Hub : Genes

CD9

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.2520	0.0930	0.00700	-0.009	NA	0.000	NA	-0.009	7.6e-01	NA	3.2e-01	NA	7.9e-01
2	GTEx	Cells Transformed fibroblasts	0.2070	0.0660	0.00310	0.057	NA	0.043	NA	0.051	4.0e-05	NA	3.3e-04	NA	1.0e-04
3	NTR	Blood	0.0346	0.0112	0.00019	0.017	0.013	0.013	0.016	0.016	2.5e-06	2.6e-05	4.4e-05	3.7e-06	4.5e-06
4	YFS	Blood	0.2091	0.0345	0.00000	0.165	0.124	0.158	0.165	0.164	1.4e-51	1.9e-38	3.1e-49	1.1e-51	2.3e-51

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.4	0.6	1.7	0.4	1.3	0.5	0.4
Bipolar Disorder or Schizophrenia	0.5	1.2	4.9	0.2	2.2	-0.1	-0.1
Depressed Affect (Nagel 2018)	1.1	2.3	4.3	1.3	1.7	-2.1	-0.6
Depression (Nagel 2018)	1.1	1.6	5.1	-0.1	2.3	-1.1	0.3
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.9	-0.2	1.4	0.3	-0.2
Neuroticism (Nagel 2018)	0.6	1.5	4.0	0.4	1.2	-2.0	-0.6
Schizophrenia (2018)	0.4	0.9	3.1	-0.2	1.7	-0.4	-0.4
Schizophrenia vs Biploar Disorder	0.3	0.4	0.8	0.9	-0.2	0.8	0.2
Worry (Nagel 2018)	0.3	0.6	0.8	-0.9	0.8	-0.9	-0.3
Alzheimer’s Disease (in mother)	0.4	0.5	1.2	-0.1	-1.1	0.8	-0.3
Alzheimer’s Disease (in father)	0.4	0.4	1.0	0.5	-0.4	1.0	-0.4
Alzheimer’s Disease (including proxy)	0.6	0.8	2.5	0.6	-0.6	1.6	-0.3
Crohns Disease (2017)	0.1	0.3	0.7	-0.5	-0.8	0.0	-0.0
Irritable Bowel Disease (IBD)	0.8	2.0	4.6	-0.7	-2.1	-1.3	-1.1
Ulcerative Colitis (UC)	1.5	2.8	4.8	-0.1	-2.1	-2.2	-1.4
Major Depression (MDD)	0.3	0.4	1.2	0.1	-1.1	-0.4	0.3
Reaction Time	0.2	0.3	0.5	-0.6	-0.5	-0.4	-0.7
Verbal and Numeric Reasoning (VNR)	0.2	0.4	0.9	-0.4	0.7	1.0	0.0
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	0.8	1.1	3.2	-1.1	0.2	-1.8	-0.2
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	1.2	1.8	2.9	1.0	0.6	1.7	1.7
Bipolar Disorder (2011)	1.6	1.5	5.8	0.6	2.4	-0.0	-0.1
Body Mass Index (BMI) (2010)	0.2	0.3	0.8	0.9	0.1	0.4	0.4
Coronary Artery Disease (CAD)	1.2	1.4	3.3	0.4	1.8	-1.2	-0.9
Crohns Disease (2012)	0.6	0.9	1.8	-1.0	-0.2	-1.4	-0.8
Mean Putamen Volume	0.8	0.9	1.7	0.6	-0.7	-1.0	-1.3
Fasting Glucose	0.1	0.2	0.4	-0.1	-0.4	-0.7	0.2
HbA1C	0.9	1.0	2.9	0.8	1.7	-0.4	-0.5
HDL Cholesterol	0.2	0.4	1.0	0.4	0.6	-1.0	0.1
LDL Cholesterol	0.5	0.8	2.4	-0.3	-1.6	0.5	-0.6
Lupus	0.2	0.4	0.9	-0.9	0.4	-0.5	-0.4
Neuroticism (2016)	2.0	2.9	7.1	1.2	-0.3	-2.7	-1.7
Primary Biliary Cirrhosis	0.6	0.8	1.7	0.3	-1.3	-1.0	-0.8
Rheumatoid Arthritis	1.2	1.6	2.3	1.3	0.9	1.5	1.2
Schizophrenia (2014)	0.1	0.1	0.3	0.1	0.5	0.2	0.6
Triglycerides	0.6	1.1	2.2	-1.5	-0.9	1.0	0.5
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.6	-1.3	-0.4	-1.2	-0.2
Ulcerative Colitis	0.6	0.9	1.6	-0.1	-0.9	-1.1	-1.3
