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chr7:99,081,730-101,577,038

Best TWAS P=2.94e-53 · Best GWAS P=1.22e-40 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	GIGYF1	0.08	0.01	blup	295	0.06	9.2e-08	-7.106	-6.8	9.3e-12	0.12	0.52	0.02	FALSE
2	GTEx	Adipose Subcutaneous	SRRT	0.14	0.04	enet	40	0.06	2.0e-05	10.769	-6.6	3.1e-11	-0.45	0.01	0.94	FALSE
3	GTEx	Adipose Subcutaneous	GIGYF1	0.14	0.10	enet	22	0.14	1.9e-11	-7.154	-7.8	6.4e-15	0.06	1.00	0.00	FALSE
4	GTEx	Adipose Visceral Omentum	GIGYF1	0.12	0.07	lasso	3	0.04	5.0e-03	-7.257	-7.2	7.3e-13	-0.01	0.12	0.04	FALSE
5	GTEx	Adrenal Gland	GIGYF1	0.23	0.14	lasso	1	0.07	1.2e-03	-7.154	-7.2	8.5e-13	-0.06	0.17	0.11	FALSE
6	GTEx	Artery Aorta	ACHE	0.35	0.31	enet	35	0.32	1.9e-18	-10.709	-7.6	3.8e-14	-0.06	1.00	0.00	FALSE
7	GTEx	Artery Aorta	SRRT	0.11	0.09	enet	20	0.09	1.4e-05	-10.710	-9.5	1.9e-21	-0.23	0.42	0.08	FALSE
8	GTEx	Artery Aorta	GIGYF1	0.14	0.11	enet	9	0.11	1.1e-06	-7.154	-7.2	7.6e-13	0.06	0.79	0.01	FALSE
9	GTEx	Artery Aorta	UFSP1	0.15	0.00	enet	49	0.02	3.3e-02	3.480	-6.3	3.6e-10	-0.64	0.04	0.86	FALSE
10	GTEx	Artery Tibial	ACHE	0.10	0.09	lasso	5	0.08	9.2e-07	-10.710	-10.7	9.2e-27	-0.31	0.92	0.01	FALSE
11	GTEx	Artery Tibial	SRRT	0.14	0.02	enet	12	0.02	8.8e-03	12.905	-15.1	9.7e-52	-0.88	0.01	0.96	FALSE
12	GTEx	Artery Tibial	GIGYF1	0.13	0.04	enet	23	0.05	1.5e-04	-7.984	-5.9	4.6e-09	0.04	0.39	0.03	FALSE
13	GTEx	Brain Caudate basal ganglia	TFR2	0.14	0.00	enet	16	0.00	2.3e-01	1.685	6.1	1.1e-09	0.13	0.06	0.21	FALSE
14	GTEx	Brain Cerebellar Hemisphere	ZCWPW1	0.17	0.01	lasso	5	0.01	1.9e-01	-2.117	5.3	8.8e-08	0.57	0.03	0.42	FALSE
15	GTEx	Brain Putamen basal ganglia	STAG3	0.36	0.03	lasso	12	0.09	3.1e-03	-7.106	-6.1	1.1e-09	-0.01	0.11	0.28	FALSE
16	GTEx	Brain Putamen basal ganglia	GIGYF1	0.31	-0.01	lasso	5	-0.01	5.1e-01	-7.984	-6.1	1.1e-09	0.09	0.07	0.08	FALSE
17	GTEx	Breast Mammary Tissue	GIGYF1	0.23	0.07	enet	14	0.09	2.4e-05	-7.257	-5.9	2.9e-09	0.11	0.29	0.03	FALSE
18	GTEx	Cells Transformed fibroblasts	GIGYF1	0.21	0.16	lasso	9	0.19	6.2e-14	-7.154	-7.0	2.5e-12	-0.03	1.00	0.00	TRUE
19	GTEx	Cells Transformed fibroblasts	EPHB4	0.25	0.16	lasso	4	0.16	1.1e-11	10.764	12.0	2.0e-33	0.59	0.98	0.02	FALSE
20	GTEx	Colon Sigmoid	CLDN15	0.29	0.00	lasso	4	0.00	4.5e-01	-4.220	-6.5	1.1e-10	-0.08	0.36	0.11	FALSE
