TWAS hub - LPAR5

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Testis	0.4300	0.099	2.9e-05	0.197	NA	0.119	NA	0.178	3.9e-09	NA	6.1e-06	NA	2.4e-08
2	METSIM	Adipose	0.0623	0.023	4.4e-04	-0.001	0.017	-0.002	0.015	-0.002	6.4e-01	0.0011	7.5e-01	0.0023	9.3e-01
3	TCGA	Colon Adenocarcinoma	0.0510	0.033	9.4e-03	0.027	0.025	0.010	NA	0.017	9.8e-03	0.0130	8.4e-02	NA	3.3e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Serious illness, injury or assault to yourself	5.0	6.0	10.7	0.4	-3.3	2.7
Eye problems/disorders: Diabetes related eye disease	3.8	4.2	8.7	-0.4	-1.9	3.0
Neck or shoulder pain in last month	3.8	5.3	10.3	0.9	-2.2	3.2
Back pain experienced in last month	3.8	5.5	9.7	0.5	-3.1	2.6
Osteoporosis (self-reported)	3.8	4.7	5.8	1.8	2.2	-2.4
Ever had stillbirth, spontaneous miscarriage or termination	3.6	3.8	5.5	-2.2	1.0	-2.3
Chronic bronchitis/emphysema (father)	3.5	4.1	9.9	-0.3	-3.1	1.5
Diabetes (self-reported)	3.4	5.3	12.8	-1.0	-1.4	3.6
Mean time to correctly identify matches	3.3	6.3	11.6	1.7	2.1	-3.4
Reaction Time	3.2	6.2	14.2	1.0	1.8	-3.8
Angina (self-reported)	3.0	4.0	6.6	2.3	-0.4	2.6
Age at last live birth	2.9	4.2	6.8	-1.7	1.7	-2.6
Commuting to job workplace: Walk	2.9	3.2	8.6	0.7	0.6	2.9
Age when periods started (menarche)	2.8	6.6	12.7	-2.6	0.8	-3.6
Diabetes diagnosed by doctor	2.7	4.5	10.1	-0.8	-1.6	3.2
Angina	2.6	3.4	5.8	2.0	-0.4	2.4
Mouth/teeth dental problems: Dentures	2.6	4.3	8.0	1.7	-1.5	2.8
Heart disease (siblings)	2.6	3.2	8.5	-0.5	-2.9	0.9
Chest pain or discomfort	2.5	3.6	5.2	-0.7	-2.2	2.3
Breast cancer (self-reported)	2.5	3.0	3.6	1.4	-1.9	1.8
Heel T-Score	2.4	19.1	33.3	-0.4	-4.9	5.8
Type 2 Diabetes (T2D) (2018)	2.4	4.5	11.4	-0.5	-1.4	3.4
Qualifications: CSEs or equivalent	2.4	3.2	5.8	1.9	-0.1	2.4
Had other major operations	2.3	2.8	4.9	1.9	0.3	2.2
Qualifications: O levels/GCSEs or equivalent	2.3	3.6	9.7	0.6	0.8	3.1
Medication: Seretide 50 evohaler	2.3	2.6	5.7	-1.4	0.3	-2.4
Hearing difficulty/problems with background noise	2.2	3.5	7.3	2.7	1.5	0.9
Allergy	2.2	5.1	6.7	1.4	-2.6	2.6
Commuting to job workplace: Public transport	2.2	2.6	3.0	-1.6	1.5	-1.7
Allergy or Eczema	2.1	5.6	13.8	0.2	3.7	-1.7
Heel bone mineral density (BMD) T-score, automated (right)	2.1	4.7	8.0	1.0	-2.8	2.3
Medication: Simvastatin	2.1	3.1	4.7	1.6	-1.4	2.2
Eye problems/disorders: None of the above	2.1	2.4	6.3	-0.9	0.1	-2.5
Blood Platelet Count	2.0	23.3	60.4	1.4	7.8	2.7
Townsend deprivation index at recruitment	2.0	2.8	6.0	-1.5	2.4	-0.3
Number of children fathered	2.0	2.2	4.1	-1.6	-2.0	-0.2
Health satisfaction	2.0	2.6	7.0	-0.0	-1.0	2.6
Hearing difficulty/problems: Yes	1.9	2.9	4.7	2.2	1.7	1.1
Hayfever/allergic rhinitis (self-reported)	1.9	2.5	6.0	-0.6	1.0	-2.5
