TWAS hub - MOSPD3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.1630	0.0530	1.8e-05	0.080	NA	0.091	NA	0.091	5.2e-06	NA	1.1e-06	NA	1.1e-06
2	GTEx	Nerve Tibial	0.0748	0.0321	1.4e-03	0.027	NA	0.024	NA	0.031	5.1e-03	NA	8.1e-03	NA	2.8e-03
3	GTEx	Skin Not Sun Exposed Suprapubic	0.1480	0.0640	6.6e-04	0.128	NA	0.086	NA	0.104	1.7e-07	NA	1.9e-05	NA	2.6e-06
4	GTEx	Skin Sun Exposed Lower leg	0.2930	0.0680	1.6e-10	0.197	NA	0.167	NA	0.186	3.6e-16	NA	9.2e-14	NA	2.6e-15
5	GTEx	Whole Blood	0.2380	0.0540	1.6e-11	0.204	NA	0.158	NA	0.182	1.6e-18	NA	1.9e-14	NA	1.4e-16
6	TCGA	Brain Lower Grade Glioma	0.0243	0.0151	7.8e-03	0.022	0.015	0.005	NA	0.015	1.2e-03	0.0074	7.4e-02	NA	6.8e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Blood Red Count	118.5	1144.3	1436.4	-37.2	-32.0	-37.0	-37.9	-25.2	31.9
Blood Platelet Count	17.6	204.0	262.4	15.4	15.2	16.2	14.0	11.1	-13.2
Pulse rate, automated reading	8.3	26.8	63.4	-5.5	4.0	-3.3	-0.2	8.0	-6.4
Lung cancer (father)	7.0	8.2	11.2	2.1	3.1	2.5	2.7	3.3	-3.2
Supplements: Fish oil (including cod liver oil)	6.9	9.0	13.0	3.5	3.1	3.6	3.2	2.3	-2.0
Pulse rate	5.0	8.4	17.6	-4.0	1.7	-2.2	-0.8	4.2	-2.9
Reason for reducing amount of alcohol drunk: Health precaution	4.4	5.2	7.3	-2.0	-2.7	-2.4	-2.1	-2.1	2.2
Schizophrenia vs Biploar Disorder	4.2	5.6	9.7	-3.1	-2.2	-3.0	-2.8	-1.5	0.0
Age at First Birth	4.0	5.8	9.6	3.0	2.4	2.9	3.1	1.5	0.0
Reaction Time	3.8	7.1	16.6	-4.1	-0.2	-3.9	-3.2	-0.6	0.7
Ulcerative Colitis (UC)	3.0	5.6	13.9	-0.6	2.6	-0.2	1.2	3.7	-3.3
Stomach or abdominal pain in last month	3.0	3.7	9.7	-0.5	-1.9	-0.4	-1.3	-2.6	3.1
Risk taking	3.0	4.4	8.9	-2.6	-1.5	-3.0	-2.3	-0.7	1.6
Breast Cancer	2.9	7.1	9.7	-3.1	-2.7	-3.1	-2.5	-1.9	2.6
Medication: Metformin	2.9	4.1	6.1	1.8	1.2	2.1	2.2	2.5	-2.2
Pulse wave reflection index	2.9	3.6	4.8	-1.5	-1.5	-2.2	-2.1	-2.0	1.9
Pulse wave peak to peak time	2.9	3.5	6.1	2.5	1.7	2.0	2.1	0.9	-1.6
Cholesterol lowering medication	2.6	3.8	9.2	-1.4	1.9	-0.5	0.9	3.0	-2.6
Pulse wave Arterial Stiffness index	2.5	2.9	5.1	-2.2	-1.7	-1.8	-1.9	-0.9	1.6
Average weekly champagne plus white wine intake	2.5	3.5	7.1	-0.7	-2.6	-0.7	-1.2	-2.7	2.1
Crohns Disease (2012)	2.4	3.9	8.0	-2.8	-1.4	-2.8	-2.2	-0.5	0.8
Mean Putamen Volume	2.4	2.7	5.9	-1.9	-2.4	-1.8	-1.3	-1.0	1.0
Medication: Atenolol	2.4	3.0	5.1	1.9	0.6	2.2	2.2	1.3	-1.5
Glaucoma (self-reported)	2.4	2.8	4.7	-1.6	-0.8	-2.1	-2.2	-1.8	1.3
Financial situation satisfaction	2.4	3.0	4.4	1.4	2.1	1.3	1.5	2.0	-1.9
Eye problems/disorders: Glaucoma	2.4	2.8	5.5	-1.5	-0.4	-2.1	-2.4	-1.8	1.2
Supplements: Zinc	2.3	2.5	4.6	-1.1	-2.1	-1.3	-1.4	-1.3	2.0
Schizophrenia (2014)	2.2	4.9	12.5	-3.5	-0.4	-3.4	-2.2	0.6	0.0
Serious illness, injury or assault to yourself	2.2	2.7	4.9	-1.9	0.1	-2.0	-2.2	-0.6	1.7
Blood clot in the leg (DVT)	2.2	2.8	6.7	2.6	1.6	2.1	1.6	0.5	-0.8
Mean time to correctly identify matches	2.2	4.1	9.7	-3.1	0.5	-3.0	-2.3	-0.2	0.2
Rheumatoid Arthritis	2.1	2.9	4.7	1.7	2.2	1.6	1.5	1.7	-1.5
Hayfever, allergic rhinitis or eczema	2.1	4.5	8.3	-2.1	-1.3	-1.5	-2.2	-2.4	2.9
