TWAS hub - LARP4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.2140	0.0580	2.7e-11	0.244	NA	0.206	NA	0.222	2.5e-18	NA	2.3e-15	NA	1.4e-16
2	GTEx	Lung	0.0683	0.0325	3.5e-04	0.047	NA	0.046	NA	0.044	1.5e-04	NA	1.8e-04	NA	2.7e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Serious illness, injury or assault of a close relative in last 2 years	8.9	10.2	10.7	3.1	3.3
Blood White Count	8.6	64.0	68.9	7.7	8.3
Hair/balding pattern: Pattern 4	8.2	19.8	23.4	4.0	4.8
Heel T-Score	7.0	55.5	62.1	-7.0	-7.9
Chest pain or discomfort	6.3	9.1	11.7	2.6	3.4
Lung FVC	6.1	31.0	34.1	5.3	5.8
Serious illness, injury or assault to yourself	5.3	6.4	8.3	2.1	2.9
Blood Platelet Count	5.1	59.6	81.4	6.2	9.0
Reason for reducing amount of alcohol drunk: Health precaution	5.1	6.0	6.1	-2.5	-2.4
Medication: Lansoprazole	4.9	5.6	6.9	2.1	2.6
Impedance of whole body	4.9	25.0	32.0	-4.2	-5.7
Trunk fat percentage	4.8	19.3	28.6	-3.2	-5.3
Impedance of leg (left)	4.8	23.3	30.0	-4.1	-5.5
Reaction Time	4.6	8.7	9.6	-3.1	-2.8
High cholesterol (Self-reported)	4.6	8.2	10.2	3.2	2.5
Medication: Atorvastatin	4.6	5.7	6.0	2.5	2.3
Current tobacco smoking	4.5	7.4	10.5	2.1	3.2
Ever had hysterectomy (womb removed)	4.4	5.0	5.4	-2.1	-2.3
Medication: Co-codamol	4.3	5.0	5.3	2.3	2.2
Diastolic blood pressure, automated reading	4.3	13.4	19.6	-2.7	-4.4
Primary Biliary Cirrhosis	4.2	6.0	7.5	-2.1	-2.7
Smoking status: Current	4.1	6.4	9.5	1.8	3.1
Heel bone mineral density (BMD) T-score, automated (right)	4.0	9.2	9.8	-3.1	-2.9
Mean time to correctly identify matches	4.0	7.6	7.7	-2.7	-2.8
Impedance of leg (right)	3.9	18.8	25.0	-3.5	-5.0
Crohns Disease (2012)	3.7	5.9	6.8	2.2	2.6
Fractured/broken bones in last 5 years	3.7	4.7	6.0	2.4	1.9
Prospective memory result	3.6	4.5	5.0	2.2	2.0
Body fat percentage	3.6	14.1	20.9	-2.7	-4.6
Medication: Aspirin	3.6	4.7	5.8	2.4	1.9
Mother’s age at death	3.4	4.2	4.4	-2.0	-2.1
Impedance of arm (right)	3.3	15.4	20.7	-3.2	-4.5
Hand grip strength (left)	3.2	8.5	10.1	3.2	2.6
Chronic bronchitis/emphysema (father)	3.2	3.7	5.2	-1.5	-2.3
Medication: Aspirin	3.2	4.2	5.0	2.2	1.9
Hearing aid user	3.2	3.6	5.5	-2.3	-1.3
Ever had prostate specific antigen (PSA) test	3.2	3.7	4.0	1.8	2.0
Trunk fat mass	3.1	13.4	20.7	-2.5	-4.5
Father’s age at death	3.1	4.2	6.3	-2.5	-1.4
Hair/balding pattern: Pattern 3	3.1	4.6	6.5	1.6	2.5
Systolic blood pressure, automated reading	2.9	8.4	13.7	-1.8	-3.7
Bilateral oophorectomy (both ovaries removed)	2.9	3.4	3.9	-1.7	-2.0
Qualifications: O levels/GCSEs or equivalent	2.9	4.5	4.7	2.1	2.2