Pulse wave Arterial Stiffness index	1.9	2.2	3.5	1.8	0.1	1.9
Qualifications: None of the above	1.8	3.9	8.2	-1.6	-2.9	-0.9
Happiness	1.8	2.2	4.3	-1.5	-0.5	2.1
Long-standing illness, disability or infirmity	1.8	2.8	5.4	1.5	-1.0	2.3
Alzheimer’s Disease (in mother)	1.7	2.0	3.9	-2.0	0.5	-1.4
HbA1C	1.7	1.9	4.0	-2.0	-0.8	-1.1
Pain all over the body in last month	1.7	1.8	3.1	-1.1	1.1	-1.8
Pulse wave peak to peak time	1.7	2.0	3.1	-1.7	-0.4	-1.8
Mouth/teeth dental problems: Loose teeth	1.7	2.0	4.4	0.6	-1.1	2.1
Medication: Gliclazide	1.7	1.9	3.8	-1.2	0.5	1.9
Neuroticism (2016)	1.6	2.3	5.0	0.7	-2.2	1.1
Lung FVC	1.6	8.0	20.2	4.5	1.6	-1.1
Average weekly spirits intake	1.6	2.0	3.1	-1.0	-1.4	1.8
Supplements: Zinc	1.6	1.7	2.6	-1.3	0.9	1.6
High blood pressure (mother)	1.6	2.3	4.0	1.1	1.2	2.0
Forced vital capacity (FVC)	1.6	6.1	15.2	3.9	-1.0	1.5
Number of operations (self-reported)	1.6	2.3	4.6	1.4	-0.8	2.1
Deep venous thrombosis (DVT) (self-reported)	1.6	2.0	4.8	-0.9	0.8	-2.2
Alzheimer’s Disease (including proxy)	1.5	2.2	3.8	-1.9	1.0	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.4	5.8	1.0	-1.8	2.4
Average weekly red wine intake	1.5	2.2	5.7	-2.4	-0.4	-0.9
Stomach or abdominal pain in last month	1.4	1.8	4.9	0.7	0.1	2.2
Pulse wave reflection index	1.4	1.8	3.6	1.9	0.2	1.3
Myopia	1.4	2.0	3.5	1.5	1.9	-0.3
Cholesterol lowering medication	1.4	2.0	3.6	1.0	-1.2	1.9
Blood Red Count	1.3	12.9	26.5	3.3	-1.2	5.2
Cardiovascular Disease	1.3	4.4	7.1	-2.7	-0.6	2.4
Tinnitus: Yes, but not now, but have in the past	1.3	1.3	2.9	1.0	0.4	1.7
Hayfever, allergic rhinitis or eczema	1.3	2.9	5.3	-0.6	2.3	-1.7
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.6	4.4	0.4	0.4	2.1
Hypertension (Self-reported)	1.3	3.5	9.7	-0.8	0.3	3.1
Smoking status: Previous	1.3	1.9	4.6	2.1	-0.7	0.7
Eye problems/disorders: Cataract	1.3	1.5	2.8	0.7	-1.0	1.7
Mother’s age at death	1.3	1.7	3.9	0.3	2.0	-1.0
Financial situation satisfaction	1.3	1.7	4.6	0.2	-0.5	2.1
Medication: Bendroflumethiazide	1.3	1.9	2.7	0.9	-1.5	1.6
Fractured/broken bones in last 5 years	1.3	1.7	1.9	1.2	1.3	-1.4
Supplements: Calcium	1.3	1.4	3.1	1.8	1.1	0.1
HDL Cholesterol	1.2	2.0	5.2	-0.7	0.6	-2.3
Vitamin and mineral supplements	1.2	1.7	4.5	-2.1	-0.1	0.7
Medication: Metformin	1.2	1.6	4.7	-0.4	-0.1	2.2
Medication: Ramipril	1.2	1.5	3.9	-0.0	-0.8	2.0
Forced expiratory volume in 1-second (FEV1)	1.2	4.1	11.6	3.4	0.0	0.9
Medication: Ventolin 100micrograms inhaler	1.2	1.6	2.6	-1.4	-1.6	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.5	3.9	0.8	2.0	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.5	5.8	2.4	1.3	-0.4
Average weekly beer plus cider intake	1.2	1.7	3.4	-1.8	-0.7	-1.1
Irritability	1.2	2.1	3.6	-1.9	-0.1	-1.6
Pain experienced in last month	1.2	2.0	3.3	0.2	1.6	-1.8