Forced expiratory volume in 1-second (FEV1), predicted	2.1	4.4	7.5	2.4	1.6	2.7	2.5	1.4	-1.6
Falls in the last year	2.0	2.7	6.3	0.5	1.6	1.0	1.4	2.5	-2.1
Happiness	2.0	2.5	3.5	-1.8	-0.6	-1.9	-1.8	-1.4	1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.0	2.3	4.7	2.1	0.8	2.2	1.7	0.6	-1.0
Allergy	1.9	4.3	8.5	1.8	1.4	1.3	2.1	2.5	-2.9
Guilty feelings	1.9	2.9	5.9	-2.4	-0.8	-2.2	-1.9	-0.7	1.2
Depression (Nagel 2018)	1.8	2.7	7.0	-2.1	0.1	-2.6	-2.1	-0.4	0.5
Irritable Bowel Disease (IBD)	1.8	4.3	9.4	-2.0	1.4	-1.7	-0.2	3.1	-2.7
Heel T-Score	1.8	14.1	25.1	-5.0	-3.4	-4.9	-3.3	-2.3	2.9
Alcohol usually taken with meals	1.8	3.0	5.6	-0.8	-2.4	-0.9	-1.3	-2.1	2.1
Frequency of tenseness / restlessness in last 2 weeks	1.8	2.8	5.3	-2.3	-1.0	-2.3	-1.9	-0.9	0.7
Medication: Cholesterol lowering	1.8	2.7	4.8	1.4	1.2	1.3	1.6	2.0	-2.2
Mineral and other dietary supplements	1.8	2.4	4.9	-2.1	-1.4	-2.2	-1.6	-0.5	0.2
Breast cancer (self-reported)	1.8	2.1	3.5	1.9	1.3	1.5	1.1	1.5	-1.2
Deep venous thrombosis (DVT) (self-reported)	1.8	2.3	5.9	2.4	1.4	1.9	1.4	0.5	-0.6
Family relationship satisfaction	1.7	2.1	4.9	-2.2	-0.4	-2.1	-1.6	0.1	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.7	2.0	5.8	-0.1	0.9	0.6	1.2	2.4	-1.9
Medication: Atorvastatin	1.7	2.1	5.9	0.0	1.1	0.4	1.2	2.4	-1.9
Diastolic blood pressure, automated reading	1.7	5.3	13.5	-3.7	-0.7	-3.2	-2.8	0.0	0.3
Other serious medical condition/disability diagnosed by doctor	1.6	2.1	5.1	0.2	2.2	0.9	1.3	1.5	-1.6
Systolic blood pressure, automated reading	1.6	4.6	8.3	2.8	2.2	2.9	2.1	0.3	-1.4
Medication: Simvastatin	1.6	2.4	4.9	0.5	1.5	1.0	1.4	1.9	-2.2
Wheeze or whistling in the chest in last year	1.6	2.9	6.4	-2.5	-1.3	-2.2	-1.9	0.0	1.0
Chest pain or discomfort	1.6	2.3	3.5	-1.7	-1.3	-1.8	-1.9	-1.3	1.1
Worrier / anxious feelings	1.5	2.8	6.6	-2.6	-0.2	-2.3	-2.0	-0.5	0.7
Friendships satisfaction	1.5	1.8	5.4	-2.3	0.2	-1.8	-1.3	0.1	0.6
Schizophrenia (2018)	1.4	3.0	7.9	-2.8	-0.3	-2.6	-1.5	1.0	-0.4
Handedness (chirality/laterality): Left-handed	1.4	1.7	3.5	0.5	1.0	0.3	1.3	1.9	-1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	3.0	5.1	2.2	1.2	1.8	1.7	1.4	-1.9
Mouth/teeth dental problems: Mouth ulcers	1.3	2.0	2.9	-1.7	-1.5	-1.7	-1.4	-1.2	1.1
Ulcerative Colitis	1.2	1.8	3.8	-1.9	1.1	-1.2	-0.6	1.3	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	3.1	-1.8	1.1	-1.7	-0.9	0.8	-0.9
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	4.1	1.9	0.7	2.0	1.1	-0.4	0.6
Mouth/teeth dental problems: Dentures	1.2	2.0	4.1	1.4	1.2	2.0	1.5	0.8	-1.2
Bipolar Disorder or Schizophrenia	1.1	2.8	7.7	-2.8	-0.1	-2.3	-1.2	1.4	-0.6
Crohns Disease (2017)	1.1	2.3	5.0	-2.2	-0.2	-2.2	-1.2	1.3	-1.0
HbA1C	1.1	1.2	2.5	-1.2	-1.0	-1.3	-1.6	-0.8	0.0
Allergy or Eczema	1.1	2.9	5.0	-1.7	-1.2	-1.2	-1.7	-1.9	2.2
Hypothyroidism (self reported)	1.1	2.5	5.9	2.4	0.1	2.3	1.4	-1.4	0.4
Lung FEV1/FVC ratio	1.1	5.5	8.9	3.0	2.9	2.4	2.0	1.6	-1.9
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	2.2	-0.9	-0.4	-0.7	-1.3	-1.3	1.5
Had menopause	1.1	1.3	4.4	0.6	2.1	0.9	0.8	0.9	-0.9
Breastfed as a baby	1.1	1.4	4.0	0.2	-1.3	0.1	-0.6	-2.0	1.4
