Hub : Genes

HEATR4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2160	0.0500	2.4e-08	0.052	0.093	0.108	0.102	0.109	5.3e-07	2.2e-11	4.2e-13	1.9e-12	3.5e-13
2	METSIM	Adipose	0.1103	0.0320	4.0e-07	0.018	0.063	0.061	0.066	0.042	9.1e-04	8.5e-10	2.0e-09	3.9e-10	6.5e-07
3	NTR	Blood	0.0154	0.0081	9.8e-03	0.002	0.009	0.005	0.009	0.006	4.8e-02	5.5e-04	6.2e-03	4.7e-04	5.1e-03
4	TCGA	Breast Invasive Carcinoma	0.1012	0.0275	5.6e-17	0.065	0.063	0.061	NA	0.060	3.5e-13	7.4e-13	1.5e-12	NA	2.4e-12
5	TCGA	Head and Neck Squamous Cell Carcinoma	0.0928	0.0387	7.3e-04	-0.001	0.001	0.003	NA	0.000	4.2e-01	2.5e-01	1.5e-01	NA	3.6e-01
6	TCGA	Liver Hepatocellular Carcinoma	0.1820	0.0640	2.3e-05	0.042	0.083	0.077	NA	0.088	4.8e-03	1.0e-04	1.8e-04	NA	6.1e-05
7	TCGA	Lung Adenocarcinoma	0.0801	0.0428	3.1e-03	0.001	0.000	-0.002	NA	-0.001	2.3e-01	3.1e-01	9.2e-01	NA	4.7e-01
8	TCGA	Ovarian Serous Cystadenocarcinoma	0.0820	0.0390	7.8e-04	0.018	0.034	0.025	NA	0.019	2.2e-02	2.3e-03	8.1e-03	NA	1.7e-02
9	TCGA	Pancreatic Adenocarcinoma	0.2130	0.0760	2.4e-05	0.037	0.087	0.074	NA	0.091	1.1e-02	1.7e-04	4.9e-04	NA	1.2e-04
10	TCGA	Thyroid Carcinoma	0.0630	0.0290	4.2e-04	0.005	0.017	0.007	NA	0.005	1.1e-01	7.4e-03	5.8e-02	NA	9.2e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.3	0.4	2.2	0.5	0.1	-1.5	0.3	-0.1	-0.8	-0.1	0.8	-0.2	0.7
Bipolar Disorder or Schizophrenia	2.2	5.4	11.5	-1.3	-2.4	-1.9	3.4	2.5	2.2	2.4	2.1	2.0	2.5
Depressed Affect (Nagel 2018)	0.5	1.0	1.7	-1.3	-0.8	-0.7	1.1	1.0	0.8	1.3	0.5	1.2	1.1
Depression (Nagel 2018)	0.2	0.4	0.8	-0.5	-0.8	-0.4	0.9	0.3	0.4	0.8	-0.1	0.9	0.3
Intelligence (Savage-Jansen 2018)	1.1	3.3	10.6	-1.0	3.3	-2.6	-0.6	-0.4	-2.1	0.9	2.3	1.2	1.6
Neuroticism (Nagel 2018)	0.3	0.7	1.7	-0.6	0.2	-1.3	1.1	0.4	0.4	0.8	0.8	0.8	1.0
Schizophrenia (2018)	4.3	8.9	18.3	-2.1	-3.2	-1.2	4.3	3.7	3.4	3.1	2.1	2.8	2.7
Schizophrenia vs Biploar Disorder	1.1	1.5	8.7	-0.5	-1.4	0.4	1.4	1.1	2.9	0.6	-0.4	0.4	0.5
Worry (Nagel 2018)	0.2	0.4	1.2	-0.4	0.7	-0.7	0.8	-0.2	0.1	0.7	0.8	0.4	1.1
Alzheimer’s Disease (in mother)	11.1	13.0	22.3	3.5	4.7	-0.2	-4.6	-3.9	-4.1	-4.0	-2.1	-3.5	-3.1
Alzheimer’s Disease (in father)	2.7	3.0	5.0	1.7	1.5	1.9	-1.8	-1.2	-0.7	-2.2	-2.0	-1.7	-1.9
Alzheimer’s Disease (including proxy)	7.3	10.6	16.3	3.3	4.0	0.7	-3.7	-3.7	-3.8	-3.7	-2.2	-3.1	-2.8
Crohns Disease (2017)	0.3	0.7	1.4	-1.0	0.7	-0.3	1.0	0.6	0.6	0.7	1.1	0.9	1.2
Irritable Bowel Disease (IBD)	0.6	1.3	3.1	-1.5	-0.1	-0.5	1.2	0.3	0.6	1.4	1.3	1.5	1.8
Ulcerative Colitis (UC)	0.5	1.0	2.5	-1.2	-0.9	-0.4	0.8	-0.1	0.5	1.3	0.8	1.2	1.6
Major Depression (MDD)	0.7	0.8	2.6	1.6	1.1	-0.2	0.8	0.4	-0.2	-0.4	-1.1	-0.6	-1.2
Reaction Time	0.8	1.4	3.0	0.9	1.6	-0.6	-1.7	-0.9	-1.2	-1.6	-0.4	-1.2	-0.9
Verbal and Numeric Reasoning (VNR)	1.0	2.3	11.4	0.9	3.4	-0.6	-1.2	-1.5	-2.4	-0.6	0.7	-0.3	0.1
Breast Cancer	0.1	0.2	0.6	0.4	-0.8	0.4	-0.6	-0.2	0.0	-0.2	-0.3	-0.8	0.5
Ovarian Cancer	1.4	1.9	3.7	1.9	0.4	0.4	-1.4	-1.3	-0.2	-1.6	-1.8	-1.9	-1.3
Prostate Cancer	0.4	0.6	1.9	0.5	0.2	0.9	-1.3	-0.2	-1.4	-0.5	-0.5	-0.8	-0.5
Age at First Birth	0.4	0.6	1.3	-0.5	0.3	-0.8	0.7	0.1	-0.4	1.1	1.2	0.9	1.1
Bipolar Disorder (2011)	1.8	1.7	4.0	-1.0	-0.7	-1.4	1.6	0.0	1.4	1.6	0.8	1.4	2.0
Body Mass Index (BMI) (2010)	0.6	0.9	2.5	-0.9	-1.6	0.9	0.8	0.8	1.3	0.9	-0.4	0.9	-0.1
Coronary Artery Disease (CAD)	0.2	0.2	0.5	-0.3	0.7	0.3	0.5	0.2	0.1	0.5	0.6	0.2	0.7
Crohns Disease (2012)	0.3	0.5	1.1	-0.9	0.7	-1.1	0.5	0.8	0.0	0.6	0.7	0.7	0.5
Mean Putamen Volume	0.2	0.3	1.6	0.5	0.2	1.3	-0.2	0.2	-0.3	-0.2	-0.5	-0.3	-0.3
Fasting Glucose	0.8	0.9	2.1	-0.8	-1.2	-0.3	1.0	0.2	0.3	1.1	1.1	1.1	1.5
HbA1C	1.8	2.0	5.2	-1.7	-1.2	-1.0	0.7	0.7	1.6	1.7	0.9	1.6	2.3
HDL Cholesterol	1.6	2.7	4.7	1.8	0.0	1.0	-2.0	-1.7	-0.4	-2.2	-2.2	-1.9	-1.8
LDL Cholesterol	0.9	1.4	3.5	-0.3	1.1	-1.7	1.3	0.9	-1.0	1.1	1.9	0.7	0.9
Lupus	0.2	0.4	0.7	0.7	0.7	0.2	-0.4	-0.7	-0.8	-0.6	0.1	-0.8	-0.5
Neuroticism (2016)	0.4	0.6	3.1	0.1	-1.1	0.2	1.0	1.8	0.7	0.4	-0.2	-0.4	-0.1