Systolic Blood Pressure	1.1	5.3	10.6	0.0	-2.3	3.2
Medication for hormone replacement therapy	1.1	1.2	3.6	1.9	0.1	-0.3
High blood pressure	1.1	3.0	8.4	-0.7	0.4	2.9
Impedance of arm (right)	1.1	5.1	13.0	-0.9	1.2	-3.6
Alcohol intake versus 10 years previously	1.1	1.6	3.0	1.7	-0.2	1.3
Noisy workplace	1.1	1.4	2.7	0.9	1.6	0.7
Asthma	1.1	2.2	4.5	-1.2	0.8	-2.1
Exposure to tobacco smoke at home	1.1	1.3	3.4	-0.2	1.8	0.6
Blood clot in the leg (DVT)	1.1	1.4	2.6	-0.9	0.9	-1.6
Birth weight	1.1	2.3	5.9	-2.4	-0.3	-1.0
Asthma (self-reported)	1.1	2.1	4.5	-1.3	0.6	-2.1
Medication: Aspirin	1.1	1.4	3.0	0.8	-1.7	0.8
Ever taken oral contraceptive pill	1.1	1.2	2.0	-0.6	-1.4	1.2
Hearing aid user	1.1	1.3	2.4	1.0	-1.5	-0.7
Intelligence (Savage-Jansen 2018)	1.0	2.9	5.0	0.8	-1.8	2.2
Fasting Glucose	1.0	1.2	3.1	0.6	1.8	0.2
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	2.9	0.8	-0.6	1.7
Ever used hormone-replacement therapy (HRT)	1.0	1.2	3.3	1.8	0.6	0.0
Systolic blood pressure, automated reading	1.0	3.0	8.1	0.2	-0.9	2.8
Hand grip strength (right)	1.0	2.7	6.2	0.8	-2.5	1.1
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	3.0	0.7	1.7	0.3
Forced vital capacity (FVC), Best measure	1.0	3.6	10.3	3.2	-0.4	0.7
Arm fat-free mass (right)	1.0	5.1	9.9	1.4	-1.8	3.1
Wheeze or whistling in the chest in last year	1.0	1.8	3.6	-1.9	-1.0	-0.9
Age at first live birth	1.0	1.8	4.9	-0.6	-0.3	-2.2
Overall health rating	1.0	2.2	5.9	0.8	-0.2	2.4
Commuting to job workplace: Car/motor vehicle	1.0	1.1	3.1	0.2	-1.8	-0.5
Illnesses of father: Heart disease	1.0	1.4	2.2	1.1	0.9	1.5
Mood swings	1.0	1.7	3.4	-1.3	0.2	-1.9
Ever had bowel cancer screening	1.0	1.2	3.3	-0.5	0.2	1.8
Ever depressed for a whole week	1.0	1.2	1.5	-1.2	1.1	-1.0
Vascular/heart problems diagnosed by doctor	1.0	2.7	7.9	0.5	0.0	-2.8
Age at First Birth	0.9	1.4	2.9	-0.6	1.7	-0.9
Body Mass Index (BMI) (2010)	0.9	1.2	3.5	0.0	0.3	1.9
Triglycerides	0.9	1.4	3.4	0.9	0.3	1.8
Alcohol usually taken with meals	0.9	1.5	2.2	0.7	1.5	-1.3
Medication: Lansoprazole	0.9	1.0	1.8	1.3	-1.0	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.9	8.5	2.9	0.5	0.1
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	3.2	-1.8	0.5	0.4
Gout (self-reported)	0.9	1.2	2.5	-0.0	-1.6	1.0
Medication: Amlodipine	0.9	1.2	2.0	1.1	1.4	-0.5
Chronic bronchitis/emphysema (mother)	0.9	1.1	1.9	-0.0	1.4	-1.1
Medication: Ibuprofen	0.9	1.1	1.7	-1.3	-1.3	0.2
Arm predicted mass (right)	0.9	4.4	8.7	1.3	-1.7	3.0
Pulse rate, automated reading	0.9	2.9	7.0	1.1	-0.7	2.7
Alcohol intake frequency.	0.9	2.0	5.7	2.4	0.5	-0.1
Knee pain experienced in last month	0.9	1.5	4.1	0.2	0.5	2.0
Wears glasses or contact lenses	0.9	1.0	3.0	0.2	1.7	-0.3
Medication: Blood pressure	0.9	1.7	4.2	0.4	-0.9	2.0
