3
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.7	5.0	2.0	1.8	1.9	1.9	2.0	1.9	-1.0	2.2	-1.3	0.5	1.4	0.7
Whole body fat-free mass	0.2	1.1	3.5	-0.8	-0.5	-0.6	-1.3	-1.2	-0.6	-1.9	-0.2	-1.5	-0.6	-1.2	0.7
Leg fat-free mass (right)	0.2	0.9	3.2	-0.6	-0.4	-0.5	-1.2	-1.0	-0.5	-1.8	-0.1	-1.5	-0.6	-1.1	0.7
Arm fat percentage (left)	1.2	4.8	9.2	-2.4	-2.6	-2.5	-3.0	-2.7	-2.4	-0.5	-2.1	0.0	-1.4	-2.8	-1.5
Average weekly red wine intake	1.9	2.9	7.2	-1.7	-2.0	-1.8	-1.8	-1.9	-1.5	-2.0	-1.4	-1.0	-0.2	-2.7	-0.8
Handedness (chirality/laterality): Left-handed	1.6	1.9	6.6	1.1	1.4	1.2	1.4	1.2	1.3	-1.2	1.1	-1.4	2.6	1.1	0.7
Mood swings	0.4	0.7	1.1	0.9	0.4	1.0	1.0	1.0	1.0	-0.8	0.8	-0.9	-0.5	0.4	1.0
Loneliness, isolation	0.3	0.4	0.7	0.6	0.3	0.5	0.7	0.7	0.7	-0.4	0.8	-0.6	-0.7	-0.2	0.6
Long-standing illness, disability or infirmity	0.4	0.6	1.6	-1.0	-0.8	-0.8	-0.6	-0.6	-0.8	1.1	-0.3	1.3	-0.5	-0.4	-0.3
Ever had bowel cancer screening	1.3	1.6	3.2	-1.4	-1.5	-1.6	-1.5	-1.3	-1.2	0.2	-0.7	0.0	-0.1	-1.6	-1.8
Diabetes diagnosed by doctor	1.6	2.6	5.6	-1.6	-1.8	-1.5	-2.0	-1.7	-1.6	-0.2	-2.4	0.6	-2.0	-1.9	0.0
Ever had stillbirth, spontaneous miscarriage or termination	5.6	6.0	9.6	-2.9	-2.8	-3.0	-2.6	-2.7	-3.1	2.0	-2.1	2.5	-2.0	-1.3	-1.5
Friendships satisfaction	0.3	0.3	0.9	-0.3	-0.7	-0.3	-0.6	-0.5	-0.2	-0.8	-0.6	-0.7	0.2	-1.0	-0.3
Qualifications: nursing, teaching	0.5	0.8	3.2	0.6	0.5	0.6	0.6	0.6	0.8	-1.3	-0.2	-1.5	1.8	-0.3	-0.6
Commuting to job workplace: Walk	0.3	0.3	0.8	0.0	-0.0	0.1	0.8	0.6	-0.1	0.3	0.5	0.9	-0.9	0.9	-0.2
Eye problems/disorders: Cataract	1.2	1.4	6.1	0.6	0.9	0.4	1.0	0.9	0.4	1.0	1.1	0.9	2.0	0.7	-2.5
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	7.6	0.4	0.1	0.4	-0.3	0.0	0.8	-2.8	0.2	-2.6	1.4	-1.4	-0.2
Medication for cholesterol	0.3	0.5	0.8	0.6	0.8	0.5	0.7	0.8	0.8	-0.5	0.4	-0.9	-0.6	0.4	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	3.0	0.1	0.2	-0.2	-0.0	-0.1	-0.3	1.7	0.7	1.3	-0.7	0.9	-0.5
Back pain experienced in last month	0.5	0.8	1.5	1.1	1.2	1.2	0.6	0.9	1.1	-0.4	0.6	-0.6	0.0	1.1	1.1
Mineral and other dietary supplements	1.2	1.7	4.1	-1.5	-1.4	-1.6	-2.0	-1.5	-1.6	0.4	-1.3	0.5	-0.5	-0.5	-1.3
