Hub : Genes

LPAR5

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Testis 0.4300 0.099 2.9e-05 0.197 NA 0.119 NA 0.178 3.9e-09 NA 6.1e-06 NA 2.4e-08
2 METSIM Adipose 0.0623 0.023 4.4e-04 -0.001 0.017 -0.002 0.015 -0.002 6.4e-01 0.0011 7.5e-01 0.0023 9.3e-01
3 TCGA Colon Adenocarcinoma 0.0510 0.033 9.4e-03 0.027 0.025 0.010 NA 0.017 9.8e-03 0.0130 8.4e-02 NA 3.3e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.7 1.0 2.1 -1.0 1.4 0.0
Bipolar Disorder or Schizophrenia 0.2 0.4 1.0 -0.1 1.0 0.2
Depressed Affect (Nagel 2018) 0.1 0.2 0.6 0.3 -0.7 0.3
Depression (Nagel 2018) 0.1 0.1 0.2 -0.3 -0.5 0.3
Intelligence (Savage-Jansen 2018) 1.0 2.9 5.0 0.8 -1.8 2.2
Neuroticism (Nagel 2018) 0.1 0.2 0.4 -0.6 -0.3 -0.4
Schizophrenia (2018) 0.1 0.3 0.5 0.6 0.0 0.7
Schizophrenia vs Biploar Disorder 0.3 0.4 1.1 0.0 -1.0 0.0
Worry (Nagel 2018) 0.1 0.1 0.3 -0.6 0.2 -0.3
Alzheimer’s Disease (in mother) 1.7 2.0 3.9 -2.0 0.5 -1.4
Alzheimer’s Disease (in father) 0.0 0.0 0.1 -0.1 0.3 0.2
Alzheimer’s Disease (including proxy) 1.5 2.2 3.8 -1.9 1.0 -1.3
Crohns Disease (2017) 0.7 1.6 4.0 0.1 -2.0 1.0
Irritable Bowel Disease (IBD) 0.4 1.0 1.6 0.5 -1.3 1.0
Ulcerative Colitis (UC) 0.1 0.2 0.4 0.3 -0.3 0.6
Major Depression (MDD) 0.6 0.7 1.0 1.0 -1.0 0.4
Reaction Time 3.2 6.2 14.2 1.0 1.8 -3.8
Verbal and Numeric Reasoning (VNR) 0.5 1.1 1.6 1.3 -0.8 1.1
Breast Cancer 0.0 0.0 0.0 0.0 0.0 0.0
Ovarian Cancer 0.4 0.6 1.6 0.4 1.2 -0.2
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.9 1.4 2.9 -0.6 1.7 -0.9
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.9 1.2 3.5 0.0 0.3 1.9
Coronary Artery Disease (CAD) 0.0 0.0 0.0 0.0 -0.0 0.0
Crohns Disease (2012) 0.5 0.9 1.5 1.2 -1.1 0.0
Mean Putamen Volume 0.1 0.1 0.2 -0.3 -0.4 -0.3
Fasting Glucose 1.0 1.2 3.1 0.6 1.8 0.2
HbA1C 1.7 1.9 4.0 -2.0 -0.8 -1.1
HDL Cholesterol 1.2 2.0 5.2 -0.7 0.6 -2.3
LDL Cholesterol 0.8 1.3 3.7 -1.9 -0.3 -0.4
Lupus 0.4 0.6 0.8 0.8 -0.9 0.4
Neuroticism (2016) 1.6 2.3 5.0 0.7 -2.2 1.1
Primary Biliary Cirrhosis 0.1 0.2 0.4 -0.2 -0.6 -0.3
Rheumatoid Arthritis 0.0 0.0 0.0 -0.1 0.2 0.1
Schizophrenia (2014) 0.1 0.2 0.4 -0.0 -0.2 0.6
Triglycerides 0.9 1.4 3.4 0.9 0.3 1.8
Type 2 Diabetes (T2D) (2012) 0.5 0.6 1.5 -0.5 -1.2 0.0
Ulcerative Colitis 0.4 0.6 1.3 1.1 0.7 0.0
Blood Eosinophil Count 0.4 3.4 4.6 1.3 -1.9 2.1
Blood Platelet Count 2.0 23.3 60.4 1.4 7.8 2.7
Blood Red Count 1.3 12.9 26.5 3.3 -1.2 5.2