Medication: Paracetamol	1.1	1.9	2.8	-1.4	-1.6	-0.9	-1.3	-1.2	1.7
Medication for cholesterol, blood pressure or diabetes	1.1	1.9	3.6	-1.0	-0.5	-1.1	-1.4	-1.8	1.9
Hypothyroidism/myxoedema (self-reported)	1.1	2.2	5.8	2.4	0.2	1.9	1.1	-1.5	0.4
Chronic bronchitis/emphysema (mother)	1.1	1.3	3.3	-1.8	-0.3	-1.6	-1.3	0.4	0.2
Worry too long after embarrassment	1.1	1.9	4.1	-1.7	-0.4	-2.0	-1.8	-0.6	0.6
Prostate Cancer	1.0	1.5	3.2	-1.1	0.3	-1.6	-1.8	-1.0	1.0
Body Mass Index (BMI) (2010)	1.0	1.4	3.3	-1.6	-0.6	-1.8	-1.4	-0.2	0.0
Systolic Blood Pressure	1.0	5.2	14.2	3.8	1.0	3.3	2.1	-0.8	-0.6
Age when periods started (menarche)	1.0	2.3	4.2	0.9	1.4	1.2	1.8	2.0	-1.6
Qualifications: None of the above	1.0	2.2	4.3	1.6	2.1	1.2	1.0	1.2	-1.6
Time employed in main current job	1.0	1.2	3.2	-1.8	-0.1	-1.6	-1.2	0.1	-0.1
Illnesses of father: Heart disease	1.0	1.4	2.0	-1.0	-0.7	-1.4	-1.3	-1.3	1.1
Loneliness, isolation	1.0	1.4	4.4	-2.1	0.7	-1.4	-1.2	0.3	0.0
Illnesses of father: None of the above (group 1)	1.0	1.2	3.2	1.0	0.4	1.8	1.2	1.0	-0.7
Medication: Paracetamol	1.0	1.6	2.4	-1.4	-1.5	-1.0	-1.5	-0.8	1.3
Fasting Glucose	0.9	1.1	2.3	1.5	0.5	1.3	1.2	0.8	0.0
Frequency of depressed mood in last 2 weeks	0.9	1.2	2.8	-1.7	-0.1	-1.7	-1.3	-0.3	0.2
Number of incorrect matches in round	0.9	1.5	3.3	-1.8	0.2	-1.5	-0.4	1.6	-1.0
Had other major operations	0.9	1.0	2.0	1.0	-0.3	1.1	-0.1	-1.4	1.4
Medication: Ramipril	0.9	1.2	2.7	0.8	0.7	0.8	1.1	1.6	-1.2
Hair/balding pattern: Pattern 3	0.9	1.4	4.0	1.0	-1.2	0.7	-0.2	-2.0	1.1
Tense / ‘highly strung’	0.9	1.4	2.8	-1.7	-1.0	-1.5	-1.3	-0.4	0.7
High blood pressure (siblings)	0.9	1.3	4.2	1.3	2.0	0.4	0.7	0.1	-1.1
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.2	0.4	1.4	0.8	0.7	1.5	-1.1
Ever had bowel cancer screening	0.9	1.1	2.1	-1.4	1.0	-1.2	-0.5	1.3	0.1
Tinnitus: Yes, now most or all of the time	0.9	1.1	2.7	1.2	0.0	1.6	1.4	-0.1	-0.5
Number of operations (self-reported)	0.9	1.4	2.3	-1.3	-0.7	-1.1	-1.5	-1.0	1.3
Alcohol drinker status: Previous	0.9	1.1	3.6	0.6	1.9	0.8	0.6	0.7	-0.9
Worry (Nagel 2018)	0.8	1.8	3.1	-1.8	-0.3	-1.5	-1.7	-1.1	1.0
Blood White Count	0.8	6.0	12.5	-3.5	-1.2	-3.2	-3.3	-0.2	1.0
BMI	0.8	4.6	10.6	-3.3	-2.0	-2.4	-2.3	-0.1	1.4
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	1.9	0.7	1.1	1.4	1.2	0.6	-0.4
Severe depression (siblings)	0.8	0.9	1.7	-1.3	-0.7	-1.3	-0.9	-0.1	0.9
Hand grip strength (right)	0.8	2.1	4.9	-2.1	-1.5	-2.2	-0.8	0.5	0.5
Medication: Levothyroxine sodium	0.8	1.4	2.6	1.6	1.4	1.5	1.1	-0.7	0.0
Nervous feelings	0.8	1.5	3.1	-0.7	-0.8	-0.8	-1.4	-1.8	1.6
Impedance of arm (right)	0.8	3.8	9.0	-0.9	-2.4	-1.1	-1.4	-3.0	2.0
Impedance of arm (left)	0.8	3.7	8.6	-0.7	-2.5	-1.2	-1.4	-2.9	1.9
Length of working week for main job	0.8	0.9	1.8	0.5	1.3	0.3	0.8	1.3	-0.9
Leg fat percentage (right)	0.8	3.1	9.0	-3.0	-0.1	-2.3	-1.5	1.4	-0.2
Medication: Ibuprofen	0.8	1.0	2.0	-0.4	-1.4	-0.6	-0.6	-1.3	1.2
Alcohol intake frequency.	0.8	1.7	3.9	1.2	1.8	2.0	1.0	0.7	-0.7
Illness, injury, bereavement, stress in last 2 years	0.8	0.9	1.4	1.1	0.4	0.8	1.1	0.9	-1.2