Breast cancer (self-reported)	0.7	0.9	1.6	-1.1	-1.0	-1.3	-1.0	-0.8	-1.2	0.3	-1.1	0.3	-1.1	0.0	-0.8
Asthma (self-reported)	2.9	5.8	10.7	-3.3	-2.7	-3.1	-2.9	-2.5	-3.1	2.2	-1.1	2.7	-1.4	-1.0	-1.3
Osteoporosis (self-reported)	0.8	0.9	2.6	1.1	0.8	1.0	1.1	1.1	1.2	0.6	1.6	-0.4	-0.4	0.9	0.8
Osteoarthritis (self-reported)	0.3	0.3	1.1	-0.1	-0.1	-0.0	0.2	-0.2	-0.3	0.9	0.8	1.1	-0.7	0.8	-0.4
Medication: Aspirin	0.6	0.7	2.4	-0.7	-0.8	-0.7	-0.6	-0.4	-0.9	1.3	-0.5	1.6	-1.1	0.5	-0.4
Medication: Gliclazide	0.4	0.5	1.2	-0.8	-1.1	-0.7	-0.9	-0.4	-0.7	-0.1	-1.1	0.3	-0.1	-0.8	0.1
Illnesses of father: None of the above (group 1)	3.6	4.4	7.1	2.2	2.0	2.4	2.6	2.2	2.7	-2.2	1.6	-2.4	1.4	0.8	1.9
Smoking status: Current	1.2	1.9	8.8	-1.1	-1.6	-1.3	-1.6	-1.1	-1.2	-0.2	-1.3	-0.3	-3.0	-1.3	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.5	3.2	7.5	-1.6	-1.8	-1.7	-2.5	-2.1	-1.3	-1.4	-2.7	-1.2	0.6	-1.9	-1.6
Whole body water mass	0.2	1.2	4.0	-0.9	-0.6	-0.6	-1.4	-1.3	-0.7	-2.0	-0.3	-1.6	-0.6	-1.3	0.7
Leg predicted mass (right)	0.2	1.1	3.2	-0.8	-0.5	-0.6	-1.4	-1.2	-0.6	-1.8	-0.3	-1.5	-0.6	-1.2	0.6
Arm fat mass (left)	1.0	4.2	8.9	-2.2	-2.4	-2.2	-3.0	-2.6	-2.1	-1.1	-1.8	-0.5	-1.2	-2.8	-1.0
Number of self-reported non-cancer illnesses	0.8	1.4	2.3	-1.1	-1.2	-1.3	-1.3	-1.2	-1.2	1.3	-1.2	1.2	-1.5	-0.8	-0.1
Average weekly champagne plus white wine intake	1.8	2.5	7.4	-1.7	-1.7	-1.9	-1.6	-1.5	-1.9	0.9	-1.4	1.1	-0.8	-0.3	-2.7
Miserableness	1.2	2.1	4.0	1.7	1.3	1.8	1.3	1.3	1.8	-1.9	0.8	-2.0	0.7	0.6	1.5
Guilty feelings	2.8	4.2	7.6	2.3	2.0	2.3	2.5	2.3	2.5	-1.2	2.1	-1.8	0.1	0.9	2.8
Wears glasses or contact lenses	0.3	0.4	2.3	0.0	0.1	-0.3	-0.1	-0.1	-0.3	1.5	0.4	1.2	-0.2	-0.0	-0.8
Ever taken oral contraceptive pill	2.2	2.5	5.2	-1.3	-1.3	-1.2	-2.2	-2.0	-1.3	-1.6	-2.3	-1.1	-1.0	-2.1	0.6
Hearing aid user	1.8	2.0	6.9	-1.1	-1.2	-1.3	-1.5	-1.9	-1.3	-0.6	-1.9	-0.2	0.3	-2.6	-1.0
Mother’s age at death	0.1	0.1	0.4	-0.2	0.1	-0.2	0.1	-0.4	-0.3	-0.6	-0.2	-0.4	0.0	0.1	-0.4
Financial situation satisfaction	1.9	2.3	9.9	-1.3	-1.7	-1.3	-1.5	-1.6	-1.4	0.2	-1.2	0.7	-3.1	-1.5	0.7