Primary Biliary Cirrhosis	0.9	1.2	6.8	-1.1	-2.6	-0.6	1.0	0.7	0.7	0.7	0.6	0.9	0.6
Rheumatoid Arthritis	0.3	0.4	0.9	-0.6	0.6	-0.3	0.9	1.0	-0.4	0.8	0.2	0.9	-0.3
Schizophrenia (2014)	3.9	8.5	18.3	-1.9	-2.9	-1.0	4.3	3.9	3.9	2.8	1.9	2.6	2.3
Triglycerides	1.5	2.5	5.5	1.5	0.3	2.2	-1.5	-0.8	0.1	-1.7	-2.3	-1.8	-1.9
Type 2 Diabetes (T2D) (2012)	1.7	2.0	4.4	1.1	0.4	2.1	-1.9	-1.6	-0.4	-1.2	-1.9	-1.2	-1.0
Ulcerative Colitis	0.3	0.5	1.8	-0.9	-1.4	-0.3	-0.2	-0.1	0.8	0.3	0.2	0.9	0.6
Blood Eosinophil Count	0.0	0.3	1.7	-0.2	0.7	-0.2	-0.6	-0.2	-1.3	0.4	-0.3	-0.1	-0.7
Blood Platelet Count	1.5	17.5	28.3	-4.3	-3.5	1.6	5.3	4.4	5.0	5.2	1.8	4.3	4.5
Blood Red Count	1.5	14.1	36.6	1.5	-5.4	6.1	1.0	1.8	5.5	-0.3	-5.6	-1.4	-2.2
Blood White Count	0.5	3.7	12.6	1.3	3.5	-0.3	-2.0	-2.5	-1.6	-1.8	-0.6	-2.1	-1.4
Heel T-Score	0.2	1.2	2.8	1.1	1.6	1.7	-0.3	-0.2	-0.7	-0.8	-1.1	-1.1	-1.3
BMI	0.4	2.1	9.7	0.4	-3.1	1.3	-1.1	0.3	1.1	-0.3	-2.4	-0.9	-0.6
Height	0.5	10.6	29.4	2.0	3.2	-3.4	-4.2	-5.4	-5.2	-1.8	0.9	-1.6	-0.5
Waist Hip Ratio (WHR)	0.5	2.3	6.2	-1.4	0.3	-0.9	2.5	2.2	0.4	1.6	2.0	1.4	1.1
Systolic Blood Pressure	0.2	1.2	3.5	-0.0	-1.8	1.0	0.0	1.9	1.7	-0.0	-1.0	-0.4	0.3
Smoking Status	0.2	0.4	1.6	0.3	0.5	-0.8	0.8	-0.0	-1.3	0.6	0.5	-0.1	0.2
Allergy or Eczema	0.1	0.2	0.7	0.1	-0.6	-0.3	-0.2	-0.3	-0.2	0.2	-0.1	0.2	0.8
Cardiovascular Disease	1.0	3.3	8.4	-2.6	-0.9	-2.9	1.0	1.4	0.1	1.9	2.1	2.1	1.1
Hypothyroidism (self reported)	1.0	2.3	4.3	-2.1	-1.5	-0.4	1.5	2.0	0.7	1.5	1.6	2.1	0.7
Respiratory disease	0.4	0.9	1.9	1.4	-0.1	0.9	-0.9	0.3	0.3	-1.0	-1.3	-1.3	-1.0
Type 2 Diabetes (T2D) (2018)	1.7	3.1	5.9	1.9	-0.1	1.4	-1.9	-1.2	-1.1	-1.8	-2.4	-2.0	-2.4
Lung FEV1/FVC ratio	1.7	8.8	15.9	-3.3	-1.2	-1.1	4.0	3.6	2.6	3.0	2.3	4.0	3.0
Lung FVC	0.9	4.7	12.5	1.6	1.3	-0.4	-3.4	-3.5	-1.5	-2.7	-1.2	-2.4	-1.6
Neuroticism	0.1	0.2	0.6	0.4	-0.6	-0.8	-0.1	-0.1	-0.1	-0.2	-0.6	-0.3	-0.2
Chronotype (morning person)	0.6	1.4	2.8	-1.4	-1.0	-1.6	-0.1	0.0	0.6	1.4	0.7	1.7	1.6
Hair Pigment	0.0	0.5	2.1	-0.2	-1.2	1.4	-0.5	0.4	0.4	0.4	-0.8	-0.3	0.4
Tanning	0.2	2.0	4.1	-1.2	0.1	-2.0	1.4	0.7	1.2	1.5	1.5	1.6	1.9
Hand grip strength (left)	0.2	0.5	1.0	-0.8	0.0	-0.9	-0.7	0.2	-0.6	0.8	0.1	0.9	1.0
Number of treatments/medications taken	0.2	0.4	2.1	-0.6	0.4	-0.2	-0.6	-1.4	-0.5	0.4	0.2	0.1	-0.3
Average weekly spirits intake	0.3	0.4	0.7	0.4	0.6	0.8	-0.5	-0.0	0.8	-0.7	-0.7	-0.3	-0.5
Sensitivity / hurt feelings	0.2	0.3	1.3	0.3	-0.1	0.3	1.1	0.5	0.6	0.5	-0.3	0.3	0.3
Frequency of depressed mood in last 2 weeks	0.3	0.5	1.3	0.8	0.4	-0.0	-0.2	0.1	0.1	-0.8	-0.8	-1.1	-1.1
Hearing difficulty/problems: Yes	2.8	4.3	17.1	0.0	3.2	-2.7	-1.4	-1.5	-4.1	-0.4	2.0	-0.3	0.1
Relative age of first facial hair	2.1	4.3	7.5	-2.3	-0.7	-1.6	2.6	1.8	1.3	2.0	2.7	2.2	2.6
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.7	0.2	-0.5	0.2	1.3	0.2	1.3	0.3	0.1	-0.3	-0.0
Ever used hormone-replacement therapy (HRT)	0.8	1.0	2.4	-1.1	-1.0	1.0	0.9	1.6	1.2	0.7	-0.1	1.1	-0.0
Ever had hysterectomy (womb removed)	2.9	3.3	7.8	2.0	-0.0	1.9	-1.3	-0.2	-1.1	-1.9	-2.4	-2.3	-2.8
Systolic blood pressure, automated reading	0.5	1.6	4.8	-0.1	-1.6	2.2	-0.4	1.3	1.8	-0.3	-1.5	-0.6	-0.4
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	3.3	0.4	-0.3	-0.4	-1.8	-1.6	-1.5	-0.8	0.0	-1.1	-0.8
Angina	1.0	1.3	2.8	-1.5	1.3	-0.2	0.6	0.7	0.9	1.1	1.7	1.2	1.4
Medication for hormone replacement therapy	0.6	0.6	3.6	-0.7	-1.9	-0.9	-0.7	-0.1	-0.7	0.1	0.3	0.4	0.1
Vitamin and mineral supplements	1.0	1.3	3.6	0.2	-1.6	1.9	1.1	1.6	0.8	0.2	-1.2	0.1	-1.0
Supplements: Zinc	2.8	3.0	5.6	-2.0	-1.9	-2.0	1.1	1.2	0.3	2.1	1.7	1.7	2.4
Medication: Co-codamol	1.1	1.3	2.6	1.1	-0.4	1.4	-1.3	-0.2	-0.4	-1.1	-1.6	-1.4	-1.4
Medication: Metformin	2.1	3.0	5.7	1.7	1.1	1.3	-2.4	-2.4	-0.9	-1.3	-2.3	-1.6	-1.5
Diabetes (father)	0.6	0.8	5.1	0.2	-0.6	2.3	-0.4	0.2	1.0	-0.4	-0.9	-0.5	-0.1
Diabetes (mother)	0.4	0.5	1.2	-0.1	-1.0	-0.3	1.0	1.0	1.1	0.4	-0.1	0.6	0.6
