Hub : Genes

AHNAK2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.2670	0.0960	1.2e-03	0.026	NA	0.043	NA	0.044	5.9e-02	NA	2.0e-02	NA	1.9e-02
2	GTEx	Esophagus Mucosa	0.1090	0.0330	1.6e-05	0.040	NA	0.059	NA	0.074	1.1e-03	NA	8.1e-05	NA	1.2e-05
3	GTEx	Esophagus Muscularis	0.1310	0.0420	1.1e-04	0.065	NA	0.066	NA	0.086	8.9e-05	NA	8.0e-05	NA	6.7e-06
4	GTEx	Nerve Tibial	0.1493	0.0542	4.5e-03	0.071	NA	0.026	NA	0.049	9.3e-06	NA	5.4e-03	NA	2.3e-04
5	GTEx	Skin Sun Exposed Lower leg	0.0710	0.0270	1.1e-03	0.024	NA	0.022	NA	0.015	3.9e-03	NA	5.4e-03	NA	1.8e-02
6	TCGA	Breast Invasive Carcinoma	0.0209	0.0108	5.3e-05	0.017	0.020	0.021	NA	0.021	1.7e-04	4.9e-05	2.5e-05	NA	2.9e-05
7	TCGA	Prostate Adenocarcinoma	0.0510	0.0260	1.0e-05	0.045	0.045	0.047	NA	0.044	1.8e-05	1.7e-05	1.1e-05	NA	2.1e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	2.5	3.9	7.5	2.1	1.9	2.1	-0.1	2.0	-1.9	2.7
Bipolar Disorder or Schizophrenia	0.4	1.0	2.3	1.1	0.8	1.3	-0.4	0.1	-0.9	1.5
Depressed Affect (Nagel 2018)	2.2	4.5	10.3	2.0	2.3	2.1	0.4	3.2	-1.4	2.3
Depression (Nagel 2018)	5.3	7.9	13.9	2.0	3.5	3.2	1.4	3.7	-1.5	3.3
Intelligence (Savage-Jansen 2018)	0.3	1.1	4.0	0.0	-0.0	-0.3	-1.7	2.0	0.6	0.5
Neuroticism (Nagel 2018)	0.7	1.7	3.6	1.7	1.1	1.1	-0.3	1.9	-1.2	1.4
Schizophrenia (2018)	0.2	0.3	1.8	-0.2	-0.4	-0.0	-0.4	-1.4	0.4	-0.3
Schizophrenia vs Biploar Disorder	1.1	1.5	6.7	0.0	0.0	0.0	0.0	0.0	1.9	-2.6
Worry (Nagel 2018)	0.2	0.4	1.4	1.2	-0.1	0.1	-0.6	0.6	-0.8	0.1
Alzheimer’s Disease (in mother)	2.6	3.0	5.5	1.6	2.0	1.6	-2.0	0.7	-1.4	2.3
Alzheimer’s Disease (in father)	0.4	0.4	0.9	0.7	0.5	0.2	0.2	0.9	-0.8	0.6
Alzheimer’s Disease (including proxy)	3.3	4.8	7.8	2.1	2.8	2.1	-1.1	2.4	-1.8	2.6
Crohns Disease (2017)	0.8	1.8	5.2	0.2	2.3	1.4	0.5	1.8	0.2	1.4
Irritable Bowel Disease (IBD)	3.2	7.6	17.8	1.8	4.2	3.1	1.3	3.3	-1.3	2.9
Ulcerative Colitis (UC)	3.4	6.4	13.0	1.8	3.6	2.8	1.4	3.0	-1.5	2.6
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	1.4	2.7	5.7	1.3	1.5	2.1	1.1	1.5	-1.2	2.4
Verbal and Numeric Reasoning (VNR)	0.5	1.2	6.9	0.7	0.4	0.3	-0.4	2.6	0.0	1.0
Breast Cancer	0.3	0.6	1.5	-0.0	-0.6	-0.8	-1.2	1.2	-0.4	-0.6
Ovarian Cancer	0.3	0.3	1.5	-0.2	0.4	0.0	0.7	-1.2	-0.4	0.1
Prostate Cancer	1.5	2.0	4.6	-2.1	-0.8	-1.6	-0.2	-0.3	1.6	-1.9
Age at First Birth	0.7	1.0	6.5	0.1	-0.5	-0.4	-2.6	-0.2	0.1	-0.4
Bipolar Disorder (2011)	0.3	0.3	1.9	0.0	0.0	0.0	0.0	0.0	-0.4	1.4
Body Mass Index (BMI) (2010)	1.2	1.7	6.8	-1.7	-0.8	-0.5	1.1	0.3	2.6	-0.3
Coronary Artery Disease (CAD)	0.1	0.1	0.7	0.0	0.0	0.0	0.0	0.0	0.3	-0.8
Crohns Disease (2012)	0.3	0.5	1.6	-0.2	1.3	0.6	-0.9	0.4	0.7	0.4
Mean Putamen Volume	2.4	2.7	3.8	1.9	1.6	1.7	-1.6	1.7	-1.0	1.9
Fasting Glucose	0.4	0.4	0.8	-0.1	0.7	0.5	-0.2	0.9	-0.8	0.9
HbA1C	0.2	0.2	0.6	-0.1	0.8	0.5	-0.7	0.0	-0.3	-0.1
HDL Cholesterol	1.2	1.9	3.3	-1.1	-1.7	-1.3	-1.8	-0.9	1.6	-1.0
LDL Cholesterol	0.1	0.2	0.4	-0.1	-0.5	-0.3	0.4	0.6	0.5	-0.0
Lupus	1.9	2.9	5.8	-2.0	-1.5	-1.5	-1.0	-2.4	1.3	-2.0
Neuroticism (2016)	2.1	3.0	6.8	1.3	1.7	1.9	-0.7	2.6	-0.6	2.2
Primary Biliary Cirrhosis	3.4	4.8	7.5	-2.7	-1.7	-2.2	1.3	-2.6	2.0	-2.5
Rheumatoid Arthritis	0.1	0.2	0.8	-0.4	0.1	-0.3	-0.1	-0.9	0.0	-0.3
Schizophrenia (2014)	0.4	0.9	2.0	-1.0	-0.9	-0.8	-0.1	-1.4	0.9	-1.1