Emphysema/chronic bronchitis	2.9	3.3	4.4	2.1	1.4
Osteoarthritis (self-reported)	2.9	3.7	5.3	1.5	2.3
Cholesterol lowering medication	2.9	4.2	5.4	1.8	2.3
Heel bone mineral density (BMD) T-score, automated (left)	2.8	6.3	7.3	-2.3	-2.7
Impedance of arm (left)	2.7	12.6	16.9	-2.9	-4.1
Medication: Cholesterol lowering	2.6	4.0	6.2	2.5	1.4
Illnesses of mother	2.6	3.3	4.4	1.5	2.1
Alcohol drinker status: Previous	2.6	2.9	3.1	-1.6	-1.8
Hand grip strength (right)	2.5	6.8	9.7	3.1	2.0
Alcohol usually taken with meals	2.5	4.0	4.2	2.1	1.9
Qualifications: A levels/AS levels or equivalent	2.5	5.5	5.8	2.3	2.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.5	5.2	5.4	2.3	2.3
Supplements: Calcium	2.5	2.7	3.1	-1.5	-1.8
Number of full brothers	2.4	3.0	4.0	-2.0	-1.4
Medication: Simvastatin	2.3	3.3	4.2	2.1	1.6
Pulse wave reflection index	2.3	2.9	3.3	-1.5	-1.8
Medication: Omeprazole (e.g. Zanprol)	2.3	2.8	2.8	1.7	1.7
Hayfever/allergic rhinitis (self-reported)	2.2	2.9	4.2	2.0	1.3
Illnesses of siblings	2.2	3.2	3.8	1.6	2.0
Medication: Omeprazole	2.2	2.7	2.9	1.7	1.5
Eye problems/disorders: Cataract	2.2	2.6	3.8	-1.2	-2.0
Osteoporosis (self-reported)	2.2	2.7	2.8	1.6	1.7
Heart disease (siblings)	2.2	2.7	4.5	-2.1	-0.9
Blood Red Count	2.1	19.9	20.3	-4.5	-4.4
Medication: Amlodipine	2.1	2.9	4.7	-1.0	-2.2
Worry too long after embarrassment	2.1	3.5	4.8	1.5	2.2
Angina (self-reported)	2.1	2.7	3.0	1.6	1.7
Whole body fat mass	2.1	8.9	13.7	-2.0	-3.7
Had major operations	2.1	2.5	3.1	1.8	1.3
Leg fat percentage (left)	2.1	7.7	11.3	-2.0	-3.4
Angina	2.0	2.6	2.9	1.5	1.7
Qualifications: None of the above	2.0	4.4	6.0	-2.5	-1.6
Medication: Ramipril	2.0	2.5	2.9	1.7	1.5
Illnesses of father: High blood pressure	2.0	2.4	3.3	-1.2	-1.8
Intelligence (Savage-Jansen 2018)	1.9	5.9	5.9	2.4	2.4
Relative age voice broke	1.9	2.9	3.9	1.4	2.0
Tinnitus: Yes, but not now, but have in the past	1.9	2.0	2.6	1.2	1.6
Medication for pain relief, constipation, heartburn	1.9	3.2	3.4	-1.8	-1.9
Illnesses of father: Heart disease	1.9	2.6	2.8	1.7	1.5
Systolic Blood Pressure	1.8	9.2	16.2	-1.4	-4.0
Sitting height	1.8	12.9	18.7	-2.7	-4.3
Leg fat percentage (right)	1.8	6.6	10.0	-1.8	-3.2
Neck or shoulder pain in last month	1.8	2.5	3.2	1.8	1.3
Qualifications: nursing, teaching	1.8	2.8	4.3	1.1	2.1
Medication: Bendroflumethiazide	1.8	2.7	3.2	1.8	1.5
Average weekly beer plus cider intake	1.8	2.6	2.9	-1.5	-1.7
Bipolar Disorder or Schizophrenia	1.7	4.1	5.9	-1.5	-2.4
Lupus	1.7	2.6	3.4	-1.4	-1.9
Type 2 Diabetes (T2D) (2018)	1.7	3.2	4.8	2.2	1.2