Severe depression (siblings)	1.0	1.1	3.0	0.9	1.3	-0.9	-1.7	-0.6	-0.6	-1.3	-0.4	-1.3	-0.5
Pack years adult smoking proportion	0.2	0.3	1.6	0.3	-0.4	0.1	-0.0	-0.2	-0.9	-0.2	-0.6	-0.6	-1.2
Impedance of leg (right)	0.2	0.9	3.9	-0.3	2.0	-1.0	0.4	-0.5	-0.5	0.2	1.4	0.7	0.5
Leg fat-free mass (left)	0.3	1.7	4.3	1.2	-1.2	-0.2	-2.1	-1.6	-1.0	-1.1	-1.6	-1.2	-0.9
Trunk fat percentage	0.3	1.4	4.0	1.1	-0.5	0.8	-1.6	-1.4	0.1	-1.0	-2.0	-1.0	-1.0
Hand grip strength (right)	1.1	2.9	5.9	-2.2	-1.4	-1.2	0.4	1.4	-0.3	2.4	1.3	2.3	2.4
Townsend deprivation index at recruitment	3.7	5.2	10.8	2.5	0.7	1.5	-2.1	-1.7	-0.6	-2.9	-2.5	-3.2	-3.3
Current tobacco smoking	0.7	1.2	3.7	1.4	0.6	0.8	0.0	-0.4	-0.7	-1.2	-0.8	-1.6	-1.9
Average weekly fortified wine intake	0.5	0.6	2.3	-0.9	0.5	-0.5	0.3	0.2	0.1	0.5	1.2	0.8	1.5
Maternal smoking around birth	2.3	3.3	6.0	1.8	1.7	-0.1	-2.4	-1.5	-2.1	-2.1	-1.0	-2.2	-1.9
Fed-up feelings	0.1	0.2	0.5	-0.6	-0.6	-0.7	-0.2	0.4	0.7	0.1	-0.2	0.1	-0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.7	0.2	-0.7	-0.2	0.3	0.4	-0.2	0.2	-0.8	0.1	-0.7
Relative age voice broke	1.1	1.6	4.2	-1.2	-1.1	-0.1	2.1	0.8	1.2	1.7	0.8	1.6	1.3
Taking other prescription medications	0.6	1.0	1.8	0.6	0.6	0.3	-1.3	-1.2	-1.3	-0.7	-0.9	-1.1	-1.3
Age when periods started (menarche)	1.0	2.5	6.2	-1.5	0.2	-1.8	2.2	1.1	-0.6	1.6	2.5	1.7	1.0
Bilateral oophorectomy (both ovaries removed)	1.1	1.2	2.6	1.1	-0.8	1.1	-1.0	0.2	0.1	-1.2	-1.6	-1.5	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.8	2.1	0.5	1.4	1.4	-0.7	0.3	0.3	-0.8	-0.9	-1.0	-0.5
Tinnitus: Yes, but not now, but have in the past	0.9	0.9	4.8	-0.0	-2.2	1.1	0.5	0.8	1.2	0.2	-0.8	0.1	-0.5
Qualifications: CSEs or equivalent	1.7	2.3	4.1	-1.2	-1.5	-0.2	1.8	2.0	1.8	1.9	0.4	1.5	1.6
Serious illness, injury or assault to yourself	0.1	0.2	0.6	0.1	0.6	-0.8	-0.0	-0.8	-0.0	0.1	0.0	0.0	-0.2
High blood pressure	0.3	0.8	2.5	-1.6	0.2	-1.4	-0.1	0.0	-0.2	0.6	1.4	0.7	0.5
Hayfever, allergic rhinitis or eczema	0.1	0.1	0.9	-0.1	-0.1	0.0	-0.5	-0.1	-1.0	0.2	-0.0	0.1	0.5
Multivitamins +/- minerals	1.8	2.3	5.9	-0.0	2.4	-2.4	-1.6	-2.2	-0.8	-1.0	1.2	-0.1	0.6
Stomach or abdominal pain in last month	0.1	0.2	0.6	-0.1	-0.8	0.8	-0.2	-0.1	0.2	0.3	-0.3	0.0	0.4
Supplements: Glucosamine	0.5	0.7	3.1	-0.1	0.7	-0.6	-1.1	-1.3	-1.8	-0.2	0.2	0.2	0.1
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	2.5	-0.3	0.1	-0.8	-0.2	0.9	-1.6	0.1	0.7	-0.0	0.0
Medication: Atenolol	1.1	1.3	3.9	-2.0	0.5	-0.8	-0.1	0.5	-0.1	1.2	1.6	1.7	1.3
Medication: Levothyroxine sodium	1.3	2.1	3.6	-1.9	-1.3	0.0	1.6	1.1	1.7	1.6	1.4	1.7	1.3
Sitting height	0.9	6.6	16.3	2.6	1.7	-1.7	-4.0	-3.9	-2.9	-2.7	-0.8	-2.1	-1.1
Chronic bronchitis/emphysema (father)	0.4	0.5	1.2	-1.1	-1.0	-0.2	-0.4	1.0	-0.3	0.5	0.8	0.3	0.4
High blood pressure (mother)	0.2	0.3	1.0	-0.2	-0.2	0.6	0.1	0.5	1.0	0.5	-0.6	0.4	0.5
Body mass index (BMI)	0.3	1.5	5.4	0.3	-2.3	1.4	-0.6	0.2	1.0	-0.2	-2.3	-0.6	-0.7
Impedance of leg (left)	0.1	0.6	3.3	0.0	1.8	-0.7	0.2	-0.8	-0.5	0.0	1.1	0.6	0.3
Leg predicted mass (left)	0.3	1.8	4.7	1.3	-1.1	-0.2	-2.2	-1.6	-1.0	-1.1	-1.7	-1.3	-0.9
Trunk fat mass	0.4	1.7	4.4	1.2	-0.8	0.5	-1.9	-1.6	-0.3	-1.1	-2.1	-1.1	-1.1
Waist circumference	0.2	0.8	3.3	0.6	-1.8	0.7	-0.4	0.0	0.6	-0.3	-1.6	-0.6	-0.6
Number of incorrect matches in round	2.2	3.7	7.4	2.3	0.9	-0.3	-2.2	-2.1	-2.7	-2.1	-1.2	-2.2	-1.8
Past tobacco smoking	0.5	0.9	1.9	0.5	0.8	1.4	-0.8	-0.7	0.5	-1.3	-1.0	-0.8	-1.3
Alcohol usually taken with meals	0.6	0.9	2.0	-1.1	-1.4	-0.9	0.1	0.9	1.1	0.5	0.2	1.2	1.2
Nervous feelings	0.4	0.7	1.5	-0.7	-0.7	-1.0	0.7	0.4	0.7	0.7	1.0	0.7	1.2
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	3.2	0.1	0.3	-1.8	-0.8	-0.5	-0.7	-0.4	0.5	-0.6	0.4
Hearing difficulty/problems with background noise	2.8	4.4	21.3	-0.0	2.4	-2.9	-2.1	-1.1	-4.6	-0.7	1.5	-0.5	-0.5
Hair/balding pattern: Pattern 2	0.4	0.5	2.8	-0.0	1.3	-0.1	0.3	-0.6	1.7	-0.2	0.2	0.1	0.5
