Hub : Genes

HEATR4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.2160 0.0500 2.4e-08 0.052 0.093 0.108 0.102 0.109 5.3e-07 2.2e-11 4.2e-13 1.9e-12 3.5e-13
2 METSIM Adipose 0.1103 0.0320 4.0e-07 0.018 0.063 0.061 0.066 0.042 9.1e-04 8.5e-10 2.0e-09 3.9e-10 6.5e-07
3 NTR Blood 0.0154 0.0081 9.8e-03 0.002 0.009 0.005 0.009 0.006 4.8e-02 5.5e-04 6.2e-03 4.7e-04 5.1e-03
4 TCGA Breast Invasive Carcinoma 0.1012 0.0275 5.6e-17 0.065 0.063 0.061 NA 0.060 3.5e-13 7.4e-13 1.5e-12 NA 2.4e-12
5 TCGA Head and Neck Squamous Cell Carcinoma 0.0928 0.0387 7.3e-04 -0.001 0.001 0.003 NA 0.000 4.2e-01 2.5e-01 1.5e-01 NA 3.6e-01
6 TCGA Liver Hepatocellular Carcinoma 0.1820 0.0640 2.3e-05 0.042 0.083 0.077 NA 0.088 4.8e-03 1.0e-04 1.8e-04 NA 6.1e-05
7 TCGA Lung Adenocarcinoma 0.0801 0.0428 3.1e-03 0.001 0.000 -0.002 NA -0.001 2.3e-01 3.1e-01 9.2e-01 NA 4.7e-01
8 TCGA Ovarian Serous Cystadenocarcinoma 0.0820 0.0390 7.8e-04 0.018 0.034 0.025 NA 0.019 2.2e-02 2.3e-03 8.1e-03 NA 1.7e-02
9 TCGA Pancreatic Adenocarcinoma 0.2130 0.0760 2.4e-05 0.037 0.087 0.074 NA 0.091 1.1e-02 1.7e-04 4.9e-04 NA 1.2e-04
10 TCGA Thyroid Carcinoma 0.0630 0.0290 4.2e-04 0.005 0.017 0.007 NA 0.005 1.1e-01 7.4e-03 5.8e-02 NA 9.2e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bipolar Disorder (2018) 0.3 0.4 2.2 0.5 0.1 -1.5 0.3 -0.1 -0.8 -0.1 0.8 -0.2 0.7
Bipolar Disorder or Schizophrenia 2.2 5.4 11.5 -1.3 -2.4 -1.9 3.4 2.5 2.2 2.4 2.1 2.0 2.5
Depressed Affect (Nagel 2018) 0.5 1.0 1.7 -1.3 -0.8 -0.7 1.1 1.0 0.8 1.3 0.5 1.2 1.1
Depression (Nagel 2018) 0.2 0.4 0.8 -0.5 -0.8 -0.4 0.9 0.3 0.4 0.8 -0.1 0.9 0.3
Intelligence (Savage-Jansen 2018) 1.1 3.3 10.6 -1.0 3.3 -2.6 -0.6 -0.4 -2.1 0.9 2.3 1.2 1.6
Neuroticism (Nagel 2018) 0.3 0.7 1.7 -0.6 0.2 -1.3 1.1 0.4 0.4 0.8 0.8 0.8 1.0
Schizophrenia (2018) 4.3 8.9 18.3 -2.1 -3.2 -1.2 4.3 3.7 3.4 3.1 2.1 2.8 2.7
Schizophrenia vs Biploar Disorder 1.1 1.5 8.7 -0.5 -1.4 0.4 1.4 1.1 2.9 0.6 -0.4 0.4 0.5
Worry (Nagel 2018) 0.2 0.4 1.2 -0.4 0.7 -0.7 0.8 -0.2 0.1 0.7 0.8 0.4 1.1
Alzheimer’s Disease (in mother) 11.1 13.0 22.3 3.5 4.7 -0.2 -4.6 -3.9 -4.1 -4.0 -2.1 -3.5 -3.1
Alzheimer’s Disease (in father) 2.7 3.0 5.0 1.7 1.5 1.9 -1.8 -1.2 -0.7 -2.2 -2.0 -1.7 -1.9
Alzheimer’s Disease (including proxy) 7.3 10.6 16.3 3.3 4.0 0.7 -3.7 -3.7 -3.8 -3.7 -2.2 -3.1 -2.8
Crohns Disease (2017) 0.3 0.7 1.4 -1.0 0.7 -0.3 1.0 0.6 0.6 0.7 1.1 0.9 1.2
Irritable Bowel Disease (IBD) 0.6 1.3 3.1 -1.5 -0.1 -0.5 1.2 0.3 0.6 1.4 1.3 1.5 1.8
Ulcerative Colitis (UC) 0.5 1.0 2.5 -1.2 -0.9 -0.4 0.8 -0.1 0.5 1.3 0.8 1.2 1.6
Major Depression (MDD) 0.7 0.8 2.6 1.6 1.1 -0.2 0.8 0.4 -0.2 -0.4 -1.1 -0.6 -1.2
Reaction Time 0.8 1.4 3.0 0.9 1.6 -0.6 -1.7 -0.9 -1.2 -1.6 -0.4 -1.2 -0.9
Verbal and Numeric Reasoning (VNR) 1.0 2.3 11.4 0.9 3.4 -0.6 -1.2 -1.5 -2.4 -0.6 0.7 -0.3 0.1
Breast Cancer 0.1 0.2 0.6 0.4 -0.8 0.4 -0.6 -0.2 0.0 -0.2 -0.3 -0.8 0.5
Ovarian Cancer 1.4 1.9 3.7 1.9 0.4 0.4 -1.4 -1.3 -0.2 -1.6 -1.8 -1.9 -1.3
Prostate Cancer 0.4 0.6 1.9 0.5 0.2 0.9 -1.3 -0.2 -1.4 -0.5 -0.5 -0.8 -0.5
Age at First Birth 0.4 0.6 1.3 -0.5 0.3 -0.8 0.7 0.1 -0.4 1.1 1.2 0.9 1.1
Bipolar Disorder (2011) 1.8 1.7 4.0 -1.0 -0.7 -1.4 1.6 0.0 1.4 1.6 0.8 1.4 2.0
Body Mass Index (BMI) (2010) 0.6 0.9 2.5 -0.9 -1.6 0.9 0.8 0.8 1.3 0.9 -0.4 0.9 -0.1
Coronary Artery Disease (CAD) 0.2 0.2 0.5 -0.3 0.7 0.3 0.5 0.2 0.1 0.5 0.6 0.2 0.7
Crohns Disease (2012) 0.3 0.5 1.1 -0.9 0.7 -1.1 0.5 0.8 0.0 0.6 0.7 0.7 0.5
Mean Putamen Volume 0.2 0.3 1.6 0.5 0.2 1.3 -0.2 0.2 -0.3 -0.2 -0.5 -0.3 -0.3
Fasting Glucose 0.8 0.9 2.1 -0.8 -1.2 -0.3 1.0 0.2 0.3 1.1 1.1 1.1 1.5
HbA1C 1.8 2.0 5.2 -1.7 -1.2 -1.0 0.7 0.7 1.6 1.7 0.9 1.6 2.3
HDL Cholesterol 1.6 2.7 4.7 1.8 0.0 1.0 -2.0 -1.7 -0.4 -2.2 -2.2 -1.9 -1.8
LDL Cholesterol 0.9 1.4 3.5 -0.3 1.1 -1.7 1.3 0.9 -1.0 1.1 1.9 0.7 0.9
Lupus 0.2 0.4 0.7 0.7 0.7 0.2 -0.4 -0.7 -0.8 -0.6 0.1 -0.8 -0.5
Neuroticism (2016) 0.4 0.6 3.1 0.1 -1.1 0.2 1.0 1.8 0.7 0.4 -0.2 -0.4 -0.1