Leg fat percentage (left)	0.8	2.7	7.1	-2.7	0.4	-1.9	-1.0	1.9	-0.9
Average weekly fortified wine intake	0.7	0.8	2.2	0.2	-1.5	-0.2	-0.4	-1.1	1.2
Fed-up feelings	0.7	1.3	3.3	-0.5	1.5	0.1	0.2	1.8	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.7	3.9	-2.0	-0.9	-1.9	-1.1	-0.4	0.6
Supplements: Glucosamine	0.7	0.9	2.1	1.5	-0.2	1.3	0.7	-0.8	0.5
Alcohol intake versus 10 years previously	0.7	1.1	2.8	0.7	1.7	1.3	0.9	0.8	-0.5
Illnesses of mother	0.7	0.9	1.5	-1.0	-0.9	-0.9	-0.9	-0.6	1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.2	4.9	2.2	0.7	2.0	1.6	0.6	-0.7
Medication: Amlodipine	0.7	1.0	2.4	-0.7	0.9	-0.1	0.4	1.5	-1.6
Qualifications: College or University degree	0.7	2.1	4.4	-0.9	-2.1	-0.8	-0.4	-1.5	2.1
Medication: Omeprazole	0.7	0.9	2.1	-0.4	-0.9	0.0	-0.7	-1.3	1.5
Overall health rating	0.7	1.6	4.2	-0.5	2.0	-0.1	0.2	1.4	-1.7
Osteoporosis (self-reported)	0.7	0.9	2.7	0.0	1.1	0.2	0.4	1.7	-1.1
Mother’s age at death	0.7	0.8	1.7	0.4	-1.3	0.3	-0.0	-1.2	1.2
Medication: Lisinopril	0.7	0.8	2.3	-0.9	-1.5	-0.7	-0.6	-0.5	1.0
Major Depression (MDD)	0.6	0.7	2.0	-0.3	1.0	-0.2	0.1	1.4	-1.1
Triglycerides	0.6	0.9	2.3	-1.5	-0.5	-1.4	-0.9	0.4	0.0
Hearing difficulty/problems: Yes	0.6	0.9	1.4	0.2	1.2	0.9	1.1	1.0	-0.8
Townsend deprivation index at recruitment	0.6	0.9	2.4	-1.6	-1.0	-1.2	-0.8	0.3	-0.1
Relative age voice broke	0.6	1.0	2.3	-1.3	1.5	-1.0	-0.6	0.5	-0.5
Taking other prescription medications	0.6	0.9	1.4	-0.9	-0.4	-0.7	-1.0	-1.2	1.2
Chronic bronchitis/emphysema (father)	0.6	0.8	2.1	-1.4	0.2	-1.1	-0.9	0.6	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	3.4	-1.8	-1.0	-1.9	-0.9	-0.0	0.2
Diabetes (self-reported)	0.6	0.9	2.0	0.8	0.1	1.4	1.2	0.8	-0.9
Father’s age at death	0.6	0.9	2.8	0.6	-0.1	-0.1	-0.8	-1.7	1.2
Number of live births	0.6	0.8	1.5	0.6	0.6	0.8	1.1	1.2	-1.0
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.7	-0.1	-1.3	-0.2	-0.3	-1.0	1.2
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	2.1	-0.0	-1.1	-0.2	-0.4	-1.5	1.1
Medication: Lansoprazole	0.6	0.7	2.2	-0.3	0.9	-0.5	-0.0	1.5	-0.7
Number of children fathered	0.6	0.7	2.0	1.1	0.3	1.4	0.8	-0.2	-0.0
Age at first live birth	0.6	1.1	3.7	0.6	-0.9	0.1	-0.0	-1.9	1.3
Medication: Allopurinol	0.6	0.8	1.3	0.6	0.7	1.2	0.9	0.9	-0.7
Had major operations	0.6	0.7	1.6	-1.3	-0.3	-1.1	-1.1	-0.2	0.5
Diabetes diagnosed by doctor	0.6	1.0	2.0	1.1	0.4	1.4	1.2	0.7	-0.6
Wears glasses or contact lenses	0.6	0.7	2.2	-1.5	-0.3	-0.9	-0.8	-0.7	0.5
Hearing aid user	0.6	0.7	1.6	-0.9	1.1	-0.5	-0.3	1.3	-0.5
Alzheimer’s Disease (including proxy)	0.5	0.8	1.9	1.4	0.5	1.2	0.8	-0.6	-0.0
Ovarian Cancer	0.5	0.6	2.3	0.5	-0.0	0.6	0.0	-1.5	0.9
HDL Cholesterol	0.5	0.8	1.4	-1.2	-0.7	-1.1	-1.1	-0.5	0.0
Neuroticism (2016)	0.5	0.7	1.3	-1.1	1.1	-0.7	-0.4	1.1	-0.5
Blood Eosinophil Count	0.5	3.5	7.5	-2.7	-0.1	-2.7	-2.2	1.0	-0.6
Lung FVC	0.5	2.5	5.7	0.9	1.4	0.8	1.3	2.4	-2.0
Neuroticism	0.5	1.2	3.4	-1.8	0.2	-1.4	-1.3	0.0	0.1
Average weekly spirits intake	0.5	0.6	1.4	1.2	1.0	0.4	0.5	0.6	-0.7
Ever used hormone-replacement therapy (HRT)	0.5	0.6	3.0	0.5	1.7	0.3	-0.1	0.3	-0.4
