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chr12:48,039,874-52,264,525

Best TWAS P=1.06e-31 · Best GWAS P=3.23e-28 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
42	GTEx	Esophagus Muscularis	CERS5	0.15	0.07	enet	18	0.09	2.7e-06	10.9	-11.7	1.1e-31	-0.88	0.04	0.96	TRUE
43	GTEx	Heart Atrial Appendage	CERS5	0.14	0.03	lasso	6	0.02	4.2e-02	-9.4	-11.5	2.2e-30	-0.85	0.05	0.91	TRUE
62	GTEx	Skin Sun Exposed Lower leg	CERS5	0.09	0.06	lasso	4	0.07	9.4e-07	10.2	-11.0	2.7e-28	-0.93	0.04	0.96	TRUE
46	GTEx	Lung	LARP4	0.07	0.05	enet	15	0.05	1.8e-04	7.1	8.3	1.0e-16	0.63	0.21	0.76	TRUE
51	GTEx	Muscle Skeletal	KANSL2	0.15	0.10	lasso	3	0.09	1.8e-09	-7.7	-7.8	4.7e-15	-0.03	0.00	1.00	TRUE
95	The Cancer Genome Atlas	Brain Lower Grade Glioma	ATF1	0.03	0.04	lasso	1	0.04	6.3e-05	-7.3	7.3	3.5e-13	0.46	0.57	0.14	TRUE
64	GTEx	Testis	DIP2B	0.14	0.08	lasso	6	0.15	3.7e-07	-2.0	6.2	5.1e-10	0.67	0.52	0.39	TRUE
92	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LETMD1	0.03	0.00	blup	44	0.02	3.8e-03	6.6	-5.9	4.0e-09	-0.27	0.01	0.35	TRUE
80	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	DIP2B	0.22	0.05	enet	13	0.06	6.2e-06	9.0	5.4	8.0e-08	0.53	0.20	0.73	TRUE
69	GTEx	Thyroid	CERS5	0.09	0.04	lasso	9	0.04	3.7e-04	10.2	-11.3	1.4e-29	-0.85	0.11	0.88	FALSE
54	GTEx	Nerve Tibial	CERS5	0.31	0.28	enet	20	0.36	2.2e-26	-9.4	-11.0	3.1e-28	-0.73	1.00	0.00	FALSE
20	GTEx	Brain Cerebellum	CERS5	0.53	0.65	enet	19	0.65	6.0e-25	9.9	-10.9	8.4e-28	-0.80	0.93	0.07	FALSE
8	GTEx	Adrenal Gland	DIP2B	0.16	0.05	lasso	9	0.07	2.1e-03	10.3	10.9	9.5e-28	0.93	0.04	0.83	FALSE
60	GTEx	Skin Not Sun Exposed Suprapubic	COX14	0.17	0.04	lasso	5	0.03	5.4e-03	9.8	10.9	1.3e-27	0.86	0.05	0.83	FALSE
81	The Cancer Genome Atlas	Breast Invasive Carcinoma	C12orf62	0.01	0.00	blup	47	0.00	4.6e-02	9.8	10.8	3.5e-27	0.76	0.01	0.72	FALSE
61	GTEx	Skin Sun Exposed Lower leg	ATF1	0.07	0.07	lasso	4	0.08	6.1e-07	10.5	10.8	3.6e-27	0.96	0.03	0.96	FALSE
17	GTEx	Brain Caudate basal ganglia	CERS5	0.37	0.21	lasso	16	0.21	9.7e-07	8.6	-10.7	1.0e-26	-0.72	0.31	0.66	FALSE
78	YFS	Blood	LIMA1	0.04	0.06	enet	31	0.06	3.5e-19	10.7	10.6	2.0e-26	0.89	0.04	0.96	FALSE
52	GTEx	Muscle Skeletal	COX14	0.05	0.03	lasso	11	0.02	5.7e-03	9.9	10.6	2.1e-26	0.84	0.12	0.86	FALSE
109	The Cancer Genome Atlas	Thyroid Carcinoma	C12orf62	0.06	0.02	blup	47	0.05	1.8e-05	8.7	10.6	2.4e-26	0.71	0.02	0.97	FALSE
49	GTEx	Muscle Skeletal	ATF1	0.09	0.06	lasso	5	0.07	5.0e-07	10.1	10.5	5.2e-26	0.86	0.66	0.33	FALSE
