TWAS hub - CLEC12B

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.2216	0.0416	5.6e-17	0.132	0.113	0.144	0.140	0.144	2.9e-19	1.7e-16	6.6e-21	2.7e-20	5.9e-21
2	NTR	Blood	0.1594	0.0255	0.0e+00	0.155	0.124	0.153	0.151	0.154	9.1e-48	9.6e-38	4.3e-47	2.9e-46	3.2e-47
3	TCGA	Breast Invasive Carcinoma	0.1594	0.0460	5.6e-17	0.081	0.095	0.093	NA	0.086	4.0e-16	6.7e-19	1.9e-18	NA	4.8e-17
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.1534	0.0452	7.4e-14	0.098	0.136	0.136	NA	0.144	4.2e-11	5.1e-15	4.2e-15	NA	6.5e-16
5	TCGA	Kidney Renal Papillary Cell Carcinoma	0.1740	0.0660	5.8e-06	0.187	0.091	0.139	NA	0.179	6.3e-11	6.7e-06	2.3e-08	NA	1.8e-10
6	TCGA	Brain Lower Grade Glioma	0.0284	0.0152	4.3e-04	0.033	0.027	0.023	NA	0.027	1.2e-04	4.4e-04	1.0e-03	NA	3.8e-04
7	TCGA	Lung Adenocarcinoma	0.0934	0.0346	1.4e-06	0.071	0.059	0.072	NA	0.070	9.9e-09	1.7e-07	8.3e-09	NA	1.2e-08
8	TCGA	Ovarian Serous Cystadenocarcinoma	0.1070	0.0430	4.0e-05	0.061	0.042	0.066	NA	0.046	6.1e-05	7.6e-04	3.2e-05	NA	4.3e-04
9	TCGA	Prostate Adenocarcinoma	0.0493	0.0235	2.6e-04	0.035	0.026	0.030	NA	0.037	1.3e-04	8.4e-04	3.4e-04	NA	9.3e-05
10	TCGA	Soft Tissue Sarcoma	0.1170	0.0570	3.4e-03	0.077	0.040	0.033	NA	0.064	2.4e-05	1.9e-03	4.7e-03	NA	1.2e-04
11	TCGA	Thyroid Carcinoma	0.1020	0.0390	1.2e-06	0.082	0.070	0.064	NA	0.070	2.1e-08	2.3e-07	7.4e-07	NA	2.5e-07

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Number of full brothers	6.7	8.5	11.0	3.2	3.1	3.1	3.0	3.0	1.6	3.2	2.7	2.4	3.0	3.3
Average weekly champagne plus white wine intake	5.3	7.2	9.7	-2.9	-2.3	-3.1	-3.0	-2.4	-2.0	-2.8	-2.3	-3.1	-2.4	-3.1
Rheumatoid Arthritis	4.5	6.2	9.3	-2.3	-2.4	-2.1	-3.0	-2.4	-2.6	-2.1	-2.2	-3.0	-2.4	-2.7
Happiness	3.6	4.4	7.6	2.4	1.6	2.1	2.4	1.7	1.1	2.8	2.0	2.4	1.7	2.3
Multivitamins +/- minerals	3.2	4.1	6.4	1.8	2.0	1.8	2.1	2.0	2.0	2.2	1.6	1.9	2.0	2.5
Crohns Disease (2017)	3.1	6.8	11.5	-3.4	-2.8	-3.0	-2.7	-2.8	-0.2	-2.7	-2.1	-2.1	-2.8	-2.7
Miserableness	2.9	5.0	6.9	2.5	2.6	2.1	2.3	2.6	0.7	2.5	2.3	1.7	2.6	1.9
Friendships satisfaction	2.7	3.4	6.0	1.7	1.3	2.0	2.2	1.4	1.4	2.1	1.6	2.5	1.4	2.2
Alcohol drinker status: Previous	2.7	3.1	5.5	-1.4	-2.1	-1.2	-1.6	-2.0	-1.8	-1.9	-2.3	-1.5	-2.0	-1.1
Irritable Bowel Disease (IBD)	2.5	5.9	9.9	-3.1	-2.4	-3.1	-2.8	-2.4	-0.6	-2.2	-1.4	-2.3	-2.4	-2.9
Hair/balding pattern: Pattern 2	2.4	3.1	4.3	1.6	1.9	1.1	1.9	1.9	1.9	1.6	2.1	1.8	1.9	1.5
Alzheimer’s Disease (including proxy)	2.2	3.2	5.3	1.9	2.3	1.4	1.9	2.2	1.2	1.2	1.9	1.5	2.2	1.5
Blood Eosinophil Count	2.2	17.1	22.2	3.7	4.4	4.0	4.1	4.5	3.5	4.3	4.7	3.8	4.5	3.9
Blood White Count	2.1	15.7	22.8	3.9	4.8	3.6	3.9	4.7	3.0	3.6	4.0	3.2	4.7	3.8
Medication: Ramipril	2.1	2.7	4.8	-1.2	-1.7	-1.2	-1.6	-1.6	-2.2	-1.6	-2.0	-1.6	-1.6	-1.6
Suffer from ‘nerves’	2.1	3.3	4.3	1.9	2.0	1.9	2.1	2.0	1.4	1.3	1.7	1.9	2.0	1.5
Eye problems/disorders: Diabetes related eye disease	2.0	2.2	8.3	-0.4	-1.6	-0.8	-1.1	-1.5	-2.9	-0.4	-2.1	-1.3	-1.5	-0.9
Medication for hormone replacement therapy	2.0	2.2	2.9	-1.6	-1.7	-1.6	-1.5	-1.7	-1.1	-1.4	-1.2	-1.2	-1.7	-1.7
Tinnitus: Yes, but not now, but have in the past	2.0	2.2	3.2	1.3	1.8	1.1	1.6	1.7	1.2	1.1	1.6	1.4	1.7	1.3
Medication for cholesterol	2.0	3.1	7.1	1.3	1.8	0.9	1.7	1.8	2.7	1.7	1.8	1.5	1.8	1.9
Pain all over the body in last month	1.9	2.1	3.4	1.1	1.2	1.3	1.7	1.3	1.8	0.9	1.4	1.8	1.3	1.7
Qualifications: NVQ or HND or HNC or equivalent	1.9	2.2	3.4	1.5	1.1	1.3	1.7	1.1	1.4	1.8	1.6	1.7	1.1	1.8
Coronary Artery Disease (CAD)	1.8	2.1	3.1	-1.5	-1.4	-1.5	-1.6	-1.4	-0.9	-1.8	-1.4	-1.5	-1.4	-1.6
Fractured/broken bones in last 5 years	1.8	2.3	5.1	1.8	1.5	1.5	1.5	1.5	0.3	2.2	1.3	1.2	1.5	1.4
Crohns Disease (2012)	1.6	2.6	4.5	-2.1	-1.6	-1.2	-1.6	-1.7	-0.1	-2.1	-1.7	-1.1	-1.7	-1.6
Chronotype (morning person)	1.6	3.8	5.5	-1.8	-2.0	-2.0	-1.8	-2.0	-1.7	-2.4	-1.9	-1.5	-2.0	-2.3
Current tobacco smoking	1.6	2.6	4.3	-1.9	-1.6	-1.5	-1.6	-1.6	-0.3	-1.9	-2.1	-1.5	-1.6	-1.2
Worry too long after embarrassment	1.6	2.6	3.7	1.4	1.9	0.8	1.7	1.9	1.9	1.4	1.8	1.4	1.9	1.3
Mouth/teeth dental problems: Mouth ulcers	1.6	2.5	4.6	1.0	1.5	1.6	1.6	1.5	2.1	0.8	2.1	1.8	1.5	1.2