Primary Biliary Cirrhosis 0.9 1.2 6.8 -1.1 -2.6 -0.6 1.0 0.7 0.7 0.7 0.6 0.9 0.6
Rheumatoid Arthritis 0.3 0.4 0.9 -0.6 0.6 -0.3 0.9 1.0 -0.4 0.8 0.2 0.9 -0.3
Schizophrenia (2014) 3.9 8.5 18.3 -1.9 -2.9 -1.0 4.3 3.9 3.9 2.8 1.9 2.6 2.3
Triglycerides 1.5 2.5 5.5 1.5 0.3 2.2 -1.5 -0.8 0.1 -1.7 -2.3 -1.8 -1.9
Type 2 Diabetes (T2D) (2012) 1.7 2.0 4.4 1.1 0.4 2.1 -1.9 -1.6 -0.4 -1.2 -1.9 -1.2 -1.0
Ulcerative Colitis 0.3 0.5 1.8 -0.9 -1.4 -0.3 -0.2 -0.1 0.8 0.3 0.2 0.9 0.6
Blood Eosinophil Count 0.0 0.3 1.7 -0.2 0.7 -0.2 -0.6 -0.2 -1.3 0.4 -0.3 -0.1 -0.7
Blood Platelet Count 1.5 17.5 28.3 -4.3 -3.5 1.6 5.3 4.4 5.0 5.2 1.8 4.3 4.5
Blood Red Count 1.5 14.1 36.6 1.5 -5.4 6.1 1.0 1.8 5.5 -0.3 -5.6 -1.4 -2.2
Blood White Count 0.5 3.7 12.6 1.3 3.5 -0.3 -2.0 -2.5 -1.6 -1.8 -0.6 -2.1 -1.4
Heel T-Score 0.2 1.2 2.8 1.1 1.6 1.7 -0.3 -0.2 -0.7 -0.8 -1.1 -1.1 -1.3
BMI 0.4 2.1 9.7 0.4 -3.1 1.3 -1.1 0.3 1.1 -0.3 -2.4 -0.9 -0.6
Height 0.5 10.6 29.4 2.0 3.2 -3.4 -4.2 -5.4 -5.2 -1.8 0.9 -1.6 -0.5
Waist Hip Ratio (WHR) 0.5 2.3 6.2 -1.4 0.3 -0.9 2.5 2.2 0.4 1.6 2.0 1.4 1.1
Systolic Blood Pressure 0.2 1.2 3.5 -0.0 -1.8 1.0 0.0 1.9 1.7 -0.0 -1.0 -0.4 0.3
Smoking Status 0.2 0.4 1.6 0.3 0.5 -0.8 0.8 -0.0 -1.3 0.6 0.5 -0.1 0.2
Allergy or Eczema 0.1 0.2 0.7 0.1 -0.6 -0.3 -0.2 -0.3 -0.2 0.2 -0.1 0.2 0.8
Cardiovascular Disease 1.0 3.3 8.4 -2.6 -0.9 -2.9 1.0 1.4 0.1 1.9 2.1 2.1 1.1
Hypothyroidism (self reported) 1.0 2.3 4.3 -2.1 -1.5 -0.4 1.5 2.0 0.7 1.5 1.6 2.1 0.7
Respiratory disease 0.4 0.9 1.9 1.4 -0.1 0.9 -0.9 0.3 0.3 -1.0 -1.3 -1.3 -1.0
Type 2 Diabetes (T2D) (2018) 1.7 3.1 5.9 1.9 -0.1 1.4 -1.9 -1.2 -1.1 -1.8 -2.4 -2.0 -2.4
Lung FEV1/FVC ratio 1.7 8.8 15.9 -3.3 -1.2 -1.1 4.0 3.6 2.6 3.0 2.3 4.0 3.0
Lung FVC 0.9 4.7 12.5 1.6 1.3 -0.4 -3.4 -3.5 -1.5 -2.7 -1.2 -2.4 -1.6
Neuroticism 0.1 0.2 0.6 0.4 -0.6 -0.8 -0.1 -0.1 -0.1 -0.2 -0.6 -0.3 -0.2
Chronotype (morning person) 0.6 1.4 2.8 -1.4 -1.0 -1.6 -0.1 0.0 0.6 1.4 0.7 1.7 1.6
Hair Pigment 0.0 0.5 2.1 -0.2 -1.2 1.4 -0.5 0.4 0.4 0.4 -0.8 -0.3 0.4
Tanning 0.2 2.0 4.1 -1.2 0.1 -2.0 1.4 0.7 1.2 1.5 1.5 1.6 1.9
Hand grip strength (left) 0.2 0.5 1.0 -0.8 0.0 -0.9 -0.7 0.2 -0.6 0.8 0.1 0.9 1.0
Number of treatments/medications taken 0.2 0.4 2.1 -0.6 0.4 -0.2 -0.6 -1.4 -0.5 0.4 0.2 0.1 -0.3
Average weekly spirits intake 0.3 0.4 0.7 0.4 0.6 0.8 -0.5 -0.0 0.8 -0.7 -0.7 -0.3 -0.5
Sensitivity / hurt feelings 0.2 0.3 1.3 0.3 -0.1 0.3 1.1 0.5 0.6 0.5 -0.3 0.3 0.3
Frequency of depressed mood in last 2 weeks 0.3 0.5 1.3 0.8 0.4 -0.0 -0.2 0.1 0.1 -0.8 -0.8 -1.1 -1.1
Hearing difficulty/problems: Yes 2.8 4.3 17.1 0.0 3.2 -2.7 -1.4 -1.5 -4.1 -0.4 2.0 -0.3 0.1
Relative age of first facial hair 2.1 4.3 7.5 -2.3 -0.7 -1.6 2.6 1.8 1.3 2.0 2.7 2.2 2.6
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 1.7 0.2 -0.5 0.2 1.3 0.2 1.3 0.3 0.1 -0.3 -0.0
Ever used hormone-replacement therapy (HRT) 0.8 1.0 2.4 -1.1 -1.0 1.0 0.9 1.6 1.2 0.7 -0.1 1.1 -0.0
Ever had hysterectomy (womb removed) 2.9 3.3 7.8 2.0 -0.0 1.9 -1.3 -0.2 -1.1 -1.9 -2.4 -2.3 -2.8
Systolic blood pressure, automated reading 0.5 1.6 4.8 -0.1 -1.6 2.2 -0.4 1.3 1.8 -0.3 -1.5 -0.6 -0.4
Eye problems/disorders: Diabetes related eye disease 1.0 1.1 3.3 0.4 -0.3 -0.4 -1.8 -1.6 -1.5 -0.8 0.0 -1.1 -0.8
Angina 1.0 1.3 2.8 -1.5 1.3 -0.2 0.6 0.7 0.9 1.1 1.7 1.2 1.4
Medication for hormone replacement therapy 0.6 0.6 3.6 -0.7 -1.9 -0.9 -0.7 -0.1 -0.7 0.1 0.3 0.4 0.1
Vitamin and mineral supplements 1.0 1.3 3.6 0.2 -1.6 1.9 1.1 1.6 0.8 0.2 -1.2 0.1 -1.0
Supplements: Zinc 2.8 3.0 5.6 -2.0 -1.9 -2.0 1.1 1.2 0.3 2.1 1.7 1.7 2.4
Medication: Co-codamol 1.1 1.3 2.6 1.1 -0.4 1.4 -1.3 -0.2 -0.4 -1.1 -1.6 -1.4 -1.4
Medication: Metformin 2.1 3.0 5.7 1.7 1.1 1.3 -2.4 -2.4 -0.9 -1.3 -2.3 -1.6 -1.5
Diabetes (father) 0.6 0.8 5.1 0.2 -0.6 2.3 -0.4 0.2 1.0 -0.4 -0.9 -0.5 -0.1
Diabetes (mother) 0.4 0.5 1.2 -0.1 -1.0 -0.3 1.0 1.0 1.1 0.4 -0.1 0.6 0.6