Triglycerides	1.0	1.6	2.6	1.2	1.1	1.6	-1.2	-0.2	-1.5	1.6
Type 2 Diabetes (T2D) (2012)	0.2	0.2	1.2	0.0	0.0	0.0	0.0	0.0	0.6	-1.1
Ulcerative Colitis	3.2	4.6	9.3	1.6	3.0	2.2	0.1	2.9	-0.9	2.5
Blood Eosinophil Count	0.5	3.6	10.5	1.8	1.7	1.8	-0.5	3.2	-1.6	1.6
Blood Platelet Count	2.7	31.4	59.8	7.2	5.2	5.1	-0.9	5.4	-7.7	5.0
Blood Red Count	0.5	4.7	19.9	1.1	1.6	1.9	4.5	0.8	-1.7	1.4
Blood White Count	1.3	9.3	26.6	3.8	2.0	1.9	0.6	5.2	-3.4	2.2
Heel T-Score	0.0	0.4	1.0	0.4	0.3	0.1	1.0	0.9	-0.7	0.2
BMI	0.2	1.0	6.0	0.1	0.3	-0.8	0.5	2.4	0.2	-0.5
Height	0.0	0.9	1.7	0.7	-1.1	-0.1	-1.3	-0.2	-1.0	1.3
Waist Hip Ratio (WHR)	0.3	1.2	2.4	1.5	1.3	0.1	-0.6	1.6	-1.3	0.1
Systolic Blood Pressure	0.2	0.9	2.1	1.2	0.7	1.2	0.4	1.0	-1.5	0.3
Smoking Status	1.0	2.4	6.2	-1.3	-1.0	-0.9	2.0	-2.5	0.7	-1.5
Allergy or Eczema	0.9	2.4	8.0	-1.0	-1.7	-1.2	-1.6	-2.8	0.3	-0.9
Cardiovascular Disease	0.2	0.7	1.6	0.5	-0.6	-0.4	-1.3	-0.7	-1.1	-0.8
Hypothyroidism (self reported)	1.9	4.3	6.2	-2.4	-2.1	-2.2	-1.6	-1.7	1.6	-2.5
Respiratory disease	1.5	3.4	9.3	-1.8	-1.4	-1.3	1.4	-3.0	1.3	-2.0
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.7	-0.2	0.6	-0.3	-0.8	0.2	-0.1	-0.2
Lung FEV1/FVC ratio	0.1	0.3	1.4	0.5	-0.2	-0.3	0.7	1.2	-0.3	-0.3
Lung FVC	0.1	0.6	3.7	-0.3	-0.3	0.5	0.1	-1.9	0.0	0.5
Neuroticism	0.2	0.5	1.3	0.7	0.5	0.6	-0.8	1.1	-0.6	0.5
Chronotype (morning person)	0.7	1.5	2.3	-1.4	-1.5	-1.2	-1.1	-0.5	1.5	-1.2
Hair Pigment	0.0	0.6	2.6	-1.0	0.0	0.1	-0.4	-1.6	0.8	-0.1
Tanning	1.3	16.0	25.6	-3.9	-5.1	-4.7	-1.2	-2.6	4.3	-4.8
Hand grip strength (left)	0.1	0.4	1.7	-0.6	0.1	0.6	0.3	-1.3	0.2	-0.3
Number of treatments/medications taken	0.2	0.3	0.7	0.2	-0.8	-0.7	-0.2	-0.6	-0.3	-0.9
Average weekly spirits intake	0.4	0.5	1.3	0.9	0.4	0.5	1.1	0.1	-0.9	0.5
Sensitivity / hurt feelings	0.4	0.7	1.8	-1.4	-0.6	-0.2	-0.2	-1.1	1.1	-0.5
Frequency of depressed mood in last 2 weeks	3.3	4.7	9.8	1.4	2.3	2.7	1.6	2.0	-1.3	3.1
Hearing difficulty/problems: Yes	1.8	2.8	7.7	-1.7	-2.3	-1.4	0.0	-2.8	1.2	-0.8
Relative age of first facial hair	0.1	0.2	0.3	0.5	-0.5	0.1	0.3	-0.4	-0.5	0.4
Other serious medical condition/disability diagnosed by doctor	0.6	0.7	3.4	-0.2	-0.4	-0.8	-1.8	0.3	0.5	-0.7
Ever used hormone-replacement therapy (HRT)	0.5	0.7	3.8	-0.1	0.5	0.2	1.9	0.5	0.2	0.6
Ever had hysterectomy (womb removed)	0.8	0.8	2.1	-0.7	0.2	-0.9	1.4	0.5	1.3	-0.7
Systolic blood pressure, automated reading	0.4	1.1	1.9	1.3	0.8	1.1	0.2	1.4	-1.3	0.3
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.9	-0.3	0.3	0.3	0.9	0.7	0.6	0.2
Angina	1.1	1.4	2.0	-1.3	-1.4	-1.1	0.6	-0.8	1.4	-1.4
Medication for hormone replacement therapy	0.3	0.3	1.0	-0.3	-0.5	-1.0	0.2	-0.3	0.6	-0.8
Vitamin and mineral supplements	0.4	0.5	1.4	-1.2	-0.4	-0.3	-0.7	0.3	1.2	0.1
Supplements: Zinc	0.1	0.2	0.4	0.6	0.2	0.5	0.3	0.1	-0.6	0.2
Medication: Co-codamol	0.7	0.8	3.3	0.7	-0.4	-0.9	-1.8	0.0	-0.6	-0.7
Medication: Metformin	0.2	0.3	0.7	0.5	0.2	-0.1	-0.7	-0.6	-0.8	0.2
Diabetes (father)	0.2	0.2	0.8	0.4	0.3	-0.3	0.0	0.0	-0.5	-0.9
Diabetes (mother)	1.7	2.2	6.1	2.0	1.3	0.8	1.1	1.0	-2.5	0.7
Severe depression (siblings)	0.3	0.3	2.0	0.1	0.4	-0.0	1.4	0.3	-0.1	0.1
Pack years adult smoking proportion	1.8	2.7	5.7	1.9	1.7	1.5	0.1	2.4	-1.8	1.2
Impedance of leg (right)	0.4	2.0	9.4	-0.4	-0.7	-0.2	-1.9	-3.1	0.2	-0.5