Blood Eosinophil Count	0.6	4.4	12.8	3.6	1.0	-0.5	-1.9
Blood Platelet Count	24.8	287.9	707.6	6.9	-0.2	26.6	19.9
Blood Red Count	0.1	1.0	2.4	-1.6	-0.8	0.9	0.1
Blood White Count	0.9	6.6	12.4	2.5	0.5	-3.5	-2.7
Heel T-Score	0.2	1.6	3.5	-1.3	-0.7	-0.7	-1.9
BMI	0.3	1.5	3.3	1.8	-1.5	0.1	0.6
Height	0.1	1.6	4.0	0.7	2.0	1.4	0.5
Waist Hip Ratio (WHR)	0.4	1.8	3.0	-0.4	1.1	1.7	1.7
Systolic Blood Pressure	0.6	3.0	5.7	-2.4	0.5	-2.0	-1.5
Smoking Status	0.2	0.5	0.6	-0.7	0.6	-0.8	0.7
Allergy or Eczema	0.2	0.6	1.4	-0.2	1.2	0.5	-0.9
Cardiovascular Disease	0.1	0.3	0.9	-0.9	-0.3	-0.3	0.3
Hypothyroidism (self reported)	0.4	0.9	1.4	-0.3	1.0	-1.2	-1.2
Respiratory disease	0.5	1.2	1.8	-1.1	-1.4	-1.3	0.1
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.5	-0.9	-0.7	-1.2	-0.1
Lung FEV1/FVC ratio	0.3	1.4	3.6	-0.4	-0.3	1.4	1.9
Lung FVC	0.2	0.9	2.8	-0.0	0.9	-0.0	-1.7
Neuroticism	0.7	1.8	5.7	-0.7	1.0	-2.4	0.0
Chronotype (morning person)	0.6	1.3	3.2	0.1	1.0	-0.9	-1.8
Hair Pigment	0.1	2.9	8.9	3.0	-1.4	-0.8	-0.3
Tanning	0.2	2.8	9.6	-0.5	3.1	0.8	0.8
Hand grip strength (left)	0.1	0.3	1.0	0.3	-1.0	0.2	-0.2
Number of treatments/medications taken	0.3	0.6	1.5	-1.2	0.3	-0.7	-0.6
Average weekly spirits intake	0.9	1.1	1.5	1.2	-0.9	1.2	0.9
Sensitivity / hurt feelings	0.1	0.2	0.5	0.7	0.0	-0.5	0.5
Frequency of depressed mood in last 2 weeks	1.2	1.6	3.6	-0.2	1.9	-1.6	-0.7
Hearing difficulty/problems: Yes	0.5	0.8	1.9	-0.9	0.5	1.4	0.5
Relative age of first facial hair	1.2	2.4	6.2	-0.7	-0.8	-2.5	-1.5
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	2.5	-1.6	1.0	0.4	-0.6
Ever used hormone-replacement therapy (HRT)	0.8	1.0	1.7	-0.2	1.3	1.0	1.0
Ever had hysterectomy (womb removed)	1.3	1.5	3.4	0.7	1.2	1.8	0.9
Systolic blood pressure, automated reading	0.6	1.7	2.8	-1.7	0.9	-1.3	-1.2
Eye problems/disorders: Diabetes related eye disease	1.7	1.9	3.3	1.5	-0.7	-1.8	-1.1
Angina	0.4	0.5	1.7	-1.3	-0.4	-0.5	-0.1
Medication for hormone replacement therapy	0.8	0.8	2.3	-0.9	1.5	0.1	0.5
Vitamin and mineral supplements	0.1	0.2	0.3	-0.4	-0.4	0.0	0.6
Supplements: Zinc	0.6	0.6	1.5	-0.2	-0.7	1.2	0.6
Medication: Co-codamol	2.0	2.3	3.9	-1.7	0.5	-2.0	-1.4
Medication: Metformin	0.6	0.8	1.1	-0.9	-0.8	1.0	0.7
Diabetes (father)	0.5	0.6	1.2	0.6	-0.8	1.1	0.7
Diabetes (mother)	0.9	1.2	4.1	-2.0	0.7	0.2	0.2
Severe depression (siblings)	0.6	0.7	2.6	-0.1	0.3	1.6	0.3
Pack years adult smoking proportion	1.5	2.3	6.3	-0.2	0.2	2.5	1.7
Impedance of leg (right)	0.4	2.2	4.6	-2.1	1.2	-1.1	-1.1
Leg fat-free mass (left)	0.3	1.7	3.5	1.9	-1.6	0.8	-0.0
Trunk fat percentage	0.1	0.5	1.4	1.2	-0.6	-0.2	-0.4
Hand grip strength (right)	0.3	0.8	2.2	1.5	-0.8	0.6	-0.1