Illnesses of siblings	0.5	0.7	2.1	-0.2	-1.5	0.6	-0.1	-0.5	1.2
Body fat percentage	0.5	1.9	5.8	-2.4	-0.6	-1.7	-1.2	1.0	0.1
Medication: Blood pressure	0.5	0.9	1.9	0.3	-0.8	0.6	0.8	1.2	-1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.7	0.6	1.3	0.6	0.7	0.7	-0.6
Comparative height size at age 10	0.5	2.5	6.0	2.5	-0.1	2.4	1.8	0.1	-0.1
Suffer from ‘nerves’	0.5	0.8	2.0	-1.4	0.4	-0.9	-1.2	0.2	0.5
Illnesses of siblings: Diabetes	0.5	0.6	1.4	-1.0	0.2	-1.2	-1.1	-0.4	0.1
Medication for cholesterol	0.5	0.8	1.2	1.0	-1.1	0.6	0.2	-1.0	1.1
Alcohol drinker status: Never	0.5	0.6	1.4	0.7	-0.4	1.2	0.6	-1.0	0.5
Neuroticism (Nagel 2018)	0.4	1.0	3.1	-1.8	-0.1	-1.2	-1.1	-0.3	0.2
LDL Cholesterol	0.4	0.6	2.0	-0.1	-0.3	0.8	1.0	1.4	0.0
Primary Biliary Cirrhosis	0.4	0.6	1.2	1.1	0.3	0.7	1.0	0.4	-0.7
Smoking Status	0.4	1.0	2.4	-0.4	1.2	-0.0	0.1	1.6	-1.4
Ever had hysterectomy (womb removed)	0.4	0.5	2.3	0.3	1.5	0.3	0.2	0.4	-0.4
Trunk fat percentage	0.4	1.6	4.6	-2.1	-0.8	-1.6	-1.2	0.5	0.4
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	2.8	0.3	1.7	0.1	-0.3	0.2	-0.2
Qualifications: CSEs or equivalent	0.4	0.6	1.6	0.1	0.7	0.1	0.3	1.1	-1.3
Multivitamins +/- minerals	0.4	0.6	1.3	0.7	0.1	1.1	0.9	0.7	-0.4
Financial difficulties in last 2 years	0.4	0.6	1.3	-0.4	-1.1	-0.2	-0.5	-1.0	0.8
Heart attack	0.4	0.5	1.9	1.4	-0.8	0.5	0.4	-0.2	0.2
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	4.2	2.0	0.4	1.5	1.2	0.4	-0.4
Depression (self-reported)	0.4	0.4	1.1	-1.0	0.2	-0.9	-0.7	-0.2	0.4
Birth weight of first child	0.4	0.7	1.6	1.0	1.3	0.1	0.5	0.6	-0.9
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.6	-0.1	1.3	-0.3	-0.2	0.6	-0.9
Loud music exposure frequency	0.4	0.4	0.9	-0.6	-0.6	-0.6	-0.7	-0.4	1.0
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	0.9	-0.1	0.9	-0.7	-0.5	-0.9	0.7
Forced vital capacity (FVC), Best measure	0.4	1.4	2.3	1.4	0.3	1.5	1.5	0.9	-0.9
Shortness of breath walking on level ground	0.4	0.4	1.0	0.1	0.7	0.1	0.3	0.9	-1.0
Mouth/teeth dental problems: Loose teeth	0.4	0.4	1.0	-0.8	-0.2	-0.8	-0.0	1.0	-0.4
Medication for pain relief, constipation, heartburn	0.4	0.8	1.8	0.2	1.0	0.3	0.5	1.2	-1.3
Leg fat mass (right)	0.4	1.6	4.4	-2.1	-0.1	-1.4	-0.8	1.6	-0.3
Leg pain on walking	0.4	0.5	1.2	0.1	0.1	-0.4	-0.9	-0.8	1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	1.0	-0.7	-1.0	-0.1	-0.5	-0.6	0.8
Miserableness	0.4	0.7	1.4	-1.2	0.7	-1.1	-0.3	0.8	-0.8
Ever taken oral contraceptive pill	0.4	0.4	1.4	-0.1	-0.4	0.1	-0.3	-1.2	0.9
Medication: Blood pressure	0.4	0.8	2.5	-1.6	-0.4	-1.3	-0.8	0.2	-0.1
High cholesterol (Self-reported)	0.4	0.7	1.3	-1.1	0.5	-0.6	0.0	1.0	-1.1
Ever smoked	0.4	0.7	1.1	0.9	1.0	1.0	0.8	0.6	-0.7
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.8	1.3	-0.8	0.5	0.5	-0.2	0.1
Leg fat mass (left)	0.4	1.6	3.7	-1.9	0.2	-1.2	-0.5	1.9	-0.6
Bipolar Disorder (2018)	0.3	0.4	1.1	-0.9	0.2	-0.5	-0.1	1.1	-0.4
Depressed Affect (Nagel 2018)	0.3	0.7	1.2	-0.8	0.9	-0.2	0.2	1.1	-1.1
Alzheimer’s Disease (in mother)	0.3	0.4	1.1	0.5	-0.6	0.4	0.1	-1.1	0.5