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.4	-0.5	-0.5	-0.4	-0.0	-0.2	-0.1	-0.4	0.0	0.0	-0.1	-0.1	-0.6
Commuting to job workplace: Public transport	1.6	1.9	8.1	1.1	1.5	1.5	1.4	1.1	1.2	-0.0	1.5	0.1	2.9	1.3	-0.0
Eye problems/disorders: Glaucoma	0.6	0.7	2.5	0.8	0.9	0.9	1.6	1.2	0.8	-0.1	0.6	0.1	0.5	1.0	0.2
Medication: Blood pressure	0.8	1.5	3.3	-1.3	-1.1	-1.3	-1.2	-1.2	-1.6	1.3	-1.2	1.8	-0.1	-0.3	-1.1
Pain type(s) experienced in last month: Hip pain	0.6	0.8	1.8	0.9	1.2	0.7	1.4	1.1	0.7	0.5	0.6	0.4	-0.4	0.9	1.1
Supplements: Fish oil (including cod liver oil)	0.7	1.0	2.3	1.2	1.1	1.3	1.5	1.1	1.0	0.5	1.1	0.5	-0.3	0.6	0.8
High cholesterol (Self-reported)	0.8	1.4	3.0	-0.9	-1.3	-1.1	-1.4	-1.2	-0.9	-1.2	-1.6	-0.9	-1.2	-1.7	0.4
Medication: Bendroflumethiazide	0.0	0.1	0.3	0.3	0.2	0.1	0.4	0.0	-0.0	-0.0	-0.3	0.3	0.4	-0.5	-0.0
Medication: Paracetamol	0.3	0.5	1.4	-0.0	0.1	-0.1	0.6	0.1	-0.3	1.1	1.2	1.2	-0.9	1.1	0.0
Medication: Lisinopril	0.2	0.2	1.4	0.0	0.3	0.1	0.6	-0.0	-0.1	-0.0	0.2	0.4	0.7	0.4	-1.2
Medication: Atorvastatin	0.1	0.1	0.8	-0.0	-0.2	-0.1	0.1	0.0	-0.1	-0.3	0.1	-0.1	-0.9	0.0	-0.2
Illnesses of father: High blood pressure	1.4	1.7	3.4	-1.1	-0.5	-1.1	-1.7	-1.5	-1.5	1.9	-1.2	1.8	-1.4	0.1	-0.8
Alcohol drinker status: Never	0.4	0.5	1.4	0.9	0.6	0.8	1.0	1.2	0.9	0.3	0.6	-0.1	0.7	0.6	-0.3
Ever smoked	1.0	1.8	6.0	1.3	0.8	1.0	0.6	0.8	1.4	-2.1	1.1	-2.5	0.4	-0.6	1.8
Basal metabolic rate	0.2	1.4	3.9	-1.0	-0.8	-0.8	-1.6	-1.4	-0.8	-2.0	-0.5	-1.5	-0.7	-1.5	0.6
Leg fat percentage (left)	1.6	5.8	9.7	-2.7	-3.1	-2.8	-3.1	-3.0	-2.7	-0.6	-2.2	0.2	-1.7	-3.1	-1.4
Arm fat-free mass (left)	0.5	2.6	4.8	-1.7	-1.4	-1.4	-2.2	-2.1	-1.5	-1.9	-1.3	-1.2	-0.8	-2.2	0.2
Number of operations (self-reported)	2.8	4.2	9.1	-2.0	-2.1	-2.3	-1.7	-1.7	-2.5	2.3	-1.3	2.3	-3.0	-0.2	-1.5
Average weekly beer plus cider intake	0.3	0.4	1.0	-0.7	-1.0	-0.6	-0.4	-0.7	-0.4	-0.2	-1.0	-0.1	-1.0	-0.5	-0.3
Irritability	1.3	2.2	6.3	-1.1	-1.6	-0.8	-1.9	-1.3	-0.5	-2.5	-1.1	-2.2	0.1	-1.9	0.7
Risk taking	7.1	10.3	17.7	-3.9	-3.7	-3.8	-4.1	-4.2	-3.7	0.4	-3.5	0.9	-2.3	-3.3	-1.9
Ever had prostate specific antigen (PSA) test	1.0	1.2	2.8	-1.6	-1.7	-1.5	-1.1	-1.2	-1.3	-0.8	-0.4	-0.4	-0.5	-0.8	-0.7