Townsend deprivation index at recruitment	1.0	1.4	2.8	-0.7	-1.1	1.7	1.1
Current tobacco smoking	0.4	0.6	1.5	-1.2	-0.5	-0.9	-0.1
Average weekly fortified wine intake	1.0	1.2	3.1	1.8	-0.4	1.2	0.1
Maternal smoking around birth	2.5	3.6	5.5	-2.2	0.0	-2.4	-2.0
Fed-up feelings	0.7	1.2	2.9	1.2	0.6	-1.7	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	2.0	0.0	1.4	-0.7	0.3
Relative age voice broke	0.1	0.2	0.5	-0.7	0.1	0.2	-0.2
Taking other prescription medications	0.4	0.6	2.4	-1.6	0.1	-0.1	-0.4
Age when periods started (menarche)	0.2	0.4	1.2	1.1	0.3	0.0	-0.6
Bilateral oophorectomy (both ovaries removed)	3.5	4.1	7.8	-0.2	0.8	2.8	2.8
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	1.8	-1.1	0.3	-1.3	-1.2
Tinnitus: Yes, but not now, but have in the past	1.8	1.9	5.8	-2.4	0.9	-0.9	-0.1
Qualifications: CSEs or equivalent	2.1	2.8	6.5	-1.2	-1.4	-2.5	-1.1
Serious illness, injury or assault to yourself	0.9	1.1	3.1	0.1	1.1	-1.8	-0.3
High blood pressure	0.7	1.8	6.6	-2.6	0.1	0.6	0.7
Hayfever, allergic rhinitis or eczema	0.2	0.3	0.7	-0.3	0.8	-0.0	-0.8
Multivitamins +/- minerals	0.9	1.1	2.0	1.4	-0.6	-0.6	-1.3
Stomach or abdominal pain in last month	0.6	0.7	1.3	-0.7	1.1	-1.1	0.1
Supplements: Glucosamine	3.3	4.3	12.9	3.6	-1.5	1.4	0.1
Diverticular disease/diverticulitis (self-reported)	1.7	2.0	5.4	1.4	2.3	-0.5	-0.5
Medication: Atenolol	1.5	1.9	5.9	-1.2	2.4	-0.2	-0.0
Medication: Levothyroxine sodium	0.1	0.2	0.5	-0.6	0.3	-0.1	-0.7
Sitting height	0.2	1.1	2.5	1.1	-0.3	1.6	0.8
Chronic bronchitis/emphysema (father)	1.7	2.0	4.2	-0.7	0.5	-2.1	-1.7
High blood pressure (mother)	1.6	2.2	7.9	-2.8	0.8	-0.4	0.3
Body mass index (BMI)	0.2	0.9	1.9	1.1	-1.4	0.7	0.3
Impedance of leg (left)	0.3	1.3	3.7	-1.9	1.0	-0.7	-0.5
Leg predicted mass (left)	0.3	1.7	3.5	1.9	-1.6	0.7	-0.1
Trunk fat mass	0.2	0.7	1.5	1.2	-1.1	0.3	-0.0
Waist circumference	0.2	0.8	1.7	0.5	-0.9	1.3	0.6
Number of incorrect matches in round	0.3	0.5	1.5	-1.2	0.2	-0.4	0.3
Past tobacco smoking	0.6	1.2	3.2	-0.1	-1.2	0.1	-1.8
Alcohol usually taken with meals	0.2	0.4	0.5	0.3	0.7	0.6	0.7
Nervous feelings	0.2	0.5	1.4	-0.5	1.2	-0.4	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	3.3	0.3	1.8	0.3	0.5
Hearing difficulty/problems with background noise	1.0	1.5	3.6	-1.5	0.4	1.9	0.2
Hair/balding pattern: Pattern 2	0.3	0.3	0.6	-0.3	0.8	-0.4	-0.6
Had menopause	0.6	0.7	1.7	0.6	1.3	0.7	0.4
Had other major operations	2.7	3.3	10.2	-3.2	1.2	-0.8	-0.9
Forced vital capacity (FVC)	0.1	0.4	1.2	-0.4	0.2	-0.6	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.2	-1.1	0.2	-0.4	-0.7
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	3.6	1.9	0.5	0.2	-0.0