Alzheimer’s Disease (in father)	0.3	0.3	0.9	0.9	0.5	0.7	0.3	-0.5	0.1
Verbal and Numeric Reasoning (VNR)	0.3	0.6	1.4	-0.6	-1.2	-0.6	-0.3	-0.9	0.8
Waist Hip Ratio (WHR)	0.3	1.5	3.3	1.8	-0.3	1.8	1.3	-0.8	-0.4
Cardiovascular Disease	0.3	0.9	2.8	-1.7	-1.0	-1.0	-0.6	0.6	-0.3
Hair Pigment	0.3	8.0	31.6	5.6	1.7	3.0	1.9	-0.8	0.3
Vitamin and mineral supplements	0.3	0.4	0.9	-0.2	-0.0	-0.8	-0.8	-0.9	0.4
Pack years adult smoking proportion	0.3	0.5	1.1	-1.0	-1.1	-0.7	-0.4	-0.1	-0.1
Sitting height	0.3	2.2	4.2	0.9	-1.8	0.8	0.2	-2.1	2.0
Trunk fat mass	0.3	1.1	3.1	-1.8	-0.9	-1.2	-0.8	0.8	0.3
Neuroticism score	0.3	0.7	1.7	-1.3	0.6	-1.0	-1.0	0.1	0.1
Arm fat percentage (right)	0.3	1.0	2.7	-1.6	-0.4	-1.2	-1.0	0.8	0.1
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.1	0.7	-0.9	0.9	1.0	-0.6	0.2
Asthma	0.3	0.6	1.7	-0.8	-1.3	-0.6	-0.6	-0.3	0.7
Prospective memory result	0.3	0.4	0.8	-0.6	0.9	-0.6	-0.5	0.6	-0.3
Exposure to tobacco smoke at home	0.3	0.3	1.0	0.4	0.1	1.0	0.6	0.3	0.1
Hair/balding pattern: Pattern 4	0.3	0.8	1.4	-1.1	-1.2	-1.1	-0.7	-0.4	0.6
Peak expiratory flow (PEF)	0.3	0.6	1.5	1.2	-0.1	1.1	0.8	-0.2	0.5
Comparative body size at age 10	0.3	0.7	2.4	-0.7	0.2	-0.2	0.7	0.9	-1.5
Medication: Seretide 50 evohaler	0.3	0.3	0.7	-0.8	-0.3	-0.5	-0.7	0.1	0.4
Heart disease (mother)	0.3	0.3	0.9	-0.6	-0.7	-0.9	-0.4	-0.5	-0.1
Whole body fat mass	0.3	1.4	3.9	-2.0	-0.7	-1.4	-1.0	1.0	0.2
Knee pain experienced in last month	0.3	0.5	1.5	0.5	0.3	1.2	0.7	0.6	-0.6
Smoking status: Previous	0.3	0.4	1.2	1.1	0.6	0.8	0.6	0.1	-0.2
Arm fat percentage (left)	0.3	1.2	3.0	-1.7	-0.6	-1.4	-1.1	0.8	0.2
Mood swings	0.3	0.6	1.0	0.6	0.8	0.9	0.8	0.3	-1.0
Medication: Gliclazide	0.3	0.3	0.9	0.4	0.4	0.3	0.4	0.9	-0.6
Smoking status: Current	0.3	0.4	1.2	-1.1	0.3	-0.6	-0.5	0.7	-0.4
Commuting to job workplace: Public transport	0.3	0.4	1.1	-0.3	-0.4	0.0	-0.4	-1.1	0.8
Ever had prostate specific antigen (PSA) test	0.3	0.4	1.0	-1.0	0.2	-0.8	-0.5	0.1	0.4
Fractured/broken bones in last 5 years	0.3	0.4	2.1	-0.3	1.4	0.0	-0.0	0.6	0.0
Ever depressed for a whole week	0.3	0.4	0.8	0.7	0.2	0.9	0.6	0.3	-0.6
Unable to work because of sickness or disability	0.3	0.4	1.0	-0.3	1.0	0.4	0.1	0.8	-0.7
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	0.9	-0.0	-0.6	0.3	-0.4	-0.8	0.9
Impedance of whole body	0.3	1.7	3.6	-1.1	-1.5	-1.1	-0.9	-1.9	1.0
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.5	0.5	-1.1	0.3	0.3	-1.2	0.6
Height	0.2	3.9	6.6	2.6	-1.9	2.5	2.1	-1.5	0.8
Type 2 Diabetes (T2D) (2018)	0.2	0.3	0.6	0.0	-0.8	0.3	-0.1	-0.7	0.8
Hand grip strength (left)	0.2	0.6	1.6	-0.2	-1.3	-0.3	0.9	0.8	-0.4
Sensitivity / hurt feelings	0.2	0.3	0.5	0.7	0.5	0.5	-0.2	-0.7	0.3
Medication: Co-codamol	0.2	0.3	0.4	-0.3	-0.4	-0.2	-0.6	-0.7	0.6
Diabetes (father)	0.2	0.2	0.5	0.4	0.1	0.2	-0.0	-0.7	0.7
Impedance of leg (right)	0.2	1.0	2.4	-1.5	-0.7	-1.3	-0.8	-0.9	0.4
Leg fat-free mass (left)	0.2	0.8	2.6	-0.2	-1.6	-0.3	-0.6	-0.3	1.4
Current tobacco smoking	0.2	0.4	1.2	-1.1	0.2	-0.6	-0.5	0.7	-0.4
Body mass index (BMI)	0.2	1.0	1.9	-1.4	0.2	-1.1	-0.8	1.4	-0.3