Blood White Count 0.5 3.6 5.0 -2.2 -1.0 2.2
Heel T-Score 2.4 19.1 33.3 -0.4 -4.9 5.8
BMI 0.1 0.6 1.5 -0.1 -0.6 1.2
Height 0.2 4.2 8.2 1.1 -2.9 1.7
Waist Hip Ratio (WHR) 0.5 2.5 7.3 -0.1 2.7 -0.2
Systolic Blood Pressure 1.1 5.3 10.6 0.0 -2.3 3.2
Smoking Status 0.4 0.9 2.0 -0.5 -1.4 0.7
Allergy or Eczema 2.1 5.6 13.8 0.2 3.7 -1.7
Cardiovascular Disease 1.3 4.4 7.1 -2.7 -0.6 2.4
Hypothyroidism (self reported) 0.5 1.2 3.0 -0.4 -0.7 1.7
Respiratory disease 0.2 0.5 0.8 -0.2 0.8 -0.9
Type 2 Diabetes (T2D) (2018) 2.4 4.5 11.4 -0.5 -1.4 3.4
Lung FEV1/FVC ratio 0.2 0.9 0.9 -1.0 0.9 -0.9
Lung FVC 1.6 8.0 20.2 4.5 1.6 -1.1
Neuroticism 0.3 0.6 1.7 -0.4 -1.3 0.1
Chronotype (morning person) 0.6 1.3 1.9 1.4 -1.4 -0.1
Hair Pigment 0.1 2.2 6.0 0.5 0.6 -2.4
Tanning 0.0 0.2 0.3 0.1 -0.4 -0.6
Hand grip strength (left) 0.5 1.3 3.2 -0.8 -1.8 0.1
Number of treatments/medications taken 0.7 1.2 3.4 -0.0 -0.4 1.9
Average weekly spirits intake 1.6 2.0 3.1 -1.0 -1.4 1.8
Sensitivity / hurt feelings 0.5 0.8 1.8 0.1 0.7 -1.4
Frequency of depressed mood in last 2 weeks 0.5 0.7 1.5 -0.5 -1.2 -0.7
Hearing difficulty/problems: Yes 1.9 2.9 4.7 2.2 1.7 1.1
Relative age of first facial hair 0.7 1.3 2.0 -1.4 0.4 -1.4
Other serious medical condition/disability diagnosed by doctor 1.0 1.3 2.9 0.8 -0.6 1.7
Ever used hormone-replacement therapy (HRT) 1.0 1.2 3.3 1.8 0.6 0.0
Ever had hysterectomy (womb removed) 0.5 0.6 1.3 0.0 1.1 0.7
Systolic blood pressure, automated reading 1.0 3.0 8.1 0.2 -0.9 2.8
Eye problems/disorders: Diabetes related eye disease 3.8 4.2 8.7 -0.4 -1.9 3.0
Angina 2.6 3.4 5.8 2.0 -0.4 2.4
Medication for hormone replacement therapy 1.1 1.2 3.6 1.9 0.1 -0.3
Vitamin and mineral supplements 1.2 1.7 4.5 -2.1 -0.1 0.7
Supplements: Zinc 1.6 1.7 2.6 -1.3 0.9 1.6
Medication: Co-codamol 0.8 1.0 1.8 -1.3 0.8 -0.6
Medication: Metformin 1.2 1.6 4.7 -0.4 -0.1 2.2
Diabetes (father) 0.4 0.5 1.1 0.7 1.0 -0.1
Diabetes (mother) 0.6 0.8 1.2 0.1 -1.1 1.1
Severe depression (siblings) 0.7 0.7 1.1 0.3 1.0 1.0
Pack years adult smoking proportion 0.5 0.7 1.4 -0.7 -0.6 1.2
Impedance of leg (right) 0.3 1.5 2.7 -1.7 -0.8 -1.0
Leg fat-free mass (left) 0.4 2.2 2.9 1.6 -1.0 1.7
Trunk fat percentage 0.1 0.2 0.7 -0.1 -0.8 0.0
Hand grip strength (right) 1.0 2.7 6.2 0.8 -2.5 1.1
Townsend deprivation index at recruitment 2.0 2.8 6.0 -1.5 2.4 -0.3
Current tobacco smoking 0.7 1.2 3.5 -1.9 0.2 -0.1