Ever had prostate specific antigen (PSA) test	0.9	1.0	1.8	1.1	-0.3	1.4
Diastolic blood pressure, automated reading	0.9	2.9	5.8	1.6	-0.6	2.4
Heart attack/myocardial infarction (self-reported)	0.9	1.2	3.0	0.2	-1.7	0.7
LDL Cholesterol	0.8	1.3	3.7	-1.9	-0.3	-0.4
Medication: Co-codamol	0.8	1.0	1.8	-1.3	0.8	-0.6
Heart attack	0.8	1.1	2.7	0.2	-1.6	0.7
Impedance of arm (left)	0.8	3.5	9.5	-0.8	0.6	-3.1
Tense / ‘highly strung’	0.8	1.4	3.9	-2.0	0.0	-0.6
Comparative height size at age 10	0.8	4.6	6.8	1.0	-2.6	2.4
Smoking status: Current	0.8	1.2	3.6	-1.9	0.1	0.0
Average weekly champagne plus white wine intake	0.8	1.1	2.0	0.5	1.4	-0.9
Commuting to job workplace: Cycle	0.8	1.0	2.2	-0.7	-1.5	0.4
Impedance of whole body	0.8	4.2	8.7	-1.9	-0.1	-3.0
Bipolar Disorder (2018)	0.7	1.0	2.1	-1.0	1.4	0.0
Crohns Disease (2017)	0.7	1.6	4.0	0.1	-2.0	1.0
Number of treatments/medications taken	0.7	1.2	3.4	-0.0	-0.4	1.9
Relative age of first facial hair	0.7	1.3	2.0	-1.4	0.4	-1.4
Severe depression (siblings)	0.7	0.7	1.1	0.3	1.0	1.0
Current tobacco smoking	0.7	1.2	3.5	-1.9	0.2	-0.1
Fed-up feelings	0.7	1.3	2.1	0.3	-1.3	1.5
Medication: Levothyroxine sodium	0.7	1.2	2.9	-0.1	-0.8	1.7
Number of incorrect matches in round	0.7	1.1	3.2	0.0	0.3	-1.8
Trunk fat-free mass	0.7	4.0	8.1	1.4	-1.4	2.8
Trunk predicted mass	0.7	3.8	7.8	1.3	-1.4	2.8
Birth weight of first child	0.7	1.3	2.7	0.3	1.1	1.7
Loud music exposure frequency	0.7	0.7	1.4	-0.6	0.6	-1.2
High blood pressure (siblings)	0.7	1.0	2.4	0.9	0.1	1.5
Number of full brothers	0.7	0.9	1.2	0.5	-1.1	1.1
Heart disease (mother)	0.7	0.8	2.0	1.4	-0.4	0.6
Medication: Aspirin	0.7	0.9	1.6	0.7	-1.3	0.8
Qualifications: nursing, teaching	0.7	1.1	1.7	0.5	1.1	-1.3
Whole body water mass	0.7	3.9	7.7	1.5	-1.4	2.8
Supplements: Fish oil (including cod liver oil)	0.7	0.9	1.3	0.8	-0.9	1.2
High cholesterol (Self-reported)	0.7	1.2	2.4	-1.6	-1.1	0.3
Arm fat-free mass (left)	0.7	3.5	7.7	1.0	-1.4	2.8
Age started oral contraceptive pill	0.7	0.9	1.8	-0.2	1.3	-0.9
Major Depression (MDD)	0.6	0.7	1.0	1.0	-1.0	0.4
Chronotype (morning person)	0.6	1.3	1.9	1.4	-1.4	-0.1
Diabetes (mother)	0.6	0.8	1.2	0.1	-1.1	1.1
Medication: Atenolol	0.6	0.8	1.3	-1.0	-1.1	-0.3
Had menopause	0.6	0.8	1.4	1.0	1.2	-0.0
Time employed in main current job	0.6	0.7	1.5	-0.8	0.1	-1.2
Father’s age at death	0.6	0.8	2.1	1.5	0.5	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.9	-1.4	-0.3	-0.2
Prospective memory result	0.6	0.7	1.8	-1.4	0.4	0.3
Peak expiratory flow (PEF)	0.6	1.3	3.7	1.9	0.5	-0.2
Headache pain in last month	0.6	1.1	2.4	1.0	-1.5	-0.2
Comparative body size at age 10	0.6	1.6	3.0	-1.3	0.5	-1.7
Shortness of breath walking on level ground	0.6	0.7	1.3	0.5	-1.1	0.6
Migraine (self-reported)	0.6	0.7	1.1	0.3	1.0	-1.0