21	GTEx	Colon Transverse	GIGYF1	0.20	0.05	enet	19	0.09	4.9e-05	-7.257	-6.0	2.7e-09	0.23	0.54	0.02	TRUE
22	GTEx	Esophagus Gastroesophageal Junction	GIGYF1	0.29	0.09	lasso	3	0.12	5.6e-05	-8.074	-8.0	9.6e-16	-0.06	0.69	0.02	FALSE
23	GTEx	Esophagus Mucosa	TRIP6	0.15	0.16	lasso	2	0.15	4.7e-10	13.149	13.1	1.7e-39	0.99	0.02	0.98	FALSE
24	GTEx	Esophagus Mucosa	MOSPD3	0.16	0.08	enet	15	0.09	1.1e-06	-2.625	5.6	1.9e-08	0.34	0.92	0.01	FALSE
25	GTEx	Esophagus Mucosa	GIGYF1	0.10	0.01	enet	15	0.07	1.0e-05	-7.154	-7.4	1.7e-13	0.11	0.57	0.02	FALSE
26	GTEx	Esophagus Muscularis	GIGYF1	0.22	0.12	enet	13	0.15	3.3e-09	-7.154	-5.7	1.3e-08	0.03	0.99	0.00	FALSE
27	GTEx	Heart Atrial Appendage	ACHE	0.19	0.19	lasso	2	0.18	2.6e-08	-10.710	-10.6	3.7e-26	-0.29	0.95	0.00	FALSE
28	GTEx	Heart Atrial Appendage	SRRT	0.14	0.01	enet	10	0.02	4.5e-02	-10.710	-8.4	3.1e-17	-0.17	0.10	0.06	FALSE
29	GTEx	Heart Atrial Appendage	GIGYF1	0.12	0.07	lasso	8	0.05	2.8e-03	-10.710	-9.4	4.2e-21	-0.06	0.16	0.04	FALSE
30	GTEx	Heart Left Ventricle	GIGYF1	0.09	0.02	lasso	4	0.02	2.0e-02	-8.074	-6.2	5.4e-10	0.09	0.14	0.06	FALSE
31	GTEx	Lung	GIGYF1	0.25	0.13	lasso	7	0.14	4.0e-11	-7.257	-7.8	6.0e-15	-0.06	1.00	0.00	FALSE
32	GTEx	Lung	UFSP1	0.09	0.05	lasso	3	0.05	1.9e-04	13.348	-13.2	5.2e-40	-0.99	0.00	0.98	FALSE
33	GTEx	Muscle Skeletal	GIGYF1	0.10	0.03	enet	14	0.06	6.8e-07	-7.106	-8.8	1.4e-18	-0.04	0.96	0.00	FALSE
34	GTEx	Nerve Tibial	TRIP6	0.10	0.08	enet	23	0.11	3.9e-08	0.049	-5.8	8.7e-09	0.27	0.94	0.00	FALSE
35	GTEx	Nerve Tibial	ACHE	0.28	0.23	lasso	7	0.22	6.1e-16	-10.710	-10.7	1.5e-26	-0.31	1.00	0.00	FALSE
36	GTEx	Nerve Tibial	SRRT	0.13	0.12	lasso	4	0.11	3.7e-08	-10.982	-11.1	7.4e-29	-0.32	0.99	0.01	FALSE
37	GTEx	Nerve Tibial	GIGYF1	0.17	0.14	enet	7	0.14	2.3e-10	-7.106	-7.2	4.4e-13	-0.04	1.00	0.00	FALSE
38	GTEx	Ovary	GIGYF1	0.23	0.15	lasso	5	0.14	2.9e-04	-11.542	-11.4	7.4e-30	-0.25	0.20	0.04	FALSE
39	GTEx	Prostate	GIGYF1	0.51	0.06	lasso	10	0.05	2.0e-02	-7.078	-7.1	1.3e-12	0.06	0.07	0.07	FALSE
40	GTEx	Skin Not Sun Exposed Suprapubic	GIGYF1	0.11	0.00	lasso	5	0.00	2.2e-01	-9.050	-9.1	6.5e-20	-0.17	0.09	0.04	FALSE
41	GTEx	Skin Sun Exposed Lower leg	ACHE	0.07	0.10	lasso	1	0.09	3.5e-08	-10.710	-10.7	9.2e-27	-0.31	0.99	0.00	FALSE
42	GTEx	Skin Sun Exposed Lower leg	SRRT	0.13	0.09	enet	6	0.08	1.9e-07	13.152	-13.2	5.1e-40	-0.99	0.01	0.99	FALSE