Leg fat-free mass (left)	0.1	0.8	4.9	0.0	-0.2	-0.6	0.3	2.2	0.1	0.0
Trunk fat percentage	0.3	1.4	3.4	0.9	-0.9	-1.5	-1.9	1.4	-0.4	-0.6
Hand grip strength (right)	0.4	1.1	2.5	0.0	1.2	1.6	1.3	-0.8	-0.4	1.1
Townsend deprivation index at recruitment	1.3	1.8	4.3	-1.2	-0.9	-0.8	-2.1	-1.7	1.4	-0.9
Current tobacco smoking	1.4	2.3	5.4	1.4	0.8	1.4	2.3	-0.0	-2.2	1.1
Average weekly fortified wine intake	0.6	0.7	1.1	0.9	1.1	0.7	-0.5	0.8	-0.9	0.9
Maternal smoking around birth	0.5	0.7	1.4	-1.2	-0.9	-0.7	-0.2	-1.1	0.9	-0.6
Fed-up feelings	2.2	3.9	7.5	1.6	2.1	1.9	1.9	2.7	-1.0	2.1
Frequency of unenthusiasm / disinterest in last 2 weeks	3.9	5.1	8.3	2.1	2.9	2.2	1.2	2.7	-2.0	2.4
Relative age voice broke	0.2	0.3	0.6	0.6	-0.1	0.7	0.4	-0.2	-0.8	0.5
Taking other prescription medications	0.5	0.8	3.1	0.0	-0.6	-1.2	-1.8	-0.4	-0.2	-0.5
Age when periods started (menarche)	0.1	0.3	0.8	-0.1	-0.4	-0.4	-0.8	-0.7	-0.2	-0.9
Bilateral oophorectomy (both ovaries removed)	2.2	2.6	4.4	-2.1	-1.0	-2.1	0.8	-0.7	2.1	-1.7
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.3	1.1	0.2	-1.0	-0.6	-0.6	-0.4	-0.0	-0.7
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.9	-0.1	-0.4	-0.2	0.6	-0.9	-0.4	0.2
Qualifications: CSEs or equivalent	0.0	0.1	0.2	0.1	0.1	-0.2	-0.4	0.3	-0.2	-0.2
Serious illness, injury or assault to yourself	0.1	0.1	0.3	-0.1	-0.3	-0.5	0.0	-0.0	0.1	-0.4
High blood pressure	0.3	0.8	2.2	1.0	-0.3	-0.0	-1.5	-0.3	-1.3	-0.5
Hayfever, allergic rhinitis or eczema	0.4	0.8	2.7	0.1	-0.1	0.4	-1.4	-1.6	-0.5	0.5
Multivitamins +/- minerals	0.6	0.7	1.5	1.1	0.8	0.8	1.2	0.2	-1.0	0.4
Stomach or abdominal pain in last month	4.0	5.0	8.8	2.3	3.0	2.3	1.4	1.1	-2.8	2.0
Supplements: Glucosamine	0.1	0.2	1.1	0.4	-0.2	-0.1	1.0	0.1	-0.1	0.3
Diverticular disease/diverticulitis (self-reported)	1.8	2.2	3.4	-1.6	-1.5	-1.9	0.0	-1.5	1.4	-1.6
Medication: Atenolol	0.8	1.0	3.2	-0.9	-0.8	-0.8	1.8	0.3	1.0	-0.7
Medication: Levothyroxine sodium	0.7	1.3	1.9	-1.0	-1.0	-1.1	-1.4	-1.3	0.4	-1.4
Sitting height	0.1	0.7	1.7	0.6	0.1	0.4	1.3	1.3	-0.3	0.9
Chronic bronchitis/emphysema (father)	2.6	3.1	4.8	-2.1	-1.8	-2.0	0.2	-1.1	2.2	-2.0
High blood pressure (mother)	0.5	0.7	2.0	-0.4	-1.0	-1.4	-0.7	-0.5	-0.1	-0.9
Body mass index (BMI)	0.3	1.2	5.1	0.3	-0.7	-1.4	0.2	2.3	0.3	-0.8
Impedance of leg (left)	0.3	1.7	7.6	0.4	-0.1	0.5	-1.8	-2.8	-0.4	0.1
Leg predicted mass (left)	0.2	0.8	5.2	0.0	-0.1	-0.6	0.3	2.3	0.2	0.1
Trunk fat mass	0.3	1.4	4.0	0.9	-0.9	-1.4	-1.4	2.0	-0.3	-0.4
Waist circumference	0.5	1.9	10.8	0.8	-0.0	-1.2	-0.5	3.3	-0.2	-0.4
Number of incorrect matches in round	0.9	1.5	5.0	-1.3	-1.4	-0.8	0.2	-2.2	1.0	-0.7
Past tobacco smoking	3.0	5.4	9.1	2.5	2.1	1.8	-1.7	3.0	-2.3	2.6
Alcohol usually taken with meals	0.5	0.8	1.8	0.3	1.2	0.9	1.1	-0.0	-0.6	1.3
Nervous feelings	0.8	1.5	3.0	1.5	1.0	1.7	0.5	0.6	-1.6	1.1
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.6	-0.2	0.4	0.2	-0.1	0.8	0.2	0.7
Hearing difficulty/problems with background noise	0.5	0.7	2.2	0.3	-1.0	-0.4	-1.5	-1.2	-0.5	-0.1
Hair/balding pattern: Pattern 2	1.7	2.2	4.5	1.3	2.1	2.0	-0.1	1.4	-0.6	1.8
Had menopause	0.4	0.5	1.0	0.8	0.7	0.2	0.3	1.0	-0.8	0.6
Had other major operations	0.5	0.6	1.1	0.8	0.4	1.1	0.4	0.7	-0.7	1.0
Forced vital capacity (FVC)	0.3	1.0	2.8	0.8	0.8	1.4	-0.2	-0.3	-0.8	1.7