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	2.1	1.5	0.3	0.4
Whole body fat-free mass	0.6	3.4	6.5	1.4	-1.3	2.5
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.0	-1.0	-1.0	0.5
Basal metabolic rate	0.6	3.2	5.9	1.3	-1.4	2.4
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.2	0.5	1.1	0.8
Basal cell carcinoma (self-reported)	0.6	0.7	1.2	-0.9	0.0	1.1
Alcohol drinker status: Previous	0.6	0.6	1.4	0.0	0.7	-1.2
Arm predicted mass (left)	0.6	3.0	6.4	0.9	-1.4	2.5
Verbal and Numeric Reasoning (VNR)	0.5	1.1	1.6	1.3	-0.8	1.1
Crohns Disease (2012)	0.5	0.9	1.5	1.2	-1.1	0.0
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.5	-0.5	-1.2	0.0
Blood White Count	0.5	3.6	5.0	-2.2	-1.0	2.2
Waist Hip Ratio (WHR)	0.5	2.5	7.3	-0.1	2.7	-0.2
Hypothyroidism (self reported)	0.5	1.2	3.0	-0.4	-0.7	1.7
Hand grip strength (left)	0.5	1.3	3.2	-0.8	-1.8	0.1
Sensitivity / hurt feelings	0.5	0.8	1.8	0.1	0.7	-1.4
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.5	-0.5	-1.2	-0.7
Ever had hysterectomy (womb removed)	0.5	0.6	1.3	0.0	1.1	0.7
Pack years adult smoking proportion	0.5	0.7	1.4	-0.7	-0.6	1.2
Maternal smoking around birth	0.5	0.8	1.4	1.2	0.9	-0.2
Impedance of leg (left)	0.5	2.6	5.2	-2.3	-1.1	-1.2
Nervous feelings	0.5	1.0	2.3	-0.6	1.5	0.4
Fluid intelligence score	0.5	1.0	1.9	0.5	-1.0	1.4
Worrier / anxious feelings	0.5	0.9	1.4	-0.6	-1.2	0.9
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	1.9	-1.4	-0.5	0.7
Falls in the last year	0.5	0.6	1.6	0.5	-1.3	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	0.9	-1.0	-0.9	0.0
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	1.4	1.2	0.2	-1.0
Worry too long after embarrassment	0.5	0.8	1.6	-0.5	-1.3	0.8
Medication: Omeprazole	0.5	0.6	1.3	0.2	0.6	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	0.8	-0.9	0.8	-0.6
Supplements: Vitamin C	0.5	0.6	1.1	0.8	0.1	1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	2.9	1.7	-0.1	0.5
Medication for cholesterol	0.5	0.8	1.3	-0.4	1.2	-0.9
Unable to work because of sickness or disability	0.5	0.6	1.1	-0.6	-0.6	1.1
Irritable Bowel Disease (IBD)	0.4	1.0	1.6	0.5	-1.3	1.0
Ovarian Cancer	0.4	0.6	1.6	0.4	1.2	-0.2
Lupus	0.4	0.6	0.8	0.8	-0.9	0.4
Ulcerative Colitis	0.4	0.6	1.3	1.1	0.7	0.0
Blood Eosinophil Count	0.4	3.4	4.6	1.3	-1.9	2.1
Smoking Status	0.4	0.9	2.0	-0.5	-1.4	0.7
Diabetes (father)	0.4	0.5	1.1	0.7	1.0	-0.1
Leg fat-free mass (left)	0.4	2.2	2.9	1.6	-1.0	1.7
Relative age voice broke	0.4	0.6	1.7	-0.3	0.2	-1.3
Multivitamins +/- minerals	0.4	0.5	0.9	1.0	0.3	-0.6
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	0.9	0.1	-0.9	0.7
Leg predicted mass (left)	0.4	2.2	3.0	1.6	-1.1	1.7
Past tobacco smoking	0.4	0.7	1.7	-1.3	0.5	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	0.9	1.0	0.8	-0.5