Number of live births	1.5	2.2	4.6	-1.5	-2.1	-0.9	-1.1	-2.1	-0.0	-1.4	-2.0	-0.6	-2.1	0.0
Exposure to tobacco smoke at home	1.5	1.7	3.2	-1.1	-1.0	-0.7	-1.6	-1.1	-1.7	-1.4	-1.3	-1.8	-1.1	-1.3
Loud music exposure frequency	1.5	1.7	3.0	1.7	1.5	1.0	1.2	1.5	0.0	1.7	1.1	0.6	1.5	1.2
Health satisfaction	1.5	2.0	3.2	1.4	1.0	1.8	1.6	1.1	1.0	1.3	1.4	1.8	1.1	1.6
Commuting to job workplace: Cycle	1.5	1.8	3.1	1.3	1.4	1.3	1.4	1.4	0.9	1.8	1.3	1.0	1.4	1.6
Ulcerative Colitis (UC)	1.4	2.7	4.8	-2.0	-1.4	-2.2	-2.0	-1.5	-0.8	-1.1	-0.6	-1.8	-1.5	-2.2
HbA1C	1.4	1.5	2.7	-1.6	-1.5	-1.6	-1.2	-1.5	0.0	-1.0	-1.1	-0.9	-1.5	-0.9
Chronic bronchitis/emphysema (father)	1.4	1.7	3.4	0.9	0.9	1.2	1.5	0.9	1.4	0.9	1.5	1.8	0.9	1.7
Medication: Lansoprazole	1.4	1.6	4.3	-0.5	-0.7	-1.1	-1.5	-0.8	-1.9	-0.9	-1.4	-2.1	-0.8	-1.2
Birth weight	1.4	3.1	4.0	2.0	1.8	1.9	1.8	1.8	0.9	1.8	1.6	1.5	1.8	2.0
Emphysema/chronic bronchitis	1.4	1.6	3.9	-1.0	-0.8	-2.0	-1.5	-0.9	-0.8	-1.1	-1.2	-1.8	-0.9	-1.3
Leg pain on walking	1.4	1.8	2.4	1.4	1.2	1.0	1.5	1.2	1.4	1.4	1.4	1.6	1.2	1.2
Ever had bowel cancer screening	1.4	1.6	2.5	1.2	1.6	1.5	1.4	1.5	0.8	0.4	1.2	1.1	1.5	1.4
Unable to work because of sickness or disability	1.4	1.9	3.3	1.8	1.2	1.7	1.6	1.2	0.8	1.3	0.7	1.4	1.2	1.7
Had other major operations	1.3	1.5	2.0	1.3	1.4	1.1	1.3	1.4	1.1	0.7	1.4	1.3	1.4	1.0
Bipolar Disorder (2018)	1.2	1.8	6.9	-0.4	0.2	-0.9	-1.7	0.2	-2.0	-1.2	-1.1	-2.6	0.2	-1.7
Blood Platelet Count	1.2	14.5	27.7	-4.5	-5.2	-2.5	-3.3	-5.3	-1.1	-4.0	-3.3	-1.1	-5.3	-3.2
Sensitivity / hurt feelings	1.2	2.0	2.7	1.3	1.6	0.9	1.5	1.6	1.3	1.6	1.5	1.1	1.6	1.2
Diabetes (father)	1.2	1.5	2.7	1.0	1.6	1.5	1.1	1.6	0.8	1.0	1.4	0.7	1.6	1.0
Severe depression (siblings)	1.2	1.3	3.6	1.0	1.9	0.1	0.3	1.9	0.2	0.7	1.1	-0.8	1.9	0.4
Relative age voice broke	1.2	1.8	3.0	1.4	1.4	1.7	1.2	1.4	0.2	1.7	1.7	1.0	1.4	1.3
High blood pressure (mother)	1.2	1.7	4.6	-1.4	-1.2	-2.1	-1.4	-1.1	-0.6	-1.0	-0.8	-1.4	-1.1	-1.6
Medication: Cholesterol lowering	1.2	1.9	2.2	1.4	1.5	1.1	1.4	1.5	1.2	1.4	1.3	1.2	1.5	1.5
Length of working week for main job	1.2	1.3	4.5	-0.3	-0.5	-1.1	-1.2	-0.6	-2.1	-0.5	-1.0	-1.7	-0.6	-1.4
Qualifications: O levels/GCSEs or equivalent	1.2	1.9	5.6	-0.8	-0.9	-1.2	-1.5	-0.9	-2.4	-0.9	-1.1	-1.8	-0.9	-1.8
Osteoarthritis (self-reported)	1.2	1.5	2.3	1.0	1.1	1.3	1.4	1.1	1.3	1.3	1.2	1.4	1.1	1.5
Ever had prostate specific antigen (PSA) test	1.2	1.3	2.1	0.5	1.0	1.1	1.3	1.0	1.4	1.4	1.1	1.3	1.0	1.2
Age when periods started (menarche)	1.1	2.6	5.5	1.3	1.0	1.5	1.9	1.1	1.8	1.7	1.6	2.4	1.1	1.7
Hayfever/allergic rhinitis (self-reported)	1.1	1.4	3.1	-1.1	-1.2	-1.8	-1.1	-1.2	-0.2	-1.2	-1.4	-0.8	-1.2	-1.4
Heart disease (mother)	1.1	1.4	6.2	-0.3	-0.6	-0.2	-1.4	-0.6	-2.5	-0.1	-1.0	-1.9	-0.6	-1.0
Family relationship satisfaction	1.1	1.3	2.4	0.8	0.9	0.7	1.4	0.9	1.6	1.2	1.1	1.5	0.9	1.4
Medication: Aspirin	1.1	1.4	2.5	1.6	1.2	1.2	1.3	1.2	0.2	1.3	0.9	1.1	1.2	1.4
Depression (Nagel 2018)	1.0	1.6	2.9	-1.7	-0.9	-1.6	-1.2	-1.0	0.7	-1.5	-1.5	-1.3	-1.0	-0.8
Mean Putamen Volume	1.0	1.2	2.5	-1.0	-0.9	-1.2	-1.3	-0.9	-0.6	-0.9	-1.4	-1.6	-0.9	-0.9
Medication: Aspirin	1.0	1.3	2.1	1.5	1.1	1.2	1.3	1.1	0.2	1.3	0.8	1.1	1.1	1.4
Medication: Gliclazide	1.0	1.2	2.5	1.6	0.9	1.4	0.8	0.9	-1.3	1.6	0.4	0.2	0.9	0.8
Medication: Lisinopril	1.0	1.3	2.5	1.5	0.9	0.5	1.5	1.0	0.6	1.6	1.0	1.3	1.0	1.4
Alzheimer’s Disease (in mother)	0.9	1.0	1.7	1.3	1.3	0.9	1.1	1.3	0.4	0.7	0.9	0.6	1.3	1.0
Fasting Glucose	0.9	1.1	3.0	-1.4	-0.9	-1.7	-0.8	-1.0	-0.1	-0.7	-0.9	-0.6	-1.0	-1.4
Triglycerides	0.9	1.4	2.5	-1.2	-1.2	-1.0	-1.0	-1.2	-0.6	-1.5	-1.6	-0.8	-1.2	-1.5
Hayfever, allergic rhinitis or eczema	0.9	1.9	5.5	-0.6	-1.0	-0.9	-1.5	-1.0	-2.4	-0.5	-1.3	-2.0	-1.0	-1.8
Shortness of breath walking on level ground	0.9	1.1	2.7	1.4	1.2	1.6	1.0	1.1	0.1	0.5	0.9	1.0	1.1	0.6
Knee pain experienced in last month	0.9	1.4	2.9	-0.9	-1.0	-1.7	-1.4	-1.0	-0.3	-1.4	-1.2	-1.6	-1.0	-1.1
Myopia	0.9	1.2	3.4	-1.2	-0.1	-1.1	-1.4	-0.2	-0.9	-1.3	-0.6	-1.8	-0.2	-1.6
Verbal and Numeric Reasoning (VNR)	0.8	1.9	8.9	-0.4	-1.0	-0.7	-1.0	-1.0	-3.0	-0.6	-1.9	-1.5	-1.0	-1.2
LDL Cholesterol	0.8	1.2	2.2	0.6	1.1	1.1	1.3	1.0	1.4	0.7	1.1	1.5	1.0	1.1
