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chr2:22,911,727-25,735,072

Best TWAS P=4.6e-29 · Best GWAS P=7.83e-33 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
41	GTEx	Testis	AC009228.1	0.27	0.34	lasso	5	0.38	5.4e-18	11.93	11.2	4.6e-29	0.95	0.01	0.99	TRUE
43	GTEx	Thyroid	ITSN2	0.10	0.06	enet	21	0.06	3.1e-05	7.25	8.8	1.1e-18	0.80	0.39	0.60	TRUE
1	CommonMind	Brain Pre-frontal Cortex	CENPO	0.07	0.03	bslmm	322	0.03	7.0e-05	5.14	-6.0	2.7e-09	-0.18	0.62	0.02	TRUE
74	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	PFN4	0.08	0.03	blup	43	0.03	6.0e-03	9.64	5.9	3.8e-09	0.44	0.00	0.59	TRUE
4	GTEx	Adipose Subcutaneous	UBXN2A	0.06	0.04	lasso	5	0.04	5.2e-04	6.60	5.6	2.5e-08	0.28	0.85	0.08	TRUE
82	The Cancer Genome Atlas	Testicular Germ Cell Tumors	LOC375190	0.12	0.04	blup	82	0.06	2.7e-03	8.33	-5.5	4.2e-08	-0.35	0.05	0.15	TRUE
18	GTEx	Cells EBV-transformed lymphocytes	PFN4	0.18	0.13	lasso	12	0.12	8.9e-05	9.62	10.5	7.0e-26	0.64	0.22	0.38	FALSE
29	GTEx	Heart Atrial Appendage	UBXN2A	0.08	0.02	lasso	3	0.02	5.2e-02	10.27	10.5	9.7e-26	0.53	0.22	0.32	FALSE
67	The Cancer Genome Atlas	Brain Lower Grade Glioma	UBXN2A	0.04	0.04	lasso	1	0.03	1.4e-04	10.25	-10.2	1.2e-24	-0.52	0.03	0.92	FALSE
57	The Cancer Genome Atlas	Esophageal Carcinoma	C2orf84	0.13	0.04	lasso	3	0.06	4.8e-03	7.46	10.2	1.3e-24	0.86	0.02	0.92	FALSE
58	The Cancer Genome Atlas	Glioblastoma Multiforme	C2orf84	0.13	0.07	blup	56	0.05	1.5e-02	8.36	10.2	1.3e-24	0.73	0.02	0.36	FALSE
31	GTEx	Heart Left Ventricle	PFN4	0.23	0.28	lasso	6	0.28	4.1e-15	9.61	10.2	2.6e-24	0.67	1.00	0.00	FALSE
26	GTEx	Esophagus Mucosa	PFN4	0.16	0.15	lasso	4	0.15	3.6e-10	9.62	10.2	2.7e-24	0.68	0.98	0.02	FALSE
20	GTEx	Colon Transverse	SF3B14	0.09	0.05	lasso	9	0.02	4.9e-02	8.66	10.1	3.6e-24	0.75	0.17	0.70	FALSE
28	GTEx	Esophagus Muscularis	AC009228.1	0.11	0.06	enet	16	0.12	9.9e-08	7.08	10.0	2.1e-23	0.80	0.13	0.87	FALSE
14	GTEx	Brain Putamen basal ganglia	PFN4	0.32	0.17	lasso	5	0.12	1.1e-03	9.64	9.8	1.1e-22	0.66	0.02	0.68	FALSE
46	METSIM	Adipose	UBXN2A	0.07	0.03	bslmm	403	0.06	5.3e-10	6.61	9.8	1.1e-22	0.65	0.85	0.15	FALSE
80	The Cancer Genome Atlas	Rectum Adenocarcinoma	PFN4	0.38	0.11	lasso	5	0.05	2.8e-02	9.62	9.8	1.3e-22	0.67	0.00	0.82	FALSE
2	CommonMind	Brain Pre-frontal Cortex	UBXN2A	0.22	0.18	enet	28	0.24	3.0e-28	8.19	-9.8	1.9e-22	-0.55	0.83	0.17	FALSE
22	GTEx	Colon Transverse	PFN4	0.14	0.07	lasso	2	0.04	3.3e-03	9.61	9.7	5.1e-22	0.67	0.11	0.08	FALSE