Leg predicted mass (left)	0.2	0.9	2.6	-0.3	-1.6	-0.4	-0.6	-0.2	1.4
Hearing difficulty/problems with background noise	0.2	0.3	0.7	-0.8	-0.8	-0.5	-0.3	-0.1	0.3
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	1.1	0.1	1.1	0.2	0.0	-0.0	-0.2
Pain all over the body in last month	0.2	0.3	0.8	-0.3	-0.0	-0.1	0.1	0.9	-0.8
Fluid intelligence score	0.2	0.5	1.4	-1.2	0.2	-1.0	-0.2	0.1	-0.4
Hip circumference	0.2	0.8	1.2	-1.1	-0.8	-1.1	-1.0	0.1	0.8
Standing height	0.2	2.0	5.1	0.9	-2.2	0.8	0.5	-1.7	1.6
Gout (self-reported)	0.2	0.2	0.7	0.5	0.2	0.8	0.5	0.2	0.2
Number of full brothers	0.2	0.2	0.6	0.8	0.6	-0.3	0.1	0.2	-0.6
Migraine (self-reported)	0.2	0.3	0.6	-0.8	-0.6	-0.3	-0.4	-0.4	0.6
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.8	-0.1	-0.6	-0.1	-0.3	-0.6	0.9
Hypertension (Self-reported)	0.2	0.5	1.0	-1.0	-0.8	-0.7	-0.4	0.6	-0.7
Average weekly red wine intake	0.2	0.2	0.4	0.6	0.6	0.2	0.4	-0.4	-0.5
Eye problems/disorders: Cataract	0.2	0.2	0.7	0.0	-0.9	-0.1	0.3	0.6	-0.3
Back pain experienced in last month	0.2	0.3	0.7	-0.9	0.5	-0.6	-0.7	-0.0	0.1
Asthma (self-reported)	0.2	0.4	1.3	-0.7	-1.1	-0.5	-0.4	0.1	0.4
Arm fat mass (left)	0.2	0.7	1.6	-1.2	-0.3	-0.9	-0.6	1.2	-0.2
Number of self-reported non-cancer illnesses	0.2	0.3	1.2	-0.0	1.1	0.5	0.4	0.0	-0.2
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.7	0.1	0.4	0.6	0.0	-0.8	0.6
Illnesses of father: High blood pressure	0.2	0.3	0.6	-0.7	0.5	-0.8	-0.5	-0.3	-0.1
Commuting to job workplace: Cycle	0.2	0.2	0.6	-0.6	0.7	-0.5	-0.2	-0.3	-0.1
Heart disease (siblings)	0.2	0.2	0.7	-0.4	-0.4	-0.8	-0.3	0.3	-0.1
Lupus	0.1	0.2	0.4	-0.2	-0.3	-0.2	-0.7	-0.6	0.4
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.3	-0.4	0.5	0.1	-0.0	0.6	0.0
Respiratory disease	0.1	0.3	0.8	-0.7	-0.9	-0.4	-0.2	0.1	0.2
Chronotype (morning person)	0.1	0.1	0.7	-0.8	-0.4	-0.1	-0.0	0.1	-0.1
Relative age of first facial hair	0.1	0.2	0.6	0.1	0.8	-0.1	-0.1	-0.5	0.3
Angina	0.1	0.1	0.3	0.1	-0.5	0.6	0.4	0.0	-0.1
Medication for hormone replacement therapy	0.1	0.1	0.3	0.2	0.2	0.3	-0.2	-0.4	0.5
Diabetes (mother)	0.1	0.2	0.4	0.5	0.7	0.6	0.1	-0.0	0.1
Maternal smoking around birth	0.1	0.1	0.2	-0.3	-0.2	-0.0	-0.1	0.4	-0.4
High blood pressure	0.1	0.3	0.6	-0.6	-0.5	-0.3	-0.1	0.5	-0.8
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.3	-0.0	0.1	0.6	0.2	0.3	0.4
High blood pressure (mother)	0.1	0.2	0.6	0.8	0.2	0.4	0.2	0.2	-0.5
Impedance of leg (left)	0.1	0.4	1.0	-1.0	0.2	-0.6	0.2	0.2	-0.9
Past tobacco smoking	0.1	0.2	0.5	-0.4	-0.7	-0.4	-0.3	-0.5	0.5
Hair/balding pattern: Pattern 2	0.1	0.1	0.2	-0.3	-0.0	-0.4	-0.2	-0.5	0.5
Forced vital capacity (FVC)	0.1	0.6	1.0	1.0	-0.3	0.7	0.9	0.8	-0.6
Mouth/teeth dental problems	0.1	0.1	0.2	0.4	-0.4	0.3	0.0	-0.1	0.5
Weight	0.1	0.5	0.8	-0.9	-0.8	-0.7	-0.5	0.6	0.5
Trunk fat-free mass	0.1	0.4	0.8	0.9	-0.3	0.7	0.7	0.7	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.5	-0.5	0.3	-0.7	-0.6	-0.1	0.4
Noisy workplace	0.1	0.2	0.5	0.5	0.0	0.2	-0.2	-0.5	0.7
Arm fat mass (right)	0.1	0.5	1.4	-1.0	-0.3	-0.7	-0.4	1.2	-0.2