Ulcerative Colitis	0.8	1.2	2.4	-1.2	-0.7	-1.3	-1.5	-0.7	-1.0	-0.9	-0.5	-1.5	-0.7	-1.5
Trunk fat percentage	0.8	3.1	8.3	-0.8	-1.3	-1.2	-2.0	-1.3	-2.9	-1.4	-1.9	-2.6	-1.3	-1.5
Average weekly fortified wine intake	0.8	0.9	1.5	0.8	1.0	0.9	1.2	1.1	0.2	0.8	1.1	1.1	1.1	0.5
Maternal smoking around birth	0.8	1.2	3.9	0.6	0.4	0.6	1.3	0.4	1.6	0.7	1.3	2.0	0.4	1.3
Past tobacco smoking	0.8	1.5	2.6	-1.1	-1.6	-1.0	-0.9	-1.5	-1.2	-1.0	-0.9	-0.3	-1.5	-1.5
Illnesses of siblings	0.8	1.1	2.0	-0.9	-0.7	-1.1	-1.1	-0.7	-0.8	-1.3	-1.1	-1.3	-0.7	-1.4
Neuroticism score	0.8	1.7	3.0	1.2	1.7	0.6	1.5	1.7	1.2	0.7	1.4	1.1	1.7	0.7
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	3.4	-0.3	-0.7	-1.2	-1.2	-0.7	-1.8	-0.5	-1.5	-1.7	-0.7	-1.0
Prospective memory result	0.8	1.0	2.9	0.6	0.8	1.1	1.0	0.8	1.2	0.6	1.7	1.5	0.8	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.5	3.6	-1.8	-1.9	-1.8	-1.5	-1.9	-0.2	-1.4	-1.7	-1.1	-1.9	-1.3
Hypothyroidism/myxoedema (self-reported)	0.8	1.5	3.6	-0.8	-1.9	-0.1	-0.8	-1.8	-1.9	-0.8	-0.8	-0.4	-1.8	-0.6
Back pain experienced in last month	0.8	1.1	2.2	1.0	1.0	0.4	1.1	1.1	1.2	1.1	1.1	0.8	1.1	1.5
Smoking status: Current	0.8	1.2	2.8	-1.3	-1.1	-1.0	-1.0	-1.1	0.2	-1.4	-1.7	-0.8	-1.1	-0.5
Wears glasses or contact lenses	0.8	0.9	1.5	1.1	1.2	0.7	1.1	1.2	0.2	0.1	1.1	0.9	1.2	0.6
Financial situation satisfaction	0.8	1.0	3.0	0.7	0.4	1.0	1.4	0.4	1.1	1.2	0.5	1.7	0.4	1.4
Pain type(s) experienced in last month: Hip pain	0.8	1.0	2.1	-1.0	-1.3	-1.5	-0.9	-1.2	-0.4	-0.7	-0.7	-0.7	-1.2	-0.7
Medication: Atorvastatin	0.8	1.0	1.8	1.3	1.1	0.6	1.1	1.1	0.7	1.1	0.7	0.7	1.1	1.3
Supplements: Calcium	0.8	0.9	1.3	-0.8	-0.8	-1.1	-0.9	-0.8	-0.7	-0.8	-1.0	-1.0	-0.8	-1.2
Lupus	0.7	1.0	1.8	-1.2	-0.9	-0.4	-1.0	-0.9	-1.0	-1.1	-1.0	-1.0	-0.9	-1.3
Number of treatments/medications taken	0.7	1.3	4.1	-0.8	-0.9	-1.0	-1.3	-0.9	-2.0	-0.7	-0.6	-1.6	-0.9	-1.1
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	2.0	0.9	0.8	1.0	0.8	0.8	0.6	1.0	1.4	1.0	0.8	0.5
Qualifications: None of the above	0.7	1.5	2.4	1.5	1.2	1.4	1.2	1.2	1.0	1.1	0.8	1.1	1.2	1.5
Arm fat percentage (right)	0.7	2.9	5.8	-0.9	-1.5	-1.3	-1.9	-1.5	-2.4	-1.4	-2.0	-2.4	-1.5	-1.3
Ever highly irritable/argumentative for 2 days	0.7	0.8	1.7	0.9	0.8	1.3	1.0	0.9	0.0	1.0	1.0	0.9	0.9	0.7
Headache pain in last month	0.7	1.3	4.1	-0.4	-0.2	-1.1	-1.2	-0.2	-2.0	-1.3	-0.5	-1.7	-0.2	-1.6
Chronic bronchitis/emphysema (mother)	0.7	0.8	1.8	0.7	1.1	0.1	0.8	1.1	1.1	0.3	1.3	0.8	1.1	0.4
Body fat percentage	0.7	2.8	5.1	-0.9	-1.5	-1.4	-1.9	-1.5	-2.2	-1.4	-2.0	-2.3	-1.5	-1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.8	3.7	-0.0	0.2	0.5	1.2	0.2	1.6	0.2	1.0	1.9	0.2	0.5
Supplements: Vitamin C	0.7	0.9	1.8	0.7	1.0	0.4	0.9	0.9	1.3	1.2	0.8	0.8	0.9	1.0
Arm fat percentage (left)	0.7	2.7	6.2	-0.7	-1.3	-1.3	-1.8	-1.3	-2.5	-1.2	-1.9	-2.4	-1.3	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	2.0	-0.3	-0.7	-1.4	-0.8	-0.6	-1.0	-0.7	-1.2	-1.2	-0.6	-0.5
Illnesses of father: None of the above (group 1)	0.7	0.9	1.4	-0.6	-0.9	-0.6	-1.1	-0.9	-1.2	-0.8	-1.1	-1.1	-0.9	-0.9
Guilty feelings	0.7	1.0	1.5	1.1	1.2	0.5	1.2	1.2	0.7	0.8	1.0	1.0	1.2	0.9
Mother’s age at death	0.7	0.9	1.4	0.7	1.0	0.3	1.1	1.1	1.2	1.0	0.7	1.0	1.1	1.0
Ever smoked	0.7	1.2	2.3	0.8	1.5	1.1	0.6	1.5	1.2	0.8	0.9	0.1	1.5	1.3
Risk taking	0.7	1.0	4.4	-0.8	-0.4	-2.1	-0.9	-0.5	0.2	-1.3	-1.0	-1.1	-0.5	-0.9
Neuroticism	0.6	1.4	2.4	1.2	1.6	0.8	1.4	1.5	1.0	0.8	1.0	1.1	1.5	1.0
Ever used hormone-replacement therapy (HRT)	0.6	0.7	2.4	-0.2	-0.9	-0.4	-0.7	-0.9	-1.5	-1.0	-0.7	-0.7	-0.9	-0.6
Angina	0.6	0.7	2.4	-0.1	-0.4	-0.4	-1.1	-0.4	-1.5	-0.9	-0.6	-1.4	-0.4	-0.9
Medication: Co-codamol	0.6	0.7	2.1	-0.9	-0.4	-0.9	-1.1	-0.4	-0.6	-0.7	-0.6	-1.4	-0.4	-1.0
Diabetes (mother)	0.6	0.8	1.3	-0.9	-0.8	-1.1	-1.0	-0.8	-0.3	-0.8	-0.9	-1.1	-0.8	-0.7
Townsend deprivation index at recruitment	0.6	0.8	2.1	-0.7	-1.1	-0.5	-0.5	-1.1	-1.0	-0.6	-1.5	-0.5	-1.1	-0.7
Trunk fat mass	0.6	2.4	5.2	-0.8	-1.3	-1.3	-1.8	-1.3	-2.2	-1.3	-1.8	-2.3	-1.3	-1.2
Hair/balding pattern: Pattern 3	0.6	0.8	1.9	-1.2	-0.8	-1.4	-0.8	-0.8	0.6	-1.3	-0.7	-0.6	-0.8	-0.7