Qualifications: None of the above	0.1	0.3	0.6	0.4	0.8	-0.5	0.3
Financial difficulties in last 2 years	0.7	0.9	1.7	-0.2	0.9	1.1	1.3
Mouth/teeth dental problems	0.5	0.8	3.1	1.8	-0.2	0.1	0.3
Heart attack	0.8	1.0	1.8	-1.3	-0.7	-1.3	-0.3
Allergy	0.2	0.5	1.2	0.1	-0.5	0.9	1.1
Pain all over the body in last month	0.3	0.3	0.7	-0.5	0.2	-0.4	-0.8
Diabetes (self-reported)	0.3	0.4	0.9	-0.8	-0.5	-0.9	-0.1
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.4	-0.1	1.2	0.0	-1.1
Medication: Ramipril	3.7	4.8	11.2	-3.4	0.9	1.9	1.9
Medication: Simvastatin	0.5	0.8	1.4	-1.1	-0.8	-1.2	0.1
Fluid intelligence score	0.4	0.7	1.2	-0.7	-1.0	1.1	0.4
Illnesses of siblings	0.2	0.3	1.3	-0.0	0.1	-0.1	-1.1
Neuroticism score	0.5	1.0	3.1	0.4	0.8	-1.8	-0.3
Weight	0.3	1.7	3.0	1.5	-1.7	1.2	0.4
Impedance of arm (right)	0.5	2.6	5.1	-0.6	1.5	-2.3	-1.6
Arm fat percentage (right)	0.1	0.5	1.0	0.5	-1.0	-0.6	-0.6
Trunk fat-free mass	0.4	2.3	4.1	0.6	-2.0	2.0	1.0
Hip circumference	0.2	0.8	2.6	0.6	-1.6	0.3	0.0
Time employed in main current job	0.6	0.7	1.8	0.1	0.8	-1.4	-0.7
Alcohol intake versus 10 years previously	1.0	1.5	3.2	-0.9	-1.8	1.0	1.0
Father’s age at death	0.6	0.7	1.4	-1.0	1.2	0.6	-0.4
Worrier / anxious feelings	0.9	1.7	5.2	2.3	-0.1	-1.1	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	2.1	-0.6	-0.7	-1.5	-1.3
Falls in the last year	0.0	0.0	0.1	0.1	0.3	0.0	0.3
Hair/balding pattern: Pattern 3	0.7	1.0	1.9	1.1	-1.4	0.0	-0.9
Number of live births	1.2	1.7	4.9	-2.2	0.8	-0.7	-0.8
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.6	-0.3	-0.4	-0.7	-1.3
Pulse rate	0.8	1.4	2.2	0.5	1.4	1.2	1.5
Happiness	0.4	0.5	2.0	-0.1	1.4	-0.5	0.0
Noisy workplace	0.2	0.3	0.5	-0.3	0.5	-0.7	-0.5
Qualifications: A levels/AS levels or equivalent	0.5	1.0	1.9	0.1	-1.0	-1.0	-1.4
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	1.0	1.0	0.9	-0.0	-0.5
Mouth/teeth dental problems: Dentures	0.5	0.9	3.0	-1.7	0.6	0.1	-0.1
Asthma	0.4	0.9	1.5	0.1	-1.1	-1.2	-0.9
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	2.8	0.7	-0.6	-0.8	-1.7
Medication: Cholesterol lowering	0.1	0.1	0.4	-0.2	0.1	-0.7	0.2
Depression (self-reported)	0.9	1.1	2.5	1.6	0.3	-0.9	-1.0
Medication: Lansoprazole	0.5	0.6	1.7	-0.4	1.3	0.5	-0.4
Prospective memory result	0.7	0.9	1.9	-0.4	-0.5	1.4	1.1
Lung cancer (father)	1.0	1.2	2.8	0.6	-0.1	-1.7	-1.3
Illnesses of mother	0.7	0.9	2.7	1.6	-1.0	-0.1	-0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	2.6	0.7	-0.5	-0.7	-1.6
Pulse wave Arterial Stiffness index	0.3	0.3	0.5	-0.7	-0.1	0.6	0.7
Impedance of arm (left)	0.5	2.2	3.4	0.4	1.5	-1.8	-1.7
Arm fat mass (right)	0.2	0.7	2.2	0.6	-1.5	0.2	-0.1