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.9	0.3	-1.4	-0.9	-0.1	-0.7	-0.4	-1.0
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	3.9	-0.8	0.5	0.0	0.8	2.0	0.7	0.3
Qualifications: None of the above	0.1	0.1	0.5	0.4	-0.1	-0.1	0.7	0.3	-0.1	-0.3
Financial difficulties in last 2 years	0.1	0.2	0.7	-0.3	0.1	0.3	0.4	-0.8	0.4	0.4
Mouth/teeth dental problems	0.1	0.2	1.0	0.1	-0.2	-0.1	0.3	1.0	0.2	-0.6
Heart attack	0.4	0.5	1.4	-0.6	-0.3	-0.5	1.2	0.8	1.1	0.1
Allergy	0.2	0.4	2.6	0.4	0.0	-0.3	0.5	1.6	0.3	0.1
Pain all over the body in last month	0.8	0.9	2.3	0.8	1.2	0.5	1.5	1.0	-0.6	0.1
Diabetes (self-reported)	0.1	0.2	0.8	-0.4	0.1	-0.3	-0.9	-0.4	0.4	-0.4
Hayfever/allergic rhinitis (self-reported)	2.0	2.6	4.5	1.7	1.3	2.1	1.5	-0.4	-2.1	1.5
Medication: Ramipril	0.2	0.3	0.6	0.6	-0.5	-0.8	-0.7	0.2	-0.5	-0.4
Medication: Simvastatin	1.7	2.5	4.3	-1.6	-2.0	-1.8	0.0	-0.8	1.6	-2.1
Fluid intelligence score	0.2	0.3	1.3	0.2	-0.4	-0.3	-0.8	1.1	-0.3	0.1
Illnesses of siblings	1.5	2.1	6.8	-0.7	-1.2	-1.7	-2.6	-0.1	0.7	-1.6
Neuroticism score	0.3	0.7	1.3	0.8	0.8	1.1	0.2	0.7	-0.8	1.2
Weight	0.2	1.2	6.8	0.8	-0.4	-0.8	0.0	2.6	-0.2	-0.1
Impedance of arm (right)	0.6	2.6	11.2	1.0	0.9	1.1	-3.3	-1.1	-1.1	1.2
Arm fat percentage (right)	0.4	1.8	4.8	0.7	-0.8	-1.6	-1.8	2.2	0.0	-0.6
Trunk fat-free mass	0.1	0.7	2.5	-0.5	-0.7	-0.7	1.0	1.6	0.3	-0.2
Hip circumference	0.4	1.7	8.4	1.2	-0.2	-0.7	-1.0	2.9	-0.6	0.3
Time employed in main current job	0.7	0.8	2.3	-0.7	-0.8	-1.3	0.5	-1.5	0.3	-0.6
Alcohol intake versus 10 years previously	0.3	0.4	1.9	0.2	0.4	-0.2	0.6	1.4	0.0	0.2
Father’s age at death	0.3	0.4	1.2	0.2	0.6	0.2	1.1	0.9	0.2	0.7
Worrier / anxious feelings	0.1	0.1	0.6	0.1	-0.0	0.1	0.8	-0.6	-0.1	0.2
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	2.5	1.5	1.2	1.0	-1.2	1.1	-1.5	1.6
Falls in the last year	1.0	1.3	4.3	1.8	0.5	1.0	0.5	0.2	-2.1	0.6
Hair/balding pattern: Pattern 3	1.3	1.9	3.4	-1.3	-1.7	-1.8	-1.6	-1.2	0.5	-1.1
Number of live births	0.6	0.8	4.3	0.4	0.4	0.8	2.1	-0.1	-0.4	0.5
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	2.7	0.8	0.9	1.3	-0.1	0.5	-0.6	1.6
Pulse rate	0.4	0.7	1.5	-0.1	0.1	-1.2	0.9	1.1	0.1	-1.2
Happiness	0.2	0.3	1.0	0.3	0.2	0.6	0.5	-0.1	-0.4	1.0
Noisy workplace	0.3	0.4	1.5	0.7	0.3	0.6	0.6	0.3	-1.2	0.2
Qualifications: A levels/AS levels or equivalent	0.3	0.7	4.0	0.7	0.1	-0.2	-2.0	0.3	-0.4	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	3.3	1.0	0.7	0.6	0.7	0.0	-1.8	1.1
Mouth/teeth dental problems: Dentures	1.2	2.1	6.0	-1.4	-1.6	-1.2	0.5	-2.4	0.7	-1.5
Asthma	0.8	1.5	6.1	-0.9	-0.4	-0.1	1.5	-2.5	0.3	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.0	0.0	0.1	0.1	0.1	0.3	-0.0	-0.3	0.2	-0.3
Medication: Cholesterol lowering	1.6	2.4	6.5	-2.0	-1.5	-1.4	-0.1	0.5	2.5	-1.4
Depression (self-reported)	1.6	2.0	4.5	1.3	1.5	2.0	0.2	0.9	-0.9	2.1
Medication: Lansoprazole	2.0	2.3	4.8	2.2	1.0	1.6	-0.2	1.1	-1.8	1.8
Prospective memory result	1.3	1.6	4.3	1.7	0.9	1.5	0.6	-0.1	-2.1	0.8
Lung cancer (father)	1.3	1.5	8.0	0.2	0.7	0.6	2.8	1.3	0.1	-0.2
Illnesses of mother	0.4	0.5	2.1	-0.6	-0.4	-0.1	1.4	-0.7	0.5	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.6	0.5	0.9	1.1	0.1	0.8	-0.3	1.3
Pulse wave Arterial Stiffness index	0.4	0.5	3.0	0.0	0.2	0.1	1.7	0.3	0.1	-0.5