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	1.7	-1.3	-1.1	-1.0	-1.0	-1.1	-0.2	-1.3	-0.8	-0.6	-1.1	-1.2
Number of children fathered	0.6	0.7	1.3	-0.7	-0.6	-0.9	-1.0	-0.7	-0.9	-0.8	-0.6	-1.1	-0.7	-1.2
Medication: Blood pressure	0.6	1.1	2.2	1.5	1.1	1.0	1.0	1.1	-0.3	1.3	0.5	0.6	1.1	1.3
Angina (self-reported)	0.6	0.7	2.8	-0.0	-0.3	-0.3	-1.1	-0.3	-1.7	-0.8	-0.6	-1.4	-0.3	-0.9
Medication: Allopurinol	0.6	0.7	3.2	-0.5	-0.5	-0.2	-0.9	-0.5	-1.8	-0.5	-0.3	-1.1	-0.5	-1.2
Comparative height size at age 10	0.6	3.5	6.7	-1.4	-1.4	-1.8	-2.1	-1.4	-2.3	-1.7	-1.8	-2.6	-1.4	-2.2
Smoking status: Previous	0.6	0.9	2.0	1.0	1.4	0.7	0.5	1.4	0.4	0.9	0.9	-0.1	1.4	1.0
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.2	-0.7	-1.1	-0.5	-0.8	-1.1	-0.8	-0.8	-1.0	-0.6	-1.1	-0.4
Long-standing illness, disability or infirmity	0.6	1.0	2.8	-0.4	-0.7	-0.8	-0.9	-0.7	-1.7	-0.8	-1.2	-1.3	-0.7	-0.9
Commuting to job workplace: Walk	0.6	0.7	2.6	-0.1	1.1	-0.8	0.3	1.1	1.6	-0.2	0.6	-0.1	1.1	-0.0
Bipolar Disorder or Schizophrenia	0.5	1.2	4.4	-0.4	0.4	-0.9	-1.3	0.3	-1.4	-1.1	-0.7	-2.1	0.3	-1.5
Lung FVC	0.5	2.4	4.8	-1.1	-2.2	-0.7	-1.4	-2.1	-1.5	-1.2	-1.9	-1.1	-2.1	-0.9
Qualifications: CSEs or equivalent	0.5	0.6	1.2	-0.4	-1.1	-0.2	-0.8	-1.1	-0.8	-0.3	-0.9	-0.7	-1.1	-0.4
Impedance of arm (right)	0.5	2.4	5.8	-1.5	-1.1	-0.5	-1.6	-1.1	-2.4	-1.6	-1.0	-1.6	-1.1	-2.3
Arm fat mass (right)	0.5	2.1	4.0	-0.8	-1.4	-1.3	-1.6	-1.4	-1.8	-1.2	-1.8	-2.0	-1.4	-1.0
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.5	-0.5	-0.8	-0.6	-0.6	-0.8	-0.8	-0.9	-1.2	-0.6	-0.8	-0.6
Medication: Omeprazole	0.5	0.6	1.4	1.0	0.6	1.2	0.9	0.6	0.0	0.8	0.4	0.8	0.6	1.1
Whole body fat mass	0.5	1.9	3.2	-0.8	-1.4	-1.3	-1.5	-1.4	-1.5	-1.2	-1.6	-1.8	-1.4	-0.9
Chest pain or discomfort	0.5	0.7	1.5	0.8	1.2	0.9	0.4	1.2	0.3	0.6	0.7	-0.1	1.2	0.7
Illnesses of siblings: Diabetes	0.5	0.6	1.1	0.8	0.5	0.7	0.7	0.5	0.8	1.1	1.0	0.9	0.5	0.9
Average weekly red wine intake	0.5	0.8	1.2	1.1	1.0	0.9	0.9	1.0	0.2	0.9	1.1	0.8	1.0	0.8
Mineral and other dietary supplements	0.5	0.7	2.6	0.8	-0.1	1.4	0.9	-0.1	0.4	0.4	0.6	1.6	-0.1	0.9
Commuting to job workplace: Public transport	0.5	0.6	2.4	-0.1	0.1	-1.0	-1.0	0.0	-1.2	-0.0	-0.2	-1.6	0.0	-1.0
Neuroticism (Nagel 2018)	0.4	1.0	3.3	0.5	1.2	0.1	1.0	1.1	1.8	0.1	1.0	0.9	1.1	0.6
Alzheimer’s Disease (in father)	0.4	0.4	0.8	0.3	0.9	-0.3	0.7	0.7	0.8	-0.0	0.9	0.6	0.7	0.1
Age at First Birth	0.4	0.7	1.7	-0.6	-0.3	-0.7	-1.2	-0.3	-0.8	-0.9	-0.3	-1.3	-0.3	-1.2
Bipolar Disorder (2011)	0.4	0.4	1.5	-0.1	-0.2	-0.1	-0.8	-0.3	-1.2	-0.6	-0.8	-1.0	-0.3	-0.7
Respiratory disease	0.4	0.9	1.4	1.2	1.1	0.6	1.0	1.0	0.6	1.0	1.1	0.9	1.0	0.7
Frequency of depressed mood in last 2 weeks	0.4	0.6	2.0	-1.2	-0.3	-1.4	-0.4	-0.3	1.2	-0.4	-0.7	-0.4	-0.3	-0.5
Ever had hysterectomy (womb removed)	0.4	0.4	1.6	-0.2	-0.7	-0.1	-0.5	-0.7	-1.2	-0.5	-0.6	-0.3	-0.7	-0.7
Waist circumference	0.4	1.6	3.2	-0.7	-1.2	-0.9	-1.3	-1.2	-1.8	-1.1	-1.5	-1.6	-1.2	-0.9
Nervous feelings	0.4	0.7	1.6	0.5	0.9	0.5	1.0	0.9	1.3	-0.2	0.9	1.1	0.9	0.3
Ever unenthusiastic/disinterested for a whole week	0.4	0.4	1.3	0.7	0.2	0.8	0.9	0.3	0.1	0.8	0.2	1.1	0.3	0.8
Forced expiratory volume in 1-second (FEV1)	0.4	1.2	1.9	-1.0	-1.3	-1.0	-1.1	-1.2	-0.8	-0.8	-1.4	-1.1	-1.2	-0.9
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.2	-0.7	-1.1	-0.7	-0.0	-1.1	0.7	-0.1	-0.2	0.6	-1.1	0.2
Lung cancer (father)	0.4	0.5	4.0	0.6	-0.1	0.3	-0.2	-0.1	-2.0	-0.0	-0.5	-0.7	-0.1	-0.2
Illnesses of mother	0.4	0.4	1.0	-0.3	-0.9	0.5	0.3	-0.9	0.4	-0.1	-0.8	1.0	-0.9	0.2
Pulse wave Arterial Stiffness index	0.4	0.5	2.7	-0.3	-0.4	0.5	-0.5	-0.4	-1.6	-0.6	-0.9	-0.8	-0.4	-0.5
Impedance of arm (left)	0.4	1.8	6.9	-1.1	-0.7	-0.1	-1.4	-0.7	-2.6	-1.2	-0.8	-1.6	-0.7	-2.0
Neck or shoulder pain in last month	0.4	0.6	1.7	0.7	0.8	0.3	0.6	0.8	1.3	0.5	0.4	0.4	0.8	1.1
Breast cancer (self-reported)	0.4	0.5	1.0	0.4	0.9	0.4	0.7	0.8	1.0	0.1	0.7	0.8	0.8	0.5
Osteoporosis (self-reported)	0.4	0.5	2.2	1.0	0.5	0.2	0.2	0.5	-1.5	1.0	-0.5	-0.6	0.5	0.6
Arm fat mass (left)	0.4	1.7	3.5	-0.6	-1.1	-1.2	-1.4	-1.2	-1.7	-1.1	-1.6	-1.9	-1.2	-0.8
Basal cell carcinoma (self-reported)	0.4	0.4	1.3	-0.9	-0.2	-0.6	-0.7	-0.3	0.5	-1.2	-0.3	-0.5	-0.3	-0.9