Trunk predicted mass	0.4	2.4	4.3	0.8	-2.0	2.1	1.0
Standing height	0.1	0.8	1.6	1.0	-0.7	1.3	0.3
Length of working week for main job	0.2	0.2	0.7	-0.8	-0.3	0.3	0.3
Exposure to tobacco smoke at home	1.7	1.9	2.3	-1.5	1.5	-1.1	-1.4
Breastfed as a baby	0.3	0.3	1.3	1.1	-0.1	-0.3	0.0
Tense / ‘highly strung’	0.9	1.5	4.3	-0.9	2.1	-0.7	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.5	0.7	0.5	0.2	0.2
Hair/balding pattern: Pattern 4	0.1	0.2	0.5	-0.3	-0.7	-0.2	0.2
Birth weight of first child	0.9	1.6	2.3	1.4	-1.0	1.5	0.9
Peak expiratory flow (PEF)	0.3	0.6	1.7	0.5	-1.3	0.5	-0.3
Pulse wave reflection index	0.4	0.5	1.3	-0.5	-1.1	-0.5	-0.2
Ever highly irritable/argumentative for 2 days	1.8	2.1	5.4	1.2	2.3	0.8	1.1
Loud music exposure frequency	0.2	0.2	0.7	-0.4	0.9	0.1	-0.1
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	1.9	-0.2	-0.6	0.8	1.4
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.7	-0.7	0.5	0.3	-0.8
Blood clot in the leg (DVT)	0.1	0.1	0.2	-0.3	-0.5	-0.1	-0.0
Medication: Paracetamol	1.0	1.7	3.1	0.6	0.4	-1.8	-1.8
Headache pain in last month	0.9	1.5	4.8	-0.1	0.3	-2.2	-1.1
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	1.9	0.7	-0.5	-1.3	-1.4
Glaucoma (self-reported)	0.3	0.4	1.0	1.0	0.3	-0.6	-0.1
Gout (self-reported)	0.3	0.5	1.1	-1.1	0.7	-0.5	0.1
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	2.1	-0.5	0.6	-1.3	-1.4
Medication: Amlodipine	0.3	0.5	0.9	-0.5	-1.0	0.1	0.8
Medication: Ventolin 100micrograms inhaler	1.1	1.4	4.7	-0.1	0.5	-2.2	-0.8
Birth weight	0.6	1.4	3.0	0.1	1.0	1.7	1.2
Chronic bronchitis/emphysema (mother)	1.2	1.4	3.1	-0.0	-1.8	0.8	1.3
High blood pressure (siblings)	0.2	0.3	0.5	-0.7	-0.4	-0.7	0.4
Forced vital capacity (FVC), Best measure	0.1	0.4	1.1	0.6	-0.1	-0.2	-1.0
Body fat percentage	0.1	0.3	0.7	0.8	-0.6	-0.1	-0.4
Leg fat percentage (right)	0.0	0.1	0.1	0.1	-0.3	-0.1	-0.3
Arm fat-free mass (right)	0.4	2.2	4.1	1.1	-1.8	2.0	0.7
Exposure to tobacco smoke outside home	0.8	1.1	3.3	-1.8	0.8	0.6	0.5
Comparative body size at age 10	0.4	1.0	1.7	1.1	-0.1	1.3	1.1
Number of full brothers	0.7	0.9	1.4	-0.2	-1.1	-0.9	-1.2
Worry too long after embarrassment	0.7	1.2	4.2	0.1	-0.5	-2.1	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.0	0.0	0.1	-0.1	-0.2	-0.1	0.3
Wheeze or whistling in the chest in last year	1.2	2.1	5.0	-0.8	1.5	-2.2	-0.6
Number of children fathered	1.1	1.2	2.2	0.4	1.3	-0.9	-1.5
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.5	-0.4	-0.7	0.2	-0.0
Age at first live birth	0.6	1.1	3.1	1.8	1.2	0.3	-0.2
Pulse wave peak to peak time	0.3	0.3	0.5	0.7	0.2	-0.5	-0.7
Health satisfaction	0.5	0.6	1.0	0.8	0.8	-1.0	-0.3