Trunk predicted mass	0.1	0.4	0.8	0.9	-0.3	0.8	0.7	0.8	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.6	-0.8	0.0	-0.3	-0.2	-0.3	0.2
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.2	-0.0	-0.5	0.4	0.2	-0.3	0.5
Headache pain in last month	0.1	0.3	0.6	0.5	0.5	0.8	0.6	0.0	-0.1
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.4	0.1	0.3	-0.1	0.2	0.4	-0.7
Arm fat-free mass (right)	0.1	0.3	1.8	0.0	-0.1	0.2	0.4	1.3	-0.1
Exposure to tobacco smoke outside home	0.1	0.1	0.3	0.2	0.3	-0.0	-0.4	0.0	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.6	-0.4	0.7	-0.4	-0.2	0.2	-0.2
Health satisfaction	0.1	0.2	0.7	-0.2	0.8	-0.1	-0.3	-0.2	0.5
Eye problems/disorders: None of the above	0.1	0.1	0.2	-0.1	-0.2	-0.3	-0.5	-0.5	0.4
Emphysema/chronic bronchitis	0.1	0.1	0.4	0.7	0.2	0.4	0.2	-0.4	-0.0
Neck or shoulder pain in last month	0.1	0.1	0.5	-0.3	0.7	-0.0	-0.3	0.3	-0.2
Angina (self-reported)	0.1	0.2	0.6	0.4	-0.3	0.7	0.5	0.0	-0.1
Arm predicted mass (right)	0.1	0.4	2.0	-0.1	-0.3	0.1	0.5	1.4	-0.3
Age at last live birth	0.1	0.2	0.6	0.2	0.2	0.3	0.8	0.3	-0.4
Medication: Aspirin	0.1	0.1	0.3	0.5	0.4	0.1	0.2	-0.2	0.0
Supplements: Vitamin C	0.1	0.1	0.3	-0.5	-0.5	-0.1	0.2	0.5	0.0
Leg fat-free mass (right)	0.1	0.4	1.1	0.5	-1.1	0.5	0.1	0.2	0.7
Long-standing illness, disability or infirmity	0.1	0.1	0.4	-0.5	0.3	-0.2	-0.3	-0.6	-0.0
Qualifications: nursing, teaching	0.1	0.2	0.9	-0.3	-0.9	0.1	0.2	-0.3	0.2
Osteoarthritis (self-reported)	0.1	0.2	0.7	0.2	0.3	0.8	0.4	-0.2	-0.2
Medication: Aspirin	0.1	0.1	0.3	0.2	0.6	-0.2	0.0	-0.1	-0.2
Leg predicted mass (right)	0.1	0.4	1.3	0.5	-1.1	0.4	0.1	0.2	0.7
Arm fat-free mass (left)	0.1	0.4	2.1	-0.1	0.1	0.2	0.5	1.4	-0.3
Average weekly beer plus cider intake	0.1	0.2	0.5	-0.2	-0.5	-0.3	0.1	0.7	-0.5
Irritability	0.1	0.1	0.5	-0.7	0.1	-0.3	-0.2	0.5	0.1
Age started oral contraceptive pill	0.1	0.1	0.4	-0.5	0.6	-0.0	0.1	-0.3	-0.3
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.5	0.7	0.3	0.3	0.2	-0.5	0.7
Pain experienced in last month	0.1	0.2	0.5	-0.0	-0.7	-0.2	-0.2	-0.4	0.5
Supplements: Calcium	0.1	0.1	0.3	-0.2	0.2	-0.1	0.2	0.6	-0.2
Basal cell carcinoma (self-reported)	0.1	0.1	0.4	0.6	-0.2	0.5	0.4	-0.1	-0.2
Pack years of smoking	0.1	0.2	0.3	-0.5	-0.5	-0.3	0.0	0.3	-0.5
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Tanning	0.0	0.5	1.0	0.6	-1.0	0.9	0.2	-0.4	0.8
Number of treatments/medications taken	0.0	0.0	0.2	-0.4	0.0	-0.1	-0.2	-0.0	0.1
Waist circumference	0.0	0.2	0.7	-0.1	0.0	0.2	0.2	0.9	-0.5
Birth weight	0.0	0.0	0.1	-0.2	-0.1	-0.1	-0.0	0.3	-0.3
Number of full sisters	0.0	0.0	0.1	-0.0	-0.3	-0.1	0.0	-0.0	-0.2
Whole body fat-free mass	0.0	0.2	0.5	0.5	-0.7	0.4	0.3	0.5	0.4
Commuting to job workplace: Walk	0.0	0.0	0.1	0.3	-0.0	0.2	0.0	-0.2	0.2
Whole body water mass	0.0	0.2	0.5	0.4	-0.7	0.3	0.3	0.6	0.4
Medication: Bendroflumethiazide	0.0	0.1	0.3	-0.3	-0.5	0.0	0.1	-0.1	-0.2
Basal metabolic rate	0.0	0.2	0.6	0.2	-0.7	0.2	0.2	0.8	0.3
Myopia	0.0	0.1	0.1	0.0	0.1	0.2	0.3	0.3	-0.2
Arm predicted mass (left)	0.0	0.2	1.3	-0.1	-0.2	0.1	0.3	1.1	-0.1

Hub : Genes

MOSPD3

Models

Trait associations