88	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C12orf62	0.02	0.01	blup	47	0.01	1.7e-02	10.1	10.5	7.5e-26	0.75	0.01	0.78	FALSE
107	The Cancer Genome Atlas	Testicular Germ Cell Tumors	DIP2B	0.11	0.02	blup	79	0.02	4.5e-02	10.4	10.5	7.5e-26	0.92	0.01	0.88	FALSE
28	GTEx	Breast Mammary Tissue (Female)	ATF1	0.04	0.03	enet	7	0.00	2.7e-01	10.5	10.5	7.9e-26	0.84	0.03	0.27	FALSE
25	GTEx	Brain Putamen basal ganglia	CERS5	0.29	0.12	enet	36	0.21	1.2e-05	-8.4	-10.5	1.1e-25	-0.77	0.05	0.89	FALSE
4	GTEx	Adipose Subcutaneous	ATF1	0.07	0.05	enet	14	0.04	3.1e-04	10.1	10.4	2.4e-25	0.84	0.30	0.68	FALSE
27	GTEx	Breast Mammary Tissue	CERS5	0.05	0.06	lasso	2	0.04	6.1e-03	10.2	-10.3	5.8e-25	-0.84	0.07	0.78	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CERS5	0.09	0.13	lasso	9	0.12	7.9e-14	9.8	10.3	5.9e-25	0.81	0.84	0.16	FALSE
18	GTEx	Brain Cerebellar Hemisphere	CERS5	0.50	0.38	lasso	9	0.38	1.1e-10	9.9	-10.3	6.2e-25	-0.79	0.44	0.56	FALSE
5	GTEx	Adipose Subcutaneous	CERS5	0.05	0.08	lasso	2	0.07	3.2e-06	10.1	-10.3	7.9e-25	-0.76	0.49	0.48	FALSE
59	GTEx	Skin Not Sun Exposed Suprapubic	CERS5	0.14	0.16	lasso	2	0.15	8.3e-09	10.0	-10.3	8.2e-25	-0.80	0.76	0.24	FALSE
48	GTEx	Muscle Skeletal	DIP2B	0.03	0.04	lasso	6	0.04	1.1e-04	10.1	10.3	9.7e-25	0.83	0.21	0.76	FALSE
45	GTEx	Lung	CERS5	0.07	0.06	enet	12	0.07	2.8e-06	10.1	-10.2	1.4e-24	-0.86	0.06	0.94	FALSE
11	GTEx	Artery Coronary	ATF1	0.20	0.09	lasso	4	0.05	1.2e-02	10.1	10.2	1.7e-24	0.84	0.09	0.66	FALSE
31	GTEx	Cells Transformed fibroblasts	DIP2B	0.16	0.08	lasso	3	0.08	6.2e-07	9.0	10.2	2.3e-24	0.89	0.25	0.74	FALSE
41	GTEx	Esophagus Muscularis	ATF1	0.15	0.17	lasso	2	0.16	7.5e-10	10.1	10.2	2.3e-24	0.83	0.91	0.09	FALSE
9	GTEx	Artery Aorta	ATF1	0.26	0.29	lasso	2	0.28	1.5e-15	10.1	10.2	3.1e-24	0.83	0.98	0.02	FALSE
57	GTEx	Ovary	CERS5	0.22	0.02	lasso	4	0.03	7.9e-02	10.2	-10.2	3.1e-24	-0.83	0.04	0.68	FALSE
10	GTEx	Artery Aorta	CERS5	0.19	0.00	lasso	7	0.01	1.0e-01	10.1	-10.2	3.2e-24	-0.85	0.07	0.84	FALSE
58	GTEx	Prostate	CERS5	0.19	0.08	lasso	4	0.02	1.2e-01	-9.4	-10.1	4.0e-24	-0.66	0.06	0.38	FALSE
97	The Cancer Genome Atlas	Brain Lower Grade Glioma	C12orf62	0.05	0.05	enet	8	0.06	6.1e-07	8.7	10.1	4.7e-24	0.69	0.03	0.97	FALSE
98	The Cancer Genome Atlas	Brain Lower Grade Glioma	FAM186A	0.03	0.03	lasso	6	0.02	2.2e-03	10.8	-10.1	5.5e-24	-0.87	0.02	0.76	FALSE
2	CommonMind	Brain Pre-frontal Cortex	DIP2B	0.11	0.10	enet	16	0.13	2.6e-15	-8.4	-10.1	6.9e-24	-0.69	1.00	0.00	FALSE