Shortness of breath walking on level ground	0.3	0.3	0.8	0.0	-0.1	-0.6	-0.9
Qualifications: College or University degree	0.2	0.7	2.2	0.6	0.1	-0.3	-1.5
Eye problems/disorders: None of the above	0.2	0.3	0.4	0.3	0.5	0.5	0.7
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.4	0.1	-0.2	-0.6	-0.2
Emphysema/chronic bronchitis	1.7	2.0	5.8	-0.3	-1.0	-2.4	-1.0
Medication for pain relief, constipation, heartburn	1.0	1.7	3.6	0.3	0.5	1.9	1.7
Neck or shoulder pain in last month	0.6	0.8	1.6	0.6	0.7	-0.9	-1.3
Medication: Blood pressure	1.1	2.0	3.7	-1.5	0.1	1.9	1.4
Angina (self-reported)	0.4	0.5	1.6	-1.3	-0.5	-0.2	-0.1
Migraine (self-reported)	3.4	4.2	8.5	-0.6	-1.6	-2.9	-2.3
Medication: Ibuprofen	0.7	0.9	2.0	1.4	-0.0	-0.2	-1.2
Medication: Allopurinol	0.2	0.2	0.8	-0.9	0.1	-0.2	0.3
Medication: Omeprazole	1.2	1.4	5.3	-2.3	-0.1	-0.4	-0.2
Medication: Seretide 50 evohaler	0.6	0.7	1.7	1.3	-0.8	-0.3	0.4
Mean time to correctly identify matches	0.4	0.7	2.2	-0.0	0.7	0.4	1.5
Heart disease (mother)	0.2	0.2	0.4	0.3	0.6	-0.3	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.9	3.1	-1.8	0.4	0.3	0.1
Whole body fat mass	0.2	0.7	1.3	1.1	-1.1	0.5	0.2
Leg fat mass (right)	0.1	0.4	1.1	0.6	-1.0	0.4	0.0
Arm predicted mass (right)	0.4	2.0	3.8	0.8	-1.7	2.0	0.8
Pulse rate, automated reading	0.2	0.6	1.3	-1.0	1.2	0.3	0.2
Alcohol intake frequency.	0.2	0.5	1.4	-0.5	0.4	1.2	-0.4
Comparative height size at age 10	0.4	2.1	5.7	0.5	-0.4	2.4	1.5
Number of full sisters	1.0	1.2	3.6	-1.9	-0.1	0.3	1.0
Suffer from ‘nerves’	0.8	1.2	2.3	-1.5	-0.9	1.0	0.9
Overall health rating	0.3	0.7	1.1	-1.0	0.3	-1.0	-0.8
Chest pain or discomfort	0.5	0.8	1.5	-1.2	0.4	-0.1	1.2
Had major operations	0.5	0.6	0.9	0.9	-0.4	-0.7	-0.9
Age at last live birth	0.2	0.3	0.5	0.6	-0.1	-0.7	-0.7
Family relationship satisfaction	0.2	0.2	0.7	-0.4	0.8	0.1	0.1
Leg pain on walking	0.5	0.6	1.9	1.4	-0.2	-0.7	-0.3
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.7	5.7	0.9	-2.4	-0.0	-0.5
Commuting to job workplace: Car/motor vehicle	1.1	1.2	3.4	-0.7	0.3	-1.8	-1.0
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	0.7	-0.7	-0.8	-0.2	-0.3
Medication: Aspirin	0.4	0.6	1.5	-0.5	0.7	-1.2	-0.1
Supplements: Vitamin C	0.3	0.4	1.0	-0.4	-1.0	0.5	-0.6
Knee pain experienced in last month	0.1	0.1	0.2	0.0	-0.1	-0.3	-0.5
Hypertension (Self-reported)	0.9	2.6	8.1	-2.9	-0.3	1.1	1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.9	-0.5	1.4	-0.1	-0.3
Illnesses of father: Heart disease	0.9	1.3	2.3	-1.0	1.5	1.2	0.4
Illnesses of siblings: Diabetes	1.1	1.3	2.8	-0.6	0.0	1.7	1.4
Smoking status: Previous	0.2	0.3	0.6	-0.3	0.5	-0.6	0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.8	3.9	-1.5	-2.0	-0.3	-1.0