Severe depression (siblings) 1.0 1.1 3.0 0.9 1.3 -0.9 -1.7 -0.6 -0.6 -1.3 -0.4 -1.3 -0.5
Pack years adult smoking proportion 0.2 0.3 1.6 0.3 -0.4 0.1 -0.0 -0.2 -0.9 -0.2 -0.6 -0.6 -1.2
Impedance of leg (right) 0.2 0.9 3.9 -0.3 2.0 -1.0 0.4 -0.5 -0.5 0.2 1.4 0.7 0.5
Leg fat-free mass (left) 0.3 1.7 4.3 1.2 -1.2 -0.2 -2.1 -1.6 -1.0 -1.1 -1.6 -1.2 -0.9
Trunk fat percentage 0.3 1.4 4.0 1.1 -0.5 0.8 -1.6 -1.4 0.1 -1.0 -2.0 -1.0 -1.0
Hand grip strength (right) 1.1 2.9 5.9 -2.2 -1.4 -1.2 0.4 1.4 -0.3 2.4 1.3 2.3 2.4
Townsend deprivation index at recruitment 3.7 5.2 10.8 2.5 0.7 1.5 -2.1 -1.7 -0.6 -2.9 -2.5 -3.2 -3.3
Current tobacco smoking 0.7 1.2 3.7 1.4 0.6 0.8 0.0 -0.4 -0.7 -1.2 -0.8 -1.6 -1.9
Average weekly fortified wine intake 0.5 0.6 2.3 -0.9 0.5 -0.5 0.3 0.2 0.1 0.5 1.2 0.8 1.5
Maternal smoking around birth 2.3 3.3 6.0 1.8 1.7 -0.1 -2.4 -1.5 -2.1 -2.1 -1.0 -2.2 -1.9
Fed-up feelings 0.1 0.2 0.5 -0.6 -0.6 -0.7 -0.2 0.4 0.7 0.1 -0.2 0.1 -0.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.2 0.7 0.2 -0.7 -0.2 0.3 0.4 -0.2 0.2 -0.8 0.1 -0.7
Relative age voice broke 1.1 1.6 4.2 -1.2 -1.1 -0.1 2.1 0.8 1.2 1.7 0.8 1.6 1.3
Taking other prescription medications 0.6 1.0 1.8 0.6 0.6 0.3 -1.3 -1.2 -1.3 -0.7 -0.9 -1.1 -1.3
Age when periods started (menarche) 1.0 2.5 6.2 -1.5 0.2 -1.8 2.2 1.1 -0.6 1.6 2.5 1.7 1.0
Bilateral oophorectomy (both ovaries removed) 1.1 1.2 2.6 1.1 -0.8 1.1 -1.0 0.2 0.1 -1.2 -1.6 -1.5 -1.3
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.8 2.1 0.5 1.4 1.4 -0.7 0.3 0.3 -0.8 -0.9 -1.0 -0.5
Tinnitus: Yes, but not now, but have in the past 0.9 0.9 4.8 -0.0 -2.2 1.1 0.5 0.8 1.2 0.2 -0.8 0.1 -0.5
Qualifications: CSEs or equivalent 1.7 2.3 4.1 -1.2 -1.5 -0.2 1.8 2.0 1.8 1.9 0.4 1.5 1.6
Serious illness, injury or assault to yourself 0.1 0.2 0.6 0.1 0.6 -0.8 -0.0 -0.8 -0.0 0.1 0.0 0.0 -0.2
High blood pressure 0.3 0.8 2.5 -1.6 0.2 -1.4 -0.1 0.0 -0.2 0.6 1.4 0.7 0.5
Hayfever, allergic rhinitis or eczema 0.1 0.1 0.9 -0.1 -0.1 0.0 -0.5 -0.1 -1.0 0.2 -0.0 0.1 0.5
Multivitamins +/- minerals 1.8 2.3 5.9 -0.0 2.4 -2.4 -1.6 -2.2 -0.8 -1.0 1.2 -0.1 0.6
Stomach or abdominal pain in last month 0.1 0.2 0.6 -0.1 -0.8 0.8 -0.2 -0.1 0.2 0.3 -0.3 0.0 0.4
Supplements: Glucosamine 0.5 0.7 3.1 -0.1 0.7 -0.6 -1.1 -1.3 -1.8 -0.2 0.2 0.2 0.1
Diverticular disease/diverticulitis (self-reported) 0.4 0.4 2.5 -0.3 0.1 -0.8 -0.2 0.9 -1.6 0.1 0.7 -0.0 0.0
Medication: Atenolol 1.1 1.3 3.9 -2.0 0.5 -0.8 -0.1 0.5 -0.1 1.2 1.6 1.7 1.3
Medication: Levothyroxine sodium 1.3 2.1 3.6 -1.9 -1.3 0.0 1.6 1.1 1.7 1.6 1.4 1.7 1.3
Sitting height 0.9 6.6 16.3 2.6 1.7 -1.7 -4.0 -3.9 -2.9 -2.7 -0.8 -2.1 -1.1
Chronic bronchitis/emphysema (father) 0.4 0.5 1.2 -1.1 -1.0 -0.2 -0.4 1.0 -0.3 0.5 0.8 0.3 0.4
High blood pressure (mother) 0.2 0.3 1.0 -0.2 -0.2 0.6 0.1 0.5 1.0 0.5 -0.6 0.4 0.5
Body mass index (BMI) 0.3 1.5 5.4 0.3 -2.3 1.4 -0.6 0.2 1.0 -0.2 -2.3 -0.6 -0.7
Impedance of leg (left) 0.1 0.6 3.3 0.0 1.8 -0.7 0.2 -0.8 -0.5 0.0 1.1 0.6 0.3
Leg predicted mass (left) 0.3 1.8 4.7 1.3 -1.1 -0.2 -2.2 -1.6 -1.0 -1.1 -1.7 -1.3 -0.9
Trunk fat mass 0.4 1.7 4.4 1.2 -0.8 0.5 -1.9 -1.6 -0.3 -1.1 -2.1 -1.1 -1.1
Waist circumference 0.2 0.8 3.3 0.6 -1.8 0.7 -0.4 0.0 0.6 -0.3 -1.6 -0.6 -0.6
Number of incorrect matches in round 2.2 3.7 7.4 2.3 0.9 -0.3 -2.2 -2.1 -2.7 -2.1 -1.2 -2.2 -1.8
Past tobacco smoking 0.5 0.9 1.9 0.5 0.8 1.4 -0.8 -0.7 0.5 -1.3 -1.0 -0.8 -1.3
Alcohol usually taken with meals 0.6 0.9 2.0 -1.1 -1.4 -0.9 0.1 0.9 1.1 0.5 0.2 1.2 1.2
Nervous feelings 0.4 0.7 1.5 -0.7 -0.7 -1.0 0.7 0.4 0.7 0.7 1.0 0.7 1.2
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 3.2 0.1 0.3 -1.8 -0.8 -0.5 -0.7 -0.4 0.5 -0.6 0.4
Hearing difficulty/problems with background noise 2.8 4.4 21.3 -0.0 2.4 -2.9 -2.1 -1.1 -4.6 -0.7 1.5 -0.5 -0.5
Hair/balding pattern: Pattern 2 0.4 0.5 2.8 -0.0 1.3 -0.1 0.3 -0.6 1.7 -0.2 0.2 0.1 0.5
Had menopause 1.8 2.3 7.5 -1.2 -1.5 -0.0 2.1 2.7 1.6 1.1 1.0 1.4 0.3