Had menopause	1.8	2.3	7.5	-1.2	-1.5	-0.0	2.1	2.7	1.6	1.1	1.0	1.4	0.3
Had other major operations	1.0	1.2	4.7	0.3	-0.6	1.1	-1.0	-0.6	-1.1	-1.1	-0.7	-0.9	-2.2
Forced vital capacity (FVC)	2.1	8.2	24.9	2.4	2.2	-1.8	-4.3	-5.0	-2.9	-2.9	-0.6	-2.4	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.3	0.7	0.6	0.9	-0.2	0.6	0.6	-0.6	-1.1	-0.9	-0.9
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	1.1	0.3	-0.9	0.2	-0.0	1.0	0.6	-0.4	-0.6	-0.7	-0.4
Qualifications: None of the above	0.9	1.9	4.8	-0.4	-2.2	2.1	1.2	1.4	2.1	0.7	-1.2	-0.0	-0.5
Financial difficulties in last 2 years	2.6	3.6	14.0	1.4	-1.6	3.7	0.2	0.5	1.5	-0.5	-3.2	-1.1	-1.6
Mouth/teeth dental problems	0.4	0.5	1.3	-0.7	0.4	0.1	0.8	1.1	-0.1	0.8	0.6	1.0	0.9
Heart attack	0.5	0.7	1.9	-1.4	-0.1	-1.2	0.1	0.0	0.3	0.7	1.3	0.8	0.6
Allergy	0.2	0.4	1.4	-0.5	0.2	-1.2	0.8	-0.2	0.4	0.6	0.8	0.8	0.4
Pain all over the body in last month	0.6	0.6	2.1	0.3	-0.1	1.5	-1.1	-0.6	0.7	-0.8	-1.0	-0.6	-0.4
Diabetes (self-reported)	2.4	3.7	5.9	2.3	0.3	0.3	-2.4	-2.0	-1.2	-2.2	-2.3	-2.2	-2.3
Hayfever/allergic rhinitis (self-reported)	1.5	2.0	4.0	-1.4	-0.3	-1.1	1.7	1.3	0.2	1.9	2.0	1.4	1.7
Medication: Ramipril	1.4	1.8	3.6	-1.9	-1.7	-0.6	0.9	1.6	0.5	1.5	1.3	1.6	1.1
Medication: Simvastatin	0.2	0.3	0.7	-0.8	0.5	-0.9	0.2	-0.1	-0.5	0.5	0.4	0.6	-0.2
Fluid intelligence score	1.2	2.4	8.4	0.8	2.9	-0.9	-1.8	-1.5	-2.7	-0.9	0.7	-0.5	0.2
Illnesses of siblings	0.7	1.0	2.3	0.7	0.5	1.5	-1.1	-1.4	0.4	-0.8	-1.5	-0.6	-1.0
Neuroticism score	0.1	0.1	0.4	0.4	-0.1	-0.7	-0.3	-0.1	-0.5	-0.3	-0.2	-0.5	-0.0
Weight	0.3	1.4	4.0	1.0	-1.4	0.5	-1.7	-1.4	-0.3	-0.7	-2.0	-1.0	-0.9
Impedance of arm (right)	0.6	2.6	13.7	0.2	3.7	-1.3	-0.4	-1.6	-1.7	-0.4	2.2	0.2	0.8
Arm fat percentage (right)	0.3	1.2	3.9	1.0	-0.6	1.1	-1.3	-0.9	0.2	-0.9	-2.0	-1.1	-1.0
Trunk fat-free mass	0.3	1.5	3.4	1.2	-1.2	0.1	-1.9	-1.6	-0.9	-0.9	-1.6	-1.1	-1.0
Hip circumference	0.5	2.3	6.0	1.4	-1.9	1.1	-1.9	-1.6	-0.1	-1.1	-2.5	-1.4	-1.2
Time employed in main current job	0.5	0.6	1.1	-1.0	-0.9	-0.9	0.3	-0.5	-0.2	0.9	0.9	0.7	0.8
Alcohol intake versus 10 years previously	1.8	2.8	9.1	1.3	-1.1	3.0	-0.3	-1.3	0.6	-0.8	-2.5	-1.3	-2.2
Father’s age at death	0.1	0.1	0.4	0.6	0.2	0.1	0.4	0.5	-0.4	-0.4	0.1	0.1	-0.3
Worrier / anxious feelings	0.0	0.1	0.4	0.0	0.0	-0.6	-0.1	-0.2	0.1	0.0	-0.3	0.1	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	2.9	1.1	-0.4	0.4	-1.1	-0.3	-0.3	-1.5	-1.1	-1.7	-1.4
Falls in the last year	1.0	1.4	3.8	1.0	0.3	2.0	-1.2	-0.6	-0.4	-0.7	-1.9	-1.0	-1.2
Hair/balding pattern: Pattern 3	1.1	1.6	3.7	-1.7	-1.1	0.3	1.5	1.9	0.7	1.3	1.0	1.5	0.5
Number of live births	0.2	0.3	1.3	-0.0	-1.2	-0.4	0.3	0.8	0.6	-0.2	-0.0	-0.2	-0.5
Forced expiratory volume in 1-second (FEV1)	0.9	3.0	10.9	1.3	1.2	-1.4	-2.6	-3.3	-1.6	-1.8	-0.4	-1.1	-0.3
Pulse rate	0.1	0.1	0.4	-0.1	-0.4	-0.6	0.1	-0.1	0.5	0.1	0.1	0.6	0.3
Happiness	1.3	1.5	4.0	1.2	1.5	-2.0	-1.2	-0.6	-1.6	-1.0	0.9	-1.2	0.6
Noisy workplace	0.5	0.6	1.2	0.7	-1.0	0.4	-0.8	0.1	-0.2	-0.7	-0.9	-1.1	-1.1
Qualifications: A levels/AS levels or equivalent	0.7	1.6	4.3	-1.0	-0.7	-1.9	0.4	0.7	-0.8	0.9	1.8	1.1	2.1
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.6	3.2	1.8	-0.4	1.4	-1.2	-0.7	0.1	-1.7	-1.7	-1.6	-1.0
Mouth/teeth dental problems: Dentures	0.3	0.5	1.0	0.1	-0.8	-1.0	0.9	-0.7	-1.0	0.3	0.4	-0.3	-1.0
Asthma	0.3	0.6	1.4	0.8	0.8	1.1	-0.6	0.2	-0.5	-0.5	-0.7	-1.2	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.0	0.6	-0.0	0.8	-0.3	-0.6	0.7	-0.5	-1.0	-0.6	-0.6
Medication: Cholesterol lowering	0.7	1.0	3.3	-0.2	0.7	-1.8	-1.6	-1.4	-1.2	-0.5	0.4	-0.2	-0.4
Depression (self-reported)	1.4	1.7	2.9	1.5	0.6	-0.2	-1.4	-1.6	-0.5	-1.4	-1.5	-1.4	-1.7
Medication: Lansoprazole	1.3	1.5	3.6	0.7	1.4	0.3	-1.5	-1.2	-1.9	-0.7	-0.8	-1.4	-1.4
Prospective memory result	0.6	0.7	4.4	-0.2	-2.1	0.7	0.8	-0.4	0.3	0.1	-0.3	-0.2	-1.0
Lung cancer (father)	1.8	2.2	4.0	1.5	1.2	0.9	-1.7	-1.7	-0.8	-1.6	-1.5	-2.0	-1.4