Average weekly fortified wine intake	1.7	2.0	2.1	1.4	1.4
Diabetes (self-reported)	1.7	2.6	4.0	2.0	1.1
Pulse wave Arterial Stiffness index	1.7	2.0	2.9	-1.1	-1.7
Gout (self-reported)	1.7	2.3	2.4	-1.5	-1.5
Guilty feelings	1.7	2.6	4.3	1.0	2.1
Alcohol drinker status: Never	1.7	2.0	2.6	1.6	1.2
Bipolar Disorder (2011)	1.6	1.5	2.4	-0.8	-1.5
Schizophrenia (2014)	1.6	3.5	5.0	-1.4	-2.2
Headache pain in last month	1.6	2.8	3.0	1.6	1.7
Bipolar Disorder (2018)	1.5	2.4	3.3	-1.2	-1.8
Schizophrenia vs Biploar Disorder	1.5	2.0	2.2	-1.3	-1.5
Arm fat percentage (right)	1.5	5.8	8.9	-1.6	-3.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.8	3.0	-1.7	-0.9
Wears glasses or contact lenses	1.5	1.7	2.0	-1.4	-1.2
Leg fat mass (right)	1.4	5.4	8.9	-1.4	-3.0
Leg fat mass (left)	1.4	5.6	9.0	-1.5	-3.0
Hearing difficulty/problems: Yes	1.3	2.0	2.2	-1.3	-1.5
Ever used hormone-replacement therapy (HRT)	1.3	1.7	2.5	-1.6	-0.9
Taking other prescription medications	1.3	2.0	2.0	1.4	1.4
Ever unenthusiastic/disinterested for a whole week	1.3	1.6	2.5	0.9	1.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.1	4.8	2.2	1.8
Birth weight of first child	1.3	2.4	4.7	0.2	2.2
Handedness (chirality/laterality): Left-handed	1.3	1.5	1.7	-1.2	-1.3
Severe depression (siblings)	1.2	1.3	2.3	0.6	1.5
Fed-up feelings	1.2	2.2	3.8	0.7	2.0
Qualifications: College or University degree	1.2	3.8	4.3	1.8	2.1
Leg pain on walking	1.2	1.5	2.0	0.9	1.4
Mouth/teeth dental problems: Mouth ulcers	1.2	1.9	3.7	0.1	1.9
Alzheimer’s Disease (including proxy)	1.1	1.6	2.5	-0.8	-1.6
Crohns Disease (2017)	1.1	2.5	3.9	1.0	2.0
Average weekly spirits intake	1.1	1.3	1.6	1.0	1.3
Multivitamins +/- minerals	1.1	1.4	2.8	-0.2	-1.7
Had menopause	1.1	1.3	1.6	1.3	1.0
Financial difficulties in last 2 years	1.1	1.5	2.1	-1.5	-0.9
Hip circumference	1.1	4.9	8.9	-1.0	-3.0
Standing height	1.1	11.3	17.9	-2.2	-4.2
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	2.0	-1.4	-1.0
Heart disease (mother)	1.1	1.3	1.8	0.9	1.4
Arm fat percentage (left)	1.1	4.3	6.7	-1.4	-2.6
Medication: Gliclazide	1.1	1.2	1.5	1.0	1.2
Miserableness	1.1	2.0	3.2	0.9	1.8
Height	1.0	18.6	30.7	-2.6	-5.5
Relative age of first facial hair	1.0	2.0	3.0	1.0	1.7
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	1.2	-1.0	-1.1
High blood pressure (mother)	1.0	1.3	2.5	-0.4	-1.6
Heart attack	1.0	1.3	2.2	0.6	1.5
Neuroticism score	1.0	2.1	3.4	0.9	1.8
Forced expiratory volume in 1-second (FEV1)	1.0	3.5	5.2	2.3	1.4
Arm fat mass (right)	1.0	4.3	7.0	-1.3	-2.6
Peak expiratory flow (PEF)	1.0	2.3	4.5	2.1	0.0