Had other major operations 1.0 1.2 4.7 0.3 -0.6 1.1 -1.0 -0.6 -1.1 -1.1 -0.7 -0.9 -2.2
Forced vital capacity (FVC) 2.1 8.2 24.9 2.4 2.2 -1.8 -4.3 -5.0 -2.9 -2.9 -0.6 -2.4 -1.2
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.6 1.3 0.7 0.6 0.9 -0.2 0.6 0.6 -0.6 -1.1 -0.9 -0.9
Ever unenthusiastic/disinterested for a whole week 0.3 0.3 1.1 0.3 -0.9 0.2 -0.0 1.0 0.6 -0.4 -0.6 -0.7 -0.4
Qualifications: None of the above 0.9 1.9 4.8 -0.4 -2.2 2.1 1.2 1.4 2.1 0.7 -1.2 -0.0 -0.5
Financial difficulties in last 2 years 2.6 3.6 14.0 1.4 -1.6 3.7 0.2 0.5 1.5 -0.5 -3.2 -1.1 -1.6
Mouth/teeth dental problems 0.4 0.5 1.3 -0.7 0.4 0.1 0.8 1.1 -0.1 0.8 0.6 1.0 0.9
Heart attack 0.5 0.7 1.9 -1.4 -0.1 -1.2 0.1 0.0 0.3 0.7 1.3 0.8 0.6
Allergy 0.2 0.4 1.4 -0.5 0.2 -1.2 0.8 -0.2 0.4 0.6 0.8 0.8 0.4
Pain all over the body in last month 0.6 0.6 2.1 0.3 -0.1 1.5 -1.1 -0.6 0.7 -0.8 -1.0 -0.6 -0.4
Diabetes (self-reported) 2.4 3.7 5.9 2.3 0.3 0.3 -2.4 -2.0 -1.2 -2.2 -2.3 -2.2 -2.3
Hayfever/allergic rhinitis (self-reported) 1.5 2.0 4.0 -1.4 -0.3 -1.1 1.7 1.3 0.2 1.9 2.0 1.4 1.7
Medication: Ramipril 1.4 1.8 3.6 -1.9 -1.7 -0.6 0.9 1.6 0.5 1.5 1.3 1.6 1.1
Medication: Simvastatin 0.2 0.3 0.7 -0.8 0.5 -0.9 0.2 -0.1 -0.5 0.5 0.4 0.6 -0.2
Fluid intelligence score 1.2 2.4 8.4 0.8 2.9 -0.9 -1.8 -1.5 -2.7 -0.9 0.7 -0.5 0.2
Illnesses of siblings 0.7 1.0 2.3 0.7 0.5 1.5 -1.1 -1.4 0.4 -0.8 -1.5 -0.6 -1.0
Neuroticism score 0.1 0.1 0.4 0.4 -0.1 -0.7 -0.3 -0.1 -0.5 -0.3 -0.2 -0.5 -0.0
Weight 0.3 1.4 4.0 1.0 -1.4 0.5 -1.7 -1.4 -0.3 -0.7 -2.0 -1.0 -0.9
Impedance of arm (right) 0.6 2.6 13.7 0.2 3.7 -1.3 -0.4 -1.6 -1.7 -0.4 2.2 0.2 0.8
Arm fat percentage (right) 0.3 1.2 3.9 1.0 -0.6 1.1 -1.3 -0.9 0.2 -0.9 -2.0 -1.1 -1.0
Trunk fat-free mass 0.3 1.5 3.4 1.2 -1.2 0.1 -1.9 -1.6 -0.9 -0.9 -1.6 -1.1 -1.0
Hip circumference 0.5 2.3 6.0 1.4 -1.9 1.1 -1.9 -1.6 -0.1 -1.1 -2.5 -1.4 -1.2
Time employed in main current job 0.5 0.6 1.1 -1.0 -0.9 -0.9 0.3 -0.5 -0.2 0.9 0.9 0.7 0.8
Alcohol intake versus 10 years previously 1.8 2.8 9.1 1.3 -1.1 3.0 -0.3 -1.3 0.6 -0.8 -2.5 -1.3 -2.2
Father’s age at death 0.1 0.1 0.4 0.6 0.2 0.1 0.4 0.5 -0.4 -0.4 0.1 0.1 -0.3
Worrier / anxious feelings 0.0 0.1 0.4 0.0 0.0 -0.6 -0.1 -0.2 0.1 0.0 -0.3 0.1 0.5
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.1 2.9 1.1 -0.4 0.4 -1.1 -0.3 -0.3 -1.5 -1.1 -1.7 -1.4
Falls in the last year 1.0 1.4 3.8 1.0 0.3 2.0 -1.2 -0.6 -0.4 -0.7 -1.9 -1.0 -1.2
Hair/balding pattern: Pattern 3 1.1 1.6 3.7 -1.7 -1.1 0.3 1.5 1.9 0.7 1.3 1.0 1.5 0.5
Number of live births 0.2 0.3 1.3 -0.0 -1.2 -0.4 0.3 0.8 0.6 -0.2 -0.0 -0.2 -0.5
Forced expiratory volume in 1-second (FEV1) 0.9 3.0 10.9 1.3 1.2 -1.4 -2.6 -3.3 -1.6 -1.8 -0.4 -1.1 -0.3
Pulse rate 0.1 0.1 0.4 -0.1 -0.4 -0.6 0.1 -0.1 0.5 0.1 0.1 0.6 0.3
Happiness 1.3 1.5 4.0 1.2 1.5 -2.0 -1.2 -0.6 -1.6 -1.0 0.9 -1.2 0.6
Noisy workplace 0.5 0.6 1.2 0.7 -1.0 0.4 -0.8 0.1 -0.2 -0.7 -0.9 -1.1 -1.1
Qualifications: A levels/AS levels or equivalent 0.7 1.6 4.3 -1.0 -0.7 -1.9 0.4 0.7 -0.8 0.9 1.8 1.1 2.1
Serious illness, injury or assault of a close relative in last 2 years 1.4 1.6 3.2 1.8 -0.4 1.4 -1.2 -0.7 0.1 -1.7 -1.7 -1.6 -1.0
Mouth/teeth dental problems: Dentures 0.3 0.5 1.0 0.1 -0.8 -1.0 0.9 -0.7 -1.0 0.3 0.4 -0.3 -1.0
Asthma 0.3 0.6 1.4 0.8 0.8 1.1 -0.6 0.2 -0.5 -0.5 -0.7 -1.2 -0.7
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 1.0 0.6 -0.0 0.8 -0.3 -0.6 0.7 -0.5 -1.0 -0.6 -0.6
Medication: Cholesterol lowering 0.7 1.0 3.3 -0.2 0.7 -1.8 -1.6 -1.4 -1.2 -0.5 0.4 -0.2 -0.4
Depression (self-reported) 1.4 1.7 2.9 1.5 0.6 -0.2 -1.4 -1.6 -0.5 -1.4 -1.5 -1.4 -1.7
Medication: Lansoprazole 1.3 1.5 3.6 0.7 1.4 0.3 -1.5 -1.2 -1.9 -0.7 -0.8 -1.4 -1.4
Prospective memory result 0.6 0.7 4.4 -0.2 -2.1 0.7 0.8 -0.4 0.3 0.1 -0.3 -0.2 -1.0
Lung cancer (father) 1.8 2.2 4.0 1.5 1.2 0.9 -1.7 -1.7 -0.8 -1.6 -1.5 -2.0 -1.4