Fractured/broken bones in last 5 years	0.2	0.2	0.8	-0.3	-0.1	-0.3	-0.6	-0.2	-0.3	0.9	-0.2	0.7	-0.6	0.0	-0.0
Age started oral contraceptive pill	1.1	1.3	5.1	-0.2	-0.3	-0.1	-0.3	-0.4	0.2	-2.3	-0.9	-1.8	1.6	-2.0	-0.0
Diastolic blood pressure, automated reading	0.5	1.5	2.7	-1.1	-1.3	-1.4	-1.2	-1.6	-1.2	-0.5	-1.4	-0.1	-0.3	-1.7	-1.5
Ever depressed for a whole week	4.0	4.9	9.5	-2.6	-2.7	-2.6	-2.5	-2.4	-2.3	-0.6	-3.1	-0.0	-0.8	-2.9	-1.2
Unable to work because of sickness or disability	1.6	2.1	3.3	-1.5	-1.6	-1.5	-1.7	-1.5	-1.8	1.4	-1.4	1.6	-1.6	-0.5	-0.3
Commuting to job workplace: Cycle	2.1	2.5	6.4	-1.0	-1.3	-1.1	-1.6	-1.6	-0.7	-2.4	-2.5	-2.0	-0.1	-2.2	0.3
Myopia	0.3	0.4	1.4	0.1	0.5	0.2	0.3	0.3	-0.0	1.2	1.0	1.0	-0.2	1.0	-0.2
Vascular/heart problems diagnosed by doctor	0.3	0.8	3.4	0.6	0.3	0.7	0.2	0.4	0.9	-1.8	0.3	-1.8	0.9	-0.5	0.2
Cholesterol lowering medication	1.8	2.6	5.2	-1.6	-2.3	-1.7	-1.9	-1.9	-1.7	0.1	-1.7	0.6	-2.1	-1.8	-0.2
Medication: Omeprazole (e.g. Zanprol)	2.3	2.8	6.0	-2.1	-2.0	-2.0	-2.5	-1.9	-1.6	0.0	-2.4	0.2	-0.8	-1.6	-0.3
Pain experienced in last month	0.1	0.2	1.2	-0.3	-0.4	-0.3	0.1	0.1	0.1	-0.2	-0.0	-0.5	1.1	-0.2	-0.2
Supplements: Calcium	0.9	1.0	3.0	1.3	0.9	0.9	1.2	1.0	1.3	-0.5	1.7	-1.0	0.3	0.4	0.6
Basal cell carcinoma (self-reported)	0.4	0.5	1.9	-0.5	-0.3	-0.6	-0.2	-0.4	-0.6	1.0	0.8	0.7	0.4	-0.1	-1.4
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.7	-0.8	-0.2	-0.6	-0.8	-0.4	-0.8	0.5	-0.8	0.6	-0.1	0.7	-0.5
Deep venous thrombosis (DVT) (self-reported)	1.2	1.6	3.7	-1.3	-1.3	-1.2	-0.7	-1.1	-1.5	1.4	-0.5	1.9	-1.3	-0.6	-1.3
Heart disease (siblings)	1.2	1.5	3.0	-1.1	-1.4	-1.4	-1.3	-1.4	-1.4	0.7	-1.7	0.9	0.1	-1.2	-1.2
Alcohol drinker status: Previous	0.1	0.2	0.9	-0.1	0.1	-0.2	-0.1	-0.3	-0.3	0.5	-0.3	0.4	-0.9	0.1	0.5
Pack years of smoking	0.8	1.2	2.0	-1.2	-1.2	-1.2	-1.4	-1.1	-1.2	1.4	-0.9	1.0	-1.0	-0.8	0.3
Impedance of whole body	0.8	3.9	7.0	2.2	2.1	1.8	2.5	2.6	1.8	1.8	2.2	1.0	1.7	2.3	-0.6
Leg fat mass (left)	0.9	3.6	7.0	-2.0	-2.3	-2.1	-2.6	-2.4	-2.0	-1.1	-1.5	-0.5	-1.7	-2.7	-0.6
Arm predicted mass (left)	0.5	2.4	4.3	-1.6	-1.3	-1.4	-2.1	-2.0	-1.4	-1.9	-1.2	-1.3	-0.9	-2.1	0.2