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chr14:72,734,342-76,226,003

Best TWAS P=5.05e-13 · Best GWAS P=3.73e-14 conditioned to 9.94e-61

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
20	GTEx	Skin Not Sun Exposed Suprapubic	RPS6KL1	0.08	0.08	enet	11	0.07	1.5e-04	-5.7	-7.2	5.0e-13	-0.72	0.15	0.83	TRUE
25	METSIM	Adipose	PNMA1	0.09	0.01	lasso	6	0.03	1.9e-05	-4.4	6.7	2.7e-11	-0.05	0.66	0.01	TRUE
6	GTEx	Adipose Visceral Omentum	PSEN1	0.11	0.02	enet	16	0.00	2.3e-01	-6.8	6.4	1.7e-10	-0.03	0.01	0.95	TRUE
34	The Cancer Genome Atlas	Stomach Adenocarcinoma	C14orf169	0.06	0.01	enet	6	0.02	1.8e-02	-6.2	-6.2	5.6e-10	0.04	0.00	0.75	TRUE
27	The Cancer Genome Atlas	Breast Invasive Carcinoma	C14orf169	0.06	0.00	blup	41	0.02	2.4e-04	2.4	-5.8	6.2e-09	0.08	0.03	0.83	TRUE
9	GTEx	Artery Aorta	PNMA1	0.23	0.12	enet	23	0.14	2.7e-08	-4.0	5.5	2.9e-08	-0.04	0.63	0.36	TRUE
13	GTEx	Cells Transformed fibroblasts	COQ6	0.16	0.10	enet	22	0.12	3.6e-09	3.9	5.2	1.5e-07	-0.08	1.00	0.00	TRUE
1	CommonMind	Brain Pre-frontal Cortex	ACOT1	0.68	0.27	lasso	13	0.46	5.1e-63	-6.3	5.2	1.6e-07	-0.05	0.02	0.98	TRUE
19	GTEx	Nerve Tibial	RP4-647C14.3	0.16	0.05	enet	10	0.07	9.4e-06	-5.5	-5.2	1.7e-07	0.03	0.20	0.50	TRUE
32	The Cancer Genome Atlas	Lung Adenocarcinoma	HEATR4	0.08	0.00	blup	54	0.00	3.1e-01	-5.0	5.2	1.8e-07	-0.03	0.01	0.12	TRUE
4	GTEx	Adipose Subcutaneous	PSEN1	0.07	0.03	enet	7	0.02	5.1e-03	-4.4	5.2	2.3e-07	-0.01	0.10	0.52	TRUE
2	CommonMind	Brain Pre-frontal Cortex	DLST	0.09	0.11	lasso	2	0.11	4.0e-13	7.2	-7.1	1.3e-12	-0.66	0.16	0.84	FALSE
16	GTEx	Muscle Skeletal	DLST	0.28	0.26	enet	23	0.26	2.1e-25	7.1	6.9	4.8e-12	0.93	0.09	0.91	FALSE
5	GTEx	Adipose Subcutaneous	YLPM1	0.10	0.03	lasso	6	0.02	7.9e-03	6.6	-6.6	3.5e-11	-0.77	0.08	0.45	FALSE
33	The Cancer Genome Atlas	Lung Adenocarcinoma	RPS6KL1	0.03	0.01	blup	49	0.02	2.3e-03	-5.3	-6.4	1.4e-10	-0.72	0.04	0.32	FALSE
3	CommonMind	Brain Pre-frontal Cortex	RPS6KL1	0.04	0.02	lasso	5	0.02	4.8e-04	-5.0	6.3	2.7e-10	0.67	0.08	0.78	FALSE
31	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	RPS6KL1	0.09	0.10	blup	49	0.11	5.1e-07	5.2	-6.2	6.7e-10	-0.76	0.72	0.25	FALSE
29	The Cancer Genome Atlas	Breast Invasive Carcinoma	RPS6KL1	0.03	0.02	lasso	3	0.02	8.5e-06	-6.2	-6.2	7.6e-10	-0.58	0.91	0.08	FALSE
23	GTEx	Testis	AREL1	0.20	0.14	enet	34	0.13	2.1e-06	-6.2	-6.1	9.2e-10	-0.57	0.84	0.15	FALSE
30	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RPS6KL1	0.04	0.04	lasso	3	0.03	1.8e-04	-6.2	-6.1	1.1e-09	-0.59	0.53	0.16	FALSE
24	METSIM	Adipose	ACYP1	0.03	0.02	blup	413	0.02	4.0e-04	4.3	-6.0	2.0e-09	-0.63	0.62	0.32	FALSE
10	GTEx	Artery Aorta	ACOT1	0.45	0.09	lasso	11	0.23	8.4e-13	3.5	5.9	4.3e-09	-0.02	0.30	0.68	FALSE
12	GTEx	Artery Coronary	NUMB	0.14	0.00	enet	8	-0.01	7.9e-01	2.4	-5.8	4.8e-09	0.03	0.07	0.24	FALSE
26	METSIM	Adipose	YLPM1	0.04	0.00	bslmm	380	0.01	2.7e-03	2.5	-5.8	5.8e-09	-0.47	0.09	0.13	FALSE
18	GTEx	Nerve Tibial	RPS6KL1	0.17	0.24	lasso	6	0.19	2.3e-13	-5.1	-5.7	1.4e-08	-0.59	1.00	0.00	FALSE
11	GTEx	Artery Aorta	RP11-950C14.3	0.17	0.11	lasso	10	0.16	6.0e-09	3.8	-5.6	1.9e-08	-0.71	0.62	0.38	FALSE
8	GTEx	Adrenal Gland	RPS6KL1	0.21	0.13	enet	25	0.15	4.4e-06	-5.0	-5.6	2.3e-08	-0.45	0.57	0.27	FALSE
21	GTEx	Skin Not Sun Exposed Suprapubic	RP11-950C14.3	0.07	0.03	enet	8	0.03	1.2e-02	4.2	-5.6	2.4e-08	-0.53	0.26	0.30	FALSE
7	GTEx	Adipose Visceral Omentum	RPS6KL1	0.12	0.09	lasso	2	0.08	3.7e-05	-4.8	-5.4	5.9e-08	-0.63	0.46	0.47	FALSE
14	GTEx	Colon Transverse	RP11-109N23.6	0.16	0.01	enet	19	0.02	5.6e-02	3.7	5.3	9.9e-08	-0.02	0.35	0.27	FALSE
28	The Cancer Genome Atlas	Breast Invasive Carcinoma	HEATR4	0.10	0.06	blup	54	0.06	7.4e-13	-5.0	5.3	1.0e-07	0.00	0.90	0.10	FALSE
17	GTEx	Nerve Tibial	YLPM1	0.08	0.06	lasso	1	0.04	5.1e-04	-5.3	-5.3	1.2e-07	-0.52	0.20	0.37	FALSE
22	GTEx	Skin Sun Exposed Lower leg	RPS6KL1	0.15	0.13	lasso	4	0.12	1.8e-10	-4.8	-5.2	2.2e-07	-0.50	1.00	0.00	FALSE
15	GTEx	Esophagus Mucosa	RPS6KL1	0.18	0.12	lasso	5	0.12	3.3e-08	5.2	-5.2	2.3e-07	-0.72	0.29	0.71	FALSE