Illnesses of mother 0.3 0.3 2.3 0.1 -1.5 0.7 -0.1 -0.1 0.6 0.1 -0.3 -0.2 0.4
Forced expiratory volume in 1-second (FEV1), Best measure 1.3 4.1 9.9 1.4 2.1 -1.9 -2.9 -3.1 -2.9 -1.9 0.0 -1.1 -0.3
Pulse wave Arterial Stiffness index 0.4 0.4 1.7 -0.6 0.3 -0.5 0.3 0.4 -0.5 0.7 1.3 0.4 0.9
Impedance of arm (left) 0.5 2.1 11.3 0.4 3.4 -1.1 -0.4 -1.8 -1.1 -0.6 1.8 0.1 0.6
Arm fat mass (right) 0.5 2.0 6.2 1.3 -1.0 1.1 -1.8 -1.3 -0.0 -1.2 -2.5 -1.4 -1.4
Trunk predicted mass 0.3 1.5 3.4 1.2 -1.2 0.1 -1.8 -1.6 -1.0 -0.9 -1.6 -1.1 -0.9
Standing height 0.4 4.2 14.3 1.6 1.9 -1.7 -2.7 -3.8 -3.0 -1.4 0.2 -0.8 -0.6
Length of working week for main job 6.0 6.6 10.1 2.8 1.5 1.8 -3.2 -2.9 -2.3 -2.9 -2.8 -2.7 -2.5
Exposure to tobacco smoke at home 0.5 0.5 2.5 -0.2 -1.6 1.0 0.4 0.1 0.9 0.7 -0.2 -0.0 0.4
Breastfed as a baby 0.6 0.8 3.4 -0.3 1.9 -0.9 0.1 -0.7 -0.5 0.0 1.4 0.4 0.7
Tense / ‘highly strung’ 0.5 0.8 2.2 -0.8 0.8 -1.5 -0.8 -0.6 -1.3 0.3 1.2 0.2 0.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.1 4.4 -0.6 0.8 -2.1 0.6 0.6 -0.5 0.3 1.9 0.3 0.9
Hair/balding pattern: Pattern 4 0.1 0.2 0.9 0.2 -0.4 0.1 0.2 0.5 0.1 0.4 -1.0 0.4 -0.1
Birth weight of first child 0.4 0.7 3.0 -0.2 1.7 -0.8 -0.2 -0.7 -1.3 0.2 0.8 0.2 0.3
Peak expiratory flow (PEF) 0.3 0.8 2.3 0.4 -0.1 -0.8 -1.5 -1.5 -1.5 -0.6 0.1 -0.3 0.2
Pulse wave reflection index 1.3 1.6 3.0 -1.1 0.2 -0.8 1.6 0.9 0.6 1.7 1.6 1.2 1.7
Ever highly irritable/argumentative for 2 days 0.2 0.3 1.0 0.2 0.4 -0.6 -0.8 0.0 -1.0 -0.4 0.3 -0.5 0.4
Loud music exposure frequency 0.5 0.5 2.5 0.4 0.5 -1.6 0.3 -0.1 -0.3 0.4 1.0 0.1 1.0
Qualifications: O levels/GCSEs or equivalent 1.6 2.6 5.0 -1.1 -1.4 -2.1 1.8 1.3 -0.7 1.2 2.2 1.9 1.8
Mouth/teeth dental problems: Bleeding gums 0.7 0.8 4.9 -0.6 -0.5 0.6 0.4 1.2 2.2 0.2 -0.4 0.5 0.7
Blood clot in the leg (DVT) 0.9 1.1 5.9 0.7 -0.3 2.4 0.2 0.5 -0.1 -0.4 -1.4 -0.8 -1.4
Medication: Paracetamol 0.9 1.5 3.2 -1.8 -1.7 0.1 0.8 0.1 -1.4 1.7 1.4 1.0 0.9
Headache pain in last month 0.5 0.9 3.4 -1.2 -0.7 -1.8 0.0 -0.5 0.5 0.9 1.2 0.5 0.9
Medication for cholesterol, blood pressure or diabetes 0.5 0.8 3.8 1.0 0.4 2.0 0.2 0.4 0.7 -0.6 -1.0 -0.7 -0.0
Glaucoma (self-reported) 2.4 2.8 7.4 1.5 1.4 0.1 -2.7 -2.3 -1.7 -1.7 -1.1 -1.7 -1.0
Gout (self-reported) 1.4 1.9 3.8 1.7 1.0 0.7 -1.5 -1.8 -1.5 -1.5 -0.6 -1.9 -1.1
Hypothyroidism/myxoedema (self-reported) 1.2 2.3 3.9 -2.0 -1.8 -0.3 1.5 1.6 1.2 1.6 1.4 1.9 1.0
Medication: Amlodipine 0.2 0.2 1.3 -0.3 -0.5 0.2 -1.1 -0.7 -0.4 0.0 -0.3 -0.2 -0.0
Medication: Ventolin 100micrograms inhaler 0.9 1.2 3.8 1.5 -0.3 1.9 -0.1 0.3 -0.3 -0.8 -1.2 -1.3 -1.3
Birth weight 0.8 1.7 3.9 -1.1 -0.6 -1.4 2.0 0.9 0.7 1.4 1.5 1.5 1.2
Chronic bronchitis/emphysema (mother) 0.5 0.6 2.2 -0.8 -0.3 -0.4 0.7 1.1 1.5 0.3 0.4 0.8 0.2
High blood pressure (siblings) 0.5 0.8 2.8 -0.2 1.1 -1.1 -0.3 0.1 -1.7 -0.1 1.3 0.2 0.6
Forced vital capacity (FVC), Best measure 2.2 8.0 19.6 2.0 2.6 -2.7 -4.0 -4.4 -3.8 -2.6 -0.0 -1.9 -1.0
Body fat percentage 0.3 1.1 3.8 0.8 -1.0 0.8 -1.3 -0.9 0.3 -0.7 -1.9 -0.8 -0.9
Leg fat percentage (right) 0.2 0.6 3.2 0.0 -1.8 0.2 -0.7 -0.2 0.3 0.1 -1.4 -0.2 -0.4
Arm fat-free mass (right) 0.3 1.4 3.7 0.9 -1.9 0.2 -1.5 -1.0 -0.3 -0.6 -1.9 -0.9 -1.0
Exposure to tobacco smoke outside home 0.6 0.7 2.4 0.7 -0.3 1.1 -0.1 -0.2 -0.3 -0.7 -1.5 -0.6 -1.5
Comparative body size at age 10 0.6 1.6 5.0 0.5 0.6 1.0 -2.2 -1.0 -1.5 -1.2 -1.2 -1.1 -1.3
Number of full brothers 0.3 0.4 1.6 0.2 0.5 -0.7 -0.5 -0.6 -1.3 -0.1 0.2 -0.5 -0.8
Worry too long after embarrassment 0.7 1.1 2.2 1.3 0.1 1.2 -0.7 -0.2 -0.7 -1.5 -1.4 -1.0 -1.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 1.0 0.7 -0.4 -1.0 0.0 -0.3 1.0 -0.8 -0.0 -0.7 -0.3
Wheeze or whistling in the chest in last year 0.1 0.2 0.5 -0.5 0.2 -0.2 -0.5 0.2 -0.6 0.3 0.5 -0.0 0.7
Number of children fathered 0.3 0.4 1.2 0.5 -0.8 -0.0 -1.1 -0.4 -0.0 -0.5 -1.1 -0.2 -0.4