Heart disease (siblings)	0.4	0.5	1.1	-0.8	-1.0	0.1	-0.1	-1.0	0.2	-0.8	-0.8	0.4	-1.0	0.1
HDL Cholesterol	0.3	0.5	2.1	0.3	0.2	-0.2	0.7	0.1	1.4	0.6	0.3	0.9	0.1	1.1
Primary Biliary Cirrhosis	0.3	0.4	1.0	-0.8	0.1	-0.7	-0.6	0.1	-0.3	-1.0	0.0	-0.9	0.1	-0.9
Schizophrenia (2014)	0.3	0.8	2.2	-0.4	-0.3	-0.8	-1.1	-0.3	-1.2	-0.6	-0.9	-1.5	-0.3	-1.2
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.9	-0.8	-0.3	-0.7	-0.5	-0.3	0.1	-1.0	-0.1	-0.2	-0.3	-0.9
Hypothyroidism (self reported)	0.3	0.7	1.8	-0.3	-1.4	0.3	-0.2	-1.3	-1.3	-0.3	-0.4	0.1	-1.3	-0.1
Hearing difficulty/problems: Yes	0.3	0.5	2.5	0.3	0.1	0.3	-0.7	0.2	-1.6	-0.4	-0.1	-1.2	0.2	-0.7
Hand grip strength (right)	0.3	0.9	2.2	0.3	0.9	0.8	0.8	0.9	1.5	0.6	1.4	1.0	0.9	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.1	0.8	0.4	0.4	0.8	0.4	0.4	0.9	0.2	0.6	0.4	1.1
Taking other prescription medications	0.3	0.5	2.2	-0.3	-0.4	-0.1	-0.8	-0.4	-1.5	-0.4	-0.3	-1.1	-0.4	-0.5
Stomach or abdominal pain in last month	0.3	0.3	1.0	0.5	1.0	-0.4	0.1	0.9	0.1	-0.1	0.5	-0.3	0.9	-0.4
Alcohol usually taken with meals	0.3	0.4	0.9	0.7	0.9	0.7	0.2	1.0	-0.4	0.4	0.8	-0.0	1.0	-0.1
Forced vital capacity (FVC)	0.3	1.1	1.9	-0.9	-1.4	-0.8	-1.0	-1.3	-0.9	-0.8	-1.2	-0.8	-1.3	-0.8
Financial difficulties in last 2 years	0.3	0.5	1.3	-0.6	-0.6	-1.0	-0.6	-0.6	-0.5	-0.3	-1.1	-0.8	-0.6	-0.5
Allergy	0.3	0.6	2.0	0.2	0.5	0.5	0.8	0.6	1.4	0.2	0.7	1.1	0.6	1.1
Fluid intelligence score	0.3	0.6	3.5	-0.1	-0.3	-0.7	-0.6	-0.3	-1.9	-0.3	-0.5	-0.8	-0.3	-1.1
Weight	0.3	1.6	2.9	-0.8	-1.2	-1.4	-1.4	-1.3	-1.3	-1.0	-1.5	-1.7	-1.3	-0.8
Hip circumference	0.3	1.5	4.6	-0.2	-1.2	-0.7	-1.1	-1.2	-2.1	-0.4	-1.7	-1.5	-1.2	-0.5
Alcohol intake versus 10 years previously	0.3	0.4	1.1	-0.5	-0.4	-1.0	-0.3	-0.4	0.8	-1.1	-0.4	-0.2	-0.4	-0.4
Father’s age at death	0.3	0.4	2.5	-0.9	-0.0	-0.5	-0.1	-0.0	1.6	-0.5	0.4	0.5	-0.0	-0.6
Noisy workplace	0.3	0.3	0.8	-0.4	-0.9	-0.6	-0.1	-0.8	-0.1	-0.3	-0.8	0.2	-0.8	-0.1
Qualifications: A levels/AS levels or equivalent	0.3	0.7	2.5	-0.3	0.1	-0.8	-0.9	0.1	-1.6	0.1	-0.2	-1.5	0.1	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.2	0.6	0.5	1.1	0.9	0.5	-0.5	0.4	1.0	1.0	0.5	0.0
Gout (self-reported)	0.3	0.4	1.5	0.4	0.3	1.2	0.4	0.3	-0.8	0.9	0.8	0.4	0.3	0.0
Medication: Amlodipine	0.3	0.4	1.2	0.9	0.6	1.1	0.4	0.6	-0.6	0.5	-0.1	-0.0	0.6	0.6
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.5	-0.1	-0.4	0.0	-0.8	-0.4	-1.2	-0.6	-0.7	-1.1	-0.4	-0.5
Forced vital capacity (FVC), Best measure	0.3	1.3	2.2	-1.4	-1.5	-1.3	-1.0	-1.5	0.3	-0.9	-1.0	-0.5	-1.5	-0.8
Leg fat percentage (right)	0.3	1.0	1.6	-0.6	-1.1	-1.1	-1.0	-1.1	-0.6	-1.0	-1.3	-1.0	-1.1	-0.4
Exposure to tobacco smoke outside home	0.3	0.4	1.1	1.1	0.5	0.9	0.5	0.5	-0.4	0.8	0.3	0.2	0.5	0.9
Wheeze or whistling in the chest in last year	0.3	0.5	1.0	1.0	0.8	0.9	0.7	0.8	-0.1	0.9	0.7	0.5	0.8	0.4
Pulse wave peak to peak time	0.3	0.3	1.9	0.2	0.1	-0.5	0.4	0.1	1.4	0.4	0.6	0.7	0.1	0.3
Eye problems/disorders: None of the above	0.3	0.3	1.2	-0.7	-0.0	-1.1	-0.7	-0.1	0.2	-0.3	0.0	-1.1	-0.1	-0.2
Migraine (self-reported)	0.3	0.4	0.5	-0.6	-0.7	-0.7	-0.7	-0.7	-0.7	-0.3	-0.4	-0.6	-0.7	-0.5
Leg fat mass (right)	0.3	1.2	1.7	-0.8	-1.2	-1.3	-1.1	-1.3	-0.4	-1.0	-1.3	-1.1	-1.3	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.8	-0.4	-0.4	-0.2	-0.7	-0.4	-0.8	-0.3	-0.6	-0.9	-0.4	-0.6
Illnesses of father: Heart disease	0.3	0.4	0.8	0.0	0.9	-0.7	0.2	0.8	0.8	-0.1	0.9	-0.0	0.8	-0.4
Mood swings	0.3	0.5	1.4	-0.3	0.3	-1.2	-0.5	0.4	-0.3	-0.9	-0.2	-1.1	0.4	-0.9
Diabetes diagnosed by doctor	0.3	0.5	1.5	-0.3	-0.7	-0.8	-0.7	-0.7	-0.8	-0.4	-1.2	-0.9	-0.7	-0.4
Eye problems/disorders: Cataract	0.3	0.3	0.6	-0.5	-0.7	0.6	-0.2	-0.7	-0.5	-0.6	-0.7	0.3	-0.7	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	1.1	0.5	0.3	1.1	0.6	0.3	0.2	0.6	0.3	0.7	0.3	0.7
Ever taken oral contraceptive pill	0.3	0.3	0.8	-0.9	-0.1	-0.7	-0.7	-0.2	0.3	-0.8	0.2	-0.7	-0.2	-0.8
Medication: Blood pressure	0.3	0.6	1.0	-0.4	-0.8	-0.5	-0.6	-0.8	-1.0	-0.9	-0.9	-0.4	-0.8	-0.9
High cholesterol (Self-reported)	0.3	0.6	1.0	0.8	0.5	0.7	0.8	0.5	0.8	0.9	0.7	1.0	0.5	0.9