Average weekly fortified wine intake 0.2 0.2 0.6 -0.8 0.3 0.1
Maternal smoking around birth 0.5 0.8 1.4 1.2 0.9 -0.2
Fed-up feelings 0.7 1.3 2.1 0.3 -1.3 1.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.1 0.2 -0.1 -0.5 -0.0
Relative age voice broke 0.4 0.6 1.7 -0.3 0.2 -1.3
Taking other prescription medications 0.2 0.3 0.7 -0.8 0.1 0.5
Age when periods started (menarche) 2.8 6.6 12.7 -2.6 0.8 -3.6
Bilateral oophorectomy (both ovaries removed) 1.0 1.2 3.0 0.7 1.7 0.3
Heel bone mineral density (BMD) T-score, automated (left) 1.5 3.4 5.8 1.0 -1.8 2.4
Tinnitus: Yes, but not now, but have in the past 1.3 1.3 2.9 1.0 0.4 1.7
Qualifications: CSEs or equivalent 2.4 3.2 5.8 1.9 -0.1 2.4
Serious illness, injury or assault to yourself 5.0 6.0 10.7 0.4 -3.3 2.7
High blood pressure 1.1 3.0 8.4 -0.7 0.4 2.9
Hayfever, allergic rhinitis or eczema 1.3 2.9 5.3 -0.6 2.3 -1.7
Multivitamins +/- minerals 0.4 0.5 0.9 1.0 0.3 -0.6
Stomach or abdominal pain in last month 1.4 1.8 4.9 0.7 0.1 2.2
Supplements: Glucosamine 0.3 0.4 1.1 0.3 -1.1 0.3
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 0.9 0.1 -0.9 0.7
Medication: Atenolol 0.6 0.8 1.3 -1.0 -1.1 -0.3
Medication: Levothyroxine sodium 0.7 1.2 2.9 -0.1 -0.8 1.7
Sitting height 0.2 1.7 4.5 0.8 -2.1 0.3
Chronic bronchitis/emphysema (father) 3.5 4.1 9.9 -0.3 -3.1 1.5
High blood pressure (mother) 1.6 2.3 4.0 1.1 1.2 2.0
Body mass index (BMI) 0.2 1.0 2.2 0.5 -0.6 1.5
Impedance of leg (left) 0.5 2.6 5.2 -2.3 -1.1 -1.2
Leg predicted mass (left) 0.4 2.2 3.0 1.6 -1.1 1.7
Trunk fat mass 0.1 0.5 1.2 0.3 -1.1 0.6
Waist circumference 0.2 0.6 1.3 0.7 -0.4 1.1
Number of incorrect matches in round 0.7 1.1 3.2 0.0 0.3 -1.8
Past tobacco smoking 0.4 0.7 1.7 -1.3 0.5 -0.2
Alcohol usually taken with meals 0.9 1.5 2.2 0.7 1.5 -1.3
Nervous feelings 0.5 1.0 2.3 -0.6 1.5 0.4
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 0.9 1.0 0.8 -0.5
Hearing difficulty/problems with background noise 2.2 3.5 7.3 2.7 1.5 0.9
Hair/balding pattern: Pattern 2 0.1 0.2 0.5 -0.7 -0.0 0.2
Had menopause 0.6 0.8 1.4 1.0 1.2 -0.0
Had other major operations 2.3 2.8 4.9 1.9 0.3 2.2
Forced vital capacity (FVC) 1.6 6.1 15.2 3.9 -1.0 1.5
Heel bone mineral density (BMD) T-score, automated (right) 2.1 4.7 8.0 1.0 -2.8 2.3
Ever unenthusiastic/disinterested for a whole week 0.1 0.2 0.3 -0.2 0.6 -0.4
Qualifications: None of the above 1.8 3.9 8.2 -1.6 -2.9 -0.9