Impedance of arm (left)	0.4	1.8	10.2	0.4	0.4	0.4	-3.2	-1.2	-0.5	0.6
Arm fat mass (right)	0.3	1.4	6.8	0.9	-0.4	-1.2	-0.8	2.6	-0.2	-0.2
Trunk predicted mass	0.1	0.7	2.1	-0.6	-0.8	-0.8	1.0	1.5	0.4	-0.3
Standing height	0.1	0.7	1.9	0.6	0.3	0.8	-0.7	0.9	-0.8	1.4
Length of working week for main job	0.3	0.4	1.2	-0.2	-0.1	-0.5	-1.1	-0.6	-0.5	-0.7
Exposure to tobacco smoke at home	0.3	0.3	1.5	0.4	0.2	0.2	-0.3	0.3	-1.2	-0.0
Breastfed as a baby	2.9	3.5	6.2	1.8	1.8	2.5	1.1	1.0	-1.9	2.5
Tense / ‘highly strung’	0.7	1.2	2.3	-1.3	-1.1	-0.4	0.2	-1.5	1.4	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.5	-0.5	-0.0	-0.4	-0.2	0.7	0.6	0.5
Hair/balding pattern: Pattern 4	4.1	10.0	12.5	-2.9	-3.5	-3.3	-3.0	-3.5	2.8	-3.2
Birth weight of first child	2.1	3.8	7.4	-1.5	-2.7	-2.1	-1.8	-2.0	1.7	-1.7
Peak expiratory flow (PEF)	0.5	1.1	2.1	0.1	0.8	1.0	1.4	1.4	0.5	1.4
Pulse wave reflection index	0.1	0.2	0.4	0.1	-0.7	0.1	0.4	-0.7	-0.1	0.0
Ever highly irritable/argumentative for 2 days	1.3	1.5	7.6	0.4	0.8	1.4	-0.2	2.8	0.0	0.7
Loud music exposure frequency	1.5	1.6	2.3	-1.3	-1.5	-1.4	-1.5	-0.8	1.3	-0.8
Qualifications: O levels/GCSEs or equivalent	2.1	3.4	7.5	2.0	1.5	1.6	-0.0	2.7	-1.5	2.2
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	2.7	1.1	0.7	0.4	-1.6	0.6	-0.4	1.2
Blood clot in the leg (DVT)	1.3	1.7	10.5	0.4	0.8	0.4	-0.6	3.2	0.2	0.5
Medication: Paracetamol	1.8	2.9	4.5	1.6	2.0	2.0	1.4	0.7	-1.7	2.1
Headache pain in last month	0.7	1.3	2.9	1.2	1.4	0.4	-0.7	1.7	-0.7	1.2
Medication for cholesterol, blood pressure or diabetes	1.1	1.7	3.2	1.3	1.8	1.4	1.1	-0.6	-1.5	1.2
Glaucoma (self-reported)	0.3	0.3	0.8	-0.8	-0.3	-0.4	0.2	0.7	0.9	-0.2
Gout (self-reported)	0.4	0.5	2.1	0.3	0.5	0.3	-0.8	1.4	0.0	0.5
Hypothyroidism/myxoedema (self-reported)	1.7	3.2	4.9	-1.9	-1.7	-2.0	-2.2	-1.2	1.4	-2.0
Medication: Amlodipine	1.0	1.3	2.4	-1.3	-1.5	-1.5	0.5	-1.2	0.9	-0.8
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.9	-0.5	0.2	-0.2	0.6	-0.9	0.3	-1.0
Birth weight	0.9	1.9	4.1	-2.0	-1.3	-1.2	0.7	-1.3	1.5	-1.2
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.6	-0.2	0.8	0.2	-0.6	0.3	0.7	-0.7
High blood pressure (siblings)	2.6	3.7	7.8	1.7	2.0	2.6	0.6	1.1	-1.6	2.8
Forced vital capacity (FVC), Best measure	0.6	2.3	5.1	1.3	1.7	2.1	-0.2	0.7	-1.2	2.3
Body fat percentage	0.3	1.4	2.5	0.9	-0.9	-1.5	-1.6	1.5	-0.3	-0.7
Leg fat percentage (right)	0.3	1.1	2.7	0.5	-0.9	-1.6	-0.5	1.3	0.1	-1.3
Arm fat-free mass (right)	0.1	0.7	2.1	-0.2	-0.7	-0.9	1.4	1.3	0.1	-0.5
Exposure to tobacco smoke outside home	0.3	0.4	1.2	0.2	-0.2	-0.5	0.4	0.7	-0.6	-1.1
Comparative body size at age 10	0.1	0.4	1.5	0.3	0.4	0.0	-0.8	1.2	-0.1	-0.3
Number of full brothers	0.8	1.0	2.1	-1.0	-1.0	-0.4	-0.8	-1.4	1.3	-0.4
Worry too long after embarrassment	0.4	0.6	2.1	-0.7	-0.9	-0.6	0.1	-1.4	0.2	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.8	0.5	0.4	0.4	0.1	1.3	-0.4	0.1
Wheeze or whistling in the chest in last year	0.4	0.6	1.5	0.6	0.5	0.6	0.8	-1.2	-1.0	-0.2
Number of children fathered	0.5	0.6	3.8	-0.3	0.5	0.1	1.9	0.1	-0.2	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.1	0.7	1.1	0.8	-0.4	1.0	-0.6	0.7
Age at first live birth	1.6	2.8	5.3	2.1	2.0	2.3	-0.2	0.4	-2.1	1.4