Medication: Allopurinol	1.0	1.3	1.5	-1.1	-1.2
Suffer from ‘nerves’	1.0	1.6	2.1	1.4	1.0
Heart attack/myocardial infarction (self-reported)	1.0	1.3	2.2	0.6	1.5
Verbal and Numeric Reasoning (VNR)	0.9	2.2	3.6	0.9	1.9
HbA1C	0.9	1.0	1.1	0.9	1.1
Townsend deprivation index at recruitment	0.9	1.3	2.1	-1.4	-0.6
Medication: Atenolol	0.9	1.1	1.8	-0.6	-1.3
Number of incorrect matches in round	0.9	1.5	1.6	-1.3	-1.2
Hearing difficulty/problems with background noise	0.9	1.4	1.9	1.4	0.9
Alcohol intake versus 10 years previously	0.9	1.4	1.5	-1.1	-1.2
Exposure to tobacco smoke at home	0.9	1.1	1.7	-0.6	-1.3
Forced vital capacity (FVC), Best measure	0.9	3.4	4.5	2.1	1.5
Pulse wave peak to peak time	0.9	1.0	1.6	0.7	1.2
Comparative height size at age 10	0.9	4.9	8.6	-1.1	-2.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	1.6	1.3	0.7
Diabetes diagnosed by doctor	0.9	1.4	2.4	1.6	0.6
Arm fat mass (left)	0.9	3.5	5.9	-1.1	-2.4
Eye problems/disorders: Glaucoma	0.9	1.1	1.3	1.1	0.9
Schizophrenia (2018)	0.8	1.6	2.3	-1.0	-1.5
Age at First Birth	0.8	1.2	1.9	-0.7	-1.4
Coronary Artery Disease (CAD)	0.8	0.9	1.0	0.9	1.0
Allergy or Eczema	0.8	2.1	2.8	1.7	1.1
Chronotype (morning person)	0.8	1.8	2.7	-0.9	-1.6
Number of treatments/medications taken	0.8	1.5	2.0	1.4	0.9
Hypothyroidism/myxoedema (self-reported)	0.8	1.5	1.7	1.3	1.1
Shortness of breath walking on level ground	0.8	1.0	1.9	0.1	1.4
LDL Cholesterol	0.7	1.2	1.9	0.7	1.4
Blood Eosinophil Count	0.7	5.4	7.7	1.8	2.8
Smoking Status	0.7	1.6	2.6	0.8	1.6
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.1	0.9	1.1
Forced vital capacity (FVC)	0.7	2.5	3.5	1.9	1.2
Weight	0.7	3.2	5.8	-0.8	-2.4
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	2.0	-1.4	-0.6
Depression (self-reported)	0.7	0.8	1.1	0.8	1.0
Loud music exposure frequency	0.7	0.8	1.5	0.2	1.2
Average weekly champagne plus white wine intake	0.7	1.0	1.7	-1.3	-0.5
Depressed Affect (Nagel 2018)	0.6	1.3	2.4	0.5	1.5
Respiratory disease	0.6	1.3	1.7	-1.0	-1.3
Medication for hormone replacement therapy	0.6	0.7	1.1	-0.6	-1.1
Vitamin and mineral supplements	0.6	0.8	1.6	-0.3	1.2
Diabetes (mother)	0.6	0.8	1.0	-1.0	-0.7
Breastfed as a baby	0.6	0.8	1.5	-0.2	-1.2
High blood pressure (siblings)	0.6	0.9	1.8	-0.1	-1.3
Exposure to tobacco smoke outside home	0.6	0.8	1.6	-1.3	-0.3
Health satisfaction	0.6	0.8	1.1	0.7	1.1
Medication: Ibuprofen	0.6	0.7	0.9	0.8	0.9
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.4	-1.2	-0.3
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.3	-0.4	-1.1