Financial difficulties in last 2 years 0.2 0.3 0.6 -0.6 0.0 0.8
Mouth/teeth dental problems 0.4 0.6 1.3 0.2 0.8 -1.1
Heart attack 0.8 1.1 2.7 0.2 -1.6 0.7
Allergy 2.2 5.1 6.7 1.4 -2.6 2.6
Pain all over the body in last month 1.7 1.8 3.1 -1.1 1.1 -1.8
Diabetes (self-reported) 3.4 5.3 12.8 -1.0 -1.4 3.6
Hayfever/allergic rhinitis (self-reported) 1.9 2.5 6.0 -0.6 1.0 -2.5
Medication: Ramipril 1.2 1.5 3.9 -0.0 -0.8 2.0
Medication: Simvastatin 2.1 3.1 4.7 1.6 -1.4 2.2
Fluid intelligence score 0.5 1.0 1.9 0.5 -1.0 1.4
Illnesses of siblings 0.0 0.0 0.1 -0.0 0.1 -0.4
Neuroticism score 0.2 0.4 0.6 -0.6 -0.8 -0.2
Weight 0.4 2.2 3.3 0.9 -1.5 1.8
Impedance of arm (right) 1.1 5.1 13.0 -0.9 1.2 -3.6
Arm fat percentage (right) 0.0 0.0 0.0 0.0 0.0 0.2
Trunk fat-free mass 0.7 4.0 8.1 1.4 -1.4 2.8
Hip circumference 0.4 1.6 2.4 1.1 -1.6 1.2
Time employed in main current job 0.6 0.7 1.5 -0.8 0.1 -1.2
Alcohol intake versus 10 years previously 1.1 1.6 3.0 1.7 -0.2 1.3
Father’s age at death 0.6 0.8 2.1 1.5 0.5 0.4
Worrier / anxious feelings 0.5 0.9 1.4 -0.6 -1.2 0.9
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.9 1.9 -1.4 -0.5 0.7
Falls in the last year 0.5 0.6 1.6 0.5 -1.3 -0.2
Hair/balding pattern: Pattern 3 0.4 0.6 0.9 1.0 -0.9 -0.3
Number of live births 0.3 0.5 0.7 -0.7 0.8 0.4
Forced expiratory volume in 1-second (FEV1) 1.2 4.1 11.6 3.4 0.0 0.9
Pulse rate 0.4 0.6 0.9 -0.5 -0.8 0.9
Happiness 1.8 2.2 4.3 -1.5 -0.5 2.1
Noisy workplace 1.1 1.4 2.7 0.9 1.6 0.7
Qualifications: A levels/AS levels or equivalent 0.1 0.3 0.4 -0.5 0.6 0.3
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 1.9 -1.4 -0.3 -0.2
Mouth/teeth dental problems: Dentures 2.6 4.3 8.0 1.7 -1.5 2.8
Asthma 1.1 2.2 4.5 -1.2 0.8 -2.1
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.6 0.9 -1.0 -0.9 0.0
Medication: Cholesterol lowering 0.3 0.4 0.7 -0.8 0.4 0.6
Depression (self-reported) 0.1 0.1 0.1 -0.0 0.3 -0.4
Medication: Lansoprazole 0.9 1.0 1.8 1.3 -1.0 0.3
Prospective memory result 0.6 0.7 1.8 -1.4 0.4 0.3
Lung cancer (father) 0.3 0.3 0.7 0.3 -0.8 -0.5
Illnesses of mother 0.2 0.3 0.5 0.6 0.1 -0.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.9 2.9 8.5 2.9 0.5 0.1
Pulse wave Arterial Stiffness index 1.9 2.2 3.5 1.8 0.1 1.9
Impedance of arm (left) 0.8 3.5 9.5 -0.8 0.6 -3.1
Arm fat mass (right) 0.2 0.6 1.3 0.5 -0.6 1.1
Trunk predicted mass 0.7 3.8 7.8 1.3 -1.4 2.8
Standing height 0.2 1.7 3.6 0.9 -1.9 0.9