49	ROSMAP	Brain Pre-frontal Cortex	PFN4	0.05	0.03	lasso	1	0.03	1.7e-04	9.64	9.6	5.3e-22	0.67	0.41	0.02	FALSE
70	The Cancer Genome Atlas	Lung Adenocarcinoma	PFN4	0.15	0.09	lasso	3	0.09	7.3e-11	9.64	9.6	5.3e-22	0.67	0.00	1.00	FALSE
63	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PFN4	0.10	0.07	lasso	2	0.06	1.1e-07	9.62	9.6	6.3e-22	0.67	0.00	1.00	FALSE
55	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	PFN4	0.19	0.16	lasso	2	0.15	5.5e-08	9.62	9.6	6.8e-22	0.67	0.00	1.00	FALSE
76	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	PFN4	0.20	0.18	lasso	1	0.16	4.3e-07	9.61	9.6	7.1e-22	0.67	0.00	1.00	FALSE
61	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PFN4	0.13	0.07	lasso	4	0.06	4.4e-07	9.62	9.1	1.0e-19	0.64	0.00	1.00	FALSE
23	GTEx	Esophagus Gastroesophageal Junction	SF3B14	0.10	0.01	lasso	8	0.00	3.5e-01	9.00	9.0	1.7e-19	0.67	0.06	0.49	FALSE
52	ROSMAP	Brain Pre-frontal Cortex	RP11-507M3.1	0.11	0.12	enet	17	0.14	6.4e-17	8.78	9.0	2.6e-19	0.80	1.00	0.00	FALSE
78	The Cancer Genome Atlas	Prostate Adenocarcinoma	PFN4	0.12	0.08	lasso	6	0.07	6.3e-08	9.62	9.0	3.0e-19	0.64	0.00	1.00	FALSE
34	GTEx	Muscle Skeletal	PFN4	0.12	0.09	lasso	4	0.09	5.6e-09	9.62	8.9	6.0e-19	0.63	0.98	0.02	FALSE
71	The Cancer Genome Atlas	Lung Adenocarcinoma	UBXN2A	0.05	0.00	blup	46	0.01	1.3e-02	-2.30	8.9	6.4e-19	0.42	0.01	0.44	FALSE
15	GTEx	Breast Mammary Tissue	PFN4	0.08	0.04	enet	16	0.05	1.0e-03	9.62	8.7	5.0e-18	0.77	0.03	0.71	FALSE
69	The Cancer Genome Atlas	Lung Adenocarcinoma	C2orf84	0.10	0.14	lasso	8	0.15	6.2e-17	8.78	8.7	5.3e-18	0.69	1.00	0.00	FALSE
45	METSIM	Adipose	PFN4	0.04	0.01	blup	306	0.03	1.9e-05	9.64	8.6	5.7e-18	0.64	0.35	0.44	FALSE
44	GTEx	Thyroid	AC009228.1	0.10	0.10	lasso	5	0.11	1.1e-08	8.83	8.4	4.5e-17	0.75	0.69	0.31	FALSE
48	ROSMAP	Brain Pre-frontal Cortex	UBXN2A	0.03	0.01	lasso	4	0.02	2.2e-03	10.36	-8.3	8.9e-17	-0.44	0.30	0.18	FALSE
32	GTEx	Lung	KLHL29	0.08	0.00	lasso	6	0.00	3.4e-01	9.62	8.2	2.6e-16	0.57	0.14	0.42	FALSE
7	GTEx	Adipose Visceral Omentum	AC009228.1	0.14	0.18	lasso	5	0.18	2.0e-09	7.46	8.2	3.6e-16	0.67	0.92	0.08	FALSE
8	GTEx	Adrenal Gland	PFN4	0.20	0.15	lasso	2	0.18	3.9e-07	9.64	8.1	4.0e-16	0.59	0.19	0.17	FALSE
84	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	PFN4	0.27	0.02	blup	43	0.08	3.1e-03	9.62	8.1	5.6e-16	0.55	0.00	0.86	FALSE
73	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PFN4	0.10	0.07	enet	5	0.08	5.5e-09	9.64	8.1	7.8e-16	0.59	0.00	1.00	FALSE