91	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C12orf62	0.03	0.04	lasso	2	0.03	1.8e-04	10.0	10.1	7.2e-24	0.76	0.01	0.99	FALSE
13	GTEx	Artery Tibial	ATF1	0.24	0.26	lasso	7	0.25	2.7e-19	10.1	10.1	7.4e-24	0.84	0.99	0.01	FALSE
38	GTEx	Esophagus Gastroesophageal Junction	ATF1	0.15	0.15	lasso	4	0.14	7.8e-06	10.0	10.0	2.1e-23	0.79	0.07	0.90	FALSE
94	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C12orf62	0.08	0.01	blup	47	0.06	3.2e-04	9.8	9.9	3.3e-23	0.71	0.01	0.98	FALSE
22	GTEx	Brain Frontal Cortex BA9	CERS5	0.27	0.11	lasso	3	0.07	8.2e-03	9.9	-9.9	3.8e-23	-0.74	0.12	0.60	FALSE
21	GTEx	Brain Cortex	CERS5	0.26	0.09	enet	30	0.11	5.9e-04	10.1	-9.9	4.7e-23	-0.73	0.06	0.80	FALSE
36	GTEx	Cells Transformed fibroblasts	COX14	0.09	0.11	lasso	6	0.09	4.3e-07	9.8	9.8	1.0e-22	0.74	0.99	0.01	FALSE
15	GTEx	Artery Tibial	RP4-605O3.4	0.04	0.01	lasso	4	0.00	3.2e-01	-9.4	-9.8	1.2e-22	-0.62	0.14	0.45	FALSE
37	GTEx	Colon Sigmoid	COX14	0.25	0.21	enet	13	0.22	3.9e-08	9.9	9.8	1.2e-22	0.68	0.81	0.07	FALSE
23	GTEx	Brain Hippocampus	CERS5	0.31	0.21	lasso	4	0.22	5.9e-06	10.2	-9.7	2.6e-22	-0.76	0.16	0.54	FALSE
70	GTEx	Thyroid	COX14	0.11	0.10	lasso	2	0.08	1.4e-06	9.8	9.6	7.2e-22	0.72	0.86	0.11	FALSE
63	GTEx	Stomach	DIP2B	0.09	0.09	lasso	5	0.07	4.1e-04	9.0	9.6	8.3e-22	0.83	0.11	0.45	FALSE
67	GTEx	Testis	CERS5	0.12	0.06	lasso	6	0.07	4.0e-04	-9.3	-9.6	1.1e-21	-0.60	0.15	0.26	FALSE
85	The Cancer Genome Atlas	Colon Adenocarcinoma	ATF1	0.10	0.05	enet	18	0.06	3.5e-04	10.1	9.5	1.5e-21	0.79	0.03	0.96	FALSE
77	YFS	Blood	DIP2B	0.36	0.27	bslmm	385	0.28	2.8e-90	9.0	-9.5	2.0e-21	-0.80	1.00	0.00	FALSE
86	The Cancer Genome Atlas	Colon Adenocarcinoma	DIP2B	0.13	0.14	lasso	2	0.12	1.3e-07	9.1	9.5	2.2e-21	0.84	0.05	0.95	FALSE
104	The Cancer Genome Atlas	Prostate Adenocarcinoma	C12orf62	0.03	0.03	enet	15	0.03	1.1e-03	9.8	9.5	2.5e-21	0.70	0.01	0.90	FALSE
71	GTEx	Whole Blood	DIP2B	0.12	0.08	lasso	4	0.08	5.7e-08	9.0	9.5	2.6e-21	0.82	0.90	0.08	FALSE
73	GTEx	Whole Blood	RP4-605O3.4	0.04	0.04	lasso	4	0.01	1.5e-02	-9.4	-9.4	4.4e-21	-0.56	0.27	0.06	FALSE
24	GTEx	Brain Hypothalamus	CERS5	0.19	0.12	lasso	8	0.10	2.1e-03	8.1	-9.3	9.4e-21	-0.68	0.10	0.32	FALSE
33	GTEx	Cells Transformed fibroblasts	ASIC1	0.15	0.12	lasso	4	0.11	1.3e-08	8.7	-9.2	2.8e-20	-0.67	0.95	0.04	FALSE
19	GTEx	Brain Cerebellar Hemisphere	RP4-605O3.4	0.18	0.12	enet	14	0.10	1.5e-03	-9.3	-9.2	3.5e-20	-0.61	0.12	0.26	FALSE