Leg fat percentage (left)	0.3	1.1	1.7	-0.7	-1.2	-1.2	-1.1	-1.1	-0.7	-1.1	-1.3	-1.2	-1.1	-0.5
Average weekly beer plus cider intake	0.3	0.4	1.2	0.6	0.3	1.1	0.6	0.3	0.3	0.9	0.3	0.7	0.3	0.8
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	2.9	-0.5	-0.1	-0.2	0.3	-0.1	1.7	-0.4	0.2	0.7	-0.1	0.5
Leg fat mass (left)	0.3	1.4	2.1	-0.9	-1.3	-1.4	-1.2	-1.3	-0.5	-1.1	-1.4	-1.3	-1.3	-0.6
Worry (Nagel 2018)	0.2	0.5	2.7	-0.3	0.3	-0.1	0.5	0.2	1.6	-1.0	0.1	0.8	0.2	0.0
Allergy or Eczema	0.2	0.5	3.2	0.6	-0.1	0.1	-0.4	-0.1	-1.8	0.8	-0.2	-0.9	-0.1	-0.4
Cardiovascular Disease	0.2	0.7	1.4	0.6	0.8	0.8	1.1	0.8	1.0	0.3	0.6	1.2	0.8	0.9
Relative age of first facial hair	0.2	0.4	2.2	0.2	0.3	0.6	-0.3	0.3	-1.5	0.1	0.8	-0.6	0.3	-0.5
Vitamin and mineral supplements	0.2	0.2	0.5	-0.5	-0.5	-0.3	-0.2	-0.5	0.0	-0.7	0.2	0.2	-0.5	-0.7
Supplements: Zinc	0.2	0.3	1.8	-0.2	0.1	0.1	0.4	0.1	1.3	0.3	0.3	0.7	0.1	0.5
Leg fat-free mass (left)	0.2	0.9	2.1	-0.5	-0.8	-1.1	-1.1	-0.8	-1.2	-0.5	-0.9	-1.5	-0.8	-0.7
Fed-up feelings	0.2	0.3	1.0	0.0	-0.1	-1.0	-0.4	-0.1	-0.8	-0.6	-0.7	-0.8	-0.1	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.5	0.2	0.3	-0.2	0.7	0.3	1.2	0.2	0.7	0.9	0.3	0.7
Serious illness, injury or assault to yourself	0.2	0.2	0.7	-0.1	0.5	-0.6	-0.4	0.4	-0.2	-0.3	0.1	-0.8	0.4	-0.5
Supplements: Glucosamine	0.2	0.2	0.6	-0.7	-0.3	-0.6	-0.6	-0.3	-0.1	0.1	-0.5	-0.8	-0.3	-0.0
Medication: Atenolol	0.2	0.2	0.8	-0.0	0.5	-0.8	-0.3	0.5	-0.1	-0.3	0.3	-0.9	0.5	-0.4
Medication: Levothyroxine sodium	0.2	0.4	1.0	0.1	-0.9	1.0	0.2	-0.8	-0.9	0.3	0.3	0.5	-0.8	0.3
Body mass index (BMI)	0.2	0.8	1.6	-0.3	-0.8	-1.1	-1.0	-0.8	-0.9	-0.7	-1.1	-1.3	-0.8	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.4	1.6	-0.4	0.3	-1.3	0.1	0.3	1.2	-0.6	0.3	0.1	0.3	-0.4
Time employed in main current job	0.2	0.2	1.4	-0.1	0.3	-0.4	-0.0	0.3	1.2	0.5	-0.0	-0.2	0.3	0.4
Worrier / anxious feelings	0.2	0.4	0.7	0.5	0.7	0.4	0.9	0.7	0.8	0.4	0.7	0.8	0.7	0.4
Pulse rate	0.2	0.3	1.0	-0.3	-0.1	-0.4	-0.6	-0.1	-0.4	-1.0	-0.6	-0.7	-0.1	-0.9
Asthma	0.2	0.4	0.7	0.8	0.7	0.6	0.6	0.6	0.2	0.7	0.7	0.6	0.6	0.2
Standing height	0.2	1.8	2.5	-1.6	-1.3	-1.3	-1.4	-1.3	-1.1	-1.3	-1.1	-1.4	-1.3	-1.6
Tense / ‘highly strung’	0.2	0.3	1.7	0.1	0.2	0.1	0.7	0.3	1.3	-0.7	0.0	0.8	0.3	0.6
Hair/balding pattern: Pattern 4	0.2	0.6	1.5	-0.4	-1.2	0.2	-0.4	-1.2	-0.7	0.1	-0.8	-0.0	-1.2	-0.0
Blood clot in the leg (DVT)	0.2	0.3	2.1	-0.5	-0.1	-0.2	0.2	-0.2	1.5	-0.5	0.1	0.6	-0.2	0.4
Glaucoma (self-reported)	0.2	0.3	0.6	0.4	0.3	0.3	0.7	0.4	0.3	0.7	0.5	0.8	0.4	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.7	0.6	0.5	-0.1	0.5	0.5	0.9	0.3	0.3	0.6	0.5	0.3
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.5	-0.5	-0.7	-0.3	-0.2	-0.7	0.1	-0.5	-0.7	0.1	-0.7	-0.0
Medication for pain relief, constipation, heartburn	0.2	0.4	1.1	-0.7	-0.1	-0.5	-0.9	-0.2	-0.5	-0.3	-0.5	-1.1	-0.2	-1.1
Medication: Ibuprofen	0.2	0.3	0.6	-0.3	-0.8	-0.4	0.2	-0.7	0.5	0.2	-0.2	0.6	-0.7	0.3
Had major operations	0.2	0.2	0.7	-0.5	0.1	-0.4	-0.5	0.0	-0.3	-0.4	-0.5	-0.7	0.0	-0.8
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.6	-0.8	-0.7	-0.1	-0.2	-0.7	0.6	-0.6	0.1	0.4	-0.7	-0.1
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	1.1	0.1	-0.4	-0.0	0.4	-0.2	0.9	-0.2	0.3	1.1	-0.2	0.4
Leg fat-free mass (right)	0.2	1.3	2.9	-0.7	-1.0	-1.3	-1.3	-1.0	-1.5	-0.7	-1.1	-1.7	-1.0	-0.9
Loneliness, isolation	0.2	0.2	0.9	-0.2	-0.1	-0.9	0.4	-0.1	1.0	-0.1	0.3	0.5	-0.1	0.2
Leg predicted mass (right)	0.2	1.2	2.8	-0.7	-0.9	-1.3	-1.3	-1.0	-1.5	-0.7	-1.0	-1.7	-1.0	-0.9
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.9	-0.5	0.2	-1.0	-0.5	0.2	-0.0	-0.3	0.0	-0.9	0.2	-0.7
Basal metabolic rate	0.2	1.1	1.9	-0.7	-1.1	-1.2	-1.1	-1.1	-1.0	-0.7	-1.2	-1.4	-1.1	-0.6
Irritability	0.2	0.3	1.9	-0.0	0.4	-0.7	0.5	0.4	1.4	0.3	-0.2	0.3	0.4	0.7
Age started oral contraceptive pill	0.2	0.2	0.6	0.6	0.4	0.3	0.6	0.4	0.4	0.4	0.3	0.6	0.4	0.8
Ever depressed for a whole week	0.2	0.2	0.7	0.5	0.2	-0.0	0.8	0.3	-0.3	0.6	0.0	0.8	0.3	0.3
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.6	0.7	0.6	0.5	0.5	0.6	-0.0	0.4	0.0	0.1	0.6	0.8
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.7	0.4	0.7	0.2	0.2	0.8	0.1	-0.4	0.8	0.0	0.8	-0.1