43	GTEx	Skin Sun Exposed Lower leg	GIGYF1	0.11	0.07	enet	12	0.09	1.4e-07	-7.984	-6.8	1.2e-11	0.01	0.97	0.00	FALSE
44	GTEx	Spleen	GIGYF1	0.22	0.00	enet	19	0.10	1.3e-03	-8.074	-6.4	1.8e-10	0.14	0.11	0.23	FALSE
45	GTEx	Stomach	GIGYF1	0.24	0.03	lasso	5	0.07	4.7e-04	-7.078	-6.5	9.8e-11	-0.02	0.35	0.03	FALSE
46	GTEx	Testis	GIGYF1	0.23	0.05	enet	17	0.17	7.4e-08	-7.984	-5.6	2.2e-08	0.09	0.89	0.01	FALSE
47	GTEx	Thyroid	ACHE	0.19	0.10	enet	33	0.14	1.5e-10	-10.710	-5.6	2.4e-08	-0.02	1.00	0.00	FALSE
48	GTEx	Thyroid	GIGYF1	0.33	0.24	lasso	7	0.24	1.5e-18	-7.257	-7.6	3.1e-14	-0.05	1.00	0.00	FALSE
49	GTEx	Vagina	RP11-758P17.3	0.44	-0.01	enet	37	0.04	4.7e-02	-0.789	5.9	3.1e-09	0.36	0.03	0.13	FALSE
50	GTEx	Whole Blood	GIGYF1	0.04	0.02	lasso	5	0.01	5.5e-02	-7.106	-6.9	6.2e-12	0.01	0.16	0.03	FALSE
51	METSIM	Adipose	UFSP1	0.06	0.03	lasso	5	0.04	4.0e-07	12.612	-9.3	1.8e-20	-0.87	0.16	0.83	FALSE
52	ROSMAP	Brain Pre-frontal Cortex	SRRT	0.05	0.02	bslmm	331	0.02	1.1e-03	-10.710	-8.1	8.4e-16	-0.16	0.51	0.02	FALSE
53	YFS	Blood	GNB2	0.04	0.00	bslmm	286	0.01	6.5e-05	-0.886	-9.6	7.0e-22	-0.43	0.03	0.44	FALSE
54	YFS	Blood	SLC12A9	0.04	0.02	enet	11	0.02	9.0e-07	10.775	-12.1	1.7e-33	-0.53	0.85	0.14	FALSE
55	YFS	Blood	TRIP6	0.08	0.10	lasso	6	0.11	6.7e-35	-10.710	9.8	1.0e-22	0.21	1.00	0.00	FALSE
56	YFS	Blood	UFSP1	0.20	0.29	lasso	12	0.33	1.2e-113	-1.515	-6.9	4.2e-12	-0.84	1.00	0.00	FALSE
57	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TRIP6	0.12	0.03	enet	16	0.08	3.9e-07	13.348	15.4	2.9e-53	0.83	0.01	0.99	TRUE
58	The Cancer Genome Atlas	Breast Invasive Carcinoma	ACHE	0.03	0.01	blup	56	0.01	1.8e-03	-11.229	-8.1	4.3e-16	-0.44	0.03	0.06	FALSE
59	The Cancer Genome Atlas	Breast Invasive Carcinoma	TRIP6	0.03	0.03	lasso	4	0.02	6.8e-06	12.612	12.9	5.6e-38	0.97	0.02	0.98	FALSE
60	The Cancer Genome Atlas	Breast Invasive Carcinoma	UFSP1	0.06	0.02	blup	52	0.04	1.5e-08	12.931	-9.8	8.8e-23	-0.88	0.03	0.97	FALSE
61	The Cancer Genome Atlas	Glioblastoma Multiforme	EPHB4	0.16	0.11	enet	7	0.07	3.8e-03	-10.710	9.9	2.9e-23	0.32	0.05	0.05	FALSE
62	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	GNB2	0.03	0.01	blup	31	0.02	1.3e-03	-7.984	5.9	3.2e-09	-0.05	0.00	0.79	TRUE