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 1.5 -0.5 0.3 0.0 1.0 0.1 -0.1 1.1 0.8 0.9 1.2
Age at first live birth 0.3 0.5 1.2 -0.5 1.1 -0.3 0.2 -0.7 -0.4 0.6 1.1 0.7 1.0
Pulse wave peak to peak time 0.4 0.5 1.4 0.8 0.0 0.4 -0.5 -0.7 0.2 -0.8 -1.2 -0.6 -0.9
Health satisfaction 0.4 0.5 2.4 -0.0 -1.5 -0.4 0.2 0.8 1.2 -0.1 -0.3 0.0 0.3
Shortness of breath walking on level ground 0.6 0.7 1.6 -1.3 -0.8 -0.4 0.8 0.6 -0.3 1.0 1.0 1.0 0.5
Qualifications: College or University degree 1.3 4.0 9.1 1.5 2.5 -2.5 -2.5 -2.2 -3.0 -1.7 1.1 -1.2 0.6
Eye problems/disorders: None of the above 0.4 0.4 1.3 -0.5 0.4 -1.1 0.8 0.6 0.1 0.4 0.9 0.5 0.5
Mouth/teeth dental problems: Loose teeth 0.5 0.6 3.8 0.3 1.0 0.8 0.4 -0.2 1.9 -0.3 -0.5 -0.4 -0.4
Emphysema/chronic bronchitis 1.4 1.6 5.4 0.5 -1.9 2.3 0.4 1.4 1.2 -0.4 -1.3 -0.8 -1.0
Medication for pain relief, constipation, heartburn 0.3 0.6 4.2 0.9 2.0 -0.1 0.0 -0.1 -0.0 -0.5 0.2 -0.2 0.6
Neck or shoulder pain in last month 0.5 0.7 4.7 -0.1 -2.2 1.1 0.3 0.8 0.6 0.1 -0.3 -0.5 -0.3
Medication: Blood pressure 0.4 0.6 1.5 -1.2 -0.9 -1.0 -0.1 -0.1 -0.9 0.9 0.8 0.8 -0.2
Angina (self-reported) 0.6 0.8 1.8 -1.1 1.4 -0.0 0.3 0.4 0.9 0.8 1.2 0.8 1.1
Migraine (self-reported) 1.0 1.2 4.8 -1.3 -0.4 -2.2 -0.2 0.1 0.3 0.5 1.5 0.8 1.4
Medication: Ibuprofen 0.2 0.2 1.2 0.4 0.2 0.7 0.0 -0.2 1.1 -0.1 -0.6 -0.3 0.1
Medication: Allopurinol 1.7 2.2 4.8 2.0 0.5 1.2 -1.1 -1.4 -1.2 -1.5 -1.4 -2.2 -1.7
Medication: Omeprazole 0.4 0.5 1.7 -0.8 -1.3 -0.0 -0.0 0.8 1.0 0.3 -0.5 0.8 -0.5
Medication: Seretide 50 evohaler 1.1 1.3 3.3 1.4 0.6 -0.7 -1.8 -1.5 -0.3 -1.4 -0.7 -1.3 -0.4
Mean time to correctly identify matches 0.3 0.5 1.4 0.1 1.1 -0.9 -0.7 0.0 -1.2 -0.7 0.4 -0.5 -0.8
Heart disease (mother) 0.9 1.1 4.2 0.1 1.1 -1.8 -0.4 -0.4 -2.0 -0.4 1.3 -0.3 -0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 1.0 2.5 -0.9 -0.6 -1.0 -0.0 0.5 -0.9 0.6 1.6 1.0 1.6
Whole body fat mass 0.4 1.5 5.0 1.1 -1.4 0.8 -1.6 -1.1 0.1 -0.8 -2.2 -1.0 -1.0
Leg fat mass (right) 0.2 0.8 2.9 0.4 -1.7 0.1 -1.0 -0.6 0.0 -0.1 -1.6 -0.4 -0.5
Arm predicted mass (right) 0.3 1.4 4.2 0.9 -2.1 0.1 -1.5 -0.8 -0.3 -0.7 -2.0 -0.9 -1.1
Pulse rate, automated reading 0.2 0.5 1.2 0.8 -0.1 -1.0 -1.1 -0.8 0.4 -1.0 -0.4 -0.6 0.1
Alcohol intake frequency. 1.6 3.6 9.2 -0.4 -2.9 3.0 2.1 1.6 2.5 0.8 -1.7 0.3 -1.3
Comparative height size at age 10 0.6 3.4 7.5 2.2 2.2 -0.1 -2.2 -2.7 -2.0 -1.7 -0.9 -1.8 -1.4
Number of full sisters 0.4 0.5 1.0 0.9 0.4 -0.4 -0.5 -0.9 -1.0 -0.8 -0.0 -0.7 -0.6
Suffer from ‘nerves’ 1.0 1.6 4.3 -0.7 1.2 -1.9 1.0 -0.1 -0.5 1.1 2.1 0.5 1.8
Overall health rating 0.1 0.2 1.3 -0.6 -1.1 -0.4 -0.1 0.2 -0.3 0.3 0.1 0.2 -0.4
Chest pain or discomfort 0.2 0.3 1.1 -0.7 -0.3 0.1 0.3 0.5 1.0 0.4 0.3 0.3 0.5
Had major operations 0.6 0.7 1.6 0.6 1.2 0.2 -0.5 -1.3 -0.9 -0.8 -0.2 -0.9 -1.0
Age at last live birth 0.1 0.2 0.9 0.2 0.6 0.6 0.2 -0.9 -0.4 -0.0 0.3 -0.1 0.1
Family relationship satisfaction 0.8 1.0 3.0 0.4 1.2 -1.7 -0.7 -0.5 -1.4 -0.8 1.1 -0.4 0.5
Leg pain on walking 0.4 0.5 3.0 -0.2 -1.7 -0.5 0.7 0.8 0.2 0.7 -0.0 0.0 -0.2
Qualifications: NVQ or HND or HNC or equivalent 2.8 3.4 5.3 -1.9 -2.3 -0.0 2.2 2.0 1.9 2.1 0.9 2.2 1.4
Commuting to job workplace: Car/motor vehicle 0.2 0.2 0.8 -0.3 0.2 -0.0 0.0 0.4 0.4 0.8 0.4 0.3 0.9
Illness, injury, bereavement, stress in last 2 years 2.0 2.5 5.8 -2.2 0.2 -2.4 -0.0 0.4 -1.0 1.5 2.3 1.7 1.6
Medication: Aspirin 0.5 0.6 2.0 -1.3 -1.4 -0.6 0.0 0.9 0.2 0.6 0.1 0.7 -0.5
Supplements: Vitamin C 0.6 0.7 2.1 -0.7 -1.3 0.4 0.0 0.5 1.1 1.1 0.4 0.3 1.5
Knee pain experienced in last month 0.2 0.3 0.7 -0.5 -0.5 0.9 -0.7 0.1 -0.2 0.7 -0.8 0.1 0.1
Hypertension (Self-reported) 0.3 0.8 2.4 -1.5 0.3 -1.6 -0.1 0.1 -0.5 0.6 1.3 0.8 0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.9 2.2 5.1 -1.7 -1.1 0.1 1.6 2.3 2.1 1.6 1.0 1.4 0.9
Illnesses of father: Heart disease 1.1 1.6 4.7 -1.0 0.3 -1.6 0.5 1.3 -0.2 0.9 1.9 1.0 2.2