Pulse wave peak to peak time	0.5	0.5	3.2	0.0	-0.0	0.1	-1.8	-0.2	-0.1	0.7
Health satisfaction	1.1	1.4	3.6	1.1	1.0	1.2	0.5	1.9	-0.9	1.1
Shortness of breath walking on level ground	0.9	1.0	2.6	0.5	1.1	1.3	1.6	0.8	-0.5	1.0
Qualifications: College or University degree	0.7	2.4	4.9	0.9	2.2	2.2	-0.5	1.0	-0.7	2.1
Eye problems/disorders: None of the above	0.4	0.4	1.0	1.0	0.1	-0.3	0.7	0.7	-0.7	0.7
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.9	-0.3	-0.6	-1.0	0.6	0.2	0.3	-0.8
Emphysema/chronic bronchitis	1.5	1.6	3.0	1.5	1.3	1.7	0.6	0.3	-1.7	1.1
Medication for pain relief, constipation, heartburn	0.9	1.6	2.6	-1.5	-1.1	-1.5	-0.7	-1.0	1.6	-1.1
Neck or shoulder pain in last month	1.2	1.7	3.8	1.9	1.5	1.1	-0.5	0.5	-1.4	1.6
Medication: Blood pressure	0.7	1.2	2.6	-1.0	-1.6	-1.5	-0.7	0.5	0.9	-0.9
Angina (self-reported)	1.2	1.6	2.4	-1.4	-1.4	-1.1	0.7	-0.9	1.5	-1.5
Migraine (self-reported)	0.2	0.3	0.6	0.0	0.6	0.5	0.8	-0.5	-0.6	0.4
Medication: Ibuprofen	0.2	0.2	0.5	-0.4	-0.3	-0.1	-0.1	-0.3	0.7	-0.6
Medication: Allopurinol	0.4	0.5	2.0	0.4	-0.1	-0.4	-1.4	1.0	-0.1	-0.0
Medication: Omeprazole	1.2	1.4	3.9	2.0	-0.2	0.2	-1.4	1.3	-1.6	0.3
Medication: Seretide 50 evohaler	0.3	0.4	0.9	0.2	0.7	0.5	0.2	1.0	0.5	0.8
Mean time to correctly identify matches	1.6	3.0	4.0	1.7	1.3	2.0	1.7	1.9	-1.4	2.0
Heart disease (mother)	0.3	0.4	0.7	-0.9	-0.4	-0.6	-0.8	0.2	0.9	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	1.1	0.5	-0.2	0.2	-0.1	-0.2	-0.4	1.0
Whole body fat mass	0.3	1.3	4.0	1.0	-0.8	-1.4	-1.1	2.0	-0.4	-0.4
Leg fat mass (right)	0.3	1.1	2.6	0.4	-1.0	-1.6	-0.4	1.6	0.2	-1.0
Arm predicted mass (right)	0.1	0.7	2.2	-0.3	-0.7	-0.8	1.5	1.3	0.1	-0.3
Pulse rate, automated reading	0.3	1.1	3.8	-0.3	-0.3	-1.3	1.1	0.3	0.6	-1.9
Alcohol intake frequency.	0.3	0.6	3.3	0.5	0.3	-0.0	-0.4	1.8	-0.4	0.4
Comparative height size at age 10	0.0	0.2	0.7	0.0	0.1	-0.5	0.1	0.8	0.6	0.1
Number of full sisters	0.2	0.3	1.2	0.5	0.1	0.0	-0.2	-1.1	-0.6	-0.3
Suffer from ‘nerves’	0.8	1.3	3.1	1.8	0.5	1.2	-0.3	0.7	-1.6	1.0
Overall health rating	0.1	0.3	1.0	-0.3	-0.4	-1.0	0.7	0.6	0.3	-0.2
Chest pain or discomfort	0.6	0.8	3.2	0.2	1.8	1.2	0.7	0.6	-0.2	0.5
Had major operations	0.8	0.9	2.2	-0.9	-1.5	-1.0	0.5	-0.7	0.8	-0.9
Age at last live birth	2.5	3.7	6.8	2.3	1.9	2.6	-0.2	0.3	-2.6	1.7
Family relationship satisfaction	0.8	1.0	2.1	0.8	1.1	0.9	-0.5	0.9	-0.9	1.4
Leg pain on walking	0.5	0.7	1.7	1.1	0.3	1.0	-0.1	0.2	-0.9	1.3
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	0.7	-0.4	-0.4	-0.2	-0.8	-0.7	0.6	-0.4
Commuting to job workplace: Car/motor vehicle	1.5	1.7	3.3	1.1	1.0	1.1	1.8	1.7	-1.0	1.0
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	2.1	0.9	0.7	0.8	-1.4	0.4	-0.6	0.2
Medication: Aspirin	0.8	1.0	4.9	0.5	0.3	0.7	2.2	1.1	-0.1	0.3
Supplements: Vitamin C	0.9	1.1	4.0	0.7	0.6	1.2	2.0	0.7	-0.4	0.7
Knee pain experienced in last month	0.0	0.0	0.1	0.3	0.1	0.2	0.1	-0.4	0.2	0.1
Hypertension (Self-reported)	0.3	0.7	2.5	0.8	-0.5	-0.2	-1.6	-0.3	-1.1	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	3.2	1.1	0.2	0.3	-1.4	1.8	-0.7	0.4
Illnesses of father: Heart disease	0.3	0.4	1.0	-1.0	-0.2	-0.8	0.6	-0.2	0.5	-0.7
Illnesses of siblings: Diabetes	0.7	0.9	2.1	0.7	1.4	0.9	1.4	0.6	-0.6	0.6
Smoking status: Previous	4.2	6.3	9.6	-2.8	-2.5	-2.3	0.4	-3.1	2.6	-2.9