Length of working week for main job 0.3 0.3 0.8 0.2 -0.2 -0.9
Exposure to tobacco smoke at home 1.1 1.3 3.4 -0.2 1.8 0.6
Breastfed as a baby 0.1 0.2 0.3 0.5 -0.2 0.4
Tense / ‘highly strung’ 0.8 1.4 3.9 -2.0 0.0 -0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.4 0.6 -0.6 0.8 0.5
Hair/balding pattern: Pattern 4 0.4 1.0 2.7 0.3 0.6 -1.6
Birth weight of first child 0.7 1.3 2.7 0.3 1.1 1.7
Peak expiratory flow (PEF) 0.6 1.3 3.7 1.9 0.5 -0.2
Pulse wave reflection index 1.4 1.8 3.6 1.9 0.2 1.3
Ever highly irritable/argumentative for 2 days 0.3 0.4 0.5 -0.6 0.7 -0.5
Loud music exposure frequency 0.7 0.7 1.4 -0.6 0.6 -1.2
Qualifications: O levels/GCSEs or equivalent 2.3 3.6 9.7 0.6 0.8 3.1
Mouth/teeth dental problems: Bleeding gums 0.9 1.2 3.2 -1.8 0.5 0.4
Blood clot in the leg (DVT) 1.1 1.4 2.6 -0.9 0.9 -1.6
Medication: Paracetamol 0.1 0.2 0.3 0.3 0.5 -0.5
Headache pain in last month 0.6 1.1 2.4 1.0 -1.5 -0.2
Medication for cholesterol, blood pressure or diabetes 0.5 0.8 1.4 1.2 0.2 -1.0
Glaucoma (self-reported) 0.0 0.0 0.1 0.1 0.1 -0.2
Gout (self-reported) 0.9 1.2 2.5 -0.0 -1.6 1.0
Hypothyroidism/myxoedema (self-reported) 0.3 0.7 1.4 -1.2 -0.5 0.5
Medication: Amlodipine 0.9 1.2 2.0 1.1 1.4 -0.5
Medication: Ventolin 100micrograms inhaler 1.2 1.6 2.6 -1.4 -1.6 -0.3
Birth weight 1.1 2.3 5.9 -2.4 -0.3 -1.0
Chronic bronchitis/emphysema (mother) 0.9 1.1 1.9 -0.0 1.4 -1.1
High blood pressure (siblings) 0.7 1.0 2.4 0.9 0.1 1.5
Forced vital capacity (FVC), Best measure 1.0 3.6 10.3 3.2 -0.4 0.7
Body fat percentage 0.1 0.4 0.9 -0.3 -0.9 0.3
Leg fat percentage (right) 0.3 0.9 1.6 -0.1 -1.1 1.2
Arm fat-free mass (right) 1.0 5.1 9.9 1.4 -1.8 3.1
Exposure to tobacco smoke outside home 0.1 0.2 0.4 -0.2 0.7 -0.2
Comparative body size at age 10 0.6 1.6 3.0 -1.3 0.5 -1.7
Number of full brothers 0.7 0.9 1.2 0.5 -1.1 1.1
Worry too long after embarrassment 0.5 0.8 1.6 -0.5 -1.3 0.8
Seen a psychiatrist for nerves, anxiety, tension or depression 1.2 1.5 3.9 0.8 2.0 -0.1
Wheeze or whistling in the chest in last year 1.0 1.8 3.6 -1.9 -1.0 -0.9
Number of children fathered 2.0 2.2 4.1 -1.6 -2.0 -0.2
Reason for reducing amount of alcohol drunk: Health precaution 1.3 1.6 4.4 0.4 0.4 2.1
Age at first live birth 1.0 1.8 4.9 -0.6 -0.3 -2.2
Pulse wave peak to peak time 1.7 2.0 3.1 -1.7 -0.4 -1.8
Health satisfaction 2.0 2.6 7.0 -0.0 -1.0 2.6
Shortness of breath walking on level ground 0.6 0.7 1.3 0.5 -1.1 0.6