Illnesses of mother	0.3	0.3	2.3	0.1	-1.5	0.7	-0.1	-0.1	0.6	0.1	-0.3	-0.2	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.1	9.9	1.4	2.1	-1.9	-2.9	-3.1	-2.9	-1.9	0.0	-1.1	-0.3
Pulse wave Arterial Stiffness index	0.4	0.4	1.7	-0.6	0.3	-0.5	0.3	0.4	-0.5	0.7	1.3	0.4	0.9
Impedance of arm (left)	0.5	2.1	11.3	0.4	3.4	-1.1	-0.4	-1.8	-1.1	-0.6	1.8	0.1	0.6
Arm fat mass (right)	0.5	2.0	6.2	1.3	-1.0	1.1	-1.8	-1.3	-0.0	-1.2	-2.5	-1.4	-1.4
Trunk predicted mass	0.3	1.5	3.4	1.2	-1.2	0.1	-1.8	-1.6	-1.0	-0.9	-1.6	-1.1	-0.9
Standing height	0.4	4.2	14.3	1.6	1.9	-1.7	-2.7	-3.8	-3.0	-1.4	0.2	-0.8	-0.6
Length of working week for main job	6.0	6.6	10.1	2.8	1.5	1.8	-3.2	-2.9	-2.3	-2.9	-2.8	-2.7	-2.5
Exposure to tobacco smoke at home	0.5	0.5	2.5	-0.2	-1.6	1.0	0.4	0.1	0.9	0.7	-0.2	-0.0	0.4
Breastfed as a baby	0.6	0.8	3.4	-0.3	1.9	-0.9	0.1	-0.7	-0.5	0.0	1.4	0.4	0.7
Tense / ‘highly strung’	0.5	0.8	2.2	-0.8	0.8	-1.5	-0.8	-0.6	-1.3	0.3	1.2	0.2	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	4.4	-0.6	0.8	-2.1	0.6	0.6	-0.5	0.3	1.9	0.3	0.9
Hair/balding pattern: Pattern 4	0.1	0.2	0.9	0.2	-0.4	0.1	0.2	0.5	0.1	0.4	-1.0	0.4	-0.1
Birth weight of first child	0.4	0.7	3.0	-0.2	1.7	-0.8	-0.2	-0.7	-1.3	0.2	0.8	0.2	0.3
Peak expiratory flow (PEF)	0.3	0.8	2.3	0.4	-0.1	-0.8	-1.5	-1.5	-1.5	-0.6	0.1	-0.3	0.2
Pulse wave reflection index	1.3	1.6	3.0	-1.1	0.2	-0.8	1.6	0.9	0.6	1.7	1.6	1.2	1.7
Ever highly irritable/argumentative for 2 days	0.2	0.3	1.0	0.2	0.4	-0.6	-0.8	0.0	-1.0	-0.4	0.3	-0.5	0.4
Loud music exposure frequency	0.5	0.5	2.5	0.4	0.5	-1.6	0.3	-0.1	-0.3	0.4	1.0	0.1	1.0
Qualifications: O levels/GCSEs or equivalent	1.6	2.6	5.0	-1.1	-1.4	-2.1	1.8	1.3	-0.7	1.2	2.2	1.9	1.8
Mouth/teeth dental problems: Bleeding gums	0.7	0.8	4.9	-0.6	-0.5	0.6	0.4	1.2	2.2	0.2	-0.4	0.5	0.7
Blood clot in the leg (DVT)	0.9	1.1	5.9	0.7	-0.3	2.4	0.2	0.5	-0.1	-0.4	-1.4	-0.8	-1.4
Medication: Paracetamol	0.9	1.5	3.2	-1.8	-1.7	0.1	0.8	0.1	-1.4	1.7	1.4	1.0	0.9
Headache pain in last month	0.5	0.9	3.4	-1.2	-0.7	-1.8	0.0	-0.5	0.5	0.9	1.2	0.5	0.9
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	3.8	1.0	0.4	2.0	0.2	0.4	0.7	-0.6	-1.0	-0.7	-0.0
Glaucoma (self-reported)	2.4	2.8	7.4	1.5	1.4	0.1	-2.7	-2.3	-1.7	-1.7	-1.1	-1.7	-1.0
Gout (self-reported)	1.4	1.9	3.8	1.7	1.0	0.7	-1.5	-1.8	-1.5	-1.5	-0.6	-1.9	-1.1
Hypothyroidism/myxoedema (self-reported)	1.2	2.3	3.9	-2.0	-1.8	-0.3	1.5	1.6	1.2	1.6	1.4	1.9	1.0
Medication: Amlodipine	0.2	0.2	1.3	-0.3	-0.5	0.2	-1.1	-0.7	-0.4	0.0	-0.3	-0.2	-0.0
Medication: Ventolin 100micrograms inhaler	0.9	1.2	3.8	1.5	-0.3	1.9	-0.1	0.3	-0.3	-0.8	-1.2	-1.3	-1.3
Birth weight	0.8	1.7	3.9	-1.1	-0.6	-1.4	2.0	0.9	0.7	1.4	1.5	1.5	1.2
Chronic bronchitis/emphysema (mother)	0.5	0.6	2.2	-0.8	-0.3	-0.4	0.7	1.1	1.5	0.3	0.4	0.8	0.2
High blood pressure (siblings)	0.5	0.8	2.8	-0.2	1.1	-1.1	-0.3	0.1	-1.7	-0.1	1.3	0.2	0.6
Forced vital capacity (FVC), Best measure	2.2	8.0	19.6	2.0	2.6	-2.7	-4.0	-4.4	-3.8	-2.6	-0.0	-1.9	-1.0
Body fat percentage	0.3	1.1	3.8	0.8	-1.0	0.8	-1.3	-0.9	0.3	-0.7	-1.9	-0.8	-0.9
Leg fat percentage (right)	0.2	0.6	3.2	0.0	-1.8	0.2	-0.7	-0.2	0.3	0.1	-1.4	-0.2	-0.4
Arm fat-free mass (right)	0.3	1.4	3.7	0.9	-1.9	0.2	-1.5	-1.0	-0.3	-0.6	-1.9	-0.9	-1.0
Exposure to tobacco smoke outside home	0.6	0.7	2.4	0.7	-0.3	1.1	-0.1	-0.2	-0.3	-0.7	-1.5	-0.6	-1.5
Comparative body size at age 10	0.6	1.6	5.0	0.5	0.6	1.0	-2.2	-1.0	-1.5	-1.2	-1.2	-1.1	-1.3
Number of full brothers	0.3	0.4	1.6	0.2	0.5	-0.7	-0.5	-0.6	-1.3	-0.1	0.2	-0.5	-0.8
Worry too long after embarrassment	0.7	1.1	2.2	1.3	0.1	1.2	-0.7	-0.2	-0.7	-1.5	-1.4	-1.0	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.0	0.7	-0.4	-1.0	0.0	-0.3	1.0	-0.8	-0.0	-0.7	-0.3
Wheeze or whistling in the chest in last year	0.1	0.2	0.5	-0.5	0.2	-0.2	-0.5	0.2	-0.6	0.3	0.5	-0.0	0.7
Number of children fathered	0.3	0.4	1.2	0.5	-0.8	-0.0	-1.1	-0.4	-0.0	-0.5	-1.1	-0.2	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.5	-0.5	0.3	0.0	1.0	0.1	-0.1	1.1	0.8	0.9	1.2