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	1.9	0.9	1.2	0.9	-1.1	1.3	-1.0	1.4
Whole body fat-free mass	0.1	0.7	3.0	-0.3	-0.6	-0.7	0.8	1.7	0.2	-0.1
Leg fat-free mass (right)	0.2	1.0	6.1	0.4	0.2	-0.1	0.4	2.5	-0.2	0.6
Arm fat percentage (left)	0.4	1.7	5.2	0.8	-0.7	-1.6	-1.5	2.3	-0.1	-0.7
Average weekly red wine intake	0.3	0.5	1.1	-0.2	1.0	1.1	0.8	-0.3	0.3	0.6
Handedness (chirality/laterality): Left-handed	0.5	0.6	3.6	-0.4	-0.3	-0.3	-1.9	0.3	0.1	-0.4
Mood swings	1.2	2.1	3.4	1.2	1.7	1.7	0.7	1.4	-1.3	1.9
Loneliness, isolation	3.2	4.5	7.7	2.8	2.1	1.8	1.2	2.3	-2.1	2.1
Long-standing illness, disability or infirmity	0.1	0.2	1.1	0.3	0.1	-0.4	0.2	1.1	-0.0	-0.1
Ever had bowel cancer screening	0.2	0.3	0.7	-0.5	-0.5	-0.3	0.6	-0.3	0.8	-0.4
Diabetes diagnosed by doctor	0.1	0.1	0.3	0.2	0.6	0.0	-0.5	0.3	-0.2	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.3	0.7	0.1	-0.2	-0.4	-0.4	-0.8	-0.3	-0.8
Friendships satisfaction	0.4	0.5	1.1	0.5	0.6	0.6	-0.8	0.6	-0.5	1.1
Qualifications: nursing, teaching	0.4	0.6	1.6	-0.9	0.0	-0.3	-0.6	1.0	1.2	-0.1
Commuting to job workplace: Walk	0.8	0.8	1.3	1.0	0.9	1.0	0.8	-0.2	-1.1	1.0
Eye problems/disorders: Cataract	0.8	0.9	4.3	-1.0	-0.5	-0.2	-0.1	-2.1	0.5	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	2.0	-1.3	-0.1	-0.5	0.3	-0.4	1.4	0.2
Medication for cholesterol	0.3	0.5	1.0	0.3	0.7	0.9	-0.6	0.9	-0.4	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	6.6	-0.3	-0.0	0.4	0.9	-2.6	-0.3	-0.4
Back pain experienced in last month	0.4	0.6	2.9	0.0	-1.1	-0.4	-0.1	-1.7	0.1	-0.3
Mineral and other dietary supplements	0.3	0.4	1.2	-0.9	0.1	0.3	-1.1	0.6	0.8	0.1
Breast cancer (self-reported)	0.6	0.7	2.0	-0.9	0.2	-0.9	-1.4	0.3	0.7	-0.7
Asthma (self-reported)	1.0	2.1	8.7	-1.0	-0.9	-0.5	1.3	-2.9	0.4	-1.4
Osteoporosis (self-reported)	0.1	0.1	0.4	0.1	-0.3	-0.7	-0.2	-0.3	-0.1	-0.5
Osteoarthritis (self-reported)	0.9	1.2	6.3	0.6	0.2	0.6	2.5	-0.9	-0.4	0.4
Medication: Aspirin	0.5	0.6	3.5	0.1	0.2	0.5	1.9	0.6	-0.2	-0.1
Medication: Gliclazide	0.6	0.6	2.4	1.1	0.3	0.1	0.7	-0.5	-1.6	0.3
Illnesses of father: None of the above (group 1)	1.1	1.4	2.5	1.6	0.3	1.2	-1.2	0.4	-1.5	1.4
Smoking status: Current	0.8	1.3	4.1	0.9	0.2	0.9	2.0	-0.5	-1.6	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.5	0.4	0.3	0.1	0.7	0.5	-0.4	0.2
Whole body water mass	0.1	0.7	3.3	-0.3	-0.6	-0.7	0.8	1.8	0.2	-0.1
Leg predicted mass (right)	0.2	0.9	5.7	0.4	0.1	-0.2	0.3	2.4	-0.3	0.5
Arm fat mass (left)	0.3	1.4	5.1	0.6	-0.7	-1.6	-0.9	2.3	0.0	-0.6
Number of self-reported non-cancer illnesses	0.2	0.3	0.6	-0.2	-0.8	-0.7	0.3	-0.7	0.1	-0.6
Average weekly champagne plus white wine intake	0.3	0.4	1.3	0.4	-0.0	0.5	-0.4	-0.7	-1.1	0.4
Miserableness	1.7	2.9	5.4	1.3	1.9	1.8	-0.3	2.3	-1.0	2.3
Guilty feelings	0.1	0.2	0.6	-0.4	0.2	0.3	0.7	-0.5	0.1	0.3
Wears glasses or contact lenses	1.3	1.5	2.6	-1.1	-1.6	-1.4	1.1	-0.6	1.4	-1.1
Ever taken oral contraceptive pill	0.2	0.2	0.5	0.0	-0.3	-0.7	0.5	-0.1	0.2	-0.7
Hearing aid user	0.9	1.0	1.5	-1.0	-1.2	-1.1	0.8	-0.9	0.9	-0.9
Mother’s age at death	0.4	0.5	1.3	-0.1	1.1	1.1	0.5	0.5	0.1	0.9
Financial situation satisfaction	0.7	0.9	3.0	0.1	0.8	1.3	0.8	0.5	0.0	1.7
Tinnitus: Yes, now most or all of the time	1.3	1.6	4.8	-2.1	-0.1	-0.5	1.1	-0.3	2.2	-0.3