Qualifications: College or University degree 0.2 0.6 1.6 0.1 1.3 -0.5
Eye problems/disorders: None of the above 2.1 2.4 6.3 -0.9 0.1 -2.5
Mouth/teeth dental problems: Loose teeth 1.7 2.0 4.4 0.6 -1.1 2.1
Emphysema/chronic bronchitis 0.1 0.1 0.1 -0.4 0.2 0.1
Medication for pain relief, constipation, heartburn 0.4 0.7 1.3 -0.3 0.8 -1.2
Neck or shoulder pain in last month 3.8 5.3 10.3 0.9 -2.2 3.2
Medication: Blood pressure 0.4 0.7 1.4 -0.6 0.7 1.2
Angina (self-reported) 3.0 4.0 6.6 2.3 -0.4 2.6
Migraine (self-reported) 0.6 0.7 1.1 0.3 1.0 -1.0
Medication: Ibuprofen 0.9 1.1 1.7 -1.3 -1.3 0.2
Medication: Allopurinol 0.2 0.2 0.4 0.4 -0.6 0.3
Medication: Omeprazole 0.5 0.6 1.3 0.2 0.6 1.1
Medication: Seretide 50 evohaler 2.3 2.6 5.7 -1.4 0.3 -2.4
Mean time to correctly identify matches 3.3 6.3 11.6 1.7 2.1 -3.4
Heart disease (mother) 0.7 0.8 2.0 1.4 -0.4 0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 0.8 -0.9 0.8 -0.6
Whole body fat mass 0.2 0.7 1.5 0.1 -1.2 0.8
Leg fat mass (right) 0.3 1.1 2.1 0.4 -1.0 1.4
Arm predicted mass (right) 0.9 4.4 8.7 1.3 -1.7 3.0
Pulse rate, automated reading 0.9 2.9 7.0 1.1 -0.7 2.7
Alcohol intake frequency. 0.9 2.0 5.7 2.4 0.5 -0.1
Comparative height size at age 10 0.8 4.6 6.8 1.0 -2.6 2.4
Number of full sisters 0.2 0.2 0.3 -0.6 -0.4 -0.3
Suffer from ‘nerves’ 0.3 0.4 1.1 -0.2 1.1 -0.0
Overall health rating 1.0 2.2 5.9 0.8 -0.2 2.4
Chest pain or discomfort 2.5 3.6 5.2 -0.7 -2.2 2.3
Had major operations 0.4 0.4 1.1 -1.0 0.2 0.4
Age at last live birth 2.9 4.2 6.8 -1.7 1.7 -2.6
Family relationship satisfaction 0.3 0.4 0.6 -0.5 -0.8 0.6
Leg pain on walking 0.4 0.5 0.8 0.1 0.7 0.9
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.8 2.1 1.5 0.3 0.4
Commuting to job workplace: Car/motor vehicle 1.0 1.1 3.1 0.2 -1.8 -0.5
Illness, injury, bereavement, stress in last 2 years 0.1 0.1 0.2 -0.4 -0.5 0.1
Medication: Aspirin 0.7 0.9 1.6 0.7 -1.3 0.8
Supplements: Vitamin C 0.5 0.6 1.1 0.8 0.1 1.0
Knee pain experienced in last month 0.9 1.5 4.1 0.2 0.5 2.0
Hypertension (Self-reported) 1.3 3.5 9.7 -0.8 0.3 3.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.2 0.4 0.4 0.6 -0.1
Illnesses of father: Heart disease 1.0 1.4 2.2 1.1 0.9 1.5
Illnesses of siblings: Diabetes 0.4 0.5 1.0 0.4 1.0 -0.5
Smoking status: Previous 1.3 1.9 4.6 2.1 -0.7 0.7
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.1 2.9 1.7 -0.1 0.5