Age at first live birth	0.3	0.5	1.2	-0.5	1.1	-0.3	0.2	-0.7	-0.4	0.6	1.1	0.7	1.0
Pulse wave peak to peak time	0.4	0.5	1.4	0.8	0.0	0.4	-0.5	-0.7	0.2	-0.8	-1.2	-0.6	-0.9
Health satisfaction	0.4	0.5	2.4	-0.0	-1.5	-0.4	0.2	0.8	1.2	-0.1	-0.3	0.0	0.3
Shortness of breath walking on level ground	0.6	0.7	1.6	-1.3	-0.8	-0.4	0.8	0.6	-0.3	1.0	1.0	1.0	0.5
Qualifications: College or University degree	1.3	4.0	9.1	1.5	2.5	-2.5	-2.5	-2.2	-3.0	-1.7	1.1	-1.2	0.6
Eye problems/disorders: None of the above	0.4	0.4	1.3	-0.5	0.4	-1.1	0.8	0.6	0.1	0.4	0.9	0.5	0.5
Mouth/teeth dental problems: Loose teeth	0.5	0.6	3.8	0.3	1.0	0.8	0.4	-0.2	1.9	-0.3	-0.5	-0.4	-0.4
Emphysema/chronic bronchitis	1.4	1.6	5.4	0.5	-1.9	2.3	0.4	1.4	1.2	-0.4	-1.3	-0.8	-1.0
Medication for pain relief, constipation, heartburn	0.3	0.6	4.2	0.9	2.0	-0.1	0.0	-0.1	-0.0	-0.5	0.2	-0.2	0.6
Neck or shoulder pain in last month	0.5	0.7	4.7	-0.1	-2.2	1.1	0.3	0.8	0.6	0.1	-0.3	-0.5	-0.3
Medication: Blood pressure	0.4	0.6	1.5	-1.2	-0.9	-1.0	-0.1	-0.1	-0.9	0.9	0.8	0.8	-0.2
Angina (self-reported)	0.6	0.8	1.8	-1.1	1.4	-0.0	0.3	0.4	0.9	0.8	1.2	0.8	1.1
Migraine (self-reported)	1.0	1.2	4.8	-1.3	-0.4	-2.2	-0.2	0.1	0.3	0.5	1.5	0.8	1.4
Medication: Ibuprofen	0.2	0.2	1.2	0.4	0.2	0.7	0.0	-0.2	1.1	-0.1	-0.6	-0.3	0.1
Medication: Allopurinol	1.7	2.2	4.8	2.0	0.5	1.2	-1.1	-1.4	-1.2	-1.5	-1.4	-2.2	-1.7
Medication: Omeprazole	0.4	0.5	1.7	-0.8	-1.3	-0.0	-0.0	0.8	1.0	0.3	-0.5	0.8	-0.5
Medication: Seretide 50 evohaler	1.1	1.3	3.3	1.4	0.6	-0.7	-1.8	-1.5	-0.3	-1.4	-0.7	-1.3	-0.4
Mean time to correctly identify matches	0.3	0.5	1.4	0.1	1.1	-0.9	-0.7	0.0	-1.2	-0.7	0.4	-0.5	-0.8
Heart disease (mother)	0.9	1.1	4.2	0.1	1.1	-1.8	-0.4	-0.4	-2.0	-0.4	1.3	-0.3	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	2.5	-0.9	-0.6	-1.0	-0.0	0.5	-0.9	0.6	1.6	1.0	1.6
Whole body fat mass	0.4	1.5	5.0	1.1	-1.4	0.8	-1.6	-1.1	0.1	-0.8	-2.2	-1.0	-1.0
Leg fat mass (right)	0.2	0.8	2.9	0.4	-1.7	0.1	-1.0	-0.6	0.0	-0.1	-1.6	-0.4	-0.5
Arm predicted mass (right)	0.3	1.4	4.2	0.9	-2.1	0.1	-1.5	-0.8	-0.3	-0.7	-2.0	-0.9	-1.1
Pulse rate, automated reading	0.2	0.5	1.2	0.8	-0.1	-1.0	-1.1	-0.8	0.4	-1.0	-0.4	-0.6	0.1
Alcohol intake frequency.	1.6	3.6	9.2	-0.4	-2.9	3.0	2.1	1.6	2.5	0.8	-1.7	0.3	-1.3
Comparative height size at age 10	0.6	3.4	7.5	2.2	2.2	-0.1	-2.2	-2.7	-2.0	-1.7	-0.9	-1.8	-1.4
Number of full sisters	0.4	0.5	1.0	0.9	0.4	-0.4	-0.5	-0.9	-1.0	-0.8	-0.0	-0.7	-0.6
Suffer from ‘nerves’	1.0	1.6	4.3	-0.7	1.2	-1.9	1.0	-0.1	-0.5	1.1	2.1	0.5	1.8
Overall health rating	0.1	0.2	1.3	-0.6	-1.1	-0.4	-0.1	0.2	-0.3	0.3	0.1	0.2	-0.4
Chest pain or discomfort	0.2	0.3	1.1	-0.7	-0.3	0.1	0.3	0.5	1.0	0.4	0.3	0.3	0.5
Had major operations	0.6	0.7	1.6	0.6	1.2	0.2	-0.5	-1.3	-0.9	-0.8	-0.2	-0.9	-1.0
Age at last live birth	0.1	0.2	0.9	0.2	0.6	0.6	0.2	-0.9	-0.4	-0.0	0.3	-0.1	0.1
Family relationship satisfaction	0.8	1.0	3.0	0.4	1.2	-1.7	-0.7	-0.5	-1.4	-0.8	1.1	-0.4	0.5
Leg pain on walking	0.4	0.5	3.0	-0.2	-1.7	-0.5	0.7	0.8	0.2	0.7	-0.0	0.0	-0.2
Qualifications: NVQ or HND or HNC or equivalent	2.8	3.4	5.3	-1.9	-2.3	-0.0	2.2	2.0	1.9	2.1	0.9	2.2	1.4
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.8	-0.3	0.2	-0.0	0.0	0.4	0.4	0.8	0.4	0.3	0.9
Illness, injury, bereavement, stress in last 2 years	2.0	2.5	5.8	-2.2	0.2	-2.4	-0.0	0.4	-1.0	1.5	2.3	1.7	1.6
Medication: Aspirin	0.5	0.6	2.0	-1.3	-1.4	-0.6	0.0	0.9	0.2	0.6	0.1	0.7	-0.5
Supplements: Vitamin C	0.6	0.7	2.1	-0.7	-1.3	0.4	0.0	0.5	1.1	1.1	0.4	0.3	1.5
Knee pain experienced in last month	0.2	0.3	0.7	-0.5	-0.5	0.9	-0.7	0.1	-0.2	0.7	-0.8	0.1	0.1
Hypertension (Self-reported)	0.3	0.8	2.4	-1.5	0.3	-1.6	-0.1	0.1	-0.5	0.6	1.3	0.8	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.9	2.2	5.1	-1.7	-1.1	0.1	1.6	2.3	2.1	1.6	1.0	1.4	0.9
Illnesses of father: Heart disease	1.1	1.6	4.7	-1.0	0.3	-1.6	0.5	1.3	-0.2	0.9	1.9	1.0	2.2
Illnesses of siblings: Diabetes	1.2	1.4	4.1	1.6	-0.5	0.8	0.3	0.1	0.7	-1.0	-1.7	-1.4	-2.0