Mouth/teeth dental problems	0.4	0.6	1.3	0.2	0.8	-1.1
Weight	0.4	2.2	3.3	0.9	-1.5	1.8
Hip circumference	0.4	1.6	2.4	1.1	-1.6	1.2
Hair/balding pattern: Pattern 3	0.4	0.6	0.9	1.0	-0.9	-0.3
Pulse rate	0.4	0.6	0.9	-0.5	-0.8	0.9
Hair/balding pattern: Pattern 4	0.4	1.0	2.7	0.3	0.6	-1.6
Medication for pain relief, constipation, heartburn	0.4	0.7	1.3	-0.3	0.8	-1.2
Medication: Blood pressure	0.4	0.7	1.4	-0.6	0.7	1.2
Had major operations	0.4	0.4	1.1	-1.0	0.2	0.4
Leg pain on walking	0.4	0.5	0.8	0.1	0.7	0.9
Illnesses of siblings: Diabetes	0.4	0.5	1.0	0.4	1.0	-0.5
Leg fat-free mass (right)	0.4	2.1	3.0	1.4	-1.1	1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	0.6	-0.8	-0.7	0.6
Osteoarthritis (self-reported)	0.4	0.5	0.7	0.7	-0.8	0.5
Leg predicted mass (right)	0.4	2.0	2.9	1.4	-0.9	1.7
Medication: Atorvastatin	0.4	0.5	1.2	-1.1	-0.1	0.6
Schizophrenia vs Biploar Disorder	0.3	0.4	1.1	0.0	-1.0	0.0
Neuroticism	0.3	0.6	1.7	-0.4	-1.3	0.1
Impedance of leg (right)	0.3	1.5	2.7	-1.7	-0.8	-1.0
Supplements: Glucosamine	0.3	0.4	1.1	0.3	-1.1	0.3
Number of live births	0.3	0.5	0.7	-0.7	0.8	0.4
Medication: Cholesterol lowering	0.3	0.4	0.7	-0.8	0.4	0.6
Lung cancer (father)	0.3	0.3	0.7	0.3	-0.8	-0.5
Length of working week for main job	0.3	0.3	0.8	0.2	-0.2	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	0.6	-0.6	0.8	0.5
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.5	-0.6	0.7	-0.5
Hypothyroidism/myxoedema (self-reported)	0.3	0.7	1.4	-1.2	-0.5	0.5
Leg fat percentage (right)	0.3	0.9	1.6	-0.1	-1.1	1.2
Leg fat mass (right)	0.3	1.1	2.1	0.4	-1.0	1.4
Suffer from ‘nerves’	0.3	0.4	1.1	-0.2	1.1	-0.0
Family relationship satisfaction	0.3	0.4	0.6	-0.5	-0.8	0.6
Friendships satisfaction	0.3	0.4	1.0	-1.0	0.0	0.2
Illnesses of father: None of the above (group 1)	0.3	0.3	0.8	0.3	-0.3	-0.9
Guilty feelings	0.3	0.5	1.2	-0.4	-0.0	-1.1
Medication: Paracetamol	0.3	0.5	0.5	0.7	0.7	0.6
Alcohol drinker status: Never	0.3	0.3	0.7	0.4	0.4	-0.8
Leg fat percentage (left)	0.3	1.2	1.8	-0.5	-1.4	1.2
Risk taking	0.3	0.4	1.0	-0.5	-1.0	0.3
Leg fat mass (left)	0.3	1.3	2.3	0.3	-1.2	1.5
Bipolar Disorder or Schizophrenia	0.2	0.4	1.0	-0.1	1.0	0.2
Height	0.2	4.2	8.2	1.1	-2.9	1.7
Respiratory disease	0.2	0.5	0.8	-0.2	0.8	-0.9
Lung FEV1/FVC ratio	0.2	0.9	0.9	-1.0	0.9	-0.9
Average weekly fortified wine intake	0.2	0.2	0.6	-0.8	0.3	0.1
Taking other prescription medications	0.2	0.3	0.7	-0.8	0.1	0.5
Sitting height	0.2	1.7	4.5	0.8	-2.1	0.3
Body mass index (BMI)	0.2	1.0	2.2	0.5	-0.6	1.5
Waist circumference	0.2	0.6	1.3	0.7	-0.4	1.1
Financial difficulties in last 2 years	0.2	0.3	0.6	-0.6	0.0	0.8
Neuroticism score	0.2	0.4	0.6	-0.6	-0.8	-0.2
Illnesses of mother	0.2	0.3	0.5	0.6	0.1	-0.7
Arm fat mass (right)	0.2	0.6	1.3	0.5	-0.6	1.1
Standing height	0.2	1.7	3.6	0.9	-1.9	0.9