7	GTEx	Adipose Visceral Omentum	CERS5	0.10	0.01	enet	11	0.01	1.3e-01	10.9	-9.1	6.3e-20	-0.87	0.04	0.74	FALSE
100	The Cancer Genome Atlas	Lung Adenocarcinoma	DIP2B	0.09	0.02	enet	9	0.05	1.3e-06	9.1	9.1	6.5e-20	0.74	0.01	0.98	FALSE
55	GTEx	Nerve Tibial	COX14	0.14	0.09	lasso	6	0.07	1.1e-05	9.9	9.1	7.6e-20	0.67	0.89	0.06	FALSE
16	GTEx	Brain Caudate basal ganglia	LIMA1	0.18	0.12	lasso	5	0.07	3.9e-03	-8.5	-9.0	1.9e-19	-0.60	0.12	0.28	FALSE
26	GTEx	Breast Mammary Tissue	ATF1	0.07	0.07	lasso	5	0.04	2.9e-03	10.5	8.9	5.7e-19	0.88	0.08	0.58	FALSE
93	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LIMA1	0.08	0.10	blup	59	0.10	1.8e-11	-9.0	8.8	1.2e-18	0.63	1.00	0.00	FALSE
76	YFS	Blood	ATF1	0.05	0.07	lasso	9	0.07	2.0e-21	-7.3	-8.7	2.3e-18	-0.59	1.00	0.00	FALSE
103	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	ACCN2	0.04	0.03	enet	7	0.02	9.8e-03	9.8	-8.7	2.6e-18	-0.63	0.01	0.78	FALSE
32	GTEx	Cells Transformed fibroblasts	SMARCD1	0.08	0.07	enet	5	0.07	9.3e-06	-8.4	8.5	1.4e-17	0.57	0.98	0.01	FALSE
74	METSIM	Adipose	CERS5	0.04	0.03	bslmm	306	0.04	1.1e-06	9.8	-8.5	1.4e-17	-0.67	0.42	0.56	FALSE
65	GTEx	Testis	SMARCD1	0.22	0.10	enet	22	0.10	2.6e-05	-8.6	8.5	1.7e-17	0.48	0.74	0.03	FALSE
39	GTEx	Esophagus Mucosa	DIP2B	0.08	0.03	enet	30	0.03	4.0e-03	10.2	8.5	1.8e-17	0.68	0.08	0.44	FALSE
84	The Cancer Genome Atlas	Breast Invasive Carcinoma	SMARCD1	0.02	0.03	lasso	1	0.03	3.7e-06	-8.5	8.5	2.7e-17	0.56	0.80	0.02	FALSE
99	The Cancer Genome Atlas	Lung Adenocarcinoma	ACCN2	0.03	0.03	blup	47	0.02	1.0e-03	8.1	-8.4	3.4e-17	-0.58	0.02	0.71	FALSE
68	GTEx	Thyroid	LIMA1	0.08	0.06	enet	18	0.06	1.7e-05	-9.0	-8.0	1.5e-15	-0.63	0.08	0.76	FALSE
35	GTEx	Cells Transformed fibroblasts	LARP4	0.21	0.24	lasso	6	0.22	1.4e-16	7.1	7.7	1.5e-14	0.63	1.00	0.00	FALSE
75	NTR	Blood	ATF1	0.06	0.07	enet	35	0.07	4.0e-21	-7.2	-7.6	2.1e-14	-0.47	1.00	0.00	FALSE
29	GTEx	Breast Mammary Tissue (Female)	CERS5	0.09	0.03	lasso	3	0.05	1.8e-02	10.2	-7.6	2.3e-14	-0.58	0.05	0.26	FALSE
40	GTEx	Esophagus Mucosa	CERS5	0.08	0.00	enet	23	0.01	6.4e-02	10.9	-7.6	2.3e-14	-0.63	0.04	0.87	FALSE
66	GTEx	Testis	SLC11A2	0.17	0.13	enet	11	0.12	9.2e-06	4.9	7.5	4.3e-14	0.44	0.88	0.01	FALSE
108	The Cancer Genome Atlas	Thyroid Carcinoma	C12orf41	0.09	0.06	lasso	3	0.07	4.3e-07	-7.3	7.5	6.9e-14	0.03	0.00	1.00	FALSE
102	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	LETMD1	0.03	0.02	lasso	4	0.02	1.9e-03	6.0	-7.3	2.4e-13	-0.30	0.02	0.78	FALSE