Hypertension (Self-reported)	0.6	1.6	3.1	0.1	-1.8
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	0.7	0.8	0.8
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	0.9	0.8	1.0
Alzheimer’s Disease (in mother)	0.5	0.6	1.1	-0.3	-1.1
Irritable Bowel Disease (IBD)	0.5	1.3	2.6	0.1	1.6
Neuroticism (2016)	0.5	0.8	1.0	0.7	1.0
Ulcerative Colitis	0.5	0.7	1.2	0.5	1.1
Neuroticism	0.5	1.2	2.2	0.4	1.5
Diabetes (father)	0.5	0.6	0.7	0.8	0.7
Hayfever, allergic rhinitis or eczema	0.5	1.1	1.2	1.1	1.0
Happiness	0.5	0.6	0.7	0.8	0.7
Glaucoma (self-reported)	0.5	0.6	0.7	0.6	0.8
Birth weight	0.5	1.0	1.6	0.7	1.2
Number of full sisters	0.5	0.7	0.9	1.0	0.6
Smoking status: Previous	0.5	0.7	1.3	-0.4	-1.1
Mineral and other dietary supplements	0.5	0.6	1.2	0.4	1.1
Basal cell carcinoma (self-reported)	0.5	0.6	1.0	-1.0	-0.4
Hypothyroidism (self reported)	0.4	1.0	1.7	1.3	0.5
Medication: Metformin	0.4	0.5	0.9	1.0	0.3
High blood pressure	0.4	1.0	1.8	0.4	-1.4
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	0.9	-0.0	1.0
Allergy	0.4	1.0	1.2	-1.1	-0.9
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	0.6	0.7	0.8
Medication: Blood pressure	0.4	0.7	1.3	0.1	-1.2
Pulse rate, automated reading	0.4	1.4	1.7	1.3	1.1
Age at last live birth	0.4	0.6	1.0	-0.5	-1.0
Family relationship satisfaction	0.4	0.5	0.7	0.8	0.6
Number of self-reported non-cancer illnesses	0.4	0.8	1.5	1.2	-0.0
Commuting to job workplace: Public transport	0.4	0.5	0.8	0.4	0.9
Alzheimer’s Disease (in father)	0.3	0.3	0.3	-0.6	-0.5
Ulcerative Colitis (UC)	0.3	0.6	1.0	-0.4	1.0
Body Mass Index (BMI) (2010)	0.3	0.4	0.9	0.9	0.0
HDL Cholesterol	0.3	0.5	0.9	0.0	1.0
Rheumatoid Arthritis	0.3	0.4	0.6	-0.8	0.5
Triglycerides	0.3	0.5	0.9	0.4	0.9
Type 2 Diabetes (T2D) (2012)	0.3	0.4	0.5	-0.7	-0.5
Cardiovascular Disease	0.3	1.0	1.9	-0.1	-1.4
Hair Pigment	0.3	9.7	10.6	-3.0	-3.3
Tanning	0.3	3.3	3.6	1.7	1.9
Maternal smoking around birth	0.3	0.5	0.9	0.2	0.9
Waist circumference	0.3	1.0	2.0	-0.1	-1.4
Hair/balding pattern: Pattern 2	0.3	0.4	0.5	-0.6	-0.7
Fluid intelligence score	0.3	0.7	1.3	0.4	1.1
Pulse rate	0.3	0.4	0.5	0.6	0.7
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	0.7	-0.8	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.8	0.9	0.0
Migraine (self-reported)	0.3	0.4	0.9	-0.1	-0.9
Overall health rating	0.3	0.6	0.9	0.9	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.7	0.3	0.8
Ever taken oral contraceptive pill	0.3	0.3	0.6	0.8	0.2
Medication: Blood pressure	0.3	0.5	1.0	-0.1	-1.0
Number of operations (self-reported)	0.3	0.5	0.6	0.6	0.8