Smoking status: Previous	1.3	1.9	3.8	-1.0	-1.2	-1.6	1.2	1.1	0.0	1.8	1.4	1.4	2.0
Forced expiratory volume in 1-second (FEV1), predicted	1.4	2.8	7.9	1.7	1.2	-1.0	-2.0	-2.8	-2.5	-1.5	-0.1	-1.4	-0.9
Whole body fat-free mass	0.3	1.7	3.7	1.3	-1.4	0.1	-1.9	-1.6	-0.8	-0.9	-1.9	-1.1	-1.0
Leg fat-free mass (right)	0.4	2.0	4.6	1.5	-1.1	0.2	-2.1	-1.7	-0.8	-1.2	-1.9	-1.4	-1.0
Arm fat percentage (left)	0.3	1.2	4.1	0.9	-0.9	1.0	-1.2	-0.9	0.4	-0.9	-2.0	-1.1	-0.9
Average weekly red wine intake	0.8	1.2	4.3	0.1	1.7	-0.6	-1.9	0.3	-2.1	-1.0	0.2	-0.5	0.1
Handedness (chirality/laterality): Left-handed	0.7	0.8	5.6	-0.3	0.0	-2.4	0.7	0.4	-0.2	0.7	1.1	0.5	0.4
Mood swings	0.1	0.2	0.8	0.2	0.9	-0.9	-0.4	0.2	-0.1	-0.1	0.2	-0.4	0.2
Loneliness, isolation	0.2	0.3	1.2	-0.5	-0.0	-1.1	0.8	0.2	-0.0	0.6	0.9	0.4	0.3
Long-standing illness, disability or infirmity	0.9	1.4	3.7	0.4	-1.6	1.6	0.4	0.9	1.9	-0.3	-1.3	-1.0	-1.2
Ever had bowel cancer screening	0.3	0.3	2.1	0.0	0.7	1.4	-0.0	-0.4	0.1	-0.2	-0.2	-0.4	-0.7
Diabetes diagnosed by doctor	1.8	3.0	4.9	2.0	0.1	0.7	-2.2	-1.8	-1.0	-1.9	-2.1	-2.0	-1.9
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.1	0.8	-0.1	0.4	-0.0	0.7	1.0	-0.5	-1.0	-0.6	-0.4
Friendships satisfaction	1.6	1.9	7.2	-0.6	1.5	-2.7	-0.2	0.0	-1.7	-0.0	2.2	0.7	1.2
Qualifications: nursing, teaching	0.8	1.2	4.7	-0.0	0.1	-2.2	-1.0	-0.9	-2.0	-0.4	0.9	0.1	0.5
Commuting to job workplace: Walk	0.5	0.6	1.7	-0.9	-1.3	-0.1	0.4	-0.1	-0.3	0.7	1.1	0.7	1.0
Eye problems/disorders: Cataract	0.8	0.9	2.9	-0.7	0.4	0.7	1.7	0.3	1.3	1.2	0.4	1.1	0.6
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	1.3	0.5	0.0	-0.2	-1.1	-0.2	-0.0	-1.1	-0.2	-0.8	-0.4
Medication for cholesterol	0.3	0.4	2.5	0.2	-0.2	0.6	1.0	0.3	1.6	0.4	-0.2	0.2	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.2	2.5	5.9	1.8	1.8	0.6	-2.0	-0.9	-2.4	-1.2	-1.2	-1.7	-1.3
Back pain experienced in last month	1.3	1.8	8.0	1.0	0.1	2.8	-0.6	0.2	-0.2	-0.5	-2.2	-1.3	-1.5
Mineral and other dietary supplements	0.5	0.7	3.6	0.5	-1.2	0.2	1.1	0.4	1.9	-0.2	-0.4	-0.4	-0.4
Breast cancer (self-reported)	1.3	1.5	3.6	1.3	-0.4	0.5	-1.6	-0.1	-0.2	-1.9	-1.3	-1.6	-1.6
Asthma (self-reported)	0.3	0.5	1.3	0.8	0.9	1.0	-0.7	0.2	-0.4	-0.5	-0.7	-1.1	-0.5
Osteoporosis (self-reported)	0.3	0.3	1.7	-0.1	-0.5	0.3	1.3	0.7	-0.2	0.4	0.4	0.4	0.0
Osteoarthritis (self-reported)	2.7	3.5	5.5	2.0	-0.1	1.6	-2.2	-1.0	-2.1	-1.6	-2.3	-2.1	-2.3
Medication: Aspirin	0.3	0.4	1.2	-1.1	-0.8	-0.9	-0.2	0.7	-0.3	0.3	0.2	0.5	-0.7
Medication: Gliclazide	1.0	1.1	3.2	0.8	0.2	-0.3	-1.8	-0.5	-1.2	-0.9	-1.2	-1.1	-1.3
Illnesses of father: None of the above (group 1)	1.0	1.2	2.8	1.5	0.1	0.2	-0.4	-1.3	0.1	-1.0	-1.7	-1.3	-1.5
Smoking status: Current	0.5	0.9	2.9	1.2	0.5	0.8	0.2	-0.2	-0.6	-0.9	-0.7	-1.4	-1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	3.9	-0.3	1.1	-1.2	-1.3	-1.7	-2.0	-0.1	0.6	0.2	0.9
Whole body water mass	0.3	1.7	3.7	1.2	-1.4	0.1	-1.9	-1.4	-0.8	-1.0	-1.9	-1.2	-1.1
Leg predicted mass (right)	0.4	2.0	4.7	1.4	-1.1	0.1	-2.2	-1.8	-0.9	-1.2	-1.9	-1.4	-1.0
Arm fat mass (left)	0.3	1.2	4.6	0.8	-1.4	0.8	-1.4	-0.8	0.1	-0.6	-2.2	-0.9	-0.9
Number of self-reported non-cancer illnesses	0.1	0.2	0.8	-0.2	0.9	0.6	-0.0	-0.1	0.0	0.2	-0.3	-0.3	-0.7
Average weekly champagne plus white wine intake	0.7	0.9	3.1	0.8	-0.7	0.5	-0.7	0.4	0.7	-1.1	-1.7	-0.8	-1.2
Miserableness	0.3	0.5	1.5	-0.9	-1.2	-0.8	0.7	0.8	-0.1	0.5	0.7	0.6	0.7
Guilty feelings	0.3	0.4	1.5	-0.5	-1.0	-1.2	-0.3	0.6	0.4	0.2	0.4	0.3	0.7
Wears glasses or contact lenses	0.3	0.3	1.6	-0.0	-0.6	0.6	-0.3	0.4	1.3	-0.1	-0.8	-0.2	0.1
Ever taken oral contraceptive pill	0.8	0.9	2.7	0.8	1.0	0.4	-1.3	-1.7	-0.8	-0.9	-0.7	-0.9	-0.1
Hearing aid user	1.1	1.3	2.2	0.9	0.8	-0.8	-1.1	-1.5	-1.2	-1.3	-0.5	-1.3	-1.5
Mother’s age at death	0.2	0.2	0.9	0.1	0.4	-0.9	0.4	-0.3	-0.4	-0.1	0.6	0.5	-0.5
Financial situation satisfaction	0.9	1.1	3.0	0.3	-1.1	1.7	0.2	1.2	1.4	-0.2	-1.6	-0.6	-0.7