Qualifications: College or University degree	0.2	0.6	1.6	0.1	1.3	-0.5
Medication: Allopurinol	0.2	0.2	0.4	0.4	-0.6	0.3
Whole body fat mass	0.2	0.7	1.5	0.1	-1.2	0.8
Number of full sisters	0.2	0.2	0.3	-0.6	-0.4	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.4	0.4	0.6	-0.1
Loneliness, isolation	0.2	0.2	0.7	0.1	-0.8	0.1
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.8	-0.3	0.3	-0.9
Mineral and other dietary supplements	0.2	0.3	0.3	-0.5	0.5	-0.6
Arm fat mass (left)	0.2	0.7	1.3	0.4	-0.7	1.1
Number of self-reported non-cancer illnesses	0.2	0.4	1.0	-0.1	0.2	1.0
Miserableness	0.2	0.3	0.4	0.2	-0.5	-0.7
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.6	0.3	-0.8	-0.2
Pack years of smoking	0.2	0.3	0.7	-0.5	-0.2	0.9
Depressed Affect (Nagel 2018)	0.1	0.2	0.6	0.3	-0.7	0.3
Depression (Nagel 2018)	0.1	0.1	0.2	-0.3	-0.5	0.3
Neuroticism (Nagel 2018)	0.1	0.2	0.4	-0.6	-0.3	-0.4
Schizophrenia (2018)	0.1	0.3	0.5	0.6	0.0	0.7
Worry (Nagel 2018)	0.1	0.1	0.3	-0.6	0.2	-0.3
Ulcerative Colitis (UC)	0.1	0.2	0.4	0.3	-0.3	0.6
Mean Putamen Volume	0.1	0.1	0.2	-0.3	-0.4	-0.3
Primary Biliary Cirrhosis	0.1	0.2	0.4	-0.2	-0.6	-0.3
Schizophrenia (2014)	0.1	0.2	0.4	-0.0	-0.2	0.6
BMI	0.1	0.6	1.5	-0.1	-0.6	1.2
Hair Pigment	0.1	2.2	6.0	0.5	0.6	-2.4
Trunk fat percentage	0.1	0.2	0.7	-0.1	-0.8	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.2	-0.1	-0.5	-0.0
Trunk fat mass	0.1	0.5	1.2	0.3	-1.1	0.6
Hair/balding pattern: Pattern 2	0.1	0.2	0.5	-0.7	-0.0	0.2
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.3	-0.2	0.6	-0.4
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.4	-0.5	0.6	0.3
Depression (self-reported)	0.1	0.1	0.1	-0.0	0.3	-0.4
Breastfed as a baby	0.1	0.2	0.3	0.5	-0.2	0.4
Medication: Paracetamol	0.1	0.2	0.3	0.3	0.5	-0.5
Body fat percentage	0.1	0.4	0.9	-0.3	-0.9	0.3
Exposure to tobacco smoke outside home	0.1	0.2	0.4	-0.2	0.7	-0.2
Emphysema/chronic bronchitis	0.1	0.1	0.1	-0.4	0.2	0.1
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.2	-0.4	-0.5	0.1
Eye problems/disorders: Glaucoma	0.1	0.1	0.2	0.1	0.3	-0.4
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.2	0.1	0.5	0.4
Illnesses of father: High blood pressure	0.1	0.2	0.4	0.2	0.3	0.6
Ever smoked	0.1	0.2	0.4	0.2	-0.4	-0.6
Alzheimer’s Disease (in father)	0.0	0.0	0.1	-0.1	0.3	0.2
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	-0.0	0.0
Rheumatoid Arthritis	0.0	0.0	0.0	-0.1	0.2	0.1
Tanning	0.0	0.2	0.3	0.1	-0.4	-0.6
Illnesses of siblings	0.0	0.0	0.1	-0.0	0.1	-0.4
Arm fat percentage (right)	0.0	0.0	0.0	0.0	0.0	0.2
Glaucoma (self-reported)	0.0	0.0	0.1	0.1	0.1	-0.2
Arm fat percentage (left)	0.0	0.1	0.3	0.2	-0.2	0.5
Medication: Lisinopril	0.0	0.0	0.0	0.2	-0.1	-0.0

Hub : Genes

LPAR5

Models

Trait associations