Pain experienced in last month	0.3	0.5	0.7	-0.5	-0.8
Neuroticism (Nagel 2018)	0.2	0.4	0.8	0.0	0.9
Worry (Nagel 2018)	0.2	0.4	0.5	-0.7	-0.5
Qualifications: CSEs or equivalent	0.2	0.3	0.5	-0.4	-0.7
Supplements: Glucosamine	0.2	0.3	0.4	0.7	0.5
Nervous feelings	0.2	0.3	0.5	0.3	0.7
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.2	0.4	-0.2	0.7
Had other major operations	0.2	0.3	0.5	0.3	0.7
Mouth/teeth dental problems	0.2	0.4	0.7	0.8	-0.1
Trunk fat-free mass	0.2	1.1	1.6	1.3	0.8
Worrier / anxious feelings	0.2	0.3	0.4	-0.4	0.6
Lung cancer (father)	0.2	0.3	0.4	-0.4	-0.6
Trunk predicted mass	0.2	1.0	1.6	1.3	0.7
Blood clot in the leg (DVT)	0.2	0.3	0.3	0.5	0.6
Comparative body size at age 10	0.2	0.5	0.5	0.7	0.7
Age at first live birth	0.2	0.4	0.7	0.1	-0.8
Eye problems/disorders: None of the above	0.2	0.3	0.5	0.2	0.7
Alcohol intake frequency.	0.2	0.4	0.6	-0.4	-0.8
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.4	-0.2	-0.6
Supplements: Vitamin C	0.2	0.3	0.5	0.7	-0.2
Illnesses of siblings: Diabetes	0.2	0.3	0.5	0.3	0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	0.9	0.2	-1.0
Mood swings	0.2	0.3	0.7	-0.0	0.8
Long-standing illness, disability or infirmity	0.2	0.3	0.5	0.7	0.4
Illnesses of father: None of the above (group 1)	0.2	0.2	0.4	-0.6	0.1
Financial situation satisfaction	0.2	0.2	0.3	0.4	0.5
Irritability	0.2	0.3	0.4	-0.6	0.4
Risk taking	0.2	0.3	0.4	-0.6	-0.4
Ever depressed for a whole week	0.2	0.3	0.4	0.4	0.6
Vascular/heart problems diagnosed by doctor	0.2	0.5	0.6	-0.8	0.6
Major Depression (MDD)	0.1	0.2	0.3	-0.2	0.6
BMI	0.1	0.3	0.5	-0.3	-0.7
Waist Hip Ratio (WHR)	0.1	0.4	0.6	0.5	0.8
Lung FEV1/FVC ratio	0.1	0.5	0.8	0.4	0.9
Sensitivity / hurt feelings	0.1	0.1	0.1	-0.4	-0.3
Supplements: Zinc	0.1	0.1	0.1	0.2	0.4
Pack years adult smoking proportion	0.1	0.1	0.1	-0.4	-0.2
Leg fat-free mass (left)	0.1	0.3	0.5	0.7	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.2	-0.5	-0.2
Stomach or abdominal pain in last month	0.1	0.1	0.1	-0.3	0.3
Body mass index (BMI)	0.1	0.3	0.6	-0.0	-0.8
Pain all over the body in last month	0.1	0.1	0.1	0.2	0.3
Time employed in main current job	0.1	0.1	0.1	-0.2	-0.3
Falls in the last year	0.1	0.2	0.3	0.3	0.6
Mouth/teeth dental problems: Dentures	0.1	0.3	0.3	-0.5	-0.5
Length of working week for main job	0.1	0.1	0.3	-0.5	0.1
Ever highly irritable/argumentative for 2 days	0.1	0.2	0.2	0.3	0.5
Medication: Paracetamol	0.1	0.1	0.2	-0.5	-0.2
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.3	-0.5	0.1
Chronic bronchitis/emphysema (mother)	0.1	0.2	0.2	-0.4	0.4