Illnesses of siblings: Diabetes 1.2 1.4 4.1 1.6 -0.5 0.8 0.3 0.1 0.7 -1.0 -1.7 -1.4 -2.0
Smoking status: Previous 1.3 1.9 3.8 -1.0 -1.2 -1.6 1.2 1.1 0.0 1.8 1.4 1.4 2.0
Forced expiratory volume in 1-second (FEV1), predicted 1.4 2.8 7.9 1.7 1.2 -1.0 -2.0 -2.8 -2.5 -1.5 -0.1 -1.4 -0.9
Whole body fat-free mass 0.3 1.7 3.7 1.3 -1.4 0.1 -1.9 -1.6 -0.8 -0.9 -1.9 -1.1 -1.0
Leg fat-free mass (right) 0.4 2.0 4.6 1.5 -1.1 0.2 -2.1 -1.7 -0.8 -1.2 -1.9 -1.4 -1.0
Arm fat percentage (left) 0.3 1.2 4.1 0.9 -0.9 1.0 -1.2 -0.9 0.4 -0.9 -2.0 -1.1 -0.9
Average weekly red wine intake 0.8 1.2 4.3 0.1 1.7 -0.6 -1.9 0.3 -2.1 -1.0 0.2 -0.5 0.1
Handedness (chirality/laterality): Left-handed 0.7 0.8 5.6 -0.3 0.0 -2.4 0.7 0.4 -0.2 0.7 1.1 0.5 0.4
Mood swings 0.1 0.2 0.8 0.2 0.9 -0.9 -0.4 0.2 -0.1 -0.1 0.2 -0.4 0.2
Loneliness, isolation 0.2 0.3 1.2 -0.5 -0.0 -1.1 0.8 0.2 -0.0 0.6 0.9 0.4 0.3
Long-standing illness, disability or infirmity 0.9 1.4 3.7 0.4 -1.6 1.6 0.4 0.9 1.9 -0.3 -1.3 -1.0 -1.2
Ever had bowel cancer screening 0.3 0.3 2.1 0.0 0.7 1.4 -0.0 -0.4 0.1 -0.2 -0.2 -0.4 -0.7
Diabetes diagnosed by doctor 1.8 3.0 4.9 2.0 0.1 0.7 -2.2 -1.8 -1.0 -1.9 -2.1 -2.0 -1.9
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 1.1 0.8 -0.1 0.4 -0.0 0.7 1.0 -0.5 -1.0 -0.6 -0.4
Friendships satisfaction 1.6 1.9 7.2 -0.6 1.5 -2.7 -0.2 0.0 -1.7 -0.0 2.2 0.7 1.2
Qualifications: nursing, teaching 0.8 1.2 4.7 -0.0 0.1 -2.2 -1.0 -0.9 -2.0 -0.4 0.9 0.1 0.5
Commuting to job workplace: Walk 0.5 0.6 1.7 -0.9 -1.3 -0.1 0.4 -0.1 -0.3 0.7 1.1 0.7 1.0
Eye problems/disorders: Cataract 0.8 0.9 2.9 -0.7 0.4 0.7 1.7 0.3 1.3 1.2 0.4 1.1 0.6
Mouth/teeth dental problems: Mouth ulcers 0.2 0.4 1.3 0.5 0.0 -0.2 -1.1 -0.2 -0.0 -1.1 -0.2 -0.8 -0.4
Medication for cholesterol 0.3 0.4 2.5 0.2 -0.2 0.6 1.0 0.3 1.6 0.4 -0.2 0.2 0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.2 2.5 5.9 1.8 1.8 0.6 -2.0 -0.9 -2.4 -1.2 -1.2 -1.7 -1.3
Back pain experienced in last month 1.3 1.8 8.0 1.0 0.1 2.8 -0.6 0.2 -0.2 -0.5 -2.2 -1.3 -1.5
Mineral and other dietary supplements 0.5 0.7 3.6 0.5 -1.2 0.2 1.1 0.4 1.9 -0.2 -0.4 -0.4 -0.4
Breast cancer (self-reported) 1.3 1.5 3.6 1.3 -0.4 0.5 -1.6 -0.1 -0.2 -1.9 -1.3 -1.6 -1.6
Asthma (self-reported) 0.3 0.5 1.3 0.8 0.9 1.0 -0.7 0.2 -0.4 -0.5 -0.7 -1.1 -0.5
Osteoporosis (self-reported) 0.3 0.3 1.7 -0.1 -0.5 0.3 1.3 0.7 -0.2 0.4 0.4 0.4 0.0
Osteoarthritis (self-reported) 2.7 3.5 5.5 2.0 -0.1 1.6 -2.2 -1.0 -2.1 -1.6 -2.3 -2.1 -2.3
Medication: Aspirin 0.3 0.4 1.2 -1.1 -0.8 -0.9 -0.2 0.7 -0.3 0.3 0.2 0.5 -0.7
Medication: Gliclazide 1.0 1.1 3.2 0.8 0.2 -0.3 -1.8 -0.5 -1.2 -0.9 -1.2 -1.1 -1.3
Illnesses of father: None of the above (group 1) 1.0 1.2 2.8 1.5 0.1 0.2 -0.4 -1.3 0.1 -1.0 -1.7 -1.3 -1.5
Smoking status: Current 0.5 0.9 2.9 1.2 0.5 0.8 0.2 -0.2 -0.6 -0.9 -0.7 -1.4 -1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.2 3.9 -0.3 1.1 -1.2 -1.3 -1.7 -2.0 -0.1 0.6 0.2 0.9
Whole body water mass 0.3 1.7 3.7 1.2 -1.4 0.1 -1.9 -1.4 -0.8 -1.0 -1.9 -1.2 -1.1
Leg predicted mass (right) 0.4 2.0 4.7 1.4 -1.1 0.1 -2.2 -1.8 -0.9 -1.2 -1.9 -1.4 -1.0
Arm fat mass (left) 0.3 1.2 4.6 0.8 -1.4 0.8 -1.4 -0.8 0.1 -0.6 -2.2 -0.9 -0.9
Number of self-reported non-cancer illnesses 0.1 0.2 0.8 -0.2 0.9 0.6 -0.0 -0.1 0.0 0.2 -0.3 -0.3 -0.7
Average weekly champagne plus white wine intake 0.7 0.9 3.1 0.8 -0.7 0.5 -0.7 0.4 0.7 -1.1 -1.7 -0.8 -1.2
Miserableness 0.3 0.5 1.5 -0.9 -1.2 -0.8 0.7 0.8 -0.1 0.5 0.7 0.6 0.7
Guilty feelings 0.3 0.4 1.5 -0.5 -1.0 -1.2 -0.3 0.6 0.4 0.2 0.4 0.3 0.7
Wears glasses or contact lenses 0.3 0.3 1.6 -0.0 -0.6 0.6 -0.3 0.4 1.3 -0.1 -0.8 -0.2 0.1
Ever taken oral contraceptive pill 0.8 0.9 2.7 0.8 1.0 0.4 -1.3 -1.7 -0.8 -0.9 -0.7 -0.9 -0.1
Hearing aid user 1.1 1.3 2.2 0.9 0.8 -0.8 -1.1 -1.5 -1.2 -1.3 -0.5 -1.3 -1.5
Mother’s age at death 0.2 0.2 0.9 0.1 0.4 -0.9 0.4 -0.3 -0.4 -0.1 0.6 0.5 -0.5
Financial situation satisfaction 0.9 1.1 3.0 0.3 -1.1 1.7 0.2 1.2 1.4 -0.2 -1.6 -0.6 -0.7