Commuting to job workplace: Public transport	0.4	0.4	2.1	-0.2	0.4	0.4	-0.4	-1.5	-0.5	0.5
Eye problems/disorders: Glaucoma	0.3	0.3	1.6	0.4	0.6	0.4	-0.1	1.3	-0.1	0.2
Medication: Blood pressure	0.5	1.0	4.7	0.1	-0.9	-0.4	0.5	-2.2	-0.6	-0.9
Pain type(s) experienced in last month: Hip pain	0.8	1.0	2.2	-0.3	-1.5	-1.3	-0.8	-1.1	0.5	-0.8
Supplements: Fish oil (including cod liver oil)	1.0	1.3	3.5	1.4	0.9	0.7	1.9	0.8	-1.2	0.4
High cholesterol (Self-reported)	1.2	2.2	4.4	-1.0	-2.0	-1.7	-0.4	-1.7	0.5	-2.1
Medication: Bendroflumethiazide	0.2	0.3	2.2	-0.1	-0.2	-0.0	1.5	0.1	0.2	-0.2
Medication: Paracetamol	1.5	2.3	3.0	1.5	1.6	1.7	1.4	0.7	-1.6	1.7
Medication: Lisinopril	1.1	1.4	2.8	-0.9	-1.2	-1.4	0.0	-1.7	0.6	-1.5
Medication: Atorvastatin	2.0	2.4	4.1	-1.4	-2.0	-2.0	-0.0	-1.6	1.2	-1.7
Illnesses of father: High blood pressure	0.2	0.2	0.5	-0.7	0.1	-0.6	0.6	0.0	0.5	-0.4
Alcohol drinker status: Never	0.9	1.1	2.0	1.3	0.9	1.0	-0.7	0.7	-1.4	0.9
Ever smoked	1.1	1.9	6.7	-0.8	-0.9	-0.2	2.6	-2.1	0.4	-0.9
Basal metabolic rate	0.1	0.7	3.6	-0.0	-0.5	-0.7	0.5	1.9	0.1	-0.1
Leg fat percentage (left)	0.2	0.8	2.2	1.1	-0.5	-1.1	-0.3	1.5	-0.4	-0.8
Arm fat-free mass (left)	0.1	0.6	2.7	0.0	-0.4	-0.5	1.2	1.7	-0.1	-0.1
Number of operations (self-reported)	0.8	1.2	2.2	-1.5	-1.2	-1.1	0.1	-0.5	1.2	-1.4
Average weekly beer plus cider intake	2.5	3.7	6.1	-1.4	-1.8	-2.0	-1.5	-2.5	1.4	-2.4
Irritability	0.4	0.7	1.5	0.8	0.6	0.6	0.9	1.2	-1.1	0.5
Risk taking	0.1	0.1	0.5	-0.3	0.4	-0.2	-0.1	-0.2	-0.0	-0.7
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.5	-0.5	0.4	0.7	0.2	-0.6	0.4	0.0
Fractured/broken bones in last 5 years	0.4	0.5	1.2	-0.6	-0.9	-0.6	-0.0	-1.1	0.4	-0.5
Age started oral contraceptive pill	0.3	0.3	1.8	0.1	0.0	0.2	-1.3	-0.7	-0.4	0.1
Diastolic blood pressure, automated reading	0.1	0.4	1.4	0.5	0.0	-0.0	0.6	1.2	0.1	-0.9
Ever depressed for a whole week	1.2	1.5	3.4	-1.4	-0.5	-0.8	1.8	0.9	1.8	-0.6
Unable to work because of sickness or disability	0.1	0.2	0.5	-0.2	-0.1	-0.1	0.7	-0.3	0.6	-0.4
Commuting to job workplace: Cycle	2.2	2.7	5.2	-1.6	-1.6	-1.2	-2.3	-2.0	1.0	-1.2
Myopia	0.1	0.1	0.4	0.4	0.5	-0.2	0.6	0.2	-0.4	-0.0
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.9	-0.7	0.2	0.0	1.0	0.0	0.8	0.5
Cholesterol lowering medication	1.0	1.5	4.5	-0.5	-1.1	-1.2	0.5	-2.1	-0.1	-1.7
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	3.0	1.7	-0.1	0.1	-1.4	0.7	-1.7	0.3
Pain experienced in last month	0.2	0.3	0.9	-0.9	-0.3	-0.5	-0.2	-0.4	0.4	-0.7
Supplements: Calcium	0.1	0.1	0.3	0.1	-0.4	-0.1	-0.4	0.6	0.3	0.6
Basal cell carcinoma (self-reported)	0.5	0.6	2.3	1.1	0.3	0.0	0.1	0.5	-1.5	0.3
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.0	-0.7	-0.4	-0.5	0.9	0.5	1.0	0.1
Deep venous thrombosis (DVT) (self-reported)	0.9	1.1	7.0	0.2	0.5	0.2	-0.6	2.6	0.3	0.3
Heart disease (siblings)	2.5	3.1	5.8	-2.4	-1.4	-1.1	1.6	-2.3	1.8	-1.3
Alcohol drinker status: Previous	1.4	1.6	2.7	-1.2	-1.4	-1.4	-0.4	-1.3	1.2	-1.6
Pack years of smoking	1.3	1.9	5.0	1.6	1.3	1.2	0.2	2.2	-1.4	0.9
Impedance of whole body	0.4	1.8	7.2	0.3	0.3	0.6	-2.7	-2.2	-0.4	0.4
Leg fat mass (left)	0.2	0.9	3.6	0.9	-0.5	-1.2	-0.4	1.9	-0.2	-0.5
Arm predicted mass (left)	0.1	0.5	1.5	-0.1	-0.6	-0.7	0.9	1.2	0.0	-0.3