5	GTEx	Adipose Visceral Omentum	UBXN2A	0.10	0.08	enet	29	0.03	9.8e-03	7.22	8.1	8.6e-16	0.34	0.63	0.20	FALSE
33	GTEx	Lung	PFN4	0.14	0.12	enet	8	0.15	7.6e-12	9.62	8.0	1.6e-15	0.61	1.00	0.00	FALSE
53	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PFN4	0.11	0.00	enet	8	0.03	9.2e-04	9.62	7.9	2.2e-15	0.58	0.00	1.00	FALSE
36	GTEx	Pituitary	PFN4	0.34	0.03	lasso	14	0.02	1.1e-01	9.64	7.9	3.8e-15	0.56	0.04	0.10	FALSE
6	GTEx	Adipose Visceral Omentum	PFN4	0.08	0.02	enet	14	0.04	3.1e-03	9.62	7.6	2.1e-14	0.62	0.07	0.36	FALSE
72	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C2orf84	0.12	0.15	enet	19	0.15	2.1e-16	8.66	7.6	2.2e-14	0.66	1.00	0.00	FALSE
35	GTEx	Nerve Tibial	PFN4	0.25	0.16	lasso	5	0.20	3.8e-14	9.62	7.5	4.7e-14	0.57	1.00	0.00	FALSE
66	The Cancer Genome Atlas	Brain Lower Grade Glioma	PFN4	0.09	0.07	blup	43	0.08	5.3e-09	9.64	7.4	1.3e-13	0.60	0.00	1.00	FALSE
24	GTEx	Esophagus Gastroesophageal Junction	PFN4	0.13	0.01	lasso	12	0.01	9.7e-02	11.50	7.4	1.5e-13	0.41	0.10	0.15	FALSE
50	ROSMAP	Brain Pre-frontal Cortex	FAM228A	0.07	0.03	blup	285	0.06	3.0e-08	0.91	7.3	1.9e-13	0.47	1.00	0.00	FALSE
40	GTEx	Testis	FAM228B	0.14	0.09	enet	11	0.10	3.3e-05	-6.75	-7.3	2.0e-13	-0.40	0.60	0.09	FALSE
81	The Cancer Genome Atlas	Stomach Adenocarcinoma	C2orf84	0.14	0.14	blup	55	0.15	7.7e-11	8.66	7.2	4.9e-13	0.58	0.99	0.01	FALSE
37	GTEx	Small Intestine Terminal Ileum	UBXN2A	0.18	0.08	enet	33	0.16	2.5e-04	7.32	7.0	3.0e-12	0.37	0.21	0.26	FALSE
10	GTEx	Artery Tibial	PFN4	0.09	0.04	enet	15	0.09	9.1e-08	9.62	7.0	3.2e-12	0.52	0.13	0.33	FALSE
68	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	C2orf84	0.16	0.16	blup	55	0.13	1.2e-06	8.66	7.0	3.2e-12	0.65	0.91	0.09	FALSE
77	The Cancer Genome Atlas	Prostate Adenocarcinoma	C2orf84	0.22	0.21	lasso	10	0.24	1.4e-24	8.78	7.0	3.5e-12	0.60	1.00	0.00	FALSE
16	GTEx	Breast Mammary Tissue (Female)	PFN4	0.11	0.12	enet	16	0.09	1.0e-03	7.85	6.9	4.4e-12	0.76	0.03	0.46	FALSE
9	GTEx	Artery Aorta	AC009228.1	0.10	0.06	lasso	2	0.04	4.4e-03	7.19	6.8	7.7e-12	0.77	0.54	0.16	FALSE
75	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	C2orf84	0.34	0.22	enet	20	0.35	2.9e-15	7.46	6.8	1.0e-11	0.60	0.99	0.01	FALSE
83	The Cancer Genome Atlas	Thyroid Carcinoma	PFN4	0.21	0.10	blup	43	0.15	8.4e-15	9.62	6.7	1.6e-11	0.55	0.00	1.00	FALSE
65	The Cancer Genome Atlas	Brain Lower Grade Glioma	C2orf84	0.18	0.10	lasso	7	0.11	3.5e-12	7.46	6.6	4.0e-11	0.47	1.00	0.00	FALSE