89	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	DIP2B	0.06	0.01	blup	79	0.02	9.4e-04	9.1	7.3	3.5e-13	0.78	0.01	0.95	FALSE
44	GTEx	Heart Atrial Appendage	COX14	0.18	0.01	lasso	7	0.01	6.9e-02	1.1	7.2	4.5e-13	0.41	0.08	0.14	FALSE
79	YFS	Blood	SLC11A2	0.07	0.04	lasso	7	0.06	4.2e-18	6.5	7.1	1.1e-12	0.27	1.00	0.00	FALSE
30	GTEx	Cells Transformed fibroblasts	LIMA1	0.17	0.01	lasso	6	0.02	8.8e-03	7.1	7.1	1.7e-12	0.62	0.11	0.29	FALSE
83	The Cancer Genome Atlas	Breast Invasive Carcinoma	SLC11A2	0.03	0.02	blup	69	0.02	3.0e-04	6.4	6.9	7.0e-12	0.29	0.02	0.98	FALSE
105	The Cancer Genome Atlas	Prostate Adenocarcinoma	LETMD1	0.03	0.03	blup	44	0.02	7.4e-03	6.5	-6.7	1.6e-11	-0.33	0.01	0.82	FALSE
6	GTEx	Adipose Subcutaneous	RACGAP1	0.19	0.10	lasso	6	0.10	1.6e-08	4.7	6.7	1.8e-11	0.51	0.96	0.03	FALSE
90	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	LETMD1	0.05	0.04	enet	3	0.04	8.2e-06	6.4	-6.7	2.3e-11	-0.23	0.02	0.98	FALSE
14	GTEx	Artery Tibial	KANSL2	0.24	0.15	lasso	3	0.18	4.6e-14	4.4	6.7	2.5e-11	0.00	0.39	0.61	FALSE
96	The Cancer Genome Atlas	Brain Lower Grade Glioma	C12orf41	0.13	0.03	blup	37	0.03	3.9e-04	-7.7	6.6	4.5e-11	-0.01	0.00	0.99	FALSE
50	GTEx	Muscle Skeletal	TFCP2	0.05	0.01	lasso	2	0.00	1.2e-01	6.5	6.5	8.9e-11	0.26	0.57	0.01	FALSE
82	The Cancer Genome Atlas	Breast Invasive Carcinoma	LETMD1	0.02	0.01	blup	44	0.01	4.4e-03	5.7	-6.5	1.1e-10	-0.22	0.05	0.58	FALSE
106	The Cancer Genome Atlas	Rectum Adenocarcinoma	SMARCD1	0.40	0.04	blup	48	0.14	4.1e-04	-8.5	6.4	1.9e-10	0.34	0.04	0.11	FALSE
56	GTEx	Nerve Tibial	RP4-605O3.4	0.11	0.00	lasso	3	0.00	1.7e-01	-9.4	-6.0	2.1e-09	-0.31	0.16	0.03	FALSE
12	GTEx	Artery Tibial	LIMA1	0.20	0.04	lasso	4	0.08	5.7e-07	4.2	-6.0	2.7e-09	-0.45	0.46	0.20	FALSE
72	GTEx	Whole Blood	ATF1	0.07	0.09	lasso	4	0.07	3.5e-07	-6.0	-6.0	2.7e-09	-0.44	1.00	0.00	FALSE
87	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C12orf41	0.05	0.02	blup	37	0.03	3.1e-04	4.2	5.8	5.7e-09	-0.01	0.10	0.74	FALSE
101	The Cancer Genome Atlas	Lung Adenocarcinoma	SLC11A2	0.03	0.02	blup	69	0.02	5.7e-03	6.4	5.8	8.8e-09	0.30	0.02	0.77	FALSE
47	GTEx	Muscle Skeletal	LETMD1	0.10	0.07	enet	6	0.07	9.4e-08	6.5	-5.7	1.2e-08	-0.24	1.00	0.00	FALSE
34	GTEx	Cells Transformed fibroblasts	SLC11A2	0.47	0.34	enet	46	0.43	4.6e-35	6.4	5.6	2.7e-08	0.24	1.00	0.00	FALSE
53	GTEx	Nerve Tibial	KANSL2	0.33	0.26	lasso	4	0.30	1.8e-21	4.2	5.5	4.1e-08	0.01	1.00	0.00	FALSE
3	CommonMind	Brain Pre-frontal Cortex	ZNF641	0.03	0.01	blup	489	0.02	6.4e-04	1.9	5.3	1.3e-07	-0.01	0.50	0.04	FALSE