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.6	-0.1	-0.3	-0.8	0.0	-0.2	-0.2	0.4	0.2	-0.0	0.3
Commuting to job workplace: Public transport	0.1	0.1	0.3	-0.6	-0.5	-0.2	-0.2	0.1	0.0	-0.5	0.3	0.1	-0.0
Eye problems/disorders: Glaucoma	1.5	1.7	4.8	1.2	1.1	-0.6	-2.2	-1.8	-1.6	-1.2	-0.6	-1.4	-0.5
Medication: Blood pressure	0.5	0.9	2.7	-1.1	-0.1	-1.5	-0.1	0.4	-1.1	0.5	1.6	0.6	1.0
Pain type(s) experienced in last month: Hip pain	0.9	1.1	5.7	-0.1	-0.9	-1.7	-0.8	0.5	-2.4	0.1	0.1	-0.3	-0.8
Supplements: Fish oil (including cod liver oil)	0.8	1.1	3.5	0.3	1.7	-0.4	-1.9	-0.6	-1.7	-0.9	-0.1	-0.6	-0.1
High cholesterol (Self-reported)	0.8	1.4	2.6	-1.6	-0.5	-1.0	1.5	1.2	-0.2	1.6	1.2	1.5	0.4
Medication: Bendroflumethiazide	1.0	1.5	3.1	-1.6	0.5	-1.1	0.8	0.9	-0.8	1.8	1.7	1.1	1.4
Medication: Paracetamol	1.2	1.9	3.7	-1.9	-1.7	-0.6	1.1	0.4	-0.5	1.9	1.6	1.4	1.4
Medication: Lisinopril	2.6	3.4	8.0	1.7	0.3	2.8	-1.4	-1.4	-0.9	-1.4	-2.5	-1.6	-2.7
Medication: Atorvastatin	0.1	0.2	1.0	-0.1	0.1	-1.0	-0.2	-0.4	-0.2	0.0	0.6	-0.1	-0.1
Illnesses of father: High blood pressure	0.3	0.4	1.1	-0.5	0.9	0.7	0.1	-0.4	0.5	0.6	0.5	0.4	1.1
Alcohol drinker status: Never	1.4	1.7	6.6	-0.4	-2.6	1.9	1.4	1.0	1.2	0.5	-1.1	0.1	-0.6
Ever smoked	0.3	0.5	2.3	0.2	-0.1	-1.5	0.3	0.5	-1.1	0.4	0.8	-0.1	0.4
Basal metabolic rate	0.4	2.3	5.1	1.5	-1.3	0.4	-2.2	-1.8	-0.8	-1.2	-2.3	-1.4	-1.3
Leg fat percentage (left)	0.2	0.7	3.7	0.1	-1.9	0.3	-0.7	-0.3	0.6	0.0	-1.5	-0.3	-0.4
Arm fat-free mass (left)	0.3	1.5	4.4	1.1	-1.7	0.4	-1.7	-0.9	-0.5	-0.8	-2.1	-1.0	-1.1
Number of operations (self-reported)	2.7	4.0	10.0	2.3	1.3	1.1	-1.4	-1.3	-1.4	-2.4	-1.8	-2.7	-3.2
Average weekly beer plus cider intake	0.6	0.9	5.9	-0.4	-0.3	-2.4	-0.7	-0.2	-1.0	0.1	1.1	0.3	0.5
Irritability	0.3	0.5	2.0	0.2	0.8	-1.4	-0.2	-0.3	-1.4	0.0	0.1	-0.4	-0.7
Risk taking	1.2	1.8	3.6	1.3	1.4	0.5	-1.8	-1.1	-1.9	-1.1	-1.3	-1.5	-0.9
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.5	0.7	-0.6	-0.6	-0.2	-0.1	0.2	-0.5	-0.3	-0.4	-0.6
Fractured/broken bones in last 5 years	1.9	2.4	5.0	-1.5	-2.2	-1.3	2.2	0.6	-0.4	1.9	1.5	1.8	1.0
Age started oral contraceptive pill	1.2	1.5	2.9	-1.4	-0.8	1.2	1.5	1.7	1.7	1.1	0.3	1.4	0.5
Diastolic blood pressure, automated reading	0.0	0.1	0.4	-0.2	0.2	0.3	-0.2	0.6	0.7	-0.1	-0.1	-0.2	0.3
Ever depressed for a whole week	0.5	0.6	2.0	-0.6	-0.1	-1.0	0.2	0.3	0.2	0.4	1.4	0.2	1.4
Unable to work because of sickness or disability	2.2	2.9	5.4	1.7	0.9	-0.3	-2.3	-2.0	-1.0	-1.9	-1.4	-2.2	-1.9
Commuting to job workplace: Cycle	1.0	1.2	3.3	-1.0	0.8	-1.8	-0.5	-0.0	-1.5	0.6	1.5	0.8	1.2
Myopia	0.8	1.1	2.9	1.4	-0.4	1.7	0.7	1.1	1.2	-0.3	-1.6	-0.7	-0.4
Vascular/heart problems diagnosed by doctor	0.2	0.7	2.4	1.6	-0.1	1.1	0.0	-0.4	-0.1	-0.5	-1.3	-0.6	-0.5
Cholesterol lowering medication	0.2	0.4	1.4	-0.4	0.0	0.5	0.9	1.2	0.0	0.3	-0.1	0.3	-0.8
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.7	-0.3	-0.8	0.3	-0.5	0.4	0.6	-0.2	-0.7	0.1	-0.8
Pain experienced in last month	0.5	0.8	3.7	1.2	1.9	-0.6	0.3	-0.9	-0.3	-0.9	0.1	-0.5	-0.4
Supplements: Calcium	0.7	0.8	1.8	-0.6	-1.0	0.3	1.2	1.4	0.6	1.3	0.3	0.9	0.6
Basal cell carcinoma (self-reported)	0.3	0.4	1.0	-0.7	-0.4	-0.6	-0.3	-1.0	-1.0	0.1	0.7	0.3	-0.5
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.3	-1.4	0.1	-1.5	-0.0	-0.1	0.2	0.6	1.4	0.8	0.6
Deep venous thrombosis (DVT) (self-reported)	0.8	1.1	5.4	0.5	-0.8	2.3	0.5	0.8	0.0	-0.2	-1.2	-0.6	-1.2
Heart disease (siblings)	2.3	2.8	5.2	-1.8	-2.3	-1.9	1.4	1.4	0.5	1.7	2.0	1.3	1.7
Alcohol drinker status: Previous	0.2	0.2	1.5	0.3	-0.5	0.1	0.4	0.3	1.2	0.1	-0.5	-0.1	-0.3
Pack years of smoking	0.2	0.3	1.5	0.3	-0.7	0.3	0.2	0.1	-0.8	-0.0	-0.6	-0.5	-1.2
Impedance of whole body	0.3	1.5	7.3	-0.1	2.7	-1.2	0.1	-1.2	-0.5	-0.1	1.8	0.5	0.8
Leg fat mass (left)	0.2	0.9	3.2	0.5	-1.8	0.2	-1.1	-0.7	0.2	-0.2	-1.8	-0.5	-0.6
Arm predicted mass (left)	0.2	1.1	3.3	0.6	-1.8	0.1	-1.6	-0.7	-0.4	-0.4	-1.8	-0.6	-0.8