Impedance of whole body	0.2	1.0	2.6	-1.0	-0.7	-0.1	-1.0	-0.7	-1.5	-1.1	-0.6	-0.8	-0.7	-1.6
Depressed Affect (Nagel 2018)	0.1	0.3	0.7	0.1	0.8	-0.4	0.3	0.8	0.8	-0.3	0.5	0.0	0.8	-0.1
Intelligence (Savage-Jansen 2018)	0.1	0.3	1.7	-0.1	-0.3	-0.6	-0.3	-0.3	-1.3	-0.0	-0.6	-0.5	-0.3	-0.8
Schizophrenia (2018)	0.1	0.1	0.3	-0.1	0.3	-0.4	-0.3	0.3	-0.2	-0.4	-0.0	-0.6	0.3	-0.5
Schizophrenia vs Biploar Disorder	0.1	0.2	0.6	0.1	-0.1	0.5	0.4	-0.1	0.7	0.3	0.1	0.7	-0.1	0.3
Reaction Time	0.1	0.2	0.9	-0.4	-0.2	-0.9	-0.3	-0.3	0.2	-0.5	-0.0	-0.2	-0.3	-0.9
Ovarian Cancer	0.1	0.1	0.2	-0.1	-0.3	-0.4	0.2	-0.3	0.3	-0.1	-0.4	0.2	-0.3	0.1
Body Mass Index (BMI) (2010)	0.1	0.1	0.2	0.0	0.4	-0.4	-0.1	0.4	0.3	0.1	0.2	-0.3	0.4	-0.2
Neuroticism (2016)	0.1	0.2	0.9	-0.2	-0.4	-0.3	0.1	-0.4	0.9	0.3	0.0	0.4	-0.4	0.1
Blood Red Count	0.1	0.7	1.3	1.0	0.6	0.5	1.0	0.6	0.9	0.8	0.7	1.2	0.6	1.0
Waist Hip Ratio (WHR)	0.1	0.4	2.4	-0.8	-0.2	-0.2	-0.2	-0.2	0.4	-1.5	-0.1	0.1	-0.2	-0.8
Smoking Status	0.1	0.2	0.9	-0.1	0.1	-0.1	-0.4	0.0	-0.4	-0.2	-0.8	-0.9	0.0	0.0
Lung FEV1/FVC ratio	0.1	0.6	1.5	0.7	1.2	0.6	0.4	1.1	-0.0	0.8	0.5	-0.1	1.1	0.2
Tanning	0.1	1.3	3.2	1.0	1.0	0.4	1.3	1.0	1.6	1.0	0.5	1.0	1.0	1.8
Hand grip strength (left)	0.1	0.3	1.0	-0.2	0.1	0.5	0.3	0.1	1.0	0.1	1.0	0.8	0.1	0.4
Average weekly spirits intake	0.1	0.2	0.6	0.3	0.4	0.5	-0.0	0.3	-0.6	0.1	0.8	-0.3	0.3	0.2
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.4	0.6	0.5	0.5	0.5	0.5	-0.1	0.2	-0.0	0.2	0.5	0.6
Systolic blood pressure, automated reading	0.1	0.2	0.6	-0.1	-0.7	0.4	-0.1	-0.7	0.1	-0.0	-0.8	0.2	-0.7	0.7
Medication: Metformin	0.1	0.1	0.3	0.0	-0.4	-0.2	-0.4	-0.3	-0.6	0.2	-0.5	-0.5	-0.3	-0.0
Pack years adult smoking proportion	0.1	0.2	0.5	0.4	0.5	-0.6	-0.2	0.5	-0.3	0.1	-0.3	-0.7	0.5	-0.2
Impedance of leg (right)	0.1	0.2	0.6	-0.8	-0.6	0.0	-0.2	-0.5	0.4	-0.6	-0.3	0.3	-0.5	-0.6
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.3	0.3	-0.1	0.3	-0.0	-0.1	-0.5	0.3	0.3	0.1	-0.1	0.2
Impedance of leg (left)	0.1	0.4	1.0	-1.0	-0.8	-0.2	-0.5	-0.8	0.1	-0.9	-0.5	-0.0	-0.8	-0.8
Leg predicted mass (left)	0.1	0.8	1.8	-0.5	-0.8	-1.1	-1.0	-0.8	-1.1	-0.4	-0.9	-1.4	-0.8	-0.6
Number of incorrect matches in round	0.1	0.1	0.4	-0.2	0.4	0.1	-0.2	0.4	0.0	-0.3	0.6	-0.2	0.4	-0.5
Hearing difficulty/problems with background noise	0.1	0.1	0.4	0.3	0.5	0.4	-0.0	0.5	-0.1	0.0	0.6	-0.2	0.5	-0.1
Had menopause	0.1	0.1	0.2	0.5	0.3	-0.2	0.1	0.3	-0.2	-0.2	0.0	-0.2	0.3	0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.6	0.4	0.5	-0.2	0.5	0.5	0.8	0.3	0.6	0.5	0.5	0.6
Heart attack	0.1	0.2	0.4	0.2	0.6	-0.0	-0.0	0.6	0.1	-0.5	0.7	-0.1	0.6	-0.2
Diabetes (self-reported)	0.1	0.1	0.4	0.1	-0.2	-0.2	-0.3	-0.2	-0.6	0.0	-0.5	-0.4	-0.2	0.1
Medication: Simvastatin	0.1	0.1	0.2	0.3	0.3	0.4	0.3	0.2	0.3	0.3	0.2	0.4	0.2	0.3
Trunk fat-free mass	0.1	0.5	0.8	-0.5	-0.9	-0.8	-0.7	-0.9	-0.3	-0.4	-0.9	-0.8	-0.9	-0.1
Falls in the last year	0.1	0.2	0.4	0.6	0.5	-0.2	0.4	0.6	0.4	0.4	-0.1	-0.0	0.6	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.4	-0.2	-0.1	0.6	-0.1	-0.2	-0.7	-0.0	0.1	0.1	-0.2	-0.4
Mouth/teeth dental problems: Dentures	0.1	0.1	0.3	0.1	-0.3	-0.4	-0.2	-0.3	-0.5	-0.1	-0.5	-0.4	-0.3	0.3
Depression (self-reported)	0.1	0.1	0.2	-0.2	-0.4	-0.0	0.0	-0.4	-0.4	-0.0	-0.2	0.1	-0.4	-0.2
Trunk predicted mass	0.1	0.3	0.6	-0.4	-0.7	-0.7	-0.5	-0.8	-0.2	-0.3	-0.8	-0.7	-0.8	-0.1
Breastfed as a baby	0.1	0.1	0.5	0.0	-0.2	-0.1	0.1	-0.2	-0.0	0.7	-0.2	0.1	-0.2	0.2
Peak expiratory flow (PEF)	0.1	0.1	0.6	0.1	0.1	-0.5	-0.3	0.1	-0.5	-0.1	-0.4	-0.7	0.1	-0.4
Pulse wave reflection index	0.1	0.2	0.9	-0.2	-0.0	0.7	-0.1	-0.0	-0.9	-0.1	-0.2	-0.3	-0.0	0.3
Medication: Paracetamol	0.1	0.1	0.3	0.1	-0.1	-0.6	-0.2	-0.1	-0.6	-0.3	-0.2	-0.5	-0.1	-0.1
High blood pressure (siblings)	0.1	0.1	0.5	0.3	0.2	0.1	0.3	0.2	-0.3	0.6	0.7	0.3	0.2	0.2
Comparative body size at age 10	0.1	0.3	0.6	-0.6	-0.8	-0.7	-0.0	-0.8	0.1	0.0	-0.3	0.2	-0.8	0.0
Age at first live birth	0.1	0.2	0.8	0.2	0.2	0.4	0.4	0.2	0.5	0.5	0.9	0.8	0.2	0.3
Qualifications: College or University degree	0.1	0.2	1.1	-0.1	0.3	-0.1	-0.4	0.2	-1.0	0.1	0.3	-0.7	0.2	-0.8