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.6 -0.1 -0.3 -0.8 0.0 -0.2 -0.2 0.4 0.2 -0.0 0.3
Commuting to job workplace: Public transport 0.1 0.1 0.3 -0.6 -0.5 -0.2 -0.2 0.1 0.0 -0.5 0.3 0.1 -0.0
Eye problems/disorders: Glaucoma 1.5 1.7 4.8 1.2 1.1 -0.6 -2.2 -1.8 -1.6 -1.2 -0.6 -1.4 -0.5
Medication: Blood pressure 0.5 0.9 2.7 -1.1 -0.1 -1.5 -0.1 0.4 -1.1 0.5 1.6 0.6 1.0
Pain type(s) experienced in last month: Hip pain 0.9 1.1 5.7 -0.1 -0.9 -1.7 -0.8 0.5 -2.4 0.1 0.1 -0.3 -0.8
Supplements: Fish oil (including cod liver oil) 0.8 1.1 3.5 0.3 1.7 -0.4 -1.9 -0.6 -1.7 -0.9 -0.1 -0.6 -0.1
High cholesterol (Self-reported) 0.8 1.4 2.6 -1.6 -0.5 -1.0 1.5 1.2 -0.2 1.6 1.2 1.5 0.4
Medication: Bendroflumethiazide 1.0 1.5 3.1 -1.6 0.5 -1.1 0.8 0.9 -0.8 1.8 1.7 1.1 1.4
Medication: Paracetamol 1.2 1.9 3.7 -1.9 -1.7 -0.6 1.1 0.4 -0.5 1.9 1.6 1.4 1.4
Medication: Lisinopril 2.6 3.4 8.0 1.7 0.3 2.8 -1.4 -1.4 -0.9 -1.4 -2.5 -1.6 -2.7
Medication: Atorvastatin 0.1 0.2 1.0 -0.1 0.1 -1.0 -0.2 -0.4 -0.2 0.0 0.6 -0.1 -0.1
Illnesses of father: High blood pressure 0.3 0.4 1.1 -0.5 0.9 0.7 0.1 -0.4 0.5 0.6 0.5 0.4 1.1
Alcohol drinker status: Never 1.4 1.7 6.6 -0.4 -2.6 1.9 1.4 1.0 1.2 0.5 -1.1 0.1 -0.6
Ever smoked 0.3 0.5 2.3 0.2 -0.1 -1.5 0.3 0.5 -1.1 0.4 0.8 -0.1 0.4
Basal metabolic rate 0.4 2.3 5.1 1.5 -1.3 0.4 -2.2 -1.8 -0.8 -1.2 -2.3 -1.4 -1.3
Leg fat percentage (left) 0.2 0.7 3.7 0.1 -1.9 0.3 -0.7 -0.3 0.6 0.0 -1.5 -0.3 -0.4
Arm fat-free mass (left) 0.3 1.5 4.4 1.1 -1.7 0.4 -1.7 -0.9 -0.5 -0.8 -2.1 -1.0 -1.1
Number of operations (self-reported) 2.7 4.0 10.0 2.3 1.3 1.1 -1.4 -1.3 -1.4 -2.4 -1.8 -2.7 -3.2
Average weekly beer plus cider intake 0.6 0.9 5.9 -0.4 -0.3 -2.4 -0.7 -0.2 -1.0 0.1 1.1 0.3 0.5
Irritability 0.3 0.5 2.0 0.2 0.8 -1.4 -0.2 -0.3 -1.4 0.0 0.1 -0.4 -0.7
Risk taking 1.2 1.8 3.6 1.3 1.4 0.5 -1.8 -1.1 -1.9 -1.1 -1.3 -1.5 -0.9
Ever had prostate specific antigen (PSA) test 0.2 0.2 0.5 0.7 -0.6 -0.6 -0.2 -0.1 0.2 -0.5 -0.3 -0.4 -0.6
Fractured/broken bones in last 5 years 1.9 2.4 5.0 -1.5 -2.2 -1.3 2.2 0.6 -0.4 1.9 1.5 1.8 1.0
Age started oral contraceptive pill 1.2 1.5 2.9 -1.4 -0.8 1.2 1.5 1.7 1.7 1.1 0.3 1.4 0.5
Diastolic blood pressure, automated reading 0.0 0.1 0.4 -0.2 0.2 0.3 -0.2 0.6 0.7 -0.1 -0.1 -0.2 0.3
Ever depressed for a whole week 0.5 0.6 2.0 -0.6 -0.1 -1.0 0.2 0.3 0.2 0.4 1.4 0.2 1.4
Unable to work because of sickness or disability 2.2 2.9 5.4 1.7 0.9 -0.3 -2.3 -2.0 -1.0 -1.9 -1.4 -2.2 -1.9
Commuting to job workplace: Cycle 1.0 1.2 3.3 -1.0 0.8 -1.8 -0.5 -0.0 -1.5 0.6 1.5 0.8 1.2
Myopia 0.8 1.1 2.9 1.4 -0.4 1.7 0.7 1.1 1.2 -0.3 -1.6 -0.7 -0.4
Vascular/heart problems diagnosed by doctor 0.2 0.7 2.4 1.6 -0.1 1.1 0.0 -0.4 -0.1 -0.5 -1.3 -0.6 -0.5
Cholesterol lowering medication 0.2 0.4 1.4 -0.4 0.0 0.5 0.9 1.2 0.0 0.3 -0.1 0.3 -0.8
Medication: Omeprazole (e.g. Zanprol) 0.2 0.3 0.7 -0.3 -0.8 0.3 -0.5 0.4 0.6 -0.2 -0.7 0.1 -0.8
Pain experienced in last month 0.5 0.8 3.7 1.2 1.9 -0.6 0.3 -0.9 -0.3 -0.9 0.1 -0.5 -0.4
Supplements: Calcium 0.7 0.8 1.8 -0.6 -1.0 0.3 1.2 1.4 0.6 1.3 0.3 0.9 0.6
Basal cell carcinoma (self-reported) 0.3 0.4 1.0 -0.7 -0.4 -0.6 -0.3 -1.0 -1.0 0.1 0.7 0.3 -0.5
Heart attack/myocardial infarction (self-reported) 0.6 0.8 2.3 -1.4 0.1 -1.5 -0.0 -0.1 0.2 0.6 1.4 0.8 0.6
Deep venous thrombosis (DVT) (self-reported) 0.8 1.1 5.4 0.5 -0.8 2.3 0.5 0.8 0.0 -0.2 -1.2 -0.6 -1.2
Heart disease (siblings) 2.3 2.8 5.2 -1.8 -2.3 -1.9 1.4 1.4 0.5 1.7 2.0 1.3 1.7
Alcohol drinker status: Previous 0.2 0.2 1.5 0.3 -0.5 0.1 0.4 0.3 1.2 0.1 -0.5 -0.1 -0.3
Pack years of smoking 0.2 0.3 1.5 0.3 -0.7 0.3 0.2 0.1 -0.8 -0.0 -0.6 -0.5 -1.2
Impedance of whole body 0.3 1.5 7.3 -0.1 2.7 -1.2 0.1 -1.2 -0.5 -0.1 1.8 0.5 0.8
Leg fat mass (left) 0.2 0.9 3.2 0.5 -1.8 0.2 -1.1 -0.7 0.2 -0.2 -1.8 -0.5 -0.6
Arm predicted mass (left) 0.2 1.1 3.3 0.6 -1.8 0.1 -1.6 -0.7 -0.4 -0.4 -1.8 -0.6 -0.8