Whole body fat-free mass	0.4	2.1	3.5	1.2	-1.9	1.7	0.7
Leg fat-free mass (right)	0.3	1.8	3.6	1.9	-1.6	0.9	0.2
Arm fat percentage (left)	0.1	0.6	1.0	0.9	-1.0	-0.3	-0.6
Average weekly red wine intake	0.6	0.8	1.9	0.5	0.7	1.4	0.8
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.3	-0.1	-1.2	-0.1	0.4
Mood swings	2.1	3.8	10.6	3.3	1.0	-1.9	-0.1
Loneliness, isolation	1.6	2.1	6.7	1.3	2.6	-0.3	-0.4
Long-standing illness, disability or infirmity	1.2	1.8	3.4	-1.3	0.0	-1.9	-1.4
Ever had bowel cancer screening	1.2	1.4	2.6	-0.7	1.5	-1.6	-0.8
Diabetes diagnosed by doctor	0.5	0.8	2.2	-0.8	-0.2	-1.5	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	2.8	1.7	1.0	-0.3	-0.5
Friendships satisfaction	0.4	0.5	1.3	0.8	0.3	-1.1	-0.4
Qualifications: nursing, teaching	0.3	0.5	1.4	1.2	0.5	-0.3	0.2
Commuting to job workplace: Walk	0.9	0.9	1.5	-1.2	0.6	1.1	0.8
Eye problems/disorders: Cataract	0.6	0.7	1.2	-1.0	-0.1	-0.7	-1.1
Mouth/teeth dental problems: Mouth ulcers	0.0	0.1	0.2	-0.1	0.2	-0.4	-0.1
Medication for cholesterol	0.2	0.3	0.7	0.5	-0.1	0.9	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	2.9	-0.3	-0.1	-1.0	-1.7
Back pain experienced in last month	1.1	1.5	3.1	0.6	1.8	1.4	0.9
Mineral and other dietary supplements	0.8	1.0	2.6	-1.6	-0.8	-0.8	-0.6
Breast cancer (self-reported)	1.4	1.7	4.1	-2.0	1.3	-0.5	-0.9
Asthma (self-reported)	0.6	1.1	2.1	0.3	-1.2	-1.5	-0.9
Osteoporosis (self-reported)	0.5	0.6	1.6	-0.2	0.0	-1.0	-1.2
Osteoarthritis (self-reported)	0.3	0.4	0.6	0.8	0.7	0.1	-0.7
Medication: Aspirin	0.3	0.3	0.6	-0.8	0.6	-0.7	0.1
Medication: Gliclazide	0.6	0.7	1.8	-0.0	0.4	-1.0	-1.3
Illnesses of father: None of the above (group 1)	0.4	0.4	1.2	0.6	-1.1	0.4	0.2
Smoking status: Current	0.1	0.2	0.6	-0.8	-0.0	-0.3	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.5	1.1	0.8	0.6	-0.3	-1.0
Whole body water mass	0.4	2.0	3.5	1.1	-1.9	1.7	0.7
Leg predicted mass (right)	0.3	1.8	3.5	1.9	-1.5	1.0	0.3
Arm fat mass (left)	0.2	0.9	2.5	1.1	-1.6	0.3	-0.1
Number of self-reported non-cancer illnesses	1.1	2.0	4.4	-0.9	0.0	-2.1	-1.6
Average weekly champagne plus white wine intake	0.3	0.5	0.8	-0.5	-0.6	0.9	0.7
Miserableness	0.7	1.2	2.2	1.5	0.9	-1.0	0.8
Guilty feelings	0.5	0.7	1.4	0.4	1.1	-1.2	0.3
Wears glasses or contact lenses	0.5	0.6	0.8	0.8	0.9	0.7	0.5
Ever taken oral contraceptive pill	0.9	1.0	3.1	-1.8	0.3	-0.8	0.4
Hearing aid user	0.9	1.0	2.7	-0.3	0.8	-0.8	-1.6
Mother’s age at death	1.4	1.8	3.5	-0.7	1.3	1.9	1.3
Financial situation satisfaction	0.6	0.8	1.4	-0.9	0.0	-1.0	-1.2
Tinnitus: Yes, now most or all of the time	0.9	1.1	2.9	0.0	-1.0	1.7	0.6