Medication: Seretide 50 evohaler	0.1	0.1	0.2	0.3	-0.2	-0.4	-0.1	-0.1	-0.4	0.1	-0.3	-0.1	-0.1	-0.4
Mean time to correctly identify matches	0.1	0.2	0.4	-0.5	-0.2	-0.7	-0.1	-0.1	0.7	-0.6	-0.0	0.0	-0.1	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.6	0.1	-0.2	0.7	0.0	-0.2	-0.1	0.3	0.1	0.1	-0.2	0.4
Pulse rate, automated reading	0.1	0.2	0.6	0.8	0.6	0.6	0.2	0.6	-0.2	0.3	0.2	0.1	0.6	0.1
Number of full sisters	0.1	0.2	0.4	-0.4	-0.7	-0.0	0.1	-0.7	0.1	-0.2	-0.5	0.3	-0.7	0.1
Age at last live birth	0.1	0.1	0.3	-0.2	-0.6	-0.3	0.1	-0.5	-0.1	0.5	-0.0	0.3	-0.5	0.1
Hypertension (Self-reported)	0.1	0.2	0.6	0.7	0.4	0.8	0.6	0.5	-0.1	0.3	0.1	0.5	0.5	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.1	0.4	-0.4	-0.2	-0.7	-0.3	-0.2	0.0	0.4	0.4	-0.2	-0.2	-0.6
Whole body fat-free mass	0.1	0.6	1.1	-0.5	-0.8	-1.0	-0.8	-0.8	-0.6	-0.5	-0.9	-1.1	-0.8	-0.4
Asthma (self-reported)	0.1	0.2	0.5	0.7	0.6	0.4	0.5	0.5	0.2	0.5	0.5	0.4	0.5	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.5	-0.1	-0.4	-0.3	0.0	-0.4	0.6	-0.0	-0.7	0.2	-0.4	0.3
Whole body water mass	0.1	0.6	1.1	-0.5	-0.8	-1.0	-0.8	-0.8	-0.6	-0.4	-0.9	-1.0	-0.8	-0.3
Number of self-reported non-cancer illnesses	0.1	0.1	0.6	-0.3	0.2	-0.4	-0.3	0.1	0.2	-0.8	0.1	-0.4	0.1	-0.4
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.5	-0.1	0.0	-0.5	0.0	0.1	0.3	-0.7	0.1	0.1	0.1	-0.4
Medication: Bendroflumethiazide	0.1	0.2	0.5	-0.3	-0.6	-0.3	-0.4	-0.6	-0.7	-0.3	-0.2	-0.3	-0.6	-0.3
Medication: Paracetamol	0.1	0.1	0.4	0.2	0.2	-0.6	-0.1	0.2	-0.2	-0.1	0.4	-0.3	0.2	-0.1
Illnesses of father: High blood pressure	0.1	0.1	0.5	-0.1	-0.3	0.1	-0.1	-0.2	-0.7	0.1	-0.4	-0.3	-0.2	-0.3
Alcohol drinker status: Never	0.1	0.1	0.3	-0.1	-0.3	0.4	0.2	-0.3	0.4	0.1	-0.1	0.5	-0.3	0.1
Arm fat-free mass (left)	0.1	0.3	0.6	-0.2	-0.6	-0.8	-0.4	-0.6	-0.0	-0.2	-0.8	-0.6	-0.6	0.1
Number of operations (self-reported)	0.1	0.1	0.2	-0.1	0.5	-0.2	-0.1	0.4	0.5	-0.4	0.1	-0.2	0.4	-0.3
Cholesterol lowering medication	0.1	0.2	0.7	0.2	-0.4	0.3	-0.2	-0.4	-0.8	-0.1	-0.7	-0.2	-0.4	0.2
Pain experienced in last month	0.1	0.2	0.4	-0.6	-0.5	0.1	-0.2	-0.5	-0.3	-0.1	-0.4	0.0	-0.5	-0.6
Pack years of smoking	0.1	0.2	0.5	0.5	0.7	-0.5	0.0	0.7	-0.1	0.3	-0.1	-0.6	0.7	-0.1
Arm predicted mass (left)	0.1	0.3	0.7	-0.1	-0.6	-0.8	-0.4	-0.6	-0.2	-0.2	-0.8	-0.6	-0.6	0.2
Major Depression (MDD)	0.0	0.0	0.1	-0.1	-0.1	-0.3	-0.2	-0.1	0.1	0.2	0.2	-0.2	-0.1	-0.3
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Heel T-Score	0.0	0.1	0.4	-0.3	0.2	-0.5	-0.4	0.1	0.5	-0.6	-0.2	-0.6	0.1	-0.1
BMI	0.0	0.2	0.5	0.5	0.1	-0.6	-0.2	0.0	-0.5	-0.1	-0.7	-0.7	0.0	0.2
Height	0.0	0.6	1.0	-0.9	-1.0	-1.0	-0.7	-0.9	-0.6	-0.8	-0.4	-0.5	-0.9	-0.7
Systolic Blood Pressure	0.0	0.2	0.5	0.3	-0.3	0.6	0.1	-0.3	-0.0	0.4	-0.7	0.2	-0.3	0.6
Type 2 Diabetes (T2D) (2018)	0.0	0.1	0.3	0.3	0.1	0.1	-0.1	0.0	-0.6	-0.3	-0.3	-0.2	0.0	-0.1
Hair Pigment	0.0	0.1	0.2	-0.0	-0.1	-0.2	0.4	-0.1	0.3	0.2	-0.3	0.5	-0.1	0.1
High blood pressure	0.0	0.0	0.2	0.3	-0.1	0.4	0.1	-0.0	-0.4	-0.0	-0.2	0.1	-0.0	0.0
Sitting height	0.0	0.1	0.4	-0.4	-0.4	-0.6	-0.2	-0.4	-0.2	-0.2	-0.5	-0.2	-0.4	-0.3
Mouth/teeth dental problems	0.0	0.0	0.2	-0.4	-0.0	0.0	-0.1	-0.0	0.3	0.1	0.2	0.1	-0.0	-0.4
Birth weight of first child	0.0	0.1	0.3	0.0	0.1	0.3	-0.1	0.1	-0.1	0.5	-0.2	-0.4	0.1	0.3
Arm fat-free mass (right)	0.0	0.1	0.3	0.3	-0.3	-0.5	-0.0	-0.3	0.1	0.2	-0.5	-0.2	-0.3	0.5
Arm predicted mass (right)	0.0	0.2	0.5	0.0	-0.4	-0.7	-0.2	-0.4	0.1	-0.0	-0.6	-0.4	-0.4	0.3
Alcohol intake frequency.	0.0	0.1	0.2	0.1	-0.1	0.4	0.3	-0.1	0.0	-0.3	-0.2	0.5	-0.1	0.1
Overall health rating	0.0	0.0	0.2	0.1	-0.2	0.2	0.1	-0.2	-0.3	0.2	-0.4	0.0	-0.2	0.1
Qualifications: nursing, teaching	0.0	0.0	0.3	-0.0	0.1	0.1	0.1	0.0	-0.5	-0.0	0.4	0.2	0.0	-0.2
Hearing aid user	0.0	0.0	0.2	-0.0	-0.1	-0.3	-0.1	-0.0	0.4	0.1	0.0	0.1	-0.0	-0.2
Eye problems/disorders: Glaucoma	0.0	0.1	0.3	0.1	-0.1	0.0	0.2	-0.0	-0.6	0.3	-0.3	0.1	-0.0	-0.1
Diastolic blood pressure, automated reading	0.0	0.1	0.3	0.2	-0.1	0.2	-0.1	-0.0	-0.1	0.2	-0.5	-0.3	-0.0	0.5
Vascular/heart problems diagnosed by doctor	0.0	0.0	0.1	-0.1	0.1	0.1	0.0	0.0	0.2	0.3	0.1	0.1	0.0	0.0

Hub : Genes

CLEC12B

Models

Trait associations