Arm fat-free mass (right)	0.1	0.3	0.6	0.7	0.1
Number of children fathered	0.1	0.1	0.1	0.3	0.1
Mouth/teeth dental problems: Loose teeth	0.1	0.2	0.2	0.4	0.4
Whole body fat-free mass	0.1	0.5	0.9	0.9	0.4
Average weekly red wine intake	0.1	0.2	0.2	-0.3	0.5
Loneliness, isolation	0.1	0.2	0.3	-0.2	0.6
Commuting to job workplace: Walk	0.1	0.1	0.1	0.3	0.3
Medication for cholesterol	0.1	0.2	0.2	0.4	0.5
Back pain experienced in last month	0.1	0.2	0.3	0.2	0.6
Asthma (self-reported)	0.1	0.2	0.3	-0.3	-0.5
Whole body water mass	0.1	0.6	1.1	1.0	0.4
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.1	0.3	0.3
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.3	0.5	0.2
Medication: Paracetamol	0.1	0.1	0.2	-0.4	-0.3
Medication: Lisinopril	0.1	0.2	0.4	0.6	-0.0
Arm fat-free mass (left)	0.1	0.3	0.6	0.2	-0.8
Unable to work because of sickness or disability	0.1	0.1	0.3	-0.5	0.2
Pack years of smoking	0.1	0.1	0.2	-0.5	-0.2
Arm predicted mass (left)	0.1	0.3	0.5	0.3	-0.7
Depression (Nagel 2018)	0.0	0.1	0.1	-0.3	0.1
Breast Cancer	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	0.0	0.0	0.0	0.2	-0.2
Prostate Cancer	0.0	0.0	0.0	0.0	0.0
Mean Putamen Volume	0.0	0.0	0.0	-0.1	0.0
Fasting Glucose	0.0	0.0	0.0	0.2	0.0
Frequency of depressed mood in last 2 weeks	0.0	0.1	0.1	0.2	0.3
Age when periods started (menarche)	0.0	0.1	0.2	0.4	0.2
Medication: Levothyroxine sodium	0.0	0.0	0.0	0.1	0.1
Leg predicted mass (left)	0.0	0.2	0.4	0.7	0.1
Past tobacco smoking	0.0	0.1	0.1	-0.4	-0.0
Number of live births	0.0	0.1	0.1	0.2	0.3
Noisy workplace	0.0	0.1	0.1	-0.0	0.3
Asthma	0.0	0.0	0.0	0.0	-0.2
Tense / ‘highly strung’	0.0	0.0	0.1	0.0	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.1	0.1	0.3	0.2
Wheeze or whistling in the chest in last year	0.0	0.0	0.0	-0.2	0.1
Medication: Seretide 50 evohaler	0.0	0.0	0.1	-0.2	0.2
Arm predicted mass (right)	0.0	0.2	0.3	0.5	-0.3
Knee pain experienced in last month	0.0	0.0	0.0	0.1	-0.0
Leg fat-free mass (right)	0.0	0.3	0.5	0.7	0.3
Ever had bowel cancer screening	0.0	0.0	0.1	-0.2	0.2
Friendships satisfaction	0.0	0.0	0.1	-0.3	-0.1
Breast cancer (self-reported)	0.0	0.0	0.0	0.1	-0.0
Leg predicted mass (right)	0.0	0.2	0.4	0.6	0.2
Tinnitus: Yes, now most or all of the time	0.0	0.0	0.0	-0.1	-0.1
Ever smoked	0.0	0.1	0.1	0.2	0.4
Basal metabolic rate	0.0	0.2	0.2	0.4	-0.4
Age started oral contraceptive pill	0.0	0.0	0.0	-0.2	0.0
Commuting to job workplace: Cycle	0.0	0.0	0.1	-0.3	0.2
Myopia	0.0	0.0	0.0	-0.0	-0.1

Hub : Genes

LARP4

Models

Trait associations