Commuting to job workplace: Public transport	0.1	0.1	0.2	-0.0	-0.2	0.4	0.4
Eye problems/disorders: Glaucoma	0.6	0.7	2.6	1.6	-0.2	0.3	0.5
Medication: Blood pressure	0.9	1.7	6.0	-2.4	-0.0	-0.5	0.7
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.0	1.0	-0.3	1.0	0.2
Supplements: Fish oil (including cod liver oil)	0.5	0.6	1.5	1.2	0.9	-0.2	-0.1
High cholesterol (Self-reported)	0.1	0.2	0.4	0.5	0.4	-0.7	-0.2
Medication: Bendroflumethiazide	0.1	0.2	0.3	-0.5	0.4	0.5	0.3
Medication: Paracetamol	1.1	1.7	2.4	1.6	0.9	-1.4	-1.2
Medication: Lisinopril	0.6	0.8	1.1	-0.2	1.1	0.9	1.1
Medication: Atorvastatin	0.3	0.3	0.8	0.9	0.4	-0.3	-0.5
Illnesses of father: High blood pressure	0.9	1.2	3.8	-1.9	0.8	0.3	0.4
Alcohol drinker status: Never	1.8	2.2	4.7	-0.5	2.2	2.0	0.2
Ever smoked	0.9	1.5	3.0	-0.5	1.7	-1.1	1.3
Basal metabolic rate	0.4	2.0	4.3	1.2	-2.1	1.4	0.5
Leg fat percentage (left)	0.0	0.1	0.2	0.2	-0.4	0.4	0.3
Arm fat-free mass (left)	0.3	1.6	3.6	0.4	-1.9	1.5	0.5
Number of operations (self-reported)	1.3	2.0	7.8	-2.8	-0.0	0.1	-0.4
Average weekly beer plus cider intake	0.4	0.6	1.0	0.7	-1.0	-0.9	-0.5
Irritability	0.7	1.3	3.8	1.9	0.6	-0.9	-0.3
Risk taking	0.5	0.7	1.6	-0.8	0.3	-0.7	-1.3
Ever had prostate specific antigen (PSA) test	1.0	1.2	3.7	0.2	1.9	-1.0	-0.2
Fractured/broken bones in last 5 years	1.1	1.4	4.3	-2.1	-0.6	0.5	0.9
Age started oral contraceptive pill	0.1	0.1	0.4	0.3	0.2	-0.3	0.6
Diastolic blood pressure, automated reading	0.2	0.7	2.3	-1.5	-0.4	0.6	0.0
Ever depressed for a whole week	0.8	1.0	2.8	1.7	-0.3	0.7	0.7
Unable to work because of sickness or disability	1.7	2.2	4.6	-1.4	-0.2	-1.5	-2.1
Commuting to job workplace: Cycle	0.4	0.5	1.3	0.5	-0.3	-0.4	-1.1
Myopia	0.3	0.4	0.9	-0.5	0.0	-0.9	-0.7
Vascular/heart problems diagnosed by doctor	0.6	1.5	5.2	2.3	0.3	-0.5	-0.8
Cholesterol lowering medication	0.2	0.2	0.7	-0.4	-0.2	-0.8	-0.0
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	2.6	-1.6	0.2	0.1	0.5
Pain experienced in last month	0.5	0.8	1.4	1.2	-0.7	0.6	1.1
Supplements: Calcium	1.5	1.7	3.2	-1.8	-0.8	1.5	0.7
Basal cell carcinoma (self-reported)	1.2	1.4	3.5	-1.2	-1.9	-0.2	-0.7
Heart attack/myocardial infarction (self-reported)	0.8	1.1	2.3	-1.5	-0.4	-1.3	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.0	0.0	0.1	0.0	0.0	-0.2	-0.1
Heart disease (siblings)	0.1	0.1	0.4	0.6	0.2	-0.1	0.1
Alcohol drinker status: Previous	0.3	0.3	0.6	-0.7	-0.8	-0.3	-0.3
Pack years of smoking	2.2	3.2	7.9	-0.2	0.6	2.8	2.2
Impedance of whole body	0.3	1.7	2.5	-0.7	1.3	-1.6	-1.4
Leg fat mass (left)	0.1	0.5	1.2	0.6	-1.1	0.7	0.3
Arm predicted mass (left)	0.4	1.9	3.4	0.6	-1.8	1.8	0.8