12	GTEx	Brain Cerebellum	FKBP1B	0.25	0.01	enet	16	0.20	1.6e-06	9.62	6.5	6.9e-11	0.59	0.07	0.20	FALSE
64	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PFN4	0.14	0.02	blup	43	0.03	5.4e-03	9.64	6.4	1.4e-10	0.48	0.00	0.96	FALSE
25	GTEx	Esophagus Gastroesophageal Junction	AC009228.1	0.12	0.05	enet	14	0.03	3.7e-02	9.00	6.4	1.6e-10	0.57	0.15	0.43	FALSE
62	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C2orf84	0.43	0.18	lasso	9	0.20	2.4e-22	8.83	6.4	1.7e-10	0.53	1.00	0.00	FALSE
27	GTEx	Esophagus Muscularis	ITSN2	0.10	0.04	lasso	7	0.09	6.1e-06	-1.53	6.2	6.5e-10	0.33	0.21	0.33	FALSE
30	GTEx	Heart Atrial Appendage	PFN4	0.22	0.06	lasso	7	0.10	2.8e-05	0.41	6.2	7.8e-10	0.39	0.61	0.10	FALSE
59	The Cancer Genome Atlas	Glioblastoma Multiforme	PFN4	0.37	0.13	blup	43	0.16	1.4e-05	9.64	6.2	7.9e-10	0.52	0.00	0.94	FALSE
3	GTEx	Adipose Subcutaneous	TP53I3	0.11	0.03	enet	48	0.04	3.8e-04	8.83	-6.1	1.2e-09	-0.41	0.30	0.14	FALSE
13	GTEx	Brain Cerebellum	FAM228B	0.28	0.00	lasso	14	0.01	1.4e-01	0.71	-6.1	1.4e-09	-0.38	0.17	0.37	FALSE
39	GTEx	Stomach	FAM228B	0.14	0.05	lasso	2	0.04	3.4e-03	8.83	-6.0	1.7e-09	-0.45	0.35	0.19	FALSE
60	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C2orf84	0.16	0.13	enet	20	0.14	5.8e-16	8.83	6.0	2.1e-09	0.47	1.00	0.00	FALSE
42	GTEx	Thyroid	PFN4	0.17	0.05	lasso	8	0.14	6.1e-11	9.61	6.0	2.2e-09	0.46	0.93	0.02	FALSE
79	The Cancer Genome Atlas	Rectum Adenocarcinoma	MFSD2B	0.33	0.03	enet	10	0.04	4.3e-02	0.71	-5.9	3.9e-09	-0.23	0.02	0.11	FALSE
56	The Cancer Genome Atlas	Colon Adenocarcinoma	C2orf84	0.09	0.06	enet	9	0.09	8.0e-06	-5.83	5.7	1.2e-08	0.61	0.58	0.25	FALSE
38	GTEx	Spleen	UBXN2A	0.31	0.11	enet	19	0.17	4.1e-05	-5.36	5.7	1.4e-08	0.28	0.44	0.08	FALSE
21	GTEx	Colon Transverse	UBXN2A	0.11	0.01	enet	8	0.03	8.7e-03	6.59	5.6	2.1e-08	0.26	0.22	0.10	FALSE
51	ROSMAP	Brain Pre-frontal Cortex	FAM228B	0.23	0.01	enet	51	0.14	5.2e-18	9.62	5.6	2.8e-08	0.50	0.94	0.06	FALSE
11	GTEx	Artery Tibial	AC009228.1	0.09	0.01	enet	11	0.02	1.1e-02	8.83	5.5	3.7e-08	0.30	0.24	0.42	FALSE
54	The Cancer Genome Atlas	Breast Invasive Carcinoma	PFN4	0.15	0.08	blup	43	0.11	1.9e-22	9.61	5.5	4.8e-08	0.43	0.00	1.00	FALSE
17	GTEx	Breast Mammary Tissue (Female)	FAM228B	0.16	0.04	lasso	11	0.02	8.9e-02	0.95	-5.4	5.6e-08	-0.33	0.18	0.30	FALSE
19	GTEx	Cells Transformed fibroblasts	PFN4	0.15	0.05	enet	10	0.14	2.3e-10	9.62	5.3	1.5e-07	0.41	0.96	0.00	FALSE
47	ROSMAP	Brain Pre-frontal Cortex	KLHL29	0.08	0.03	enet	27	0.02	1.1e-03	1.12	5.2	2.1e-07	0.18	0.93	0.00	FALSE