Whole body fat-free mass 0.6 3.4 6.5 1.4 -1.3 2.5
Leg fat-free mass (right) 0.4 2.1 3.0 1.4 -1.1 1.7
Arm fat percentage (left) 0.0 0.1 0.3 0.2 -0.2 0.5
Average weekly red wine intake 1.5 2.2 5.7 -2.4 -0.4 -0.9
Handedness (chirality/laterality): Left-handed 0.6 0.7 1.0 -1.0 -1.0 0.5
Mood swings 1.0 1.7 3.4 -1.3 0.2 -1.9
Loneliness, isolation 0.2 0.2 0.7 0.1 -0.8 0.1
Long-standing illness, disability or infirmity 1.8 2.8 5.4 1.5 -1.0 2.3
Ever had bowel cancer screening 1.0 1.2 3.3 -0.5 0.2 1.8
Diabetes diagnosed by doctor 2.7 4.5 10.1 -0.8 -1.6 3.2
Ever had stillbirth, spontaneous miscarriage or termination 3.6 3.8 5.5 -2.2 1.0 -2.3
Friendships satisfaction 0.3 0.4 1.0 -1.0 0.0 0.2
Qualifications: nursing, teaching 0.7 1.1 1.7 0.5 1.1 -1.3
Commuting to job workplace: Walk 2.9 3.2 8.6 0.7 0.6 2.9
Eye problems/disorders: Cataract 1.3 1.5 2.8 0.7 -1.0 1.7
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 0.8 -0.3 0.3 -0.9
Medication for cholesterol 0.5 0.8 1.3 -0.4 1.2 -0.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.5 0.6 -0.8 -0.7 0.6
Back pain experienced in last month 3.8 5.5 9.7 0.5 -3.1 2.6
Mineral and other dietary supplements 0.2 0.3 0.3 -0.5 0.5 -0.6
Breast cancer (self-reported) 2.5 3.0 3.6 1.4 -1.9 1.8
Asthma (self-reported) 1.1 2.1 4.5 -1.3 0.6 -2.1
Osteoporosis (self-reported) 3.8 4.7 5.8 1.8 2.2 -2.4
Osteoarthritis (self-reported) 0.4 0.5 0.7 0.7 -0.8 0.5
Medication: Aspirin 1.1 1.4 3.0 0.8 -1.7 0.8
Medication: Gliclazide 1.7 1.9 3.8 -1.2 0.5 1.9
Illnesses of father: None of the above (group 1) 0.3 0.3 0.8 0.3 -0.3 -0.9
Smoking status: Current 0.8 1.2 3.6 -1.9 0.1 0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.2 2.5 5.8 2.4 1.3 -0.4
Whole body water mass 0.7 3.9 7.7 1.5 -1.4 2.8
Leg predicted mass (right) 0.4 2.0 2.9 1.4 -0.9 1.7
Arm fat mass (left) 0.2 0.7 1.3 0.4 -0.7 1.1
Number of self-reported non-cancer illnesses 0.2 0.4 1.0 -0.1 0.2 1.0
Average weekly champagne plus white wine intake 0.8 1.1 2.0 0.5 1.4 -0.9
Miserableness 0.2 0.3 0.4 0.2 -0.5 -0.7
Guilty feelings 0.3 0.5 1.2 -0.4 -0.0 -1.1
Wears glasses or contact lenses 0.9 1.0 3.0 0.2 1.7 -0.3
Ever taken oral contraceptive pill 1.1 1.2 2.0 -0.6 -1.4 1.2
Hearing aid user 1.1 1.3 2.4 1.0 -1.5 -0.7
Mother’s age at death 1.3 1.7 3.9 0.3 2.0 -1.0
Financial situation satisfaction 1.3 1.7 4.6 0.2 -0.5 2.1
Tinnitus: Yes, now most or all of the time 0.2 0.3 0.6 0.3 -0.8 -0.2