63	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TRIM56	0.06	0.01	blup	38	0.02	4.2e-03	-3.422	-6.0	1.4e-09	-0.14	0.01	0.67	FALSE
64	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	UFSP1	0.07	0.06	blup	53	0.09	4.3e-10	3.143	-6.9	5.7e-12	-0.85	0.12	0.88	FALSE
65	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	UFSP1	0.10	0.03	blup	53	0.08	1.7e-05	12.612	-10.6	2.5e-26	-0.91	0.01	0.99	FALSE
66	The Cancer Genome Atlas	Brain Lower Grade Glioma	EPO	0.03	0.00	blup	33	0.00	1.4e-01	-7.106	7.4	1.9e-13	0.24	0.01	0.17	FALSE
67	The Cancer Genome Atlas	Brain Lower Grade Glioma	GIGYF1	0.05	0.06	lasso	3	0.06	4.7e-07	-7.106	-7.1	1.2e-12	-0.06	0.56	0.43	FALSE
68	The Cancer Genome Atlas	Brain Lower Grade Glioma	UFSP1	0.09	0.05	blup	52	0.09	5.6e-10	12.931	-9.0	2.0e-19	-0.89	0.07	0.93	TRUE
69	The Cancer Genome Atlas	Lung Adenocarcinoma	GIGYF1	0.03	0.02	blup	30	0.02	4.7e-03	-7.078	-6.8	9.8e-12	0.04	0.02	0.41	FALSE
70	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	UFSP1	0.03	0.01	blup	53	0.02	1.6e-03	12.926	-10.3	5.7e-25	-0.92	0.01	0.70	FALSE
71	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	EPHB4	0.20	0.07	blup	50	0.10	6.9e-05	-11.387	13.4	4.4e-41	0.47	0.07	0.11	FALSE
72	The Cancer Genome Atlas	Prostate Adenocarcinoma	GIGYF1	0.04	0.03	blup	29	0.03	1.7e-04	-8.074	-7.2	4.8e-13	0.02	0.00	0.97	FALSE
73	The Cancer Genome Atlas	Prostate Adenocarcinoma	UFSP1	0.05	0.04	blup	53	0.06	4.8e-07	-1.300	-6.8	1.1e-11	-0.84	0.04	0.95	FALSE
74	The Cancer Genome Atlas	Soft Tissue Sarcoma	TRIM56	0.10	0.07	lasso	2	0.05	7.3e-04	7.002	-7.0	2.5e-12	-0.15	0.00	1.00	TRUE
75	The Cancer Genome Atlas	Soft Tissue Sarcoma	UFSP1	0.06	0.02	blup	53	0.05	3.5e-04	0.206	-5.8	9.0e-09	-0.81	0.05	0.69	FALSE
76	The Cancer Genome Atlas	Testicular Germ Cell Tumors	EPHB4	0.30	0.20	lasso	5	0.18	8.1e-07	-11.387	-13.0	1.1e-38	-0.47	0.21	0.66	FALSE
77	The Cancer Genome Atlas	Thyroid Carcinoma	ACHE	0.04	0.04	lasso	2	0.03	3.0e-04	-10.982	-11.0	4.7e-28	-0.32	0.32	0.05	FALSE
78	The Cancer Genome Atlas	Thyroid Carcinoma	EPHB4	0.05	0.04	lasso	1	0.02	2.8e-03	-11.387	11.4	4.8e-30	0.26	0.15	0.03	FALSE
79	The Cancer Genome Atlas	Thyroid Carcinoma	GIGYF1	0.04	0.03	blup	30	0.03	8.4e-04	-7.078	-7.0	3.2e-12	0.10	0.01	0.74	TRUE
80	The Cancer Genome Atlas	Thyroid Carcinoma	UFSP1	0.08	0.11	lasso	3	0.12	1.2e-11	12.926	-10.6	4.0e-26	-0.95	0.01	0.99	FALSE