Commuting to job workplace: Public transport 2.2 2.6 3.0 -1.6 1.5 -1.7
Eye problems/disorders: Glaucoma 0.1 0.1 0.2 0.1 0.3 -0.4
Medication: Blood pressure 0.9 1.7 4.2 0.4 -0.9 2.0
Pain type(s) experienced in last month: Hip pain 0.1 0.1 0.2 0.1 0.5 0.4
Supplements: Fish oil (including cod liver oil) 0.7 0.9 1.3 0.8 -0.9 1.2
High cholesterol (Self-reported) 0.7 1.2 2.4 -1.6 -1.1 0.3
Medication: Bendroflumethiazide 1.3 1.9 2.7 0.9 -1.5 1.6
Medication: Paracetamol 0.3 0.5 0.5 0.7 0.7 0.6
Medication: Lisinopril 0.0 0.0 0.0 0.2 -0.1 -0.0
Medication: Atorvastatin 0.4 0.5 1.2 -1.1 -0.1 0.6
Illnesses of father: High blood pressure 0.1 0.2 0.4 0.2 0.3 0.6
Alcohol drinker status: Never 0.3 0.3 0.7 0.4 0.4 -0.8
Ever smoked 0.1 0.2 0.4 0.2 -0.4 -0.6
Basal metabolic rate 0.6 3.2 5.9 1.3 -1.4 2.4
Leg fat percentage (left) 0.3 1.2 1.8 -0.5 -1.4 1.2
Arm fat-free mass (left) 0.7 3.5 7.7 1.0 -1.4 2.8
Number of operations (self-reported) 1.6 2.3 4.6 1.4 -0.8 2.1
Average weekly beer plus cider intake 1.2 1.7 3.4 -1.8 -0.7 -1.1
Irritability 1.2 2.1 3.6 -1.9 -0.1 -1.6
Risk taking 0.3 0.4 1.0 -0.5 -1.0 0.3
Ever had prostate specific antigen (PSA) test 0.9 1.0 1.8 1.1 -0.3 1.4
Fractured/broken bones in last 5 years 1.3 1.7 1.9 1.2 1.3 -1.4
Age started oral contraceptive pill 0.7 0.9 1.8 -0.2 1.3 -0.9
Diastolic blood pressure, automated reading 0.9 2.9 5.8 1.6 -0.6 2.4
Ever depressed for a whole week 1.0 1.2 1.5 -1.2 1.1 -1.0
Unable to work because of sickness or disability 0.5 0.6 1.1 -0.6 -0.6 1.1
Commuting to job workplace: Cycle 0.8 1.0 2.2 -0.7 -1.5 0.4
Myopia 1.4 2.0 3.5 1.5 1.9 -0.3
Vascular/heart problems diagnosed by doctor 1.0 2.7 7.9 0.5 0.0 -2.8
Cholesterol lowering medication 1.4 2.0 3.6 1.0 -1.2 1.9
Medication: Omeprazole (e.g. Zanprol) 0.6 0.7 1.2 0.5 1.1 0.8
Pain experienced in last month 1.2 2.0 3.3 0.2 1.6 -1.8
Supplements: Calcium 1.3 1.4 3.1 1.8 1.1 0.1
Basal cell carcinoma (self-reported) 0.6 0.7 1.2 -0.9 0.0 1.1
Heart attack/myocardial infarction (self-reported) 0.9 1.2 3.0 0.2 -1.7 0.7
Deep venous thrombosis (DVT) (self-reported) 1.6 2.0 4.8 -0.9 0.8 -2.2
Heart disease (siblings) 2.6 3.2 8.5 -0.5 -2.9 0.9
Alcohol drinker status: Previous 0.6 0.6 1.4 0.0 0.7 -1.2
Pack years of smoking 0.2 0.3 0.7 -0.5 -0.2 0.9
Impedance of whole body 0.8 4.2 8.7 -1.9 -0.1 -3.0
Leg fat mass (left) 0.3 1.3 2.3 0.3 -1.2 1.5
Arm predicted mass (left) 0.6 3.0 6.4 0.9 -1.4 2.5